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Michael Hogan

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0623A
La Jolla CA 92093
Phone858-534-2773
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    Collapse Research 
    Collapse Research Activities and Funding
    Assessing and Alleviating Skeletal Muscle Ca2+ Handling Dysfunction in Sarcopenia
    NIH/NIAMS R01AR069577Mar 10, 2017 - Dec 31, 2021
    Role: Principal Investigator
    Assessing and Alleviating Ca2+ Handling Dysfunction in Sarcopenia
    NIH/NIA R56AG047929Sep 1, 2015 - Aug 31, 2016
    Role: Principal Investigator
    Mechanisms of Adaptation to Exercise in Health and COPD
    NIH/NHLBI P01HL091830Dec 8, 2008 - Nov 30, 2014
    Role: Co-Investigator
    Oxygen dependence of ROS generation in contracting single isolated myofibers
    NIH/NIAMS R01AR040155Sep 30, 1991 - Mar 31, 2014
    Role: Principal Investigator
    DETERMINANTS OF MUSCLE MAXIMAL O2 UPTAKE AND PERFORMANCE
    NIH/NIAMS R29AR040155Sep 30, 1991 - Aug 31, 1996
    Role: Principal Investigator
    PHYSIOLOGICAL CONSEQUENCES OF PULMONARY DISEASE
    NIH/NHLBI P01HL017731Feb 1, 1975 - Apr 30, 2006
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Gandra PG, Shiah AA, Nogueira L, Hogan MC. A mitochondrial-targeted antioxidant improves myofilament Ca2+ sensitivity during prolonged low frequency force depression at low PO2. J Physiol. 2018 Mar 15; 596(6):1079-1089. PMID: 29334129.
      View in: PubMed
    2. Hogan MC, Powers SK. Overview of The Journal of Physiology Special Issue on the 'Biomedical basis of elite performance'. J Physiol. 2017 May 01; 595(9):2769-2770. PMID: 28452136.
      View in: PubMed
    3. Kent JA, Ørtenblad N, Hogan MC, Poole DC, Musch TI. No Muscle Is an Island: Integrative Perspectives on Muscle Fatigue. Med Sci Sports Exerc. 2016 11; 48(11):2281-2293. PMID: 27434080.
      View in: PubMed
    4. Powers SK, Hogan MC. Exercise and oxidative stress. J Physiol. 2016 09 15; 594(18):5079-80. PMID: 27629081.
      View in: PubMed
    5. Knapp AE, Goldberg D, Delavar H, Trisko BM, Tang K, Hogan MC, Wagner PD, Breen EC. Skeletal myofiber VEGF regulates contraction-induced perfusion and exercise capacity but not muscle capillarity in adult mice. Am J Physiol Regul Integr Comp Physiol. 2016 07 01; 311(1):R192-9. PMID: 27225953; PMCID: PMC4967234 [Available on 07/01/17].
    6. Stary CM, Hogan MC. Cytosolic calcium transients are a determinant of contraction-induced HSP72 transcription in single skeletal muscle fibers. J Appl Physiol (1985). 2016 May 15; 120(10):1260-6. PMID: 26869714; PMCID: PMC4867320 [Available on 05/15/17].
    7. Moreno-Ulloa A, Nogueira L, Rodriguez A, Barboza J, Hogan MC, Ceballos G, Villarreal F, Ramirez-Sanchez I. Recovery of Indicators of Mitochondrial Biogenesis, Oxidative Stress, and Aging With (-)-Epicatechin in Senile Mice. J Gerontol A Biol Sci Med Sci. 2015 Nov; 70(11):1370-8. PMID: 25143004; PMCID: PMC4715241 [Available on 11/01/16].
    8. Delavar H, Nogueira L, Wagner PD, Hogan MC, Metzger D, Breen EC. Skeletal myofiber VEGF is essential for the exercise training response in adult mice. Am J Physiol Regul Integr Comp Physiol. 2014 Apr 15; 306(8):R586-95. PMID: 24523345; PMCID: PMC4043130.
    9. Zuo L, Hallman AH, Roberts WJ, Wagner PD, Hogan MC. Superoxide release from contracting skeletal muscle in pulmonary TNF-a overexpression mice. Am J Physiol Regul Integr Comp Physiol. 2014 Jan 01; 306(1):R75-81. PMID: 24196666; PMCID: PMC3921307.
