Maria Kounnas

Title(s)Associate Project Scientist, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Phase 1 clinical studies with the gamma-secretase modulator, NGP 555 to establish safety, pharmacokinetics, and biomarker efficacy
    NIH/NIA R01AG049702Aug 1, 2015 - Apr 30, 2018
    Role: Principal Investigator
    STRUCTURE AND FUNCTION OF GP330
    NIH/NHLBI F32HL008744Mar 29, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Safety of Anti-Reelin Therapeutic Approaches for Chronic Inflammatory Diseases. Cells. 2024 Mar 27; 13(7). Calvier L, Alexander A, Marckx AT, Kounnas MZ, Durakoglugil M, Herz J. PMID: 38607022; PMCID: PMC11011630.
      View in: PubMed   Mentions:
    2. Circulating Reelin promotes inflammation and modulates disease activity in acute and long COVID-19 cases. Front Immunol. 2023; 14:1185748. Calvier L, Drelich A, Hsu J, Tseng CT, Mina Y, Nath A, Kounnas MZ, Herz J. PMID: 37441066; PMCID: PMC10333573.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. Apolipoprotein E receptor 2 deficiency decreases endothelial adhesion of monocytes and protects against autoimmune encephalomyelitis. Sci Immunol. 2021 08 27; 6(62). Calvier L, Manouchehri N, Sacharidou A, Mineo C, Shaul PW, Hui DY, Kounnas MZ, Stüve O, Herz J. PMID: 34452924; PMCID: PMC8627794.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    4. Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes. Arterioscler Thromb Vasc Biol. 2021 04; 41(4):1309-1318. Calvier L, Xian X, Lee RG, Sacharidou A, Mineo C, Shaul PW, Kounnas MZ, Tsai S, Herz J. PMID: 33626909; PMCID: PMC7990715.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    5. Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes. Sci Transl Med. 2020 08 12; 12(556). Calvier L, Demuth G, Manouchehri N, Wong C, Sacharidou A, Mineo C, Shaul PW, Monson NL, Kounnas MZ, Stüve O, Herz J. PMID: 32801146; PMCID: PMC7860587.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    6. Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines. J Neuroinflammation. 2019 Dec 06; 16(1):257. Pontecorvi P, Banki MA, Zampieri C, Zalfa C, Azmoon P, Kounnas MZ, Marchese C, Gonias SL, Mantuano E. PMID: 31810478; PMCID: PMC6896679.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    7. NGP 555, a γ-secretase modulator, shows a beneficial shift in the ratio of amyloid biomarkers in human cerebrospinal fluid at safe doses. Alzheimers Dement (N Y). 2019; 5:458-467. Kounnas MZ, Durakoglugil MS, Herz J, Comer WT. PMID: 31921961; PMCID: PMC6944734.
      View in: PubMed   Mentions: 2  
    8. NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents. Alzheimers Dement (N Y). 2017 Jan; 3(1):65-73. Kounnas MZ, Lane-Donovan C, Nowakowski DW, Herz J, Comer WT. PMID: 28497107; PMCID: PMC5421551.
      View in: PubMed   Mentions: 11  
    9. Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates. J Biol Chem. 2010 Dec 03; 285(49):38042-52. Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas MZ, Wagner SL, Parent AT, Thinakaran G. PMID: 20921220; PMCID: PMC2992238.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    10. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010 Sep 09; 67(5):769-80. Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. PMID: 20826309; PMCID: PMC2947312.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    11. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J Clin Invest. 2009 Dec; 119(12):3692-702. Varvel NH, Bhaskar K, Kounnas MZ, Wagner SL, Yang Y, Lamb BT, Herrup K. PMID: 19907078; PMCID: PMC2786797.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    12. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem. 2009 Feb 06; 284(6):3793-803. Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G. PMID: 19074428; PMCID: PMC2635050.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    13. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. J Biol Chem. 2009 Jan 16; 284(3):1373-84. Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G. PMID: 19028695; PMCID: PMC2615504.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    14. Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Mol Neurodegener. 2007 Feb 08; 2:4. Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, Nguyen PD, Placanica L, Wieland FT, Li YM, Kounnas MZ, Thinakaran G. PMID: 17288597; PMCID: PMC1803014.
      View in: PubMed   Mentions: 40     Fields:    
    15. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem. 2006 Oct 27; 281(43):32240-53. Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. PMID: 16945923.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    16. Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897. Biochem Pharmacol. 2005 Feb 15; 69(4):689-98. Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas MZ, Lamb BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner SL. PMID: 15670587.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    17. Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. J Clin Invest. 2000 Nov; 106(9):1159-66. Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas MZ, Wagner SL, Troncoso JC, Kawas CH, Katzman R, Koo EH. PMID: 11067868; PMCID: PMC301422.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
    18. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell. 1995 Jul 28; 82(2):331-40. Kounnas MZ, Moir RD, Rebeck GW, Bush AI, Argraves WS, Tanzi RE, Hyman BT, Strickland DK. PMID: 7543026.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
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