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Lucila Ohno-Machado

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0728
La Jolla CA 92093
Phone858-822-4931
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    Other Positions
    TitleDirector of BioMedical Informatics for the Clinical and Translational Research Institute


    Collapse Biography 
    Collapse Education and Training
    Stanford University, Palo Alto, CAPh.D.Medical Information Sciences and Computer Science
    University of Sao Paulo, Sao Paulo, BrazilM.D.Medicine
    Fundacao Getulio Vargas, Escola de Administração, Sao Paulo, BrazilM.B.A.Healthcare Administration
    Collapse Awards and Honors
    International Academy of Health Sciences InformaticsElected member
    American College of Medical InformaticsElected fellow
    American Society for Clinical InvestigationElected member
    American Institute for Medical and Biological EngineeringElected fellow

    Collapse Overview 
    Collapse Overview
    Professor of Medicine
    Associate Dean for Informatics and Technology, UCSD School of Medicine
    Chair, UCSD Health Department of Biomedical Informatics
    Editor in Chief, Journal of the American Medical Informatics Association
    Director, San Diego Biomedical Informatics Education and Research


    Collapse Research 
    Collapse Research Activities and Funding
    California Precision Medicine Research Program Consortium
    NIH OT2OD026552Apr 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Protecting Privacy and Facilitating Shared Access of Clinical and Genetic Data of Special Populations
    NIH/NHLBI R01HL136835Dec 15, 2017 - Nov 30, 2021
    Role: Principal Investigator
    CALIFORNIA: Cloud-agnostic Architecture to Locate Indexed FAIR Objects and safely Reuse them in New Integrated Analyses
    NIH OT3OD025462Sep 30, 2017 - Nov 30, 2018
    Role: Principal Investigator
    Decentralized differentially-private methods for dynamic data release and analysis
    NIH/NIGMS R01GM118609Jan 1, 2017 - Dec 31, 2020
    Role: Principal Investigator
    California Precision Medicine Consortium
    NIH OT2OD024611Sep 27, 2016 - Aug 31, 2017
    Role: Principal Investigator
    SERGEANT: SEcuRe GEnome Analysis competition
    NIH/NHGRI R13HG009072Sep 12, 2016 - Jun 30, 2018
    Role: Principal Investigator
    iCONCUR: informed CONsent for Clinical data and biosample Use for Research
    NIH/NHGRI R01HG008802Sep 21, 2015 - Jun 30, 2018
    Role: Principal Investigator
    BioCADDIE: Biomedical and healthCAre Data Discovery and Indexing Engine center
    NIH/NIAID U24AI117966Sep 29, 2014 - Aug 31, 2017
    Role: Principal Investigator
    San Diego Biomedical Informatics Education & Research (SABER)
    NIH/NLM T15LM011271Jul 1, 2012 - Jun 30, 2022
    Role: Principal Investigator
    Phenotype Discovery in NHLBI Genomic Studies (PhD)
    NIH/NHLBI UH3HL108785Jul 19, 2011 - Sep 23, 2014
    Role: Principal Investigator
    Phenotype Discovery in NHLBI Genomic Studies (PhD)
    NIH/NHLBI UH2HL108785Jul 19, 2011 - May 31, 2013
    Role: Principal Investigator
    SCANNER: Scalable National Network for Effectiveness Research
    AHRQ R01HS019913Sep 30, 2010 - Sep 29, 2013
    Role: Principal Investigator
    iDASH: Integrating Data for Analysis, Anonymization, and Sharing
    NIH/NHLBI U54HL108460Sep 20, 2010 - Jun 30, 2016
    Role: Principal Investigator
    Global Health Knowledge Collective: A Collaborative Toolkit for Global Health
    NIH/FIC R24TW008805Sep 15, 2010 - Aug 31, 2012
    Role: Principal Investigator
    Assessing quality of individual predictions in medical decision support systems
    NIH/NLM R01LM009520Jun 1, 2007 - Dec 2, 2011
    Role: Principal Investigator
    Biomedical Research Informatics for Global Health Training (BRIGHT) Program
    NIH/FIC D43TW007015Jun 1, 2004 - Jun 30, 2014
    Role: Principal Investigator
    CONFERENCE--GUIDELINE INTERCHANGE FORMAT (GLIF) WORKSHOP
    NIH/NLM R13LM006929Jan 3, 2000 - Aug 31, 2000
    Role: Principal Investigator
    BRAZIL/USA INTERNATIONAL TRAINING IN MEDICAL INFORMATICS
    NIH/FIC D43TW001279Sep 30, 1999 - May 31, 2004
    Role: Principal Investigator
    COMPONENT BASED TOOLS FOR CONNECTIONIST CLASSIFICATION
    NIH/NLM R01LM006538Sep 30, 1998 - Aug 31, 2001
    Role: Principal Investigator
    COMPONENT BASED TOOLS FOR CONNECTIONIST CLASSIFICATION
    NIH/NLM R29LM006538Sep 30, 1998 - Aug 31, 2000
    Role: Principal Investigator
    COMPONENT BASED TOOLS FOR CONNECTIONIST CLASSIFICATION
    NIH/NLM R55LM006538Sep 15, 1997 - Sep 29, 1998
    Role: Principal Investigator
    CONNECTIONIST MODELS OF SURVIVAL IN HIV INFECTION
    AHRQ R03HS008462Sep 1, 1994 - Feb 29, 1996
    Role: Principal Investigator
    Biomedical Informatics and Data Science Research Training Program (BIRT)
    NIH/NLM T15LM007092Jul 1, 1992 - Jun 30, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Ohno-Machado L, Kim J, Gabriel RA, Kuo GM, Hogarth MA. Genomics and electronic health record systems. Hum Mol Genet. 2018 May 01; 27(R1):R48-R55. PMID: 29741693.
      View in: PubMed
    2. Vaidya J, Shafiq B, Asani M, Adam N, Jiang X, Ohno-Machado L. A Scalable Privacy-preserving Data Generation Methodology for Exploratory Analysis. AMIA Annu Symp Proc. 2017; 2017:1695-1704. PMID: 29854240.
      View in: PubMed
    3. Nguyen NH, Ohno-Machado L, Sandborn WJ, Singh S. Infections and Cardiovascular Complications are Common Causes for Hospitalization in Older Patients with Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2018 Mar 19; 24(4):916-923. PMID: 29562273.
      View in: PubMed
    4. Nguyen NH, Khera R, Ohno-Machado L, Sandborn WJ, Singh S. Annual Burden and Costs of Hospitalization for High-Need, High-Cost Patients With Chronic Gastrointestinal and Liver Diseases. Clin Gastroenterol Hepatol. 2018 Feb 21. PMID: 29474966.
      View in: PubMed
    5. Chen F, Jiang X, Wang S, Schilling LM, Meeker D, Ong T, Matheny ME, Doctor JN, Ohno-Machado L, Vaidya J. Perfectly Secure and Efficient Two-Party Electronic-Health-Record Linkage. IEEE Internet Comput. 2018 Mar-Apr; 22(2):32-41. PMID: 29867290.
      View in: PubMed
    6. Chen X, Gururaj AE, Ozyurt B, Liu R, Soysal E, Cohen T, Tiryaki F, Li Y, Zong N, Jiang M, Rogith D, Salimi M, Kim HE, Rocca-Serra P, Gonzalez-Beltran A, Farcas C, Johnson T, Margolis R, Alter G, Sansone SA, Fore IM, Ohno-Machado L, Grethe JS, Xu H. DataMed - an open source discovery index for finding biomedical datasets. J Am Med Inform Assoc. 2018 Jan 13. PMID: 29346583.
      View in: PubMed
    7. Brennan PF, Chiang MF, Ohno-Machado L. Biomedical informatics and data science: evolving fields with significant overlap. J Am Med Inform Assoc. 2018 Jan 01; 25(1):2-3. PMID: 29267964.
      View in: PubMed
    8. Wei W, Ji Z, He Y, Zhang K, Ha Y, Li Q, Ohno-Machado L. Finding relevant biomedical datasets: the UC San Diego solution for the bioCADDIE Retrieval Challenge. Database (Oxford). 2018 Jan 01; 2018. PMID: 29688374.
      View in: PubMed
    9. Wang M, Ji Z, Wang S, Kim J, Yang H, Jiang X, Ohno-Machado L. Mechanisms to protect the privacy of families when using the transmission disequilibrium test in genome-wide association studies. Bioinformatics. 2017 Dec 01; 33(23):3716-3725. PMID: 29036461.
      View in: PubMed
    10. Dixit R, Rogith D, Narayana V, Salimi M, Gururaj A, Ohno-Machado L, Xu H, Johnson TR. User needs analysis and usability assessment of DataMed - a biomedical data discovery index. J Am Med Inform Assoc. 2017 Nov 30. PMID: 29202203.
