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    Adriana Tremoulet

    TitleAssociate Professor Of Clinical
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0641
    CA La Jolla 92093
    Phone858-246-0012
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      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
      NIH/NICHD U54HD090259Sep 20, 2016 - Jun 30, 2021
      Role: Principal Investigator
      Developing Pediatric Clinical Pharmacologists for the Advancement of Therapeutics
      NIH/NICHD T32HD087978May 1, 2016 - Apr 30, 2021
      Role: Principal Investigator
      Phase I and IIa trial of atorvastatin in children with acute Kawasaki disease
      NIH/NICHD R01HD081296Sep 23, 2014 - Jun 30, 2018
      Role: Principal Investigator
      Pharmacologic Determinants for Optimized Therapy in HIV-Infected Children
      NIH/NICHD K23HD056939Sep 1, 2007 - Aug 31, 2013
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Lee B, Kofman CD, Tremoulet A, Kuo DJ. Fever without a source: evolution of a diagnosis from Kawasaki disease to acute myelogenous leukaemia. BMJ Case Rep. 2017 May 06; 2017. PMID: 28478386.
        View in: PubMed
      2. Salgado AP, Ashouri N, Berry EK, Sun X, Jain S, Burns JC, Tremoulet A. High Risk of Coronary Artery Aneurysms in Infants Younger than 6 Months of Age with Kawasaki Disease. J Pediatr. 2017 Jun; 185:112-116.e1. PMID: 28408126.
        View in: PubMed
      3. Kim J, Shimizu C, Kingsmore SF, Veeraraghavan N, Levy E, Ribeiro Dos Santos AM, Yang H, Flatley J, Hoang LT, Hibberd ML, Tremoulet A, Harismendy O, Ohno-Machado L, Burns JC. Whole genome sequencing of an African American family highlights toll like receptor 6 variants in Kawasaki disease susceptibility. PLoS One. 2017; 12(2):e0170977. PMID: 28151979.
        View in: PubMed
      4. Wang Y, Li Z, Hu G, Hao S, Deng X, Huang M, Ren M, Jiang X, Kanegaye JT, Ha KS, Lee J, Li X, Jiang X, Yu Y, Tremoulet A, Burns JC, Whitin JC, Shin AY, Sylvester KG, McElhinney DB, Cohen HJ, Ling XB. Unique Molecular Patterns Uncovered in Kawasaki Disease Patients with Elevated Serum Gamma Glutamyl Transferase Levels: Implications for Intravenous Immunoglobulin Responsiveness. PLoS One. 2016; 11(12):e0167434. PMID: 28002448.
        View in: PubMed
      5. He M, Chen Z, Martin M, Zhang J, Sangwung P, Woo B, Tremoulet A, Shimizu C, Jain MK, Burns JC, Shyy J. miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease. Circ Res. 2016 Dec 06. PMID: 27923814.
        View in: PubMed
      6. Lee AM, Burns JC, Tremoulet A. Safety of Infliximab Following Live Virus Vaccination in Kawasaki Disease Patients. Pediatr Infect Dis J. 2016 Dec 01. PMID: 27918378.
        View in: PubMed
      7. Shimizu C, Eleftherohorinou H, Wright VJ, Kim J, Alphonse MP, Perry JC, Cimaz R, Burgner D, Dahdah N, Hoang LT, Khor CC, Salgado A, Tremoulet A, Davila S, Kuijpers TW, Hibberd ML, Johnson TA, Takahashi A, Tsunoda T, Kubo M, Tanaka T, Onouchi Y, Yeung RS, Coin LJ, Levin M, Burns JC. Genetic Variation in the SLC8A1 Calcium Signaling Pathway Is Associated with Susceptibility to Kawasaki Disease and Coronary Artery Abnormalities. Circ Cardiovasc Genet. 2016 Nov 21. PMID: 27879314.
        View in: PubMed
      8. Burns JC, Koné-Paut I, Kuijpers T, Shimizu C, Tremoulet A, Arditi M. Found in Translation: International initiatives pursuing interleukin-1 blockade for treatment of acute Kawasaki Disease. Arthritis Rheumatol. 2016 Oct 28. PMID: 27792871.
        View in: PubMed
      9. Friedman KG, Gauvreau K, Hamaoka-Okamoto A, Tang A, Berry E, Tremoulet A, Mahavadi VS, Baker A, deFerranti SD, Fulton DR, Burns JC, Newburger JW. Coronary Artery Aneurysms in Kawasaki Disease: Risk Factors for Progressive Disease and Adverse Cardiac Events in the US Population. J Am Heart Assoc. 2016 Sep; 5(9). PMID: 27633390.
