Nikunj Shukla

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Title(s)	Project Scientist, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
vCard	Download vCard

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Design and Application of Conjugatable Small Molecule Toll-Like Receptor 4 Ligands. Bioconjug Chem. 2025 Jul 16; 36(7):1409-1420. Mahara Y, Fukuda I, Tanaka R, Oyama SY, Shinchi H, Suda Y, Shukla NM, Chan M, Hayashi T, Cottam HB, Carson DA, Wakao M. PMID: 40533421.

View in: PubMed Mentions: Fields:
Bio Biochemistry
Translation:Humans Animals
Structure-Activity Relationship Studies in Benzothiadiazoles as Novel Vaccine Adjuvants. J Med Chem. 2024 08 22; 67(16):13703-13722. Belsuzarri MM, Sako Y, Brown TD, Chan M, Cozza R, Jin J, Sato-Kaneko F, Yao S, Pu M, Messer K, Hayashi T, Cottam HB, Corr M, Carson DA, Shukla NM. PMID: 39115891.

View in: PubMed Mentions: Fields:
Che Chemistry
Translation:Humans Animals Cells
Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx. ACS Chem Biol. 2023 04 21; 18(4):982-993. Sako Y, Sato-Kaneko F, Shukla NM, Yao S, Belsuzarri MM, Chan M, Saito T, Lao FS, Kong H, Puffer M, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T. PMID: 37039433; PMCID: PMC10127211.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Bio Biology
Translation:Animals Cells PHPublic Health
A Dual Adjuvant System for Intranasal Boosting of Local and Systemic Immunity for Influenza Vaccination. Vaccines (Basel). 2022 Oct 11; 10(10). Sato-Kaneko F, Yao S, Lao FS, Sako Y, Jin J, Shukla NM, Cottam HB, Chan M, Belsuzarri MM, Carson DA, Hayashi T. PMID: 36298559; PMCID: PMC9611830.

View in: PubMed Mentions: 2
A Triple High Throughput Screening for Extracellular Vesicle Inducing Agents With Immunostimulatory Activity. Front Pharmacol. 2022; 13:869649. Shukla NM, Sato-Kaneko F, Yao S, Pu M, Chan M, Lao FS, Sako Y, Saito T, Messer K, Hayashi T, Cottam HB, Corr M, Carson DA. PMID: 35479316; PMCID: PMC9035538.

View in: PubMed Mentions: 3
Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity. ACS Chem Biol. 2022 01 21; 17(1):217-229. Saito T, Shukla NM, Sato-Kaneko F, Sako Y, Hosoya T, Yao S, Lao FS, Messer K, Pu M, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. PMID: 34985883; PMCID: PMC8788586.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Bio Biology
Translation:Humans Animals Cells
Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge. Front Immunol. 2021; 12:701445. Saito T, Sako Y, Sato-Kaneko F, Hosoya T, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. PMID: 34650551; PMCID: PMC8505803.

View in: PubMed Mentions: 2 Fields:
All Allergy and Immunology
Translation:Animals Cells
Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Sato-Kaneko F, Yao S, Lao FS, Nan J, Shpigelman J, Cheng A, Saito T, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Molina AJ, Corr M, Hayashi T, Carson DA. PMID: 34078669; PMCID: PMC8201894.

View in: PubMed Mentions: 6 Fields:
Sci Science
Translation:Humans Animals Cells
Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-κB activation. Bioorg Med Chem. 2021 08 01; 43:116242. Shukla NM, Chan M, Lao FS, Chu PJ, Belsuzarri M, Yao S, Nan J, Sato-Kaneko F, Saito T, Hayashi T, Corr M, Carson DA, Cottam HB. PMID: 34274759; PMCID: PMC8992012.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Animals Cells
Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release. Front Pharmacol. 2021; 12:668609. Shpigelman J, Lao FS, Yao S, Li C, Saito T, Sato-Kaneko F, Nolan JP, Shukla NM, Pu M, Messer K, Cottam HB, Carson DA, Corr M, Hayashi T. PMID: 33935791; PMCID: PMC8085554.

View in: PubMed Mentions: 15
Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Front Pharmacol. 2020; 11:607713. Hosoya T, Shukla NM, Fujita Y, Yao S, Lao FS, Baba H, Yasuda S, Cottam HB, Carson DA, Hayashi T, Corr M. PMID: 33390996; PMCID: PMC7773657.

View in: PubMed Mentions: 1
A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity. Front Immunol. 2020; 11:1207. Sato-Kaneko F, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Chu PJ, Burkhart D, Schoener R, Matsutani T, Carson DA, Corr M, Hayashi T. PMID: 32636840; PMCID: PMC7318308.

