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Biomimetic and personalized nanovaccines in cancer immunotherapy: Design innovations, translational challenges, and future directions. J Adv Res. 2026 Feb 02.
Xu S, Yang H, Minev B, Ma W. PMID: 41638631.
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PubMed Mentions: Fields:
-
Reduction of solid tumors by senescent cell immunization. J Transl Med. 2025 Nov 28; 23(1):1365.
Ichim TE, Lopes G, Reznik R, Bykoriz V, Fortunati CA, Pascual KA, Minev B, Ramos RA, Bajnath A, Lin E, Hu J, Marincola FM, Rath A, Reznik BN. PMID: 41316207; PMCID: PMC12661736.
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PubMed Mentions:
1 Fields:
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Neoadjuvant clinical trials in adults with newly diagnosed high-grade glioma: A systematic review. Crit Rev Oncol Hematol. 2025 Feb; 206:104596.
Juarez TM, Gill JM, Minev BR, Sharma A, Kesari S. PMID: 39675399.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Development of Allogeneic Stem Cell-Based Platform for Delivery and Potentiation of Oncolytic Virotherapy. Cancers (Basel). 2022 Dec 13; 14(24).
Nguyen DH, Herrmann T, Härtl B, Draganov D, Minev I, Neuharth F, Gomez A, Alamillo A, Schneider LE, Kleinholz D, Minev B, Santidrian AF. PMID: 36551636; PMCID: PMC9777144.
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PubMed Mentions:
3
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Correction to: Delivery of oncolytic vaccinia virus by matched allogeneic stem cells overcomes critical innate and adaptive immune barriers. J Transl Med. 2021 Oct 04; 19(1):414.
Draganov DD, Santidrian AF, Minev I, Nguyen D, Kilinc MO, Petrov I, Vyalkova A, Lander E, Berman M, Minev B, Szalay AA. PMID: 34607595; PMCID: PMC8489066.
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PubMed Mentions: Fields:
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Novel Survivin Peptides Screened With Computer Algorithm Induce Cytotoxic T Lymphocytes With Higher Cytotoxic Efficiency to Cancer Cells. Front Mol Biosci. 2020; 7:570003.
Chen Q, Jia G, Zhao X, Bao Y, Zhang Y, Ozkan C, Minev B, Ma W. PMID: 33102521; PMCID: PMC7496070.
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PubMed Mentions:
5
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Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients. J Transl Med. 2020 05 18; 18(1):203.
Rogers CJ, Harman RJ, Bunnell BA, Schreiber MA, Xiang C, Wang FS, Santidrian AF, Minev BR. PMID: 32423449; PMCID: PMC7232924.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Tumor growth inhibition by mSTEAP peptide nanovaccine inducing augmented CD8+ T cell immune responses. Drug Deliv Transl Res. 2019 12; 9(6):1095-1105.
Chen Q, Bao Y, Burner D, Kaushal S, Zhang Y, Mendoza T, Bouvet M, Ozkan C, Minev B, Ma W. PMID: 31228097.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells. J Transl Med. 2019 08 19; 17(1):271.
Minev BR, Lander E, Feller JF, Berman M, Greenwood BM, Minev I, Santidrian AF, Nguyen D, Draganov D, Killinc MO, Vyalkova A, Kesari S, McClay E, Carabulea G, Marincola FM, Butterfield LH, Szalay AA. PMID: 31426803; PMCID: PMC6699108.
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PubMed Mentions:
23 Fields:
Translation:
HumansCellsCTClinical Trials
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Delivery of oncolytic vaccinia virus by matched allogeneic stem cells overcomes critical innate and adaptive immune barriers. J Transl Med. 2019 03 27; 17(1):100.
Draganov DD, Santidrian AF, Minev I, Nguyen D, Kilinc MO, Petrov I, Vyalkova A, Lander E, Berman M, Minev B, Szalay AA. PMID: 30917829; PMCID: PMC6437877.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Epithelial membrane protein 2: a novel biomarker for circulating tumor cell recovery in breast cancer. Clin Transl Oncol. 2019 Apr; 21(4):433-442.
