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    Alexandra Newton

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPharmacology
    Address9500 Gilman Drive #0721
    CA La Jolla 92093
    Phone858-534-4527
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Ph.D.Stanford University

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Molecular Mechanisms of Cell Signaling
      NIH/NIGMS R35GM122523Jun 1, 2017 - May 31, 2022
      Role: Principal Investigator
      Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
      NIH/NIGMS R01GM067946May 1, 2003 - Jul 31, 2015
      Role: Principal Investigator
      PROTEIN KINASE C: STRUCTURE/REGULATION/CELLULAR FUNCTION
      NIH/NCI R13CA085161Feb 7, 2000 - Feb 6, 2001
      Role: Principal Investigator
      PKA & PKC Targeting Mechanisms (Program Project)
      NIH/NIDDK P01DK054441Dec 15, 1998 - Mar 31, 2018
      Role: Co-Investigator
      ON SIGNAL TRANSDUCTION AND LIPID SECOND MESSENGERS
      NIH/NIGMS R13GM057207Mar 1, 1998 - Feb 28, 1999
      Role: Principal Investigator
      PROTEIN KINASE C AND PHOTORECEPTORS
      NIH/NEI R01EY008820Aug 1, 1991 - Feb 28, 2004
      Role: Principal Investigator
      Structure, Function and Regulation of Protein Kinase C
      NIH/NIGMS R01GM043154Dec 1, 1989 - May 31, 2017
      Role: Principal Investigator
      Structure, Function and Regulation of Protein Kinase C
      NIH/NIGMS R37GM043154Dec 1, 1989 - Aug 31, 2013
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator
      EFFECT OF ACTIVATION ON MEMBRANE-BOUND PROTEIN KINASE C
      NIH/NIGMS F32GM011356Feb 14, 1987
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites
      Collapse In The News

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Newton A. Protein kinase C as a tumor suppressor. Semin Cancer Biol. 2017 May 02. PMID: 28476658.
        View in: PubMed
      2. Newton A, Brognard J. Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor. Trends Pharmacol Sci. 2017 May; 38(5):438-447. PMID: 28283201.
        View in: PubMed
      3. Newton A, Antal CE, Steinberg SF. Protein kinase C mechanisms that contribute to cardiac remodelling. Clin Sci (Lond). 2016 Sep 01; 130(17):1499-510. PMID: 27433023; PMCID: PMC5024564.
      4. Newton A, Bootman MD, Scott JD. Second Messengers. Cold Spring Harb Perspect Biol. 2016 Aug 01; 8(8). PMID: 27481708.
        View in: PubMed
      5. Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton A, Tanzi RE, Malinow R. Gain-of-function mutations in protein kinase Ca (PKCa) may promote synaptic defects in Alzheimer's disease. Sci Signal. 2016 May 10; 9(427):ra47. PMID: 27165780.
        View in: PubMed
      6. Newton A, Tanzi RE, VanHook AM. Science Signaling Podcast for 10 May 2016: PKCa in Alzheimer's disease. Sci Signal. 2016 May 10; 9(427):pc11. PMID: 27165779.
        View in: PubMed
      7. Tobias IS, Newton A. Protein Scaffolds Control Localized Protein Kinase C? Activity. J Biol Chem. 2016 Jun 24; 291(26):13809-22. PMID: 27143478; PMCID: PMC4919463 [Available on 06/24/17].
      8. Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King CC, Newton A. Protein kinase C? exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. Biochem J. 2016 Feb 15; 473(4):509-23. PMID: 26635352; PMCID: PMC4888060.
      9. Antal CE, Callender JA, Kornev AP, Taylor SS, Newton A. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C ßII. Cell Rep. 2015 Aug 25; 12(8):1252-60. PMID: 26279568; PMCID: PMC4551583.
      10. Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton A. Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. J Biol Chem. 2015 Sep 04; 290(36):21845-56. PMID: 26187466; PMCID: PMC4571940.
