Shirley Tsunoda

Title(s)	Professor Of Clinical, School of Pharmacy and Pharmaceutical Science
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Optimization of Antibiotics in Mothers and their Breastfed Infants Using Pharmacomicrobiomic and Metabolomic Analyses
NIH P50HD106463Sep 10, 2021 - Jul 31, 2026
Role: Co-Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Empirically establishing drug exposure records directly from untargeted metabolomics data. bioRxiv. 2024 Oct 10. Zhao HN, Kvitne KE, Brungs C, Mohan S, Charron-Lamoureux V, Bittremieux W, Tang R, Schmid R, Lamichhane S, El Abiead Y, Andalibi MS, Mannochio-Russo H, Ambre M, Avalon NE, Bryant M, Caraballo-Rodríguez AM, Maya MC, Chin L, Ellis RJ, Franklin D, Girod S, Gomes PWP, Hansen L, Heaton R, Iudicello JE, Jarmusch AK, Khatib L, Letendre S, Magyari S, McDonald D, Mohanty I, Cumsille A, Moore DJ, Rajkumar P, Ross DH, Sapre H, Shahneh MRZ, Thomas SP, Tribelhorn C, Tubb HM, Walker C, Wang CX, Xing S, Zemlin J, Zuffa S, Wishart DS, Kaddurah-Daouk R, Wang M, Raffatellu M, Zengler K, Pluskal T, Xu L, Knight R, Tsunoda SM, Dorrestein PC. PMID: 39416075; PMCID: PMC11482764.

View in: PubMed Mentions:
Noninvasive skin swab analysis detects environmental drug exposure of pharmacy staff. Clin Transl Sci. 2024 Oct; 17(10):e70022. Thompson S, Abelyan S, Panitchpakdi M, Zemlin J, Thomas S, Zhao HN, Dorrestein PC, Tsunoda SM. PMID: 39323235; PMCID: PMC11424816.

View in: PubMed Mentions: 1 Fields:
Med Medicine (General)
Translation:Humans PHPublic Health
Lower doses of carvedilol in Japanese heart failure patients with reduced ejection fraction could show the potential to be non-inferior to higher doses in US patients: An international collaborative observational study. PLoS One. 2024; 19(3):e0299510. Maeda M, Humber D, Hida E, Ohtani T, Wang G, Wu T, Takeda S, Situ JN, Hayashi J, Nonen S, Takeda T, Okamoto H, Hori M, Sakata Y, Fujio Y, Tsunoda SM. PMID: 38452137; PMCID: PMC10919845.

View in: PubMed Mentions: Fields:
Med Medicine (General)Sci Science
Translation:Humans
Transfer of antibiotics and their metabolites in human milk: Implications for infant health and microbiota. Pharmacotherapy. 2023 05; 43(5):442-451. Thomas SP, Denizer E, Zuffa S, Best BM, Bode L, Chambers CD, Dorrestein PC, Liu GY, Momper JD, Nizet V, Tsunoda SM, Tremoulet AH. PMID: 36181712; PMCID: PMC10763576.

View in: PubMed Mentions: 4 Fields:
Dru Drug Therapy
Translation:Humans Cells
An untargeted metabolomics analysis of exogenous chemicals in human milk and transfer to the infant. Clin Transl Sci. 2022 11; 15(11):2576-2582. Thomas S, Gauglitz JM, Tripathi A, Vargas F, Bertrand K, Kim JH, Chambers C, Dorrestein PC, Tsunoda SM. PMID: 36043481; PMCID: PMC9652431.

View in: PubMed Mentions: 5 Fields:
Med Medicine (General)
Translation:Humans
Non-invasive skin sampling detects systemically administered drugs in humans. PLoS One. 2022; 17(7):e0271794. Panitchpakdi M, Weldon KC, Jarmusch AK, Gentry EC, Choi A, Sepulveda Y, Aguirre S, Sun K, Momper JD, Dorrestein PC, Tsunoda SM. PMID: 35881585; PMCID: PMC9321436.