Chen Q, Yao L, Burner D, Minev B, Lu L, Wang M, Ma W. PMID: 30218306.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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The ratio of ADSCs to HSC-progenitors in adipose tissue derived SVF may provide the key to predict the outcome of stem-cell therapy. Clin Transl Med. 2018 Feb 07; 7(1):5.
Kilinc MO, Santidrian A, Minev I, Toth R, Draganov D, Nguyen D, Lander E, Berman M, Minev B, Szalay AA. PMID: 29417261; PMCID: PMC5803165.
View in:
PubMed Mentions:
21 Fields:
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Artificial human antigen-presenting cells are superior to dendritic cells at inducing cytotoxic T-cell responses. Immunology. 2017 11; 152(3):462-471.
Li H, Shao S, Cai J, Burner D, Lu L, Chen Q, Minev B, Ma W. PMID: 28664991; PMCID: PMC5629434.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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IFNγ enhances cytotoxic efficiency of the cytotoxic T lymphocytes against human glioma cells. Int Immunopharmacol. 2017 Jun; 47:159-165.
Shao S, Risch E, Burner D, Lu L, Minev B, Ma W. PMID: 28410529.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Humanized Mice with Subcutaneous Human Solid Tumors for Immune Response Analysis of Vaccinia Virus-Mediated Oncolysis. Mol Ther Oncolytics. 2017 Jun 16; 5:41-61.
Tsoneva D, Minev B, Frentzen A, Zhang Q, Wege AK, Szalay AA. PMID: 28480327; PMCID: PMC5415323.
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PubMed Mentions:
19
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Colonization of xenograft tumors by oncolytic vaccinia virus (VACV) results in enhanced tumor killing due to the involvement of myeloid cells. J Transl Med. 2016 12 20; 14(1):340.
Kilinc MO, Ehrig K, Pessian M, Minev BR, Szalay AA. PMID: 27993141; PMCID: PMC5168712.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Expression of anti-VEGF antibody together with anti-EGFR or anti-FAP enhances tumor regression as a result of vaccinia virotherapy. Mol Ther Oncolytics. 2015; 2:15003.
Huang T, Wang H, Chen NG, Frentzen A, Minev B, Szalay AA. PMID: 27119102; PMCID: PMC4782963.
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PubMed Mentions:
20
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Overcoming tumor immune evasion with an unique arbovirus. J Transl Med. 2015 Jan 16; 13:3.
Lyday B, Chen T, Kesari S, Minev B. PMID: 25592450; PMCID: PMC4307212.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant. J Transl Med. 2014 Aug 14; 12:211.
Saenz R, Futalan D, Leutenez L, Eekhout F, Fecteau JF, Sundelius S, Sundqvist S, Larsson M, Hayashi T, Minev B, Carson D, Esener S, Messmer B, Messmer D. PMID: 25123824; PMCID: PMC4261565.
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PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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Intravenous ascorbic acid as an adjuvant to interleukin-2 immunotherapy. J Transl Med. 2014 May 13; 12:127.
Wagner SC, Markosian B, Ajili N, Dolan BR, Kim AJ, Alexandrescu DT, Dasanu CA, Minev B, Koropatnick J, Marincola FM, Riordan NH. PMID: 24884532; PMCID: PMC4028098.
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PubMed Mentions:
4 Fields:
Translation:
Humans
-
Optical detection and virotherapy of live metastatic tumor cells in body fluids with vaccinia strains. PLoS One. 2013; 8(9):e71105.
Wang H, Chen NG, Minev BR, Zimmermann M, Aguilar RJ, Zhang Q, Sturm JB, Fend F, Yu YA, Cappello J, Lauer UM, Szalay AA. PMID: 24019862; PMCID: PMC3760980.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Biotherapeutic approaches to target cancer stem cells. J Stem Cells. 2013; 8(3-4):135-49.
Duggal R, Minev B, Geissinger U, Wang H, Chen NG, Koka PS, Szalay AA. PMID: 24699023.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Functional role of solid tumor stem cells in disease etiology and susceptibility to therapeutic interventions. J Stem Cells. 2013; 8(3-4):189-231.
