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Scott Matthews

TitleClinical Professor
InstitutionUniversity of California San Diego
DepartmentPsychiatry
Address9500 Gilman Drive #9116A
La Jolla CA 92093
Phone619-642-1242
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    Biography

    After receiving his MD from UMDNJ-New Jersey Medical School in 1998, Dr. Matthews completed his internship and residency in psychiatry at UC San Diego, and was Chief Resident at UC San Diego Outpatient Psychiatric Services in his final year of residency. He then completed formal research training in functional brain imaging in mood disorders in UCSD’s Fellowship in Biological Psychiatry and Neuroscience. He is currently Assistant Adjunct Professor of Psychiatry at UC San Diego. Dr. Matthews is actively involved in the American Psychosomatic Society, and has served on several committees of this organization.

    Research Interests

    Dr. Matthews uses fMRI to study the neural substrates involved in mood disorders. He has published several articles that describe the involvement of the anterior cingulate cortex in cognitive processing and autonomic nervous system regulation. Dr. Matthews has received early academic career funding to implement these paradigms in patients with current major depressive disorder. His current work involves using cognitive and emotional tasks during fMRI to probe the neural circuitry involved in major depression and related mood disorders.

    Clinical Focus

    Dr. Matthews is a Staff Psychiatrist at VA San Diego Healthcare System where he is Chief of the Consultation Liaison Division of the VA Psychiatry Service. He also provides care for veterans in one of the VA’s outpatient mood clinics. Dr. Matthews is actively involved in teaching residents and medical students.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Onton JA, Matthews SC, Kang DY, Coleman TP. In-Home Sleep Recordings in Military Veterans With Posttraumatic Stress Disorder Reveal Less REM and Deep Sleep <1 Hz. Front Hum Neurosci. 2018; 12:196. PMID: 29867419.
      View in: PubMed
    2. Huang MX, Nichols S, Robb-Swan A, Angeles-Quinto A, Harrington DL, Drake A, Huang CW, Song T, Diwakar M, Risbrough VB, Matthews S, Clifford R, Cheng CK, Huang JW, Sinha A, Yurgil KA, Ji Z, Lerman I, Lee RR, Baker DG. MEG Working Memory N-Back Task Reveals Functional Deficits in Combat-Related Mild Traumatic Brain Injury. Cereb Cortex. 2018 Apr 13. PMID: 29668852.
      View in: PubMed
    3. Huang MX, Swan AR, Quinto AA, Matthews S, Harrington DL, Nichols S, Bruder BJ, Snook CC, Huang CW, Baker DG, Lee RR. A pilot treatment study for mild traumatic brain injury: Neuroimaging changes detected by MEG after low-intensity pulse-based transcranial electrical stimulation. Brain Inj. 2017; 31(13-14):1951-1963. PMID: 28925734.
      View in: PubMed
    4. Huang MX, Harrington DL, Robb Swan A, Angeles Quinto A, Nichols S, Drake A, Song T, Diwakar M, Huang CW, Risbrough VB, Dale A, Bartsch H, Matthews S, Huang JW, Lee RR, Baker DG. Resting-State Magnetoencephalography Reveals Different Patterns of Aberrant Functional Connectivity in Combat-Related Mild Traumatic Brain Injury. J Neurotrauma. 2017 Apr 01; 34(7):1412-1426. PMID: 27762653.
      View in: PubMed
    5. Atkinson JH, Slater MA, Capparelli EV, Patel SM, Wolfson T, Gamst A, Abramson IS, Wallace MS, Funk SD, Rutledge TR, Wetherell JL, Matthews SC, Zisook S, Garfin SR. A randomized controlled trial of gabapentin for chronic low back pain with and without a radiating component. Pain. 2016 07; 157(7):1499-507. PMID: 26963844; PMCID: PMC5001843 [Available on 07/01/17].
      View in: PubMed, PubMed Central
    6. Buchsbaum MS, Simmons AN, DeCastro A, Farid N, Matthews SC. Clusters of Low (18)F-Fluorodeoxyglucose Uptake Voxels in Combat Veterans with Traumatic Brain Injury and Post-Traumatic Stress Disorder. J Neurotrauma. 2015 Nov 15; 32(22):1736-50. PMID: 25915799.
      View in: PubMed
    7. Schiehser DM, Delano-Wood L, Jak AJ, Matthews SC, Simmons AN, Jacobson MW, Filoteo JV, Bondi MW, Orff HJ, Liu L. Validation of the Modified Fatigue Impact Scale in mild to moderate traumatic brain injury. J Head Trauma Rehabil. 2015 Mar-Apr; 30(2):116-21. PMID: 24413076.