    10. Gutierrez-Salmean G, Ciaraldi TP, Nogueira L, Barboza J, Taub PR, Hogan MC, Henry RR, Meaney E, Villarreal F, Ceballos G, Ramirez-Sanchez I. Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. J Nutr Biochem. 2014 Jan; 25(1):91-4. PMID: 24314870; PMCID: PMC3857584.
    11. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Gonzalez-Basurto S, Coral-Vazquez R, Perkins G, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. Perturbations in skeletal muscle sarcomere structure in patients with heart failure and type 2 diabetes: restorative effects of (-)-epicatechin-rich cocoa. Clin Sci (Lond). 2013 Oct; 125(8):383-9. PMID: 23642227.
      View in: PubMed
    12. Ramirez-Sanchez I, Taub PR, Ciaraldi TP, Nogueira L, Coe T, Perkins G, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. (-)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients. Int J Cardiol. 2013 Oct 09; 168(4):3982-3990. PMID: 23870648; PMCID: PMC3805662.
    13. Nogueira L, Shiah AA, Gandra PG, Hogan MC. Ca²?-pumping impairment during repetitive fatiguing contractions in single myofibers: role of cross-bridge cycling. Am J Physiol Regul Integr Comp Physiol. 2013 Jul 15; 305(2):R118-25. PMID: 23678027; PMCID: PMC3726998.
    14. Zuo L, Shiah A, Roberts WJ, Chien MT, Wagner PD, Hogan MC. Low Po2 conditions induce reactive oxygen species formation during contractions in single skeletal muscle fibers. Am J Physiol Regul Integr Comp Physiol. 2013 Jun 01; 304(11):R1009-16. PMID: 23576612; PMCID: PMC3680753.
    15. Ramirez-Sanchez I, Nogueira L, Moreno A, Murphy A, Taub P, Perkins G, Ceballos GM, Hogan M, Malek M, Villarreal F. Stimulatory effects of the flavanol (-)-epicatechin on cardiac angiogenesis: additive effects with exercise. J Cardiovasc Pharmacol. 2012 Nov; 60(5):429-38. PMID: 22833114; PMCID: PMC3496054.
    16. Gandra PG, Nogueira L, Hogan MC. Mitochondrial activation at the onset of contractions in isolated myofibres during successive contractile periods. J Physiol. 2012 Aug 01; 590(15):3597-609. PMID: 22711953; PMCID: PMC3547273.
    17. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Perkins G, Murphy AN, Naviaux R, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa. Clin Transl Sci. 2012 Feb; 5(1):43-7. PMID: 22376256.
      View in: PubMed
    18. Nogueira L, Ramirez-Sanchez I, Perkins GA, Murphy A, Taub PR, Ceballos G, Villarreal FJ, Hogan MC, Malek MH. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15; 589(Pt 18):4615-31. PMID: 21788351; PMCID: PMC3208228.
    19. Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE, Olfert IM, McCurdy CE, Marcotte GR, Hogan MC, Baar K, Schenk S. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem. 2011 Sep 02; 286(35):30561-70. PMID: 21757760; PMCID: PMC3162416.
    20. Zuo L, Nogueira L, Hogan MC. Reactive oxygen species formation during tetanic contractions in single isolated Xenopus myofibers. J Appl Physiol (1985). 2011 Sep; 111(3):898-904. PMID: 21700897; PMCID: PMC3174785.
    21. Zuo L, Nogueira L, Hogan MC. Effect of pulmonary TNF-a overexpression on mouse isolated skeletal muscle function. Am J Physiol Regul Integr Comp Physiol. 2011 Oct; 301(4):R1025-31. PMID: 21697519; PMCID: PMC3197448.
    22. Wüst RC, Grassi B, Hogan MC, Howlett RA, Gladden LB, Rossiter HB. Kinetic control of oxygen consumption during contractions in self-perfused skeletal muscle. J Physiol. 2011 Aug 15; 589(Pt 16):3995-4009. PMID: 21690197; PMCID: PMC3179998.
    23. Grassi B, Rossiter HB, Hogan MC, Howlett RA, Harris JE, Goodwin ML, Dobson JL, Gladden LB. Faster O2 uptake kinetics in canine skeletal muscle in situ after acute creatine kinase inhibition. J Physiol. 2011 Jan 01; 589(Pt 1):221-33. PMID: 21059760; PMCID: PMC3039271.
    24. Nogueira L, Hogan MC. Phenol increases intracellular [Ca2+] during twitch contractions in intact Xenopus skeletal myofibers. J Appl Physiol (1985). 2010 Nov; 109(5):1384-93. PMID: 20724558; PMCID: PMC2980372.