Ramdass B, Duggal R, Minev B, Chowdhary A, Koka P. PMID: 24699025.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Oncolytic vaccinia virus GLV-1h68 strain shows enhanced replication in human breast cancer stem-like cells in comparison to breast cancer cells. J Transl Med. 2012 Aug 17; 10:167.
Wang H, Chen NG, Minev BR, Szalay AA. PMID: 22901246; PMCID: PMC3478222.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Characterization of iNOS(+) Neutrophil-like ring cell in tumor-bearing mice. J Transl Med. 2012 Jul 30; 10:152.
Virtuoso LP, Harden JL, Sotomayor P, Sigurdson WJ, Yoshimura F, Egilmez NK, Minev B, Kilinc MO. PMID: 22846631; PMCID: PMC3478162.
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PubMed Mentions:
7 Fields:
Translation:
Animals
-
PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses. Int J Nanomedicine. 2012; 7:1475-87.
Ma W, Chen M, Kaushal S, McElroy M, Zhang Y, Ozkan C, Bouvet M, Kruse C, Grotjahn D, Ichim T, Minev B. PMID: 22619507; PMCID: PMC3356185.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Autologous stromal vascular fraction therapy for rheumatoid arthritis: rationale and clinical safety. Int Arch Med. 2012 Feb 08; 5:5.
Rodriguez JP, Murphy MP, Hong S, Madrigal M, March KL, Minev B, Harman RJ, Chen CS, Timmons RB, Marleau AM, Riordan NH. PMID: 22313603; PMCID: PMC3296619.
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PubMed Mentions:
14
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Enhanced presentation of MHC class Ia, Ib and class II-restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy. J Transl Med. 2011 Mar 31; 9:34.
Ma W, Smith T, Bogin V, Zhang Y, Ozkan C, Ozkan M, Hayden M, Schroter S, Carrier E, Messmer D, Kumar V, Minev B. PMID: 21450109; PMCID: PMC3078865.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Intravenous ascorbic acid to prevent and treat cancer-associated sepsis? J Transl Med. 2011 Mar 04; 9:25.
Ichim TE, Minev B, Braciak T, Luna B, Hunninghake R, Mikirova NA, Jackson JA, Gonzalez MJ, Miranda-Massari JR, Alexandrescu DT, Dasanu CA, Bogin V, Ancans J, Stevens RB, Markosian B, Koropatnick J, Chen CS, Riordan NH. PMID: 21375761; PMCID: PMC3061919.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report. Int Arch Med. 2010 Nov 11; 3:30.
Ichim TE, Solano F, Lara F, Paris E, Ugalde F, Rodriguez JP, Minev B, Bogin V, Ramos F, Woods EJ, Murphy MP, Patel AN, Harman RJ, Riordan NH. PMID: 21070647; PMCID: PMC2989319.
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PubMed Mentions:
34
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Safety evaluation of allogeneic umbilical cord blood mononuclear cell therapy for degenerative conditions. J Transl Med. 2010 Aug 03; 8:75.
Yang WZ, Zhang Y, Wu F, Min WP, Minev B, Zhang M, Luo XL, Ramos F, Ichim TE, Riordan NH, Hu X. PMID: 20682053; PMCID: PMC2922090.
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PubMed Mentions:
29 Fields:
Translation:
HumansCTClinical Trials
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Combination stem cell therapy for heart failure. Int Arch Med. 2010 Apr 14; 3(1):5.
Ichim TE, Solano F, Lara F, Rodriguez JP, Cristea O, Minev B, Ramos F, Woods EJ, Murphy MP, Alexandrescu DT, Patel AN, Riordan NH. PMID: 20398245; PMCID: PMC3003238.
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PubMed Mentions:
21
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Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects. J Transl Med. 2010 Apr 08; 8:34.
Mikirova NA, Jackson JA, Hunninghake R, Kenyon J, Chan KW, Swindlehurst CA, Minev B, Patel AN, Murphy MP, Smith L, Ramos F, Ichim TE, Riordan NH. PMID: 20377846; PMCID: PMC2862021.
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PubMed Mentions:
5 Fields:
Translation:
HumansCellsCTClinical Trials
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Autologous stromal vascular fraction cells: a tool for facilitating tolerance in rheumatic disease. Cell Immunol. 2010; 264(1):7-17.
