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Timothy Rodwell

TitleAssociate Professor In Residence
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0643
La Jolla CA 92093
Phone858-822-4353
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    Collapse Research 
    Collapse Research Activities and Funding
    Culture-free next generation sequencing for rapid detection of drug-resistant tuberculosis
    NIH/NIAID R21AI135756Jan 15, 2018 - Dec 31, 2019
    Role: Principal Investigator
    An Integrated Tabletop Platform for Rapid Detection of XDR-TB in Clinical Samples
    NIH/NIAID R01AI111435Jul 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Binational Transmission of Multidrug-Resistant Tuberculosis, California &Mexico
    NIH/NIAID K01AI083784Sep 15, 2009 - Aug 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hazbón MH, Rigouts L, Schito M, Ezewudo M, Kudo T, Itoh T, Ohkuma M, Kiss K, Wu L, Ma J, Hamada M, Strong M, Salfinger M, Daley CL, Nick JA, Lee JS, Rastogi N, Couvin D, Hurtado-Ortiz R, Bizet C, Suresh A, Rodwell T, Albertini A, Lacourciere KA, Deheer-Graham A, Alexander S, Russell JE, Bradford R, Riojas MA. Mycobacterial biomaterials and resources for researchers. Pathog Dis. 2018 Jun 01; 76(4). PMID: 29846561.
      View in: PubMed
    2. Groessl EJ, Ganiats TG, Hillery N, Trollip A, Jackson RL, Catanzaro DG, Rodwell T, Garfein RS, Rodrigues C, Crudu V, Victor TC, Catanzaro A. Cost analysis of rapid diagnostics for drug-resistant tuberculosis. BMC Infect Dis. 2018 03 02; 18(1):102. PMID: 29499645.
      View in: PubMed
    3. Miotto P, Tessema B, Tagliani E, Chindelevitch L, Starks AM, Emerson C, Hanna D, Kim PS, Liwski R, Zignol M, Gilpin C, Niemann S, Denkinger CM, Fleming J, Warren RM, Crook D, Posey J, Gagneux S, Hoffner S, Rodrigues C, Comas I, Engelthaler DM, Murray M, Alland D, Rigouts L, Lange C, Dheda K, Hasan R, Ranganathan UDK, McNerney R, Ezewudo M, Cirillo DM, Schito M, Köser CU, Rodwell T. A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis. Eur Respir J. 2017 Dec; 50(6). PMID: 29284687.
      View in: PubMed
    4. Rice JP, Seifert M, Moser KS, Rodwell T. Performance of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis and rifampin resistance in a low-incidence, high-resource setting. PLoS One. 2017; 12(10):e0186139. PMID: 29016684.
      View in: PubMed
    5. Seifert M, Georghiou SB, Garfein RS, Catanzaro D, Rodwell T. Impact of Fluoroquinolone Use on Mortality Among a Cohort of Patients With Suspected Drug-Resistant Tuberculosis. Clin Infect Dis. 2017 Sep 01; 65(5):772-778. PMID: 28475735.
      View in: PubMed
    6. Georghiou SB, Seifert M, Catanzaro DG, Garfein RS, Rodwell T. Increased Tuberculosis Patient Mortality Associated with Mycobacterium tuberculosis Mutations Conferring Resistance to Second-Line Antituberculous Drugs. J Clin Microbiol. 2017 Jun; 55(6):1928-1937. PMID: 28404672.
      View in: PubMed
    7. Catanzaro DG, Trollip AP, Seifert M, Georghiou SB, Garfein RS, Rodwell T, Catanzaro A, Eisenach KD. Evaluation of the microscopic observation drug susceptibility assay for the detection of first- and second-line drug susceptibility for Mycobacterium tuberculosis. Eur Respir J. 2017 Apr; 49(4). PMID: 28381434.
      View in: PubMed
    8. Dolinger DL, Colman RE, Engelthaler DM, Rodwell T. Next-generation sequencing-based user-friendly platforms for drug-resistant tuberculosis diagnosis: A promise for the near future. Int J Mycobacteriol. 2016 Dec; 5 Suppl 1:S27-S28. PMID: 28043592.
      View in: PubMed
    9. Bojorquez I, Salazar I, Garfein RS, Cerecer P, Rodwell T. Surveillance or support: The experience of direct observation during tuberculosis treatment. Glob Public Health. 2016 Oct 16; 1-15. PMID: 27748157.
      View in: PubMed
    10. Georghiou SB, Seifert M, Lin SY, Catanzaro D, Garfein RS, Jackson RL, Crudu V, Rodrigues C, Victor TC, Catanzaro A, Rodwell T. Shedding light on the performance of a pyrosequencing assay for drug-resistant tuberculosis diagnosis. BMC Infect Dis. 2016 08 31; 16:458. PMID: 27576542; PMCID: PMC5006534.
    11. Kapasi AJ, Dittrich S, González IJ, Rodwell T. Host Biomarkers for Distinguishing Bacterial from Non-Bacterial Causes of Acute Febrile Illness: A Comprehensive Review. PLoS One. 2016; 11(8):e0160278. PMID: 27486746; PMCID: PMC4972355.
    12. Kambli P, Ajbani K, Nikam C, Sadani M, Shetty A, Udwadia Z, Georghiou SB, Rodwell T, Catanzaro A, Rodrigues C. Corrigendum to "Correlating rrs and eis promoter mutations in clinical isolates of Mycobacterium tuberculosis with phenotypic susceptibility levels to the second-line injectables" [Int. J. Mycobacteriol. 5(1) 2016 1-6]. Int J Mycobacteriol. 2016 09; 5(3):370-372. PMID: 27847030.
      View in: PubMed
    13. Colman RE, Anderson J, Lemmer D, Lehmkuhl E, Georghiou SB, Heaton H, Wiggins K, Gillece JD, Schupp JM, Catanzaro DG, Crudu V, Cohen T, Rodwell T, Engelthaler DM. Rapid Drug Susceptibility Testing of Drug-Resistant Mycobacterium tuberculosis Isolates Directly from Clinical Samples by Use of Amplicon Sequencing: a Proof-of-Concept Study. J Clin Microbiol. 2016 08; 54(8):2058-67. PMID: 27225403; PMCID: PMC4963505.
    14. Berrada ZL, Lin SY, Rodwell T, Nguyen D, Schecter GF, Pham L, Janda JM, Elmaraachli W, Catanzaro A, Desmond E. Rifabutin and rifampin resistance levels and associated rpoB mutations in clinical isolates of Mycobacterium tuberculosis complex. Diagn Microbiol Infect Dis. 2016 Jun; 85(2):177-81. PMID: 27036978; PMCID: PMC4873381 [Available on 06/01/17].
    15. Seifert M, Georghiou SB, Catanzaro D, Rodrigues C, Crudu V, Victor TC, Garfein RS, Catanzaro A, Rodwell T. MTBDRplus and MTBDRsl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis. J Clin Microbiol. 2016 Apr; 54(4):912-8. PMID: 26763971; PMCID: PMC4809938 [Available on 10/01/16].
    16. Kambli P, Ajbani K, Nikam C, Sadani M, Shetty A, Udwadia Z, Georghiou SB, Rodwell T, Catanzaro A, Rodrigues C. Correlating rrs and eis promoter mutations in clinical isolates of Mycobacterium tuberculosis with phenotypic susceptibility levels to the second-line injectables. Int J Mycobacteriol. 2016 Mar; 5(1):1-6. PMID: 26927983.
      View in: PubMed
    17. Catanzaro A, Rodwell T, Catanzaro DG, Garfein RS, Jackson RL, Seifert M, Georghiou SB, Trollip A, Groessl E, Hillery N, Crudu V, Victor TC, Rodrigues C, Lin GS, Valafar F, Desmond E, Eisenach K. Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis. PLoS One. 2015; 10(8):e0136861. PMID: 26322781; PMCID: PMC4556461.
    18. Torres JN, Paul LV, Rodwell T, Victor TC, Amallraja AM, Elghraoui A, Goodmanson AP, Ramirez-Busby SM, Chawla A, Zadorozhny V, Streicher EM, Sirgel FA, Catanzaro D, Rodrigues C, Gler MT, Crudu V, Catanzaro A, Valafar F. Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates. Emerg Microbes Infect. 2015 Jul; 4(7):e42. PMID: 26251830; PMCID: PMC4522615.
    19. Colman RE, Schupp JM, Hicks ND, Smith DE, Buchhagen JL, Valafar F, Crudu V, Romancenco E, Noroc E, Jackson L, Catanzaro DG, Rodwell T, Catanzaro A, Keim P, Engelthaler DM. Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing. PLoS One. 2015; 10(5):e0126626. PMID: 25970423; PMCID: PMC4430321.
    20. Avalos E, Catanzaro D, Catanzaro A, Ganiats T, Brodine S, Alcaraz J, Rodwell T. Frequency and geographic distribution of gyrA and gyrB mutations associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis isolates: a systematic review. PLoS One. 2015; 10(3):e0120470. PMID: 25816236; PMCID: PMC4376704.
    21. Seifert M, Catanzaro D, Catanzaro A, Rodwell T. Genetic mutations associated with isoniazid resistance in Mycobacterium tuberculosis: a systematic review. PLoS One. 2015; 10(3):e0119628. PMID: 25799046; PMCID: PMC4370653.
    22. Kambli P, Ajbani K, Sadani M, Nikam C, Shetty A, Udwadia Z, Georghiou SB, Rodwell T, Catanzaro A, Rodrigues C. Defining multidrug-resistant tuberculosis: correlating GenoType MTBDRplus assay results with minimum inhibitory concentrations. Diagn Microbiol Infect Dis. 2015 May; 82(1):49-53. PMID: 25749461; PMCID: PMC4414878.
    23. Kambli P, Ajbani K, Sadani M, Nikam C, Shetty A, Udwadia Z, Rodwell T, Catanzaro A, Rodrigues C. Correlating Minimum Inhibitory Concentrations of ofloxacin and moxifloxacin with gyrA mutations using the genotype MTBDRsl assay. Tuberculosis (Edinb). 2015 Mar; 95(2):137-41. PMID: 25522842; PMCID: PMC4361297.
    24. Hillery N, Groessl EJ, Trollip A, Catanzaro D, Jackson L, Rodwell T, Garfein RS, Lin SY, Eisenach K, Ganiats TG, Park D, Valafar F, Rodrigues C, Crudu V, Victor TC, Catanzaro A. The Global Consortium for Drug-resistant Tuberculosis Diagnostics (GCDD): design of a multi-site, head-to-head study of three rapid tests to detect extensively drug-resistant tuberculosis. Trials. 2014 Nov 06; 15:434. PMID: 25377177; PMCID: PMC4232628.
    25. Ajbani K, Lin SY, Rodrigues C, Nguyen D, Arroyo F, Kaping J, Jackson L, Garfein RS, Catanzaro D, Eisenach K, Victor TC, Crudu V, Gler MT, Ismail N, Desmond E, Catanzaro A, Rodwell T. Evaluation of pyrosequencing for detecting extensively drug-resistant Mycobacterium tuberculosis among clinical isolates from four high-burden countries. Antimicrob Agents Chemother. 2015 Jan; 59(1):414-20. PMID: 25367911; PMCID: PMC4291380.
    26. Bennett RJ, Brodine S, Waalen J, Moser K, Rodwell T. Prevalence and treatment of latent tuberculosis infection among newly arrived refugees in San Diego County, January 2010-October 2012. Am J Public Health. 2014 Apr; 104(4):e95-e102. PMID: 24524534; PMCID: PMC4025726.
    27. Rodwell T, Valafar F, Douglas J, Qian L, Garfein RS, Chawla A, Torres J, Zadorozhny V, Kim MS, Hoshide M, Catanzaro D, Jackson L, Lin G, Desmond E, Rodrigues C, Eisenach K, Victor TC, Ismail N, Crudu V, Gler MT, Catanzaro A. Predicting extensively drug-resistant Mycobacterium tuberculosis phenotypes with genetic mutations. J Clin Microbiol. 2014 Mar; 52(3):781-9. PMID: 24353002; PMCID: PMC3957771.
    28. Lin SY, Rodwell T, Victor TC, Rider EC, Pham L, Catanzaro A, Desmond EP. Pyrosequencing for rapid detection of extensively drug-resistant Mycobacterium tuberculosis in clinical isolates and clinical specimens. J Clin Microbiol. 2014 Feb; 52(2):475-82. PMID: 24478476; PMCID: PMC3911348.
    29. Bojorquez I, Barnes RF, Flood J, López-Gatell H, Garfein RS, Bäcker CE, Alpuche C, Vinetz JM, Catanzaro A, Kato-Maeda M, Rodwell T. Multidrug-resistant tuberculosis among patients in Baja California, Mexico, and Hispanic patients in California. Am J Public Health. 2013 Jul; 103(7):1301-5. PMID: 23678924; PMCID: PMC3682598.
    30. Shin SS, Gallardo M, Lozada R, Abramovitz D, Burgos JL, Laniado-Laborin R, Rodwell T, Novotny TE, Strathdee SA, Garfein RS. Cigarette-Smoking Intensity and Interferon-Gamma Release Assay Conversion among Persons Who Inject Drugs: A Cohort Study. Pulm Med. 2012; 2012:828106. PMID: 23304497; PMCID: PMC3529865.
    31. Rodwell T, Kapasi AJ, Barnes RF, Moser KS. Factors associated with genotype clustering of Mycobacterium tuberculosis isolates in an ethnically diverse region of southern California, United States. Infect Genet Evol. 2012 Dec; 12(8):1917-25. PMID: 22982156; PMCID: PMC3723456.
    32. Yen YF, Rodwell T, Yen MY, Hsu YH, Chuang P, Li LH, Su LW, Yang YH, Jiang XR, Fang YC, Garfein RS. HIV infection risk among injection drug users in a methadone maintenance treatment program, Taipei, Taiwan 2007-2010. Am J Drug Alcohol Abuse. 2012 Nov; 38(6):544-50. PMID: 22783806; PMCID: PMC4229362.
    33. Velasquez MG, Laniado-Laborin R, Rodwell T, Cerecer P, Lozada R, Cuevas-Mota J, Burgos JL, Garfein RS. Tuberculosis testing among populations with high HIV risk in Tijuana, Baja California, Mexico. Rev Panam Salud Publica. 2012 Jul; 32(1):30-5. PMID: 22910722; PMCID: PMC3711229.
    34. Georghiou SB, Magana M, Garfein RS, Catanzaro DG, Catanzaro A, Rodwell T. Evaluation of genetic mutations associated with Mycobacterium tuberculosis resistance to amikacin, kanamycin and capreomycin: a systematic review. PLoS One. 2012; 7(3):e33275. PMID: 22479378; PMCID: PMC3315572.
    35. Barnes RF, Moore ML, Garfein RS, Brodine S, Strathdee SA, Rodwell T. Trends in mortality of tuberculosis patients in the United States: the long-term perspective. Ann Epidemiol. 2011 Oct; 21(10):791-5. PMID: 21820320; PMCID: PMC3166369.
    36. Rondinelli AJ, Morris MD, Rodwell T, Moser KS, Paida P, Popper ST, Brouwer KC. Under- and over-nutrition among refugees in San Diego County, California. J Immigr Minor Health. 2011 Feb; 13(1):161-8. PMID: 20505992; PMCID: PMC3021711.
    37. Rodwell T, Robertson AM, Aguirre N, Vera A, Anderson CM, Lozada R, Chait L, Schooley RT, Zhang XQ, Strathdee SA. Pandemic (H1N1) 2009 Surveillance in Marginalized Populations, Tijuana, Mexico. Emerg Infect Dis. 2010 Aug; 16(8):1292-5. PMID: 20678328; PMCID: PMC3298300.
    38. Garfein RS, Laniado-Laborin R, Rodwell T, Lozada R, Deiss R, Burgos JL, Cuevas-Mota J, Cerecer P, Moser K, Volker ML, Strathdee SA. Latent tuberculosis among persons at risk for infection with HIV, Tijuana, Mexico. Emerg Infect Dis. 2010 May; 16(5):757-63. PMID: 20409363.
      View in: PubMed
    39. Rodwell T, Kapasi AJ, Moore M, Milian-Suazo F, Harris B, Guerrero LP, Moser K, Strathdee SA, Garfein RS. Tracing the origins of Mycobacterium bovis tuberculosis in humans in the USA to cattle in Mexico using spoligotyping. Int J Infect Dis. 2010 Sep; 14 Suppl 3:e129-35. PMID: 20399697; PMCID: PMC2920372.
    40. Rodwell T, Barnes RF, Moore M, Strathdee SA, Raich A, Moser KS, Garfein RS. HIV-tuberculosis coinfection in Southern California: evaluating disparities in disease burden. Am J Public Health. 2010 Apr 01; 100 Suppl 1:S178-85. PMID: 20147681; PMCID: PMC2837460.
    41. Morris MD, Popper ST, Rodwell T, Brodine SK, Brouwer KC. Healthcare barriers of refugees post-resettlement. J Community Health. 2009 Dec; 34(6):529-38. PMID: 19705264.
      View in: PubMed
    42. Deiss R, Garfein RS, Lozada R, Burgos JL, Brouwer KC, Moser KS, Zuniga ML, Rodwell T, Ojeda VD, Strathdee SA. Influences of cross-border mobility on tuberculosis diagnoses and treatment interruption among injection drug users in Tijuana, Mexico. Am J Public Health. 2009 Aug; 99(8):1491-5. PMID: 19542040.
      View in: PubMed
    43. Deiss RG, Rodwell T, Garfein RS. Tuberculosis and illicit drug use: review and update. Clin Infect Dis. 2009 Jan 01; 48(1):72-82. PMID: 19046064; PMCID: PMC3110742.
    44. Rodwell T, Moore M, Moser KS, Brodine SK, Strathdee SA. Tuberculosis from Mycobacterium bovis in binational communities, United States. Emerg Infect Dis. 2008 Jun; 14(6):909-16. PMID: 18507901; PMCID: PMC2600278.
    45. O'Connell-Rodwell CE, Wood JD, Kinzley C, Rodwell T, Poole JH, Puria S. Wild African elephants (Loxodonta africana) discriminate between familiar and unfamiliar conspecific seismic alarm calls. J Acoust Soc Am. 2007 Aug; 122(2):823-30. PMID: 17672633.
      View in: PubMed