      View in: PubMed
    8. Shu IW, Onton JA, O'Connell RM, Simmons AN, Matthews SC. Combat veterans with comorbid PTSD and mild TBI exhibit a greater inhibitory processing ERP from the dorsal anterior cingulate cortex. Psychiatry Res. 2014 Oct 30; 224(1):58-66. PMID: 25150386.
      View in: PubMed
    9. Wierenga C, Bischoff-Grethe A, Melrose AJ, Grenesko-Stevens E, Irvine Z, Wagner A, Simmons A, Matthews S, Yau WY, Fennema-Notestine C, Kaye WH. Altered BOLD response during inhibitory and error processing in adolescents with anorexia nervosa. PLoS One. 2014; 9(3):e92017. PMID: 24651705; PMCID: PMC3961291.
      View in: PubMed, PubMed Central
    10. Shu IW, Onton JA, Prabhakar N, O'Connell RM, Simmons AN, Matthews SC. Combat veterans with PTSD after mild TBI exhibit greater ERPs from posterior-medial cortical areas while appraising facial features. J Affect Disord. 2014 Feb; 155:234-40. PMID: 24342149.
      View in: PubMed
    11. Oberndorfer T, Simmons A, McCurdy D, Strigo I, Matthews S, Yang T, Irvine Z, Kaye W. Greater anterior insula activation during anticipation of food images in women recovered from anorexia nervosa versus controls. Psychiatry Res. 2013 Nov 30; 214(2):132-41. PMID: 23993362; PMCID: PMC3880160.
      View in: PubMed, PubMed Central
    12. Klabunde M, Acheson DT, Boutelle KN, Matthews SC, Kaye WH. Interoceptive sensitivity deficits in women recovered from bulimia nervosa. Eat Behav. 2013 Dec; 14(4):488-92. PMID: 24183142; PMCID: PMC3817494.
      View in: PubMed, PubMed Central
    13. Matthews SC, Spadoni AD, Lohr JB, Strigo IA, Simmons AN. Diffusion tensor imaging evidence of white matter disruption associated with loss versus alteration of consciousness in warfighters exposed to combat in Operations Enduring and Iraqi Freedom. Psychiatry Res. 2012 Nov 30; 204(2-3):149-54. PMID: 23149025; PMCID: PMC3866101.
      View in: PubMed, PubMed Central
    14. Simmons AN, Flagan TM, Wittmann M, Strigo IA, Matthews SC, Donovan H, Lohr JB, Paulus MP. The effects of temporal unpredictability in anticipation of negative events in combat veterans with PTSD. J Affect Disord. 2013 Apr 25; 146(3):426-32. PMID: 22910447.
      View in: PubMed
    15. Strigo IA, Matthews SC, Simmons AN, Oberndorfer T, Klabunde M, Reinhardt LE, Kaye WH. Altered insula activation during pain anticipation in individuals recovered from anorexia nervosa: evidence of interoceptive dysregulation. Int J Eat Disord. 2013 Jan; 46(1):23-33. PMID: 22836447; PMCID: PMC3507323.
      View in: PubMed, PubMed Central
    16. Paulus MP, Schuckit MA, Tapert SF, Tolentino NJ, Matthews SC, Smith TL, Trim RS, Hall SA, Simmons AN. High versus low level of response to alcohol: evidence of differential reactivity to emotional stimuli. Biol Psychiatry. 2012 Nov 15; 72(10):848-55. PMID: 22608014; PMCID: PMC3433640.
      View in: PubMed, PubMed Central
    17. Matthews S, Spadoni A, Knox K, Strigo I, Simmons A. Combat-exposed war veterans at risk for suicide show hyperactivation of prefrontal cortex and anterior cingulate during error processing. Psychosom Med. 2012 Jun; 74(5):471-5. PMID: 22511726; PMCID: PMC4018224.
      View in: PubMed, PubMed Central
    18. Simmons AN, Fitzpatrick S, Strigo IA, Potterat EG, Johnson DC, Matthews SC, Orden KF, Swain JL, Paulus MP. Altered insula activation in anticipation of changing emotional states: neural mechanisms underlying cognitive flexibility in Special Operations Forces personnel. Neuroreport. 2012 Mar 07; 23(4):234-9. PMID: 22222502.
      View in: PubMed
    19. Simmons AN, Thayer RE, Spadoni AD, Matthews SC, Strigo IA, Tapert SF. The parametric, psychological, neuropsychological, and neuroanatomical properties of self and world evaluation. PLoS One. 2012; 7(2):e31509. PMID: 22348093; PMCID: PMC3278451.
      View in: PubMed, PubMed Central
    20. Schuckit MA, Tapert S, Matthews SC, Paulus MP, Tolentino NJ, Smith TL, Trim RS, Hall S, Simmons A. fMRI differences between subjects with low and high responses to alcohol during a stop signal task. Alcohol Clin Exp Res. 2012 01; 36(1):130-40. PMID: 22003983; PMCID: PMC3253183.
      View in: PubMed, PubMed Central
    21. Simmons AN, Matthews SC, Strigo IA, Baker DG, Donovan HK, Motezadi A, Stein MB, Paulus MP. Altered amygdala activation during face processing in Iraqi and Afghanistani war veterans. Biol Mood Anxiety Disord. 2011 Oct 12; 1(1):6. PMID: 22738183; PMCID: PMC3384263.
      View in: PubMed, PubMed Central
    22. Padula CB, Simmons AN, Matthews SC, Robinson SK, Tapert SF, Schuckit MA, Paulus MP. Alcohol attenuates activation in the bilateral anterior insula during an emotional processing task: a pilot study. Alcohol Alcohol. 2011 Sep-Oct; 46(5):547-52. PMID: 21665869; PMCID: PMC3201697.
      View in: PubMed, PubMed Central
    23. Simmons AN, Matthews SC. Neural circuitry of PTSD with or without mild traumatic brain injury: a meta-analysis. Neuropharmacology. 2012 Feb; 62(2):598-606. PMID: 21420986.
      View in: PubMed
    24. Oberndorfer TA, Kaye WH, Simmons AN, Strigo IA, Matthews SC. Demand-specific alteration of medial prefrontal cortex response during an inhibition task in recovered anorexic women. Int J Eat Disord. 2011 Jan; 44(1):1-8. PMID: 20127942.
      View in: PubMed
    25. Matthews S, Simmons A, Strigo I. The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion. Psychiatry Res. 2011 Jan 30; 191(1):76-9. PMID: 21144713.
      View in: PubMed
    26. Strigo IA, Simmons AN, Matthews SC, Craig AD. The relationship between amygdala activation and passive exposure time to an aversive cue during a continuous performance task. PLoS One. 2010 Nov 29; 5(11):e15093. PMID: 21124739; PMCID: PMC2993966.
      View in: PubMed, PubMed Central
    27. Strigo IA, Simmons AN, Matthews SC, Grimes EM, Allard CB, Reinhardt LE, Paulus MP, Stein MB. Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence. Biol Psychiatry. 2010 Sep 01; 68(5):442-50. PMID: 20553750.
      View in: PubMed
    28. Trim RS, Simmons AN, Tolentino NJ, Hall SA, Matthews SC, Robinson SK, Smith TL, Padula CB, Paulus MP, Tapert SF, Schuckit MA. Acute ethanol effects on brain activation in low- and high-level responders to alcohol. Alcohol Clin Exp Res. 2010 Jul; 34(7):1162-70. PMID: 20477775; PMCID: PMC3774836.
      View in: PubMed, PubMed Central
    29. Matthews SC, Strigo IA, Simmons AN, O'Connell RM, Reinhardt LE, Moseley SA. A multimodal imaging study in U.S. veterans of Operations Iraqi and Enduring Freedom with and without major depression after blast-related concussion. Neuroimage. 2011 Jan; 54 Suppl 1:S69-75. PMID: 20451622.
      View in: PubMed
    30. Matthews SC, Simmons AN, Strigo IA, Arce E, Stein MB, Paulus MP. Escitalopram attenuates posterior cingulate activity during self-evaluation in healthy volunteers. Psychiatry Res. 2010 May 30; 182(2):81-7. PMID: 20418072; PMCID: PMC2882791.
      View in: PubMed, PubMed Central
    31. Camacho A, Simmons AN, Ng B, Matthews SC, Akiskal HS. A factor analysis of different temperament domains in a border region in rural Southern California. J Affect Disord. 2010 Oct; 126(1-2):46-8. PMID: 20392499; PMCID: PMC3782388.
      View in: PubMed, PubMed Central
    32. Strigo IA, Matthews SC, Simmons AN. Right anterior insula hypoactivity during anticipation of homeostatic shifts in major depressive disorder. Psychosom Med. 2010 Apr; 72(3):316-23. PMID: 20100882; PMCID: PMC2884370.
      View in: PubMed, PubMed Central
    33. Yang TT, Simmons AN, Matthews SC, Tapert SF, Frank GK, Max JE, Bischoff-Grethe A, Lansing AE, Brown G, Strigo IA, Wu J, Paulus MP. Adolescents with major depression demonstrate increased amygdala activation. J Am Acad Child Adolesc Psychiatry. 2010 Jan; 49(1):42-51. PMID: 20215925; PMCID: PMC2935523.
      View in: PubMed, PubMed Central
    34. Simmons A, Strigo IA, Matthews SC, Paulus MP, Stein MB. Initial evidence of a failure to activate right anterior insula during affective set shifting in posttraumatic stress disorder. Psychosom Med. 2009 May; 71(4):373-7. PMID: 19398499; PMCID: PMC2888032.
      View in: PubMed, PubMed Central
    35. Yang TT, Simmons AN, Matthews SC, Tapert SF, Frank GK, Bischoff-Grethe A, Lansing AE, Wu J, Brown GG, Paulus MP. Depressed adolescents demonstrate greater subgenual anterior cingulate activity. Neuroreport. 2009 Mar 04; 20(4):440-4. PMID: 19218875; PMCID: PMC2672880.
      View in: PubMed, PubMed Central
    36. Matthews S, Simmons A, Strigo I, Gianaros P, Yang T, Paulus M. Inhibition-related activity in subgenual cingulate is associated with symptom severity in major depression. Psychiatry Res. 2009 Apr 30; 172(1):1-6. PMID: 19239982.
      View in: PubMed
    37. Yang TT, Simmons AN, Matthews SC, Tapert SF, Frank GK, Bischoff-Grethe A, Lansing AE, Wu J, Paulus MP. Adolescent subgenual anterior cingulate activity is related to harm avoidance. Neuroreport. 2009 Jan 07; 20(1):19-23. PMID: 19034055; PMCID: PMC2852645.
      View in: PubMed, PubMed Central
    38. Strigo IA, Simmons AN, Matthews SC, Craig AD, Paulus MP. Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain. Arch Gen Psychiatry. 2008 Nov; 65(11):1275-84. PMID: 18981339; PMCID: PMC2702160.
      View in: PubMed, PubMed Central
    39. Simmons AN, Paulus MP, Thorp SR, Matthews SC, Norman SB, Stein MB. Functional activation and neural networks in women with posttraumatic stress disorder related to intimate partner violence. Biol Psychiatry. 2008 Oct 15; 64(8):681-90. PMID: 18639236; PMCID: PMC2634744.
      View in: PubMed, PubMed Central
    40. Matthews SC, Strigo IA, Simmons AN, Yang TT, Paulus MP. Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder. J Affect Disord. 2008 Nov; 111(1):13-20. PMID: 18603301.
      View in: PubMed
    41. Simmons A, Matthews SC, Feinstein JS, Hitchcock C, Paulus MP, Stein MB. Anxiety vulnerability is associated with altered anterior cingulate response to an affective appraisal task. Neuroreport. 2008 Jul 02; 19(10):1033-7. PMID: 18580574.
      View in: PubMed
    42. Strigo IA, Simmons AN, Matthews SC, Craig AD, Paulus MP. Increased affective bias revealed using experimental graded heat stimuli in young depressed adults: evidence of "emotional allodynia". Psychosom Med. 2008 Apr; 70(3):338-44. PMID: 18378870; PMCID: PMC2742693.
      View in: PubMed, PubMed Central
    43. Yang TT, Simmons AN, Matthews SC, Tapert SF, Bischoff-Grethe A, Frank GK, Arce E, Paulus MP. Increased amygdala activation is related to heart rate during emotion processing in adolescent subjects. Neurosci Lett. 2007 Nov 27; 428(2-3):109-14. PMID: 18029095; PMCID: PMC2171034.
      View in: PubMed, PubMed Central
    44. Simmons A, Matthews SC, Paulus MP, Stein MB. Intolerance of uncertainty correlates with insula activation during affective ambiguity. Neurosci Lett. 2008 Jan 10; 430(2):92-7. PMID: 18079060; PMCID: PMC2692473.
      View in: PubMed, PubMed Central
    45. Matthews SC, Simmons AN, Strigo I, Jang K, Stein MB, Paulus MP. Heritability of anterior cingulate response to conflict: an fMRI study in female twins. Neuroimage. 2007 Oct 15; 38(1):223-7. PMID: 17707125.
      View in: PubMed
    46. Atkinson JH, Slater MA, Capparelli EV, Wallace MS, Zisook S, Abramson I, Matthews SC, Garfin SR. Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial. J Clin Psychopharmacol. 2007 Apr; 27(2):135-42. PMID: 17414235.
      View in: PubMed
    47. Ng B, Camacho A, Simmons A, Matthews SC. Ethnicity and use of alternative products in psychiatric patients. Psychosomatics. 2006 Sep-Oct; 47(5):408-13. PMID: 16959929.
      View in: PubMed
    48. Simmons A, Strigo I, Matthews SC, Paulus MP, Stein MB. Anticipation of aversive visual stimuli is associated with increased insula activation in anxiety-prone subjects. Biol Psychiatry. 2006 Aug 15; 60(4):402-9. PMID: 16919527.
      View in: PubMed
    49. Simmons A, Stein MB, Matthews SC, Feinstein JS, Paulus MP. Affective ambiguity for a group recruits ventromedial prefrontal cortex. Neuroimage. 2006 Jan 15; 29(2):655-61. PMID: 16125977.
      View in: PubMed
    50. Matthews SC, Nelesen RA, Dimsdale JE. Depressive symptoms are associated with increased systemic vascular resistance to stress. Psychosom Med. 2005 Jul-Aug; 67(4):509-13. PMID: 16046361.
      View in: PubMed
    51. Matthews SC, Simmons AN, Arce E, Paulus MP. Dissociation of inhibition from error processing using a parametric inhibitory task during functional magnetic resonance imaging. Neuroreport. 2005 May 12; 16(7):755-60. PMID: 15858420.
      View in: PubMed
    52. Filoteo JV, Maddox WT, Simmons AN, Ing AD, Cagigas XE, Matthews S, Paulus MP. Cortical and subcortical brain regions involved in rule-based category learning. Neuroreport. 2005 Feb 08; 16(2):111-5. PMID: 15671857.
      View in: PubMed
    53. Camacho A, Matthews SC, Murray B, Dimsdale JE. Use of GHB compounds among college students. Am J Drug Alcohol Abuse. 2005; 31(4):601-7. PMID: 16318039.
      View in: PubMed
    54. Hong S, Johnson TA, Farag NH, Guy HJ, Matthews SC, Ziegler MG, Mills PJ. Attenuation of T-lymphocyte demargination and adhesion molecule expression in response to moderate exercise in physically fit individuals. J Appl Physiol (1985). 2005 Mar; 98(3):1057-63. PMID: 15501922.
      View in: PubMed
    55. Simmons A, Matthews SC, Stein MB, Paulus MP. Anticipation of emotionally aversive visual stimuli activates right insula. Neuroreport. 2004 Oct 05; 15(14):2261-5. PMID: 15371746.
      View in: PubMed
    56. Matthews SC, Simmons AN, Lane SD, Paulus MP. Selective activation of the nucleus accumbens during risk-taking decision making. Neuroreport. 2004 Sep 15; 15(13):2123-7. PMID: 15486494.
      View in: PubMed
    57. Matthews SC, Paulus MP, Dimsdale JE. Contribution of functional neuroimaging to understanding neuropsychiatric side effects of interferon in hepatitis C. Psychosomatics. 2004 Jul-Aug; 45(4):281-6. PMID: 15232040.
      View in: PubMed
    58. Matthews SC, Paulus MP, Simmons AN, Nelesen RA, Dimsdale JE. Functional subdivisions within anterior cingulate cortex and their relationship to autonomic nervous system function. Neuroimage. 2004 Jul; 22(3):1151-6. PMID: 15219587.
      View in: PubMed
    59. Camacho A, Matthews SC, Dimsdale JE. Use of GHB compounds by HIV-positive individuals. Am J Addict. 2004 Mar-Apr; 13(2):120-7. PMID: 15204663.
      View in: PubMed
    60. Farag NH, Matthews SC, Brzezinski E, Nelesen RA, Mills PJ. Relationship between central obesity and cardiovascular hemodynamic indices in postmenopausal women. Fertil Steril. 2004 Feb; 81(2):465-7. PMID: 14967394.
      View in: PubMed
    61. Mills PJ, Farag NH, Matthews S, Nelesen RA, Berry CC, Dimsdale JE. Hormone replacement therapy does not affect 24-h ambulatory blood pressure in healthy non-smoking postmenopausal women. Blood Press Monit. 2003 Apr; 8(2):57-61. PMID: 12819556.
      View in: PubMed
    62. Matthews SC, Camacho A, Mills PJ, Dimsdale JE. The internet for medical information about cancer: help or hindrance? Psychosomatics. 2003 Mar-Apr; 44(2):100-3. PMID: 12618531.
      View in: PubMed
    63. Matthews SC, Camacho A, Lawson K, Dimsdale JE. Use of herbal medications among 200 psychiatric outpatients: prevalence, patterns of use, and potential dangers. Gen Hosp Psychiatry. 2003 Jan-Feb; 25(1):24-6. PMID: 12583924.
      View in: PubMed
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