View in: PubMed Mentions: 6 Fields:
Med Medicine (General)Sci Science
Translation:Humans
Physicochemical properties determining drug detection in skin. Clin Transl Sci. 2022 03; 15(3):761-770. Bittremieux W, Advani RS, Jarmusch AK, Aguirre S, Lu A, Dorrestein PC, Tsunoda SM. PMID: 34793633; PMCID: PMC8932847.

View in: PubMed Mentions: 7 Fields:
Med Medicine (General)
Translation:Humans
Chemical Proportionality within Molecular Networks. Anal Chem. 2021 09 28; 93(38):12833-12839. Petras D, Caraballo-Rodríguez AM, Jarmusch AK, Molina-Santiago C, Gauglitz JM, Gentry EC, Belda-Ferre P, Romero D, Tsunoda SM, Dorrestein PC, Wang M. PMID: 34533933.

View in: PubMed Mentions: 9 Fields:
Che Chemistry Techniques
Translation:Humans
Contribution of the Gut Microbiome to Drug Disposition, Pharmacokinetic and Pharmacodynamic Variability. Clin Pharmacokinet. 2021 08; 60(8):971-984. Tsunoda SM, Gonzales C, Jarmusch AK, Momper JD, Ma JD. PMID: 33959897; PMCID: PMC8332605.

View in: PubMed Mentions: 22 Fields:
Pha Pharmacology
Translation:Humans Animals
Mtor inhibitors associated with higher cardiovascular adverse events-A large population database analysis. Clin Transplant. 2021 04; 35(4):e14228. Nguyen VN, Abagyan R, Tsunoda SM. PMID: 33476406.

View in: PubMed Mentions: 3 Fields:
Tra Transplantation
Translation:Humans
National survey of physicians' perspectives on pharmacogenetic testing in solid organ transplantation. Clin Transplant. 2020 10; 34(10):e14037. Deininger KM, Tsunoda SM, Hirsch JD, Anderson H, Lee YM, McIlvennan CK, Page RL, Tran JN, Aquilante CL. PMID: 32654213.

View in: PubMed Mentions: 9 Fields:
Tra Transplantation
Translation:Humans
Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. Clin Transl Sci. 2020 09; 13(5):972-984. Jarmusch AK, Vrbanac A, Momper JD, Ma JD, Alhaja M, Liyanage M, Knight R, Dorrestein PC, Tsunoda SM. PMID: 32216086; PMCID: PMC7485946.

View in: PubMed Mentions: 12 Fields:
Med Medicine (General)
Translation:Humans
Stakeholder perspectives of the clinical utility of pharmacogenomic testing in solid organ transplantation. Pharmacogenomics. 2019 12; 20(18):1291-1302. Deininger KM, Tran JN, Tsunoda SM, Young GK, Lee YM, Anderson HD, Page Ii RL, Hirsch JD, Aquilante CL. PMID: 31755847.

View in: PubMed Mentions: 5 Fields:
Gen Genetics Pha Pharmacology
Translation:Humans
Advancing Pharmacist Collaborative Care within Academic Health Systems. Pharmacy (Basel). 2019 Oct 11; 7(4). Awdishu L, Singh RF, Saunders I, Yam FK, Hirsch JD, Lorentz S, Atayee RS, Ma JD, Tsunoda SM, Namba J, Mnatzaganian CL, Painter NA, Watanabe JH, Lee KC, Daniels CD, Morello CM. PMID: 31614555; PMCID: PMC6958419.

View in: PubMed Mentions: 10
Assessing Students' Satisfaction with a Redesigned Pharmacology Course Series. Am J Pharm Educ. 2019 09; 83(7):6971. Brandl K, Schneid SD, Tsunoda SM, Awdishu L. PMID: 31619818; PMCID: PMC6788159.

View in: PubMed Mentions: 1 Fields:
Edu Education Pha Pharmacy
Translation:Humans
Initial Development toward Non-Invasive Drug Monitoring via Untargeted Mass Spectrometric Analysis of Human Skin. Anal Chem. 2019 07 02; 91(13):8062-8069. Jarmusch AK, Elijah EO, Vargas F, Bouslimani A, da Silva RR, Ernst M, Wang M, Del Rosario KK, Dorrestein PC, Tsunoda SM. PMID: 31074958.

