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    Michael Yaffe

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentCell and Developmental Biology
    Address9500 Gilman Drive #0347
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Mechanisms of Mitochondrial Division and Inheritance
      NIH/NIGMS R01GM044614Apr 1, 1993 - Mar 31, 2006
      Role: Principal Investigator
      BIOGENESIS OF THE MITOCHONDRIAL OUTER MEMBRANE
      NIH/NIGMS R01GM035315Jul 1, 1985 - Jun 30, 1988
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Yaffe M, Noggle SA, Solomon SL. Raising the standards of stem cell line quality. Nat Cell Biol. 2016 Feb 25; 18(3):236-7. PMID: 26911906.
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      2. Dewitt ND, Yaffe M, Trounson A. Building stem-cell genomics in California and beyond. Nat Biotechnol. 2012 Jan; 30(1):20-5. PMID: 22231086.
        View in: PubMed
      3. Area-Gomez E, de Groof AJ, Boldogh I, Bird TD, Gibson GE, Koehler CM, Yu WH, Duff KE, Yaffe M, Pon LA, Schon EA. Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. Am J Pathol. 2009 Nov; 175(5):1810-6. PMID: 19834068.
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      4. Mazanka E, Alexander J, Yeh BJ, Charoenpong P, Lowery DM, Yaffe M, Weiss EL. The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry. PLoS Biol. 2008 Aug 19; 6(8):e203. PMID: 18715118.
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      5. Chiron S, Bobkova A, Zhou H, Yaffe M. CLASP regulates mitochondrial distribution in Schizosaccharomyces pombe. J Cell Biol. 2008 Jul 14; 182(1):41-9. PMID: 18606849.
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      6. Gourley PL, Hendricks JK, McDonald AE, Copeland RG, Yaffe M, Naviaux RK. Reactive biomolecular divergence in genetically altered yeast cells and isolated mitochondria as measured by biocavity laser spectroscopy: rapid diagnostic method for studying cellular responses to stress and disease. J Biomed Opt. 2007 Sep-Oct; 12(5):054003. PMID: 17994891.
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      7. Sesaki H, Dunn CD, Iijima M, Shepard KA, Yaffe M, Machamer CE, Jensen RE. Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p. J Cell Biol. 2006 Jun 5; 173(5):651-8. PMID: 16754953.
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      8. Meisinger C, Rissler M, Chacinska A, Szklarz LK, Milenkovic D, Kozjak V, Schönfisch B, Lohaus C, Meyer HE, Yaffe M, Guiard B, Wiedemann N, Pfanner N. The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev Cell. 2004 Jul; 7(1):61-71. PMID: 15239954.
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      9. Weir BA, Yaffe M. Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe. Mol Biol Cell. 2004 Apr; 15(4):1656-65. PMID: 14767070.
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      10. Yaffe M, Stuurman N, Vale RD. Mitochondrial positioning in fission yeast is driven by association with dynamic microtubules and mitotic spindle poles. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11424-8. PMID: 12972644.
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      11. Yaffe M. The cutting edge of mitochondrial fusion. Nat Cell Biol. 2003 Jun; 5(6):497-9. PMID: 12776123.
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      12. Sesaki H, Southard SM, Yaffe M, Jensen RE. Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell. 2003 Jun; 14(6):2342-56. PMID: 12808034.
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      13. Berger KH, Yaffe M. Mitochondrial DNA inheritance in Saccharomyces cerevisiae. Trends Microbiol. 2000 Nov; 8(11):508-13. PMID: 11121761.
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      14. Fekkes P, Shepard KA, Yaffe M. Gag3p, an outer membrane protein required for fission of mitochondrial tubules. J Cell Biol. 2000 Oct 16; 151(2):333-40. PMID: 11038180.
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      15. Kluck RM, Ellerby LM, Ellerby HM, Naiem S, Yaffe M, Margoliash E, Bredesen D, Mauk AG, Sherman F, Newmeyer DD. Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation. J Biol Chem. 2000 May 26; 275(21):16127-33. PMID: 10821864.
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      16. Yaffe M. Dynamic mitochondria. Nat Cell Biol. 1999 Oct; 1(6):E149-50. PMID: 10559975.
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      17. Fisk HA, Yaffe M. A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae. J Cell Biol. 1999 Jun 14; 145(6):1199-208. PMID: 10366593.
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      18. Yaffe M. The machinery of mitochondrial inheritance and behavior. Science. 1999 Mar 5; 283(5407):1493-7. PMID: 10066164.
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      19. Shepard KA, Yaffe M. The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance. J Cell Biol. 1999 Feb 22; 144(4):711-20. PMID: 10037792.
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      20. Berger KH, Yaffe M. Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol. 1998 Jul; 18(7):4043-52. PMID: 9632789.
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      21. Yaffe M. Mitochondrial morphogenesis: fusion factor for fly fertility. Curr Biol. 1997 Dec 1; 7(12):R782-3. PMID: 9382824.
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      22. Fisk HA, Yaffe M. Mutational analysis of Mdm1p function in nuclear and mitochondrial inheritance. J Cell Biol. 1997 Aug 11; 138(3):485-94. PMID: 9245780.
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      23. Berger KH, Sogo LF, Yaffe M. Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast. J Cell Biol. 1997 Feb 10; 136(3):545-53. PMID: 9024686.
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      24. Berger KH, Yaffe M. Mitochondrial distribution and inheritance. Experientia. 1996 Dec 15; 52(12):1111-6. PMID: 8988253.
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      25. Zha H, Fisk HA, Yaffe M, Mahajan N, Herman B, Reed JC. Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells. Mol Cell Biol. 1996 Nov; 16(11):6494-508. PMID: 8887678.
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      26. Yaffe M, Harata D, Verde F, Eddison M, Toda T, Nurse P. Microtubules mediate mitochondrial distribution in fission yeast. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11664-8. PMID: 8876193.
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      27. Nickas ME, Yaffe M. BRO1, a novel gene that interacts with components of the Pkc1p-mitogen-activated protein kinase pathway in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Jun; 16(6):2585-93. PMID: 8649366.
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      28. Yaffe M. Isolation and analysis of mitochondrial inheritance mutants from Saccharomyces cerevisiae. Methods Enzymol. 1995; 260:447-53. PMID: 8592466.
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      29. Sogo LF, Yaffe M. Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. J Cell Biol. 1994 Sep; 126(6):1361-73. PMID: 8089171.
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      30. McConnell SJ, Yaffe M. Intermediate filament formation by a yeast protein essential for organelle inheritance. Science. 1993 Apr 30; 260(5108):687-9. PMID: 8480179.
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      31. McConnell SJ, Yaffe M. Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein. J Cell Biol. 1992 Jul; 118(2):385-95. PMID: 1378448.
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      32. Atencio DP, Yaffe M. MAS5, a yeast homolog of DnaJ involved in mitochondrial protein import. Mol Cell Biol. 1992 Jan; 12(1):283-91. PMID: 1729605.
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      33. Smith BJ, Yaffe M. Uncoupling thermotolerance from the induction of heat shock proteins. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11091-4. PMID: 1763024.
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      34. Stewart LC, Yaffe M. A role for unsaturated fatty acids in mitochondrial movement and inheritance. J Cell Biol. 1991 Dec; 115(5):1249-57. PMID: 1955472.
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      35. Yaffe M. Organelle inheritance in the yeast cell cycle. Trends Cell Biol. 1991 Dec; 1(6):160-4. PMID: 14731859.
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      36. Smith BJ, Yaffe M. A mutation in the yeast heat-shock factor gene causes temperature-sensitive defects in both mitochondrial protein import and the cell cycle. Mol Cell Biol. 1991 May; 11(5):2647-55. PMID: 2017170.
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      37. Yaffe M. Analysis of mitochondrial function and assembly. Methods Enzymol. 1991; 194:627-43. PMID: 2005813.
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      38. Singer SJ, Yaffe M. Embedded or not? Hydrophobic sequences and membranes. Trends Biochem Sci. 1990 Oct; 15(10):369-73. PMID: 2251726.
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      39. McConnell SJ, Stewart LC, Talin A, Yaffe M. Temperature-sensitive yeast mutants defective in mitochondrial inheritance. J Cell Biol. 1990 Sep; 111(3):967-76. PMID: 2202739.
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      40. Apperson M, Jensen RE, Suda K, Witte C, Yaffe M. A yeast protein, homologous to the proteolipid of the chromaffin granule proton-ATPase, is important for cell growth. Biochem Biophys Res Commun. 1990 Apr 30; 168(2):574-9. PMID: 2139779.
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      41. Yaffe M, Jensen RE, Guido EC. The major 45-kDa protein of the yeast mitochondrial outer membrane is not essential for cell growth or mitochondrial function. J Biol Chem. 1989 Dec 15; 264(35):21091-6. PMID: 2687271.
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      42. Jensen RE, Yaffe M. Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit. EMBO J. 1988 Dec 1; 7(12):3863-71. PMID: 3061808.
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      43. Yang M, Jensen RE, Yaffe M, Oppliger W, Schatz G. Import of proteins into yeast mitochondria: the purified matrix processing protease contains two subunits which are encoded by the nuclear MAS1 and MAS2 genes. EMBO J. 1988 Dec 1; 7(12):3857-62. PMID: 2905264.
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      44. Witte C, Jensen RE, Yaffe M, Schatz G. MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease. EMBO J. 1988 May; 7(5):1439-47. PMID: 3044780.
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      45. Singer SJ, Maher PA, Yaffe M. On the transfer of integral proteins into membranes. Proc Natl Acad Sci U S A. 1987 Apr; 84(7):1960-4. PMID: 3470770.
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      46. Singer SJ, Maher PA, Yaffe M. On the translocation of proteins across membranes. Proc Natl Acad Sci U S A. 1987 Feb; 84(4):1015-9. PMID: 3469644.
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      47. Yaffe M, Ohta S, Schatz G. A yeast mutant temperature-sensitive for mitochondrial assembly is deficient in a mitochondrial protease activity that cleaves imported precursor polypeptides. EMBO J. 1985 Aug; 4(8):2069-74. PMID: 2866092.
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      48. Yaffe M, Schatz G. Two nuclear mutations that block mitochondrial protein import in yeast. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4819-23. PMID: 6235522.
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