Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Adam Engler

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    DepartmentBioengineering
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    Phone858-246-0678
    vCardDownload vCard

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Blice-Baum AC, Zambon AC, Kaushik G, Viswanathan MC, Engler A, Bodmer R, Cammarato A. Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age-associated functional decline. Aging Cell. 2017 Feb; 16(1):93-103. PMID: 28090761.
        View in: PubMed
      2. Gibbons MC, Singh A, Anakwenze O, Cheng T, Pomerantz M, Schenk S, Engler A, Ward SR. Histological Evidence of Muscle Degeneration in Advanced Human Rotator Cuff Disease. J Bone Joint Surg Am. 2017 Feb 01; 99(3):190-199. PMID: 28145949.
        View in: PubMed
      3. Sessions AO, Kaushik G, Parker S, Raedschelders K, Bodmer R, Van Eyk JE, Engler A. Extracellular matrix downregulation in the Drosophila heart preserves contractile function and improves lifespan. Matrix Biol. 2016 Oct 25. PMID: 27793636.
        View in: PubMed
      4. Holle AW, McIntyre AJ, Kehe J, Wijesekara P, Young JL, Vincent LG, Engler A. High content image analysis of focal adhesion-dependent mechanosensitive stem cell differentiation. Integr Biol (Camb). 2016 Oct 10; 8(10):1049-1058. PMID: 27723854.
        View in: PubMed
      5. Thomas KA, Gibbons MC, Lane JG, Singh A, Ward SR, Engler A. Rotator cuff tear state modulates self-renewal and differentiation capacity of human skeletal muscle progenitor cells. J Orthop Res. 2016 Oct 04. PMID: 27699827.
        View in: PubMed
      6. Engler A, Parot P, Pellequer JL. Sixth International AFM BioMed Conference on AFM in life sciences and medicine, December 13 to 17, 2014, San Diego, California. J Mol Recognit. 2016 Sep; 29(9):404-5. PMID: 27502838.
        View in: PubMed
      7. Sessions AO, Engler A. Mechanical Regulation of Cardiac Aging in Model Systems. Circ Res. 2016 May 13; 118(10):1553-62. PMID: 27174949.
        View in: PubMed
      8. Gibbons MC, Sato EJ, Bachasson D, Cheng T, Azimi H, Schenk S, Engler A, Singh A, Ward SR. Muscle architectural changes after Massive human rotator cuff tear. J Orthop Res. 2016 Apr 6. PMID: 27061583.
        View in: PubMed
      9. Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler A, Fu XD, Muotri AR, Almutairi A. Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3185-90. PMID: 26944080.
        View in: PubMed
      10. Ondeck MG, Engler A. Mechanical Characterization of a Dynamic and Tunable Methacrylated Hyaluronic Acid Hydrogel. J Biomech Eng. 2016 Feb 1; 138(2). PMID: 26746491.
        View in: PubMed
      11. Happe CL, Engler A. Mechanical Forces Reshape Differentiation Cues That Guide Cardiomyogenesis. Circ Res. 2016 Jan 22; 118(2):296-310. PMID: 26838315.
        View in: PubMed
      12. Fuhrmann A, Engler A. The Cytoskeleton Regulates Cell Attachment Strength. Biophys J. 2015 Jul 7; 109(1):57-65. PMID: 26153702.
        View in: PubMed
      13. Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler A, Xiang YK, Bers DM, Wu JC. Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised ß-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell. 2015 Jul 2; 17(1):89-100. PMID: 26095046.
        View in: PubMed
      14. Kaushik G, Spenlehauer A, Sessions AO, Trujillo AS, Fuhrmann A, Fu Z, Venkatraman V, Pohl D, Tuler J, Wang M, Lakatta EG, Ocorr K, Bodmer R, Bernstein SI, Van Eyk JE, Cammarato A, Engler A. Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart. Sci Transl Med. 2015 Jun 17; 7(292):292ra99. PMID: 26084806.
        View in: PubMed
      15. Wen JH, Choi O, Taylor-Weiner H, Fuhrmann A, Karpiak JV, Almutairi A, Engler A. Haptotaxis is cell type specific and limited by substrate adhesiveness. Cell Mol Bioeng. 2015 Dec 1; 8(4):530-542. PMID: 26640598.
        View in: PubMed
      16. Meyer GA, Gibbons MC, Sato E, Lane JG, Ward SR, Engler A. Epimuscular Fat in the Human Rotator Cuff Is a Novel Beige Depot. Stem Cells Transl Med. 2015 Jul; 4(7):764-74. PMID: 25999520.
        View in: PubMed
      17. Taylor-Weiner H, Ravi N, Engler A. Traction forces mediated by integrin signaling are necessary for definitive endoderm specification. J Cell Sci. 2015 May 15; 128(10):1961-8. PMID: 25908864.
        View in: PubMed
      18. Hribar KC, Finlay D, Ma X, Qu X, Ondeck MG, Chung PH, Zanella F, Engler A, Sheikh F, Vuori K, Chen SC. Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture. Lab Chip. 2015 Jun 7; 15(11):2412-8. PMID: 25900329.
        View in: PubMed
      19. Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor SS, Engler A, Yang J. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol. 2015 May; 17(5):678-88. PMID: 25893917.
        View in: PubMed
      20. Jun I, Lee YB, Choi YS, Engler A, Park H, Shin H. Transfer stamping of human mesenchymal stem cell patches using thermally expandable hydrogels with tunable cell-adhesive properties. Biomaterials. 2015 Jun; 54:44-54. PMID: 25907038.
        View in: PubMed
      21. Viswanathan P, Ondeck MG, Chirasatitsin S, Ngamkham K, Reilly GC, Engler A, Battaglia G. 3D surface topology guides stem cell adhesion and differentiation. Biomaterials. 2015 Jun; 52:140-7. PMID: 25818420.
        View in: PubMed
      22. Fuhrmann A, Engler A. Acute shear stress direction dictates adherent cell remodeling and verifies shear profile of spinning disk assays. Phys Biol. 2015; 12(1):016011. PMID: 25619322.
        View in: PubMed
      23. Meyer GA, Farris AL, Sato E, Gibbons M, Lane JG, Ward SR, Engler A. Muscle progenitor cell regenerative capacity in the torn rotator cuff. J Orthop Res. 2015 Mar; 33(3):421-9. PMID: 25410765.
        View in: PubMed
      24. Young JL, Kretchmer K, Ondeck MG, Zambon AC, Engler A. Mechanosensitive kinases regulate stiffness-induced cardiomyocyte maturation. Sci Rep. 2014; 4:6425. PMID: 25236849.
        View in: PubMed
      25. Hribar KC, Choi YS, Ondeck M, Engler A, Chen S. Digital Plasmonic Patterning for Localized Tuning of Hydrogel Stiffness. Adv Funct Mater. 2014 Aug 20; 24(31):4922-4926. PMID: 26120293.
        View in: PubMed
      26. Thomas K, Engler A, Meyer GA. Extracellular matrix regulation in the muscle satellite cell niche. Connect Tissue Res. 2015 Feb; 56(1):1-8. PMID: 25047058.
        View in: PubMed
      27. Wen JH, Vincent LG, Fuhrmann A, Choi YS, Hribar KC, Taylor-Weiner H, Chen S, Engler A. Interplay of matrix stiffness and protein tethering in stem cell differentiation. Nat Mater. 2014 Oct; 13(10):979-87. PMID: 25108614.
        View in: PubMed
      28. Fuhrmann A, Li J, Chien S, Engler A. Cation type specific cell remodeling regulates attachment strength. PLoS One. 2014; 9(7):e102424. PMID: 25014042.
        View in: PubMed
      29. Murphy WL, McDevitt TC, Engler A. Materials as stem cell regulators. Nat Mater. 2014 May 21; 13(6):547-57. PMID: 24845994.
        View in: PubMed
      30. Nishimura M, Kumsta C, Kaushik G, Diop SB, Ding Y, Bisharat-Kernizan J, Catan H, Cammarato A, Ross RS, Engler A, Bodmer R, Hansen M, Ocorr K. A dual role for integrin-linked kinase and ß1-integrin in modulating cardiac aging. Aging Cell. 2014 Jun; 13(3):431-40. PMID: 24400780.
        View in: PubMed
      31. Kaushik G, Engler A. From stem cells to cardiomyocytes: the role of forces in cardiac maturation, aging, and disease. Prog Mol Biol Transl Sci. 2014; 126:219-42. PMID: 25081620.
        View in: PubMed
      32. Engler A, Kumar S. Preface. Prog Mol Biol Transl Sci. 2014; 126:xiii-xiv. PMID: 25081625.
        View in: PubMed
      33. Cozhimuttam Viswanathan M, Kaushik G, Engler A, Lehman W, Cammarato A. A Drosophila melanogaster Model of Diastolic Dysfunction and Cardiomyopathy Based on Impaired Troponin-T Function. Circ Res. 2014 Jan 17; 114(2):e6-e17. PMID: 24221941.
        View in: PubMed
      34. Holle AW, Tang X, Vijayraghavan D, Vincent LG, Fuhrmann A, Choi YS, Del Álamo JC, Engler A. In situ mechanotransduction via vinculin regulates stem cell differentiation. Stem Cells. 2013 Nov; 31(11):2467-77. PMID: 23897765.
        View in: PubMed
      35. Taylor-Weiner H, Schwarzbauer JE, Engler A. Defined extracellular matrix components are necessary for definitive endoderm induction. Stem Cells. 2013 Oct; 31(10):2084-94. PMID: 23766144.
        View in: PubMed
      36. Rao N, Grover GN, Vincent LG, Evans SC, Choi YS, Spencer KH, Hui EE, Engler A, Christman KL. A co-culture device with a tunable stiffness to understand combinatorial cell-cell and cell-matrix interactions. Integr Biol (Camb). 2013 Nov; 5(11):1344-54. PMID: 24061208.
        View in: PubMed
      37. Young DA, Choi YS, Engler A, Christman KL. Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue. Biomaterials. 2013 Nov; 34(34):8581-8. PMID: 23953825.
        View in: PubMed
      38. Vincent LG, Engler A. Stem cell differentiation: Post-degradation forces kick in. Nat Mater. 2013 May; 12(5):384-6. PMID: 23603879.
        View in: PubMed
      39. Young JL, Tuler J, Braden R, Schüp-Magoffin P, Schaefer J, Kretchmer K, Christman KL, Engler A. In vivo response to dynamic hyaluronic acid hydrogels. Acta Biomater. 2013 Jul; 9(7):7151-7. PMID: 23523533.
        View in: PubMed
      40. Vincent LG, Choi YS, Alonso-Latorre B, del Álamo JC, Engler A. Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength. Biotechnol J. 2013 Apr; 8(4):472-84. PMID: 23390141.
        View in: PubMed
      41. Joshi-Barr S, Karpiak JV, Ner Y, Wen JH, Engler A, Almutairi A. Density gradient multilayered polymerization (DGMP): a novel technique for creating multi-compartment, customizable scaffolds for tissue engineering. J Vis Exp. 2013; (72). PMID: 23426045.
        View in: PubMed
      42. Kiang JD, Wen JH, del Álamo JC, Engler A. Dynamic and reversible surface topography influences cell morphology. J Biomed Mater Res A. 2013 Aug; 101(8):2313-21. PMID: 23355509.
        View in: PubMed
      43. Viswanathan P, Chirasatitsin S, Ngamkham K, Engler A, Battaglia G. Cell instructive microporous scaffolds through interface engineering. J Am Chem Soc. 2012 Dec 12; 134(49):20103-9. PMID: 23163574.
        View in: PubMed
      44. Control of stem cell fate and function by engineering physical microenvironments. Integr Biol (Camb). 2012 Sep; 4(9):1008-18. PMID: 23077731.
        View in: PubMed
      45. Kaushik G, Zambon AC, Fuhrmann A, Bernstein SI, Bodmer R, Engler A, Cammarato A. Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction. J Cell Mol Med. 2012 Aug; 16(8):1656-62. PMID: 22225769.
        View in: PubMed
      46. Choi YS, Vincent LG, Lee AR, Kretchmer KC, Chirasatitsin S, Dobke MK, Engler A. The alignment and fusion assembly of adipose-derived stem cells on mechanically patterned matrices. Biomaterials. 2012 Oct; 33(29):6943-51. PMID: 22800539.
        View in: PubMed
      47. Choi YS, Vincent LG, Lee AR, Dobke MK, Engler A. Mechanical derivation of functional myotubes from adipose-derived stem cells. Biomaterials. 2012 Mar; 33(8):2482-91. PMID: 22197570.
        View in: PubMed
      48. Kaushik G, Fuhrmann A, Cammarato A, Engler A. In situ mechanical analysis of myofibrillar perturbation and aging on soft, bilayered Drosophila myocardium. Biophys J. 2011 Dec 7; 101(11):2629-37. PMID: 22261050.
        View in: PubMed
      49. Battaglia G, LoPresti C, Massignani M, Warren NJ, Madsen J, Forster S, Vasilev C, Hobbs JK, Armes SP, Chirasatitsin S, Engler A. Wet nanoscale imaging and testing of polymersomes. Small. 2011 Jul 18; 7(14):2010-5. PMID: 21695783.
        View in: PubMed
      50. Holle AW, Engler A. More than a feeling: discovering, understanding, and influencing mechanosensing pathways. Curr Opin Biotechnol. 2011 Oct; 22(5):648-54. PMID: 21536426.
        View in: PubMed
      51. LoPresti C, Massignani M, Fernyhough C, Blanazs A, Ryan AJ, Madsen J, Warren NJ, Armes SP, Lewis AL, Chirasatitsin S, Engler A, Battaglia G. Controlling polymersome surface topology at the nanoscale by membrane confined polymer/polymer phase separation. ACS Nano. 2011 Mar 22; 5(3):1775-84. PMID: 21344879.
        View in: PubMed
      52. Tse JR, Engler A. Stiffness gradients mimicking in vivo tissue variation regulate mesenchymal stem cell fate. PLoS One. 2011; 6(1):e15978. PMID: 21246050.
        View in: PubMed
      53. Young JL, Engler A. Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro. Biomaterials. 2011 Feb; 32(4):1002-9. PMID: 21071078.
        View in: PubMed
      54. Tse JR, Engler A. Preparation of hydrogel substrates with tunable mechanical properties. Curr Protoc Cell Biol. 2010 Jun; Chapter 10:Unit 10.16. PMID: 20521229.
        View in: PubMed
      55. Chirasatitsin S, Engler A. Detecting cell-adhesive sites in extracellular matrix using force spectroscopy mapping. J Phys Condens Matter. 2010 May 19; 22(19):194102. PMID: 21152375.
        View in: PubMed
      56. Holle AW, Engler A. Cell rheology: Stressed-out stem cells. Nat Mater. 2010 Jan; 9(1):4-6. PMID: 20019660.
        View in: PubMed
      57. Flores-Merino MV, Chirasatitsin S, Lopresti C, Reilly GC, Battaglia G, Engler A. Nanoscopic mechanical anisotropy in hydrogel surfaces. Soft Matter. 2010 Jan 1; 6(18):4466-4470. PMID: 20953281.
        View in: PubMed
      58. David Merryman W, Engler A. Innovations in cell mechanobiology. J Biomech. 2010 Jan 5; 43(1):1. PMID: 19815212.
        View in: PubMed
      59. Reilly GC, Engler A. Intrinsic extracellular matrix properties regulate stem cell differentiation. J Biomech. 2010 Jan 5; 43(1):55-62. PMID: 19800626.
        View in: PubMed
      60. Engler A, Chan M, Boettiger D, Schwarzbauer JE. A novel mode of cell detachment from fibrillar fibronectin matrix under shear. J Cell Sci. 2009 May 15; 122(Pt 10):1647-53. PMID: 19401337.
        View in: PubMed
      61. Engler A, Humbert PO, Wehrle-Haller B, Weaver VM. Multiscale modeling of form and function. Science. 2009 Apr 10; 324(5924):208-12. PMID: 19359578.
        View in: PubMed
      62. Sen S, Engler A, Discher DE. Matrix strains induced by cells: Computing how far cells can feel. Cell Mol Bioeng. 2009 Mar 1; 2(1):39-48. PMID: 20582230.
        View in: PubMed
      63. Oh S, Brammer KS, Li YS, Teng D, Engler A, Chien S, Jin S. Stem cell fate dictated solely by altered nanotube dimension. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2130-5. PMID: 19179282.
        View in: PubMed
      64. Engler A, Carag-Krieger C, Johnson CP, Raab M, Tang HY, Speicher DW, Sanger JW, Sanger JM, Discher DE. Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating. J Cell Sci. 2008 Nov 15; 121(Pt 22):3794-802. PMID: 18957515.
        View in: PubMed
      65. Williams CM, Engler A, Slone RD, Galante LL, Schwarzbauer JE. Fibronectin expression modulates mammary epithelial cell proliferation during acinar differentiation. Cancer Res. 2008 May 1; 68(9):3185-92. PMID: 18451144.
        View in: PubMed
      66. Engler A, Sweeney HL, Discher DE, Schwarzbauer JE. Extracellular matrix elasticity directs stem cell differentiation. J Musculoskelet Neuronal Interact. 2007 Oct-Dec; 7(4):335. PMID: 18094500.
        View in: PubMed
      67. Rehfeldt F, Engler A, Eckhardt A, Ahmed F, Discher DE. Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery. Adv Drug Deliv Rev. 2007 Nov 10; 59(13):1329-39. PMID: 17900747.
        View in: PubMed
      68. Frey MT, Engler A, Discher DE, Lee J, Wang YL. Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy. Methods Cell Biol. 2007; 83:47-65. PMID: 17613304.
        View in: PubMed
      69. Engler A, Rehfeldt F, Sen S, Discher DE. Microtissue elasticity: measurements by atomic force microscopy and its influence on cell differentiation. Methods Cell Biol. 2007; 83:521-45. PMID: 17613323.
        View in: PubMed
      70. Engler A, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell. 2006 Aug 25; 126(4):677-89. PMID: 16923388.
        View in: PubMed
      71. Brown AG, Leite RS, Engler A, Discher DE, Strauss JF. A hemoglobin fragment found in cervicovaginal fluid from women in labor potentiates the action of agents that promote contraction of smooth muscle cells. Peptides. 2006 Jul; 27(7):1794-800. PMID: 16621150.
        View in: PubMed
      72. Berry MF, Engler A, Woo YJ, Pirolli TJ, Bish LT, Jayasankar V, Morine KJ, Gardner TJ, Discher DE, Sweeney HL. Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol. 2006 Jun; 290(6):H2196-203. PMID: 16473959.
        View in: PubMed
      73. Dahl KN, Engler A, Pajerowski JD, Discher DE. Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures. Biophys J. 2005 Oct; 89(4):2855-64. PMID: 16055543.
        View in: PubMed
      74. Engler A, Griffin MA, Sen S, Bönnemann CG, Sweeney HL, Discher DE. Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. J Cell Biol. 2004 Sep 13; 166(6):877-87. PMID: 15364962.
        View in: PubMed
      75. Richert L, Engler A, Discher DE, Picart C. Elasticity of native and cross-linked polyelectrolyte multilayer films. Biomacromolecules. 2004 Sep-Oct; 5(5):1908-16. PMID: 15360305.
        View in: PubMed
      76. Dalhaimer P, Engler A, Parthasarathy R, Discher DE. Targeted worm micelles. Biomacromolecules. 2004 Sep-Oct; 5(5):1714-9. PMID: 15360279.
        View in: PubMed
      77. Griffin MA, Engler A, Barber TA, Healy KE, Sweeney HL, Discher DE. Patterning, prestress, and peeling dynamics of myocytes. Biophys J. 2004 Feb; 86(2):1209-22. PMID: 14747355.
        View in: PubMed
      78. Engler A, Bacakova L, Newman C, Hategan A, Griffin M, Discher D. Substrate compliance versus ligand density in cell on gel responses. Biophys J. 2004 Jan; 86(1 Pt 1):617-28. PMID: 14695306.
        View in: PubMed
      Adam's Networks
      Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Similar People
      People who share similar concepts with this person.
      _
      Same Department
      Physical Neighbors
      People whose addresses are nearby this person.
      _