      11. Bradley EW, Carpio LR, Newton A, Westendorf JJ. Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation. J Biol Chem. 2015 Jun 26; 290(26):16272-80. PMID: 25953896; PMCID: PMC4481226.
      12. Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton A. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell. 2015 Jan 29; 160(3):489-502. PMID: 25619690; PMCID: PMC4313737.
      13. Kunkel MT, Newton A. Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation. Chem Biol. 2015 Jan 22; 22(1):98-106. PMID: 25556943; PMCID: PMC4311772.
      14. Antal CE, Newton A. Tuning the signalling output of protein kinase C. Biochem Soc Trans. 2014 Dec; 42(6):1477-83. PMID: 25399557.
        View in: PubMed
      15. Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton A. Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):E3957-65. PMID: 25201979; PMCID: PMC4183331.
      16. Sierecki E, Newton A. Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase. Biochemistry. 2014 Jun 24; 53(24):3971-81. PMID: 24892992; PMCID: PMC4072346.
      17. Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton A, Sun P, Zhou H, Fu XD. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014 May 08; 54(3):378-91. PMID: 24703948; PMCID: PMC4019712.
      18. Cone AC, Cavin G, Ambrosi C, Hakozaki H, Wu-Zhang AX, Kunkel MT, Newton A, Sosinsky GE. Protein kinase Cd-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. J Biol Chem. 2014 Mar 28; 289(13):8781-98. PMID: 24500718; PMCID: PMC3979370.
      19. Kunkel MT, Newton A. Imaging kinase activity at protein scaffolds. Methods Mol Biol. 2014; 1071:129-37. PMID: 24052385; PMCID: PMC4043534.
      20. Newton A, Trotman LC. Turning off AKT: PHLPP as a drug target. Annu Rev Pharmacol Toxicol. 2014; 54:537-58. PMID: 24392697; PMCID: PMC4082184.
      21. Antal CE, Newton A. Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Mol Cell Proteomics. 2013 Dec; 12(12):3498-508. PMID: 23788531; PMCID: PMC3861703.
      22. Wu-Zhang AX, Newton A. Protein kinase C pharmacology: refining the toolbox. Biochem J. 2013 Jun 01; 452(2):195-209. PMID: 23662807; PMCID: PMC4079666.
      23. Scott AM, Antal CE, Newton A. Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Ca. J Biol Chem. 2013 Jun 07; 288(23):16905-15. PMID: 23589289; PMCID: PMC3675623.
      24. Wu-Zhang AX, Murphy AN, Bachman M, Newton A. Isozyme-specific interaction of protein kinase Cd with mitochondria dissected using live cell fluorescence imaging. J Biol Chem. 2012 Nov 02; 287(45):37891-906. PMID: 22988234; PMCID: PMC3488061.
      25. de Lichtervelde L, Antal CE, Boitano AE, Wang Y, Krastel P, Petersen F, Newton A, Cooke MP, Schultz PG. Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation. Chem Biol. 2012 Aug 24; 19(8):994-1000. PMID: 22921066; PMCID: PMC4079670.
      26. Scott JD, Newton A. Shedding light on local kinase activation. BMC Biol. 2012 Jul 17; 10:61. PMID: 22805055; PMCID: PMC3398854.
      27. O'Neill AK, Niederst MJ, Newton A. Suppression of survival signalling pathways by the phosphatase PHLPP. FEBS J. 2013 Jan; 280(2):572-83. PMID: 22340730; PMCID: PMC3770140.
      28. Wu-Zhang AX, Schramm CL, Nabavi S, Malinow R, Newton A. Cellular pharmacology of protein kinase M? (PKM?) contrasts with its in vitro profile: implications for PKM? as a mediator of memory. J Biol Chem. 2012 Apr 13; 287(16):12879-85. PMID: 22378786; PMCID: PMC3339930.
      29. Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor SS, Jennings PA, Newton A. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. J Biol Chem. 2012 Apr 13; 287(16):13262-78. PMID: 22318721; PMCID: PMC3339987.