        View in: PubMed
      10. Connelly MA, Shimizu C, Winegar DA, Shalaurova I, Pourfarzib R, Otvos JD, Kanegaye JT, Tremoulet A, Burns JC. Differences in GlycA and lipoprotein particle parameters may help distinguish acute kawasaki disease from other febrile illnesses in children. BMC Pediatr. 2016; 16(1):151. PMID: 27596163; PMCID: PMC5011873.
      11. Hornik CP, Benjamin DK, Smith PB, Pencina MJ, Tremoulet A, Capparelli EV, Ericson JE, Clark RH, Cohen-Wolkowiez M. Electronic Health Records and Pharmacokinetic Modeling to Assess the Relationship between Ampicillin Exposure and Seizure Risk in Neonates. J Pediatr. 2016 Nov; 178:125-129.e1. PMID: 27522443.
        View in: PubMed
      12. Herberg JA, Kaforou M, Wright VJ, Shailes H, Eleftherohorinou H, Hoggart CJ, Cebey-López M, Carter MJ, Janes VA, Gormley S, Shimizu C, Tremoulet A, Barendregt AM, Salas A, Kanegaye J, Pollard AJ, Faust SN, Patel S, Kuijpers T, Martinón-Torres F, Burns JC, Coin LJ, Levin M. Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children. JAMA. 2016 Aug 23-30; 316(8):835-45. PMID: 27552617.
        View in: PubMed
      13. Hao S, Jin B, Tan Z, Li Z, Ji J, Hu G, Wang Y, Deng X, Kanegaye JT, Tremoulet A, Burns JC, Cohen HJ, Ling XB. A Classification Tool for Differentiation of Kawasaki Disease from Other Febrile Illnesses. J Pediatr. 2016 Sep; 176:114-120.e8. PMID: 27344221; NIHMSID: NIHMS790064 [Available on 09/01/17].
        View in: PubMed
      14. Doan S, Maehara CK, Chaparro JD, Lu S, Liu R, Graham A, Berry E, Hsu CN, Kanegaye JT, Lloyd DD, Ohno-Machado L, Burns JC, Tremoulet A. Building a Natural Language Processing Tool to Identify Patients With High Clinical Suspicion for Kawasaki Disease from Emergency Department Notes. Acad Emerg Med. 2016 May; 23(5):628-36. PMID: 26826020.
        View in: PubMed
      15. Tremoulet A, Jain S, Kim S, Newburger J, Arditi M, Franco A, Best B, Burns JC. Rationale and study design for a phase I/IIa trial of anakinra in children with Kawasaki disease and early coronary artery abnormalities (the ANAKID trial). Contemp Clin Trials. 2016 May; 48:70-5. PMID: 27080929.
        View in: PubMed
      16. Haddock ES, Calame A, Shimizu C, Tremoulet A, Burns JC, Tom WL. Psoriasiform eruptions during Kawasaki disease (KD): A distinct phenotype. J Am Acad Dermatol. 2016 Jul; 75(1):69-76.e2. PMID: 26946987.
        View in: PubMed
      17. Li Z, Tan Z, Hao S, Jin B, Deng X, Hu G, Liu X, Zhang J, Jin H, Huang M, Kanegaye JT, Tremoulet A, Burns JC, Wu J, Cohen HJ, Ling XB. Urinary Colorimetric Sensor Array and Algorithm to Distinguish Kawasaki Disease from Other Febrile Illnesses. PLoS One. 2016; 11(2):e0146733. PMID: 26859297.
        View in: PubMed
      18. Kanegaye JT, Jones JM, Burns JC, Jain S, Sun X, Jimenez-Fernandez S, Berry E, Pancheri JM, Jaggi P, Ramilo O, Tremoulet A. Axillary, Oral and Rectal Routes of Temperature Measurement During Treatment of Acute Kawasaki Disease. Pediatr Infect Dis J. 2016 Jan; 35(1):50-3. PMID: 26398742.
        View in: PubMed
      19. Numano F, Shimizu C, Tremoulet A, Dyar D, Burns JC, Printz BF. Pulmonary Artery Dilation and Right Ventricular Function in Acute Kawasaki Disease. Pediatr Cardiol. 2016 Mar; 37(3):482-90. PMID: 26681305.
        View in: PubMed
      20. Jaggi P, Wang W, Dvorchik I, Printz B, Berry E, Kovalchin JP, Texter K, Ramilo O, Burns JC, Tremoulet A. Patterns of Fever in Children After Primary Treatment for Kawasaki Disease. Pediatr Infect Dis J. 2015 Dec; 34(12):1315-8. PMID: 26353031.
