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    Scott Matthews

    TitleClinical Professor
    SchoolUniversity of California, San Diego
    DepartmentPsychiatry
    Address9500 Gilman Drive #9116-A
    CA La Jolla 92093
    Phone619-642-1242
    vCardDownload vCard

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      Biography

      After receiving his MD from UMDNJ-New Jersey Medical School in 1998, Dr. Matthews completed his internship and residency in psychiatry at UC San Diego, and was Chief Resident at UC San Diego Outpatient Psychiatric Services in his final year of residency. He then completed formal research training in functional brain imaging in mood disorders in UCSD’s Fellowship in Biological Psychiatry and Neuroscience. He is currently Assistant Adjunct Professor of Psychiatry at UC San Diego. Dr. Matthews is actively involved in the American Psychosomatic Society, and has served on several committees of this organization.

      Research Interests

      Dr. Matthews uses fMRI to study the neural substrates involved in mood disorders. He has published several articles that describe the involvement of the anterior cingulate cortex in cognitive processing and autonomic nervous system regulation. Dr. Matthews has received early academic career funding to implement these paradigms in patients with current major depressive disorder. His current work involves using cognitive and emotional tasks during fMRI to probe the neural circuitry involved in major depression and related mood disorders.

      Clinical Focus

      Dr. Matthews is a Staff Psychiatrist at VA San Diego Healthcare System where he is Chief of the Consultation Liaison Division of the VA Psychiatry Service. He also provides care for veterans in one of the VA’s outpatient mood clinics. Dr. Matthews is actively involved in teaching residents and medical students.


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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Atkinson JH, Slater MA, Capparelli EV, Patel SM, Wolfson T, Gamst A, Abramson IS, Wallace MS, Funk SD, Rutledge TR, Wetherell JL, Matthews S, Zisook S, Garfin SR. A randomized controlled trial of gabapentin for chronic low back pain with and without a radiating component. Pain. 2016 07; 157(7):1499-507. PMID: 26963844; PMCID: PMC5001843 [Available on 07/01/17].
        View in: PubMed, PubMed Central
      2. Buchsbaum MS, Simmons AN, DeCastro A, Farid N, Matthews S. Clusters of Low (18)F-Fluorodeoxyglucose Uptake Voxels in Combat Veterans with Traumatic Brain Injury and Post-Traumatic Stress Disorder. J Neurotrauma. 2015 Nov 15; 32(22):1736-50. PMID: 25915799.
        View in: PubMed
      3. Schiehser DM, Delano-Wood L, Jak AJ, Matthews S, Simmons AN, Jacobson MW, Filoteo JV, Bondi MW, Orff HJ, Liu L. Validation of the Modified Fatigue Impact Scale in mild to moderate traumatic brain injury. J Head Trauma Rehabil. 2015 Mar-Apr; 30(2):116-21. PMID: 24413076.
        View in: PubMed
      4. Shu IW, Onton JA, O'Connell RM, Simmons AN, Matthews S. Combat veterans with comorbid PTSD and mild TBI exhibit a greater inhibitory processing ERP from the dorsal anterior cingulate cortex. Psychiatry Res. 2014 Oct 30; 224(1):58-66. PMID: 25150386.
        View in: PubMed
      5. Shu IW, Onton JA, Prabhakar N, O'Connell RM, Simmons AN, Matthews S. Combat veterans with PTSD after mild TBI exhibit greater ERPs from posterior-medial cortical areas while appraising facial features. J Affect Disord. 2014 Feb; 155:234-40. PMID: 24342149.
        View in: PubMed
      6. Klabunde M, Acheson DT, Boutelle KN, Matthews S, Kaye WH. Interoceptive sensitivity deficits in women recovered from bulimia nervosa. Eat Behav. 2013 Dec; 14(4):488-92. PMID: 24183142; PMCID: PMC3817494.
        View in: PubMed, PubMed Central
      7. Matthews S, Spadoni AD, Lohr JB, Strigo IA, Simmons AN. Diffusion tensor imaging evidence of white matter disruption associated with loss versus alteration of consciousness in warfighters exposed to combat in Operations Enduring and Iraqi Freedom. Psychiatry Res. 2012 Nov 30; 204(2-3):149-54. PMID: 23149025; PMCID: PMC3866101.
        View in: PubMed, PubMed Central
      8. Simmons AN, Flagan TM, Wittmann M, Strigo IA, Matthews S, Donovan H, Lohr JB, Paulus MP. The effects of temporal unpredictability in anticipation of negative events in combat veterans with PTSD. J Affect Disord. 2013 Apr 25; 146(3):426-32. PMID: 22910447.
        View in: PubMed
      9. Strigo IA, Matthews S, Simmons AN, Oberndorfer T, Klabunde M, Reinhardt LE, Kaye WH. Altered insula activation during pain anticipation in individuals recovered from anorexia nervosa: evidence of interoceptive dysregulation. Int J Eat Disord. 2013 Jan; 46(1):23-33. PMID: 22836447; PMCID: PMC3507323.
        View in: PubMed, PubMed Central
      10. Paulus MP, Schuckit MA, Tapert SF, Tolentino NJ, Matthews S, Smith TL, Trim RS, Hall SA, Simmons AN. High versus low level of response to alcohol: evidence of differential reactivity to emotional stimuli. Biol Psychiatry. 2012 Nov 15; 72(10):848-55. PMID: 22608014; PMCID: PMC3433640.
        View in: PubMed, PubMed Central
      11. Matthews S, Spadoni A, Knox K, Strigo I, Simmons A. Combat-exposed war veterans at risk for suicide show hyperactivation of prefrontal cortex and anterior cingulate during error processing. Psychosom Med. 2012 Jun; 74(5):471-5. PMID: 22511726; PMCID: PMC4018224.
        View in: PubMed, PubMed Central
      12. Simmons AN, Fitzpatrick S, Strigo IA, Potterat EG, Johnson DC, Matthews S, Orden KF, Swain JL, Paulus MP. Altered insula activation in anticipation of changing emotional states: neural mechanisms underlying cognitive flexibility in Special Operations Forces personnel. Neuroreport. 2012 Mar 07; 23(4):234-9. PMID: 22222502.
        View in: PubMed
      13. Simmons AN, Thayer RE, Spadoni AD, Matthews S, Strigo IA, Tapert SF. The parametric, psychological, neuropsychological, and neuroanatomical properties of self and world evaluation. PLoS One. 2012; 7(2):e31509. PMID: 22348093; PMCID: PMC3278451.
        View in: PubMed, PubMed Central
      14. Schuckit MA, Tapert S, Matthews S, Paulus MP, Tolentino NJ, Smith TL, Trim RS, Hall S, Simmons A. fMRI differences between subjects with low and high responses to alcohol during a stop signal task. Alcohol Clin Exp Res. 2012 Jan; 36(1):130-40. PMID: 22003983; PMCID: PMC3253183.
        View in: PubMed, PubMed Central
      15. Simmons AN, Matthews S, Strigo IA, Baker DG, Donovan HK, Motezadi A, Stein MB, Paulus MP. Altered amygdala activation during face processing in Iraqi and Afghanistani war veterans. Biol Mood Anxiety Disord. 2011 Oct 12; 1(1):6. PMID: 22738183; PMCID: PMC3384263.
        View in: PubMed, PubMed Central
      16. Padula CB, Simmons AN, Matthews S, Robinson SK, Tapert SF, Schuckit MA, Paulus MP. Alcohol attenuates activation in the bilateral anterior insula during an emotional processing task: a pilot study. Alcohol Alcohol. 2011 Sep-Oct; 46(5):547-52. PMID: 21665869; PMCID: PMC3201697.
        View in: PubMed, PubMed Central
      17. Simmons AN, Matthews S. Neural circuitry of PTSD with or without mild traumatic brain injury: a meta-analysis. Neuropharmacology. 2012 Feb; 62(2):598-606. PMID: 21420986.
        View in: PubMed
      18. Oberndorfer TA, Kaye WH, Simmons AN, Strigo IA, Matthews S. Demand-specific alteration of medial prefrontal cortex response during an inhibition task in recovered anorexic women. Int J Eat Disord. 2011 Jan; 44(1):1-8. PMID: 20127942.
        View in: PubMed
      19. Matthews S, Simmons A, Strigo I. The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion. Psychiatry Res. 2011 Jan 30; 191(1):76-9. PMID: 21144713.
        View in: PubMed
      20. Strigo IA, Simmons AN, Matthews S, Craig AD. The relationship between amygdala activation and passive exposure time to an aversive cue during a continuous performance task. PLoS One. 2010 Nov 29; 5(11):e15093. PMID: 21124739; PMCID: PMC2993966.
        View in: PubMed, PubMed Central
      21. Strigo IA, Simmons AN, Matthews S, Grimes EM, Allard CB, Reinhardt LE, Paulus MP, Stein MB. Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence. Biol Psychiatry. 2010 Sep 01; 68(5):442-50. PMID: 20553750.
        View in: PubMed
      22. Trim RS, Simmons AN, Tolentino NJ, Hall SA, Matthews S, Robinson SK, Smith TL, Padula CB, Paulus MP, Tapert SF, Schuckit MA. Acute ethanol effects on brain activation in low- and high-level responders to alcohol. Alcohol Clin Exp Res. 2010 Jul; 34(7):1162-70. PMID: 20477775; PMCID: PMC3774836.
        View in: PubMed, PubMed Central
      23. Matthews S, Strigo IA, Simmons AN, O'Connell RM, Reinhardt LE, Moseley SA. A multimodal imaging study in U.S. veterans of Operations Iraqi and Enduring Freedom with and without major depression after blast-related concussion. Neuroimage. 2011 Jan; 54 Suppl 1:S69-75. PMID: 20451622.
        View in: PubMed
      24. Matthews S, Simmons AN, Strigo IA, Arce E, Stein MB, Paulus MP. Escitalopram attenuates posterior cingulate activity during self-evaluation in healthy volunteers. Psychiatry Res. 2010 May 30; 182(2):81-7. PMID: 20418072; PMCID: PMC2882791.
        View in: PubMed, PubMed Central
      25. Camacho A, Simmons AN, Ng B, Matthews S, Akiskal HS. A factor analysis of different temperament domains in a border region in rural Southern California. J Affect Disord. 2010 Oct; 126(1-2):46-8. PMID: 20392499; PMCID: PMC3782388.
        View in: PubMed, PubMed Central
      26. Strigo IA, Matthews S, Simmons AN. Right anterior insula hypoactivity during anticipation of homeostatic shifts in major depressive disorder. Psychosom Med. 2010 Apr; 72(3):316-23. PMID: 20100882; PMCID: PMC2884370.
        View in: PubMed, PubMed Central
      27. Yang TT, Simmons AN, Matthews S, Tapert SF, Frank GK, Max JE, Bischoff-Grethe A, Lansing AE, Brown G, Strigo IA, Wu J, Paulus MP. Adolescents with major depression demonstrate increased amygdala activation. J Am Acad Child Adolesc Psychiatry. 2010 Jan; 49(1):42-51. PMID: 20215925; PMCID: PMC2935523.
        View in: PubMed, PubMed Central
      28. Simmons A, Strigo IA, Matthews S, Paulus MP, Stein MB. Initial evidence of a failure to activate right anterior insula during affective set shifting in posttraumatic stress disorder. Psychosom Med. 2009 May; 71(4):373-7. PMID: 19398499; PMCID: PMC2888032.
        View in: PubMed, PubMed Central
      29. Yang TT, Simmons AN, Matthews S, Tapert SF, Frank GK, Bischoff-Grethe A, Lansing AE, Wu J, Brown GG, Paulus MP. Depressed adolescents demonstrate greater subgenual anterior cingulate activity. Neuroreport. 2009 Mar 04; 20(4):440-4. PMID: 19218875; PMCID: PMC2672880.
        View in: PubMed, PubMed Central
      30. Matthews S, Simmons A, Strigo I, Gianaros P, Yang T, Paulus M. Inhibition-related activity in subgenual cingulate is associated with symptom severity in major depression. Psychiatry Res. 2009 Apr 30; 172(1):1-6. PMID: 19239982.
        View in: PubMed
      31. Yang TT, Simmons AN, Matthews S, Tapert SF, Frank GK, Bischoff-Grethe A, Lansing AE, Wu J, Paulus MP. Adolescent subgenual anterior cingulate activity is related to harm avoidance. Neuroreport. 2009 Jan 07; 20(1):19-23. PMID: 19034055; PMCID: PMC2852645.
        View in: PubMed, PubMed Central
      32. Strigo IA, Simmons AN, Matthews S, Craig AD, Paulus MP. Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain. Arch Gen Psychiatry. 2008 Nov; 65(11):1275-84. PMID: 18981339; PMCID: PMC2702160.
        View in: PubMed, PubMed Central
      33. Simmons AN, Paulus MP, Thorp SR, Matthews S, Norman SB, Stein MB. Functional activation and neural networks in women with posttraumatic stress disorder related to intimate partner violence. Biol Psychiatry. 2008 Oct 15; 64(8):681-90. PMID: 18639236; PMCID: PMC2634744.
        View in: PubMed, PubMed Central
      34. Matthews S, Strigo IA, Simmons AN, Yang TT, Paulus MP. Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder. J Affect Disord. 2008 Nov; 111(1):13-20. PMID: 18603301.
        View in: PubMed
      35. Simmons A, Matthews S, Feinstein JS, Hitchcock C, Paulus MP, Stein MB. Anxiety vulnerability is associated with altered anterior cingulate response to an affective appraisal task. Neuroreport. 2008 Jul 02; 19(10):1033-7. PMID: 18580574.
        View in: PubMed
      36. Strigo IA, Simmons AN, Matthews S, Craig AD, Paulus MP. Increased affective bias revealed using experimental graded heat stimuli in young depressed adults: evidence of "emotional allodynia". Psychosom Med. 2008 Apr; 70(3):338-44. PMID: 18378870; PMCID: PMC2742693.
        View in: PubMed, PubMed Central
      37. Yang TT, Simmons AN, Matthews S, Tapert SF, Bischoff-Grethe A, Frank GK, Arce E, Paulus MP. Increased amygdala activation is related to heart rate during emotion processing in adolescent subjects. Neurosci Lett. 2007 Nov 27; 428(2-3):109-14. PMID: 18029095; PMCID: PMC2171034.
        View in: PubMed, PubMed Central
      38. Simmons A, Matthews S, Paulus MP, Stein MB. Intolerance of uncertainty correlates with insula activation during affective ambiguity. Neurosci Lett. 2008 Jan 10; 430(2):92-7. PMID: 18079060; PMCID: PMC2692473.
        View in: PubMed, PubMed Central
      39. Matthews S, Simmons AN, Strigo I, Jang K, Stein MB, Paulus MP. Heritability of anterior cingulate response to conflict: an fMRI study in female twins. Neuroimage. 2007 Oct 15; 38(1):223-7. PMID: 17707125.
        View in: PubMed
      40. Atkinson JH, Slater MA, Capparelli EV, Wallace MS, Zisook S, Abramson I, Matthews S, Garfin SR. Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial. J Clin Psychopharmacol. 2007 Apr; 27(2):135-42. PMID: 17414235.
        View in: PubMed
      41. Ng B, Camacho A, Simmons A, Matthews S. Ethnicity and use of alternative products in psychiatric patients. Psychosomatics. 2006 Sep-Oct; 47(5):408-13. PMID: 16959929.
        View in: PubMed
      42. Simmons A, Strigo I, Matthews S, Paulus MP, Stein MB. Anticipation of aversive visual stimuli is associated with increased insula activation in anxiety-prone subjects. Biol Psychiatry. 2006 Aug 15; 60(4):402-9. PMID: 16919527.
        View in: PubMed
      43. Simmons A, Stein MB, Matthews S, Feinstein JS, Paulus MP. Affective ambiguity for a group recruits ventromedial prefrontal cortex. Neuroimage. 2006 Jan 15; 29(2):655-61. PMID: 16125977.
        View in: PubMed
      44. Matthews S, Nelesen RA, Dimsdale JE. Depressive symptoms are associated with increased systemic vascular resistance to stress. Psychosom Med. 2005 Jul-Aug; 67(4):509-13. PMID: 16046361.
        View in: PubMed
      45. Matthews S, Simmons AN, Arce E, Paulus MP. Dissociation of inhibition from error processing using a parametric inhibitory task during functional magnetic resonance imaging. Neuroreport. 2005 May 12; 16(7):755-60. PMID: 15858420.
        View in: PubMed
      46. Camacho A, Matthews S, Murray B, Dimsdale JE. Use of GHB compounds among college students. Am J Drug Alcohol Abuse. 2005; 31(4):601-7. PMID: 16318039.
        View in: PubMed
      47. Hong S, Johnson TA, Farag NH, Guy HJ, Matthews S, Ziegler MG, Mills PJ. Attenuation of T-lymphocyte demargination and adhesion molecule expression in response to moderate exercise in physically fit individuals. J Appl Physiol (1985). 2005 Mar; 98(3):1057-63. PMID: 15501922.
        View in: PubMed
      48. Simmons A, Matthews S, Stein MB, Paulus MP. Anticipation of emotionally aversive visual stimuli activates right insula. Neuroreport. 2004 Oct 05; 15(14):2261-5. PMID: 15371746.
        View in: PubMed
      49. Matthews S, Simmons AN, Lane SD, Paulus MP. Selective activation of the nucleus accumbens during risk-taking decision making. Neuroreport. 2004 Sep 15; 15(13):2123-7. PMID: 15486494.
        View in: PubMed
      50. Matthews S, Paulus MP, Simmons AN, Nelesen RA, Dimsdale JE. Functional subdivisions within anterior cingulate cortex and their relationship to autonomic nervous system function. Neuroimage. 2004 Jul; 22(3):1151-6. PMID: 15219587.
        View in: PubMed
      51. Matthews S, Paulus MP, Dimsdale JE. Contribution of functional neuroimaging to understanding neuropsychiatric side effects of interferon in hepatitis C. Psychosomatics. 2004 Jul-Aug; 45(4):281-6. PMID: 15232040.
        View in: PubMed
      52. Camacho A, Matthews S, Dimsdale JE. Use of GHB compounds by HIV-positive individuals. Am J Addict. 2004 Mar-Apr; 13(2):120-7. PMID: 15204663.
        View in: PubMed
      53. Farag NH, Matthews S, Brzezinski E, Nelesen RA, Mills PJ. Relationship between central obesity and cardiovascular hemodynamic indices in postmenopausal women. Fertil Steril. 2004 Feb; 81(2):465-7. PMID: 14967394.
        View in: PubMed
      54. Matthews S, Camacho A, Mills PJ, Dimsdale JE. The internet for medical information about cancer: help or hindrance? Psychosomatics. 2003 Mar-Apr; 44(2):100-3. PMID: 12618531.
        View in: PubMed
      55. Matthews S, Camacho A, Lawson K, Dimsdale JE. Use of herbal medications among 200 psychiatric outpatients: prevalence, patterns of use, and potential dangers. Gen Hosp Psychiatry. 2003 Jan-Feb; 25(1):24-6. PMID: 12583924.
        View in: PubMed
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