    25. Hepple RT, Howlett RA, Kindig CA, Stary CM, Hogan MC. The O2 cost of the tension-time integral in isolated single myocytes during fatigue. Am J Physiol Regul Integr Comp Physiol. 2010 Apr; 298(4):R983-8. PMID: 20130224; PMCID: PMC2853400.
    26. Rosser JI, Walsh B, Hogan MC. Effect of physiological levels of caffeine on Ca2+ handling and fatigue development in Xenopus isolated single myofibers. Am J Physiol Regul Integr Comp Physiol. 2009 May; 296(5):R1512-7. PMID: 19261915; PMCID: PMC2689837.
    27. Stary CM, Walsh BJ, Knapp AE, Brafman D, Hogan MC. Elevation in heat shock protein 72 mRNA following contractions in isolated single skeletal muscle fibers. Am J Physiol Regul Integr Comp Physiol. 2008 Aug; 295(2):R642-8. PMID: 18525012; PMCID: PMC2519928.
    28. Walsh B, Stary CM, Howlett RA, Kelley KM, Hogan MC. Glycolytic activation at the onset of contractions in isolated Xenopus laevis single myofibres. Exp Physiol. 2008 Sep; 93(9):1076-84. PMID: 18515473; PMCID: PMC2862653.
    29. Zoladz JA, Gladden LB, Hogan MC, Nieckarz Z, Grassi B. Progressive recruitment of muscle fibers is not necessary for the slow component of VO2 kinetics. J Appl Physiol (1985). 2008 Aug; 105(2):575-80. PMID: 18483168.
      View in: PubMed
    30. Howlett RA, Hogan MC. Effect of hypoxia on fatigue development in rat muscle composed of different fibre types. Exp Physiol. 2007 Sep; 92(5):887-94. PMID: 17545215.
      View in: PubMed
    31. Howlett RA, Kindig CA, Hogan MC. Intracellular PO2 kinetics at different contraction frequencies in Xenopus single skeletal muscle fibers. J Appl Physiol (1985). 2007 Apr; 102(4):1456-61. PMID: 17204578.
      View in: PubMed
    32. Hogan MC. Vascular NO availability is an important determinant of impaired skeletal muscle microvascular PO in chronic heart failure. Acta Physiol (Oxf). 2006 Sep; 188(1):1. PMID: 16911247.
      View in: PubMed
    33. Gladden LB, Hogan MC. Lactic acid accumulation is an advantage/disadvantage during muscle activity. J Appl Physiol (1985). 2006 Jun; 100(6):2100-1. PMID: 16767812.
      View in: PubMed
    34. Walsh B, Howlett RA, Stary CM, Kindig CA, Hogan MC. Determinants of oxidative phosphorylation onset kinetics in isolated myocytes. Med Sci Sports Exerc. 2005 Sep; 37(9):1551-8. PMID: 16177608.
      View in: PubMed
    35. Howlett RA, Kelley KM, Grassi B, Gladden LB, Hogan MC. Caffeine administration results in greater tension development in previously fatigued canine muscle in situ. Exp Physiol. 2005 Nov; 90(6):873-9. PMID: 16118234.
      View in: PubMed
    36. Grassi B, Hogan MC, Kelley KM, Howlett RA, Gladden LB. Effects of nitric oxide synthase inhibition by L-NAME on oxygen uptake kinetics in isolated canine muscle in situ. J Physiol. 2005 Nov 01; 568(Pt 3):1021-33. PMID: 16081490; PMCID: PMC1464191.
    37. Kindig CA, Walsh B, Howlett RA, Stary CM, Hogan MC. Relationship between intracellular PO2 recovery kinetics and fatigability in isolated single frog myocytes. J Appl Physiol (1985). 2005 Jun; 98(6):2316-9. PMID: 15691906.
      View in: PubMed
    38. Kindig CA, Howlett RA, Hogan MC. Effect of contractile duration on intracellular PO2 kinetics in Xenopus single skeletal myocytes. J Appl Physiol (1985). 2005 May; 98(5):1639-45. PMID: 15649873.
      View in: PubMed
    39. Hogan MC, Stary CM, Balaban RS, Combs CA. NAD(P)H fluorescence imaging of mitochondrial metabolism in contracting Xenopus skeletal muscle fibers: effect of oxygen availability. J Appl Physiol (1985). 2005 Apr; 98(4):1420-6. PMID: 15591295.
