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    Michael Hogan

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0623-A
    CA La Jolla 92093
    Phone858-534-2773
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      Collapse Research 
      Collapse Research Activities and Funding
      Assessing and Alleviating Skeletal Muscle Ca2+ Handling Dysfunction in Sarcopenia
      NIH/NIAMS R01AR069577Mar 10, 2017 - Dec 31, 2021
      Role: Principal Investigator
      Assessing and Alleviating Ca2+ Handling Dysfunction in Sarcopenia
      NIH/NIA R56AG047929Sep 1, 2015 - Aug 31, 2016
      Role: Principal Investigator
      Mechanisms of Adaptation to Exercise in Health and COPD
      NIH/NHLBI P01HL091830Dec 8, 2008 - Nov 30, 2014
      Role: Co-Investigator
      Oxygen dependence of ROS generation in contracting single isolated myofibers
      NIH/NIAMS R01AR040155Sep 30, 1991 - Mar 31, 2014
      Role: Principal Investigator
      DETERMINANTS OF MUSCLE MAXIMAL O2 UPTAKE AND PERFORMANCE
      NIH/NIAMS R29AR040155Sep 30, 1991 - Aug 31, 1996
      Role: Principal Investigator
      PHYSIOLOGICAL CONSEQUENCES OF PULMONARY DISEASE
      NIH/NHLBI P01HL017731Feb 1, 1975 - Apr 30, 2006
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Kent JA, Ørtenblad N, Hogan M, Poole DC, Musch TI. No Muscle Is an Island: Integrative Perspectives on Muscle Fatigue. Med Sci Sports Exerc. 2016 Nov; 48(11):2281-2293. PMID: 27434080.
        View in: PubMed
      2. Stary CM, Hogan M. Cytosolic calcium transients are a determinant of contraction-induced HSP72 transcription in single skeletal muscle fibers. J Appl Physiol (1985). 2016 May 15; 120(10):1260-6. PMID: 26869714.
        View in: PubMed
      3. Moreno-Ulloa A, Nogueira L, Rodriguez A, Barboza J, Hogan M, Ceballos G, Villarreal F, Ramirez-Sanchez I. Recovery of Indicators of Mitochondrial Biogenesis, Oxidative Stress, and Aging With (-)-Epicatechin in Senile Mice. J Gerontol A Biol Sci Med Sci. 2015 Nov; 70(11):1370-8. PMID: 25143004.
        View in: PubMed
      4. Delavar H, Nogueira L, Wagner PD, Hogan M, Metzger D, Breen EC. Skeletal myofiber VEGF is essential for the exercise training response in adult mice. Am J Physiol Regul Integr Comp Physiol. 2014 Apr; 306(8):R586-95. PMID: 24523345.
        View in: PubMed
      5. Zuo L, Hallman AH, Roberts WJ, Wagner PD, Hogan M. Superoxide release from contracting skeletal muscle in pulmonary TNF-a overexpression mice. Am J Physiol Regul Integr Comp Physiol. 2014 Jan; 306(1):R75-81. PMID: 24196666.
        View in: PubMed
      6. Nogueira L, Shiah AA, Gandra PG, Hogan M. Ca²?-pumping impairment during repetitive fatiguing contractions in single myofibers: role of cross-bridge cycling. Am J Physiol Regul Integr Comp Physiol. 2013 Jul 15; 305(2):R118-25. PMID: 23678027.
        View in: PubMed
      7. Zuo L, Shiah A, Roberts WJ, Chien MT, Wagner PD, Hogan M. Low Po2 conditions induce reactive oxygen species formation during contractions in single skeletal muscle fibers. Am J Physiol Regul Integr Comp Physiol. 2013 Jun 1; 304(11):R1009-16. PMID: 23576612.
        View in: PubMed
      8. Gandra PG, Nogueira L, Hogan M. Mitochondrial activation at the onset of contractions in isolated myofibres during successive contractile periods. J Physiol. 2012 Aug 1; 590(Pt 15):3597-609. PMID: 22711953.
        View in: PubMed
      9. Nogueira L, Ramirez-Sanchez I, Perkins GA, Murphy A, Taub PR, Ceballos G, Villarreal FJ, Hogan M, Malek MH. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15; 589(Pt 18):4615-31. PMID: 21788351.
        View in: PubMed
      10. Zuo L, Nogueira L, Hogan M. Reactive oxygen species formation during tetanic contractions in single isolated Xenopus myofibers. J Appl Physiol (1985). 2011 Sep; 111(3):898-904. PMID: 21700897.
        View in: PubMed
      11. Zuo L, Nogueira L, Hogan M. Effect of pulmonary TNF-a overexpression on mouse isolated skeletal muscle function. Am J Physiol Regul Integr Comp Physiol. 2011 Oct; 301(4):R1025-31. PMID: 21697519.
        View in: PubMed
      12. Wüst RC, Grassi B, Hogan M, Howlett RA, Gladden LB, Rossiter HB. Kinetic control of oxygen consumption during contractions in self-perfused skeletal muscle. J Physiol. 2011 Aug 15; 589(Pt 16):3995-4009. PMID: 21690197.
        View in: PubMed
      13. Grassi B, Rossiter HB, Hogan M, Howlett RA, Harris JE, Goodwin ML, Dobson JL, Gladden LB. Faster O2 uptake kinetics in canine skeletal muscle in situ after acute creatine kinase inhibition. J Physiol. 2011 Jan 1; 589(Pt 1):221-33. PMID: 21059760.
        View in: PubMed
      14. Nogueira L, Hogan M. Phenol increases intracellular [Ca2+] during twitch contractions in intact Xenopus skeletal myofibers. J Appl Physiol (1985). 2010 Nov; 109(5):1384-93. PMID: 20724558.
        View in: PubMed
      15. Hepple RT, Howlett RA, Kindig CA, Stary CM, Hogan M. The O2 cost of the tension-time integral in isolated single myocytes during fatigue. Am J Physiol Regul Integr Comp Physiol. 2010 Apr; 298(4):R983-8. PMID: 20130224.
        View in: PubMed
      16. Rosser JI, Walsh B, Hogan M. Effect of physiological levels of caffeine on Ca2+ handling and fatigue development in Xenopus isolated single myofibers. Am J Physiol Regul Integr Comp Physiol. 2009 May; 296(5):R1512-7. PMID: 19261915.
        View in: PubMed
      17. Stary CM, Walsh BJ, Knapp AE, Brafman D, Hogan M. Elevation in heat shock protein 72 mRNA following contractions in isolated single skeletal muscle fibers. Am J Physiol Regul Integr Comp Physiol. 2008 Aug; 295(2):R642-8. PMID: 18525012.
        View in: PubMed
      18. Walsh B, Stary CM, Howlett RA, Kelley KM, Hogan M. Glycolytic activation at the onset of contractions in isolated Xenopus laevis single myofibres. Exp Physiol. 2008 Sep; 93(9):1076-84. PMID: 18515473.
        View in: PubMed
      19. Zoladz JA, Gladden LB, Hogan M, Nieckarz Z, Grassi B. Progressive recruitment of muscle fibers is not necessary for the slow component of VO2 kinetics. J Appl Physiol (1985). 2008 Aug; 105(2):575-80. PMID: 18483168.
        View in: PubMed
      20. Howlett RA, Hogan M. Effect of hypoxia on fatigue development in rat muscle composed of different fibre types. Exp Physiol. 2007 Sep; 92(5):887-94. PMID: 17545215.
        View in: PubMed
      21. Howlett RA, Kindig CA, Hogan M. Intracellular PO2 kinetics at different contraction frequencies in Xenopus single skeletal muscle fibers. J Appl Physiol (1985). 2007 Apr; 102(4):1456-61. PMID: 17204578.
        View in: PubMed
      22. Hogan M. Vascular NO availability is an important determinant of impaired skeletal muscle microvascular PO in chronic heart failure. Acta Physiol (Oxf). 2006 Sep; 188(1):1. PMID: 16911247.
        View in: PubMed
      23. Gladden LB, Hogan M. Lactic acid accumulation is an advantage/disadvantage during muscle activity. J Appl Physiol (1985). 2006 Jun; 100(6):2100-1. PMID: 16767812.
        View in: PubMed
      24. Walsh B, Howlett RA, Stary CM, Kindig CA, Hogan M. Determinants of oxidative phosphorylation onset kinetics in isolated myocytes. Med Sci Sports Exerc. 2005 Sep; 37(9):1551-8. PMID: 16177608.
        View in: PubMed
      25. Howlett RA, Kelley KM, Grassi B, Gladden LB, Hogan M. Caffeine administration results in greater tension development in previously fatigued canine muscle in situ. Exp Physiol. 2005 Nov; 90(6):873-9. PMID: 16118234.
        View in: PubMed
      26. Grassi B, Hogan M, Kelley KM, Howlett RA, Gladden LB. Effects of nitric oxide synthase inhibition by L-NAME on oxygen uptake kinetics in isolated canine muscle in situ. J Physiol. 2005 Nov 1; 568(Pt 3):1021-33. PMID: 16081490.
        View in: PubMed
      27. Kindig CA, Walsh B, Howlett RA, Stary CM, Hogan M. Relationship between intracellular PO2 recovery kinetics and fatigability in isolated single frog myocytes. J Appl Physiol (1985). 2005 Jun; 98(6):2316-9. PMID: 15691906.
        View in: PubMed
      28. Kindig CA, Howlett RA, Hogan M. Effect of contractile duration on intracellular PO2 kinetics in Xenopus single skeletal myocytes. J Appl Physiol (1985). 2005 May; 98(5):1639-45. PMID: 15649873.
