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A probabilistic algorithm for optimising the steady-state diffusional flux into a partially absorbing body. Sci Rep. 2023 Dec 20; 13(1):22815.
Nicolaou K, Mulder BM. PMID: 38129494; PMCID: PMC10739912.
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PubMed Mentions: Fields:
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A unified strategy for the total syntheses of eribulin and a macrolactam analogue of halichondrin B. Proc Natl Acad Sci U S A. 2022 08 09; 119(32):e2208938119.
Nicolaou KC, Pan S, Shelke Y, Rigol S, Bao R, Das D, Ye Q. PMID: 35930662; PMCID: PMC9371655.
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PubMed Mentions:
2 Fields:
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Total Synthesis of Gukulenin B via Sequential Tropolone Functionalizations. J Am Chem Soc. 2022 03 23; 144(11):5190-5196.
Nicolaou KC, Yu R, Lu Z, Alvarez FG. PMID: 35275627.
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PubMed Mentions:
2 Fields:
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A Highly Convergent Total Synthesis of Norhalichondrin B. J Am Chem Soc. 2021 12 15; 143(49):20970-20979.
Nicolaou KC, Pan S, Shelke Y, Ye Q, Das D, Rigol S. PMID: 34851106.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Corrigendum: The Role of Organic Synthesis in the Emergence and Development of Antibody-Drug Conjugates as Targeted Cancer Therapies. Angew Chem Int Ed Engl. 2021 Aug 02; 60(32):17246-17247.
Nicolaou KC, Rigol S. PMID: 34312957.
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PubMed Mentions: Fields:
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Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect. Proc Natl Acad Sci U S A. 2021 06 22; 118(25).
Nicolaou KC, Rigol S, Pitsinos EN, Das D, Lu Y, Rout S, Schammel AW, Holte D, Lin B, Gu C, Sarvaiya H, Trinidad J, Barbour N, Valdiosera AM, Sandoval J, Lee C, Aujay M, Fernando H, Dhar A, Karsunky H, Taylor N, Pysz M, Gavrilyuk J. PMID: 34155147; PMCID: PMC8237573.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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A Reverse Approach to the Total Synthesis of Halichondrin B. J Am Chem Soc. 2021 06 23; 143(24):9267-9276.
Nicolaou KC, Pan S, Shelke Y, Das D, Ye Q, Lu Y, Sau S, Bao R, Rigol S. PMID: 34105959.
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PubMed Mentions:
5 Fields:
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Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis. J Org Chem. 2021 02 19; 86(4):3377-3421.
Nicolaou KC, Pan S, Pulukuri KK, Ye Q, Rigol S, Erande RD, Vourloumis D, Nocek BP, Munneke S, Lyssikatos J, Valdiosera A, Gu C, Lin B, Sarvaiaya H, Trinidad J, Sandoval J, Lee C, Hammond M, Aujay M, Taylor N, Pysz M, Purcell JW, Gavrilyuk J. PMID: 33544599.
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PubMed Mentions:
3 Fields:
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Design, Synthesis, and Biological Investigation of Thailanstatin A and Spliceostatin D Analogues Containing Tetrahydropyran, Tetrahydrooxazine, and Fluorinated Structural Motifs. J Org Chem. 2021 02 05; 86(3):2499-2521.
Nicolaou KC, Rekula SR, Kumar SM, Podilapu AR, Matuszak RP, Jung PM, Lam LT, Phillips AC, Lyssikatos J, Munneke S, Gu C, Sarvaiya H, Sandoval J, Hammond M, Aujay M, Purcell JW, Reilly RM, Gavrilyuk J. PMID: 33417458.
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PubMed Mentions:
2 Fields:
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Total Synthesis of the Monomeric Unit of Lomaiviticin A. J Am Chem Soc. 2020 11 25; 142(47):20201-20207.
Nicolaou KC, Chen Q, Li R, Anami Y, Tsuchikama K. PMID: 33186022.
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PubMed Mentions:
7 Fields:
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Streamlined Symmetrical Total Synthesis of Disorazole B1 and Design, Synthesis, and Biological Investigation of Disorazole Analogues. J Am Chem Soc. 2020 09 09; 142(36):15476-15487.
Nicolaou KC, Krieger J, Murhade GM, Subramanian P, Dherange BD, Vourloumis D, Munneke S, Lin B, Gu C, Sarvaiaya H, Sandoval J, Zhang Z, Aujay M, Purcell JW, Gavrilyuk J. PMID: 32852944.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Synthesis and Biological Evaluation of Shishijimicin A-Type Linker-Drugs and Antibody-Drug Conjugates. J Am Chem Soc. 2020 07 22; 142(29):12890-12899.
Nicolaou KC, Li R, Chen Q, Lu Z, Pitsinos EN, Schammel A, Lin B, Gu C, Sarvaiya H, Tchelepi R, Valdiosera A, Clubb J, Barbour N, Sisodiya V, Sandoval J, Lee C, Aujay M, Gavrilyuk J. PMID: 32662641.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine. Nat Prod Rep. 2020 11 01; 37(11):1404-1435.
Nicolaou KC, Rigol S. PMID: 32319494; PMCID: PMC7578074.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Design, Synthesis, and Biological Investigation of Epothilone B Analogues Featuring Lactone, Lactam, and Carbocyclic Macrocycles, Epoxide, Aziridine, and 1,1-Difluorocyclopropane and Other Fluorine Residues. J Org Chem. 2020 03 06; 85(5):2865-2917.
Nicolaou KC, Shelke YG, Dherange BD, Kempema A, Lin B, Gu C, Sandoval J, Hammond M, Aujay M, Gavrilyuk J. PMID: 32065746.
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PubMed Mentions:
4 Fields:
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Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics. J Am Chem Soc. 2020 02 05; 142(5):2549-2561.
Nicolaou KC, Das D, Lu Y, Rout S, Pitsinos EN, Lyssikatos J, Schammel A, Sandoval J, Hammond M, Aujay M, Gavrilyuk J. PMID: 31976660.
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PubMed Mentions:
15 Fields:
Translation:
Humans
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The Role of Organic Synthesis in the Emergence and Development of Antibody-Drug Conjugates as Targeted Cancer Therapies. Angew Chem Int Ed Engl. 2019 08 12; 58(33):11206-11241.
Nicolaou KC, Rigol S. PMID: 31012193.
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PubMed Mentions:
28 Fields:
Translation:
Humans
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DNA Binding and Cleavage Modes of Shishijimicin A. J Am Chem Soc. 2019 05 15; 141(19):7842-7852.
Zhang H, Li R, Ba S, Lu Z, Pitsinos EN, Li T, Nicolaou KC. PMID: 31050893.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Correction to "Short Total Synthesis of Δ12-Prostaglandin J2 and Related Prostaglandins. Design, Synthesis, and Biological Evaluation of Macrocyclic Δ12-Prostaglandin J2 Analogues". J Org Chem. 2019 Feb 15; 84(4):2377-2378.
Nicolaou KC, Pulukuri KK, Rigol S, Peitsinis Z, Yu R, Kishigami S, Cen N, Aujay M, Sandoval J, Zepeda N, Gavrilyuk J. PMID: 30715889.
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PubMed Mentions:
1 Fields:
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Total Synthesis in Search of Potent Antibody-Drug Conjugate Payloads. From the Fundamentals to the Translational. Acc Chem Res. 2019 01 15; 52(1):127-139.
Nicolaou KC, Rigol S. PMID: 30575399.
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PubMed Mentions:
12 Fields:
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Short Total Synthesis of Δ12-Prostaglandin J2 and Related Prostaglandins. Design, Synthesis, and Biological Evaluation of Macrocyclic Δ12-Prostaglandin J2 Analogues. J Org Chem. 2019 01 04; 84(1):365-378.
Nicolaou KC, Pulukuri KK, Rigol S, Peitsinis Z, Yu R, Kishigami S, Cen N, Aujay M, Sandoval J, Zepeda N, Gavrilyuk J. PMID: 30557504.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Streamlined Total Synthesis of Shishijimicin A and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues thereof and Practical Syntheses of PhthNSSMe and Related Sulfenylating Reagents. J Am Chem Soc. 2018 09 26; 140(38):12120-12136.
Nicolaou KC, Li R, Lu Z, Pitsinos EN, Alemany LB, Aujay M, Lee C, Sandoval J, Gavrilyuk J. PMID: 30216054.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Total Syntheses of Thailanstatins A-C, Spliceostatin D, and Analogues Thereof. Stereodivergent Synthesis of Tetrasubstituted Dihydro- and Tetrahydropyrans and Design, Synthesis, Biological Evaluation, and Discovery of Potent Antitumor Agents. J Am Chem Soc. 2018 07 05; 140(26):8303-8320.
Nicolaou KC, Rhoades D, Kumar SM. PMID: 29943984.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Total Synthesis and Full Structural Assignment of Namenamicin. J Am Chem Soc. 2018 07 05; 140(26):8091-8095.
Nicolaou KC, Li R, Lu Z, Pitsinos EN, Alemany LB. PMID: 29932325.
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PubMed Mentions:
3 Fields:
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Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates. J Am Chem Soc. 2018 03 14; 140(10):3690-3711.
Nicolaou KC, Erande RD, Yin J, Vourloumis D, Aujay M, Sandoval J, Munneke S, Gavrilyuk J. PMID: 29381062.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Total Syntheses of Disorazoles A₁ and B₁ and Full Structural Elucidation of Disorazole B₁. J Am Chem Soc. 2017 11 08; 139(44):15636-15639.
Nicolaou KC, Bellavance G, Buchman M, Pulukuri KK. PMID: 29064682.
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PubMed Mentions:
6 Fields:
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Enantioselective Total Synthesis of Antibiotic CJ-16,264, Synthesis and Biological Evaluation of Designed Analogues, and Discovery of Highly Potent and Simpler Antibacterial Agents. J Am Chem Soc. 2017 11 08; 139(44):15868-15877.
Nicolaou KC, Pulukuri KK, Rigol S, Buchman M, Shah AA, Cen N, McCurry MD, Beabout K, Shamoo Y. PMID: 29064688; PMCID: PMC5826612.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues. J Am Chem Soc. 2017 11 01; 139(43):15467-15478.
Nicolaou KC, Chen P, Zhu S, Cai Q, Erande RD, Li R, Sun H, Pulukuri KK, Rigol S, Aujay M, Sandoval J, Gavrilyuk J. PMID: 29052423.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Experimental Evolution of Diverse Strains as a Method for the Determination of Biochemical Mechanisms of Action for Novel Pyrrolizidinone Antibiotics. ACS Infect Dis. 2017 11 10; 3(11):854-865.
Beabout K, McCurry MD, Mehta H, Shah AA, Pulukuri KK, Rigol S, Wang Y, Nicolaou KC, Shamoo Y. PMID: 28942642; PMCID: PMC5817888.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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A brief history of antibiotics and select advances in their synthesis. J Antibiot (Tokyo). 2018 02; 71(2):153-184.
Nicolaou KC, Rigol S. PMID: 28676714.
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PubMed Mentions:
53 Fields:
Translation:
Humans
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12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents. J Am Chem Soc. 2017 05 31; 139(21):7318-7334.
Nicolaou KC, Rhoades D, Wang Y, Bai R, Hamel E, Aujay M, Sandoval J, Gavrilyuk J. PMID: 28513142.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Asymmetric Alkylation of Anthrones, Enantioselective Total Synthesis of (-)- and (+)-Viridicatumtoxins B and Analogues Thereof: Absolute Configuration and Potent Antibacterial Agents. J Am Chem Soc. 2017 03 15; 139(10):3736-3746.
Nicolaou KC, Liu G, Beabout K, McCurry MD, Shamoo Y. PMID: 28256128; PMCID: PMC5826551.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Streamlined Total Synthesis of Uncialamycin and Its Application to the Synthesis of Designed Analogues for Biological Investigations. J Am Chem Soc. 2016 07 06; 138(26):8235-46.
Nicolaou KC, Wang Y, Lu M, Mandal D, Pattanayak MR, Yu R, Shah AA, Chen JS, Zhang H, Crawford JJ, Pasunoori L, Poudel YB, Chowdari NS, Pan C, Nazeer A, Gangwar S, Vite G, Pitsinos EN. PMID: 27266267.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Total Synthesis of Thailanstatin A. J Am Chem Soc. 2016 06 22; 138(24):7532-5.
Nicolaou KC, Rhoades D, Lamani M, Pattanayak MR, Kumar SM. PMID: 27266914.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Total Synthesis of Δ(12) -Prostaglandin J3 : Evolution of Synthetic Strategies to a Streamlined Process. Chemistry. 2016 06 13; 22(25):8559-70.
Nicolaou KC, Pulukuri KK, Yu R, Rigol S, Heretsch P, Grove CI, Hale CR, ElMarrouni A. PMID: 27187634.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Synthesis and Biological Investigation of Δ(12)-Prostaglandin J3 (Δ(12)-PGJ3) Analogues and Related Compounds. J Am Chem Soc. 2016 05 25; 138(20):6550-60.
Nicolaou KC, Pulukuri KK, Rigol S, Heretsch P, Yu R, Grove CI, Hale CR, ElMarrouni A, Fetz V, Brönstrup M, Aujay M, Sandoval J, Gavrilyuk J. PMID: 27171618.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Efficient Synthesis of Dimeric Oxazoles, Piperidines and Tetrahydroisoquinolines from N-Substituted 2-Oxazolones. Chemistry. 2016 06 01; 22(23):7696-701.
He Y, Agarwal PK, Kiran IN, Yu R, Cao B, Zou C, Zhou X, Xu H, Xu B, Zhu L, Lan Y, Nicolaou KC. PMID: 27113382.
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PubMed Mentions: Fields:
Translation:
Cells
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Total Synthesis of Trioxacarcins DC-45-A1, A, D, C, and C7″-epi-C and Full Structural Assignment of Trioxacarcin C. J Am Chem Soc. 2016 Mar 09; 138(9):3118-24.
Nicolaou KC, Cai Q, Sun H, Qin B, Zhu S. PMID: 26910506.
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PubMed Mentions:
8 Fields:
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Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins. J Am Chem Soc. 2016 Feb 10; 138(5):1698-708.
Nicolaou KC, Yin J, Mandal D, Erande RD, Klahn P, Jin M, Aujay M, Sandoval J, Gavrilyuk J, Vourloumis D. PMID: 26829208.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs. ChemMedChem. 2016 Jan 05; 11(1):31-7.
Nicolaou KC, Vourloumis D, Totokotsopoulos S, Papakyriakou A, Karsunky H, Fernando H, Gavrilyuk J, Webb D, Stepan AF. PMID: 26585829.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues. ChemMedChem. 2015 Dec; 10(12):1974-9.
Nicolaou KC, Rhoades D, Wang Y, Totokotsopoulos S, Bai R, Hamel E. PMID: 26447977.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Practical Synthesis of p- and o-Amino- and Methoxyphenolic Anthraquinones. Angew Chem Int Ed Engl. 2015 Oct 19; 54(43):12687-91.
Nicolaou KC, Lu M, Chen P, Shah AA. PMID: 26332286.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Total Synthesis of Shishijimicin A. J Am Chem Soc. 2015 Jul 15; 137(27):8716-9.
Nicolaou KC, Lu Z, Li R, Woods JR, Sohn TI. PMID: 26133230.
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PubMed Mentions:
6 Fields:
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Total Synthesis and Structural Revision of Antibiotic CJ-16,264. Angew Chem Int Ed Engl. 2015 Aug 03; 54(32):9203-8.
Nicolaou KC, Shah AA, Korman H, Khan T, Shi L, Worawalai W, Theodorakis EA. PMID: 26096055; PMCID: PMC4530996.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Synthesis and biological evaluation of dimeric furanoid macroheterocycles: discovery of new anticancer agents. J Am Chem Soc. 2015 Apr 15; 137(14):4766-70.
Nicolaou KC, Nilewski C, Hale CR, Ahles CF, Chiu CA, Ebner C, ElMarrouni A, Yang L, Stiles K, Nagrath D. PMID: 25827338.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Total synthesis of trioxacarcin DC-45-A2. Angew Chem Int Ed Engl. 2015 Mar 02; 54(10):3074-8.
Nicolaou KC, Cai Q, Qin B, Petersen MT, Mikkelsen RJ, Heretsch P. PMID: 25583408.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Synthesis and biological evaluation of QRSTUVWXYZA' domains of maitotoxin. J Am Chem Soc. 2014 Nov 19; 136(46):16444-51.
Nicolaou KC, Heretsch P, Nakamura T, Rudo A, Murata M, Konoki K. PMID: 25374117; PMCID: PMC4244842.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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In vitro chronic effects on hERG channel caused by the marine biotoxin azaspiracid-2. Toxicon. 2014 Dec; 91:69-75.
Ferreiro SF, Vilariño N, Louzao MC, Nicolaou KC, Frederick MO, Botana LM. PMID: 25286396; PMCID: PMC4252744.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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The chemistry-biology-medicine continuum and the drug discovery and development process in academia. Chem Biol. 2014 Sep 18; 21(9):1039-45.
Nicolaou KC. PMID: 25237851.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Total synthesis of myceliothermophins C, D, and E. Angew Chem Int Ed Engl. 2014 Oct 06; 53(41):10970-4.
Nicolaou KC, Shi L, Lu M, Pattanayak MR, Shah AA, Ioannidou HA, Lamani M. PMID: 25163463; PMCID: PMC4257465.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Total synthesis of viridicatumtoxin B and analogues thereof: strategy evolution, structural revision, and biological evaluation. J Am Chem Soc. 2014 Aug 27; 136(34):12137-60.
Nicolaou KC, Hale CR, Nilewski C, Ioannidou HA, ElMarrouni A, Nilewski LG, Beabout K, Wang TT, Shamoo Y. PMID: 25317739; PMCID: PMC4210137.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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Total synthesis of Δ¹²-prostaglandin J₃, a highly potent and selective antileukemic agent. Angew Chem Int Ed Engl. 2014 Sep 22; 53(39):10443-7.
Nicolaou KC, Heretsch P, ElMarrouni A, Hale CR, Pulukuri KK, Kudva AK, Narayan V, Prabhu KS. PMID: 25098181; PMCID: PMC4169176.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Advancing the drug discovery and development process. Angew Chem Int Ed Engl. 2014 Aug 25; 53(35):9128-40.
Nicolaou KC. PMID: 25045053.
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PubMed Mentions:
22 Fields:
Translation:
Humans
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Academic-industrial partnerships in drug discovery and development. Angew Chem Int Ed Engl. 2014 May 05; 53(19):4730-1.
Nicolaou KC. PMID: 24706618.
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PubMed Mentions:
2 Fields:
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Organic synthesis: the art and science of replicating the molecules of living nature and creating others like them in the laboratory. Proc Math Phys Eng Sci. 2014 Mar 08; 470(2163):20130690.
Nicolaou KC. PMID: 24611027; PMCID: PMC3899854.
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PubMed Mentions:
25
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Cyclic marinopyrrole derivatives as disruptors of Mcl-1 and Bcl-x(L) binding to Bim. Mar Drugs. 2014 Mar 07; 12(3):1335-48.
Cheng C, Liu Y, Balasis ME, Simmons NL, Li J, Song H, Pan L, Qin Y, Nicolaou KC, Sebti SM, Li R. PMID: 24608970; PMCID: PMC3967213.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Microsphere-based immunoassay for the detection of azaspiracids. Anal Biochem. 2014 Feb 15; 447:58-63.
Rodríguez LP, Vilariño N, Louzao MC, Dickerson TJ, Nicolaou KC, Frederick MO, Botana LM. PMID: 24215909; PMCID: PMC3947218.
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PubMed Mentions:
4 Fields:
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In vivo arrhythmogenicity of the marine biotoxin azaspiracid-2 in rats. Arch Toxicol. 2014 Feb; 88(2):425-34.
Ferreiro SF, Vilariño N, Carrera C, Louzao MC, Santamarina G, Cantalapiedra AG, Rodríguez LP, Cifuentes JM, Vieira AC, Nicolaou KC, Frederick MO, Botana LM. PMID: 23934164; PMCID: PMC3946725.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorg Med Chem Lett. 2013 Oct 01; 23(19):5325-8.
Mishra OP, Simmons N, Tyagi S, Pietrofesa R, Shuvaev VV, Valiulin RA, Heretsch P, Nicolaou KC, Christofidou-Solomidou M. PMID: 23978651; PMCID: PMC3809892.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Total synthesis and structural revision of viridicatumtoxin B. Angew Chem Int Ed Engl. 2013 Aug 12; 52(33):8736-41.
Nicolaou KC, Nilewski C, Hale CR, Ioannidou HA, ElMarrouni A, Koch LG. PMID: 23893651; PMCID: PMC3835450.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents. Org Biomol Chem. 2013 Jul 07; 11(25):4154-63.
Nicolaou KC, Valiulin RA. PMID: 23685867; PMCID: PMC3712363.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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The emergence of the structure of the molecule and the art of its synthesis. Angew Chem Int Ed Engl. 2013 Jan 02; 52(1):131-46.
Nicolaou KC. PMID: 23203813.
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PubMed Mentions:
6 Fields:
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How thiostrepton was made in the laboratory. Angew Chem Int Ed Engl. 2012 Dec 07; 51(50):12414-36.
Nicolaou KC. PMID: 23208736; PMCID: PMC3515631.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematocin and discovery of new antiviral and antimalarial agents. J Am Chem Soc. 2012 Oct 17; 134(41):17320-32.
Nicolaou KC, Lu M, Totokotsopoulos S, Heretsch P, Giguère D, Sun YP, Sarlah D, Nguyen TH, Wolf IC, Smee DF, Day CW, Bopp S, Winzeler EA. PMID: 22978674; PMCID: PMC3490634.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP. Clin Cancer Res. 2012 Dec 15; 18(24):6623-33.
Yin S, Kaluz S, Devi NS, Jabbar AA, de Noronha RG, Mun J, Zhang Z, Boreddy PR, Wang W, Wang Z, Abbruscato T, Chen Z, Olson JJ, Zhang R, Goodman MM, Nicolaou KC, Van Meir EG. PMID: 22923450; PMCID: PMC3518680.
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PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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Total syntheses of anominine and tubingensin A. J Am Chem Soc. 2012 May 16; 134(19):8078-81.
Bian M, Wang Z, Xiong X, Sun Y, Matera C, Nicolaou KC, Li A. PMID: 22537293.
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PubMed Mentions:
18 Fields:
Translation:
Cells
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Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application. Pharmacol Rev. 2012 Jul; 64(3):520-39.
Koppaka V, Thompson DC, Chen Y, Ellermann M, Nicolaou KC, Juvonen RO, Petersen D, Deitrich RA, Hurley TD, Vasiliou V. PMID: 22544865; PMCID: PMC3400832.
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PubMed Mentions:
247 Fields:
Translation:
HumansAnimalsCells
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Bio-inspired synthesis and biological evaluation of a colchicine-related compound library. Bioorg Med Chem Lett. 2012 Jun 01; 22(11):3776-80.
Nicolaou KC, Valiulin RA, Pokorski JK, Chang V, Chen JS. PMID: 22542017; PMCID: PMC3353021.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Synthesis of macroheterocycles through intramolecular oxidative coupling of furanoid β-ketoesters. Angew Chem Int Ed Engl. 2012 May 07; 51(19):4726-30.
Nicolaou KC, Hale CR, Ebner C, Nilewski C, Ahles CF, Rhoades D. PMID: 22489095; PMCID: PMC3348726.
View in:
PubMed Mentions:
5 Fields:
Translation:
Cells
-
A practical sulfenylation of 2,5-diketopiperazines. Angew Chem Int Ed Engl. 2012 Jan 16; 51(3):728-32.
Nicolaou KC, Giguère D, Totokotsopoulos S, Sun YP. PMID: 22162254; PMCID: PMC3348727.
View in:
PubMed Mentions:
15 Fields:
-
Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues. Bioorg Med Chem. 2011 Sep 15; 19(18):5648-69.
Nicolaou KC, Ellery SP, Rivas F, Saye K, Rogers E, Workinger TJ, Schallenberger M, Tawatao R, Montero A, Hessell A, Romesberg F, Carson D, Burton D. PMID: 21840722; PMCID: PMC3348725.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors. Bioorg Med Chem Lett. 2011 Sep 15; 21(18):5528-32.
Tan C, de Noronha RG, Devi NS, Jabbar AA, Kaluz S, Liu Y, Mooring SR, Nicolaou KC, Wang B, Van Meir EG. PMID: 21831638; PMCID: PMC3292863.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
-
Total synthesis of epicoccin G. J Am Chem Soc. 2011 Jun 01; 133(21):8150-3.
Nicolaou KC, Totokotsopoulos S, Giguère D, Sun YP, Sarlah D. PMID: 21548595; PMCID: PMC3102137.
View in:
PubMed Mentions:
23 Fields:
Translation:
Cells
-
Enantioselective dichlorination of allylic alcohols. J Am Chem Soc. 2011 Jun 01; 133(21):8134-7.
Nicolaou KC, Simmons NL, Ying Y, Heretsch PM, Chen JS. PMID: 21542622; PMCID: PMC3107004.
View in:
PubMed Mentions:
39 Fields:
-
Total synthesis and biological evaluation of marinopyrrole A and analogues. Tetrahedron Lett. 2011 Apr 27; 52(17):2041-2043.
Nicolaou KC, Simmons NL, Chen JS, Haste NM, Nizet V. PMID: 21499535; PMCID: PMC3077031.
View in:
PubMed Mentions:
12 Fields:
-
An expedient synthesis of a functionalized core structure of bielschowskysin. Angew Chem Int Ed Engl. 2011 May 23; 50(22):5149-52.
Nicolaou KC, Adsool VA, Hale CR. PMID: 21523870; PMCID: PMC3100894.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
Maitotoxin: An Inspiration for Synthesis. Isr J Chem. 2011 Apr; 51(3-4):359-377.
Nicolaou KC, Aversa RJ. PMID: 21709816; PMCID: PMC3119573.
View in:
PubMed Mentions:
10
-
Addressing the stereochemistry of complex organic molecules by density functional theory-NMR: vannusal B in retrospective. J Am Chem Soc. 2011 Apr 20; 133(15):6072-7.
Saielli G, Nicolaou KC, Ortiz A, Zhang H, Bagno A. PMID: 21438587; PMCID: PMC3100668.
View in:
PubMed Mentions:
25 Fields:
Translation:
Animals
-
Proteomic signature of fatty acid biosynthesis inhibition available for in vivo mechanism-of-action studies. Antimicrob Agents Chemother. 2011 Jun; 55(6):2590-6.
Wenzel M, Patra M, Albrecht D, Chen DY, Nicolaou KC, Metzler-Nolte N, Bandow JE. PMID: 21383089; PMCID: PMC3101464.
View in:
PubMed Mentions:
26 Fields:
Translation:
Cells
-
Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin. Angew Chem Int Ed Engl. 2011 Feb 01; 50(5):1139-44.
Nicolaou KC, Jiang X, Lindsay-Scott PJ, Corbu A, Yamashiro S, Bacconi A, Fowler VM. PMID: 21268213; PMCID: PMC3139707.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
Invigorating education. Angew Chem Int Ed Engl. 2011 Jan 03; 50(1):63-74.
Nicolaou KC. PMID: 21132824.
View in:
PubMed Mentions: Fields:
Translation:
Humans
-
Synthesis of the C'D'E'F' domain of maitotoxin. J Am Chem Soc. 2011 Jan 19; 133(2):214-9.
Nicolaou KC, Seo JH, Nakamura T, Aversa RJ. PMID: 21166429; PMCID: PMC3132320.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
-
Synthesis of the WXYZA' domain of maitotoxin. J Am Chem Soc. 2011 Jan 19; 133(2):220-6.
Nicolaou KC, Baker TM, Nakamura T. PMID: 21166430; PMCID: PMC3070782.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
-
Total synthesis of sporolide B and 9-epi-sporolide B. J Am Chem Soc. 2010 Aug 18; 132(32):11350-63.
Nicolaou KC, Wang J, Tang Y, Botta L. PMID: 20698702; PMCID: PMC2932487.
View in:
PubMed Mentions:
8 Fields:
-
Asymmetric total synthesis of cylindrocyclophanes A and F through cyclodimerization and a Ramberg-Bäcklund reaction. Angew Chem Int Ed Engl. 2010 Aug 09; 49(34):5875-8.
Nicolaou KC, Sun YP, Korman H, Sarlah D. PMID: 20623817; PMCID: PMC3014728.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells
-
Synthesis of the QRSTU domain of maitotoxin and its 85-epi- and 86-epi-diastereoisomers. J Am Chem Soc. 2010 Jul 21; 132(28):9900-7.
Nicolaou KC, Gelin CF, Seo JH, Huang Z, Umezawa T. PMID: 20666400; PMCID: PMC2913318.
View in:
PubMed Mentions:
10 Fields:
Translation:
Cells
-
Total synthesis and structural revision of biyouyanagin B. Chemistry. 2010 Jul 12; 16(26):7678-82.
Nicolaou KC, Sanchini S, Wu TR, Sarlah D. PMID: 20572192; PMCID: PMC3023179.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
Total synthesis of englerin A. J Am Chem Soc. 2010 Jun 16; 132(23):8219-22.
Nicolaou KC, Kang Q, Ng SY, Chen DY. PMID: 20496885.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansCells
-
Total synthesis and biological evaluation of the resveratrol-derived polyphenol natural products hopeanol and hopeahainol A. J Am Chem Soc. 2010 Jun 02; 132(21):7540-8.
Nicolaou KC, Kang Q, Wu TR, Lim CS, Chen DY. PMID: 20462209.
View in:
PubMed Mentions:
20 Fields:
-
Total synthesis and structural revision of vannusals A and B: synthesis of the true structures of vannusals A and B. J Am Chem Soc. 2010 May 26; 132(20):7153-76.
Nicolaou KC, Ortiz A, Zhang H, Guella G. PMID: 20443558; PMCID: PMC2882202.
View in:
PubMed Mentions:
14 Fields:
-
Total synthesis and structural revision of vannusals A and B: synthesis of the originally assigned structure of vannusal B. J Am Chem Soc. 2010 May 26; 132(20):7138-52.
Nicolaou KC, Ortiz A, Zhang H, Dagneau P, Lanver A, Jennings MP, Arseniyadis S, Faraoni R, Lizos DE. PMID: 20443561; PMCID: PMC2881636.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
-
Synthesis of the ABCDEFG ring system of maitotoxin. J Am Chem Soc. 2010 May 19; 132(19):6855-61.
Nicolaou KC, Aversa RJ, Jin J, Rivas F. PMID: 20415445; PMCID: PMC2880607.
View in:
PubMed Mentions:
9 Fields:
-
An expedient procedure for the oxidative cleavage of olefinic bonds with PhI(OAc)2, NMO, and catalytic OsO4. Org Lett. 2010 Apr 02; 12(7):1552-5.
Nicolaou KC, Adsool VA, Hale CR. PMID: 20192259; PMCID: PMC2848477.
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PubMed Mentions:
24 Fields:
Translation:
Cells
-
Total synthesis of echinopines A and B. J Am Chem Soc. 2010 Mar 24; 132(11):3815-8.
Nicolaou KC, Ding H, Richard JA, Chen DY. PMID: 20184316.
View in:
PubMed Mentions:
5 Fields:
-
Origins of regioselectivity of Diels-Alder reactions for the synthesis of bisanthraquinone antibiotic BE-43472B. J Org Chem. 2010 Feb 05; 75(3):922-8.
Hayden AE, Paton RS, Becker J, Lim YH, Nicolaou KC, Houk KN. PMID: 20027998; PMCID: PMC2813957.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
-
Involvement of caspase activation in azaspiracid-induced neurotoxicity in neocortical neurons. Toxicol Sci. 2010 Apr; 114(2):323-34.
Cao Z, LePage KT, Frederick MO, Nicolaou KC, Murray TF. PMID: 20047973; PMCID: PMC2840215.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
-
Total synthesis of platensimycin and related natural products. J Am Chem Soc. 2009 Nov 25; 131(46):16905-18.
Nicolaou KC, Li A, Edmonds DJ, Tria GS, Ellery SP. PMID: 19874023; PMCID: PMC2783699.
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PubMed Mentions:
18 Fields:
Translation:
Cells
-
Total syntheses of (+/-)-platencin and (-)-platencin. J Am Chem Soc. 2009 Nov 04; 131(43):15909-17.
Nicolaou KC, Tria GS, Edmonds DJ, Kar M. PMID: 19824676; PMCID: PMC2783895.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
-
Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays. Chem Biol. 2009 Oct 30; 16(10):1087-96.
Starosta AL, Qin H, Mikolajka A, Leung GY, Schwinghammer K, Nicolaou KC, Chen DY, Cooperman BS, Wilson DN. PMID: 19875082; PMCID: PMC3117328.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
-
Synthesis of functionalized maoecrystal V core structures. Chem Commun (Camb). 2010 Jan 07; 46(1):70-2.
Nicolaou KC, Dong L, Deng L, Talbot AC, Chen DY. PMID: 20024296.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
-
Total synthesis and biological evaluation of (+)- and (-)-bisanthraquinone antibiotic BE-43472B and related compounds. J Am Chem Soc. 2009 Oct 21; 131(41):14812-26.
Nicolaou KC, Becker J, Lim YH, Lemire A, Neubauer T, Montero A. PMID: 19778008; PMCID: PMC2778059.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
-
The beta-D-glucose scaffold as a beta-turn mimetic. Acc Chem Res. 2009 Oct 20; 42(10):1511-20.
Hirschmann RF, Nicolaou KC, Angeles AR, Chen JS, Smith AB. PMID: 19624154; PMCID: PMC2764824.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
-
Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons. Toxicol Sci. 2010 Jan; 113(1):158-68.
Vale C, Nicolaou KC, Frederick MO, Vieytes MR, Botana LM. PMID: 19815690; PMCID: PMC2794333.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Identification of a novel small molecule HIF-1alpha translation inhibitor. Clin Cancer Res. 2009 Oct 01; 15(19):6128-36.
Narita T, Yin S, Gelin CF, Moreno CS, Yepes M, Nicolaou KC, Van Meir EG. PMID: 19789328; PMCID: PMC2770235.
View in:
PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCells
-
Total synthesis and biological evaluation of cortistatins A and J and analogues thereof. J Am Chem Soc. 2009 Aug 05; 131(30):10587-97.
Nicolaou KC, Peng XS, Sun YP, Polet D, Zou B, Lim CS, Chen DY. PMID: 19722632.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansCells
-
Monoclonal antibodies with orthogonal azaspiracid epitopes. Chembiochem. 2009 Jul 06; 10(10):1625-9.
Frederick MO, De Lamo Marin S, Janda KD, Nicolaou KC, Dickerson TJ. PMID: 19492388; PMCID: PMC2750835.
View in:
PubMed Mentions:
6 Fields:
Translation:
Animals
-
The art of total synthesis through cascade reactions. Chem Soc Rev. 2009 Nov; 38(11):2993-3009.
Nicolaou KC, Chen JS. PMID: 19847336; PMCID: PMC2766600.
View in:
PubMed Mentions:
84 Fields:
-
Total Synthesis of Tovophyllin B. Tetrahedron Lett. 2009 Mar 18; 50(11):1161-1163.
Jeso V, Nicolaou KC. PMID: 20161287; PMCID: PMC2683023.
View in:
PubMed Mentions:
6 Fields:
-
New synthetic technologies for the construction of heterocycles and tryptamines. J Am Chem Soc. 2009 Mar 18; 131(10):3690-9.
Nicolaou KC, Krasovskiy A, Majumder U, Trépanier VE, Chen DY. PMID: 19243142.
View in:
PubMed Mentions:
1 Fields:
-
Enantioselective intramolecular Friedel-Crafts-type alpha-arylation of aldehydes. J Am Chem Soc. 2009 Feb 18; 131(6):2086-7.
Nicolaou KC, Reingruber R, Sarlah D, Bräse S. PMID: 19173649.
View in:
PubMed Mentions:
18 Fields:
Translation:
Cells
-
Inspirations, discoveries, and future perspectives in total synthesis. J Org Chem. 2009 Feb 06; 74(3):951-72.
Nicolaou KC. PMID: 19152273; PMCID: PMC2672623.
View in:
PubMed Mentions:
5 Fields:
-
Recent advances in the chemistry and biology of naturally occurring antibiotics. Angew Chem Int Ed Engl. 2009; 48(4):660-719.
Nicolaou KC, Chen JS, Edmonds DJ, Estrada AA. PMID: 19130444; PMCID: PMC2730216.
View in:
PubMed Mentions:
39 Fields:
-
Discoveries from the Abyss: The Abyssomicins and Their Total Synthesis. Synthesis (Stuttg). 2009 Jan 01; 2009(1):33-42.
Nicolaou KC, Harrison ST, Chen JS. PMID: 20047014; PMCID: PMC2677807.
View in:
PubMed Mentions:
10
-
Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11. Angew Chem Int Ed Engl. 2009; 48(47):8952-7.
Cee VJ, Chen DY, Lee MR, Nicolaou KC. PMID: 19844931.
View in:
PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
-
The true structures of the vannusals, part 1: Initial forays into suspected structures and intelligence gathering. Angew Chem Int Ed Engl. 2009; 48(31):5642-7.
Nicolaou KC, Zhang H, Ortiz A. PMID: 19562816; PMCID: PMC2777636.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
The true structures of the vannusals, part 2: Total synthesis and revised structure of vannusal B. Angew Chem Int Ed Engl. 2009; 48(31):5648-52.
Nicolaou KC, Ortiz A, Zhang H. PMID: 19562817; PMCID: PMC2772143.
View in:
PubMed Mentions:
10 Fields:
Translation:
Cells
-
Synthesis of the monomeric unit of the lomaiviticin aglycon. Angew Chem Int Ed Engl. 2009; 48(32):5860-3.
Nicolaou KC, Nold AL, Li H. PMID: 19575434; PMCID: PMC2775545.
View in:
PubMed Mentions:
15 Fields:
Translation:
Cells
-
Total synthesis of sporolide B. Angew Chem Int Ed Engl. 2009; 48(19):3449-53.
Nicolaou KC, Tang Y, Wang J. PMID: 19241430; PMCID: PMC2674522.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
-
Total synthesis and absolute configuration of the bisanthraquinone antibiotic BE-43472B. Angew Chem Int Ed Engl. 2009; 48(19):3444-8.
Nicolaou KC, Lim YH, Becker J. PMID: 19235819; PMCID: PMC2678724.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
-
Total synthesis of hopeahainol A and hopeanol. Angew Chem Int Ed Engl. 2009; 48(19):3440-3.
Nicolaou KC, Wu TR, Kang Q, Chen DY. PMID: 19280619.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Total synthesis of (+)-haplophytine. Angew Chem Int Ed Engl. 2009; 48(41):7616-20.
Nicolaou KC, Dalby SM, Li S, Suzuki T, Chen DY. PMID: 19746386.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Total synthesis of hirsutellone B. Angew Chem Int Ed Engl. 2009; 48(37):6870-4.
Nicolaou KC, Sarlah D, Wu TR, Zhan W. PMID: 19685548; PMCID: PMC2772144.
View in:
PubMed Mentions:
15 Fields:
Translation:
Cells
-
Rhodium-catalyzed asymmetric enyne cycloisomerization of terminal alkynes and formal total synthesis of (-)-platensimycin. Angew Chem Int Ed Engl. 2009; 48(34):6293-5.
Nicolaou KC, Li A, Ellery SP, Edmonds DJ. PMID: 19606433; PMCID: PMC2805260.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells
-
Samarium diiodide mediated reactions in total synthesis. Angew Chem Int Ed Engl. 2009; 48(39):7140-65.
Nicolaou KC, Ellery SP, Chen JS. PMID: 19714695; PMCID: PMC2771673.
View in:
PubMed Mentions:
66 Fields:
Translation:
Cells
-
From nature to the laboratory and into the clinic. Bioorg Med Chem. 2009 Mar 15; 17(6):2290-303.
Nicolaou KC, Chen JS, Dalby SM. PMID: 19028103; PMCID: PMC2665039.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimals
-
A concise asymmetric total synthesis of aspidophytine. J Am Chem Soc. 2008 Nov 12; 130(45):14942-3.
Nicolaou KC, Dalby SM, Majumder U. PMID: 18855359.
View in:
PubMed Mentions:
10 Fields:
Translation:
Cells
-
Cytotoxic effect of azaspiracid-2 and azaspiracid-2-methyl ester in cultured neurons: involvement of the c-Jun N-terminal kinase. J Neurosci Res. 2008 Oct; 86(13):2952-62.
Vale C, Wandscheer C, Nicolaou KC, Frederick MO, Alfonso C, Vieytes MR, Botana LM. PMID: 18500761.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity. J Am Chem Soc. 2008 Oct 01; 130(39):13110-9.
Nicolaou KC, Stepan AF, Lister T, Li A, Montero A, Tria GS, Turner CI, Tang Y, Wang J, Denton RM, Edmonds DJ. PMID: 18771264; PMCID: PMC2669665.
View in:
PubMed Mentions:
28 Fields:
Translation:
Cells
-
Azaspiracid substituent at C1 is relevant to in vitro toxicity. Chem Res Toxicol. 2008 Sep; 21(9):1823-31.
Vilariño N, Nicolaou KC, Frederick MO, Cagide E, Alfonso C, Alonso E, Vieytes MR, Botana LM. PMID: 18707138; PMCID: PMC2559976.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
-
An expedient asymmetric synthesis of platencin. J Am Chem Soc. 2008 Aug 27; 130(34):11292-3.