View in: PubMed Mentions: 14 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli. J Med Chem. 2019 11 14; 62(21):9521-9540. Chan M, Lao FS, Chu PJ, Shpigelman J, Yao S, Nan J, Sato-Kaneko F, Li V, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM. PMID: 31603681; PMCID: PMC8992017.

View in: PubMed Mentions: 4 Fields:
Che Chemistry
Translation:Humans Cells
Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands. Cell Rep. 2018 12 18; 25(12):3371-3381.e5. Zhang Z, Ohto U, Shibata T, Taoka M, Yamauchi Y, Sato R, Shukla NM, David SA, Isobe T, Miyake K, Shimizu T. PMID: 30566863.

View in: PubMed Mentions: 85 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Recent Advances and Perspectives in Small-molecule TLR Ligands and Their Modulators. ACS Med Chem Lett. 2018 Dec 13; 9(12):1156-1159. Shukla NM, Chan M, Hayashi T, Carson DA, Cottam HB. PMID: 30613317; PMCID: PMC6295859.

View in: PubMed Mentions: 7
Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy. Biomed Res Int. 2018; 2018:8091283. Sato-Kaneko F, Wang X, Yao S, Hosoya T, Lao FS, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Carson DA, Corr M, Hayashi T. PMID: 30406141; PMCID: PMC6199861.

View in: PubMed Mentions: 4 Fields:
Bio Biotechnology Med Medicine (General)
Translation:Humans Animals Cells
Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue. Bioconjug Chem. 2018 08 15; 29(8):2741-2754. Yoo E, Salyer ACD, Brush MJH, Li Y, Trautman KL, Shukla NM, De Beuckelaer A, Lienenklaus S, Deswarte K, Lambrecht BN, De Geest BG, David SA. PMID: 29969553.

View in: PubMed Mentions: 16 Fields:
Bio Biochemistry
Translation:Humans Animals
Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants. SLAS Discov. 2018 10; 23(9):960-973. Shukla NM, Arimoto KI, Yao S, Fan JB, Zhang Y, Sato-Kaneko F, Lao FS, Hosoya T, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T, Zhang DE, Corr M. PMID: 29751735; PMCID: PMC6697428.

View in: PubMed Mentions: 7 Fields:
Mol Molecular Biology
Translation:Humans Animals Cells
Structure-Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands. J Med Chem. 2017 11 22; 60(22):9142-9161. Chan M, Kakitsubata Y, Hayashi T, Ahmadi A, Yao S, Shukla NM, Oyama SY, Baba A, Nguyen B, Corr M, Suda Y, Carson DA, Cottam HB, Wakao M. PMID: 29049886; PMCID: PMC5940354.

View in: PubMed Mentions: 11 Fields:
Che Chemistry
Translation:Humans Animals
Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-κB Activation without Intrinsic Activity. ACS Comb Sci. 2017 08 14; 19(8):533-543. Chan M, Ahmadi A, Yao S, Sato-Kaneko F, Messer K, Pu M, Nguyen B, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM. PMID: 28657707; PMCID: PMC5841913.

View in: PubMed Mentions: 13 Fields:
Che Chemistry
Translation:Humans Animals Cells PHPublic Health
pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):8098-103. Nuhn L, Vanparijs N, De Beuckelaer A, Lybaert L, Verstraete G, Deswarte K, Lienenklaus S, Shukla NM, Salyer AC, Lambrecht BN, Grooten J, David SA, De Koker S, De Geest BG. PMID: 27382168; PMCID: PMC4961133.

View in: PubMed Mentions: 76 Fields:
Sci Science
Translation:Animals Cells PHPublic Health
The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes. PLoS One. 2015; 10(8):e0134640. Ganapathi L, Van Haren S, Dowling DJ, Bergelson I, Shukla NM, Malladi SS, Balakrishna R, Tanji H, Ohto U, Shimizu T, David SA, Levy O. PMID: 26274907; PMCID: PMC4537157.

View in: PubMed Mentions: 30 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Design and development of stable, water-soluble, human Toll-like receptor 2 specific monoacyl lipopeptides as candidate vaccine adjuvants. J Med Chem. 2013 Jul 25; 56(14):5885-900. Salunke DB, Connelly SW, Shukla NM, Hermanson AR, Fox LM, David SA. PMID: 23795818; PMCID: PMC3844559.

View in: PubMed Mentions: 19 Fields:
Che Chemistry
Translation:Humans Animals
Structure-activity relationships in human Toll-like receptor 8-active 2,3-diamino-furo[2,3-c]pyridines. J Med Chem. 2012 Sep 27; 55(18):8137-51. Salunke DB, Yoo E, Shukla NM, Balakrishna R, Malladi SS, Serafin KJ, Day VW, Wang X, David SA. PMID: 22924757; PMCID: PMC3461104.

View in: PubMed Mentions: 23 Fields:
Che Chemistry
Translation:Humans Animals Cells
Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer. PLoS One. 2012; 7(8):e43612. Shukla NM, Salunke DB, Balakrishna R, Mutz CA, Malladi SS, David SA. PMID: 22952720; PMCID: PMC3429503.

View in: PubMed Mentions: 45 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Antibacterial activities of Groebke-Blackburn-Bienaymé-derived imidazo[1,2-a]pyridin-3-amines. Bioorg Med Chem. 2012 Oct 01; 20(19):5850-63. Shukla NM, Salunke DB, Yoo E, Mutz CA, Balakrishna R, David SA. PMID: 22925449; PMCID: PMC3448811.

View in: PubMed Mentions: 24 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Structure-activity relationships in human Toll-like receptor 2-specific monoacyl lipopeptides. J Med Chem. 2012 Apr 12; 55(7):3353-63. Salunke DB, Shukla NM, Yoo E, Crall BM, Balakrishna R, Malladi SS, David SA. PMID: 22385476; PMCID: PMC3325328.

View in: PubMed Mentions: 25 Fields:
Che Chemistry
Translation:Humans Animals Cells
Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines. J Med Chem. 2012 Feb 09; 55(3):1106-16. Shukla NM, Mutz CA, Malladi SS, Warshakoon HJ, Balakrishna R, David SA. PMID: 22239408; PMCID: PMC3276691.

View in: PubMed Mentions: 27 Fields:
Che Chemistry
Translation:Humans Cells
Preliminary evaluation of a 3H imidazoquinoline library as dual TLR7/TLR8 antagonists. Bioorg Med Chem. 2011 Jun 15; 19(12):3801-11. Shukla NM, Malladi SS, Day V, David SA. PMID: 21620714; PMCID: PMC3114175.

View in: PubMed Mentions: 17 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Toward self-adjuvanting subunit vaccines: model peptide and protein antigens incorporating covalently bound toll-like receptor-7 agonistic imidazoquinolines. Bioorg Med Chem Lett. 2011 Jun 01; 21(11):3232-6. Shukla NM, Lewis TC, Day TP, Mutz CA, Ukani R, Hamilton CD, Balakrishna R, David SA. PMID: 21549593; PMCID: PMC3098923.

View in: PubMed Mentions: 27 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Animals Cells
Imbuing aqueous solubility to amphotericin B and nystatin with a vitamin. Mol Pharm. 2011 Feb 07; 8(1):297-301. Day TP, Sil D, Shukla NM, Anbanandam A, Day VW, David SA. PMID: 21141891; PMCID: PMC3034802.

View in: PubMed Mentions: 3 Fields:
Mol Molecular Biology Pha Pharmacology
Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorg Med Chem Lett. 2010 Nov 15; 20(22):6384-6. Shukla NM, Mutz CA, Ukani R, Warshakoon HJ, Moore DS, David SA. PMID: 20933417; PMCID: PMC2957514.

View in: PubMed Mentions: 24 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Animals Cells
Structure-activity relationships in human toll-like receptor 7-active imidazoquinoline analogues. J Med Chem. 2010 Jun 10; 53(11):4450-65. Shukla NM, Malladi SS, Mutz CA, Balakrishna R, David SA. PMID: 20481492; PMCID: PMC2895411.

View in: PubMed Mentions: 67 Fields:
Che Chemistry
Translation:Humans
Immunoprofiling toll-like receptor ligands: Comparison of immunostimulatory and proinflammatory profiles in ex vivo human blood models. Hum Vaccin. 2010 Apr; 6(4):322-35. Hood JD, Warshakoon HJ, Kimbrell MR, Shukla NM, Malladi SS, Wang X, David SA. PMID: 20372068.

View in: PubMed Mentions: 30 Fields:
All Allergy and Immunology
Translation:Humans Cells
Potential adjuvantic properties of innate immune stimuli. Hum Vaccin. 2009 Jun; 5(6):381-94. Warshakoon HJ, Hood JD, Kimbrell MR, Malladi S, Wu WY, Shukla NM, Agnihotri G, Sil D, David SA. PMID: 19270494.

View in: PubMed Mentions: 41 Fields:
All Allergy and Immunology
Translation:Humans
Regioisomerism-dependent TLR7 agonism and antagonism in an imidazoquinoline. Bioorg Med Chem Lett. 2009 Apr 15; 19(8):2211-4. Shukla NM, Kimbrell MR, Malladi SS, David SA. PMID: 19285861.

View in: PubMed Mentions: 25 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells