Ester Kwon

Title(s)	Associate Professor, Bioengineering
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

education and training

UC Berkeley, Berkeley	B.S.	2004	Bioengineering
UC Berkeley, Berkeley	B.A.	2004	Molecular & Cell Biology
University of Washington, Seattle	Ph.D.	2010	Bioengineering
Massachusetts Institute of Technology, Cambridge	Postdoc

Research

research activities and funding

Nanoscale biomaterials for targeted repair in traumatic brain injury
NIH DP2NS111507Sep 30, 2018 - May 31, 2023
Role: Principal Investigator

Peptide-mediated delivery of siRNA for treatment of ovarian cancer
NIH F32CA177094Feb 1, 2014 - Jan 31, 2017
Role: Principal Investigator

Dvelopment of multi-component peptide vehicles for in vivo neuronal gene therapy
NIH F31NS064805Feb 23, 2009 - Feb 22, 2011
Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

PEGylated Multimeric RNA Nanoparticles for siRNA Delivery in Traumatic Brain Injury. Small. 2025 03; 21(10):e2405806. Han S, Yoo W, Carton O, Joo J, Kwon EJ. PMID: 39498752; PMCID: PMC11899522.

View in: PubMed Mentions: 1 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Animals
Spatial Measurement and Inhibition of Calpain Activity in Traumatic Brain Injury with an Activity-Based Nanotheranostic Platform. ACS Nano. 2024 09 17; 18(37):25565-25576. Madias MI, Stessman LN, Warlof SJ, Kudryashev JA, Kwon EJ. PMID: 39236689; PMCID: PMC11411711.

View in: PubMed Mentions: Fields:
Nan Nanotechnology
Translation:Humans Animals
Author Correction: Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion. Nat Biotechnol. 2024 Sep; 42(9):1467. Schmok JC, Jain M, Street LA, Tankka AT, Schafer D, Her HL, Elmsaouri S, Gosztyla ML, Boyle EA, Jagannatha P, Luo EC, Kwon EJ, Jovanovic M, Yeo GW. PMID: 38418649; PMCID: PMC11392803.

View in: PubMed Mentions: Fields:
Bio Biotechnology
Robust genome and cell engineering via in vitro and in situ circularized RNAs. Nat Biomed Eng. 2025 Jan; 9(1):109-126. Tong M, Palmer N, Dailamy A, Kumar A, Khaliq H, Han S, Finburgh E, Wing M, Hong C, Xiang Y, Miyasaki K, Portell A, Rainaldi J, Suhardjo A, Nourreddine S, Chew WL, Kwon EJ, Mali P. PMID: 39187662.

View in: PubMed Mentions: Fields:
Bio Biomedical Engineering
Translation:Humans Animals Cells
Mechanobiological Modulation of In Vitro Astrocyte Reactivity Using Variable Gel Stiffness. ACS Biomater Sci Eng. 2024 Jul 08; 10(7):4279-4296. C Benincasa J, Madias MI, Kandell RM, Delgado-Garcia LM, Engler AJ, Kwon EJ, Porcionatto MA. PMID: 38870483; PMCID: PMC11234334.

View in: PubMed Mentions: 1 Fields:
Bio Biomedical Engineering Bio Biotechnology
Translation:Animals Cells
Reprograming Clots for In Vivo Chemical Targeting in Traumatic Brain Injury. Adv Mater. 2024 Aug; 36(31):e2301738. Kandell RM, Wu JR, Kwon EJ. PMID: 38780012; PMCID: PMC11293973.

View in: PubMed Mentions: 1 Fields:
Bio Biophysics Che Chemistry
Translation:Animals
Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion. Nat Biotechnol. 2024 Sep; 42(9):1429-1441. Schmok JC, Jain M, Street LA, Tankka AT, Schafer D, Her HL, Elmsaouri S, Gosztyla ML, Boyle EA, Jagannatha P, Luo EC, Kwon EJ, Jovanovic M, Yeo GW. PMID: 38168984; PMCID: PMC11389820.