Ichim TE, Harman RJ, Min WP, Minev B, Solano F, Rodriguez JP, Alexandrescu DT, De Necochea-Campion R, Hu X, Marleau AM, Riordan NH. PMID: 20537320.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Delivery of a peptide via poly(D,L-lactic-co-glycolic) acid nanoparticles enhances its dendritic cell-stimulatory capacity. Nanomedicine. 2010 Oct; 6(5):651-61.
Clawson C, Huang CT, Futalan D, Seible DM, Saenz R, Larsson M, Ma W, Minev B, Zhang F, Ozkan M, Ozkan C, Esener S, Messmer D. PMID: 20348031; PMCID: PMC2947606.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Induction characterization and targeting of human hematopoietic cancer stem cells. J Stem Cells. 2010; 5(1):1-7.
Zhang M, Dias P, Minev B, Koka PS. PMID: 20861923.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Circulating endothelial progenitor cells: a new approach to anti-aging medicine? J Transl Med. 2009 Dec 15; 7:106.
Mikirova NA, Jackson JA, Hunninghake R, Kenyon J, Chan KW, Swindlehurst CA, Minev B, Patel AN, Murphy MP, Smith L, Alexandrescu DT, Ichim TE, Riordan NH. PMID: 20003528; PMCID: PMC2804590.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis. J Transl Med. 2009 Apr 24; 7:29.
Riordan NH, Ichim TE, Min WP, Wang H, Solano F, Lara F, Alfaro M, Rodriguez JP, Harman RJ, Patel AN, Murphy MP, Lee RR, Minev B. PMID: 19393041; PMCID: PMC2679713.
View in:
PubMed Mentions:
108 Fields:
Translation:
HumansAnimalsCells
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Human embryonic stem cells hemangioblast express HLA-antigens. J Transl Med. 2009 Apr 22; 7:27.
Basak GW, Yasukawa S, Alfaro A, Halligan S, Srivastava AS, Min WP, Minev B, Carrier E. PMID: 19386101; PMCID: PMC2680830.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Feasibility investigation of allogeneic endometrial regenerative cells. J Transl Med. 2009 Feb 20; 7:15.
Zhong Z, Patel AN, Ichim TE, Riordan NH, Wang H, Min WP, Woods EJ, Reid M, Mansilla E, Marin GH, Drago H, Murphy MP, Minev B. PMID: 19232091; PMCID: PMC2649897.
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PubMed Mentions:
68 Fields:
Translation:
HumansCells
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Inhibition of intracranial glioma growth by endometrial regenerative cells. Cell Cycle. 2009 Feb 15; 8(4):606-10.
Han X, Meng X, Yin Z, Rogers A, Zhong J, Rillema P, Jackson JA, Ichim TE, Minev B, Carrier E, Patel AN, Murphy MP, Min WP, Riordan NH. PMID: 19197154.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimals
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Exosomes as a tumor immune escape mechanism: possible therapeutic implications. J Transl Med. 2008 Jul 22; 6:37.
Ichim TE, Zhong Z, Kaushal S, Zheng X, Ren X, Hao X, Joyce JA, Hanley HH, Riordan NH, Koropatnick J, Bogin V, Minev BR, Min WP, Tullis RH. PMID: 18644158; PMCID: PMC2504474.
View in:
PubMed Mentions:
52 Fields:
Translation:
HumansCells
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Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. Clin Cancer Res. 2007 Jan 15; 13(2 Pt 1):566-575.
Zhang JG, Eguchi J, Kruse CA, Gomez GG, Fakhrai H, Schroter S, Ma W, Hoa N, Minev B, Delgado C, Wepsic HT, Okada H, Jadus MR. PMID: 17255279; PMCID: PMC4030524.
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PubMed Mentions:
89 Fields:
Translation:
HumansCells
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Dendritic cell activating peptides induce distinct cytokine profiles. Int Immunol. 2006 Nov; 18(11):1563-73.
