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    Robert Ross

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0613C
    CA La Jolla 92093
    Phone858-246-0624
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      Collapse Research 
      Collapse Research Activities and Funding
      Costamere Structure, Membrane Stability and Integrin Trafficking in the Normal and Diseased Heart
      VA I01BX003260Apr 1, 2016 - Mar 31, 2020
      Role: Principal Investigator
      Cardiac Myocyte Form and Function: Role of Talin and Kindlin
      NIH/NHLBI R01HL127806Jul 1, 2015 - Jun 30, 2019
      Role: Principal Investigator
      Diversity in Research and Medicine
      NIH/NHLBI R25HL120892Apr 1, 2014 - Mar 31, 2019
      Role: Principal Investigator
      Integrins and Caveolin Proteins in Cardiac Hypertrophy and Failure
      NIH/NHLBI R01HL115933Sep 1, 2013 - May 31, 2017
      Role: Principal Investigator
      Replacement of Small Animal Echocardiographic Instrumentation
      NIH S10OD010417Jun 5, 2012 - Jun 4, 2013
      Role: Principal Investigator
      Beta-1 Integrin and Caveolin-3 in Cardiac Mechanotransduction
      VA I01BX001704Apr 1, 2012 - Mar 31, 2016
      Role: Principal Investigator
      Cardiomyocyte mechanotransduction through the integrin complex
      NIH/NHLBI R01HL103566Jul 15, 2010 - Apr 30, 2015
      Role: Principal Investigator
      Integrin Function in Cardiac Remodeling
      NIH/NHLBI R01HL088390Apr 1, 2008 - Mar 31, 2012
      Role: Principal Investigator
      MSTP Summer Undergraduate Research Fellowship (SURF)
      NIH/NHLBI R25HL084692Aug 21, 2006 - Jul 31, 2013
      Role: Principal Investigator
      Vinculin and Metavinculin Function in the Myocardium
      NIH/NHLBI R01HL073393Apr 18, 2003 - Mar 31, 2007
      Role: Principal Investigator
      BI Integrins Signaling During Cardiogenesis &Growth
      NIH/NHLBI R01HL057872Aug 1, 1996 - Jul 31, 2006
      Role: Principal Investigator
      Molecular Pathways for Hypertrophy and Cardiomyopathy
      NIH/NHLBI P01HL046345Feb 1, 1992 - Jun 30, 2014
      Role: Co-Investigator
      Training In Cardiovascular Physiology & Pharmacology
      NIH/NHLBI T32HL007444Jul 1, 1979 - Jun 30, 2018
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Manso AM, Okada H, Sakamoto FM, Moreno E, Monkley SJ, Li R, Critchley DR, Ross R. Loss of mouse cardiomyocyte talin-1 and talin-2 leads to ß-1 integrin reduction, costameric instability, and dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2017 Jul 25; 114(30):E6250-E6259. PMID: 28698364.
        View in: PubMed
      2. Ichikawa Y, Zemljic-Harpf AE, Zhang Z, McKirnan MD, Manso AM, Ross R, Hammond HK, Patel HH, Roth DM. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits. PLoS One. 2017; 12(5):e0177660. PMID: 28498861.
        View in: PubMed
      3. Ma X, Chen C, Veevers J, Zhou X, Ross R, Feng W, Chen J. CRISPR/Cas9-mediated gene manipulation to create single-amino-acid-substituted and floxed mice with a cloning-free method. Sci Rep. 2017 Feb 08; 7:42244. PMID: 28176880.
        View in: PubMed
      4. Zhang Z, Mu Y, Veevers J, Peter AK, Manso AM, Bradford WH, Dalton ND, Peterson KL, Knowlton KU, Ross R, Zhou X, Chen J. Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure. Circ Heart Fail. 2016 Aug; 9(8). PMID: 27502369; PMCID: PMC4979611 [Available on 08/01/17].
      5. Chen C, Li R, Ross R, Manso AM. Integrins and integrin-related proteins in cardiac fibrosis. J Mol Cell Cardiol. 2016 Apr; 93:162-74. PMID: 26562414; PMCID: PMC4846493 [Available on 04/01/17].
      6. Israeli-Rosenberg S, Chen C, Li R, Deussen DN, Niesman IR, Okada H, Patel HH, Roth DM, Ross R. Caveolin modulates integrin function and mechanical activation in the cardiomyocyte. FASEB J. 2015 Feb; 29(2):374-84. PMID: 25366344; PMCID: PMC4314226.
      7. Zemljic-Harpf AE, Godoy JC, Platoshyn O, Asfaw EK, Busija AR, Domenighetti AA, Ross R. Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes. J Cell Sci. 2014 Mar 01; 127(Pt 5):1104-16. PMID: 24413171; PMCID: PMC3937777.
      8. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross R. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. PMID: 24091324; PMCID: PMC3784521.