Nicolaou KC, Toh QY, Chen DY. PMID: 18665593.
View in:
PubMed Mentions:
14 Fields:
-
Total synthesis, revised structure, and biological evaluation of biyouyanagin A and analogues thereof. J Am Chem Soc. 2008 Aug 20; 130(33):11114-21.
Nicolaou KC, Wu TR, Sarlah D, Shaw DM, Rowcliffe E, Burton DR. PMID: 18646750; PMCID: PMC2614900.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
-
Chemical synthesis and biological evaluation of palmerolide A analogues. J Am Chem Soc. 2008 Jul 30; 130(30):10019-23.
Nicolaou KC, Leung GY, Dethe DH, Guduru R, Sun YP, Lim CS, Chen DY. PMID: 18598030.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
Total synthesis of atrochamins F, H, I, and J through cascade reactions. Tetrahedron. 2008 May 19; 64(21):4736-4757.
Nicolaou KC, Lister T, Denton RM, Gelin CF. PMID: 19461992; PMCID: PMC2597834.
View in:
PubMed Mentions:
5 Fields:
-
Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin. J Am Chem Soc. 2008 Jun 11; 130(23):7466-76.
Nicolaou KC, Frederick MO, Burtoloso AC, Denton RM, Rivas F, Cole KP, Aversa RJ, Gibe R, Umezawa T, Suzuki T. PMID: 18481856.
View in:
PubMed Mentions:
18 Fields:
-
Total syntheses of amythiamicins A, B and C. Chem Commun (Camb). 2008 Jun 21; (23):2632-4.
Nicolaou KC, Dethe DH, Chen DY. PMID: 18535690.
View in:
PubMed Mentions:
4 Fields:
-
Total synthesis of the originally proposed and revised structures of palmerolide A and isomers thereof. J Am Chem Soc. 2008 Mar 19; 130(11):3633-44.
Nicolaou KC, Sun YP, Guduru R, Banerji B, Chen DY. PMID: 18298117.
View in:
PubMed Mentions:
10 Fields:
Translation:
Cells
-
Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1. Chem Asian J. 2008 Feb 01; 3(2):413-29.
Nicolaou KC, Dethe DH, Leung GY, Zou B, Chen DY. PMID: 18188863.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
-
Total synthesis of platencin. Angew Chem Int Ed Engl. 2008; 47(9):1780-3.
Nicolaou KC, Tria GS, Edmonds DJ. PMID: 18246566.
View in:
PubMed Mentions:
20 Fields:
Translation:
Cells
-
Asymmetric synthesis and biological properties of uncialamycin and 26-epi-uncialamycin. Angew Chem Int Ed Engl. 2008; 47(1):185-9.
Nicolaou KC, Chen JS, Zhang H, Montero A. PMID: 18058881.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
A chiral pool based synthesis of platensimycin. Angew Chem Int Ed Engl. 2008; 47(5):944-6.
Nicolaou KC, Pappo D, Tsang KY, Gibe R, Chen DY. PMID: 18176919.
View in:
PubMed Mentions:
10 Fields:
Translation:
Cells
-
An expedient strategy for the synthesis of tryptamines and other heterocycles. Angew Chem Int Ed Engl. 2008; 47(22):4217-20.
Nicolaou KC, Krasovskiy A, Trépanier VE, Chen DY. PMID: 18404758.
View in:
PubMed Mentions:
1 Fields:
-
Total synthesis of the originally assigned structure of vannusal B. Angew Chem Int Ed Engl. 2008; 47(45):8605-10.
Nicolaou KC, Zhang H, Ortiz A, Dagneau P. PMID: 18850598; PMCID: PMC2790063.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Total syntheses and structural revision of alpha- and beta-diversonolic esters and total syntheses of diversonol and blennolide C. Angew Chem Int Ed Engl. 2008; 47(35):6579-82.
Nicolaou KC, Li A. PMID: 18651685; PMCID: PMC2790823.
View in:
PubMed Mentions:
17 Fields:
Translation:
Cells
-
Total synthesis of (+)-cortistatin A. Angew Chem Int Ed Engl. 2008; 47(38):7310-3.
Nicolaou KC, Sun YP, Peng XS, Polet D, Chen DY. PMID: 18704899.
View in:
PubMed Mentions:
19 Fields:
-
The continuing saga of the marine polyether biotoxins. Angew Chem Int Ed Engl. 2008; 47(38):7182-225.
Nicolaou KC, Frederick MO, Aversa RJ. PMID: 18763702; PMCID: PMC2730226.
View in:
PubMed Mentions:
48 Fields:
Translation:
AnimalsCells
-
Synthesis of the sporolide ring framework through a cascade sequence involving an intramolecular [4+2] cycloaddition reaction of an o-quinone. Angew Chem Int Ed Engl. 2008; 47(8):1432-5.
Nicolaou KC, Wang J, Tang Y. PMID: 18205155.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
Total synthesis and antibacterial properties of carbaplatensimycin. J Am Chem Soc. 2007 Dec 05; 129(48):14850-1.
Nicolaou KC, Tang Y, Wang J, Stepan AF, Li A, Montero A. PMID: 17988130.
View in:
PubMed Mentions:
21 Fields:
Translation:
Cells
-
Total synthesis of kinamycins C, F, and J. J Am Chem Soc. 2007 Aug 29; 129(34):10356-7.
Nicolaou KC, Li H, Nold AL, Pappo D, Lenzen A. PMID: 17676854.
View in:
PubMed Mentions:
18 Fields:
Translation:
Cells
-
New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems. Tetrahedron. 2007 Jul 02; 63(27):6088-6114.
Nicolaou KC, Estrada AA, Freestone GC, Lee SH, Alvarez-Mico X. PMID: 20606766; PMCID: PMC2896327.
View in:
PubMed Mentions:
4 Fields:
-
Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells. Biochem Pharmacol. 2007 Jul 15; 74(2):327-35.
Vilariño N, Nicolaou KC, Frederick MO, Vieytes MR, Botana LM. PMID: 17485074.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
The chemistry and biology of epothilones--the wheel keeps turning. ChemMedChem. 2007 Apr; 2(4):396-423.
Altmann KH, Pfeiffer B, Arseniyadis S, Pratt BA, Nicolaou KC. PMID: 17340668.
View in:
PubMed Mentions:
26 Fields:
Translation:
Cells
-
Total syntheses of 2,2'-epi-cytoskyrin A, rugulosin, and the alleged structure of rugulin. J Am Chem Soc. 2007 Apr 04; 129(13):4001-13.
Nicolaou KC, Lim YH, Piper JL, Papageorgiou CD. PMID: 17355133.
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PubMed Mentions:
19 Fields:
Translation:
Cells
-
Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study. J Med Chem. 2007 Jan 25; 50(2):356-63.
Vale C, Nicolaou KC, Frederick MO, Gómez-Limia B, Alfonso A, Vieytes MR, Botana LM. PMID: 17228878.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
Total synthesis of marinomycins A-C and of their monomeric counterparts monomarinomycin A and iso-monomarinomycin A. J Am Chem Soc. 2007 Feb 14; 129(6):1760-8.
Nicolaou KC, Nold AL, Milburn RR, Schindler CS, Cole KP, Yamaguchi J. PMID: 17249678.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
Total synthesis of abyssomicin C, atrop-abyssomicin C, and abyssomicin D: implications for natural origins of atrop-abyssomicin C. J Am Chem Soc. 2007 Jan 17; 129(2):429-40.
Nicolaou KC, Harrison ST. PMID: 17212423.
View in:
PubMed Mentions:
26 Fields:
Translation:
Cells
-
On the structure of maitotoxin. Angew Chem Int Ed Engl. 2007; 46(28):5278-82.
Nicolaou KC, Frederick MO. PMID: 17469088.
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PubMed Mentions:
16 Fields:
Translation:
Cells
-
Adamantaplatensimycin: a bioactive analogue of platensimycin. Angew Chem Int Ed Engl. 2007; 46(25):4712-4.
Nicolaou KC, Lister T, Denton RM, Montero A, Edmonds DJ. PMID: 17514775.
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PubMed Mentions:
28 Fields:
Translation:
Cells
-
The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1. Cell Physiol Biochem. 2007; 20(6):957-66.
Vale C, Gómez-Limia B, Nicolaou KC, Frederick MO, Vieytes MR, Botana LM. PMID: 17982278.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
Chemical synthesis of the GHIJK ring system and further experimental support for the originally assigned structure of maitotoxin. Angew Chem Int Ed Engl. 2007; 46(46):8875-9.
Nicolaou KC, Cole KP, Frederick MO, Aversa RJ, Denton RM. PMID: 17943950.
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PubMed Mentions:
15 Fields:
Translation:
Cells
-
Total synthesis of the originally proposed and revised structures of palmerolide A. Angew Chem Int Ed Engl. 2007; 46(31):5896-900.
Nicolaou KC, Guduru R, Sun YP, Banerji B, Chen DY. PMID: 17600809.
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PubMed Mentions:
13 Fields:
Translation:
Cells
-
Total synthesis and stereochemistry of uncialamycin. Angew Chem Int Ed Engl. 2007; 46(25):4704-7.
Nicolaou KC, Zhang H, Chen JS, Crawford JJ, Pasunoori L. PMID: 17497617.
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PubMed Mentions:
15 Fields:
Translation:
Cells
-
Asymmetric total syntheses of platensimycin. Angew Chem Int Ed Engl. 2007; 46(21):3942-5.
Nicolaou KC, Edmonds DJ, Li A, Tria GS. PMID: 17444571.
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PubMed Mentions:
20 Fields:
Translation:
Cells
-
Total synthesis and revised structure of biyouyanagin A. Angew Chem Int Ed Engl. 2007; 46(25):4708-11.
Nicolaou KC, Sarlah D, Shaw DM. PMID: 17523208.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
Construction of the "left domain" of haplophytine. Angew Chem Int Ed Engl. 2007; 46(25):4715-8.
Nicolaou KC, Majumder U, Roche SP, Chen DY. PMID: 17559182.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Cascade reactions involving formal [2+2] thermal cycloadditions: total synthesis of artochamins F, H, I, and J. Angew Chem Int Ed Engl. 2007; 46(39):7501-5.
Nicolaou KC, Lister T, Denton RM, Gelin CF. PMID: 17768746.
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PubMed Mentions:
4 Fields:
Translation:
Cells
-
Total synthesis of antibiotics GE2270A and GE2270T. Angew Chem Int Ed Engl. 2006 Nov 27; 45(46):7786-92.
Nicolaou KC, Zou B, Dethe DH, Li DB, Chen DY. PMID: 17061302.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells
-
Cascade reactions in total synthesis. Angew Chem Int Ed Engl. 2006 Nov 06; 45(43):7134-86.
Nicolaou KC, Edmonds DJ, Bulger PG. PMID: 17075967.
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PubMed Mentions:
182 Fields:
Translation:
Cells
-
Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies. Chem Res Toxicol. 2006 Nov; 19(11):1459-66.
Vilariño N, Nicolaou KC, Frederick MO, Cagide E, Ares IR, Louzao MC, Vieytes MR, Botana LM. PMID: 17112233.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
Total synthesis of platensimycin. Angew Chem Int Ed Engl. 2006 Oct 27; 45(42):7086-90.
Nicolaou KC, Li A, Edmonds DJ. PMID: 17013803.
View in:
PubMed Mentions:
27 Fields:
-
Total synthesis of marinomycins A-C. Angew Chem Int Ed Engl. 2006 Oct 06; 45(39):6527-32.
Nicolaou KC, Nold AL, Milburn RR, Schindler CS. PMID: 16977657.
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PubMed Mentions:
6 Fields:
Translation:
Cells
-
Synthesis of highly substituted N-hydroxyindoles through 1,5-addition of carbon nucleophiles to in situ generated unsaturated nitrones. Angew Chem Int Ed Engl. 2006 Aug 11; 45(32):5364-8.
Nicolaou KC, Estrada AA, Lee SH, Freestone GC. PMID: 16847981.
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PubMed Mentions:
4 Fields:
Translation:
Cells
-
Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. Mol Pharmacol. 2006 Nov; 70(5):1555-64.
Hamel E, Day BW, Miller JH, Jung MK, Northcote PT, Ghosh AK, Curran DP, Cushman M, Nicolaou KC, Paterson I, Sorensen EJ. PMID: 16887932.
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PubMed Mentions:
39 Fields:
Translation:
HumansCells
-
Second-generation total synthesis of azaspiracids-1, -2, and -3. Chem Asian J. 2006 Jul 17; 1(1-2):245-63.
Nicolaou KC, Frederick MO, Loizidou EZ, Petrovic G, Cole KP, Koftis TV, Yamada YM. PMID: 17441061.
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PubMed Mentions:
9 Fields:
Translation:
Cells
-
Azaspiracids modulate intracellular pH levels in human lymphocytes. Biochem Biophys Res Commun. 2006 Aug 04; 346(3):1091-9.
Alfonso A, Vieytes MR, Ofuji K, Satake M, Nicolaou KC, Frederick MO, Botana LM. PMID: 16793022.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
Total synthesis of abyssomicin C and atrop-abyssomicin C. Angew Chem Int Ed Engl. 2006 May 12; 45(20):3256-60.
Nicolaou KC, Harrison ST. PMID: 16634106.
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PubMed Mentions:
25 Fields:
Translation:
Cells
-
Synthesis of iso-epoxy-amphidinolide N and des-epoxy-caribenolide I structures. Revised strategy and final stages. Org Biomol Chem. 2006 Jun 07; 4(11):2158-83.
Nicolaou KC, Bulger PG, Brenzovich WE. PMID: 16729127.
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PubMed Mentions:
4 Fields:
-
Synthesis of iso-epoxy-amphidinolide N and des-epoxy-caribenolide I structures. Initial forays. Org Biomol Chem. 2006 Jun 07; 4(11):2119-57.
Nicolaou KC, Brenzovich WE, Bulger PG, Francis TM. PMID: 16729126.
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PubMed Mentions:
8 Fields:
-
Total synthesis and confirmation of the revised structures of azaspiracid-2 and azaspiracid-3. Angew Chem Int Ed Engl. 2006 Apr 10; 45(16):2609-15.
Nicolaou KC, Frederick MO, Petrovic G, Cole KP, Loizidou EZ. PMID: 16548033.
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PubMed Mentions:
13 Fields:
Translation:
Cells
-
Total synthesis and biological evaluation of halipeptins A and D and analogues. J Am Chem Soc. 2006 Apr 05; 128(13):4460-70.
Nicolaou KC, Lizos DE, Kim DW, Schlawe D, de Noronha RG, Longbottom DA, Rodriquez M, Bucci M, Cirino G. PMID: 16569024.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
Stereocontrolled synthesis of model core systems of lomaiviticins A and B. Angew Chem Int Ed Engl. 2006 Mar 20; 45(13):2076-81.
Nicolaou KC, Denton RM, Lenzen A, Edmonds DJ, Li A, Milburn RR, Harrison ST. PMID: 16496276.
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PubMed Mentions:
15 Fields:
Translation:
Cells
-
Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1. J Am Chem Soc. 2006 Mar 08; 128(9):2859-72.
Nicolaou KC, Koftis TV, Vyskocil S, Petrovic G, Tang W, Frederick MO, Chen DY, Li Y, Ling T, Yamada YM. PMID: 16506764.
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PubMed Mentions:
17 Fields:
Translation:
Animals
-
Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product. J Am Chem Soc. 2006 Feb 22; 128(7):2258-67.
Nicolaou KC, Chen DY, Li Y, Uesaka N, Petrovic G, Koftis TV, Bernal F, Frederick MO, Govindasamy M, Ling T, Pihko PM, Tang W, Vyskocil S. PMID: 16478179.
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PubMed Mentions:
12 Fields:
Translation:
Cells
-
Total synthesis and structural elucidation of azaspiracid-1. Construction of key building blocks for originally proposed structure. J Am Chem Soc. 2006 Feb 22; 128(7):2244-57.
Nicolaou KC, Pihko PM, Bernal F, Frederick MO, Qian W, Uesaka N, Diedrichs N, Hinrichs J, Koftis TV, Loizidou E, Petrovic G, Rodriquez M, Sarlah D, Zou N. PMID: 16478178.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
-
Molecular design and chemical synthesis of a highly potent epothilone. ChemMedChem. 2006 Jan; 1(1):41-4.
Nicolaou KC, Pratt BA, Arseniyadis S, Wartmann M, O'Brate A, Giannakakou P. PMID: 16892332.
View in:
PubMed Mentions:
8 Fields:
-
Total synthesis of (+)-rugulosin and (+)-2,2'-epi-cytoskyrin A through cascade reactions. Angew Chem Int Ed Engl. 2005 Dec 09; 44(48):7917-21.
