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Fred Levine

TitleSenate Emeritus
InstitutionUniversity of California San Diego
DepartmentPediatrics
Address9500 Gilman Drive #0816
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    High-Throughput Screen for Beta-Cell Replication
    NIH/NINDS R21NS057001Sep 5, 2006 - Aug 31, 2008
    Role: Principal Investigator
    Small Molecular Regulation of Beta-Cell Differentiation
    NIH/NIDDK R01DK068754Jul 1, 2004 - Jun 30, 2006
    Role: Principal Investigator
    Growth Versus Differentiation in Human Beta Cells
    NIH/NIDDK R01DK055283Sep 30, 1998 - Mar 31, 2010
    Role: Principal Investigator
    INHIBITION OF APOPTOSIS IN PANCREATIC BETA CELLS
    NIH/NIDDK R01DK055065Sep 30, 1998 - Sep 29, 2002
    Role: Principal Investigator
    PANCREATIC CELL LINES--DEVELOPMENT AND CHARACTERIZATION
    NIH/NIDDK R55DK050171Sep 1, 1995 - Aug 31, 1997
    Role: Principal Investigator
    GENE EXPRESSION FROM RETROVIRAL VECTORS AND GENE THERAPY
    NIH/NIGMS F32GM013538Jan 19, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lee SH, Hao E, Scharp D, Levine F. Insulin Acts as a Repressive Factor to Inhibit the Ability of PAR2 to Induce Islet Cell Transdifferentiation. Islets. 2018 May 03; 1-24. PMID: 29723131.
      View in: PubMed
    2. Lee SH, Cunha D, Piermarocchi C, Paternostro G, Pinkerton A, Ladriere L, Marchetti P, Eizirik DL, Cnop M, Levine F. High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced ß-cell apoptosis. Biochem Pharmacol. 2017 08 15; 138:140-149. PMID: 28522407.
      View in: PubMed
    3. Piran R, Lee SH, Kuss P, Hao E, Newlin R, Millán JL, Levine F. PAR2 regulates regeneration, transdifferentiation, and death. Cell Death Dis. 2016 11 03; 7(11):e2452. PMID: 27809303.
      View in: PubMed
    4. Chung CH, Miller A, Panopoulos A, Hao E, Margolis R, Terskikh A, Levine F. Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not ß-cell, regeneration. Physiol Rep. 2014 Sep 01; 2(9). PMID: 25194022; PMCID: PMC4270240.
    5. Lee SH, Piran R, Keinan E, Pinkerton A, Levine F. Induction of ß-cell replication by a synthetic HNF4a antagonist. Stem Cells. 2013 Nov; 31(11):2396-407. PMID: 23922283.
      View in: PubMed
    6. Hao E, Lee SH, Levine F. Efficient ß-cell regeneration by a combination of neogenesis and replication following ß-cell ablation and reversal of pancreatic duct ligation. Stem Cells. 2013 Nov; 31(11):2388-95. PMID: 23922239.
      View in: PubMed
    7. Lee SH, Athavankar S, Cohen T, Piran R, Kiselyuk A, Levine F. Identification of alverine and benfluorex as HNF4a activators. ACS Chem Biol. 2013 Aug 16; 8(8):1730-6. PMID: 23675775; PMCID: PMC3922238.
    8. Kiselyuk A, Lee SH, Farber-Katz S, Zhang M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P, Richardson AD, Hostetler HA, Rodriguez-Lee M, Huang L, Spangler B, Smith L, Higginbotham J, Cashman J, Freeze H, Itkin-Ansari P, Dawson MI, Schroeder F, Cang Y, Mercola M, Levine F. HNF4a antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27; 19(7):806-18. PMID: 22840769; PMCID: PMC3447631.
    9. Lee SH, Hao E, Levine F, Itkin-Ansari P. Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic ß-cells. Islets. 2011 Nov-Dec; 3(6):358-66. PMID: 21964314; PMCID: PMC3329516.
    10. Tyrberg B, Miles P, Azizian KT, Denzel MS, Nieves ML, Monosov EZ, Levine F, Ranscht B. T-cadherin (Cdh13) in association with pancreatic ß-cell granules contributes to second phase insulin secretion. Islets. 2011 Nov-Dec; 3(6):327-37. PMID: 21975561; PMCID: PMC3329514.
    11. Lee SH, Hao E, Levine F. ß-Cell replication and islet neogenesis following partial pancreatectomy. Islets. 2011 Jul-Aug; 3(4):188-95. PMID: 21623169.
      View in: PubMed
    12. Lee SH, Hao E, Kiselyuk A, Shapiro J, Shields DJ, Lowy A, Levine F, Itkin-Ansari P. The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma. Mol Cancer Res. 2011 Jun; 9(6):782-90. PMID: 21498546; PMCID: PMC3954712.
    13. Lee SH, Itkin-Ansari P, Levine F. CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells. Aging (Albany NY). 2010 Nov; 2(11):785-90. PMID: 21068465; PMCID: PMC3006021.
    14. Chung CH, Hao E, Piran R, Keinan E, Levine F. Pancreatic ß-cell neogenesis by direct conversion from mature a-cells. Stem Cells. 2010 Sep; 28(9):1630-8. PMID: 20653050.
      View in: PubMed
    15. Chung CH, Levine F. Adult pancreatic alpha-cells: a new source of cells for beta-cell regeneration. Rev Diabet Stud. 2010; 7(2):124-31. PMID: 21060971; PMCID: PMC2989785.
    16. Kiselyuk A, Farber-Katz S, Cohen T, Lee SH, Geron I, Azimi B, Heynen-Genel S, Singer O, Price J, Mercola M, Itkin-Ansari P, Levine F. Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen. J Biomol Screen. 2010 Jul; 15(6):663-70. PMID: 20547533; PMCID: PMC3374493.
    17. Dawson MI, Ye M, Cao X, Farhana L, Hu QY, Zhao Y, Xu LP, Kiselyuk A, Correa RG, Yang L, Hou T, Reed JC, Itkin-Ansari P, Levine F, Sanner MF, Fontana JA, Zhang XK. Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene. ChemMedChem. 2009 Jul; 4(7):1106-19. PMID: 19378296; PMCID: PMC3031428.
    18. Zhang SS, Hao E, Yu J, Liu W, Wang J, Levine F, Feng GS. Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7531-6. PMID: 19380737; PMCID: PMC2678606.
    19. Lee SH, Demeterco C, Geron I, Abrahamsson A, Levine F, Itkin-Ansari P. Islet specific Wnt activation in human type II diabetes. Exp Diabetes Res. 2008; 2008:728763. PMID: 19165345; PMCID: PMC2628766.
    20. Levine F, Itkin-Ansari P. beta-cell Regeneration: neogenesis, replication or both? J Mol Med (Berl). 2008 Mar; 86(3):247-58. PMID: 17922102.
      View in: PubMed
    21. Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F. HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion. Biochem Biophys Res Commun. 2007 Apr 06; 355(2):331-7. PMID: 17300753; PMCID: PMC1852427.
    22. Katkov II, Kim MS, Bajpai R, Altman YS, Mercola M, Loring JF, Terskikh AV, Snyder EY, Levine F. Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells. Cryobiology. 2006 Oct; 53(2):194-205. PMID: 16839540.
      View in: PubMed
    23. Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F. Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas. Nat Med. 2006 Mar; 12(3):310-6. PMID: 16491084.
      View in: PubMed
    24. Ball AJ, Levine F. Telomere-independent cellular senescence in human fetal cardiomyocytes. Aging Cell. 2005 Feb; 4(1):21-30. PMID: 15659210.
      View in: PubMed
    25. Levine F, Mercola M. No pancreatic endocrine stem cells? N Engl J Med. 2004 Sep 02; 351(10):1024-6. PMID: 15342812.
      View in: PubMed
    26. Barshop BA, Naviaux RK, McGowan KA, Levine F, Nyhan WL, Loupis-Geller A, Haas RH. Chronic treatment of mitochondrial disease patients with dichloroacetate. Mol Genet Metab. 2004 Sep-Oct; 83(1-2):138-49. PMID: 15464428.
      View in: PubMed
    27. Katkov II, Levine F. Prediction of the glass transition temperature of water solutions: comparison of different models. Cryobiology. 2004 Aug; 49(1):62-82. PMID: 15265717.
      View in: PubMed
    28. Itkin-Ansari P, Levine F. Sources of beta-cells for human cell-based therapies for diabetes. Cell Biochem Biophys. 2004; 40(3 Suppl):103-12. PMID: 15289647.
      View in: PubMed
    29. Itkin-Ansari P, Geron I, Hao E, Demeterco C, Tyrberg B, Levine F. Cell-based therapies for diabetes: progress towards a transplantable human beta cell line. Ann N Y Acad Sci. 2003 Nov; 1005:138-47. PMID: 14679048.
      View in: PubMed
    30. Demeterco C, Itkin-Ansari P, Tyrberg B, Ford LP, Jarvis RA, Levine F. c-Myc controls proliferation versus differentiation in human pancreatic endocrine cells. J Clin Endocrinol Metab. 2002 Jul; 87(7):3475-85. PMID: 12107268.
      View in: PubMed
    31. Tyrberg B, Anachkov KA, Dib SA, Wang-Rodriguez J, Yoon KH, Levine F. Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes. BMC Endocr Disord. 2002 Apr 25; 2(1):2. PMID: 12003641.
      View in: PubMed
    32. Levine F, Leibowitz G. Towards gene therapy of diabetes mellitus. Mol Med Today. 1999 Apr; 5(4):165-71. PMID: 10203749.
      View in: PubMed