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    Jeff Hasty

    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0368
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Network-Driven Dynamics of Replicative Aging
      NIH/NIA R01AG056440Aug 1, 2017 - May 31, 2022
      Role: Co-Principal Investigator
      The q-bio Summer School
      NIH/NIGMS R25GM105608Apr 1, 2013 - Jan 31, 2017
      Role: Principal Investigator
      Delays and variability in single-cell NFkB signaling
      NIH/NIGMS R01GM089976May 1, 2010 - Apr 30, 2014
      Role: Principal Investigator
      San Diego Center for Systems Biology: From Maps to Models
      NIH/NIGMS P50GM085764Jul 1, 2008 - May 31, 2019
      Role: Principal Investigator
      Metabolic Control in a Dynamic Environment
      NIH/NIGMS R01GM079333Dec 1, 2006 - Apr 30, 2015
      Role: Principal Investigator
      Engineered gene circuits for basic science and biotechnology
      NIH/NIGMS R01GM069811Dec 1, 2003 - Jul 31, 2020
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Didovyk A, Tonooka T, Tsimring L, Hasty J. Rapid and Scalable Preparation of Bacterial Lysates for Cell-Free Gene Expression. ACS Synth Biol. 2017 Aug 21. PMID: 28795570.
        View in: PubMed
      2. Baumgart L, Mather W, Hasty J. Synchronized DNA cycling across a bacterial population. Nat Genet. 2017 Aug; 49(8):1282-1285. PMID: 28692067.
        View in: PubMed
      3. Scott SR, Din MO, Bittihn P, Xiong L, Tsimring LS, Hasty J. A stabilized microbial ecosystem of self-limiting bacteria using synthetic quorum-regulated lysis. Nat Microbiol. 2017 Jun 12; 2:17083. PMID: 28604679.
        View in: PubMed
      4. Bittihn P, Hasty J, Tsimring LS. Suppression of Beneficial Mutations in Dynamic Microbial Populations. Phys Rev Lett. 2017 Jan 13; 118(2):028102. PMID: 28128631.
        View in: PubMed
      5. Rodriguez-Lujan I, Hasty J, Huerta R. FBB: a fast Bayesian-bound tool to calibrate RNA-seq aligners. Bioinformatics. 2017 Jan 15; 33(2):210-218. PMID: 27663496.
        View in: PubMed
      6. Steiner PJ, Williams RJ, Hasty J, Tsimring LS. Criticality and Adaptivity in Enzymatic Networks. Biophys J. 2016 Sep 06; 111(5):1078-87. PMID: 27602735.
        View in: PubMed
      7. Didovyk A, Borek B, Tsimring L, Hasty J. Transcriptional regulation with CRISPR-Cas9: principles, advances, and applications. Curr Opin Biotechnol. 2016 Aug; 40:177-184. PMID: 27344519; PMCID: PMC4975649 [Available on 08/01/17].
      8. Scott SR, Hasty J. Quorum Sensing Communication Modules for Microbial Consortia. ACS Synth Biol. 2016 Sep 16; 5(9):969-77. PMID: 27172092.
        View in: PubMed
      9. Borek B, Hasty J, Tsimring L. Turing Patterning Using Gene Circuits with Gas-Induced Degradation of Quorum Sensing Molecules. PLoS One. 2016; 11(5):e0153679. PMID: 27148743; PMCID: PMC4858293.
      10. Didovyk A, Borek B, Hasty J, Tsimring L. Orthogonal Modular Gene Repression in Escherichia coli Using Engineered CRISPR/Cas9. ACS Synth Biol. 2016 Jan 15; 5(1):81-8. PMID: 26390083.
        View in: PubMed
      11. Luke CS, Selimkhanov J, Baumgart L, Cohen SE, Golden SS, Cookson NA, Hasty J. A Microfluidic Platform for Long-Term Monitoring of Algae in a Dynamic Environment. ACS Synth Biol. 2016 Jan 15; 5(1):8-14. PMID: 26332284.
        View in: PubMed
      12. Didovyk A, Kanakov OI, Ivanchenko MV, Hasty J, Huerta R, Tsimring L. Distributed classifier based on genetically engineered bacterial cell cultures. ACS Synth Biol. 2015 Jan 16; 4(1):72-82. PMID: 25349924; PMCID: PMC4304444.
      13. Cohen SE, Erb ML, Selimkhanov J, Dong G, Hasty J, Pogliano J, Golden SS. Dynamic localization of the cyanobacterial circadian clock proteins. Curr Biol. 2014 Aug 18; 24(16):1836-44. PMID: 25127213; PMCID: PMC4139467.
      14. Prindle A, Selimkhanov J, Li H, Razinkov I, Tsimring LS, Hasty J. Rapid and tunable post-translational coupling of genetic circuits. Nature. 2014 Apr 17; 508(7496):387-91. PMID: 24717442; PMCID: PMC4142690.
      15. Razinkov IA, Baumgartner BL, Bennett MR, Tsimring LS, Hasty J. Measuring competitive fitness in dynamic environments. J Phys Chem B. 2013 Oct 24; 117(42):13175-81. PMID: 23841812; PMCID: PMC3808460.
      16. Longo DM, Selimkhanov J, Kearns JD, Hasty J, Hoffmann A, Tsimring LS. Dual delayed feedback provides sensitivity and robustness to the NF-?B signaling module. PLoS Comput Biol. 2013; 9(6):e1003112. PMID: 23825938; PMCID: PMC3694842.
      17. Kolnik M, Tsimring LS, Hasty J. Vacuum-assisted cell loading enables shear-free mammalian microfluidic culture. Lab Chip. 2012 Nov 21; 12(22):4732-7. PMID: 22961584; PMCID: PMC3510264.
      18. Prindle A, Hasty J. Making gene circuits sing. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):16758-9. PMID: 23027956; PMCID: PMC3479459.
      19. Prindle A, Selimkhanov J, Danino T, Samayoa P, Goldberg A, Bhatia SN, Hasty J. Genetic Circuits in Salmonella typhimurium. ACS Synth Biol. 2012 Oct 19; 1(10):458-464. PMID: 23097749.
        View in: PubMed
      20. Mather WH, Hasty J, Tsimring LS. Fast stochastic algorithm for simulating evolutionary population dynamics. Bioinformatics. 2012 May 01; 28(9):1230-8. PMID: 22437850; PMCID: PMC3338019.
      21. Cookson NA, Mather WH, Danino T, Mondragón-Palomino O, Williams RJ, Tsimring LS, Hasty J. Queueing up for enzymatic processing: correlated signaling through coupled degradation. Mol Syst Biol. 2011 Dec 20; 7:561. PMID: 22186735; PMCID: PMC3737734.
      22. Prindle A, Samayoa P, Razinkov I, Danino T, Tsimring LS, Hasty J. A sensing array of radically coupled genetic 'biopixels'. Nature. 2011 Dec 18; 481(7379):39-44. PMID: 22178928; PMCID: PMC3259005.
      23. Baumgartner BL, Bennett MR, Ferry M, Johnson TL, Tsimring LS, Hasty J. Antagonistic gene transcripts regulate adaptation to new growth environments. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21087-92. PMID: 22160690; PMCID: PMC3248483.
      24. Selimkhanov J, Hasty J, Tsimring LS. Recent advances in single-cell studies of gene regulation. Curr Opin Biotechnol. 2012 Feb; 23(1):34-40. PMID: 22154220; PMCID: PMC3273644.
      25. Mather WH, Hasty J, Tsimring LS, Williams RJ. Factorized time-dependent distributions for certain multiclass queueing networks and an application to enzymatic processing networks. Queueing Syst. 2011 Dec; 69(3-4):313-328. PMID: 24596432.
        View in: PubMed
      26. Danino T, Volfson D, Bhatia SN, Tsimring L, Hasty J. In-silico patterning of vascular mesenchymal cells in three dimensions. PLoS One. 2011; 6(5):e20182. PMID: 21633504; PMCID: PMC3102094.
      27. Ferry MS, Razinkov IA, Hasty J. Microfluidics for synthetic biology: from design to execution. Methods Enzymol. 2011; 497:295-372. PMID: 21601093; PMCID: PMC4836382.
      28. Mather WH, Cookson NA, Hasty J, Tsimring LS, Williams RJ. Correlation resonance generated by coupled enzymatic processing. Biophys J. 2010 Nov 17; 99(10):3172-81. PMID: 21081064; PMCID: PMC2980735.
      29. Prindle A, Hasty J. Biochemistry. Stochastic emergence of groupthink. Science. 2010 May 21; 328(5981):987-8. PMID: 20489014; PMCID: PMC2931587.
      30. Mather W, Mondragón-Palomino O, Danino T, Hasty J, Tsimring LS. Streaming instability in growing cell populations. Phys Rev Lett. 2010 May 21; 104(20):208101. PMID: 20867071; PMCID: PMC2947335.
      31. Danino T, Mondragón-Palomino O, Tsimring L, Hasty J. A synchronized quorum of genetic clocks. Nature. 2010 Jan 21; 463(7279):326-30. PMID: 20090747; PMCID: PMC2838179.
      32. Cookson NA, Tsimring LS, Hasty J. The pedestrian watchmaker: genetic clocks from engineered oscillators. FEBS Lett. 2009 Dec 17; 583(24):3931-7. PMID: 19903483; PMCID: PMC2921805.
      33. Cookson NA, Cookson SW, Tsimring LS, Hasty J. Cell cycle-dependent variations in protein concentration. Nucleic Acids Res. 2010 May; 38(8):2676-81. PMID: 20019065; PMCID: PMC2860113.
      34. Mather W, Bennett MR, Hasty J, Tsimring LS. Delay-induced degrade-and-fire oscillations in small genetic circuits. Phys Rev Lett. 2009 Feb 13; 102(6):068105. PMID: 19257639; PMCID: PMC2924583.
      35. Stricker J, Cookson S, Bennett MR, Mather WH, Tsimring LS, Hasty J. A fast, robust and tunable synthetic gene oscillator. Nature. 2008 Nov 27; 456(7221):516-9. PMID: 18971928.
        View in: PubMed
      36. Volfson D, Cookson S, Hasty J, Tsimring LS. Biomechanical ordering of dense cell populations. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15346-51. PMID: 18832176; PMCID: PMC2563119.
      37. Bennett MR, Pang WL, Ostroff NA, Baumgartner BL, Nayak S, Tsimring LS, Hasty J. Metabolic gene regulation in a dynamically changing environment. Nature. 2008 Aug 28; 454(7208):1119-22. PMID: 18668041; PMCID: PMC2654342.
      38. Lu T, Shen T, Bennett MR, Wolynes PG, Hasty J. Phenotypic variability of growing cellular populations. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):18982-7. PMID: 18025471; PMCID: PMC2141894.
      39. Grilly C, Stricker J, Pang WL, Bennett MR, Hasty J. A synthetic gene network for tuning protein degradation in Saccharomyces cerevisiae. Mol Syst Biol. 2007; 3:127. PMID: 17667949; PMCID: PMC1943424.
      40. Bennett MR, Volfson D, Tsimring L, Hasty J. Transient dynamics of genetic regulatory networks. Biophys J. 2007 May 15; 92(10):3501-12. PMID: 17350994; PMCID: PMC1853127.
      41. Longo D, Hasty J. Dynamics of single-cell gene expression. Mol Syst Biol. 2006; 2:64. PMID: 17130866; PMCID: PMC1682029.
      42. Lu T, Shen T, Zong C, Hasty J, Wolynes PG. Statistics of cellular signal transduction as a race to the nucleus by multiple random walkers in compartment/phosphorylation space. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16752-7. PMID: 17071742; PMCID: PMC1636527.
      43. Tsimring LS, Volfson D, Hasty J. Stochastically driven genetic circuits. Chaos. 2006 Jun; 16(2):026103. PMID: 16822035.
        View in: PubMed
      44. Lu T, Hasty J, Wolynes PG. Effective temperature in stochastic kinetics and gene networks. Biophys J. 2006 Jul 01; 91(1):84-94. PMID: 16617067; PMCID: PMC1479063.
      45. Volfson D, Marciniak J, Blake WJ, Ostroff N, Tsimring LS, Hasty J. Origins of extrinsic variability in eukaryotic gene expression. Nature. 2006 Feb 16; 439(7078):861-4. PMID: 16372021.
        View in: PubMed
      46. Cookson S, Ostroff N, Pang WL, Volfson D, Hasty J. Monitoring dynamics of single-cell gene expression over multiple cell cycles. Mol Syst Biol. 2005; 1:2005.0024. PMID: 16729059; PMCID: PMC1681470.
      47. Bratsun D, Volfson D, Tsimring LS, Hasty J. Delay-induced stochastic oscillations in gene regulation. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14593-8. PMID: 16199522; PMCID: PMC1253555.
      48. Lu T, Volfson D, Tsimring L, Hasty J. Cellular growth and division in the Gillespie algorithm. Syst Biol (Stevenage). 2004 Jun; 1(1):121-8. PMID: 17052122.
        View in: PubMed
      49. Hasty J. Design then mutate. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16516-8. PMID: 12486244; PMCID: PMC139174.
      50. Hasty J, McMillen D, Collins JJ. Engineered gene circuits. Nature. 2002 Nov 14; 420(6912):224-30. PMID: 12432407.
        View in: PubMed