      View in: PubMed
    11. Ohno-Machado L. JAMIA is going green. J Am Med Inform Assoc. 2017 Nov 01; 24(6):1045. PMID: 29016975.
      View in: PubMed
    12. Kuo TT, Kim HE, Ohno-Machado L. Blockchain distributed ledger technologies for biomedical and health care applications. J Am Med Inform Assoc. 2017 Nov 01; 24(6):1211-1220. PMID: 29016974.
      View in: PubMed
    13. Wang S, Jiang X, Tang H, Wang X, Bu D, Carey K, Dyke SO, Fox D, Jiang C, Lauter K, Malin B, Sofia H, Telenti A, Wang L, Wang W, Ohno-Machado L. A community effort to protect genomic data sharing, collaboration and outsourcing. NPJ Genom Med. 2017; 2:33. PMID: 29263842.
      View in: PubMed
    14. Raisaro JL, Tramèr F, Ji Z, Bu D, Zhao Y, Carey K, Lloyd D, Sofia H, Baker D, Flicek P, Shringarpure S, Bustamante C, Wang S, Jiang X, Ohno-Machado L, Tang H, Wang X, Hubaux JP. Addressing Beacon re-identification attacks: quantification and mitigation of privacy risks. J Am Med Inform Assoc. 2017 Jul 01; 24(4):799-805. PMID: 28339683.
      View in: PubMed
    15. Ohno-Machado L. Education of informatics professionals and development of electronic information resources for clinicians, patients, health scientists, and study participants. J Am Med Inform Assoc. 2017 Jul 01; 24(4):679. PMID: 28927160.
      View in: PubMed
    16. Sansone SA, Gonzalez-Beltran A, Rocca-Serra P, Alter G, Grethe JS, Xu H, Fore IM, Lyle J, Gururaj AE, Chen X, Kim HE, Zong N, Li Y, Liu R, Ozyurt IB, Ohno-Machado L. DATS, the data tag suite to enable discoverability of datasets. Sci Data. 2017 06 06; 4:170059. PMID: 28585923.
      View in: PubMed
    17. Ohno-Machado L, Sansone SA, Alter G, Fore I, Grethe J, Xu H, Gonzalez-Beltran A, Rocca-Serra P, Gururaj AE, Bell E, Soysal E, Zong N, Kim HE. Finding useful data across multiple biomedical data repositories using DataMed. Nat Genet. 2017 May 26; 49(6):816-819. PMID: 28546571.
      View in: PubMed
    18. Jagodnik KM, Koplev S, Jenkins SL, Ohno-Machado L, Paten B, Schurer SC, Dumontier M, Verborgh R, Bui A, Ping P, McKenna NJ, Madduri R, Pillai A, Ma'ayan A. Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop. J Biomed Inform. 2017 07; 71:49-57. PMID: 28501646.
      View in: PubMed
    19. Gabriel RA, Waterman RS, Kim J, Ohno-Machado L. A Predictive Model for Extended Postanesthesia Care Unit Length of Stay in Outpatient Surgeries. Anesth Analg. 2017 05; 124(5):1529-1536. PMID: 28079580.
      View in: PubMed
    20. Ohno-Machado L. Advancing healthcare and biomedical research via new data-driven approaches. J Am Med Inform Assoc. 2017 May 01; 24(3):471. PMID: 28403381.
      View in: PubMed
    21. Malhotra R, Kashani KB, Macedo E, Kim J, Bouchard J, Wynn S, Li G, Ohno-Machado L, Mehta R. A risk prediction score for acute kidney injury in the intensive care unit. Nephrol Dial Transplant. 2017 May 01; 32(5):814-822. PMID: 28402551.
      View in: PubMed
    22. Ohno-Machado L. Electronic health records: usability and utilization by health care providers and patients. J Am Med Inform Assoc. 2017 Apr 01; 24(e1):e1. PMID: 28395061.
      View in: PubMed
    23. Chen F, Wang S, Jiang X, Ding S, Lu Y, Kim J, Sahinalp SC, Shimizu C, Burns JC, Wright VJ, Png E, Hibberd ML, Lloyd DD, Yang H, Telenti A, Bloss CS, Fox D, Lauter K, Ohno-Machado L. PRINCESS: Privacy-protecting Rare disease International Network Collaboration via Encryption through Software guard extensionS. Bioinformatics. 2017 03 15; 33(6):871-878. PMID: 28065902.
      View in: PubMed
    24. Ohno-Machado L. Health information technology and patient safety. J Am Med Inform Assoc. 2017 03 01; 24(2):243. PMID: 28204518.
      View in: PubMed
    25. Kim H, Bell E, Kim J, Sitapati A, Ramsdell J, Farcas C, Friedman D, Feupe SF, Ohno-Machado L. iCONCUR: informed consent for clinical data and bio-sample use for research. J Am Med Inform Assoc. 2017 03 01; 24(2):380-387. PMID: 27589942.
      View in: PubMed
    26. Sitapati A, Kim H, Berkovich B, Marmor R, Singh S, El-Kareh R, Clay B, Ohno-Machado L. Integrated precision medicine: the role of electronic health records in delivering personalized treatment. Wiley Interdiscip Rev Syst Biol Med. 2017 05; 9(3). PMID: 28207198.
      View in: PubMed
    27. Kim H, Choi J, Jang I, Quach J, Ohno-Machado L. Feasibility of Representing Data from Published Nursing Research Using the OMOP Common Data Model. AMIA Annu Symp Proc. 2016; 2016:715-723. PMID: 28269868.
      View in: PubMed
    28. Kuo TT, Rao P, Maehara C, Doan S, Chaparro JD, Day ME, Farcas C, Ohno-Machado L, Hsu CN. Ensembles of NLP Tools for Data Element Extraction from Clinical Notes. AMIA Annu Symp Proc. 2016; 2016:1880-1889. PMID: 28269947.
      View in: PubMed
    29. Kim J, Shimizu C, Kingsmore SF, Veeraraghavan N, Levy E, Ribeiro Dos Santos AM, Yang H, Flatley J, Hoang LT, Hibberd ML, Tremoulet AH, Harismendy O, Ohno-Machado L, Burns JC. Whole genome sequencing of an African American family highlights toll like receptor 6 variants in Kawasaki disease susceptibility. PLoS One. 2017; 12(2):e0170977. PMID: 28151979.
      View in: PubMed
    30. Suominen H, Müller H, Ohno-Machado L, Salanterä S, Schreier G, Hanlen L. Prerequisites for International Exchanges of Health Information for Record Research: Comparison of Australian, Austrian, Finnish, Swiss, and US Policies. Stud Health Technol Inform. 2017; 245:1312. PMID: 29295395.
      View in: PubMed
    31. Hinske LC, Dos Santos FRC, Ohara DT, Ohno-Machado L, Kreth S, Galante PAF. MiRIAD update: using alternative polyadenylation, protein interaction network analysis and additional species to enhance exploration of the role of intragenic miRNAs and their host genes. Database (Oxford). 2017 Jan 01; 2017. PMID: 29220447.
      View in: PubMed
    32. Cohen T, Roberts K, Gururaj AE, Chen X, Pournejati S, Alter G, Hersh WR, Demner-Fushman D, Ohno-Machado L, Xu H. A publicly available benchmark for biomedical dataset retrieval: the reference standard for the 2016 bioCADDIE dataset retrieval challenge. Database (Oxford). 2017 Jan 01; 2017. PMID: 29220453.
      View in: PubMed
    33. Ohno-Machado L. Using health information technology for clinical decision support and predictive analytics. J Am Med Inform Assoc. 2017 Jan; 24(1):1. PMID: 28039394.
      View in: PubMed
    34. Eguchi A, Lazaro RG, Wang J, Kim J, Povero D, Willliams B, Ho SB, Stärkel P, Schnabl B, Ohno-Machado L, Tsukamoto H, Feldstein AE. Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology. 2017 02; 65(2):475-490. PMID: 27639178.
      View in: PubMed
    35. Ohno-Machado L. Data-driven informatics tools targeting patients and providers. J Am Med Inform Assoc. 2016 Nov; 23(6):1039. PMID: 27880716.
      View in: PubMed
    36. Tang H, Jiang X, Wang X, Wang S, Sofia H, Fox D, Lauter K, Malin B, Telenti A, Xiong L, Ohno-Machado L. Protecting genomic data analytics in the cloud: state of the art and opportunities. BMC Med Genomics. 2016 10 13; 9(1):63. PMID: 27733153.
      View in: PubMed
    37. Wang S, Jiang X, Singh S, Marmor R, Bonomi L, Fox D, Dow M, Ohno-Machado L. Genome privacy: challenges, technical approaches to mitigate risk, and ethical considerations in the United States. Ann N Y Acad Sci. 2017 01; 1387(1):73-83. PMID: 27681358.