        View in: PubMed
      29. Hogan M, Stary CM, Balaban RS, Combs CA. NAD(P)H fluorescence imaging of mitochondrial metabolism in contracting Xenopus skeletal muscle fibers: effect of oxygen availability. J Appl Physiol (1985). 2005 Apr; 98(4):1420-6. PMID: 15591295.
        View in: PubMed
      30. Kindig CA, Stary CM, Hogan M. Effect of dissociating cytosolic calcium and metabolic rate on intracellular PO2 kinetics in single frog myocytes. J Physiol. 2005 Jan 15; 562(Pt 2):527-34. PMID: 15550463.
        View in: PubMed
      31. Kindig CA, Howlett RA, Stary CM, Walsh B, Hogan M. Effects of acute creatine kinase inhibition on metabolism and tension development in isolated single myocytes. J Appl Physiol (1985). 2005 Feb; 98(2):541-9. PMID: 15333609.
        View in: PubMed
      32. Mason SD, Howlett RA, Kim MJ, Olfert IM, Hogan M, McNulty W, Hickey RP, Wagner PD, Kahn CR, Giordano FJ, Johnson RS. Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol. 2004 Oct; 2(10):e288. PMID: 15328538.
        View in: PubMed
      33. Stary CM, Mathieu-Costello O, Hogan M. Resistance to fatigue of individual Xenopus single skeletal muscle fibres is correlated with mitochondrial volume density. Exp Physiol. 2004 Sep; 89(5):617-21. PMID: 15258122.
        View in: PubMed
      34. Haseler LJ, Kindig CA, Richardson RS, Hogan M. The role of oxygen in determining phosphocreatine onset kinetics in exercising humans. J Physiol. 2004 Aug 1; 558(Pt 3):985-92. PMID: 15169844.
        View in: PubMed
      35. Hogan M, Grassi B, Samaja M, Stary CM, Gladden LB. Effect of contraction frequency on the contractile and noncontractile phases of muscle venous blood flow. J Appl Physiol (1985). 2003 Sep; 95(3):1139-44. PMID: 12794032.
        View in: PubMed
      36. Hepple RT, Stary CM, Kohin S, Wagner PD, Hogan M. No effect of trans sodium crocetinate on maximal O(2) conductance or V(O(2),max) in moderate hypoxia. Respir Physiol Neurobiol. 2003 Mar 28; 134(3):239-46. PMID: 12660103.
        View in: PubMed
      37. Kindig CA, Howlett RA, Hogan M. Effect of extracellular PO2 on the fall in intracellular PO2 in contracting single myocytes. J Appl Physiol (1985). 2003 May; 94(5):1964-70. PMID: 12533498.
        View in: PubMed
      38. Howlett RA, Hogan M. Dichloroacetate accelerates the fall in intracellular PO2 at onset of contractions in Xenopus single muscle fibers. Am J Physiol Regul Integr Comp Physiol. 2003 Feb; 284(2):R481-5. PMID: 12446276.
        View in: PubMed
      39. Kindig CA, Kelley KM, Howlett RA, Stary CM, Hogan M. Assessment of O2 uptake dynamics in isolated single skeletal myocytes. J Appl Physiol (1985). 2003 Jan; 94(1):353-7. PMID: 12391049.
        View in: PubMed
      40. Grassi B, Hogan M, Greenhaff PL, Hamann JJ, Kelley KM, Aschenbach WG, Constantin-Teodosiu D, Gladden LB. Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. J Physiol. 2002 Jan 1; 538(Pt 1):195-207. PMID: 11773328.
        View in: PubMed
      41. Hogan M. Fall in intracellular PO(2) at the onset of contractions in Xenopus single skeletal muscle fibers. J Appl Physiol (1985). 2001 May; 90(5):1871-6. PMID: 11299280.
        View in: PubMed
      42. Hogan M, Kohin S, Stary CM, Hepple RT. Rapid force recovery in contracting skeletal muscle after brief ischemia is dependent on O(2) availability. J Appl Physiol (1985). 1999 Dec; 87(6):2225-9. PMID: 10601171.
        View in: PubMed
      43. Hogan M, Richardson RS, Haseler LJ. Human muscle performance and PCr hydrolysis with varied inspired oxygen fractions: a 31P-MRS study. J Appl Physiol (1985). 1999 Apr; 86(4):1367-73. PMID: 10194224.
        View in: PubMed
      44. Hogan M. Phosphorescence quenching method for measurement of intracellular PO2 in isolated skeletal muscle fibers. J Appl Physiol (1985). 1999 Feb; 86(2):720-4. PMID: 9931213.
        View in: PubMed
      45. Hogan M, Gladden LB, Grassi B, Stary CM, Samaja M. Bioenergetics of contracting skeletal muscle after partial reduction of blood flow. J Appl Physiol (1985). 1998 Jun; 84(6):1882-8. PMID: 9609780.
        View in: PubMed