      View in: PubMed
    40. Kindig CA, Stary CM, Hogan MC. Effect of dissociating cytosolic calcium and metabolic rate on intracellular PO2 kinetics in single frog myocytes. J Physiol. 2005 Jan 15; 562(Pt 2):527-34. PMID: 15550463; PMCID: PMC1665515.
    41. Kindig CA, Howlett RA, Stary CM, Walsh B, Hogan MC. Effects of acute creatine kinase inhibition on metabolism and tension development in isolated single myocytes. J Appl Physiol (1985). 2005 Feb; 98(2):541-9. PMID: 15333609.
      View in: PubMed
    42. Mason SD, Howlett RA, Kim MJ, Olfert IM, Hogan MC, McNulty W, Hickey RP, Wagner PD, Kahn CR, Giordano FJ, Johnson RS. Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol. 2004 Oct; 2(10):e288. PMID: 15328538; PMCID: PMC514537.
    43. Stary CM, Mathieu-Costello O, Hogan MC. Resistance to fatigue of individual Xenopus single skeletal muscle fibres is correlated with mitochondrial volume density. Exp Physiol. 2004 Sep; 89(5):617-21. PMID: 15258122.
      View in: PubMed
    44. Haseler LJ, Kindig CA, Richardson RS, Hogan MC. The role of oxygen in determining phosphocreatine onset kinetics in exercising humans. J Physiol. 2004 Aug 01; 558(Pt 3):985-92. PMID: 15169844; PMCID: PMC1665010.
    45. Hogan MC, Grassi B, Samaja M, Stary CM, Gladden LB. Effect of contraction frequency on the contractile and noncontractile phases of muscle venous blood flow. J Appl Physiol (1985). 2003 Sep; 95(3):1139-44. PMID: 12794032.
      View in: PubMed
    46. Hepple RT, Stary CM, Kohin S, Wagner PD, Hogan MC. No effect of trans sodium crocetinate on maximal O(2) conductance or V(O(2),max) in moderate hypoxia. Respir Physiol Neurobiol. 2003 Mar 28; 134(3):239-46. PMID: 12660103.
      View in: PubMed
    47. Kindig CA, Howlett RA, Hogan MC. Effect of extracellular PO2 on the fall in intracellular PO2 in contracting single myocytes. J Appl Physiol (1985). 2003 May; 94(5):1964-70. PMID: 12533498.
      View in: PubMed
    48. Howlett RA, Hogan MC. Dichloroacetate accelerates the fall in intracellular PO2 at onset of contractions in Xenopus single muscle fibers. Am J Physiol Regul Integr Comp Physiol. 2003 Feb; 284(2):R481-5. PMID: 12446276.
      View in: PubMed
    49. Kindig CA, Kelley KM, Howlett RA, Stary CM, Hogan MC. Assessment of O2 uptake dynamics in isolated single skeletal myocytes. J Appl Physiol (1985). 2003 Jan; 94(1):353-7. PMID: 12391049.
      View in: PubMed
    50. Grassi B, Hogan MC, Greenhaff PL, Hamann JJ, Kelley KM, Aschenbach WG, Constantin-Teodosiu D, Gladden LB. Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. J Physiol. 2002 Jan 01; 538(Pt 1):195-207. PMID: 11773328; PMCID: PMC2290023.
    51. Hogan MC. Fall in intracellular PO(2) at the onset of contractions in Xenopus single skeletal muscle fibers. J Appl Physiol (1985). 2001 May; 90(5):1871-6. PMID: 11299280.
      View in: PubMed
    52. Hogan MC, Kohin S, Stary CM, Hepple RT. Rapid force recovery in contracting skeletal muscle after brief ischemia is dependent on O(2) availability. J Appl Physiol (1985). 1999 Dec; 87(6):2225-9. PMID: 10601171.
      View in: PubMed
    53. Hogan MC, Richardson RS, Haseler LJ. Human muscle performance and PCr hydrolysis with varied inspired oxygen fractions: a 31P-MRS study. J Appl Physiol (1985). 1999 Apr; 86(4):1367-73. PMID: 10194224.
      View in: PubMed
    54. Hogan MC. Phosphorescence quenching method for measurement of intracellular PO2 in isolated skeletal muscle fibers. J Appl Physiol (1985). 1999 Feb; 86(2):720-4. PMID: 9931213.
      View in: PubMed
    55. Hogan MC, Gladden LB, Grassi B, Stary CM, Samaja M. Bioenergetics of contracting skeletal muscle after partial reduction of blood flow. J Appl Physiol (1985). 1998 Jun; 84(6):1882-8. PMID: 9609780.
      View in: PubMed