View in: PubMed Mentions: 4 Fields:
Bio Biotechnology
Translation:Humans Cells
Infusible Extracellular Matrix Biomaterial Promotes Vascular Integrity and Modulates the Inflammatory Response in Acute Traumatic Brain Injury. Adv Healthc Mater. 2023 10; 12(25):e2300782. Diaz MD, Kandell RM, Wu JR, Chen A, Christman KL, Kwon EJ. PMID: 37390094; PMCID: PMC10592293.

View in: PubMed Mentions: 2 Fields:
Bio Biomedical Engineering Tec Technology
Translation:Humans Animals Cells
Analysis of PEG-lipid anchor length on lipid nanoparticle pharmacokinetics and activity in a mouse model of traumatic brain injury. Biomater Sci. 2023 Jun 13; 11(12):4238-4253. Waggoner LE, Miyasaki KF, Kwon EJ. PMID: 36987922; PMCID: PMC10262813.

View in: PubMed Mentions: 16 Fields:
Bio Biomedical Engineering The Therapeutics
Translation:Animals
An Activity-Based Nanosensor for Minimally-Invasive Measurement of Protease Activity in Traumatic Brain Injury. Adv Funct Mater. 2023 Jul 11; 33(28). Kudryashev JA, Madias MI, Kandell RM, Lin QX, Kwon EJ. PMID: 37873031; PMCID: PMC10586543.

View in: PubMed Mentions: 4
Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain. Adv Drug Deliv Rev. 2023 06; 197:114820. Wu JR, Hernandez Y, Miyasaki KF, Kwon EJ. PMID: 37054953.

View in: PubMed Mentions: 17 Fields:
Dru Drug Therapy Pha Pharmacology
Translation:Humans
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues. Nat Biomed Eng. 2023 02; 7(2):94-109. Spang MT, Middleton R, Diaz M, Hunter J, Mesfin J, Banka A, Sullivan H, Wang R, Lazerson TS, Bhatia S, Corbitt J, D'Elia G, Sandoval-Gomez G, Kandell R, Vratsanos MA, Gnanasekaran K, Kato T, Igata S, Luo C, Osborn KG, Gianneschi NC, Eniola-Adefeso O, Cabrales P, Kwon EJ, Contijoch F, Reeves RR, DeMaria AN, Christman KL. PMID: 36581694; PMCID: PMC10166066.

View in: PubMed Mentions: 14 Fields:
Bio Biomedical Engineering
Translation:Animals Cells
Heads Up! Interlinked Amyloidogenic and Axonal Transport Pathways in Concussion-Induced Neurodegeneration. Neurosci Insights. 2022; 17:26331055221129641. Almenar-Queralt A, Dos Santos Chaves R, Kwon EJ, Shah SB. PMID: 36274925; PMCID: PMC9580075.

View in: PubMed Mentions: 2
Porous Silicon Nanoparticles Targeted to the Extracellular Matrix for Therapeutic Protein Delivery in Traumatic Brain Injury. Bioconjug Chem. 2022 09 21; 33(9):1685-1697. Waggoner LE, Kang J, Zuidema JM, Vijayakumar S, Hurtado AA, Sailor MJ, Kwon EJ. PMID: 36017941; PMCID: PMC9492643.

View in: PubMed Mentions: 7 Fields:
Bio Biochemistry
Translation:Animals Cells
Targeting the Extracellular Matrix in Traumatic Brain Injury Increases Signal Generation from an Activity-Based Nanosensor. ACS Nano. 2021 12 28; 15(12):20504-20516. Kandell RM, Kudryashev JA, Kwon EJ. PMID: 34870408; PMCID: PMC8716428.

View in: PubMed Mentions: 8 Fields:
Nan Nanotechnology
Translation:Humans Cells
Pharmacokinetic Analysis of Peptide-Modified Nanoparticles with Engineered Physicochemical Properties in a Mouse Model of Traumatic Brain Injury. AAPS J. 2021 08 16; 23(5):100. Waggoner LE, Madias MI, Hurtado AA, Kwon EJ. PMID: 34401968; PMCID: PMC8367032.

