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Fred Levine

Title(s)Recall Faculty, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse research activities and funding
    High-Throughput Screen for Beta-Cell Replication
    NIH R21NS057001Sep 5, 2006 - Aug 31, 2008
    Role: Principal Investigator
    Small Molecular Regulation of Beta-Cell Differentiation
    NIH R01DK068754Jul 1, 2004 - Jun 30, 2006
    Role: Principal Investigator
    Growth Versus Differentiation in Human Beta Cells
    NIH R01DK055283Sep 30, 1998 - Mar 31, 2010
    Role: Principal Investigator
    INHIBITION OF APOPTOSIS IN PANCREATIC BETA CELLS
    NIH R01DK055065Sep 30, 1998 - Sep 29, 2002
    Role: Principal Investigator
    PANCREATIC CELL LINES--DEVELOPMENT AND CHARACTERIZATION
    NIH R55DK050171Sep 1, 1995 - Aug 31, 1997
    Role: Principal Investigator
    GENE EXPRESSION FROM RETROVIRAL VECTORS AND GENE THERAPY
    NIH F32GM013538Jan 19, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Resolving the conflicts around Par2 opposing roles in regeneration by comparing immune-mediated and toxic-induced injuries. Inflamm Regen. 2022 Nov 29; 42(1):52. Reches G, Blondheim Shraga NR, Carrette F, Malka A, Saleev N, Gubbay Y, Ertracht O, Haviv I, Bradley LM, Levine F, Piran R. PMID: 36447218; PMCID: PMC9706915.
      View in: PubMed   Mentions: 7  
    2. A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells. PLoS One. 2022; 17(4):e0266066. Lee SH, Veeriah V, Levine F. PMID: 35385524; PMCID: PMC8985954.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    3. Approaches to Inducing β-Cell Regeneration. Biomedicines. 2022 Feb 28; 10(3). Levine F. PMID: 35327373; PMCID: PMC8945803.
      View in: PubMed   Mentions: 2  
    4. Long-term oral administration of an HNF4α agonist prevents weight gain and hepatic steatosis by promoting increased mitochondrial mass and function. Cell Death Dis. 2022 01 27; 13(1):89. Veeriah V, Lee SH, Levine F. PMID: 35087037; PMCID: PMC8795379.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    5. Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist. Cell Death Dis. 2021 06 11; 12(6):603. Lee SH, Veeriah V, Levine F. PMID: 34117215; PMCID: PMC8193211.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    6. Insulin acts as a repressive factor to inhibit the ability of PAR2 to induce islet cell transdifferentiation. Islets. 2018 09 19; 10(6):201-212. Lee SH, Hao E, Scharp D, Levine F. PMID: 29723131; PMCID: PMC6300087.
      View in: PubMed   Mentions: 4     Fields:    
    7. High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis. Biochem Pharmacol. 2017 08 15; 138:140-149. Lee SH, Cunha D, Piermarocchi C, Paternostro G, Pinkerton A, Ladriere L, Marchetti P, Eizirik DL, Cnop M, Levine F. PMID: 28522407; PMCID: PMC9093020.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    8. PAR2 regulates regeneration, transdifferentiation, and death. Cell Death Dis. 2016 11 03; 7(11):e2452. Piran R, Lee SH, Kuss P, Hao E, Newlin R, Millán JL, Levine F. PMID: 27809303; PMCID: PMC5260873.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    9. Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not β-cell, regeneration. Physiol Rep. 2014 Sep 01; 2(9). Chung CH, Miller A, Panopoulos A, Hao E, Margolis R, Terskikh A, Levine F. PMID: 25194022; PMCID: PMC4270240.
      View in: PubMed   Mentions: 3     Fields:    
    10. Induction of β-cell replication by a synthetic HNF4α antagonist. Stem Cells. 2013 Nov; 31(11):2396-407. Lee SH, Piran R, Keinan E, Pinkerton A, Levine F. PMID: 23922283.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. Efficient β-cell regeneration by a combination of neogenesis and replication following β-cell ablation and reversal of pancreatic duct ligation. Stem Cells. 2013 Nov; 31(11):2388-95. Hao E, Lee SH, Levine F. PMID: 23922239.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    12. Identification of alverine and benfluorex as HNF4α activators. ACS Chem Biol. 2013 Aug 16; 8(8):1730-6. Lee SH, Athavankar S, Cohen T, Piran R, Kiselyuk A, Levine F. PMID: 23675775; PMCID: PMC3922238.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    13. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27; 19(7):806-18. Kiselyuk A, Lee SH, Farber-Katz S, Zhang M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P, Richardson AD, Hostetler HA, Rodriguez-Lee M, Huang L, Spangler B, Smith L, Higginbotham J, Cashman J, Freeze H, Itkin-Ansari P, Dawson MI, Schroeder F, Cang Y, Mercola M, Levine F. PMID: 22840769; PMCID: PMC3447631.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    14. Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cells. Islets. 2011 Nov-Dec; 3(6):358-66. Lee SH, Hao E, Levine F, Itkin-Ansari P. PMID: 21964314; PMCID: PMC3329516.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    15. T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion. Islets. 2011 Nov-Dec; 3(6):327-37. Tyrberg B, Miles P, Azizian KT, Denzel MS, Nieves ML, Monosov EZ, Levine F, Ranscht B. PMID: 21975561; PMCID: PMC3329514.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    16. β-Cell replication and islet neogenesis following partial pancreatectomy. Islets. 2011 Jul-Aug; 3(4):188-95. Lee SH, Hao E, Levine F. PMID: 21623169.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    17. The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma. Mol Cancer Res. 2011 Jun; 9(6):782-90. Lee SH, Hao E, Kiselyuk A, Shapiro J, Shields DJ, Lowy A, Levine F, Itkin-Ansari P. PMID: 21498546; PMCID: PMC3954712.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    18. CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells. Aging (Albany NY). 2010 Nov; 2(11):785-90. Lee SH, Itkin-Ansari P, Levine F. PMID: 21068465; PMCID: PMC3006021.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    19. Pancreatic β-cell neogenesis by direct conversion from mature α-cells. Stem Cells. 2010 Sep; 28(9):1630-8. Chung CH, Hao E, Piran R, Keinan E, Levine F. PMID: 20653050.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    20. Adult pancreatic alpha-cells: a new source of cells for beta-cell regeneration. Rev Diabet Stud. 2010; 7(2):124-31. Chung CH, Levine F. PMID: 21060971; PMCID: PMC2989785.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    21. Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen. J Biomol Screen. 2010 Jul; 15(6):663-70. Kiselyuk A, Farber-Katz S, Cohen T, Lee SH, Geron I, Azimi B, Heynen-Genel S, Singer O, Price J, Mercola M, Itkin-Ansari P, Levine F. PMID: 20547533; PMCID: PMC3374493.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    22. Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene. ChemMedChem. 2009 Jul; 4(7):1106-19. Dawson MI, Ye M, Cao X, Farhana L, Hu QY, Zhao Y, Xu LP, Kiselyuk A, Correa RG, Yang L, Hou T, Reed JC, Itkin-Ansari P, Levine F, Sanner MF, Fontana JA, Zhang XK. PMID: 19378296; PMCID: PMC3031428.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    23. Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7531-6. Zhang SS, Hao E, Yu J, Liu W, Wang J, Levine F, Feng GS. PMID: 19380737; PMCID: PMC2678606.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    24. Islet specific Wnt activation in human type II diabetes. Exp Diabetes Res. 2008; 2008:728763. Lee SH, Demeterco C, Geron I, Abrahamsson A, Levine F, Itkin-Ansari P. PMID: 19165345; PMCID: PMC2628766.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    25. beta-cell Regeneration: neogenesis, replication or both? J Mol Med (Berl). 2008 Mar; 86(3):247-58. Levine F, Itkin-Ansari P. PMID: 17922102.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    26. HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion. Biochem Biophys Res Commun. 2007 Apr 06; 355(2):331-7. Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F. PMID: 17300753; PMCID: PMC1852427.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    27. Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells. Cryobiology. 2006 Oct; 53(2):194-205. Katkov II, Kim MS, Bajpai R, Altman YS, Mercola M, Loring JF, Terskikh AV, Snyder EY, Levine F. PMID: 16839540.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    28. Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas. Nat Med. 2006 Mar; 12(3):310-6. Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F. PMID: 16491084.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    29. Telomere-independent cellular senescence in human fetal cardiomyocytes. Aging Cell. 2005 Feb; 4(1):21-30. Ball AJ, Levine F. PMID: 15659210.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    30. No pancreatic endocrine stem cells? N Engl J Med. 2004 Sep 02; 351(10):1024-6. Levine F, Mercola M. PMID: 15342812.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    31. Chronic treatment of mitochondrial disease patients with dichloroacetate. Mol Genet Metab. 2004 Sep-Oct; 83(1-2):138-49. Barshop BA, Naviaux RK, McGowan KA, Levine F, Nyhan WL, Loupis-Geller A, Haas RH. PMID: 15464428.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCTClinical Trials
    32. Prediction of the glass transition temperature of water solutions: comparison of different models. Cryobiology. 2004 Aug; 49(1):62-82. Katkov II, Levine F. PMID: 15265717.
      View in: PubMed   Mentions: 11     Fields:    
    33. Sources of beta-cells for human cell-based therapies for diabetes. Cell Biochem Biophys. 2004; 40(3 Suppl):103-12. Itkin-Ansari P, Levine F. PMID: 15289647.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    34. Cell-based therapies for diabetes: progress towards a transplantable human beta cell line. Ann N Y Acad Sci. 2003 Nov; 1005:138-47. Itkin-Ansari P, Geron I, Hao E, Demeterco C, Tyrberg B, Levine F. PMID: 14679048.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    35. c-Myc controls proliferation versus differentiation in human pancreatic endocrine cells. J Clin Endocrinol Metab. 2002 Jul; 87(7):3475-85. Demeterco C, Itkin-Ansari P, Tyrberg B, Ford LP, Jarvis RA, Levine F. PMID: 12107268.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    36. Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes. BMC Endocr Disord. 2002 Apr 25; 2(1):2. Tyrberg B, Anachkov KA, Dib SA, Wang-Rodriguez J, Yoon KH, Levine F. PMID: 12003641; PMCID: PMC111186.
      View in: PubMed   Mentions: 16     Fields:    
    37. Towards gene therapy of diabetes mellitus. Mol Med Today. 1999 Apr; 5(4):165-71. Levine F, Leibowitz G. PMID: 10203749.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
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