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    Steven Gonias

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPathology
    Address9500 Gilman Drive #0612
    CA La Jolla 92093
    Phone858-534-0455
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      Collapse Research 
      Collapse Research Activities and Funding
      Regulation of Inflammation by the Fibrinolytic System
      NIH/NHLBI R01HL136395Apr 10, 2017 - Mar 31, 2021
      Role: Principal Investigator
      Schwann Cell NMDA Receptor in PNS Injury
      NIH/NINDS R01NS097590Feb 1, 2017 - Jan 31, 2021
      Role: Principal Investigator
      Targeting the Urokinase Receptor in Glioblastoma Multiforme
      NIH/NCI R01CA169096Mar 1, 2013 - Feb 28, 2018
      Role: Principal Investigator
      Alpha2-macroglobulin in peripheral nerve injury
      NIH/NINDS R01NS054671Jul 1, 2007 - Jun 30, 2013
      Role: Principal Investigator
      Gordon Research Conference 2006 Plasminogen Activation
      NIH/NHLBI R13HL083676Sep 30, 2005 - Aug 31, 2006
      Role: Principal Investigator
      Urokinase Receptor-initiated Cell-signaling
      NIH/NCI R01CA094900Apr 1, 2002 - Aug 31, 2012
      Role: Principal Investigator
      Regulation of Signaling Receptor Activity by LRP-1
      NIH/NHLBI R01HL060551Aug 1, 1999 - Dec 31, 2014
      Role: Principal Investigator
      Regulation of Growth Factor Activity by A2 Macroglobulin
      NIH/NCI R01CA053462Aug 1, 1992 - May 31, 2007
      Role: Principal Investigator
      ENVIRONMENTAL MODULATION OF FIBRINOLYSIS INHIBITORS
      NIH/NHLBI R01HL045786Sep 30, 1990 - Jul 31, 1994
      Role: Principal Investigator
      PROTEINASE IN FIBRINOLYSIS AND THROMBOLYTIC THERAPY
      NIH/NHLBI K04HL002272Jul 1, 1989 - Jun 30, 1994
      Role: Principal Investigator
      University of Virginia Cancer Center Support Grant
      NIH P30CA044579Jul 1, 1987 - Jan 31, 2022
      Role: Co-Investigator
      Medical Scientist Training Program
      NIH/NIGMS T32GM007267Jul 1, 1977 - Jun 30, 2020
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Gonias S, Karimi-Mostowfi N, Murray SS, Mantuano E, Gilder AS. Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival. PLoS One. 2017; 12(10):e0186649. PMID: 29088295.
        View in: PubMed
      2. Brifault C, Gilder AS, Laudati E, Banki M, Gonias S. Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuro-inflammation. J Biol Chem. 2017 Sep 28. PMID: 28972143.
        View in: PubMed
      3. Mantuano E, Azmoon P, Brifault C, Banki MA, Gilder AS, Campana WM, Gonias S. Tissue-type plasminogen activator regulates macrophage activation and innate immunity. Blood. 2017 Sep 14; 130(11):1364-1374. PMID: 28684538.
        View in: PubMed
      4. Campana WM, Mantuano E, Azmoon P, Henry K, Banki MA, Kim JH, Pizzo DP, Gonias S. Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells. FASEB J. 2017 Apr; 31(4):1744-1755. PMID: 28073836.
        View in: PubMed
      5. Flütsch A, Henry K, Mantuano E, Lam MS, Shibayama M, Takahashi K, Gonias S, Campana WM. Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells. Neuroreport. 2016 12 14; 27(18):1305-1311. PMID: 27824728.
        View in: PubMed
      6. Hau AM, Leivo MZ, Gilder AS, Hu JJ, Gonias S, Hansel DE. mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer. Cell Signal. 2017 Jan; 29:96-106. PMID: 27777073.
        View in: PubMed
      7. Laudati E, Gilder AS, Lam MS, Misasi R, Sorice M, Gonias S, Mantuano E. The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains. Mol Cell Neurosci. 2016 Oct; 76:42-51. PMID: 27565578.
        View in: PubMed
      8. Mantuano E, Brifault C, Lam MS, Azmoon P, Gilder AS, Gonias S. LDL receptor-related protein-1 regulates NF?B and microRNA-155 in macrophages to control the inflammatory response. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1369-74. PMID: 26787872; PMCID: PMC4747752.
      9. Jones KA, Gilder AS, Lam MS, Du N, Banki MA, Merati A, Pizzo DP, VandenBerg SR, Gonias S. Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature. Neuro Oncol. 2016 May; 18(5):667-78. PMID: 26420897; PMCID: PMC4827039 [Available on 05/01/17].
      10. Mantuano E, Lam MS, Shibayama M, Campana WM, Gonias S. The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. J Cell Sci. 2015 Sep 15; 128(18):3478-88. PMID: 26272917; PMCID: PMC4594737.
      11. Gonias S, Hu J. Urokinase receptor and resistance to targeted anticancer agents. Front Pharmacol. 2015; 6:154. PMID: 26283964; PMCID: PMC4515545.
      12. Hu J, Jo M, Eastman BM, Gilder AS, Bui JD, Gonias S. uPAR induces expression of transforming growth factor ß and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages. Am J Pathol. 2014 Dec; 184(12):3384-93. PMID: 25310970; PMCID: PMC4258500.
      13. Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR, Klemke R, Gonias S, Coppinger JA. Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation. Mol Cell Proteomics. 2015 Jan; 14(1):1-14. PMID: 24997994; PMCID: PMC4288246.
      14. Gupta S, Hau AM, Beach JR, Harwalker J, Mantuano E, Gonias S, Egelhoff TT, Hansel DE. Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion. PLoS One. 2013; 8(11):e81081. PMID: 24312263; PMCID: PMC3842329.
      15. Mantuano E, Lam MS, Gonias S. LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein. J Biol Chem. 2013 Nov 22; 288(47):34009-18. PMID: 24129569; PMCID: PMC3837140.
      16. Gonias S, Campana WM. LDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous system. Am J Pathol. 2014 Jan; 184(1):18-27. PMID: 24128688; PMCID: PMC3873482.
      17. Staudt ND, Jo M, Hu J, Bristow JM, Pizzo DP, Gaultier A, VandenBerg SR, Gonias S. Myeloid cell receptor LRP1/CD91 regulates monocyte recruitment and angiogenesis in tumors. Cancer Res. 2013 Jul 01; 73(13):3902-12. PMID: 23633492; PMCID: PMC3702673.
      18. Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ishikawa T, Feltri ML, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias S, Campana WM. Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. J Neurosci. 2013 Mar 27; 33(13):5590-602. PMID: 23536074; PMCID: PMC3837698.
      19. Fernandez-Castaneda A, Arandjelovic S, Stiles TL, Schlobach RK, Mowen KA, Gonias S, Gaultier A. Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris. J Biol Chem. 2013 Feb 15; 288(7):4538-48. PMID: 23264627; PMCID: PMC3576060.
      20. Stiles TL, Dickendesher TL, Gaultier A, Fernandez-Castaneda A, Mantuano E, Giger RJ, Gonias S. LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin. J Cell Sci. 2013 Jan 01; 126(Pt 1):209-20. PMID: 23132925; PMCID: PMC3603516.
      21. Bristow JM, Reno TA, Jo M, Gonias S, Klemke RL. Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. J Biol Chem. 2013 Jan 04; 288(1):123-31. PMID: 23105102; PMCID: PMC3537006.
      22. Eastman BM, Jo M, Webb DL, Takimoto S, Gonias S. A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen. Cell Signal. 2012 Sep; 24(9):1847-55. PMID: 22617030; PMCID: PMC3383391.
      23. Mantuano E, Henry K, Yamauchi T, Hiramatsu N, Yamauchi K, Orita S, Takahashi K, Lin JH, Gonias S, Campana WM. The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury. J Neurosci. 2011 Sep 21; 31(38):13376-85. PMID: 21940431; PMCID: PMC3188465.
      24. Hu J, Jo M, Cavenee WK, Furnari F, VandenBerg SR, Gonias S. Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15984-9. PMID: 21896743; PMCID: PMC3179096.
      25. Shi Y, Yamauchi T, Gaultier A, Takimoto S, Campana WM, Gonias S. Regulation of cytokine expression by Schwann cells in response to a2-macroglobulin binding to LRP1. J Neurosci Res. 2011 Apr; 89(4):544-51. PMID: 21290408; PMCID: PMC3560970.
      26. Gonias S, Gaultier A, Jo M. Regulation of the urokinase receptor (uPAR) by LDL receptor-related protein-1 (LRP1). Curr Pharm Des. 2011; 17(19):1962-9. PMID: 21711236.
        View in: PubMed
      27. Gaultier A, Simon G, Niessen S, Dix M, Takimoto S, Cravatt BF, Gonias S. LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome. J Proteome Res. 2010 Dec 03; 9(12):6689-95. PMID: 20919742; PMCID: PMC2997161.
      28. Jo M, Eastman BM, Webb DL, Stoletov K, Klemke R, Gonias S. Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. Cancer Res. 2010 Nov 01; 70(21):8948-58. PMID: 20940399; PMCID: PMC2970644.
      29. Gorovoy M, Gaultier A, Campana WM, Firestein GS, Gonias S. Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. J Leukoc Biol. 2010 Oct; 88(4):769-78. PMID: 20610799; PMCID: PMC2974427.
      30. Mantuano E, Jo M, Gonias S, Campana WM. Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration. J Biol Chem. 2010 May 07; 285(19):14259-66. PMID: 20197276; PMCID: PMC2863187.
      31. Green CE, Liu T, Montel V, Hsiao G, Lester RD, Subramaniam S, Gonias S, Klemke RL. Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. PLoS One. 2009 Aug 21; 4(8):e6713. PMID: 19696929; PMCID: PMC2725301.
      32. Gaultier A, Hollister M, Reynolds I, Hsieh EH, Gonias S. LRP1 regulates remodeling of the extracellular matrix by fibroblasts. Matrix Biol. 2010 Jan; 29(1):22-30. PMID: 19699300; PMCID: PMC2818094.
      33. Jo M, Lester RD, Montel V, Eastman B, Takimoto S, Gonias S. Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling. J Biol Chem. 2009 Aug 21; 284(34):22825-33. PMID: 19546228; PMCID: PMC2755690.
      34. Jo M, Takimoto S, Montel V, Gonias S. The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice. Am J Pathol. 2009 Jul; 175(1):190-200. PMID: 19497996; PMCID: PMC2708805.
      35. Shi Y, Mantuano E, Inoue G, Campana WM, Gonias S. Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Sci Signal. 2009 Apr 28; 2(68):ra18. PMID: 19401592; PMCID: PMC2696635.
      36. Gaultier A, Wu X, Le Moan N, Takimoto S, Mukandala G, Akassoglou K, Campana WM, Gonias S. Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. J Cell Sci. 2009 Apr 15; 122(Pt 8):1155-62. PMID: 19299462; PMCID: PMC2714439.
      37. Mantuano E, Inoue G, Li X, Takahashi K, Gaultier A, Gonias S, Campana WM. The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein. J Neurosci. 2008 Nov 05; 28(45):11571-82. PMID: 18987193; PMCID: PMC3837707.
      38. Galliano MF, Toulza E, Jonca N, Gonias S, Serre G, Guerrin M. Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis. PLoS One. 2008 Jul 23; 3(7):e2729. PMID: 18648652; PMCID: PMC2453322.
      39. Mantuano E, Mukandala G, Li X, Campana WM, Gonias S. Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling. J Biol Chem. 2008 Jul 18; 283(29):19904-11. PMID: 18499670; PMCID: PMC2459272.
      40. Gaultier A, Arandjelovic S, Niessen S, Overton CD, Linton MF, Fazio S, Campana WM, Cravatt BF, Gonias S. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood. 2008 Jun 01; 111(11):5316-25. PMID: 18369152; PMCID: PMC2396725.
      41. Gaultier A, Arandjelovic S, Li X, Janes J, Dragojlovic N, Zhou GP, Dolkas J, Myers RR, Gonias S, Campana WM. A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents. J Clin Invest. 2008 Jan; 118(1):161-72. PMID: 18060043; PMCID: PMC2104478.
      42. Stoletov K, Montel V, Lester RD, Gonias S, Klemke R. High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17406-11. PMID: 17954920; PMCID: PMC2077269.
      43. Montel V, Gaultier A, Lester RD, Campana WM, Gonias S. The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development. Cancer Res. 2007 Oct 15; 67(20):9817-24. PMID: 17942912.
        View in: PubMed
      44. Arandjelovic S, Dragojlovic N, Li X, Myers RR, Campana WM, Gonias S. A derivative of the plasma protease inhibitor alpha(2)-macroglobulin regulates the response to peripheral nerve injury. J Neurochem. 2007 Oct; 103(2):694-705. PMID: 17725582.
        View in: PubMed
      45. Lester RD, Jo M, Montel V, Takimoto S, Gonias S. uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells. J Cell Biol. 2007 Jul 30; 178(3):425-36. PMID: 17664334; PMCID: PMC2064849.
      46. Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias S, Cheresh DA, Karin M. Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature. 2007 Apr 05; 446(7136):690-4. PMID: 17377533.
        View in: PubMed
      47. Campana WM, Li X, Dragojlovic N, Janes J, Gaultier A, Gonias S. The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury. J Neurosci. 2006 Oct 25; 26(43):11197-207. PMID: 17065459.
        View in: PubMed
      48. Arandjelovic S, Van Sant CL, Gonias S. Limited mutations in full-length tetrameric human alpha2-macroglobulin abrogate binding of platelet-derived growth factor-BB and transforming growth factor-beta1. J Biol Chem. 2006 Jun 23; 281(25):17061-8. PMID: 16641085.
        View in: PubMed
      49. Gaultier A, Salicioni AM, Arandjelovic S, Gonias S. Regulation of the composition of the extracellular matrix by low density lipoprotein receptor-related protein-1: activities based on regulation of mRNA expression. J Biol Chem. 2006 Mar 17; 281(11):7332-40. PMID: 16407289.
        View in: PubMed
      50. Wu L, Gonias S. The low-density lipoprotein receptor-related protein-1 associates transiently with lipid rafts. J Cell Biochem. 2005 Dec 01; 96(5):1021-33. PMID: 16149055.
        View in: PubMed
      51. Lester RD, Jo M, Campana WM, Gonias S. Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia. J Biol Chem. 2005 Nov 25; 280(47):39273-7. PMID: 16207704.
        View in: PubMed
      52. Li X, Gonias S, Campana WM. Schwann cells express erythropoietin receptor and represent a major target for Epo in peripheral nerve injury. Glia. 2005 Sep; 51(4):254-65. PMID: 15812815.
        View in: PubMed
      53. Mars WM, Jo M, Gonias S. Activation of hepatocyte growth factor by urokinase-type plasminogen activator is ionic strength-dependent. Biochem J. 2005 Aug 15; 390(Pt 1):311-5. PMID: 15869463; PMCID: PMC1184584.
      54. Arandjelovic S, Hall BD, Gonias S. Mutation of lysine 1370 in full-length human alpha2-macroglobulin blocks binding to the low density lipoprotein receptor-related protein-1. Arch Biochem Biophys. 2005 Jun 01; 438(1):29-35. PMID: 15910735.
        View in: PubMed
      55. Mettenburg JM, Arandjelovic S, Gonias S. A chemically modified preparation of alpha2-macroglobulin binds beta-amyloid peptide with increased affinity and inhibits Abeta cytotoxicity. J Neurochem. 2005 Apr; 93(1):53-62. PMID: 15773905.
        View in: PubMed
      56. Jo M, Thomas KS, Marozkina N, Amin TJ, Silva CM, Parsons SJ, Gonias S. Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator. J Biol Chem. 2005 Apr 29; 280(17):17449-57. PMID: 15728176.
        View in: PubMed
      57. Wu L, Arandjelovic S, Gonias S. Effects of low density lipoprotein receptor-related protein-1 on the expression of platelet-derived growth factor beta-receptor in vitro. J Cell Biochem. 2004 Dec 15; 93(6):1169-77. PMID: 15486970.
        View in: PubMed
      58. Gonias S, Wu L, Salicioni AM. Low density lipoprotein receptor-related protein: regulation of the plasma membrane proteome. Thromb Haemost. 2004 Jun; 91(6):1056-64. PMID: 15175790.
        View in: PubMed
      59. Salicioni AM, Gaultier A, Brownlee C, Cheezum MK, Gonias S. Low density lipoprotein receptor-related protein-1 promotes beta1 integrin maturation and transport to the cell surface. J Biol Chem. 2004 Mar 12; 279(11):10005-12. PMID: 14699139.
        View in: PubMed
      60. Jo M, Thomas KS, Wu L, Gonias S. Soluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling. J Biol Chem. 2003 Nov 21; 278(47):46692-8. PMID: 12963722.
        View in: PubMed
      61. Ma Z, Thomas KS, Webb DJ, Moravec R, Salicioni AM, Mars WM, Gonias S. Regulation of Rac1 activation by the low density lipoprotein receptor-related protein. J Cell Biol. 2002 Dec 23; 159(6):1061-70. PMID: 12499359; PMCID: PMC2173989.
      62. Jo M, Thomas KS, O'Donnell DM, Gonias S. Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor. J Biol Chem. 2003 Jan 17; 278(3):1642-6. PMID: 12426305.
        View in: PubMed
      63. Jo M, Thomas KS, Somlyo AV, Somlyo AP, Gonias S. Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration. J Biol Chem. 2002 Apr 05; 277(14):12479-85. PMID: 11805108.
        View in: PubMed