View in: PubMed Mentions: 8 Fields:
Dru Drug Therapy Pha Pharmacology
Translation:Humans Animals
Selective Permeabilization of Gram-Negative Bacterial Membranes Using Multivalent Peptide Constructs for Antibiotic Sensitization. ACS Infect Dis. 2021 04 09; 7(4):721-732. Chan LW, Hern KE, Ngambenjawong C, Lee K, Kwon EJ, Hung DT, Bhatia SN. PMID: 33689277; PMCID: PMC8043124.

View in: PubMed Mentions: 9 Fields:
Ant Anti-Infective Agents Dru Drug Therapy Mic Microbiology
Translation:Cells
Peptide Spiders: Peptide-Polymer Conjugates to Traffic Nucleic Acids. Mol Pharm. 2020 09 08; 17(9):3633-3642. Kwon EJ, Ko H, Bhatia SN. PMID: 32786959; PMCID: PMC7986012.

View in: PubMed Mentions: 3 Fields:
Mol Molecular Biology Pha Pharmacology
Nanomedicine for Acute Brain Injuries: Insight from Decades of Cancer Nanomedicine. Mol Pharm. 2021 02 01; 18(2):522-538. Kandell RM, Waggoner LE, Kwon EJ. PMID: 32584042; PMCID: PMC7759589.

View in: PubMed Mentions: 8 Fields:
Mol Molecular Biology Pha Pharmacology
Translation:Humans Animals
An Activity-Based Nanosensor for Traumatic Brain Injury. ACS Sens. 2020 03 27; 5(3):686-692. Kudryashev JA, Waggoner LE, Leng HT, Mininni NH, Kwon EJ. PMID: 32100994; PMCID: PMC7534893.

View in: PubMed Mentions: 12 Fields:
Bio Biotechnology Che Chemistry Techniques
Translation:Animals
Tumor-Targeting, MicroRNA-Silencing Porous Silicon Nanoparticles for Ovarian Cancer Therapy. ACS Appl Mater Interfaces. 2019 Jul 10; 11(27):23926-23937. Bertucci A, Kim KH, Kang J, Zuidema JM, Lee SH, Kwon EJ, Kim D, Howell SB, Ricci F, Ruoslahti E, Jang HJ, Sailor MJ. PMID: 31251556.

View in: PubMed Mentions: 33 Fields:
Bio Biomedical Engineering Bio Biotechnology
Translation:Humans Animals Cells
iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer. Mol Cancer Ther. 2018 11; 17(11):2377-2388. Lo JH, Hao L, Muzumdar MD, Raghavan S, Kwon EJ, Pulver EM, Hsu F, Aguirre AJ, Wolpin BM, Fuchs CS, Hahn WC, Jacks T, Bhatia SN. PMID: 30097486; PMCID: PMC6298224.

View in: PubMed Mentions: 33 Fields:
Ant Antineoplastic Agents
Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections. Adv Mater. 2017 Sep; 29(35). Kwon EJ, Skalak M, Bertucci A, Braun G, Ricci F, Ruoslahti E, Sailor MJ, Bhatia SN. PMID: 28699173; PMCID: PMC5765747.

View in: PubMed Mentions: 31 Fields:
Bio Biophysics Che Chemistry
Ultrasensitive tumour-penetrating nanosensors of protease activity. Nat Biomed Eng. 2017; 1. Kwon EJ, Dudani JS, Bhatia SN. PMID: 28970963; PMCID: PMC5621765.

View in: PubMed Mentions: 34 Fields:
Bio Biomedical Engineering
Comparison of Modular PEG Incorporation Strategies for Stabilization of Peptide-siRNA Nanocomplexes. Bioconjug Chem. 2016 10 19; 27(10):2323-2331. Lo JH, Kwon EJ, Zhang AQ, Singhal P, Bhatia SN. PMID: 27583545; PMCID: PMC5410868.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry
Addendum: The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nat Neurosci. 2016 07 26; 19(8):1115. Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH. PMID: 27459408.

View in: PubMed Mentions: 1 Fields:
Neu Neurology
Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries. ACS Nano. 2016 08 23; 10(8):7926-33. Kwon EJ, Skalak M, Lo Bu R, Bhatia SN. PMID: 27429164; PMCID: PMC5896006.

View in: PubMed Mentions: 56 Fields:
Nan Nanotechnology
Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain. Adv Mater. 2016 Sep; 28(36):7962-7969. Kang J, Joo J, Kwon EJ, Skalak M, Hussain S, She ZG, Ruoslahti E, Bhatia SN, Sailor MJ. PMID: 27383373; PMCID: PMC6274592.

View in: PubMed Mentions: 44 Fields:
Bio Biophysics Che Chemistry
A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries. Nat Commun. 2016 06 28; 7:11980. Mann AP, Scodeller P, Hussain S, Joo J, Kwon E, Braun GB, Mölder T, She ZG, Kotamraju VR, Ranscht B, Krajewski S, Teesalu T, Bhatia S, Sailor MJ, Ruoslahti E. PMID: 27351915; PMCID: PMC4931241.

View in: PubMed Mentions: 80 Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
Porous silicon-graphene oxide core-shell nanoparticles for targeted delivery of siRNA to the injured brain. Nanoscale Horiz. 2016 Sep 01; 1(5):407-414. Joo J, Kwon EJ, Kang J, Skalak M, Anglin EJ, Mann AP, Ruoslahti E, Bhatia SN, Sailor MJ. PMID: 29732165; PMCID: PMC5935492.

View in: PubMed Mentions: 23
Smart nanosystems: Bio-inspired technologies that interact with the host environment. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14460-6. Kwon EJ, Lo JH, Bhatia SN. PMID: 26598694; PMCID: PMC4664363.

View in: PubMed Mentions: 16 Fields:
Sci Science
Translation:Humans Cells
The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nat Neurosci. 2015 Jul; 18(7):1008-16. Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH. PMID: 26005852; PMCID: PMC4506960.

View in: PubMed Mentions: 114 Fields:
Neu Neurology
Translation:Humans Animals Cells
Drug-induced amplification of nanoparticle targeting to tumors. Nano Today. 2014 Oct; 9(5):550-559. Lin KY, Kwon EJ, Lo JH, Bhatia SN. PMID: 29731806; PMCID: PMC5935498.

View in: PubMed Mentions: 9
MicroRNAs in learning, memory, and neurological diseases. Learn Mem. 2012 Aug 16; 19(9):359-68. Wang W, Kwon EJ, Tsai LH. PMID: 22904366.

View in: PubMed Mentions: 101 Fields:
Neu Neurology
Translation:Humans
A truncated HGP peptide sequence that retains endosomolytic activity and improves gene delivery efficiencies. Mol Pharm. 2010 Aug 02; 7(4):1260-5. Kwon EJ, Liong S, Pun SH. PMID: 20476763; PMCID: PMC3018701.

View in: PubMed Mentions: 13 Fields:
Mol Molecular Biology Pha Pharmacology
Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone. Biomaterials. 2010 Mar; 31(8):2417-24. Kwon EJ, Lasiene J, Jacobson BE, Park IK, Horner PJ, Pun SH. PMID: 20004466; PMCID: PMC2813955.

View in: PubMed Mentions: 25 Fields:
Bio Biomedical Engineering
Application of an HIV gp41-derived peptide for enhanced intracellular trafficking of synthetic gene and siRNA delivery vehicles. Bioconjug Chem. 2008 Apr; 19(4):920-7. Kwon EJ, Bergen JM, Pun SH. PMID: 18376855.

View in: PubMed Mentions: 27 Fields:
Bio Biochemistry
Translation:Humans Cells
Application of an environmentally sensitive fluorophore for rapid analysis of the binding and internalization efficiency of gene carriers. Bioconjug Chem. 2008 Jan; 19(1):377-84. Bergen JM, Kwon EJ, Shen TW, Pun SH. PMID: 18062659; PMCID: PMC2547138.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry