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Alice Yu

TitleRecall Faculty
InstitutionUniversity of California San Diego
DepartmentPediatrics
Address200 W. Arbor Drive #8447
San Diego CA 92103
Phone858-246-0027
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    Collapse Research 
    Collapse Research Activities and Funding
    Predicting toxicity and success of anti-GD2 immunotherapy of neuroblastoma
    NIH/NCI R01CA164132Apr 1, 2012 - Mar 31, 2015
    Role: Principal Investigator
    IMMUNE MONITOR FOR COG TRIAL OF ANTI-GD2 IN NEUROBLASTOMA
    FDA R01FD002319Sep 30, 2003 - May 31, 2010
    Role: Principal Investigator
    CLINICAL TRIAL OF ANTIID VACCINE FOR NEUROBLASTOMA
    NIH/NCI R21CA078806Jul 1, 1998 - Jun 30, 2000
    Role: Principal Investigator
    EXPLOITATION OF FREQUENT P16 DELETION IN T-ALL THERAPY
    NIH/NCI R21CA070397Apr 1, 1996 - Mar 31, 1998
    Role: Principal Investigator
    CLINICAL UTILITY OF A NEUROBLASTOMA MONOCLONAL ANTIBODY
    NIH/NCI R01CA040186Sep 1, 1985 - Nov 30, 1988
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kuo HH, Lin RJ, Hung JT, Hsieh CB, Hung TH, Lo FY, Ho MY, Yeh CT, Huang YL, Yu J, Yu A. High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma. Sci Rep. 2017 Sep 07; 7(1):10750. PMID: 28883415.
      View in: PubMed
    2. Erbe AK, Wang W, Reville PK, Carmichael L, Kim K, Mendonca EA, Song Y, Hank JA, London WB, Naranjo A, Hong F, Hogarty MD, Maris JM, Park JR, Ozkaynak MF, Miller JS, Gilman AL, Kahl B, Yu A, Sondel PM. HLA-Bw4-I-80 Isoform Differentially Influences Clinical Outcome As Compared to HLA-Bw4-T-80 and HLA-A-Bw4 Isoforms in Rituximab or Dinutuximab-Based Cancer Immunotherapy. Front Immunol. 2017; 8:675. PMID: 28659916.
      View in: PubMed
    3. Mody R, Naranjo A, Van Ryn C, Yu A, London WB, Shulkin BL, Parisi MT, Servaes SE, Diccianni MB, Sondel PM, Bender JG, Maris JM, Park JR, Bagatell R. Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial. Lancet Oncol. 2017 Jul; 18(7):946-957. PMID: 28549783.
      View in: PubMed
    4. Batova A, Altomare D, Creek KE, Naviaux RK, Wang L, Li K, Green E, Williams R, Naviaux JC, Diccianni M, Yu A. Englerin A induces an acute inflammatory response and reveals lipid metabolism and ER stress as targetable vulnerabilities in renal cell carcinoma. PLoS One. 2017; 12(3):e0172632. PMID: 28296891.
      View in: PubMed
    5. Carvunis AR, Wang T, Skola D, Yu A, Chen J, Kreisberg JF, Ideker T. Evidence for a common evolutionary rate in metazoan transcriptional networks. Elife. 2015 Dec 18; 4. PMID: 26682651.
      View in: PubMed
    6. Williams RT, Yu A, Diccianni MB, Theodorakis EA, Batova A. Erratum: renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy. J Exp Clin Cancer Res. 2014 Dec 05; 33:95. PMID: 25480670; PMCID: PMC4272799.
    7. Sonawane P, Cho HE, Tagde A, Verlekar D, Yu A, Reynolds CP, Kang MH. Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma. Br J Pharmacol. 2014 Dec; 171(23):5330-44. PMID: 25039756; PMCID: PMC4294043.
    8. Cheng JY, Wang SH, Lin J, Tsai YC, Yu J, Wu JC, Hung JT, Lin JJ, Wu YY, Yeh KT, Yu A. Globo-H ceramide shed from cancer cells triggers translin-associated factor X-dependent angiogenesis. Cancer Res. 2014 Dec 01; 74(23):6856-66. PMID: 25281721.
      View in: PubMed
    9. Chang CH, Fan TC, Yu JC, Liao GS, Lin YC, Shih AC, Li WH, Yu A. The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer. J Transl Med. 2014 Sep 30; 12:257. PMID: 25266482; PMCID: PMC4189660.
