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Michael Yaffe

Title(s)Emeritus Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Mechanisms of Mitochondrial Division and Inheritance
    NIH/NIGMS R01GM044614Apr 1, 1993 - Mar 31, 2006
    Role: Principal Investigator
    BIOGENESIS OF THE MITOCHONDRIAL OUTER MEMBRANE
    NIH/NIGMS R01GM035315Jul 1, 1985 - Jun 30, 1988
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Raising the standards of stem cell line quality. Nat Cell Biol. 2016 Mar; 18(3):236-7. Yaffe MP, Noggle SA, Solomon SL. PMID: 26911906.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    2. Building stem-cell genomics in California and beyond. Nat Biotechnol. 2012 Jan 09; 30(1):20-5. Dewitt ND, Yaffe MP, Trounson A. PMID: 22231086.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. Am J Pathol. 2009 Nov; 175(5):1810-6. Area-Gomez E, de Groof AJ, Boldogh I, Bird TD, Gibson GE, Koehler CM, Yu WH, Duff KE, Yaffe MP, Pon LA, Schon EA. PMID: 19834068.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    4. The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry. PLoS Biol. 2008 Aug 19; 6(8):e203. Mazanka E, Alexander J, Yeh BJ, Charoenpong P, Lowery DM, Yaffe M, Weiss EL. PMID: 18715118.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    5. CLASP regulates mitochondrial distribution in Schizosaccharomyces pombe. J Cell Biol. 2008 Jul 14; 182(1):41-9. Chiron S, Bobkova A, Zhou H, Yaffe MP. PMID: 18606849.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. Reactive biomolecular divergence in genetically altered yeast cells and isolated mitochondria as measured by biocavity laser spectroscopy: rapid diagnostic method for studying cellular responses to stress and disease. J Biomed Opt. 2007 Sep-Oct; 12(5):054003. Gourley PL, Hendricks JK, McDonald AE, Copeland RG, Yaffe MP, Naviaux RK. PMID: 17994891.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p. J Cell Biol. 2006 Jun 05; 173(5):651-8. Sesaki H, Dunn CD, Iijima M, Shepard KA, Yaffe MP, Machamer CE, Jensen RE. PMID: 16754953.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    8. The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev Cell. 2004 Jul; 7(1):61-71. Meisinger C, Rissler M, Chacinska A, Szklarz LK, Milenkovic D, Kozjak V, Schönfisch B, Lohaus C, Meyer HE, Yaffe MP, Guiard B, Wiedemann N, Pfanner N. PMID: 15239954.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    9. Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe. Mol Biol Cell. 2004 Apr; 15(4):1656-65. Weir BA, Yaffe MP. PMID: 14767070.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    10. Mitochondrial positioning in fission yeast is driven by association with dynamic microtubules and mitotic spindle poles. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11424-8. Yaffe MP, Stuurman N, Vale RD. PMID: 12972644.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    11. The cutting edge of mitochondrial fusion. Nat Cell Biol. 2003 Jun; 5(6):497-9. Yaffe MP. PMID: 12776123.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell. 2003 Jun; 14(6):2342-56. Sesaki H, Southard SM, Yaffe MP, Jensen RE. PMID: 12808034.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    13. Mitochondrial DNA inheritance in Saccharomyces cerevisiae. Trends Microbiol. 2000 Nov; 8(11):508-13. Berger KH, Yaffe MP. PMID: 11121761.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    14. Gag3p, an outer membrane protein required for fission of mitochondrial tubules. J Cell Biol. 2000 Oct 16; 151(2):333-40. Fekkes P, Shepard KA, Yaffe MP. PMID: 11038180.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    15. Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation. J Biol Chem. 2000 May 26; 275(21):16127-33. Kluck RM, Ellerby LM, Ellerby HM, Naiem S, Yaffe MP, Margoliash E, Bredesen D, Mauk AG, Sherman F, Newmeyer DD. PMID: 10821864.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    16. Dynamic mitochondria. Nat Cell Biol. 1999 Oct; 1(6):E149-50. Yaffe MP. PMID: 10559975.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    17. A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae. J Cell Biol. 1999 Jun 14; 145(6):1199-208. Fisk HA, Yaffe MP. PMID: 10366593.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    18. The machinery of mitochondrial inheritance and behavior. Science. 1999 Mar 05; 283(5407):1493-7. Yaffe MP. PMID: 10066164.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    19. The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance. J Cell Biol. 1999 Feb 22; 144(4):711-20. Shepard KA, Yaffe MP. PMID: 10037792.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    20. Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol. 1998 Jul; 18(7):4043-52. Berger KH, Yaffe MP. PMID: 9632789.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    21. Mitochondrial morphogenesis: fusion factor for fly fertility. Curr Biol. 1997 Dec 01; 7(12):R782-3. Yaffe MP. PMID: 9382824.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    22. Mutational analysis of Mdm1p function in nuclear and mitochondrial inheritance. J Cell Biol. 1997 Aug 11; 138(3):485-94. Fisk HA, Yaffe MP. PMID: 9245780.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    23. Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast. J Cell Biol. 1997 Feb 10; 136(3):545-53. Berger KH, Sogo LF, Yaffe MP. PMID: 9024686.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    24. Mitochondrial distribution and inheritance. Experientia. 1996 Dec 15; 52(12):1111-6. Berger KH, Yaffe MP. PMID: 8988253.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    25. Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells. Mol Cell Biol. 1996 Nov; 16(11):6494-508. Zha H, Fisk HA, Yaffe MP, Mahajan N, Herman B, Reed JC. PMID: 8887678.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    26. Microtubules mediate mitochondrial distribution in fission yeast. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11664-8. Yaffe MP, Harata D, Verde F, Eddison M, Toda T, Nurse P. PMID: 8876193.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    27. BRO1, a novel gene that interacts with components of the Pkc1p-mitogen-activated protein kinase pathway in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Jun; 16(6):2585-93. Nickas ME, Yaffe MP. PMID: 8649366.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    28. Isolation and analysis of mitochondrial inheritance mutants from Saccharomyces cerevisiae. Methods Enzymol. 1995; 260:447-53. Yaffe MP. PMID: 8592466.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    29. Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. J Cell Biol. 1994 Sep; 126(6):1361-73. Sogo LF, Yaffe MP. PMID: 8089171.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    30. Intermediate filament formation by a yeast protein essential for organelle inheritance. Science. 1993 Apr 30; 260(5108):687-9. McConnell SJ, Yaffe MP. PMID: 8480179.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    31. Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein. J Cell Biol. 1992 Jul; 118(2):385-95. McConnell SJ, Yaffe MP. PMID: 1378448.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    32. MAS5, a yeast homolog of DnaJ involved in mitochondrial protein import. Mol Cell Biol. 1992 Jan; 12(1):283-91. Atencio DP, Yaffe MP. PMID: 1729605.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    33. Uncoupling thermotolerance from the induction of heat shock proteins. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11091-4. Smith BJ, Yaffe MP. PMID: 1763024.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    34. A role for unsaturated fatty acids in mitochondrial movement and inheritance. J Cell Biol. 1991 Dec; 115(5):1249-57. Stewart LC, Yaffe MP. PMID: 1955472.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    35. Organelle inheritance in the yeast cell cycle. Trends Cell Biol. 1991 Dec; 1(6):160-4. Yaffe MP. PMID: 14731859.
      View in: PubMed   Mentions: 22     Fields:    
    36. A mutation in the yeast heat-shock factor gene causes temperature-sensitive defects in both mitochondrial protein import and the cell cycle. Mol Cell Biol. 1991 May; 11(5):2647-55. Smith BJ, Yaffe MP. PMID: 2017170.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    37. Analysis of mitochondrial function and assembly. Methods Enzymol. 1991; 194:627-43. Yaffe MP. PMID: 2005813.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    38. Embedded or not? Hydrophobic sequences and membranes. Trends Biochem Sci. 1990 Oct; 15(10):369-73. Singer SJ, Yaffe MP. PMID: 2251726.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    39. Temperature-sensitive yeast mutants defective in mitochondrial inheritance. J Cell Biol. 1990 Sep; 111(3):967-76. McConnell SJ, Stewart LC, Talin A, Yaffe MP. PMID: 2202739.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    40. A yeast protein, homologous to the proteolipid of the chromaffin granule proton-ATPase, is important for cell growth. Biochem Biophys Res Commun. 1990 Apr 30; 168(2):574-9. Apperson M, Jensen RE, Suda K, Witte C, Yaffe MP. PMID: 2139779.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    41. The major 45-kDa protein of the yeast mitochondrial outer membrane is not essential for cell growth or mitochondrial function. J Biol Chem. 1989 Dec 15; 264(35):21091-6. Yaffe MP, Jensen RE, Guido EC. PMID: 2687271.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    42. Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit. EMBO J. 1988 Dec 01; 7(12):3863-71. Jensen RE, Yaffe MP. PMID: 3061808.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    43. Import of proteins into yeast mitochondria: the purified matrix processing protease contains two subunits which are encoded by the nuclear MAS1 and MAS2 genes. EMBO J. 1988 Dec 01; 7(12):3857-62. Yang M, Jensen RE, Yaffe MP, Oppliger W, Schatz G. PMID: 2905264.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    44. MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease. EMBO J. 1988 May; 7(5):1439-47. Witte C, Jensen RE, Yaffe MP, Schatz G. PMID: 3044780.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    45. On the transfer of integral proteins into membranes. Proc Natl Acad Sci U S A. 1987 Apr; 84(7):1960-4. Singer SJ, Maher PA, Yaffe MP. PMID: 3470770.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    46. On the translocation of proteins across membranes. Proc Natl Acad Sci U S A. 1987 Feb; 84(4):1015-9. Singer SJ, Maher PA, Yaffe MP. PMID: 3469644.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    47. A yeast mutant temperature-sensitive for mitochondrial assembly is deficient in a mitochondrial protease activity that cleaves imported precursor polypeptides. EMBO J. 1985 Aug; 4(8):2069-74. Yaffe MP, Ohta S, Schatz G. PMID: 2866092.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    48. Two nuclear mutations that block mitochondrial protein import in yeast. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4819-23. Yaffe MP, Schatz G. PMID: 6235522.
      View in: PubMed   Mentions: 226     Fields:    Translation:AnimalsCells
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