        View in: PubMed
      21. Tremoulet A, Dutkowski J, Sato Y, Kanegaye JT, Ling XB, Burns JC. Novel data-mining approach identifies biomarkers for diagnosis of Kawasaki disease. Pediatr Res. 2015 Nov; 78(5):547-53. PMID: 26237629.
        View in: PubMed
      22. Numano F, Shimizu C, Jimenez-Fernandez S, Vejar M, Oharaseki T, Takahashi K, Salgado A, Tremoulet A, Gordon JB, Burns JC, Daniels LB. Galectin-3 is a marker of myocardial and vascular fibrosis in Kawasaki disease patients with giant aneurysms. Int J Cardiol. 2015 Dec 15; 201:429-37. PMID: 26313861.
        View in: PubMed
      23. Tremoulet A, Jain S, Burns JC. Evaluating a novel treatment for coronary artery inflammation in acute Kawasaki disease: A Phase I/IIa trial of atorvastatin. Expert Opin Orphan Drugs. 2015; 3(9):967-970. PMID: 27525197.
        View in: PubMed
      24. Burns JC, Touma R, Song Y, Padilla RL, Tremoulet A, Sidney J, Sette A, Franco A. Fine specificities of natural regulatory T cells after IVIG therapy in patients with Kawasaki disease. Autoimmunity. 2015 May; 48(3):181-8. PMID: 25822882.
        View in: PubMed
      25. Tremoulet A. The role of statins in inflammatory vasculitides. Autoimmunity. 2015 May; 48(3):177-80. PMID: 25822883.
        View in: PubMed
      26. Hoang LT, Shimizu C, Ling L, Naim AN, Khor CC, Tremoulet A, Wright V, Levin M, Hibberd ML, Burns JC. Global gene expression profiling identifies new therapeutic targets in acute Kawasaki disease. Genome Med. 2014; 6(11):541. PMID: 25614765.
        View in: PubMed
      27. Ulloa-Gutierrez R, Salgado AP, Tremoulet A. Kawasaki Disease in Latin American Children: Past, Current, and Future Challenges. J Pediatric Infect Dis Soc. 2014 Dec; 3(4):280-1. PMID: 26625447.
        View in: PubMed
      28. Chao T, Perry JC, Romanowski GL, Tremoulet A, Capparelli EV. Optimizing pediatric esmolol dosing using computerized practitioner order entry. J Pediatr Pharmacol Ther. 2014 Oct-Dec; 19(4):302-9. PMID: 25762876.
        View in: PubMed
      29. Lin J, Jain S, Sun X, Liu V, Sato YZ, Jimenez-Fernandez S, Newfield RS, Pourfarzib R, Tremoulet A, Gordon JB, Daniels LB, Burns JC. Lipoprotein Particle Concentrations in Children and Adults following Kawasaki Disease. J Pediatr. 2014 Jul 16. PMID: 25039043.
        View in: PubMed
      30. Tremoulet A, Le J, Poindexter B, Sullivan JE, Laughon M, Delmore P, Salgado A, Ian-U Chong S, Melloni C, Gao J, Benjamin DK, Capparelli EV, Cohen-Wolkowiez M. Characterization of the population pharmacokinetics of ampicillin in neonates using an opportunistic study design. Antimicrob Agents Chemother. 2014 Jun; 58(6):3013-20. PMID: 24614374.
        View in: PubMed
      31. Tremoulet A, Jain S, Jaggi P, Jimenez-Fernandez S, Pancheri JM, Sun X, Kanegaye JT, Kovalchin JP, Printz BF, Ramilo O, Burns JC. Infliximab for intensification of primary therapy for Kawasaki disease: a phase 3 randomised, double-blind, placebo-controlled trial. Lancet. 2014 May 17; 383(9930):1731-8. PMID: 24572997.
        View in: PubMed
      32. Franco A, Touma R, Song Y, Shimizu C, Tremoulet A, Kanegaye JT, Burns JC. Specificity of regulatory T cells that modulate vascular inflammation. Autoimmunity. 2014 Mar; 47(2):95-104. PMID: 24490882.
        View in: PubMed
      33. Ogata S, Shimizu C, Franco A, Touma R, Kanegaye JT, Choudhury BP, Naidu NN, Kanda Y, Hoang LT, Hibberd ML, Tremoulet A, Varki A, Burns JC. Treatment response in kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin g. PLoS One. 2013; 8(12):e81448. PMID: 24324693.
        View in: PubMed
      34. Leuin SC, Shanbhag S, Lago D, Sato Y, Sun X, Jain S, Burns JC, Tremoulet A. Hoarseness as a presenting sign in children with kawasaki disease. Pediatr Infect Dis J. 2013 Dec; 32(12):1392-4. PMID: 23811742.
        View in: PubMed
      35. Tremoulet A. Comment on atorvastatin safety in kawasaki disease patients with coronary artery aneurysms. Pediatr Cardiol. 2014 Jan; 35(1):93. PMID: 24072043.
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      36. Burns JC, Herzog L, Fabri O, Tremoulet A, Rodó X, Uehara R, Burgner D, Bainto E, Pierce D, Tyree M, Cayan D. Seasonality of Kawasaki disease: a global perspective. PLoS One. 2013; 8(9):e74529. PMID: 24058585.
        View in: PubMed
      37. Ogata S, Tremoulet A, Sato Y, Ueda K, Shimizu C, Sun X, Jain S, Silverstein L, Baker AL, Tanaka N, Ogihara Y, Ikehara S, Takatsuki S, Sakamoto N, Kobayashi T, Fuse S, Matsubara T, Ishii M, Saji T, Newburger JW, Burns JC. Coronary artery outcomes among children with Kawasaki disease in the United States and Japan. Int J Cardiol. 2013 Oct 9; 168(4):3825-8. PMID: 23849968.
        View in: PubMed
      38. Padler-Karavani V, Tremoulet A, Yu H, Chen X, Burns JC, Varki A. A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease. PLoS One. 2013; 8(3):e58443. PMID: 23520510.
        View in: PubMed
      39. Shimizu C, Kim J, Stepanowsky P, Trinh C, Lau HD, Akers JC, Chen C, Kanegaye JT, Tremoulet A, Ohno-Machado L, Burns JC. Differential expression of miR-145 in children with Kawasaki disease. PLoS One. 2013; 8(3):e58159. PMID: 23483985.
        View in: PubMed
      40. Kanegaye JT, Van Cott E, Tremoulet A, Salgado A, Shimizu C, Kruk P, Hauschildt J, Sun X, Jain S, Burns JC. Lymph-node-first presentation of Kawasaki disease compared with bacterial cervical adenitis and typical Kawasaki disease. J Pediatr. 2013 Jun; 162(6):1259-63, 1263.e1-2. PMID: 23305955.
        View in: PubMed
      41. Jimenez-Fernandez SG, Tremoulet A. Infliximab treatment of pancreatitis complicating acute kawasaki disease. Pediatr Infect Dis J. 2012 Oct; 31(10):1087-9. PMID: 22653489.
        View in: PubMed
      42. Bratincsak A, Reddy VD, Purohit PJ, Tremoulet A, Molkara DP, Frazer JR, Dyar D, Bush RA, Sim JY, Sang N, Burns JC, Melish MA. Coronary artery dilation in acute Kawasaki disease and acute illnesses associated with Fever. Pediatr Infect Dis J. 2012 Sep; 31(9):924-6. PMID: 22673140.
        View in: PubMed
      43. Ling XB, Kanegaye JT, Ji J, Peng S, Sato Y, Tremoulet A, Burns JC, Cohen HJ. Point-of-care differentiation of Kawasaki disease from other febrile illnesses. J Pediatr. 2013 Jan; 162(1):183-188.e3. PMID: 22819274.
        View in: PubMed
      44. Broderick L, Tremoulet A, Burns JC, Hoffman HM. Prolonged urticaria and fever in a toddler. Allergy Asthma Proc. 2012 May-Jun; 33(3):297-301. PMID: 22584197.
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      45. Tremoulet A, Pancoast P, Franco A, Bujold M, Shimizu C, Onouchi Y, Tamamoto A, Erdem G, Dodd D, Burns JC. Calcineurin inhibitor treatment of intravenous immunoglobulin-resistant Kawasaki disease. J Pediatr. 2012 Sep; 161(3):506-512.e1. PMID: 22484354.
        View in: PubMed
      46. Tremoulet A, Nikanjam M, Cressey TR, Chokephaibulkit K, McKinney R, Mirochnick M, Capparelli EV. Developmental pharmacokinetic changes of Lamivudine in infants and children. J Clin Pharmacol. 2012 Dec; 52(12):1824-32. PMID: 22180560.
        View in: PubMed
      47. Tremoulet A, Jain S, Chandrasekar D, Sun X, Sato Y, Burns JC. Evolution of laboratory values in patients with Kawasaki disease. Pediatr Infect Dis J. 2011 Dec; 30(12):1022-6. PMID: 21817952.