      View in: PubMed
    38. Nodora JN, Komenaka IK, Bouton ME, Ohno-Machado L, Schwab R, Kim HE, Farcas C, Perez G, Elena Martinez M. Biospecimen Sharing Among Hispanic Women in a Safety-Net Clinic: Implications for the Precision Medicine Initiative. J Natl Cancer Inst. 2017 02; 109(2). PMID: 27688295.
      View in: PubMed
    39. Ohno-Machado L. Building systems that change clinical practice and advance health sciences research. J Am Med Inform Assoc. 2016 Sep; 23(5):857. PMID: 27562746.
      View in: PubMed
    40. Shi H, Jiang C, Dai W, Jiang X, Tang Y, Ohno-Machado L, Wang S. Secure Multi-pArty Computation Grid LOgistic REgression (SMAC-GLORE). BMC Med Inform Decis Mak. 2016 07 25; 16 Suppl 3:89. PMID: 27454168; PMCID: PMC4959358.
    41. Wei W, Marmor R, Singh S, Wang S, Demner-Fushman D, Kuo TT, Hsu CN, Ohno-Machado L. Finding Related Publications: Extending the Set of Terms Used to Assess Article Similarity. AMIA Jt Summits Transl Sci Proc. 2016; 2016:225-34. PMID: 27570676; PMCID: PMC5001748.
    42. Doan S, Maehara CK, Chaparro JD, Lu S, Liu R, Graham A, Berry E, Hsu CN, Kanegaye JT, Lloyd DD, Ohno-Machado L, Burns JC, Tremoulet AH. Building a Natural Language Processing Tool to Identify Patients With High Clinical Suspicion for Kawasaki Disease from Emergency Department Notes. Acad Emerg Med. 2016 05; 23(5):628-36. PMID: 26826020.
      View in: PubMed
    43. Ohno-Machado L. Data and the clinical decision support loop. J Am Med Inform Assoc. 2016 Apr; 23(e1):e1. PMID: 27071919; PMCID: PMC4954618 [Available on 04/01/17].
    44. Amarasingham R, Audet AM, Bates DW, Glenn Cohen I, Entwistle M, Escobar GJ, Liu V, Etheredge L, Lo B, Ohno-Machado L, Ram S, Saria S, Schilling LM, Shahi A, Stewart WF, Steyerberg EW, Xie B. Consensus Statement on Electronic Health Predictive Analytics: A Guiding Framework to Address Challenges. EGEMS (Wash DC). 2016; 4(1):1163. PMID: 27141516; PMCID: PMC4837887.
    45. Ohno-Machado L. A message to the next generation of biomedical informatics professionals. J Am Med Inform Assoc. 2016 Mar; 23(2):241. PMID: 26961493.
      View in: PubMed
    46. Ohno-Machado L. Using informatics to engage patients and healthcare providers. J Am Med Inform Assoc. 2016 Jan; 23(1):1. PMID: 26912536.
      View in: PubMed
    47. Kroll JE, Kim J, Ohno-Machado L, de Souza SJ. Splicing Express: a software suite for alternative splicing analysis using next-generation sequencing data. PeerJ. 2015; 3:e1419. PMID: 26618088; PMCID: PMC4655094.
    48. Li Y, Jiang X, Wang S, Xiong H, Ohno-Machado L. VERTIcal Grid lOgistic regression (VERTIGO). J Am Med Inform Assoc. 2016 May; 23(3):570-9. PMID: 26554428; PMCID: PMC4901373 [Available on 05/01/17].
    49. Han D, Wang S, Jiang C, Jiang X, Kim HE, Sun J, Ohno-Machado L. Trends in biomedical informatics: automated topic analysis of JAMIA articles. J Am Med Inform Assoc. 2015 Nov; 22(6):1153-63. PMID: 26555018; PMCID: PMC5009912 [Available on 11/01/16].
    50. Calvo RY, Lindsay SP, Edland SD, Macera CA, Wingard DL, Ohno-Machado L, Sise MJ. The differential associations of preexisting conditions with trauma-related outcomes in the presence of competing risks. Injury. 2016 Mar; 47(3):677-84. PMID: 26684173.
      View in: PubMed
    51. Ohno-Machado L. Mining electronic health record data: finding the gold nuggets. J Am Med Inform Assoc. 2015 Sep; 22(5):937. PMID: 26330468.
      View in: PubMed
    52. Lu CL, Wang S, Ji Z, Wu Y, Xiong L, Jiang X, Ohno-Machado L. WebDISCO: a web service for distributed cox model learning without patient-level data sharing. J Am Med Inform Assoc. 2015 Nov; 22(6):1212-9. PMID: 26159465; PMCID: PMC5009917 [Available on 11/01/16].
    53. Meeker D, Jiang X, Matheny ME, Farcas C, D'Arcy M, Pearlman L, Nookala L, Day ME, Kim KK, Kim H, Boxwala A, El-Kareh R, Kuo GM, Resnic FS, Kesselman C, Ohno-Machado L. A system to build distributed multivariate models and manage disparate data sharing policies: implementation in the scalable national network for effectiveness research. J Am Med Inform Assoc. 2015 Nov; 22(6):1187-95. PMID: 26142423; PMCID: PMC4639714 [Available on 11/01/16].
    54. Ohno-Machado L. Tailoring informatics interventions to patients and healthcare providers. J Am Med Inform Assoc. 2015 Jul; 22(4):747. PMID: 26116707.
      View in: PubMed
    55. Ohno-Machado L. A journal's role in resource sharing and reproducibility. J Am Med Inform Assoc. 2015 May; 22(3):491. PMID: 26048962.
      View in: PubMed
    56. Kim KK, Joseph JG, Ohno-Machado L. Comparison of consumers' views on electronic data sharing for healthcare and research. J Am Med Inform Assoc. 2015 Jul; 22(4):821-30. PMID: 25829461; PMCID: PMC5009901.
    57. Wei W, Demner-Fushman D, Wang S, Jiang X, Ohno-Machado L. Ranking Medical Subject Headings using a factor graph model. AMIA Jt Summits Transl Sci Proc. 2015; 2015:56-63. PMID: 26306236; PMCID: PMC4525219.
    58. Hinske LC, Galante PA, Limbeck E, Möhnle P, Parmigiani RB, Ohno-Machado L, Camargo AA, Kreth S. Alternative polyadenylation allows differential negative feedback of human miRNA miR-579 on its host gene ZFR. PLoS One. 2015; 10(3):e0121507. PMID: 25799583; PMCID: PMC4370670.
    59. Wu Y, Jiang X, Wang S, Jiang W, Li P, Ohno-Machado L. Grid multi-category response logistic models. BMC Med Inform Decis Mak. 2015 Feb 18; 15:10. PMID: 25886151; PMCID: PMC4342889.
    60. Jiang X, Wu Y, Marsolo K, Ohno-Machado L. Development of a web service for analysis in a distributed network. EGEMS (Wash DC). 2014; 2(1):1053. PMID: 25848586; PMCID: PMC4371401.
    61. Jiang X, Zhao Y, Wang X, Malin B, Wang S, Ohno-Machado L, Tang H. A community assessment of privacy preserving techniques for human genomes. BMC Med Inform Decis Mak. 2014; 14 Suppl 1:S1. PMID: 25521230; PMCID: PMC4290799.
    62. Bell EA, Ohno-Machado L, Grando MA. Sharing my health data: a survey of data sharing preferences of healthy individuals. AMIA Annu Symp Proc. 2014; 2014:1699-708. PMID: 25954442; PMCID: PMC4419941.
    63. Kim H, Ohno-Machado L, Oh J, Jiang X. Trends in publication of nursing informatics research. AMIA Annu Symp Proc. 2014; 2014:805-14. PMID: 25954387; PMCID: PMC4419947.
    64. Ohno-Machado L. Disseminating informatics knowledge and training the next generation of leaders. J Am Med Inform Assoc. 2014 Nov-Dec; 21(6):954-6. PMID: 25301807; PMCID: PMC4215064.
    65. Ohno-Machado L. Focusing on the patient: mHealth, social media, electronic health records, and decision support systems. J Am Med Inform Assoc. 2014 Nov-Dec; 21(6):953. PMID: 25301806; PMCID: PMC4215063.
    66. Zhao Y, Wang X, Jiang X, Ohno-Machado L, Tang H. Choosing blindly but wisely: differentially private solicitation of DNA datasets for disease marker discovery. J Am Med Inform Assoc. 2015 Jan; 22(1):100-8. PMID: 25352565; PMCID: PMC4433380.
    67. Stepanowsky P, Levy E, Kim J, Jiang X, Ohno-Machado L. Prediction of MicroRNA Precursors Using Parsimonious Feature Sets. Cancer Inform. 2014; 13(Suppl 1):95-102. PMID: 25392687; PMCID: PMC4216048.
    68. Hinske LC, França GS, Torres HA, Ohara DT, Lopes-Ramos CM, Heyn J, Reis LF, Ohno-Machado L, Kreth S, Galante PA. miRIAD-integrating microRNA inter- and intragenic data. Database (Oxford). 2014; 2014. PMID: 25288656; PMCID: PMC4186326.
    69. Ohno-Machado L. Structuring text and standardizing data for clinical and population health applications. J Am Med Inform Assoc. 2014 Sep-Oct; 21(5):763. PMID: 25117592; PMCID: PMC4147604.
    70. Ross MK, Wei W, Ohno-Machado L. "Big data" and the electronic health record. Yearb Med Inform. 2014 Aug 15; 9:97-104. PMID: 25123728; PMCID: PMC4287068.
    71. Ohno-Machado L. Networking the country to promote health and scientific discovery. J Am Med Inform Assoc. 2014 Jul-Aug; 21(4):575. PMID: 24908676; PMCID: PMC4078300.
    72. Bates DW, Saria S, Ohno-Machado L, Shah A, Escobar G. Big data in health care: using analytics to identify and manage high-risk and high-cost patients. Health Aff (Millwood). 2014 Jul; 33(7):1123-31. PMID: 25006137.
      View in: PubMed
    73. Li H, Xiong L, Ohno-Machado L, Jiang X. Privacy preserving RBF kernel support vector machine. Biomed Res Int. 2014; 2014:827371. PMID: 25013805; PMCID: PMC4071990.
    74. Kim J, Levy E, Ferbrache A, Stepanowsky P, Farcas C, Wang S, Brunner S, Bath T, Wu Y, Ohno-Machado L. MAGI: a Node.js web service for fast microRNA-Seq analysis in a GPU infrastructure. Bioinformatics. 2014 Oct; 30(19):2826-7. PMID: 24907367; PMCID: PMC4173015.
    75. Wang S, Kim J, Jiang X, Brunner SF, Ohno-Machado L. GAMUT: GPU accelerated microRNA analysis to uncover target genes through CUDA-miRanda. BMC Med Genomics. 2014; 7 Suppl 1:S9. PMID: 25077821; PMCID: PMC4101446.
    76. Ji Z, Jiang X, Wang S, Xiong L, Ohno-Machado L. Differentially private distributed logistic regression using private and public data. BMC Med Genomics. 2014; 7 Suppl 1:S14. PMID: 25079786; PMCID: PMC4101668.
    77. Ohno-Machado L, Agha Z, Bell DS, Dahm L, Day ME, Doctor JN, Gabriel D, Kahlon MK, Kim KK, Hogarth M, Matheny ME, Meeker D, Nebeker JR. pSCANNER: patient-centered Scalable National Network for Effectiveness Research. J Am Med Inform Assoc. 2014 Jul-Aug; 21(4):621-6. PMID: 24780722; PMCID: PMC4078293.
    78. Menon AK, Jiang X, Kim J, Vaidya J, Ohno-Machado L. Detecting Inappropriate Access to Electronic Health Records Using Collaborative Filtering. Mach Learn. 2014 Apr 01; 95(1):87-101. PMID: 24683293.
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    79. Ohno-Machado L. NIH's Big Data to Knowledge initiative and the advancement of biomedical informatics. J Am Med Inform Assoc. 2014 Mar-Apr; 21(2):193. PMID: 24509598; PMCID: PMC3932475.
    80. Ohno-Machado L. Electronic health record systems: risks and benefits. J Am Med Inform Assoc. 2014 Feb; 21(e1):e1. PMID: 24453123; PMCID: PMC3957407.
    81. Ohno-Machado L. The role of scientific publication in times of change. J Am Med Inform Assoc. 2014 Jan-Feb; 21(1):1. PMID: 24335250; PMCID: PMC3912704.
    82. Doan S, Conway M, Phuong TM, Ohno-Machado L. Natural language processing in biomedicine: a unified system architecture overview. Methods Mol Biol. 2014; 1168:275-94. PMID: 24870142.
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    83. Li P, Jiang X, Wang S, Kim J, Xiong H, Ohno-Machado L. HUGO: Hierarchical mUlti-reference Genome cOmpression for aligned reads. J Am Med Inform Assoc. 2014 Mar-Apr; 21(2):363-73. PMID: 24368726; PMCID: PMC3932469.
    84. Kim KK, Browe DK, Logan HC, Holm R, Hack L, Ohno-Machado L. Data governance requirements for distributed clinical research networks: triangulating perspectives of diverse stakeholders. J Am Med Inform Assoc. 2014 Jul-Aug; 21(4):714-9. PMID: 24302285; PMCID: PMC4078279.
    85. Ohno-Machado L. Game changer: how informatics moved from a supporting role to a central position in healthcare. J Am Med Inform Assoc. 2013 Dec; 20(e2):e197. PMID: 24302668; PMCID: PMC3861937.
    86. Li P, Wang S, Kim J, Xiong H, Ohno-Machado L, Jiang X. DNA-COMPACT: DNA COMpression based on a pattern-aware contextual modeling technique. PLoS One. 2013; 8(11):e80377. PMID: 24282536; PMCID: PMC3840021.
    87. Jiang X, Tse K, Wang S, Doan S, Kim H, Ohno-Machado L. Recent trends in biomedical informatics: a study based on JAMIA articles. J Am Med Inform Assoc. 2013 Dec; 20(e2):e198-205. PMID: 24214018; PMCID: PMC3861936.
    88. Ohno-Machado L. Data science and informatics: when it comes to biomedical data, is there a real distinction? J Am Med Inform Assoc. 2013 Nov-Dec; 20(6):1009. PMID: 24114329; PMCID: PMC3822125.
    89. Jiang W, Li P, Wang S, Wu Y, Xue M, Ohno-Machado L, Jiang X. WebGLORE: a web service for Grid LOgistic REgression. Bioinformatics. 2013 Dec 15; 29(24):3238-40. PMID: 24072732; PMCID: PMC3842761.
    90. Ohno-Machado L, Nadkarni P, Johnson K. Natural language processing: algorithms and tools to extract computable information from EHRs and from the biomedical literature. J Am Med Inform Assoc. 2013 Sep-Oct; 20(5):805. PMID: 23935077; PMCID: PMC3756279.
    91. Doan S, Lin KW, Conway M, Ohno-Machado L, Hsieh A, Feupe SF, Garland A, Ross MK, Jiang X, Farzaneh S, Walker R, Alipanah N, Zhang J, Xu H, Kim HE. PhenDisco: phenotype discovery system for the database of genotypes and phenotypes. J Am Med Inform Assoc. 2014 Jan-Feb; 21(1):31-6. PMID: 23989082; PMCID: PMC3912702.
    92. Jiang X, Sarwate AD, Ohno-Machado L. Privacy technology to support data sharing for comparative effectiveness research: a systematic review. Med Care. 2013 Aug; 51(8 Suppl 3):S58-65. PMID: 23774511; PMCID: PMC3728160.
    93. Kim KK, McGraw D, Mamo L, Ohno-Machado L. Development of a privacy and security policy framework for a multistate comparative effectiveness research network. Med Care. 2013 Aug; 51(8 Suppl 3):S66-72. PMID: 23774516.
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    94. Butte AJ, Ohno-Machado L. Making it personal: translational bioinformatics. J Am Med Inform Assoc. 2013 Jul-Aug; 20(4):595-6. PMID: 23757438; PMCID: PMC3721179.
    95. Ohno-Machado L. Electronic health records: monitoring the return on large investments. J Am Med Inform Assoc. 2013 Jun; 20(e1):e1. PMID: 23687172; PMCID: PMC3715341.
    96. Wang S, Jiang X, Wu Y, Cui L, Cheng S, Ohno-Machado L. EXpectation Propagation LOgistic REgRession (EXPLORER): distributed privacy-preserving online model learning. J Biomed Inform. 2013 Jun; 46(3):480-96. PMID: 23562651; PMCID: PMC3676314.
    97. Jiang X, Ji Z, Wang S, Mohammed N, Cheng S, Ohno-Machado L. Differential-Private Data Publishing Through Component Analysis. Trans Data Priv. 2013 Apr; 6(1):19-34. PMID: 24409205.
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    98. Dai W, Xiong H, Jiang X, Ohno-Machado L. An Adaptive Difference Distribution-based Coding with Hierarchical Tree Structure for DNA Sequence Compression. Proc Data Compress Conf. 2013; 2013:371-380. PMID: 26501129.
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    99. Ohno-Machado L, Farcas C, Kim J, Wang S, Jiang X. Genomes in the cloud: balancing privacy rights and the public good. AMIA Jt Summits Transl Sci Proc. 2013; 2013:128. PMID: 24303320.
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    100. Vaidya J, Shafiq B, Jiang X, Ohno-Machado L. Identifying inference attacks against healthcare data repositories. AMIA Jt Summits Transl Sci Proc. 2013; 2013:262-6. PMID: 24303279; PMCID: PMC3845790.
    101. Shimizu C, Kim J, Stepanowsky P, Trinh C, Lau HD, Akers JC, Chen C, Kanegaye JT, Tremoulet A, Ohno-Machado L, Burns JC. Differential expression of miR-145 in children with Kawasaki disease. PLoS One. 2013; 8(3):e58159. PMID: 23483985; PMCID: PMC3590129.
    102. Ohno-Machado L. Informatics that works for you. J Am Med Inform Assoc. 2013 Mar-Apr; 20(2):211. PMID: 23400397; PMCID: PMC3638197.
    103. Thawait SK, Kim J, Klufas RA, Morrison WB, Flanders AE, Carrino JA, Ohno-Machado L. Comparison of four prediction models to discriminate benign from malignant vertebral compression fractures according to MRI feature analysis. AJR Am J Roentgenol. 2013 Mar; 200(3):493-502. PMID: 23436836.
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    104. Bafna V, Kozanitis C, Deutsch A, Ohno-Machado L, Heiberg A, Varghese G. Abstractions for Genomics. Commun ACM. 2013 Jan; 56(1):83-93. PMID: 25284821.
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    105. Ohno-Machado L. Sharing data for the public good and protecting individual privacy: informatics solutions to combine different goals. J Am Med Inform Assoc. 2013 Jan 01; 20(1):1. PMID: 23243087; PMCID: PMC3555342.
    106. Roozgard A, Barzigar N, Wang S, Jiang X, Ohno-Machado L, Cheng S. Nucleotide sequence alignment using sparse coding and belief propagation. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:588-91. PMID: 24109755; PMCID: PMC3909563.
    107. Hinske LC, Heyn J, Galante PA, Ohno-Machado L, Kreth S. Setting up an intronic miRNA database. Methods Mol Biol. 2013; 936:69-76. PMID: 23007499.
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    108. de Souza JE, Galante PA, de Almeida RV, da Cunha JP, Ohara DT, Ohno-Machado L, Old LJ, de Souza SJ. SurfaceomeDB: a cancer-orientated database for genes encoding cell surface proteins. Cancer Immun. 2012; 12:15. PMID: 23390370; PMCID: PMC3554024.
    109. Ohno-Machado L. To share or not to share: that is not the question. Sci Transl Med. 2012 Dec 19; 4(165):165cm15. PMID: 23253606.
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    110. Mohammed N, Jiang X, Chen R, Fung BC, Ohno-Machado L. Privacy-preserving heterogeneous health data sharing. J Am Med Inform Assoc. 2013 May 01; 20(3):462-9. PMID: 23242630; PMCID: PMC3628047.
    111. Jiang X, Menon A, Wang S, Kim J, Ohno-Machado L. Doubly Optimized Calibrated Support Vector Machine (DOC-SVM): an algorithm for joint optimization of discrimination and calibration. PLoS One. 2012; 7(11):e48823. PMID: 23139819; PMCID: PMC3490990.
    112. Jiang X, Kim J, Wu Y, Wang S, Ohno-Machado L. Selecting cases for whom additional tests can improve prognostication. AMIA Annu Symp Proc. 2012; 2012:1260-8. PMID: 23304404; PMCID: PMC3540468.
    113. Wu Y, Jiang X, Ohno-Machado L. Preserving Institutional Privacy in Distributed binary Logistic Regression. AMIA Annu Symp Proc. 2012; 2012:1450-8. PMID: 23304425; PMCID: PMC3540539.
    114. Que J, Jiang X, Ohno-Machado L. A collaborative framework for Distributed Privacy-Preserving Support Vector Machine learning. AMIA Annu Symp Proc. 2012; 2012:1350-9. PMID: 23304414; PMCID: PMC3540462.
    115. Ohno-Machado L. Careers in informatics: a diversity of options with an abundance of jobs. J Am Med Inform Assoc. 2012 Nov-Dec; 19(6):919. PMID: 23077280; PMCID: PMC3534476.
    116. Kroll JE, Galante PA, Ohara DT, Navarro FC, Ohno-Machado L, de Souza SJ. SPLOOCE: a new portal for the analysis of human splicing variants. RNA Biol. 2012 Nov; 9(11):1339-43. PMID: 23064119; PMCID: PMC3597574.
    117. Gardner J, Xiong L, Xiao Y, Gao J, Post AR, Jiang X, Ohno-Machado L. SHARE: system design and case studies for statistical health information release. J Am Med Inform Assoc. 2013 Jan 01; 20(1):109-16. PMID: 23059729; PMCID: PMC3555328.
    118. Ohno-Machado L. Informatics 2.0: implications of social media, mobile health, and patient-reported outcomes for healthcare and individual privacy. J Am Med Inform Assoc. 2012 Sep-Oct; 19(5):683. PMID: 22879365; PMCID: PMC3422848.
    119. von Muhlen M, Ohno-Machado L. Reviewing social media use by clinicians. J Am Med Inform Assoc. 2012 Sep-Oct; 19(5):777-81. PMID: 22759618; PMCID: PMC3422846.
    120. Berger T, Meng E, George S, Khoo M, Marmarelis V, McCulloch A, Cauwenberghs G, Ohno-Machado L, Schultz J, Johnson JP. Southern California: a hotbed of biomedical engineering: nine bioengineers describe their research and why Southern California has the biotech market cornered. IEEE Pulse. 2012 Jul; 3(4):14-21. PMID: 23008840.
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    121. Kim H, Tamayo D, Muhkin M, Kim J, Lam J, Ohno-Machado L, Aronoff-Spencer E. Pictogram evaluation and authoring collaboration environment. NI 2012 (2012). 2012; 2012:214. PMID: 24199088; PMCID: PMC3799134.
    122. Ohno-Machado L. Big science, big data, and a big role for biomedical informatics. J Am Med Inform Assoc. 2012 Jun; 19(e1):e1. PMID: 22718034; PMCID: PMC3392845.
    123. Sarin P, Urman RD, Ohno-Machado L. An improved model for predicting postoperative nausea and vomiting in ambulatory surgery patients using physician-modifiable risk factors. J Am Med Inform Assoc. 2012 Nov-Dec; 19(6):995-1002. PMID: 22582204; PMCID: PMC3534465.
    124. Wu Y, Jiang X, Kim J, Ohno-Machado L. Grid Binary LOgistic REgression (GLORE): building shared models without sharing data. J Am Med Inform Assoc. 2012 Sep-Oct; 19(5):758-64. PMID: 22511014; PMCID: PMC3422844.
    125. Jiang X, Boxwala AA, El-Kareh R, Kim J, Ohno-Machado L. A patient-driven adaptive prediction technique to improve personalized risk estimation for clinical decision support. J Am Med Inform Assoc. 2012 Jun; 19(e1):e137-44. PMID: 22493049; PMCID: PMC3392846.
    126. Wu Y, Jiang X, Kim J, Ohno-Machado L. I-spline Smoothing for Calibrating Predictive Models. AMIA Jt Summits Transl Sci Proc. 2012; 2012:39-46. PMID: 22779048; PMCID: PMC3392066.
    127. Ohno-Machado L. Informatics research to enable clinically relevant, personalized genomic medicine. J Am Med Inform Assoc. 2012 Mar-Apr; 19(2):149-50. PMID: 22319175; PMCID: PMC3277638.
    128. Menon AK, Jiang XJ, Vembu S, Elkan C, Ohno-Machado L. Predicting accurate probabilities with a ranking loss. Proc Int Conf Mach Learn. 2012; 2012:703-710. PMID: 25285328.
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    129. Ohno-Machado L. Computer-based safety surveillance and patient-centered health records. J Am Med Inform Assoc. 2012 Jan-Feb; 19(1):1. PMID: 22155973; PMCID: PMC3240770.
    130. Trachtenberg AJ, Robert JH, Abdalla AE, Fraser A, He SY, Lacy JN, Rivas-Morello C, Truong A, Hardiman G, Ohno-Machado L, Liu F, Hovig E, Kuo WP. A primer on the current state of microarray technologies. Methods Mol Biol. 2012; 802:3-17. PMID: 22130870.
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    131. Ohno-Machado L. Innovative approaches to support patient decision making, improve safety, and enable large-scale clinical research. J Am Med Inform Assoc. 2011 Dec; 18 Suppl 1:i1. PMID: 22180872; PMCID: PMC3241183.
    132. Kim HE, Jiang X, Kim J, Ohno-Machado L. Trends in biomedical informatics: most cited topics from recent years. J Am Med Inform Assoc. 2011 Dec; 18 Suppl 1:i166-70. PMID: 22180873; PMCID: PMC3241182.
    133. Ohno-Machado L, Bafna V, Boxwala AA, Chapman BE, Chapman WW, Chaudhuri K, Day ME, Farcas C, Heintzman ND, Jiang X, Kim H, Kim J, Matheny ME, Resnic FS, Vinterbo SA. iDASH: integrating data for analysis, anonymization, and sharing. J Am Med Inform Assoc. 2012 Mar-Apr; 19(2):196-201. PMID: 22081224; PMCID: PMC3277627.
    134. Jiang X, El-Kareh R, Ohno-Machado L. Improving predictions in imbalanced data using Pairwise Expanded Logistic Regression. AMIA Annu Symp Proc. 2011; 2011:625-34. PMID: 22195118; PMCID: PMC3243279.
    135. Kim J, Grillo JM, Boxwala AA, Jiang X, Mandelbaum RB, Patel BA, Mikels D, Vinterbo SA, Ohno-Machado L. Anomaly and signature filtering improve classifier performance for detection of suspicious access to EHRs. AMIA Annu Symp Proc. 2011; 2011:723-31. PMID: 22195129; PMCID: PMC3243249.
    136. Jiang X, Osl M, Kim J, Ohno-Machado L. Calibrating predictive model estimates to support personalized medicine. J Am Med Inform Assoc. 2012 Mar-Apr; 19(2):263-74. PMID: 21984587; PMCID: PMC3277613.
    137. Ohno-Machado L. Realizing the full potential of electronic health records: the role of natural language processing. J Am Med Inform Assoc. 2011 Sep-Oct; 18(5):539. PMID: 21846784; PMCID: PMC3168331.
    138. Nadkarni PM, Ohno-Machado L, Chapman WW. Natural language processing: an introduction. J Am Med Inform Assoc. 2011 Sep-Oct; 18(5):544-51. PMID: 21846786; PMCID: PMC3168328.
    139. Ohno-Machado L. Biomedical informatics: how we got here and where we are headed. J Am Med Inform Assoc. 2011 Jul-Aug; 18(4):351. PMID: 21672903; PMCID: PMC3128422.
    140. Boxwala AA, Kim J, Grillo JM, Ohno-Machado L. Using statistical and machine learning to help institutions detect suspicious access to electronic health records. J Am Med Inform Assoc. 2011 Jul-Aug; 18(4):498-505. PMID: 21672912; PMCID: PMC3128412.
    141. Sarkar IN, Butte AJ, Lussier YA, Tarczy-Hornoch P, Ohno-Machado L. Translational bioinformatics: linking knowledge across biological and clinical realms. J Am Med Inform Assoc. 2011 Jul-Aug; 18(4):354-7. PMID: 21561873; PMCID: PMC3128415.
    142. Ohno-Machado L. Informatics is about algorithms, systems, people, and social networks. J Am Med Inform Assoc. 2011 May 01; 18(3):209. PMID: 21486878; PMCID: PMC3078672.
    143. Ohno-Machado L. A hybrid open-access model to bridge the publishing divide and reach out to a broader community. J Am Med Inform Assoc. 2011 May 01; 18(3):210-1. PMID: 21486879; PMCID: PMC3078671.
    144. Galante PA, Parmigiani RB, Zhao Q, Caballero OL, de Souza JE, Navarro FC, Gerber AL, Nicolás MF, Salim AC, Silva AP, Edsall L, Devalle S, Almeida LG, Ye Z, Kuan S, Pinheiro DG, Tojal I, Pedigoni RG, de Sousa RG, Oliveira TY, de Paula MG, Ohno-Machado L, Kirkness EF, Levy S, da Silva WA, Vasconcelos AT, Ren B, Zago MA, Strausberg RL, Simpson AJ, de Souza SJ, Camargo AA. Distinct patterns of somatic alterations in a lymphoblastoid and a tumor genome derived from the same individual. Nucleic Acids Res. 2011 Aug; 39(14):6056-68. PMID: 21493686; PMCID: PMC3152357.
    145. Kim J, Patel K, Jung H, Kuo WP, Ohno-Machado L. AnyExpress: integrated toolkit for analysis of cross-platform gene expression data using a fast interval matching algorithm. BMC Bioinformatics. 2011 Mar 17; 12:75. PMID: 21410990; PMCID: PMC3076267.
    146. Eckert MA, Lwin TM, Chang AT, Kim J, Danis E, Ohno-Machado L, Yang J. Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell. 2011 Mar 08; 19(3):372-86. PMID: 21397860; PMCID: PMC3072410.
    147. Jiang X, Osl M, Kim J, Ohno-Machado L. Smooth isotonic regression: a new method to calibrate predictive models. AMIA Jt Summits Transl Sci Proc. 2011; 2011:16-20. PMID: 22211175; PMCID: PMC3248752.
    148. Lehmannm H, Ohno-Machado L. Evaluation of informatics systems: beyond RCTs and beyond the hospital. J Am Med Inform Assoc. 2011 Mar-Apr; 18(2):110-1. PMID: 21385823; PMCID: PMC3116252.
    149. Ohno-Machado L. A new JAMIA. J Am Med Inform Assoc. 2011 Jan-Feb; 18(1):2. PMID: 21169617; PMCID: PMC3005883.
    150. Casas E, Kim J, Bendesky A, Ohno-Machado L, Wolfe CJ, Yang J. Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res. 2011 Jan 01; 71(1):245-54. PMID: 21199805; PMCID: PMC3025803.
    151. Ohno-Machado L. What's new in informatics. J Am Med Inform Assoc. 2011 Jan-Feb; 18(1):1. PMID: 21169616; PMCID: PMC3005884.
    152. Kim H, Choi J, Thompson S, Meeker L, Dykes P, Goldsmith D, Ohno-Machado L. Automating pressure ulcer risk assessment using documented patient data. Int J Med Inform. 2010 Dec; 79(12):840-8. PMID: 20869303.
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    153. Kim H, Choi J, Secalag L, Dibsie L, Boxwala A, Ohno-Machado L. Building an ontology for pressure ulcer risk assessment to allow data sharing and comparisons across hospitals. AMIA Annu Symp Proc. 2010 Nov 13; 2010:382-6. PMID: 21347005; PMCID: PMC3041354.
    154. Osl M, Dreiseitl S, Kim J, Patel K, Baumgartner C, Ohno-Machado L. Effect of data combination on predictive modeling: a study using gene expression data. AMIA Annu Symp Proc. 2010 Nov 13; 2010:567-71. PMID: 21347042; PMCID: PMC3041313.
    155. Sadow CA, Wheeler SC, Kim J, Ohno-Machado L, Silverman SG. Positive predictive value of CT urography in the evaluation of upper tract urothelial cancer. AJR Am J Roentgenol. 2010 Nov; 195(5):W337-43. PMID: 20966298.
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    156. Lacson R, Mbagwu M, Yousif H, Ohno-Machado L. Assessing the quality of annotations in asthma gene expression experiments. BMC Bioinformatics. 2010 Oct 28; 11 Suppl 9:S8. PMID: 21044366; PMCID: PMC2967749.
    157. Hinske LC, Galante PA, Kuo WP, Ohno-Machado L. A potential role for intragenic miRNAs on their hosts' interactome. BMC Genomics. 2010 Oct 01; 11:533. PMID: 20920310; PMCID: PMC3091682.
    158. Ohashi K, Ota S, Ohno-Machado L, Tanaka H. Smart medical environment at the point of care: auto-tracking clinical interventions at the bed side using RFID technology. Comput Biol Med. 2010 Jun; 40(6):545-54. PMID: 20471637.
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    159. Lacson R, Pitzer E, Kim J, Galante P, Hinske C, Ohno-Machado L. DSGeo: software tools for cross-platform analysis of gene expression data in GEO. J Biomed Inform. 2010 Oct; 43(5):709-15. PMID: 20435161; PMCID: PMC2934864.
    160. Pitzer E, Kim J, Patel K, Galante PA, Ohno-Machado L. PositionMatcher: A Fast Custom-Annotation Tool for Short DNA Sequences. AMIA Jt Summits Transl Sci Proc. 2010 Mar 01; 2010:25-9. PMID: 21347141; PMCID: PMC3041550.
    161. Pitzer E, Lacson R, Hinske C, Kim J, Galante PA, Ohno-Machado L. Towards large-scale sample annotation in gene expression repositories. BMC Bioinformatics. 2009 Sep 17; 10 Suppl 9:S9. PMID: 19761579; PMCID: PMC2745696.
    162. Lacson R, Pitzer E, Hinske C, Galante P, Ohno-Machado L. Evaluation of a large-scale biomedical data annotation initiative. BMC Bioinformatics. 2009 Sep 17; 10 Suppl 9:S10. PMID: 19761564; PMCID: PMC2745681.
    163. Ohno-Machado L. Lucila Ohno-Machado. Interview by Virginia Gewin. Nature. 2009 Jul 30; 460(7255):655. PMID: 19650208.
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    164. Racowsky C, Ohno-Machado L, Kim J, Biggers JD. Is there an advantage in scoring early embryos on more than one day? Hum Reprod. 2009 Sep; 24(9):2104-13. PMID: 19493872; PMCID: PMC2727402.
    165. Ohno-Machado L, Ellison D, Shortliffe EH. Presentation of the 2008 Morris F. Collen Award to Robert A. Greenes. J Am Med Inform Assoc. 2009 May-Jun; 16(3):413-8. PMID: 19606540; PMCID: PMC2732226.
    166. Matheny ME, Morrow DA, Ohno-Machado L, Cannon CP, Sabatine MS, Resnic FS. Validation of an automated safety surveillance system with prospective, randomized trial data. Med Decis Making. 2009 Mar-Apr; 29(2):247-56. PMID: 19015285; PMCID: PMC2743924.
    167. Ohashi K, Ota S, Ohno-Machado L, Tanaka H. Comparison of RFID systems for tracking clinical interventions at the bedside. AMIA Annu Symp Proc. 2008 Nov 06; 525-9. PMID: 18998888; PMCID: PMC2656010.
    168. Osl M, Ohno-Machado L, Baumgartner C, Tilg B, Dreiseitl S. Improving calibration of logistic regression models by local estimates. AMIA Annu Symp Proc. 2008 Nov 06; 535-9. PMID: 18998878; PMCID: PMC2656048.
    169. Fu S, Zhao H, Shi J, Abzhanov A, Crawford K, Ohno-Machado L, Zhou J, Du Y, Kuo WP, Zhang J, Jiang M, Jin JG. Peripheral arterial occlusive disease: global gene expression analyses suggest a major role for immune and inflammatory responses. BMC Genomics. 2008 Aug 01; 9:369. PMID: 18673543; PMCID: PMC2529314.
    170. Nygaard V, Liu F, Holden M, Kuo WP, Trimarchi J, Ohno-Machado L, Cepko CL, Frigessi A, Glad IK, Wiel MA, Hovig E, Lyng H. Validation of oligoarrays for quantitative exploration of the transcriptome. BMC Genomics. 2008 May 30; 9:258. PMID: 18513391; PMCID: PMC2430212.
    171. Hasina R, Whipple ME, Martin LE, Kuo WP, Ohno-Machado L, Lingen MW. Angiogenic heterogeneity in head and neck squamous cell carcinoma: biological and therapeutic implications. Lab Invest. 2008 Apr; 88(4):342-53. PMID: 18283272; PMCID: PMC2614382.
    172. Curtis DW, Pino EJ, Bailey JM, Shih EI, Waterman J, Vinterbo SA, Stair TO, Guttag JV, Greenes RA, Ohno-Machado L. SMART--an integrated wireless system for monitoring unattended patients. J Am Med Inform Assoc. 2008 Jan-Feb; 15(1):44-53. PMID: 17947629; PMCID: PMC2274866.
    173. Matheny ME, Ohno-Machado L, Resnic FS. Risk-adjusted sequential probability ratio test control chart methods for monitoring operator and institutional mortality rates in interventional cardiology. Am Heart J. 2008 Jan; 155(1):114-20. PMID: 18082501.
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    174. Matheny ME, Arora N, Ohno-Machado L, Resnic FS. Rare adverse event monitoring of medical devices with the use of an automated surveillance tool. AMIA Annu Symp Proc. 2007 Oct 11; 518-22. PMID: 18693890; PMCID: PMC2655807.
    175. Matheny ME, Morrow DA, Ohno-Machado L, Cannon CP, Resnic FS. Validating an automated outcomes surveillance application using data from a terminated randomized, controlled trial (OPUS [TIMI-16]). AMIA Annu Symp Proc. 2007 Oct 11; 1043. PMID: 18694141.
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    176. Curtis D, Bailey J, Pino E, Shih E, Greenes R, Guttag J, Stair T, Ohno-Machado L. Is redundancy in vital signs monitoring useful? AMIA Annu Symp Proc. 2007 Oct 11; 923. PMID: 18694023.
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    177. Sawa T, Yuji K, Kami M, Ohno-Machado L, Nakata Y. Current status of the Japanese cancer registry system: results of a nationwide survey. AMIA Annu Symp Proc. 2007 Oct 11; 1104. PMID: 18694201.
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    178. Stransky B, Barrera J, Ohno-Machado L, De Souza SJ. Modeling cancer: integration of "omics" information in dynamic systems. J Bioinform Comput Biol. 2007 Aug; 5(4):977-86. PMID: 17787066.
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    179. Liu F, Jenssen TK, Trimarchi J, Punzo C, Cepko CL, Ohno-Machado L, Hovig E, Kuo WP. Comparison of hybridization-based and sequencing-based gene expression technologies on biological replicates. BMC Genomics. 2007 Jun 07; 8:153. PMID: 17555589; PMCID: PMC1899500.
    180. Matheny ME, Resnic FS, Arora N, Ohno-Machado L. Effects of SVM parameter optimization on discrimination and calibration for post-procedural PCI mortality. J Biomed Inform. 2007 Dec; 40(6):688-97. PMID: 17600771; PMCID: PMC2170520.
    181. Galante PA, Trimarchi J, Cepko CL, de Souza SJ, Ohno-Machado L, Kuo WP. Automatic correspondence of tags and genes (ACTG): a tool for the analysis of SAGE, MPSS and SBS data. Bioinformatics. 2007 Apr 01; 23(7):903-5. PMID: 17277333.
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    182. Kuo WP, Liu F, Trimarchi J, Punzo C, Lombardi M, Sarang J, Whipple ME, Maysuria M, Serikawa K, Lee SY, McCrann D, Kang J, Shearstone JR, Burke J, Park DJ, Wang X, Rector TL, Ricciardi-Castagnoli P, Perrin S, Choi S, Bumgarner R, Kim JH, Short GF, Freeman MW, Seed B, Jensen R, Church GM, Hovig E, Cepko CL, Park P, Ohno-Machado L, Jenssen TK. A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Nat Biotechnol. 2006 Jul; 24(7):832-40. PMID: 16823376.
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    183. Talos IF, Zou KH, Ohno-Machado L, Bhagwat JG, Kikinis R, Black PM, Jolesz FA. Supratentorial low-grade glioma resectability: statistical predictive analysis based on anatomic MR features and tumor characteristics. Radiology. 2006 May; 239(2):506-13. PMID: 16641355; PMCID: PMC1475754.
    184. Vinterbo SA, Dreiseitl S, Ohno-Machado L. Approximation properties of haplotype tagging. BMC Bioinformatics. 2006 Jan 09; 7:8. PMID: 16401341; PMCID: PMC1395335.
    185. Ohno-Machado L, Resnic FS, Matheny ME. Prognosis in critical care. Annu Rev Biomed Eng. 2006; 8:567-99. PMID: 16834567.
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    186. Marin HF, Massad E, Marques EP, Ohno-Machado L. A certificate program in health informatics: Brazil/USA experience. Stud Health Technol Inform. 2006; 122:800. PMID: 17102389.
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    187. Matheny ME, Ohno-Machado L, Resnic FS. Monitoring device safety in interventional cardiology. J Am Med Inform Assoc. 2006 Mar-Apr; 13(2):180-7. PMID: 16357356; PMCID: PMC1447549.
    188. Weber G, Ohno-Machado L, Shieber S. Representation in stochastic search for phylogenetic tree reconstruction. J Biomed Inform. 2006 Feb; 39(1):43-50. PMID: 16359929.
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    189. Lasko TA, Bhagwat JG, Zou KH, Ohno-Machado L. The use of receiver operating characteristic curves in biomedical informatics. J Biomed Inform. 2005 Oct; 38(5):404-15. PMID: 16198999.
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    190. Carrino JA, Ohno-Machado L. Development of radiology prediction models using feature analysis. Acad Radiol. 2005 Apr; 12(4):415-21. PMID: 15831414.
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    191. Zou KH, Resnic FS, Talos IF, Goldberg-Zimring D, Bhagwat JG, Haker SJ, Kikinis R, Jolesz FA, Ohno-Machado L. A global goodness-of-fit test for receiver operating characteristic curve analysis via the bootstrap method. J Biomed Inform. 2005 Oct; 38(5):395-403. PMID: 16198998.
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    192. Vinterbo SA, Kim EY, Ohno-Machado L. Small, fuzzy and interpretable gene expression based classifiers. Bioinformatics. 2005 May 01; 21(9):1964-70. PMID: 15661797.
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    193. Matheny ME, Ohno-Machado L, Resnic FS. Exploration of a Bayesian updating tool to provide real-time safety monitoring for new medical devices. AMIA Annu Symp Proc. 2005; 1045. PMID: 16779332; PMCID: PMC1560574.
    194. Pino E, Ohno-Machado L, Wiechmann E, Curtis D. Real-time ECG algorithms for ambulatory patient monitoring. AMIA Annu Symp Proc. 2005; 604-8. PMID: 16779111; PMCID: PMC1560458.
    195. Marin HF, Massad E, Marques EP, Azevedo RS, Ohno-Machado L. Training health informatics professionals in Brazil: rationale for the development of a new certificate program. AMIA Annu Symp Proc. 2005; 1042. PMID: 16779329; PMCID: PMC1560621.
    196. Haker S, Wells WM, Warfield SK, Talos IF, Bhagwat JG, Goldberg-Zimring D, Mian A, Ohno-Machado L, Zou KH. Combining classifiers using their receiver operating characteristics and maximum likelihood estimation. Med Image Comput Comput Assist Interv. 2005; 8(Pt 1):506-14. PMID: 16685884; PMCID: PMC3681096.
    197. Sawa T, Funahara T, Nagatani H, Okahara M, Sase K, Nakata Y, Ohno-Machado L. WLAN PDA to improve efficiency in patient care documentation. AMIA Annu Symp Proc. 2005; 1107. PMID: 16779394; PMCID: PMC1560477.
    198. Butterworth R, Simovici DA, Santos GS, Ohno-Machado L. A greedy algorithm for supervised discretization. J Biomed Inform. 2004 Aug; 37(4):285-92. PMID: 15465481.
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    199. Ohno-Machado L. Research on machine learning issues in biomedical informatics modeling. J Biomed Inform. 2004 Aug; 37(4):221-3. PMID: 15465475.
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    200. Kuo WP, Kim EY, Trimarchi J, Jenssen TK, Vinterbo SA, Ohno-Machado L. A primer on gene expression and microarrays for machine learning researchers. J Biomed Inform. 2004 Aug; 37(4):293-303. PMID: 15465482.
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    201. Ohno-Machado L, Silveira PS, Vinterbo S. Protecting patient privacy by quantifiable control of disclosures in disseminated databases. Int J Med Inform. 2004 Aug; 73(7-8):599-606. PMID: 15246040.
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    202. Resnic FS, Zou KH, Do DV, Apostolakis G, Ohno-Machado L. Exploration of a bayesian updating methodology to monitor the safety of interventional cardiovascular procedures. Med Decis Making. 2004 Jul-Aug; 24(4):399-407. PMID: 15271278.
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    203. Jaroszewicz S, Simovici DA, Kuo WP, Ohno-Machado L. The Goodman-Kruskal coefficient and its applications in genetic diagnosis of cancer. IEEE Trans Biomed Eng. 2004 Jul; 51(7):1095-102. PMID: 15248526.
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    204. Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL. Genomic analysis of mouse retinal development. PLoS Biol. 2004 Sep; 2(9):E247. PMID: 15226823; PMCID: PMC439783.
    205. Weber G, Vinterbo S, Ohno-Machado L. Multivariate selection of genetic markers in diagnostic classification. Artif Intell Med. 2004 Jun; 31(2):155-67. PMID: 15219292.
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    206. Kuo WP, Whipple ME, Epstein JB, Jenssen TK, Santos GS, Ohno-Machado L, Sonis ST. Deciphering gene expression profiles generated from DNA microarrays and their applications in oral medicine. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 May; 97(5):584-91. PMID: 15153870.
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    207. Szot A, Jacobson FL, Munn S, Jazayeri D, Nardell E, Harrison D, Drosten R, Ohno-Machado L, Smeaton LM, Fraser HS. Diagnostic accuracy of chest X-rays acquired using a digital camera for low-cost teleradiology. Int J Med Inform. 2004 Feb; 73(1):65-73. PMID: 15036080.
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    208. Nimgaonkar A, Karnad DR, Sudarshan S, Ohno-Machado L, Kohane I. Prediction of mortality in an Indian intensive care unit. Comparison between APACHE II and artificial neural networks. Intensive Care Med. 2004 Feb; 30(2):248-253. PMID: 14727015.
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    209. Marin HF, Massad E, Marques EP, Ohno-Machado L. International training in health informatics: a Brazilian experience. Stud Health Technol Inform. 2004; 107(Pt 2):898-902. PMID: 15360942.
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    210. Holt TA, Ohno-Machado L. A nationwide adaptive prediction tool for coronary heart disease prevention. Br J Gen Pract. 2003 Nov; 53(496):866-70. PMID: 14702907; PMCID: PMC1314730.
    211. Albrecht A, Vinterbo SA, Ohno-Machado L. An Epicurean learning approach to gene-expression data classification. Artif Intell Med. 2003 May; 28(1):75-87. PMID: 12850314.
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    212. Kuo WP, Whipple ME, Jenssen TK, Todd R, Epstein JB, Ohno-Machado L, Sonis ST, Park PJ. Microarrays and clinical dentistry. J Am Dent Assoc. 2003 Apr; 134(4):456-62. PMID: 12733779.
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    213. Kuo WP, Hasina R, Ohno-Machado L, Lingen MW. Classification and identification of genes associated with oral cancer based on gene expression profiles. A preliminary study. N Y State Dent J. 2003 Feb; 69(2):23-6. PMID: 12703240.
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    214. Klapper DA, Weaver J, Fernandez H, Ohno-Machado L. Classification of movement states in Parkinson's disease using a wearable ambulatory monitor. AMIA Annu Symp Proc. 2003; 896. PMID: 14728401; PMCID: PMC1480298.
    215. Sawa T, Okahara M, Santo M, Schmidt U, Nakata Y, Morita S, Ohno-Machado L. Preoperative information management system using wireless PDAs. AMIA Annu Symp Proc. 2003; 995. PMID: 14728498; PMCID: PMC1480168.
    216. Sawa T, Ohno-Machado L. A neural network-based similarity index for clustering DNA microarray data. Comput Biol Med. 2003 Jan; 33(1):1-15. PMID: 12485626.
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    217. Resnic FS, Wainstein M, Lee MK, Behrendt D, Wainstein RV, Ohno-Machado L, Kirshenbaum JM, Rogers CD, Popma JJ, Piana R. No-reflow is an independent predictor of death and myocardial infarction after percutaneous coronary intervention. Am Heart J. 2003 Jan; 145(1):42-6. PMID: 12514653.
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    218. Kuo WP, Whipple ME, Sonis ST, Ohno-Machado L, Jenssen TK. Gene expression profiling by DNA microarrays and its application to dental research. Oral Oncol. 2002 Oct; 38(7):650-6. PMID: 12353490.
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    219. Dreiseitl S, Ohno-Machado L. Logistic regression and artificial neural network classification models: a methodology review. J Biomed Inform. 2002 Oct-Dec; 35(5-6):352-9. PMID: 12968784.
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    220. Kuo WP, Jenssen TK, Butte AJ, Ohno-Machado L, Kohane IS. Analysis of matched mRNA measurements from two different microarray technologies. Bioinformatics. 2002 Mar; 18(3):405-12. PMID: 11934739.
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    221. Kim JH, Kohane IS, Ohno-Machado L. Visualization and evaluation of clusters for exploratory analysis of gene expression data. J Biomed Inform. 2002 Feb; 35(1):25-36. PMID: 12415724.
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    222. Kuo WP, Jenssen TK, Park PJ, Lingen MW, Hasina R, Ohno-Machado L. Gene expression levels in different stages of progression in oral squamous cell carcinoma. Proc AMIA Symp. 2002; 415-9. PMID: 12474876; PMCID: PMC2244435.
    223. Anantraman V, Mikkelsen T, Khilnani R, Kumar VS, Pentland A, Ohno-Machado L. Open source handheld-based EMR for paramedics working in rural areas. Proc AMIA Symp. 2002; 12-6. PMID: 12463777; PMCID: PMC2244537.
    224. Marques EP, Marin HF, Massad E, Fraser H, Ohno-Machado L. Training in health informatics in Brazil. Stud Health Technol Inform. 2002; 90:757-60. PMID: 15460793.
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    225. Ray HN, Boxwala AA, Anantraman V, Ohno-Machado L. Providing context-sensitive decision-support based on WHO guidelines. Proc AMIA Symp. 2002; 637-41. PMID: 12463901; PMCID: PMC2244156.
    226. Ohno-Machado L, Vinterbo S, Dreiseitl S, Jenssen TK, Kuo W. Comparing imperfect measurements with the Bland-Altman technique: application in gene expression analysis. Proc AMIA Symp. 2002; 572-6. PMID: 12463888; PMCID: PMC2244491.
    227. Weber G, Vinterbo S, Ohno-Machado L. Building an asynchronous web-based tool for machine learning classification. Proc AMIA Symp. 2002; 869-73. PMID: 12463949; PMCID: PMC2244467.