    10. Fu CH, Lin RJ, Yu J, Chang WW, Liao GS, Chang WY, Tseng LM, Tsai YF, Yu JC, Yu A. A novel oncogenic role of inositol phosphatase SHIP2 in ER-negative breast cancer stem cells: involvement of JNK/vimentin activation. Stem Cells. 2014 Aug; 32(8):2048-60. PMID: 24802135.
      View in: PubMed
    11. Barnhill LM, Williams RT, Cohen O, Kim Y, Batova A, Mielke JA, Messer K, Pu M, Bao L, Yu A, Diccianni MB. High expression of CAI2, a 9p21-embedded long noncoding RNA, contributes to advanced-stage neuroblastoma. Cancer Res. 2014 Jul 15; 74(14):3753-63. PMID: 25028366; PMCID: PMC4126165.
    12. Hung JT, Tsai YC, Lin WD, Jan JT, Lin KH, Huang JR, Cheng JY, Chen MW, Wong CH, Yu A. Potent adjuvant effects of novel NKT stimulatory glycolipids on hemagglutinin based DNA vaccine for H5N1 influenza virus. Antiviral Res. 2014 Jul; 107:110-8. PMID: 24786174.
      View in: PubMed
    13. Terme M, Dorvillius M, Cochonneau D, Chaumette T, Xiao W, Diccianni MB, Barbet J, Yu A, Paris F, Sorkin LS, Birklé S. Chimeric antibody c.8B6 to O-acetyl-GD2 mediates the same efficient anti-neuroblastoma effects as therapeutic ch14.18 antibody to GD2 without antibody induced allodynia. PLoS One. 2014; 9(2):e87210. PMID: 24520328; PMCID: PMC3919714.
    14. Williams RT, Barnhill LM, Kuo HH, Lin WD, Batova A, Yu A, Diccianni MB. Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth. PLoS One. 2014; 9(2):e88219. PMID: 24505435; PMCID: PMC3914946.
    15. Kelner MJ, Diccianni MB, Yu A, Rutherford MR, Estes LA, Morgenstern R. Absence of MGST1 mRNA and protein expression in human neuroblastoma cell lines and primary tissue. Free Radic Biol Med. 2014 Apr; 69:167-71. PMID: 24486338; PMCID: PMC4010302.
    16. Williams RT, Yu A, Diccianni MB, Theodorakis EA, Batova A. Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy. J Exp Clin Cancer Res. 2013 Aug 20; 32:57. PMID: 23958461; PMCID: PMC3765946.
    17. Kreissman SG, Seeger RC, Matthay KK, London WB, Sposto R, Grupp SA, Haas-Kogan DA, Laquaglia MP, Yu A, Diller L, Buxton A, Park JR, Cohn SL, Maris JM, Reynolds CP, Villablanca JG. Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial. Lancet Oncol. 2013 Sep; 14(10):999-1008. PMID: 23890779; PMCID: PMC3963485.
    18. Chang WW, Lin RJ, Yu J, Chang WY, Fu CH, Lai A, Yu JC, Yu A. The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors. Breast Cancer Res. 2013 May 12; 15(3):R39. PMID: 23663564; PMCID: PMC3706809.
    19. Chan YT, Lin YC, Lin RJ, Kuo HH, Thang WC, Chiu KP, Yu A. Concordant and discordant regulation of target genes by miR-31 and its isoforms. PLoS One. 2013; 8(3):e58169. PMID: 23472152; PMCID: PMC3589381.
    20. Unguru Y, Joffe S, Fernandez CV, Yu A. Ethical issues for control-arm patients after revelation of benefits of experimental therapy: a framework modeled in neuroblastoma. J Clin Oncol. 2013 Feb 10; 31(5):641-6. PMID: 23295797; PMCID: PMC3565183.
    21. Hsieh MH, Hung JT, Liw YW, Lu YJ, Wong CH, Yu A, Liang PH. Synthesis and evaluation of acyl-chain- and galactose-6''-modified analogues of a-GalCer for NKT cell activation. Chembiochem. 2012 Jul 23; 13(11):1689-97. PMID: 22730199.
      View in: PubMed
    22. Matthay KK, George RE, Yu A. Promising therapeutic targets in neuroblastoma. Clin Cancer Res. 2012 May 15; 18(10):2740-53. PMID: 22589483; PMCID: PMC3382042.
    23. Guizzunti G, Theodorakis EA, Yu A, Zurzolo C, Batova A. Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance? Invest New Drugs. 2012 Oct; 30(5):1841-8. PMID: 21898184; PMCID: PMC3405192.