Telusma G, Datta S, Mihajlov I, Ma W, Li J, Yang H, Newman W, Messmer BT, Minev B, Schmidt-Wolf IG, Tracey KJ, Chiorazzi N, Messmer D. PMID: 16966494.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Preparation of murine B7.1-glycosylphosphatidylinositol and transmembrane-anchored staphylococcal enterotoxin. A dual-anchored tumor cell vaccine and its antitumor effect. Cancer. 2005 Apr 01; 103(7):1519-28.
Yi P, Yu H, Ma W, Wang Q, Minev BR. PMID: 15739200.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Chimerism and tolerance post-in utero transplantation with embryonic stem cells. Transplantation. 2004 Nov 15; 78(9):1274-82.
Moustafa ME, Srivastava AS, Nedelcu E, Donahue J, Gueorguieva I, Shenouda SS, Minev B, Carrier E. PMID: 15548963.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals
-
Technology evaluation: HSPPC-96, antigenics. Curr Opin Mol Ther. 2003 Dec; 5(6):680-7.
Minev BR. PMID: 14755896.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Immunotherapy and prostate cancer. Cancer Treat Rev. 2003 Jun; 29(3):199-209.
Kaminski JM, Summers JB, Ward MB, Huber MR, Minev B. PMID: 12787714.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
-
Vaccines for immunotherapy of breast cancer and prostate cancer: new developments and comparative aspects. In Vivo. 2002 Nov-Dec; 16(6):405-15.
Minev BR, Guo F, Gueorguieva I, Kaiser HE. PMID: 12494883.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
-
Melanoma vaccines. Semin Oncol. 2002 Oct; 29(5):479-93.
Minev BR. PMID: 12407513.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Conjugates of aberrant gangliosides in antiglioma vaccine: toxicological assay. Bull Exp Biol Med. 2002 Oct; 134(4):363-5.
Lombardi V, Shnaar R, Minev B, Misasi R, Gitstsi Kh, Sorice M, Troncone A. PMID: 12533760.
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PubMed Mentions: Fields:
Translation:
Animals
-
A novel melanoma gene (MG50) encoding the interleukin 1 receptor antagonist and six epitopes recognized by human cytolytic T lymphocytes. Cancer Res. 2000 Nov 15; 60(22):6448-56.
Mitchell MS, Kan-Mitchell J, Minev B, Edman C, Deans RJ. PMID: 11103812.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Cancer vaccines: an update. In Vivo. 2000 Sep-Oct; 14(5):571-85.
Hipp JD, Hipp JA, Lyday BW, Minev BR. PMID: 11125541.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Synthetic insertion signal sequences enhance MHC class I presentation of a peptide from the melanoma antigen MART-1. Eur J Immunol. 2000 Aug; 30(8):2115-24.
Minev BR, Chavez FL, Dudouet BM, Mitchell MS. PMID: 10940901.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Cytotoxic T cell immunity against telomerase reverse transcriptase in humans. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4796-801.
Minev B, Hipp J, Firat H, Schmidt JD, Langlade-Demoyen P, Zanetti M. PMID: 10759561; PMCID: PMC18312.
View in:
PubMed Mentions:
69 Fields:
Translation:
HumansAnimalsCells
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Cancer vaccines: novel approaches and new promise. Pharmacol Ther. 1999 Feb; 81(2):121-39.
Minev BR, Chavez FL, Mitchell MS. PMID: 10190583.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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New trends in the development of cancer vaccines. In Vivo. 1998 Nov-Dec; 12(6):629-38.
Minev BR, Chavez FL, Mitchell MS. PMID: 9891226.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Insertion signal sequence fused to minimal peptides elicits specific CD8+ T-cell responses and prolongs survival of thymoma-bearing mice. Cancer Res. 1994 Aug 01; 54(15):4155-61.
Minev BR, McFarland BJ, Spiess PJ, Rosenberg SA, Restifo NP. PMID: 7518351; PMCID: PMC2254935.
View in:
PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Enhancing the recognition of tumour associated antigens. Folia Biol (Praha). 1994; 40(1-2):74-88.
Restifo NP, Minev BR, Taggarse AS, McFarland BJ, Wang M, Irvine KR. PMID: 7958066; PMCID: PMC2763578.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells