Jennifer Le

Title(s)Professor Of Clinical, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-6692-0884 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California San Diego, San Diego, CA06/2019Faculty Leadership Academy
    University of California San Diego, San Diego, CA06/2018Faculty Mentorship Training Program
    University of California San Diego, La Jolla, CAMAS09/2012Clinical Research
    Board of Pharmaceutical Specialties, Washington, DCBCPS08/2007Board Certification in Pharmacotherapy
    Board of Pharmaceutical Specialties, Washington, DCAD-ID08/2008Infectious Diseases Pharmacotherapy
    Long Beach Memorial & Miller Children's Hospital, Long Beach, CA06/2001Pharmacy Practice Residency
    University of California San Francisco, School of Pharmacy, San Francisco, CAPharmD06/2000Pharmacy
    University of California Los Angeles, Los Angeles, CABS06/1995Biology
    Collapse Awards and Honors
    US Food and Drug Administration (FDA)2018  - 2023Invited Advisory Board Member
    Agency for Healthcare Research and Quality (AHRQ)2020  - 2023Invited Study Section Member
    Pediatric ECMO Anticoagulation CollaborativE (PEACE) Consensus2020  - 2023Invited Expert Panel Member
    Sternfels Prize for Drug Safety Innovation2018Grand Prize Recipient (
    Infectious Diseases Society of America2017Fellow
    University of California San Diego2013Recognition Award for Outstanding Mentor
    California Society of Health-Systems Pharmacists2013Fellow
    American College of Clinical Pharmacy2011Fellow
    Long Beach Research Symposium2010Research Award for “Complications Associated with S. aureus Bacteremia in Children”
    Western University of Health Sciences, College of Pharmacy2009Faculty Service Award
    Asian Pacific Health Foundation2018  - 2023Invited Board Member
    ECMO-CENTRAL (ECMO ECMOCore Elements Needed for Trials Regulation And quality of Life)2023Invited Panel Member
    Patient-Centered Outcomes Research Institute (PCORI)2022Invited Study Section Member
    National Science Foundation (NSF)2023Invited Study Section Member
    American Institute of Biological Sciences (AIBS)2020Invited Study Section Member

    Collapse Overview 
    Collapse Overview
    Dr. Jennifer Le is Professor of Clinical Pharmacy at the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences. She received her Bachelors of Science in Biology from University of California, Los Angeles in 1995; PharmD from University of California, San Francisco in 2000; and Masters in Clinical Research from University of California, San Diego in 2012. As a board-certified pharmacotherapy specialist with added qualification in infectious diseases since 2007, Dr. Le has been involved in clinical pharmacy services in pediatric infectious diseases and patient-oriented research over 20 years. She is an invited member of the federal advisory board for the Food and Drug Administration’s (FDA) Antimicrobial Drugs Advisory Committee that makes official recommendations to FDA about safety and efficacy of antibiotics for use in the United States. Dr. Le is an invited member for the Agency for Healthcare Research and Quality (AHRQ), Patient-Centered Outcomes Research Institute (PCORI), and National Science Foundation (NSF). She is also an advisory board member of the Asian Pacific Health Foundation; has also been a member of an NIH Special Emphasis Panel and participates in Scientific Review Groups; is an invited editorial board member for Pediatric Pharmacotherapy, Pharmacotherapy Journal, Pediatric Medicine and Infectious Diseases and Therapy Journal; and invited program reviewer for the national board certification programs through the American College of Clinical Pharmacy, including Self-Assessment Programs in Pediatrics (PedSAP), Ambulatory Care (ACSAP), and Pharmacotherapy (PSAP).

    Dr. Le’s primary research encompasses four domains: (1) antimicrobial stewardship in pediatrics, (2) clinical pharmacy, (3) clinical pharmacology, (4) precision medicine with therapeutic drug monitoring, and (5) safety and effectiveness of medications in resistant infections in pediatrics across the wide age spectrum from infancy (including critically-ill premature neonates) to adolescence. She specializes in pharmacokinetics – the processes by which a drug is absorbed, distributed, metabolized and eliminated by the body – and pediatric clinical pharmacology research. She has published over 150 articles in reputable medical and pharmacy journals and books, including Pediatrics, Journal of Pediatrics, and Merck Manuals and serves as the second author of the 2020 national vancomycin guidelines endorsed by the American Society of Health-System Pharmacists, Infectious Diseases Society of America, Pediatric Infectious Diseases Society and Society of Infectious Diseases Pharmacists. Dr. Le was a past recipient of the American College of Clinical Pharmacy’s Investigator Development Award and the K23 Career Development Award from the National Institutes of Health for her research in pharmacokinetic-pharmacodynamic modeling of antibiotics in children. She also serves as an investigator for pharmacokinetic studies through the RO1, U54 & T32/34 award mechanisms for developmental and translational pharmacology of pediatric antimicrobial therapy funded by the National Institutes of Health. She was bestowed the honor of fellow of the Infectious Diseases Society of America, American College of Clinical Pharmacy and California Society of Health Systems Pharmacists; and received awards such as Sternfels Prize for Drug Safety Innovation and Outstanding Mentor at University of California, San Diego Faculty Mentor Program. Dr. Le is most proud of her passion and continued effort to improve pediatric health and wellness extending globally through her humanitarian work in Vietnam, Taiwan and for Jordan over the past 12 years.

    Collapse Research 
    Collapse Research Activities and Funding
    Pediatric Trials Network’s (PTN) Antibiotic Safety in Infants with Complicated Intra-abdominal Infections
    NIH/Duke University HHSN275201000003IAug 1, 2018 - Jul 30, 2019
    Role: Co-Investigator (Pharmacologist)
    Longitudinal Assessment of Beta-lactam Antibiotic Exposure in in Critically Ill Children with Sepsis in the PICU to Predict Dosing Requirements
    NIH R01HD095547Jul 28, 2018 - Jun 30, 2022
    Role: Co-Investigator
    Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
    NIH U54HD090259Sep 20, 2016 - Jun 30, 2021
    Role: Co-Investigator (Director of Community Outreach)
    Academic Training in Therapeutic Advancement for Child Health (ATTACH)
    NIH T32HD087978May 1, 2016 - Apr 30, 2026
    Role: Co-Investigator
    Pharmacokinetic-Pharmacodynamics of Antimicrobials in Resistant Infections
    NIH K23AI089978May 15, 2010 - Apr 30, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Merck Manual on Pharmacokinetics (Professional Version). 2023. Jennifer Le. . View Publication.
    2. Antimicrobial Susceptibility of Streptococcus pneumoniae from North America, Europe, Latin America, and the Asia-Pacific Region: Results From 20 Years of the SENTRY Antimicrobial Surveillance Program (1997-2016). Open Forum Infect Dis. 2019 Mar; 6(Suppl 1):S14-S23. Sader HS, Mendes RE, Le J, Denys G, Flamm RK, Jones RN. PMID: 30895211; PMCID: PMC6419902.
      View in: PubMed   Mentions: 23  
    3. Cost-effective analysis of low- versus high-dose colistin in the treatment of multi-drug resistant pneumonia in Saudi Arabia. Int J Clin Pharm. 2019 Feb; 41(1):1-2. Nazer LH, Le J. PMID: 30661216.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Optimizing Antibiotic Drug Therapy in Pediatrics: Current State and Future Needs. J Clin Pharmacol. 2018 10; 58 Suppl 10:S108-S122. Le J, Bradley JS. PMID: 30248202.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    5. Critical Review of Double-Carbapenem Therapy for the Treatment of Carbapenemase-Producing Klebsiella pneumoniae. Ann Pharmacother. 2019 01; 53(1):70-81. Mashni O, Nazer L, Le J. PMID: 30019911.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    6. Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates. Ther Drug Monit. 2018 02; 40(1):103-108. Le J, Poindexter B, Sullivan JE, Laughon M, Delmore P, Blackford M, Yogev R, James LP, Melloni C, Harper B, Mitchell J, Benjamin DK, Boakye-Agyeman F, Cohen-Wolkowiez M. PMID: 29271816; PMCID: PMC5764797.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    7. Quality and Clinical Outcomes Associated with a Gentamicin Use System Change for Managing Chorioamnionitis. J Med Syst. 2017 Nov 09; 41(12):202. Sauberan JB, Choi B, Paradyse AR, Le J. PMID: 29124501.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Pharmacokinetics of single-dose ceftaroline fosamil in children with cystic fibrosis. Pediatr Pulmonol. 2017 Nov; 52(11):1424-1434. Le J, Bradley JS, Hingtgen S, Skochko S, Black N, Jones RN, Lim M, Capparelli EV. PMID: 28910514.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsCTClinical Trials
    9. Augmented Renal Clearance Using Population-Based Pharmacokinetic Modeling in Critically Ill Pediatric Patients. Pediatr Crit Care Med. 2017 Sep; 18(9):e388-e394. Avedissian SN, Bradley E, Zhang D, Bradley JS, Nazer LH, Tran TM, Nguyen A, Le J. PMID: 28640009.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    10. Case report of transient mcr-1-haboring Escherichia coli with concurrent Staphylococcus aureus bacteremia in Long Beach, California. Diagn Microbiol Infect Dis. 2017 Dec; 89(4):303-304. Le J, Turner N, Deshpande LM, Davis AP, Castanheira M. PMID: 28987268.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Minimally Invasive Aortic Valve Replacement via Right Anterior Minithoracotomy and Central Aortic Cannulation: A 13-Year Experience. Innovations (Phila). 2017 Mar/Apr; 12(2):87-94. Bethencourt DM, Le J, Rodriguez G, Kalayjian RW, Thomas GS. PMID: 28346263.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    12. Pediatric Obesity: Pharmacokinetic Alterations and Effects on Antimicrobial Dosing. Pharmacotherapy. 2017 03; 37(3):361-378. Natale S, Bradley J, Nguyen WH, Tran T, Ny P, La K, Vivian E, Le J. PMID: 28079262.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    13. Evolution of Ceftaroline-Resistant Mrsa in a Child with Cystic Fibrosis Following Repeated Antibiotic Exposure. Pediatr Infect Dis J. 2016 Jul; 35(7):813-5. Cannavino CR, Mendes RE, Sader HS, Farrell DJ, Critchley IA, Biek D, Le J, Skochko SM, Jones RN, Bradley JS. PMID: 27093165.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    14. Vancomycin pharmacokinetics and predicted dosage requirements in pediatric cancer patients. J Oncol Pharm Pract. 2016 Jun; 22(3):448-53. Abdel Hadi O, Al Omar S, Nazer LH, Mubarak S, Le J. PMID: 26079639.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    15. High-dose colistin for microbiologically documented serious respiratory infections associated with carbapenem-resistant Acinetobacter baummannii in critically ill cancer patients: a retrospective cohort study. Infect Dis (Lond). 2015; 47(11):755-60. Nazer LH, Rihani S, Hawari FI, Le J. PMID: 26050703.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    16. Bayesian Estimation of Vancomycin Pharmacokinetics in Obese Children: Matched Case-Control Study. Clin Ther. 2015 Jun 01; 37(6):1340-51. Le J, Capparelli EV, Wahid U, Wu YS, Romanowski GL, Tran TM, Nguyen A, Bradley JS. PMID: 26031618; PMCID: PMC4475435.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    17. Effect of nebulized colistin on the ventilator circuit: a prospective pilot case- control study from a single cancer center. Mediterr J Hematol Infect Dis. 2015; 7(1):e2015032. Ghonimat IM, Nazer LH, Aqel F, Mohammad MK, Hawari FI, Le J. PMID: 25960860; PMCID: PMC4418373.
      View in: PubMed   Mentions:
    18. Pharmacodynamic Characteristics of Nephrotoxicity Associated With Vancomycin Use in Children. J Pediatric Infect Dis Soc. 2015 Dec; 4(4):e109-16. Le J, Ny P, Capparelli E, Lane J, Ngu B, Muus R, Romanowski G, Vo T, Bradley J. PMID: 26582878; PMCID: PMC4681388.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    19. Vancomycin monitoring in children using bayesian estimation. Ther Drug Monit. 2014 Aug; 36(4):510-8. Le J, Ngu B, Bradley JS, Murray W, Nguyen A, Nguyen L, Romanowski GL, Vo T, Capparelli EV. PMID: 24452067; PMCID: PMC4101060.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    20. Characterization of the population pharmacokinetics of ampicillin in neonates using an opportunistic study design. Antimicrob Agents Chemother. 2014 Jun; 58(6):3013-20. Tremoulet A, Le J, Poindexter B, Sullivan JE, Laughon M, Delmore P, Salgado A, Ian-U Chong S, Melloni C, Gao J, Benjamin DK, Capparelli EV, Cohen-Wolkowiez M, Administrative Core Committee of the Best Pharmaceuticals for Children Act-Pediatric Trials Network. PMID: 24614374; PMCID: PMC4068432.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCTClinical Trials
    21. Population-Based Pharmacokinetic Modeling of Vancomycin in Children with Renal Insufficiency. J Pharmacol Clin Toxicol. 2014; 2(1):1017-1026. Le J, Vaida F, Nguyen E, Adler-Shohet FC, Romanowski G, Kim J, Vo T, Capparelli EV. PMID: 25309945; PMCID: PMC4191860.
      View in: PubMed   Mentions: 5  
    22. Maximum tolerated osmolarity for peripheral administration of parenteral nutrition in pediatric patients. JPEN J Parenter Enteral Nutr. 2014 Sep; 38(7):847-51. Dugan S, Le J, Jew RK. PMID: 23851423.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    23. Improved vancomycin dosing in children using area under the curve exposure. Pediatr Infect Dis J. 2013 Apr; 32(4):e155-63. Le J, Bradley JS, Murray W, Romanowski GL, Tran TT, Nguyen N, Cho S, Natale S, Bui I, Tran TM, Capparelli EV. PMID: 23340565; PMCID: PMC3632448.
      View in: PubMed   Mentions: 91     Fields:    Translation:Humans
    24. Time to initiation of antifungal therapy for neonatal candidiasis. Antimicrob Agents Chemother. 2013 Jun; 57(6):2550-5. Le J, Tran TT, Bui I, Wang MK, Vo A, Adler-Shohet FC. PMID: 23507285; PMCID: PMC3716169.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    25. Foodborne botulism treated with heptavalent botulism antitoxin. Ann Pharmacother. 2013 Feb; 47(2):e12. Hill SE, Iqbal R, Cadiz CL, Le J. PMID: 23362041.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    26. Impact of the use of procalcitonin assay in hospitalized adult patients with pneumonia at a community acute care hospital. Infect Control Hosp Epidemiol. 2012 Apr; 33(4):424-6. Kook JL, Chao SR, Le J, Robinson PA. PMID: 22418643.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    27. In vitro activity of carbapenems alone and in combination with amikacin against KPC-producing Klebsiella pneumoniae. J Clin Med Res. 2011 May 19; 3(3):106-10. Le J, McKee B, Srisupha-Olarn W, Burgess DS. PMID: 21811540; PMCID: PMC3138406.
      View in: PubMed   Mentions: 16  
    28. Incidence and risk factors influencing the development of vancomycin nephrotoxicity in children. J Pediatr. 2011 Mar; 158(3):422-6. McKamy S, Hernandez E, Jahng M, Moriwaki T, Deveikis A, Le J. PMID: 20888013.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    29. Treatment of meningitis caused by vancomycin-resistant Enterococcus faecium: high-dose and combination daptomycin therapy. Ann Pharmacother. 2010 Dec; 44(12):2001-6. Le J, Bookstaver PB, Rudisill CN, Hashem MG, Iqbal R, James CL, Sakoulas G. PMID: 21119097.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    30. Complications associated with outpatient parenteral antibiotic therapy in children. Clin Pediatr (Phila). 2010 Nov; 49(11):1038-43. Le J, San Agustin M, Hernandez EA, Tran TT, Adler-Shohet FC. PMID: 20724346.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    31. Consensus summary of aerosolized antimicrobial agents: application of guideline criteria. Insights from the Society of Infectious Diseases Pharmacists. Pharmacotherapy. 2010 Jun; 30(6):562-84. Le J, Ashley ED, Neuhauser MM, Brown J, Gentry C, Klepser ME, Marr AM, Schiller D, Schwiesow JN, Tice S, VandenBussche HL, Wood GC, Society of Infectious Diseases Pharmacists Aerosolized Antimicrobials Task Force. PMID: 20500046.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    32. Aerosolized Delivery of Antifungal Agents. Curr Fungal Infect Rep. 2010 Jun; 4(2):96-102. Le J, Schiller DS. PMID: 20502511; PMCID: PMC2868999.
      View in: PubMed   Mentions: 6  
    33. Clonal dissemination of Klebsiella pneumoniae carbapenemase KPC-3 in Long Beach, California. J Clin Microbiol. 2010 Feb; 48(2):623-5. Le J, Castanheira M, Burgess DS, McKee B, Iqbal R, Jones RN. PMID: 20032252; PMCID: PMC2815646.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    34. Nephrotoxicity associated with amphotericin B deoxycholate in neonates. Pediatr Infect Dis J. 2009 Dec; 28(12):1061-3. Le J, Adler-Shohet FC, Nguyen C, Lieberman JM. PMID: 19935267.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    35. Impact of empiric antibiotic use on development of infections caused by extended-spectrum beta-lactamase bacteria in a neonatal intensive care unit. Pediatr Infect Dis J. 2008 Apr; 27(4):314-8. Le J, Nguyen T, Okamoto M, McKamy S, Lieberman JM. PMID: 18316990.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    36. Management of community-associated methicillin-resistant Staphylococcus aureus infections in children. Pharmacotherapy. 2006 Dec; 26(12):1758-70. Le J, Lieberman JM. PMID: 17125437.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    37. Adverse drug reactions among children over a 10-year period. Pediatrics. 2006 Aug; 118(2):555-62. Le J, Nguyen T, Law AV, Hodding J. PMID: 16882807.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    38. Urinary tract infections during pregnancy. Ann Pharmacother. 2004 Oct; 38(10):1692-701. Le J, Briggs GG, McKeown A, Bustillo G. PMID: 15340129.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
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