    24. Liang YJ, Kuo HH, Lin CH, Chen YY, Yang BC, Cheng YY, Yu A, Khoo KH, Yu J. Switching of the core structures of glycosphingolipids from globo- and lacto- to ganglio-series upon human embryonic stem cell differentiation. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22564-9. PMID: 21149694; PMCID: PMC3012484.
    25. Yu A, Gilman AL, Ozkaynak MF, London WB, Kreissman SG, Chen HX, Smith M, Anderson B, Villablanca JG, Matthay KK, Shimada H, Grupp SA, Seeger R, Reynolds CP, Buxton A, Reisfeld RA, Gillies SD, Cohn SL, Maris JM, Sondel PM. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010 Sep 30; 363(14):1324-34. PMID: 20879881; PMCID: PMC3086629.
    26. Batova A, Altomare D, Chantarasriwong O, Ohlsen KL, Creek KE, Lin YC, Messersmith A, Yu A, Yu J, Theodorakis EA. The synthetic caged garcinia xanthone cluvenone induces cell stress and apoptosis and has immune modulatory activity. Mol Cancer Ther. 2010 Nov; 9(11):2869-78. PMID: 20881270; PMCID: PMC2978789.
    27. Lin RJ, Lin YC, Chen J, Kuo HH, Chen YY, Diccianni MB, London WB, Chang CH, Yu A. microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma. Cancer Res. 2010 Oct 15; 70(20):7841-50. PMID: 20805302; PMCID: PMC4095771.
    28. Lin RJ, Lin YC, Yu A. miR-149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells. Mol Carcinog. 2010 Aug; 49(8):719-27. PMID: 20623644.
      View in: PubMed
    29. Lai CY, Hung JT, Lin HH, Yu A, Chen SH, Tsai YC, Shao LE, Yang WB, Yu J. Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro. Vaccine. 2010 Jul 12; 28(31):4945-54. PMID: 20653103.
      View in: PubMed
    30. Yu A, Birke K, Moriniere J, Welge-Lüssen U. TGF-{beta}2 induces senescence-associated changes in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5718-23. PMID: 20554622.
      View in: PubMed
    31. Sorkin LS, Otto M, Baldwin WM, Vail E, Gillies SD, Handgretinger R, Barfield RC, Ming Yu H, Yu A. Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia. Pain. 2010 Apr; 149(1):135-42. PMID: 20171010; PMCID: PMC3755890.
    32. Angiolillo AL, Yu A, Reaman G, Ingle AM, Secola R, Adamson PC. A phase II study of Campath-1H in children with relapsed or refractory acute lymphoblastic leukemia: a Children's Oncology Group report. Pediatr Blood Cancer. 2009 Dec; 53(6):978-83. PMID: 19637330; PMCID: PMC3120889.
    33. Lo TC, Barnhill LM, Kim Y, Nakae EA, Yu A, Diccianni MB. Inactivation of SHIP1 in T-cell acute lymphoblastic leukemia due to mutation and extensive alternative splicing. Leuk Res. 2009 Nov; 33(11):1562-6. PMID: 19473701; PMCID: PMC2735879.
    34. Lee CH, Chou TC, Su TL, Yu J, Shao LE, Yu A. BO-0742, a derivative of AHMA and N-mustard, has selective toxicity to drug sensitive and drug resistant leukemia cells and solid tumors. Cancer Lett. 2009 Apr 18; 276(2):204-11. PMID: 19108949.
      View in: PubMed
    35. Gilman AL, Ozkaynak MF, Matthay KK, Krailo M, Yu A, Gan J, Sternberg A, Hank JA, Seeger R, Reaman GH, Sondel PM. Phase I study of ch14.18 with granulocyte-macrophage colony-stimulating factor and interleukin-2 in children with neuroblastoma after autologous bone marrow transplantation or stem-cell rescue: a report from the Children's Oncology Group. J Clin Oncol. 2009 Jan 01; 27(1):85-91. PMID: 19047298; PMCID: PMC2645092.
    36. Huggins R, Li LH, Lin YC, Yu A, Yang HC. Nonparametric estimation of LOH using Affymetrix SNP genotyping arrays for unpaired samples. J Hum Genet. 2008; 53(11-12):983-90. PMID: 18989737.
      View in: PubMed
    37. Chang WW, Lee CH, Lee P, Lin J, Hsu CW, Hung JT, Lin JJ, Yu JC, Shao LE, Yu J, Wong CH, Yu A. Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11667-72. PMID: 18685093; PMCID: PMC2575305.
    38. Lin YC, Kuo MW, Yu J, Kuo HH, Lin RJ, Lo WL, Yu A. c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development. Mol Biol Evol. 2008 Oct; 25(10):2189-98. PMID: 18667440.