      30. Warfel NA, Newton A. Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling. J Biol Chem. 2012 Feb 03; 287(6):3610-6. PMID: 22144674; PMCID: PMC3281723.
      31. O'Neill AK, Gallegos LL, Justilien V, Garcia EL, Leitges M, Fields AP, Hall RA, Newton A. Protein kinase Ca promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). J Biol Chem. 2011 Dec 16; 286(50):43559-68. PMID: 22027822; PMCID: PMC3234831.
      32. Warfel NA, Niederst M, Newton A. Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2. J Biol Chem. 2011 Nov 11; 286(45):39122-9. PMID: 21908613; PMCID: PMC3234737.
      33. Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Navin N, Atwal GS, Sander C, Gerald WL, Cordon-Cardo C, Newton A, Carver BS, Trotman LC. Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell. 2011 Aug 16; 20(2):173-86. PMID: 21840483; PMCID: PMC3176728.
      34. Bossuyt J, Chang CW, Helmstadter K, Kunkel MT, Newton A, Campbell KS, Martin JL, Bossuyt S, Robia SL, Bers DM. Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin. J Biol Chem. 2011 Sep 23; 286(38):33390-400. PMID: 21795686; PMCID: PMC3190922.
      35. Gould CM, Antal CE, Reyes G, Kunkel MT, Adams RA, Ziyar A, Riveros T, Newton A. Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form. J Biol Chem. 2011 Aug 19; 286(33):28922-30. PMID: 21715334; PMCID: PMC3190699.
      36. Keshwani MM, von Daake S, Newton A, Harris TK, Taylor SS. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). J Biol Chem. 2011 Jul 01; 286(26):23552-8. PMID: 21561857; PMCID: PMC3123118.
      37. Patterson SJ, Han JM, Garcia R, Assi K, Gao T, O'Neill A, Newton A, Levings MK. Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. J Immunol. 2011 May 15; 186(10):5533-7. PMID: 21498666; PMCID: PMC4015973.
      38. Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC, Newton A. Mislocalization of the E3 ligase, ß-transducin repeat-containing protein 1 (ß-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt. J Biol Chem. 2011 Jun 03; 286(22):19777-88. PMID: 21454620; PMCID: PMC3103356.
      39. Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton A, Hua XY, Yaksh TL. Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. J Neurosci. 2011 Feb 09; 31(6):2113-24. PMID: 21307248; PMCID: PMC3097059.
      40. Gallegos LL, Newton A. Genetically encoded fluorescent reporters to visualize protein kinase C activation in live cells. Methods Mol Biol. 2011; 756:295-310. PMID: 21870234; PMCID: PMC4048020.
      41. Kajimoto T, Sawamura S, Tohyama Y, Mori Y, Newton A. Protein kinase C {delta}-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases. J Biol Chem. 2010 Dec 31; 285(53):41896-910. PMID: 20959447; PMCID: PMC3009917.
      42. Sierecki E, Sinko W, McCammon JA, Newton A. Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening. J Med Chem. 2010 Oct 14; 53(19):6899-911. PMID: 20836557; PMCID: PMC2951065.
      43. Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton A, Brown JH. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res. 2010 Aug 20; 107(4):476-84. PMID: 20576936; PMCID: PMC2957297.
      44. Kunkel MT, Newton A. Calcium transduces plasma membrane receptor signals to produce diacylglycerol at Golgi membranes. J Biol Chem. 2010 Jul 23; 285(30):22748-52. PMID: 20519514; PMCID: PMC2906264.
      45. Hoshi N, Langeberg LK, Gould CM, Newton A, Scott JD. Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell. 2010 Feb 26; 37(4):541-50. PMID: 20188672; PMCID: PMC3014287.
      46. Masubuchi S, Gao T, O'Neill A, Eckel-Mahan K, Newton A, Sassone-Corsi P. Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1642-7. PMID: 20080691; PMCID: PMC2824391.
      47. Kunkel MT, Newton A. Spatiotemporal Dynamics of Kinase Signaling Visualized by Targeted Reporters. Curr Protoc Chem Biol. 2009 Dec 01; 1(1):17-18. PMID: 21804950.
        View in: PubMed
      48. Newton A. Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E395-402. PMID: 19934406; PMCID: PMC2838521.
      49. Kunkel MT, Garcia EL, Kajimoto T, Hall RA, Newton A. The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity. J Biol Chem. 2009 Sep 04; 284(36):24653-61. PMID: 19581308; PMCID: PMC2782054.
      50. Brognard J, Niederst M, Reyes G, Warfel N, Newton A. Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. J Biol Chem. 2009 May 29; 284(22):15215-23. PMID: 19324870; PMCID: PMC2685702.
      51. Gould CM, Kannan N, Taylor SS, Newton A. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem. 2009 Feb 20; 284(8):4921-35. PMID: 19091746; PMCID: PMC2643500.
      52. Gallegos LL, Newton A. Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm. IUBMB Life. 2008 Dec; 60(12):782-9. PMID: 18720411; PMCID: PMC2718795.
      53. Newton A. Lipid activation of protein kinases. J Lipid Res. 2009 Apr; 50 Suppl:S266-71. PMID: 19033211; PMCID: PMC2674703.
      54. Newton A. Protein kinase C. IUBMB Life. 2008 Nov; 60(11):765-8. PMID: 18683875.
        View in: PubMed
      55. Carnegie GK, Soughayer J, Smith FD, Pedroja BS, Zhang F, Diviani D, Bristow MR, Kunkel MT, Newton A, Langeberg LK, Scott JD. AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell. 2008 Oct 24; 32(2):169-79. PMID: 18951085; PMCID: PMC3169907.
      56. Gould CM, Newton A. The life and death of protein kinase C. Curr Drug Targets. 2008 Aug; 9(8):614-25. PMID: 18691009.
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      57. Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton A, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 2008 Jul 23; 27(14):1932-43. PMID: 18566586; PMCID: PMC2486276.
      58. Brognard J, Newton A. PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab. 2008 Aug; 19(6):223-30. PMID: 18511290; PMCID: PMC2963565.
      59. Dries DR, Newton A. Kinetic analysis of the interaction of the C1 domain of protein kinase C with lipid membranes by stopped-flow spectroscopy. J Biol Chem. 2008 Mar 21; 283(12):7885-93. PMID: 18187412.
        View in: PubMed
      60. Gao T, Brognard J, Newton A. The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem. 2008 Mar 07; 283(10):6300-11. PMID: 18162466.
        View in: PubMed
      61. Newton A, Mochly-Rosen D. Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007). IUBMB Life. 2007 Dec; 59(12):741-3. PMID: 18085473.
        View in: PubMed
      62. Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton A. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. J Biol Chem. 2007 Nov 16; 282(46):33776-87. PMID: 17893151.
        View in: PubMed
      63. Brognard J, Sierecki E, Gao T, Newton A. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell. 2007 Mar 23; 25(6):917-31. PMID: 17386267.
        View in: PubMed
      64. Kunkel MT, Toker A, Tsien RY, Newton A. Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. J Biol Chem. 2007 Mar 02; 282(9):6733-42. PMID: 17189263; PMCID: PMC2921767.
      65. Dries DR, Gallegos LL, Newton A. A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production. J Biol Chem. 2007 Jan 12; 282(2):826-30. PMID: 17071619.
        View in: PubMed
      66. Gao T, Newton A. Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70. J Biol Chem. 2006 Oct 27; 281(43):32461-8. PMID: 16954220.
        View in: PubMed
      67. Gallegos LL, Kunkel MT, Newton A. Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling. J Biol Chem. 2006 Oct 13; 281(41):30947-56. PMID: 16901905.
        View in: PubMed
      68. Giorgione JR, Lin JH, McCammon JA, Newton A. Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment. J Biol Chem. 2006 Jan 20; 281(3):1660-9. PMID: 16293612; PMCID: PMC2913972.
