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    Richard Klemke

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPathology
    Address9500 Gilman Drive #0612
    CA La Jolla 92093
    Phone858-822-5610
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      Collapse Research 
      Collapse Research Activities and Funding
      Fingerprinting Invasive Membrane Protrusions to Discover Metastatic Signatures
      NIH/NCI R01CA182495Sep 1, 2014 - Aug 31, 2019
      Role: Principal Investigator
      Vascular communication in metastatic brain colonization
      NIH/NCI R01CA184594Apr 3, 2014 - Feb 28, 2019
      Role: Principal Investigator
      Pre-clinical development of a novel pancreatic cancer chemotherapeutic
      NIH/NCI R43CA180398Sep 1, 2013 - Aug 31, 2014
      Role: Principal Investigator
      Imagining Human Cancer Progression in a Novel Zebrafish Model
      NIH/NCI R01CA129231Aug 1, 2008 - May 31, 2013
      Role: Principal Investigator
      A Proteomics Research Resource for Integrative Biology
      NIH P41RR018522Sep 15, 2003 - Jun 30, 2013
      Role: Co-Investigator
      Mechanisms of Lamellipodia Growth and Retraction
      NIH/NIGMS R01GM068487Aug 1, 2003 - Jul 31, 2012
      Role: Principal Investigator
      Survival Mechanisms of Invasive Carcinoma Cells
      NIH/NCI R01CA097022Jul 1, 2002 - Feb 28, 2018
      Role: Principal Investigator
      Cell Migration Consortium
      NIH U54GM064346Sep 15, 2001 - Jul 31, 2014
      Role: Co-Investigator
      SIGNALING MECHANISMS OF CELL MOTILITY &TUMOR METASTASIS
      NIH/NCI R29CA078493Aug 1, 1998 - Jul 31, 2003
      Role: Principal Investigator
      Comprehensive Biology: Exploiting the Yeast Genome
      NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
      Role: Co-Investigator
      MOLECULAR BASIS OF INTEGRIN MEDIATED CELL MIGRATION
      NIH/NCI F32CA067442Mar 31, 1996
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Fujimura K, Choi S, Wyse M, Strnadel J, Wright T, Klemke R. Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels. J Biol Chem. 2015 Dec 11; 290(50):29907-19. PMID: 26483550.
        View in: PubMed
      2. Agajanian M, Campeau A, Hoover M, Hou A, Brambilla D, Kim SL, Klemke R, Kelber JA. PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFß Responses in Breast Cancer. PLoS One. 2015; 10(8):e0135748. PMID: 26267863.
        View in: PubMed
      3. Fujimura K, Wright T, Strnadel J, Kaushal S, Metildi C, Lowy AM, Bouvet M, Kelber JA, Klemke R. A Hypusine-eIF5A-PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer. Cancer Res. 2014 Nov 15; 74(22):6671-81. PMID: 25261239.
        View in: PubMed
      4. Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR, Klemke R, Gonias SL, Coppinger JA. Proteomic Analysis Reveals a Role for Bcl2-associated Athanogene 3 and Major Vault Protein in Resistance to Apoptosis in Senescent Cells by Regulating ERK1/2 Activation. Mol Cell Proteomics. 2015 Jan; 14(1):1-14. PMID: 24997994.
        View in: PubMed
      5. Choi S, Kelber J, Jiang X, Strnadel J, Fujimura K, Pasillas M, Coppinger J, Klemke R. Procedures for the biochemical enrichment and proteomic analysis of the cytoskeletome. Anal Biochem. 2014 Feb 1; 446:102-7. PMID: 24161902.
        View in: PubMed
      6. Stoletov K, Strnadel J, Zardouzian E, Momiyama M, Park FD, Kelber JA, Pizzo DP, Hoffman R, VandenBerg SR, Klemke R. Role of connexins in metastatic breast cancer and melanoma brain colonization. J Cell Sci. 2013 Feb 15; 126(Pt 4):904-13. PMID: 23321642.
        View in: PubMed
      7. Klemke R, Jiang X, Choi S, Kelber JA. Proteomic and biochemical methods to study the cytoskeletome. Methods Mol Biol. 2013; 1046:203-18. PMID: 23868590.
        View in: PubMed
      8. Bristow JM, Reno TA, Jo M, Gonias SL, Klemke R. Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. J Biol Chem. 2013 Jan 4; 288(1):123-31. PMID: 23105102.
        View in: PubMed
      9. Klemke R. Trespassing cancer cells: 'fingerprinting' invasive protrusions reveals metastatic culprits. Curr Opin Cell Biol. 2012 Oct; 24(5):662-9. PMID: 22980730.
        View in: PubMed
      10. Soman P, Kelber JA, Lee JW, Wright TN, Vecchio KS, Klemke R, Chen S. Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness. Biomaterials. 2012 Oct; 33(29):7064-70. PMID: 22809641.
        View in: PubMed
      11. Kelber JA, Reno T, Kaushal S, Metildi C, Wright T, Stoletov K, Weems JM, Park FD, Mose E, Wang Y, Hoffman RM, Lowy AM, Bouvet M, Klemke R. KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Res. 2012 May 15; 72(10):2554-64. PMID: 22589274.
        View in: PubMed
      12. Wang Y, Klemke R. Proteomics method for identification of pseudopodium phosphotyrosine proteins. Methods Mol Biol. 2012; 757:349-65. PMID: 21909922.
        View in: PubMed
      13. Wang Y, Yang F, Fu Y, Huang X, Wang W, Jiang X, Gritsenko MA, Zhao R, Monore ME, Pertz OC, Purvine SO, Orton DJ, Jacobs JM, Camp DG, Smith RD, Klemke R. Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem. 2011 May 20; 286(20):18190-201. PMID: 21454597.
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      14. Jo M, Eastman BM, Webb DL, Stoletov K, Klemke R, Gonias SL. Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. Cancer Res. 2010 Nov 1; 70(21):8948-58. PMID: 20940399.
        View in: PubMed
      15. Jin H, Garmy-Susini B, Avraamides CJ, Stoletov K, Klemke R, Varner JA. A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting. Blood. 2010 Dec 16; 116(25):5773-83. PMID: 20826718.
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      16. Kelber JA, Klemke R. PEAK1, a novel kinase target in the fight against cancer. Oncotarget. 2010 Jul; 1(3):219-23. PMID: 21301050.
        View in: PubMed
      17. Stoletov K, Kato H, Zardouzian E, Kelber J, Yang J, Shattil S, Klemke R. Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci. 2010 Jul 1; 123(Pt 13):2332-41. PMID: 20530574.
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      18. Wang Y, Kelber JA, Tran Cao HS, Cantin GT, Lin R, Wang W, Kaushal S, Bristow JM, Edgington TS, Hoffman RM, Bouvet M, Yates JR, Klemke R. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):10920-5. PMID: 20534451.
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      19. Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M, Klemke R, Vogt PK, Arnold L, Wrasidlo W, Cheresh DA. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4299-304. PMID: 20154271.
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      20. Green CE, Liu T, Montel V, Hsiao G, Lester RD, Subramaniam S, Gonias SL, Klemke R. Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. PLoS One. 2009; 4(8):e6713. PMID: 19696929.
        View in: PubMed
      21. Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum JL, Klemke R, Miller YI. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res. 2009 Apr 24; 104(8):952-60. PMID: 19265037.
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      22. Wrasidlo W, Mielgo A, Torres VA, Barbero S, Stoletov K, Suyama TL, Klemke R, Gerwick WH, Carson DA, Stupack DG. The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2313-8. PMID: 18268346.
        View in: PubMed
      23. Pertz OC, Wang Y, Yang F, Wang W, Gay LJ, Gristenko MA, Clauss TR, Anderson DJ, Liu T, Auberry KJ, Camp DG, Smith RD, Klemke R. Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1931-6. PMID: 18245386.
        View in: PubMed
      24. Stoletov K, Montel V, Lester RD, Gonias SL, Klemke R. High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17406-11. PMID: 17954920.
        View in: PubMed
      25. Wang Y, Klemke R. PhosphoBlast, a computational tool for comparing phosphoprotein signatures among large datasets. Mol Cell Proteomics. 2008 Jan; 7(1):145-62. PMID: 17934212.
        View in: PubMed
      26. Wang Y, Ding SJ, Wang W, Yang F, Jacobs JM, Camp D, Smith RD, Klemke R. Methods for pseudopodia purification and proteomic analysis. Sci STKE. 2007 Sep 8; 2007(400):pl4. PMID: 17712138.
        View in: PubMed
      27. Wang Y, Ding SJ, Wang W, Jacobs JM, Qian WJ, Moore RJ, Yang F, Camp DG, Smith RD, Klemke R. Profiling signaling polarity in chemotactic cells. Proc Natl Acad Sci U S A. 2007 May 15; 104(20):8328-33. PMID: 17494752.
        View in: PubMed
      28. Wang Y, Klemke R. Biochemical purification of pseudopodia from migratory cells. Methods Mol Biol. 2007; 370:55-66. PMID: 17416987.
        View in: PubMed
      29. Wang Y, Hanley R, Klemke R. Computational methods for comparison of large genomic and proteomic datasets reveal protein markers of metastatic cancer. J Proteome Res. 2006 Apr; 5(4):907-15. PMID: 16602698.
        View in: PubMed
      30. Chodniewicz D, Klemke R. Guiding cell migration through directed extension and stabilization of pseudopodia. Exp Cell Res. 2004 Nov 15; 301(1):31-7. PMID: 15501442.
        View in: PubMed
      31. Kain KH, Gooch S, Klemke R. Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion. Oncogene. 2003 Sep 4; 22(38):6071-80. PMID: 12955086.
        View in: PubMed
      32. Brahmbhatt AA, Klemke R. ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis. J Biol Chem. 2003 Apr 11; 278(15):13016-25. PMID: 12571246.
        View in: PubMed
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