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James Covell

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0613-J
La Jolla CA 92093
Phone858-453-5489
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular biology and mechanics of the cardiac interstitium
    NIH/NHLBI R01HL043617Jul 1, 1989 - Mar 31, 2013
    Role: Co-Principal Investigator
    Transmural Deformation
    NIH/NHLBI R01HL032583Jul 1, 1984 - Jun 30, 2010
    Role: Co-Principal Investigator
    Training In Cardiovascular Physiology & Pharmacology
    NIH/NHLBI T32HL007444Jul 1, 1979 - Jun 30, 2018
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ito BR, Covell J, Curtis GP. Low Intensity Epicardial Pacing During the Absolute Refractory Period Augments Left Ventricular Function Mediated by Local Catecholamine Release. J Cardiovasc Electrophysiol. 2016 Sep; 27(9):1102-9. PMID: 27279561.
      View in: PubMed
    2. Howard EJ, Covell J, Mulligan LJ, McCulloch AD, Omens JH, Kerckhoffs RC. Improvement in pump function with endocardial biventricular pacing increases with activation time at the left ventricular pacing site in failing canine hearts. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1447-55. PMID: 21784986; PMCID: PMC3197362.
    3. Covell J. Tissue structure and ventricular wall mechanics. Circulation. 2008 Aug 12; 118(7):699-701. PMID: 18695201.
      View in: PubMed
    4. Ashikaga H, Coppola BA, Yamazaki KG, Villarreal FJ, Omens JH, Covell J. Changes in regional myocardial volume during the cardiac cycle: implications for transmural blood flow and cardiac structure. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H610-8. PMID: 18515651; PMCID: PMC2519196.
    5. Coppola BA, Covell J, McCulloch AD, Omens JH. Asynchrony of ventricular activation affects magnitude and timing of fiber stretch in late-activated regions of the canine heart. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H754-61. PMID: 17449547; PMCID: PMC3328414.
    6. Kassab GS, Kostelec M, Buckberg GD, Covell J, Sadeghi A, Hoffman JI. Myocardial protection in the failing heart: II. Effect of pulsatile cardioplegic perfusion under simulated left ventricular restoration. J Thorac Cardiovasc Surg. 2006 Oct; 132(4):884-90. PMID: 17000301.
      View in: PubMed
    7. Kostelec M, Covell J, Buckberg GD, Sadeghi A, Hoffman JI, Kassab GS. Myocardial protection in the failing heart: I. Effect of cardioplegia and the beating state under simulated left ventricular restoration. J Thorac Cardiovasc Surg. 2006 Oct; 132(4):875-83. PMID: 17000300.
      View in: PubMed
    8. Weis SM, Zimmerman SD, Shah M, Covell J, Omens JH, Ross J, Dalton N, Jones Y, Reed CC, Iozzo RV, McCulloch AD. A role for decorin in the remodeling of myocardial infarction. Matrix Biol. 2005 Jun; 24(4):313-24. PMID: 15949932.
      View in: PubMed
    9. Ashikaga H, Covell J, Omens JH. Diastolic dysfunction in volume-overload hypertrophy is associated with abnormal shearing of myolaminar sheets. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2603-10. PMID: 15708954; PMCID: PMC2822838.
    10. Holmes JW, Borg TK, Covell J. Structure and mechanics of healing myocardial infarcts. Annu Rev Biomed Eng. 2005; 7:223-53. PMID: 16004571.
      View in: PubMed
    11. GarcĂ­a RA, Brown KL, Pavelec RS, Go KV, Covell J, Villarreal FJ. Abnormal cardiac wall motion and early matrix metalloproteinase activity. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3):H1080-7. PMID: 15486029.
      View in: PubMed
    12. Rodriguez F, Langer F, Harrington KB, Tibayan FA, Zasio MK, Cheng A, Liang D, Daughters GT, Covell J, Criscione JC, Ingels NB, Miller DC. Importance of mitral valve second-order chordae for left ventricular geometry, wall thickening mechanics, and global systolic function. Circulation. 2004 Sep 14; 110(11 Suppl 1):II115-22. PMID: 15364849.
      View in: PubMed
    13. Zimmerman SD, Criscione J, Covell J. Remodeling in myocardium adjacent to an infarction in the pig left ventricle. Am J Physiol Heart Circ Physiol. 2004 Dec; 287(6):H2697-704. PMID: 15319211.
      View in: PubMed
    14. Ashikaga H, Omens JH, Covell J. Time-dependent remodeling of transmural architecture underlying abnormal ventricular geometry in chronic volume overload heart failure. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H1994-2002. PMID: 15242833; PMCID: PMC2842928.
    15. Villarreal F, Omens J, Dillmann W, Risteli J, Nguyen J, Covell J. Early degradation and serum appearance of type I collagen fragments after myocardial infarction. J Mol Cell Cardiol. 2004 Apr; 36(4):597-601. PMID: 15081319.
      View in: PubMed
    16. Ashikaga H, Omens JH, Ingels NB, Covell J. Transmural mechanics at left ventricular epicardial pacing site. Am J Physiol Heart Circ Physiol. 2004 Jun; 286(6):H2401-7. PMID: 14751858; PMCID: PMC2965026.
    17. Ashikaga H, Criscione JC, Omens JH, Covell J, Ingels NB. Transmural left ventricular mechanics underlying torsional recoil during relaxation. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(2):H640-7. PMID: 14551052; PMCID: PMC2954110.
    18. Villarreal FJ, Griffin M, Omens J, Dillmann W, Nguyen J, Covell J. Early short-term treatment with doxycycline modulates postinfarction left ventricular remodeling. Circulation. 2003 Sep 23; 108(12):1487-92. PMID: 12952845.
      View in: PubMed
    19. Takayama Y, Costa KD, Covell J. Contribution of laminar myofiber architecture to load-dependent changes in mechanics of LV myocardium. Am J Physiol Heart Circ Physiol. 2002 Apr; 282(4):H1510-20. PMID: 11893589.
      View in: PubMed