      69. Gao T, Furnari F, Newton A. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell. 2005 Apr 01; 18(1):13-24. PMID: 15808505.
        View in: PubMed
      70. Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton A. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem. 2005 Feb 18; 280(7):5581-7. PMID: 15583002; PMCID: PMC2913970.
      71. King CC, Newton A. The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2004 Sep 03; 279(36):37518-27. PMID: 15210700.
        View in: PubMed
      72. Newton A. Diacylglycerol's affair with protein kinase C turns 25. Trends Pharmacol Sci. 2004 Apr; 25(4):175-7. PMID: 15116719.
        View in: PubMed
      73. Violin JD, Newton A. Pathway illuminated: visualizing protein kinase C signaling. IUBMB Life. 2003 Dec; 55(12):653-60. PMID: 14769001.
        View in: PubMed
      74. Chen D, Purohit A, Halilovic E, Doxsey SJ, Newton A. Centrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesis. J Biol Chem. 2004 Feb 06; 279(6):4829-39. PMID: 14594954.
        View in: PubMed
      75. Giorgione J, Hysell M, Harvey DF, Newton A. Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C. Biochemistry. 2003 Sep 30; 42(38):11194-202. PMID: 14503869.
        View in: PubMed
      76. Adams RA, Liu X, Williams DS, Newton A. Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light. Biochem J. 2003 Sep 01; 374(Pt 2):537-43. PMID: 12809555; PMCID: PMC1223618.
      77. Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton A, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T. A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9470-5. PMID: 12881490; PMCID: PMC170942.
      78. Bertolini TM, Giorgione J, Harvey DF, Newton A. Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions. J Org Chem. 2003 Jun 27; 68(13):5028-36. PMID: 12816455.
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      79. Violin JD, Zhang J, Tsien RY, Newton A. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol. 2003 Jun 09; 161(5):899-909. PMID: 12782683; PMCID: PMC2172956.
      80. Newton A. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J. 2003 Mar 01; 370(Pt 2):361-71. PMID: 12495431; PMCID: PMC1223206.
      81. Newton A. The ins and outs of protein kinase C. Methods Mol Biol. 2003; 233:3-7. PMID: 12840493.
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      82. Newton A. Measuring the interaction of protein kinase C with membranes: an introduction. Methods Mol Biol. 2003; 233:89-92. PMID: 12840500.
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      83. Giorgione J, Newton A. Measuring the binding of protein kinase C to sucrose-loaded vesicles. Methods Mol Biol. 2003; 233:105-13. PMID: 12840502.
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      84. Nalefski EA, Newton A. Use of stopped-flow fluorescence spectroscopy to measure rapid membrane binding by protein kinase C. Methods Mol Biol. 2003; 233:115-28. PMID: 12840503.
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      85. Gao T, Newton A. The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C. J Biol Chem. 2002 Aug 30; 277(35):31585-92. PMID: 12080070.
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      86. Zacharias DA, Violin JD, Newton A, Tsien RY. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science. 2002 May 03; 296(5569):913-6. PMID: 11988576.
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      87. Cenni V, Döppler H, Sonnenburg ED, Maraldi N, Newton A, Toker A. Regulation of novel protein kinase C epsilon by phosphorylation. Biochem J. 2002 May 01; 363(Pt 3):537-45. PMID: 11964154; PMCID: PMC1222506.
      88. Newton A. Analyzing protein kinase C activation. Methods Enzymol. 2002; 345:499-506. PMID: 11665632.
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      89. Newton A. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev. 2001 Aug; 101(8):2353-64. PMID: 11749377.
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      90. Newton A, Johnson JE. Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules. Biochim Biophys Acta. 1998 Aug 21; 1376(2):155-72. PMID: 9748550.
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      91. Newton A. Regulation of protein kinase C. Curr Opin Cell Biol. 1997 Apr; 9(2):161-7. PMID: 9069266.
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