      View in: PubMed
    39. Yang HC, Huang MC, Li LH, Lin CH, Yu A, Diccianni MB, Wu JY, Chen YT, Fann CS. MPDA: microarray pooled DNA analyzer. BMC Bioinformatics. 2008 Apr 15; 9:196. PMID: 18412951; PMCID: PMC2387178.
    40. Lin YC, Hsieh LC, Kuo MW, Yu J, Kuo HH, Lo WL, Lin RJ, Yu A, Li WH. Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development. Mol Biol Evol. 2007 Nov; 24(11):2525-34. PMID: 17890240.
      View in: PubMed
    41. Batova A, Lam T, Wascholowski V, Yu A, Giannis A, Theodorakis EA. Synthesis and evaluation of caged Garcinia xanthones. Org Biomol Chem. 2007 Feb 07; 5(3):494-500. PMID: 17252132.
      View in: PubMed
    42. Ling TY, Kuo MD, Li CL, Yu A, Huang YH, Wu TJ, Lin YC, Chen SH, Yu J. Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro. Proc Natl Acad Sci U S A. 2006 Jun 20; 103(25):9530-5. PMID: 16772384; PMCID: PMC1480441.
    43. Batova A, Cottam H, Yu J, Diccianni MB, Carrera CJ, Yu A. EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. Blood. 2006 Feb 01; 107(3):898-903. PMID: 16234352; PMCID: PMC1895892.
    44. Loh KC, Willert J, Meltzer H, Roberts W, Kerlin B, Kadota R, Levy M, White G, Geddis A, Schiff D, Martin L, Yu A, Kung F, Spear MA. Temozolomide and radiation for aggressive pediatric central nervous system malignancies. J Pediatr Hematol Oncol. 2005 May; 27(5):254-8. PMID: 15891559.
      View in: PubMed
    45. Gebauer S, Yu A, Omura-Minamisawa M, Batova A, Diccianni MB. Expression profiles and clinical relationships of ID2, CDKN1B, and CDKN2A in primary neuroblastoma. Genes Chromosomes Cancer. 2004 Dec; 41(4):297-308. PMID: 15390183.
      View in: PubMed
    46. Diccianni MB, Yu J, Meppelink G, de Vries M, Shao L, Gebauer S, Shih H, Roberts W, Kilcoin NP, Pullen J, Carson DA, Yu A. 3-amino thioacridone inhibits DNA synthesis and induce DNA damage in T-cell acute lymphoblastic leukemia (T-ALL) in a p16-dependent manner. J Exp Ther Oncol. 2004 Oct; 4(3):223-37. PMID: 15724842.
      View in: PubMed
    47. McGowan KA, Nyhan WL, Barshop BA, Naviaux RK, Yu A, Haas RH, Townsend JJ. The role of methionine in ethylmalonic encephalopathy with petechiae. Arch Neurol. 2004 Apr; 61(4):570-4. PMID: 15096407.
      View in: PubMed
    48. Houghton PJ, Adamson PC, Blaney S, Fine HA, Gorlick R, Haber M, Helman L, Hirschfeld S, Hollingshead MG, Israel MA, Lock RB, Maris JM, Merlino G, Patterson W, Reynolds CP, Shannon K, Yu A, Yu J, Smith MA. Testing of new agents in childhood cancer preclinical models: meeting summary. Clin Cancer Res. 2002 Dec; 8(12):3646-57. PMID: 12473573.
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    49. Batova A, Shao LE, Diccianni MB, Yu A, Tanaka T, Rephaeli A, Nudelman A, Yu J. The histone deacetylase inhibitor AN-9 has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines. Blood. 2002 Nov 01; 100(9):3319-24. PMID: 12384433.
      View in: PubMed
    50. Kletzel M, Katzenstein HM, Haut PR, Yu A, Morgan E, Reynolds M, Geissler G, Marymount MH, Liu D, Kalapurakal JA, Shore RM, Bardo DM, Schmoldt J, Rademaker AW, Cohn SL. Treatment of high-risk neuroblastoma with triple-tandem high-dose therapy and stem-cell rescue: results of the Chicago Pilot II Study. J Clin Oncol. 2002 May 01; 20(9):2284-92. PMID: 11980999.
      View in: PubMed
    51. Broome HE, Yu A, Diccianni M, Camitta BM, Monia BP, Dean NM. Inhibition of Bcl-xL expression sensitizes T-cell acute lymphoblastic leukemia cells to chemotherapeutic drugs. Leuk Res. 2002 Mar; 26(3):311-6. PMID: 11792421.
      View in: PubMed