      9. Tangney JR, Chuang JS, Janssen MS, Krishnamurthy A, Liao P, Hoshijima M, Wu X, Meininger GA, Muthuchamy M, Zemljic-Harpf A, Ross R, Frank LR, McCulloch AD, Omens JH. Novel role for vinculin in ventricular myocyte mechanics and dysfunction. Biophys J. 2013 Apr 02; 104(7):1623-33. PMID: 23561539; PMCID: PMC3617425.
      10. Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross R. Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. J Biol Chem. 2013 Feb 08; 288(6):4252-64. PMID: 23266827; PMCID: PMC3567677.
      11. Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross R, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth DM, Insel PA, Patel HH. Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J. 2012 Nov; 26(11):4637-49. PMID: 22859372; PMCID: PMC4050367.
      12. Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross R, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ. New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2. Eur J Cell Biol. 2012 Mar; 91(3):180-91. PMID: 22306379; PMCID: PMC3629562.
      13. Li R, Wu Y, Manso AM, Gu Y, Liao P, Israeli S, Yajima T, Nguyen U, Huang MS, Dalton ND, Peterson KL, Ross R. ß1 integrin gene excision in the adult murine cardiac myocyte causes defective mechanical and signaling responses. Am J Pathol. 2012 Mar; 180(3):952-62. PMID: 22248583; PMCID: PMC3349893.
      14. Peter AK, Cheng H, Ross R, Knowlton KU, Chen J. The costamere bridges sarcomeres to the sarcolemma in striated muscle. Prog Pediatr Cardiol. 2011 May; 31(2):83-88. PMID: 24039381.
        View in: PubMed
      15. Chuang JS, Zemljic-Harpf A, Ross R, Frank LR, McCulloch AD, Omens JH. Determination of three-dimensional ventricular strain distributions in gene-targeted mice using tagged MRI. Magn Reson Med. 2010 Nov; 64(5):1281-8. PMID: 20981782; PMCID: PMC3272305.
      16. Zemljic-Harpf A, Manso AM, Ross R. Vinculin and talin: focus on the myocardium. J Investig Med. 2009 Dec; 57(8):849-55. PMID: 19952892; PMCID: PMC2810504.
      17. Manso AM, Kang SM, Ross R. Integrins, focal adhesions, and cardiac fibroblasts. J Investig Med. 2009 Dec; 57(8):856-60. PMID: 19952893; PMCID: PMC2810503.
      18. Sheikh F, Ross R, Chen J. Cell-cell connection to cardiac disease. Trends Cardiovasc Med. 2009 Aug; 19(6):182-90. PMID: 20211433; PMCID: PMC3601820.
      19. Manso AM, Kang SM, Plotnikov SV, Thievessen I, Oh J, Beggs HE, Ross R. Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H627-38. PMID: 19136609; PMCID: PMC2660223.
      20. Elsherif L, Huang MS, Shai SY, Yang Y, Li RY, Chun J, Mekany MA, Chu AL, Kaufman SJ, Ross R. Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification. Circ Res. 2008 May 09; 102(9):1109-17. PMID: 18340010.
        View in: PubMed
      21. Ross R, Chen J. Models that Buzz, Squeak, Ribbit and Oink: Using a Variety of Species to Study Cardiovascular Disease. Drug Discov Today Dis Models. 2008; 5(3):113-115. PMID: 19802370.
        View in: PubMed
      22. Zemljic-Harpf AE, Miller JC, Henderson SA, Wright AT, Manso AM, Elsherif L, Dalton ND, Thor AK, Perkins GA, McCulloch AD, Ross R. Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol. 2007 Nov; 27(21):7522-37. PMID: 17785437; PMCID: PMC2169049.
      23. Manso AM, Elsherif L, Kang SM, Ross R. Integrins, membrane-type matrix metalloproteinases and ADAMs: potential implications for cardiac remodeling. Cardiovasc Res. 2006 Feb 15; 69(3):574-84. PMID: 16253214.
        View in: PubMed
      24. Zemljic-Harpf AE, Ponrartana S, Avalos RT, Jordan MC, Roos KP, Dalton ND, Phan VQ, Adamson ED, Ross R. Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy. Am J Pathol. 2004 Sep; 165(3):1033-44. PMID: 15331426; PMCID: PMC1618594.
      25. Ross R. Molecular and mechanical synergy: cross-talk between integrins and growth factor receptors. Cardiovasc Res. 2004 Aug 15; 63(3):381-90. PMID: 15276463.
        View in: PubMed
      26. Ross R. The extracellular connections: the role of integrins in myocardial remodeling. J Card Fail. 2002 Dec; 8(6 Suppl):S326-31. PMID: 12555140.
        View in: PubMed
      27. Shai SY, Harpf AE, Babbitt CJ, Jordan MC, Fishbein MC, Chen J, Omura M, Leil TA, Becker KD, Jiang M, Smith DJ, Cherry SR, Loftus JC, Ross R. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res. 2002 Mar 08; 90(4):458-64. PMID: 11884376.
        View in: PubMed
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