View in: PubMed Mentions: 8 Fields:
Che Chemistry Techniques
Translation:Humans
Midazolam Limited Sampling Strategy With a Population Pharmacokinetic Approach to Simultaneously Estimate Cytochrome P450 (CYP) 3A Constitutive, Inhibition, and Induction/Activation Conditions in Healthy Adults. J Clin Pharmacol. 2019 11; 59(11):1495-1504. Yang J, Nikanjam M, Capparelli EV, Tsunoda SM, Greenberg HE, Penzak SR, Stoch SA, Bertino JS, Nafziger AN, Ma JD. PMID: 31051051.

View in: PubMed Mentions: 1 Fields:
Pha Pharmacology
Translation:Humans
Identification of Maltase Glucoamylase as a Biomarker of Acute Kidney Injury in Patients with Cirrhosis. Crit Care Res Pract. 2019; 2019:5912804. Awdishu L, Tsunoda S, Pearlman M, Kokoy-Mondragon C, Ghassemian M, Naviaux RK, Patton HM, Mehta RL, Vijay B, RamachandraRao SP. PMID: 31179128; PMCID: PMC6501271.

View in: PubMed Mentions: 6
Computational Removal of Undesired Mass Spectral Features Possessing Repeat Units via a Kendrick Mass Filter. J Am Soc Mass Spectrom. 2019 Feb; 30(2):268-277. da Silva RR, Vargas F, Ernst M, Nguyen NH, Bolleddu S, Del Rosario KK, Tsunoda SM, Dorrestein PC, Jarmusch AK. PMID: 30267361; PMCID: PMC6347485.

View in: PubMed Mentions: 5 Fields:
Che Chemistry Techniques
Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient. Case Rep Transplant. 2018; 2018:7410508. Patel S, Mendler MH, Valasek MA, Tsunoda SM. PMID: 30105113; PMCID: PMC6076919.

View in: PubMed Mentions: 3
Midazolam Single Time Point Concentrations to Estimate Exposure and Cytochrome P450 (CYP) 3A Constitutive Activity Utilizing Limited Sampling Strategy With a Population Pharmacokinetic Approach. J Clin Pharmacol. 2018 09; 58(9):1205-1213. Yang J, Patel M, Nikanjam M, Capparelli EV, Tsunoda SM, Greenberg HE, Penzak SR, Aubrey Stoch S, Bertino JS, Nafziger AN, Ma JD. PMID: 29663428.

View in: PubMed Mentions: 7 Fields:
Pha Pharmacology
Translation:Humans
Evaluation of Proposed In Vivo Probe Substrates and Inhibitors for Phenotyping Transporter Activity in Humans. J Clin Pharmacol. 2016 07; 56 Suppl 7:S82-98. Momper JD, Tsunoda SM, Ma JD. PMID: 27385182.

View in: PubMed Mentions: 3 Fields:
Pha Pharmacology
Translation:Humans Animals
Limited sampling strategy of partial area under the concentration-time curves to estimate midazolam systemic clearance for cytochrome P450 3A phenotyping. Ther Drug Monit. 2015 Feb; 37(1):84-9. Masters JC, Harano DM, Greenberg HE, Tsunoda SM, Jang IJ, Ma JD. PMID: 25004135; PMCID: PMC4282980.

View in: PubMed Mentions: 3 Fields:
Dru Drug Therapy
Translation:Humans
Evaluation of partial area under the concentration time curve to estimate midazolam apparent oral clearance for cytochrome P450 3A phenotyping. Drug Metabol Drug Interact. 2013; 28(4):217-23. Tai W, Gong SL, Tsunoda SM, Greenberg HE, Gorski JC, Penzak SR, Stoch SA, Ma JD. PMID: 24114901.

View in: PubMed Mentions: 4 Fields:
Pha Pharmacology
Translation:Humans Cells
Evaluation of intravenous midazolam limited sampling models to determine area under the concentration time curve during cytochrome P450 3A baseline, inhibition and induction or activation. Int J Clin Pharmacol Ther. 2012 Jul; 50(7):468-75. Nguyen AN, Hoffman JT, Tsunoda SM, Jang IJ, Ma JD. PMID: 22541751.

View in: PubMed Mentions: 3 Fields:
Dru Drug Therapy Pha Pharmacology
Translation:Humans
Interleukin-28B genotype testing to determine response to the combination of pegylated-interferon and ribavirin for the treatment of hepatitis C virus. PLoS Curr. 2011 Jan 08; 3:RRN1207. Nguyen CM, Mendes M, Tsunoda S, Ma JD. PMID: 21278901; PMCID: PMC3024597.

View in: PubMed Mentions: 2
Assessment of oral midazolam limited sampling strategies to predict area under the concentration time curve (AUC) during cytochrome P450 (CYP) 3A baseline, inhibition and induction or activation. Int J Clin Pharmacol Ther. 2010 Dec; 48(12):847-53. Ma JD, Nguyen ET, Tsunoda SM, Greenberg HE, Gorski JC, Penzak SR, Lee LS. PMID: 21084040.

View in: PubMed Mentions: 3 Fields:
Dru Drug Therapy Pha Pharmacology
Translation:Humans Cells
Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation. Clin Pharmacokinet. 2010 Apr; 49(4):223-37. Ma JD, Tsunoda SM, Bertino JS, Trivedi M, Beale KK, Nafziger AN. PMID: 20214407.

View in: PubMed Mentions: 18 Fields:
Pha Pharmacology
Translation:Humans
Cost minimization of medicare part D prescription drug plan expenditures. Am J Manag Care. 2009 Aug; 15(8):545-53. Patel RA, Lipton HL, Cutler TW, Smith AR, Tsunoda SM, Stebbins MR. PMID: 19670958.

View in: PubMed Mentions: 8 Fields:
Hea Health Services
Translation:Humans
Dietary effects on drug metabolism and transport. Clin Pharmacokinet. 2003; 42(13):1071-88. Harris RZ, Jang GR, Tsunoda S. PMID: 14531721.

View in: PubMed Mentions: 46 Fields:
Pha Pharmacology
Translation:Humans
Limited sampling strategy to predict AUC of the CYP3A phenotyping probe midazolam in adults: application to various assay techniques. J Clin Pharmacol. 2002 Apr; 42(4):376-82. Kim JS, Nafziger AN, Tsunoda SM, Choo EE, Streetman DS, Kashuba AD, Kulawy RW, Beck DJ, Rocci ML, Wilkinson GR, Greenblatt DJ, Bertino JS. PMID: 11936561.

View in: PubMed Mentions: 16 Fields:
Pha Pharmacology
Translation:Humans
Independent anchoring and assembly mechanisms of INAD signaling complexes in Drosophila photoreceptors. J Neurosci. 2001 Jan 01; 21(1):150-8. Tsunoda S, Sun Y, Suzuki E, Zuker C. PMID: 11150331; PMCID: PMC6762460.

View in: PubMed Mentions: 23 Fields:
Neu Neurology
Translation:Animals Cells
The organization of INAD-signaling complexes by a multivalent PDZ domain protein in Drosophila photoreceptor cells ensures sensitivity and speed of signaling. Cell Calcium. 1999 Nov; 26(5):165-71. Tsunoda S, Zuker CS. PMID: 10643554.

View in: PubMed Mentions: 26 Fields:
Cel Cell Biology Met Metabolism
Translation:Animals Cells
Specificity in signaling pathways: assembly into multimolecular signaling complexes. Curr Opin Genet Dev. 1998 Aug; 8(4):419-22. Tsunoda S, Sierralta J, Zuker CS. PMID: 9729717.

View in: PubMed Mentions: 10 Fields:
Gen Genetics
Translation:Animals Cells
A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature. 1997 Jul 17; 388(6639):243-9. Tsunoda S, Sierralta J, Sun Y, Bodner R, Suzuki E, Becker A, Socolich M, Zuker CS. PMID: 9230432.

View in: PubMed Mentions: 161 Fields:
Sci Science
Translation:Animals Cells