Igor Wierzbicki

Title(s)	Postdoctoral Scholar, Pharmacology
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Giant polyketide synthase enzymes in the biosynthesis of giant marine polyether toxins. Science. 2024 08 09; 385(6709):671-678. Fallon TR, Shende VV, Wierzbicki IH, Pendleton AL, Watervoort NF, Auber RP, Gonzalez DJ, Wisecaver JH, Moore BS. PMID: 39116217; PMCID: PMC11416037.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Animals Cells
A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling. J Biol Chem. 2024 Jun; 300(6):107393. Zhuang C, Yang S, Gonzalez CG, Ainsworth RI, Li S, Kobayashi MT, Wierzbicki I, Rossitto LM, Wen Y, Peti W, Stanford SM, Gonzalez DJ, Murali R, Santelli E, Bottini N. PMID: 38777143; PMCID: PMC11237943.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Humans Cells
Giant polyketide synthase enzymes biosynthesize a giant marine polyether biotoxin. bioRxiv. 2024 Jan 31. Fallon TR, Shende VV, Wierzbicki IH, Auber RP, Gonzalez DJ, Wisecaver JH, Moore BS. PMID: 38352448; PMCID: PMC10862718.

View in: PubMed Mentions:
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. Cell Metab. 2023 06 06; 35(6):1009-1021.e9. Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. PMID: 37084733; PMCID: PMC10430883.

View in: PubMed Mentions: 2 Fields:
Cel Cell Biology Met Metabolism
Translation:Humans Animals
Group A Streptococcal S Protein Utilizes Red Blood Cells as Immune Camouflage and Is a Critical Determinant for Immune Evasion. Cell Rep. 2019 12 03; 29(10):2979-2989.e15. Wierzbicki IH, Campeau A, Dehaini D, Holay M, Wei X, Greene T, Ying M, Sands JS, Lamsa A, Zuniga E, Pogliano K, Fang RH, LaRock CN, Zhang L, Gonzalez DJ. PMID: 31801066; PMCID: PMC6951797.

View in: PubMed Mentions: 11 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Structural and functional insights into the role of BamD and BamE within the β-barrel assembly machinery in Neisseria gonorrhoeae. J Biol Chem. 2018 01 26; 293(4):1106-1119. Sikora AE, Wierzbicki IH, Zielke RA, Ryner RF, Korotkov KV, Buchanan SK, Noinaj N. PMID: 29229778; PMCID: PMC5787791.

View in: PubMed Mentions: 22 Fields:
Bio Biochemistry
Translation:Humans Cells
Functional and structural studies on the Neisseria gonorrhoeae GmhA, the first enzyme in the glycero-manno-heptose biosynthesis pathways, demonstrate a critical role in lipooligosaccharide synthesis and gonococcal viability. Microbiologyopen. 2017 04; 6(2). Wierzbicki IH, Zielke RA, Korotkov KV, Sikora AE. PMID: 28063198; PMCID: PMC5387315.

View in: PubMed Mentions: 17 Fields:
Mic Microbiology
Translation:Cells
Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea. Mol Cell Proteomics. 2016 07; 15(7):2338-55. Zielke RA, Wierzbicki IH, Baarda BI, Gafken PR, Soge OO, Holmes KK, Jerse AE, Unemo M, Sikora AE. PMID: 27141096; PMCID: PMC4937508.

View in: PubMed Mentions: 49 Fields:
Bio Biochemistry Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Polymeric Micelles as Carriers for Nerve-Highlighting Fluorescent Probe Delivery. Mol Pharm. 2015 Dec 07; 12(12):4386-94. Hackman KM, Doddapaneni BS, Barth CW, Wierzbicki IH, Alani AW, Gibbs SL. PMID: 26485440; PMCID: PMC4674818.

View in: PubMed Mentions: 14 Fields:
Mol Molecular Biology Pha Pharmacology
Translation:Humans Animals Cells
The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target. BMC Microbiol. 2015 Jun 30; 15:129. Zielke RA, Wierzbicki IH, Baarda BI, Sikora AE. PMID: 26122105; PMCID: PMC4487204.

View in: PubMed Mentions: 12 Fields:
Mic Microbiology
Translation:Humans Cells
A metalloprotease secreted by the type II secretion system links Vibrio cholerae with collagen. J Bacteriol. 2015 Mar; 197(6):1051-64. Park BR, Zielke RA, Wierzbicki IH, Mitchell KC, Withey JH, Sikora AE. PMID: 25561716; PMCID: PMC4336349.

View in: PubMed Mentions: 14 Fields:
Bac Bacteriology
Translation:Cells
In situ gelling polyvalerolactone-based thermosensitive hydrogel for sustained drug delivery. Eur J Pharm Biopharm. 2014 Oct; 88(2):397-405. Mishra GP, Kinser R, Wierzbicki IH, Alany RG, Alani AW. PMID: 24931340.

View in: PubMed Mentions: 9 Fields:
Pha Pharmacology
Translation:Animals Cells
Quantitative proteomics of the Neisseria gonorrhoeae cell envelope and membrane vesicles for the discovery of potential therapeutic targets. Mol Cell Proteomics. 2014 May; 13(5):1299-317. Zielke RA, Wierzbicki IH, Weber JV, Gafken PR, Sikora AE. PMID: 24607996; PMCID: PMC4014286.

View in: PubMed Mentions: 50 Fields:
Bio Biochemistry Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells