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    Maria Kounnas

    Address9500 Gilman Drive #0612
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Phase 1 clinical studies with the gamma-secretase modulator, NGP 555 to establish safety, pharmacokinetics, and biomarker efficacy
      NIH/NIA R01AG049702Aug 1, 2015 - Apr 30, 2018
      Role: Principal Investigator
      STRUCTURE AND FUNCTION OF GP330
      NIH/NHLBI F32HL008744Mar 29, 1993
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Kounnas M, Lane-Donovan C, Nowakowski DW, Herz J, Comer WT. NGP 555, a ?-Secretase Modulator, Lowers the Amyloid Biomarker, Aß42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents. Alzheimers Dement (N Y). 2017 Jan; 3(1):65-73. PMID: 28497107.
        View in: PubMed
      2. Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas M, Wagner SL, Parent AT, Thinakaran G. Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates. J Biol Chem. 2010 Dec 3; 285(49):38042-52. PMID: 20921220.
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      3. Kounnas M, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010 Sep 9; 67(5):769-80. PMID: 20826309.
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      4. Varvel NH, Bhaskar K, Kounnas M, Wagner SL, Yang Y, Lamb BT, Herrup K. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J Clin Invest. 2009 Dec; 119(12):3692-702. PMID: 19907078.
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      5. Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas M, Thinakaran G. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem. 2009 Feb 06; 284(6):3793-803. PMID: 19074428; PMCID: PMC2635050.
      6. Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas M, Thinakaran G. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. J Biol Chem. 2009 Jan 16; 284(3):1373-84. PMID: 19028695; PMCID: PMC2615504.
      7. Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, Nguyen PD, Placanica L, Wieland FT, Li YM, Kounnas M, Thinakaran G. Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Mol Neurodegener. 2007 Feb 08; 2:4. PMID: 17288597; PMCID: PMC1803014.
      8. Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas M, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem. 2006 Oct 27; 281(43):32240-53. PMID: 16945923.
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      9. Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas M, Lamb BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner SL. Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897. Biochem Pharmacol. 2005 Feb 15; 69(4):689-98. PMID: 15670587.
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      10. Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas M, Wagner SL, Troncoso JC, Kawas CH, Katzman R, Koo EH. Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. J Clin Invest. 2000 Nov; 106(9):1159-66. PMID: 11067868.
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      11. Strickland DK, Kounnas M. Mechanisms of Cellular Uptake of Thrombin-Antithrombin II Complexes Role of the Low-Density Lipoprotein Receptor-Related Protein as a Serpin-Enzyme Complex Receptor. Trends Cardiovasc Med. 1997 Jan; 7(1):9-16. PMID: 21235858.
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      12. Higazi AA, Upson RH, Cohen RL, Manuppello J, Bognacki J, Henkin J, McCrae KR, Kounnas M, Strickland DK, Preissner KT, Lawler J, Cines DB. Interaction of single-chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteins. Blood. 1996 Jul 15; 88(2):542-51. PMID: 8695802.
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      13. Kounnas M, Church FC, Argraves WS, Strickland DK. Cellular internalization and degradation of antithrombin III-thrombin, heparin cofactor II-thrombin, and alpha 1-antitrypsin-trypsin complexes is mediated by the low density lipoprotein receptor-related protein. J Biol Chem. 1996 Mar 15; 271(11):6523-9. PMID: 8626456.
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      14. Kounnas M, Moir RD, Rebeck GW, Bush AI, Argraves WS, Tanzi RE, Hyman BT, Strickland DK. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell. 1995 Jul 28; 82(2):331-40. PMID: 7543026.
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      15. Strickland DK, Kounnas M, Argraves WS. LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism. FASEB J. 1995 Jul; 9(10):890-8. PMID: 7615159.
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      16. Kounnas M, Loukinova EB, Stefansson S, Harmony JA, Brewer BH, Strickland DK, Argraves WS. Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin. J Biol Chem. 1995 Jun 02; 270(22):13070-5. PMID: 7768901.
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      17. FitzGerald DJ, Fryling CM, Zdanovsky A, Saelinger CB, Kounnas M, Winkles JA, Strickland D, Leppla S. Pseudomonas exotoxin-mediated selection yields cells with altered expression of low-density lipoprotein receptor-related protein. J Cell Biol. 1995 Jun; 129(6):1533-41. PMID: 7790352; PMCID: PMC2291175.
      18. Stefansson S, Kounnas M, Henkin J, Mallampalli RK, Chappell DA, Strickland DK, Argraves WS. gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex. J Cell Sci. 1995 Jun; 108 ( Pt 6):2361-8. PMID: 7673355.
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      19. Kounnas M, Chappell DA, Wong H, Argraves WS, Strickland DK. The cellular internalization and degradation of hepatic lipase is mediated by low density lipoprotein receptor-related protein and requires cell surface proteoglycans. J Biol Chem. 1995 Apr 21; 270(16):9307-12. PMID: 7721852.
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      20. Mikhailenko I, Kounnas M, Strickland DK. Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates the cellular internalization and degradation of thrombospondin. A process facilitated by cell-surface proteoglycans. J Biol Chem. 1995 Apr 21; 270(16):9543-9. PMID: 7721883.
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      21. Michelis D, Kounnas M, Argraves WS, Sanford ED, Borchelt JD, Wright JR. Interaction of surfactant protein A with cellular myosin. Am J Respir Cell Mol Biol. 1994 Dec; 11(6):692-700. PMID: 7946398.
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      22. Williams SE, Kounnas M, Argraves KM, Argraves WS, Strickland DK. The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the receptor-associated protein. An overview. Ann N Y Acad Sci. 1994 Sep 10; 737:1-13. PMID: 7524391.
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      23. Kounnas M, Stefansson S, Loukinova E, Argraves KM, Strickland DK, Argraves WS. An overview of the structure and function of glycoprotein 330, a receptor related to the alpha 2-macroglobulin receptor. Ann N Y Acad Sci. 1994 Sep 10; 737:114-23. PMID: 7944141.
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      24. Fitzgerald DJ, Fryling CM, Zdanovsky A, Saelinger CB, Kounnas M, Strickland DK, Leppla S. Selection of Pseudomonas exotoxin-resistant cells with altered expression of alpha 2MR/LRP. Ann N Y Acad Sci. 1994 Sep 10; 737:138-44. PMID: 7944142.
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      25. Kounnas M, Haudenschild CC, Strickland DK, Argraves WS. Immunological localization of glycoprotein 330, low density lipoprotein receptor related protein and 39 kDa receptor associated protein in embryonic mouse tissues. In Vivo. 1994 May-Jun; 8(3):343-51. PMID: 7803716.
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      26. Kounnas M, Henkin J, Argraves WS, Strickland DK. Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase. J Biol Chem. 1993 Oct 15; 268(29):21862-7. PMID: 7691818.
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      27. Kounnas M, Chappell DA, Strickland DK, Argraves WS. Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro. J Biol Chem. 1993 Jul 05; 268(19):14176-81. PMID: 7686151.
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      28. Kounnas M, Argraves WS, Strickland DK. The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330. J Biol Chem. 1992 Oct 15; 267(29):21162-6. PMID: 1400426.
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      29. Kounnas M, Morris RE, Thompson MR, FitzGerald DJ, Strickland DK, Saelinger CB. The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J Biol Chem. 1992 Jun 25; 267(18):12420-3. PMID: 1618748.
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      30. Kounnas M, Wolz RL, Gorbea CM, Bond JS. Meprin-A and -B. Cell surface endopeptidases of the mouse kidney. J Biol Chem. 1991 Sep 15; 266(26):17350-7. PMID: 1894622.
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      31. Ghosh S, Kounnas M, Grogan WM. Separation and differential activation of rat liver cytosolic cholesteryl ester hydrolase, triglyceride lipase and retinyl palmitate hydrolase by cholestyramine and protein kinases. Lipids. 1990 Apr; 25(4):221-5. PMID: 2345496.
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