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Fred Levine

Title(s)Senate Emeritus, Pediatrics
SchoolHealth Sciences
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    Collapse Research 
    Collapse Research Activities and Funding
    High-Throughput Screen for Beta-Cell Replication
    NIH/NINDS R21NS057001Sep 5, 2006 - Aug 31, 2008
    Role: Principal Investigator
    Small Molecular Regulation of Beta-Cell Differentiation
    NIH/NIDDK R01DK068754Jul 1, 2004 - Jun 30, 2006
    Role: Principal Investigator
    Growth Versus Differentiation in Human Beta Cells
    NIH/NIDDK R01DK055283Sep 30, 1998 - Mar 31, 2010
    Role: Principal Investigator
    INHIBITION OF APOPTOSIS IN PANCREATIC BETA CELLS
    NIH/NIDDK R01DK055065Sep 30, 1998 - Sep 29, 2002
    Role: Principal Investigator
    PANCREATIC CELL LINES--DEVELOPMENT AND CHARACTERIZATION
    NIH/NIDDK R55DK050171Sep 1, 1995 - Aug 31, 1997
    Role: Principal Investigator
    GENE EXPRESSION FROM RETROVIRAL VECTORS AND GENE THERAPY
    NIH/NIGMS F32GM013538Jan 19, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lee SH, Hao E, Scharp D, Levine F. Insulin acts as a repressive factor to inhibit the ability of PAR2 to induce islet cell transdifferentiation. Islets. 2018 May 03; 1-12. PMID: 29723131.
      View in: PubMed
    2. Lee SH, Cunha D, Piermarocchi C, Paternostro G, Pinkerton A, Ladriere L, Marchetti P, Eizirik DL, Cnop M, Levine F. High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced ß-cell apoptosis. Biochem Pharmacol. 2017 08 15; 138:140-149. PMID: 28522407.
      View in: PubMed
    3. Piran R, Lee SH, Kuss P, Hao E, Newlin R, Millán JL, Levine F. PAR2 regulates regeneration, transdifferentiation, and death. Cell Death Dis. 2016 11 03; 7(11):e2452. PMID: 27809303.
      View in: PubMed
    4. Chung CH, Miller A, Panopoulos A, Hao E, Margolis R, Terskikh A, Levine F. Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not ß-cell, regeneration. Physiol Rep. 2014 Sep 01; 2(9). PMID: 25194022.
      View in: PubMed
    5. Lee SH, Piran R, Keinan E, Pinkerton A, Levine F. Induction of ß-cell replication by a synthetic HNF4a antagonist. Stem Cells. 2013 Nov; 31(11):2396-407. PMID: 23922283.
      View in: PubMed
    6. Hao E, Lee SH, Levine F. Efficient ß-cell regeneration by a combination of neogenesis and replication following ß-cell ablation and reversal of pancreatic duct ligation. Stem Cells. 2013 Nov; 31(11):2388-95. PMID: 23922239.
      View in: PubMed
    7. Lee SH, Athavankar S, Cohen T, Piran R, Kiselyuk A, Levine F. Identification of alverine and benfluorex as HNF4a activators. ACS Chem Biol. 2013 Aug 16; 8(8):1730-6. PMID: 23675775.
      View in: PubMed
    8. Kiselyuk A, Lee SH, Farber-Katz S, Zhang M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P, Richardson AD, Hostetler HA, Rodriguez-Lee M, Huang L, Spangler B, Smith L, Higginbotham J, Cashman J, Freeze H, Itkin-Ansari P, Dawson MI, Schroeder F, Cang Y, Mercola M, Levine F. HNF4a antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27; 19(7):806-18. PMID: 22840769.
      View in: PubMed
    9. Lee SH, Hao E, Levine F, Itkin-Ansari P. Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic ß-cells. Islets. 2011 Nov-Dec; 3(6):358-66. PMID: 21964314.
      View in: PubMed
    10. Tyrberg B, Miles P, Azizian KT, Denzel MS, Nieves ML, Monosov EZ, Levine F, Ranscht B. T-cadherin (Cdh13) in association with pancreatic ß-cell granules contributes to second phase insulin secretion. Islets. 2011 Nov-Dec; 3(6):327-37. PMID: 21975561.
      View in: PubMed
    11. Lee SH, Hao E, Levine F. ß-Cell replication and islet neogenesis following partial pancreatectomy. Islets. 2011 Jul-Aug; 3(4):188-95. PMID: 21623169.
      View in: PubMed
    12. Lee SH, Hao E, Kiselyuk A, Shapiro J, Shields DJ, Lowy A, Levine F, Itkin-Ansari P. The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma. Mol Cancer Res. 2011 Jun; 9(6):782-90. PMID: 21498546.
      View in: PubMed
    13. Lee SH, Itkin-Ansari P, Levine F. CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells. Aging (Albany NY). 2010 Nov; 2(11):785-90. PMID: 21068465.
      View in: PubMed
    14. Chung CH, Hao E, Piran R, Keinan E, Levine F. Pancreatic ß-cell neogenesis by direct conversion from mature a-cells. Stem Cells. 2010 Sep; 28(9):1630-8. PMID: 20653050.
      View in: PubMed
    15. Chung CH, Levine F. Adult pancreatic alpha-cells: a new source of cells for beta-cell regeneration. Rev Diabet Stud. 2010; 7(2):124-31. PMID: 21060971.
      View in: PubMed
    16. Kiselyuk A, Farber-Katz S, Cohen T, Lee SH, Geron I, Azimi B, Heynen-Genel S, Singer O, Price J, Mercola M, Itkin-Ansari P, Levine F. Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen. J Biomol Screen. 2010 Jul; 15(6):663-70. PMID: 20547533.
      View in: PubMed
    17. Dawson MI, Ye M, Cao X, Farhana L, Hu QY, Zhao Y, Xu LP, Kiselyuk A, Correa RG, Yang L, Hou T, Reed JC, Itkin-Ansari P, Levine F, Sanner MF, Fontana JA, Zhang XK. Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene. ChemMedChem. 2009 Jul; 4(7):1106-19. PMID: 19378296.
      View in: PubMed
    18. Zhang SS, Hao E, Yu J, Liu W, Wang J, Levine F, Feng GS. Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7531-6. PMID: 19380737.
      View in: PubMed
    19. Lee SH, Demeterco C, Geron I, Abrahamsson A, Levine F, Itkin-Ansari P. Islet specific Wnt activation in human type II diabetes. Exp Diabetes Res. 2008; 2008:728763. PMID: 19165345.
      View in: PubMed
    20. Levine F, Itkin-Ansari P. beta-cell Regeneration: neogenesis, replication or both? J Mol Med (Berl). 2008 Mar; 86(3):247-58. PMID: 17922102.
      View in: PubMed
    21. Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F. HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion. Biochem Biophys Res Commun. 2007 Apr 06; 355(2):331-7. PMID: 17300753.
      View in: PubMed
    22. Katkov II, Kim MS, Bajpai R, Altman YS, Mercola M, Loring JF, Terskikh AV, Snyder EY, Levine F. Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells. Cryobiology. 2006 Oct; 53(2):194-205. PMID: 16839540.
      View in: PubMed
    23. Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F. Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas. Nat Med. 2006 Mar; 12(3):310-6. PMID: 16491084.
      View in: PubMed
    24. Ball AJ, Levine F. Telomere-independent cellular senescence in human fetal cardiomyocytes. Aging Cell. 2005 Feb; 4(1):21-30. PMID: 15659210.
      View in: PubMed
    25. Levine F, Mercola M. No pancreatic endocrine stem cells? N Engl J Med. 2004 Sep 02; 351(10):1024-6. PMID: 15342812.
      View in: PubMed
    26. Barshop BA, Naviaux RK, McGowan KA, Levine F, Nyhan WL, Loupis-Geller A, Haas RH. Chronic treatment of mitochondrial disease patients with dichloroacetate. Mol Genet Metab. 2004 Sep-Oct; 83(1-2):138-49. PMID: 15464428.
      View in: PubMed
    27. Katkov II, Levine F. Prediction of the glass transition temperature of water solutions: comparison of different models. Cryobiology. 2004 Aug; 49(1):62-82. PMID: 15265717.
      View in: PubMed
    28. Itkin-Ansari P, Levine F. Sources of beta-cells for human cell-based therapies for diabetes. Cell Biochem Biophys. 2004; 40(3 Suppl):103-12. PMID: 15289647.
      View in: PubMed
    29. Itkin-Ansari P, Geron I, Hao E, Demeterco C, Tyrberg B, Levine F. Cell-based therapies for diabetes: progress towards a transplantable human beta cell line. Ann N Y Acad Sci. 2003 Nov; 1005:138-47. PMID: 14679048.
      View in: PubMed
    30. Demeterco C, Itkin-Ansari P, Tyrberg B, Ford LP, Jarvis RA, Levine F. c-Myc controls proliferation versus differentiation in human pancreatic endocrine cells. J Clin Endocrinol Metab. 2002 Jul; 87(7):3475-85. PMID: 12107268.
      View in: PubMed
    31. Tyrberg B, Anachkov KA, Dib SA, Wang-Rodriguez J, Yoon KH, Levine F. Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes. BMC Endocr Disord. 2002 Apr 25; 2(1):2. PMID: 12003641.
      View in: PubMed
    32. Levine F, Leibowitz G. Towards gene therapy of diabetes mellitus. Mol Med Today. 1999 Apr; 5(4):165-71. PMID: 10203749.
      View in: PubMed