        View in: PubMed
      48. Tremoulet A, Devera G, Best BM, Jimenez-Fernandez S, Sun X, Jain S, Burns JC. Increased incidence and severity of Kawasaki disease among Filipino-Americans in San Diego county. Pediatr Infect Dis J. 2011 Oct; 30(10):909-11. PMID: 21552184.
        View in: PubMed
      49. Sato YZ, Molkara DP, Daniels LB, Tremoulet A, Shimizu C, Kanegaye JT, Best BM, Snider JV, Frazer JR, Maisel A, Burns JC. Cardiovascular biomarkers in acute Kawasaki disease. Int J Cardiol. 2013 Mar 20; 164(1):58-63. PMID: 21777987.
        View in: PubMed
      50. Broderick L, Tremoulet A, Burns JC, Bastian JF, Hoffman HM. Recurrent fever syndromes in patients after recovery from Kawasaki syndrome. Pediatrics. 2011 Feb; 127(2):e489-93. PMID: 21220401.
        View in: PubMed
      51. Hong DK, Tremoulet A, Burns JC, Lewis DB. Cross-reactive neutralizing antibody against pandemic 2009 H1N1 influenza a virus in intravenous immunoglobulin preparations. Pediatr Infect Dis J. 2011 Jan; 30(1):67-9. PMID: 20724956.
        View in: PubMed
      52. Son MB, Gauvreau K, Burns JC, Corinaldesi E, Tremoulet A, Watson VE, Baker A, Fulton DR, Sundel RP, Newburger JW. Infliximab for intravenous immunoglobulin resistance in Kawasaki disease: a retrospective study. J Pediatr. 2011 Apr; 158(4):644-649.e1. PMID: 21129756.
        View in: PubMed
      53. Shimizu C, Jain S, Davila S, Hibberd ML, Lin KO, Molkara D, Frazer JR, Sun S, Baker AL, Newburger JW, Rowley AH, Shulman ST, Davila S, Burgner D, Breunis WB, Kuijpers TW, Wright VJ, Levin M, Eleftherohorinou H, Coin L, Popper SJ, Relman DA, Fury W, Lin C, Mellis S, Tremoulet A, Burns JC. Transforming growth factor-beta signaling pathway in patients with Kawasaki disease. Circ Cardiovasc Genet. 2011 Feb; 4(1):16-25. PMID: 21127203.
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      54. Fury W, Tremoulet A, Watson VE, Best BM, Shimizu C, Hamilton J, Kanegaye JT, Wei Y, Kao C, Mellis S, Lin C, Burns JC. Transcript abundance patterns in Kawasaki disease patients with intravenous immunoglobulin resistance. Hum Immunol. 2010 Sep; 71(9):865-73. PMID: 20600450.
        View in: PubMed
      55. Franco A, Shimizu C, Tremoulet A, Burns JC. Memory T-cells and characterization of peripheral T-cell clones in acute Kawasaki disease. Autoimmunity. 2010 Jun; 43(4):317-24. PMID: 20166878.
        View in: PubMed
      56. Kanegaye JT, Wilder MS, Molkara D, Frazer JR, Pancheri J, Tremoulet A, Watson VE, Best BM, Burns JC. Recognition of a Kawasaki disease shock syndrome. Pediatrics. 2009 May; 123(5):e783-9. PMID: 19403470.
        View in: PubMed
      57. Tremoulet A, Best BM, Song S, Wang S, Corinaldesi E, Eichenfield JR, Martin DD, Newburger JW, Burns JC. Resistance to intravenous immunoglobulin in children with Kawasaki disease. J Pediatr. 2008 Jul; 153(1):117-21. PMID: 18571548.
        View in: PubMed
      58. Tremoulet A, Capparelli EV, Patel P, Acosta EP, Luzuriaga K, Bryson Y, Wara D, Zorrilla C, Holland D, Mirochnick M. Population pharmacokinetics of lamivudine in human immunodeficiency virus-exposed and -infected infants. Antimicrob Agents Chemother. 2007 Dec; 51(12):4297-302. PMID: 17893155.
        View in: PubMed
      59. Tremoulet A, Albani S. Novel therapies for rheumatoid arthritis. Expert Opin Investig Drugs. 2006 Nov; 15(11):1427-41. PMID: 17040201.
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      60. Tremoulet A, Avila-Aguero ML, París MM, Canas-Coto A, Ulloa-Gutierrez R, Faingezicht I. Albendazole therapy for Microsporidium diarrhea in immunocompetent Costa Rican children. Pediatr Infect Dis J. 2004 Oct; 23(10):915-8. PMID: 15602190.
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