Nicolaou KC, Lim YH, Papageorgiou CD, Piper JL. PMID: 16342134.
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PubMed Mentions:
8 Fields:
Translation:
Cells
-
Discovery of a biologically active thiostrepton fragment. J Am Chem Soc. 2005 Nov 02; 127(43):15042-4.
Nicolaou KC, Zak M, Rahimipour S, Estrada AA, Lee SH, O'Brate A, Giannakakou P, Ghadiri MR. PMID: 16248640.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
-
Total synthesis of halipeptins: isolation of halipeptin D and synthesis of oxazoline halipeptin analogues. Chemistry. 2005 Oct 21; 11(21):6197-211.
Nicolaou KC, Schlawe D, Kim DW, Longbottom DA, de Noronha RG, Lizos DE, Manam RR, Faulkner DJ. PMID: 16075448.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Synthesis of imides, N-acyl vinylogous carbamates and ureas, and nitriles by oxidation of amides and amines with Dess-Martin periodinane. Angew Chem Int Ed Engl. 2005 Sep 19; 44(37):5992-7.
Nicolaou KC, Mathison CJ. PMID: 16124020.
View in:
PubMed Mentions:
16 Fields:
Translation:
Cells
-
The cytoskyrin cascade: a facile entry into cytoskyrin A, deoxyrubroskyrin, rugulin, skyrin, and flavoskyrin model systems. Angew Chem Int Ed Engl. 2005 Sep 12; 44(36):5846-51.
Nicolaou KC, Papageorgiou CD, Piper JL, Chadha RK. PMID: 16123947.
View in:
PubMed Mentions:
7 Fields:
-
Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. J Med Chem. 2005 Sep 08; 48(18):5613-38.
Nicolaou KC. PMID: 16134928.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
-
Joys of molecules. 1. Campaigns in total synthesis. J Org Chem. 2005 Sep 02; 70(18):7007-27.
Nicolaou KC. PMID: 16122219.
View in:
PubMed Mentions:
2 Fields:
-
Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks. J Am Chem Soc. 2005 Aug 10; 127(31):11159-75.
Nicolaou KC, Safina BS, Zak M, Lee SH, Nevalainen M, Bella M, Estrada AA, Funke C, Zécri FJ, Bulat S. PMID: 16076224.
View in:
PubMed Mentions:
19 Fields:
Translation:
Cells
-
Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis. J Am Chem Soc. 2005 Aug 10; 127(31):11176-83.
Nicolaou KC, Zak M, Safina BS, Estrada AA, Lee SH, Nevalainen M. PMID: 16076225.
View in:
PubMed Mentions:
20 Fields:
-
Total synthesis of halipeptins A and D and analogues. Angew Chem Int Ed Engl. 2005 Aug 05; 44(31):4925-9.
Nicolaou KC, Kim DW, Schlawe D, Lizos DE, de Noronha RG, Longbottom DA. PMID: 16010700.
View in:
PubMed Mentions:
1 Fields:
Translation:
Cells
-
Metathesis reactions in total synthesis. Angew Chem Int Ed Engl. 2005 Jul 18; 44(29):4490-527.
Nicolaou KC, Bulger PG, Sarlah D. PMID: 16003791.
View in:
PubMed Mentions:
132 Fields:
Translation:
Cells
-
Palladium-catalyzed cross-coupling reactions in total synthesis. Angew Chem Int Ed Engl. 2005 Jul 18; 44(29):4442-89.
Nicolaou KC, Bulger PG, Sarlah D. PMID: 15991198.
View in:
PubMed Mentions:
246 Fields:
Translation:
Cells
-
The total synthesis of coleophomones B, C, and D. J Am Chem Soc. 2005 Jun 22; 127(24):8872-88.
Nicolaou KC, Montagnon T, Vassilikogiannakis G, Mathison CJ. PMID: 15954796.
View in:
PubMed Mentions:
17 Fields:
Translation:
Cells
-
A catalytic asymmetric three-component 1,4-addition/aldol reaction: enantioselective synthesis of the spirocyclic system of vannusal A. Angew Chem Int Ed Engl. 2005 Jun 20; 44(25):3874-9.
Nicolaou KC, Tang W, Dagneau P, Faraoni R. PMID: 15900527.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
-
Construction of highly functionalized medium-sized rings: synthesis of hyperforin and perforatumone model systems. Angew Chem Int Ed Engl. 2005 Jun 20; 44(25):3895-9.
Nicolaou KC, Carenzi GE, Jeso V. PMID: 15892032.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system. Angew Chem Int Ed Engl. 2005 Jun 13; 44(24):3736-40.
Nicolaou KC, Lee SH, Estrada AA, Zak M. PMID: 15892095.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
Studies toward the synthesis of azadirachtin, part 1: total synthesis of a fully functionalized ABC ring framework and coupling with a norbornene domain. Angew Chem Int Ed Engl. 2005 May 30; 44(22):3443-7.
Nicolaou KC, Sasmal PK, Roecker AJ, Sun XW, Mandal S, Converso A. PMID: 15846829.
View in:
PubMed Mentions:
3 Fields:
Translation:
Cells
-
Studies toward the synthesis of azadirachtin, part 2: construction of fully functionalized ABCD ring frameworks and unusual intramolecular reactions induced by close-proximity effects. Angew Chem Int Ed Engl. 2005 May 30; 44(22):3447-52.
Nicolaou KC, Sasmal PK, Koftis TV, Converso A, Loizidou E, Kaiser F, Roecker AJ, Dellios CC, Sun XW, Petrovic G. PMID: 15849805.
View in:
PubMed Mentions:
3 Fields:
Translation:
Cells
-
A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide. Angew Chem Int Ed Engl. 2005 Feb 18; 44(9):1378-82.
Nicolaou KC, Estrada AA, Zak M, Lee SH, Safina BS. PMID: 15674985.
View in:
PubMed Mentions:
74 Fields:
Translation:
Cells
-
Chasing molecules that were never there: misassigned natural products and the role of chemical synthesis in modern structure elucidation. Angew Chem Int Ed Engl. 2005 Feb 04; 44(7):1012-1044.
Nicolaou KC, Snyder SA. PMID: 15688428.
View in:
PubMed Mentions:
108 Fields:
Translation:
HumansCells
-
Biomimetic total synthesis of gambogin and rate acceleration of pericyclic reactions in aqueous media. Angew Chem Int Ed Engl. 2005 Jan 21; 44(5):756-61.
Nicolaou KC, Xu H, Wartmann M. PMID: 15657969.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway. Cancer Res. 2005 Jan 15; 65(2):605-12.
Tan C, de Noronha RG, Roecker AJ, Pyrzynska B, Khwaja F, Zhang Z, Zhang H, Teng Q, Nicholson AC, Giannakakou P, Zhou W, Olson JJ, Pereira MM, Nicolaou KC, Van Meir EG. PMID: 15695405.
View in:
PubMed Mentions:
57 Fields:
Translation:
HumansCells
-
New uses for the Burgess reagent in chemical synthesis: methods for the facile and stereoselective formation of sulfamidates, glycosylamines, and sulfamides. Chemistry. 2004 Nov 05; 10(22):5581-606.
Nicolaou KC, Snyder SA, Longbottom DA, Nalbandian AZ, Huang X. PMID: 15470695.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
-
Chemistry and biology of diazonamide A: first total synthesis and confirmation of the true structure. J Am Chem Soc. 2004 Oct 13; 126(40):12888-96.
Nicolaou KC, Chen DY, Huang X, Ling T, Bella M, Snyder SA. PMID: 15469286.
View in:
PubMed Mentions:
24 Fields:
Translation:
Cells
-
Chemistry and biology of diazonamide A: second total synthesis and biological investigations. J Am Chem Soc. 2004 Oct 13; 126(40):12897-906.
Nicolaou KC, Hao J, Reddy MV, Rao PB, Rassias G, Snyder SA, Huang X, Chen DY, Brenzovich WE, Giuseppone N, O'Brate A, Giannakakou P. PMID: 15469287.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
-
Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle. Angew Chem Int Ed Engl. 2004 Sep 27; 43(38):5087-92.
Nicolaou KC, Safina BS, Zak M, Estrada AA, Lee SH. PMID: 15372631.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells
-
Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis. Angew Chem Int Ed Engl. 2004 Sep 27; 43(38):5092-7.
Nicolaou KC, Zak M, Safina BS, Lee SH, Estrada AA. PMID: 15372630.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
-
Structural revision and total synthesis of azaspiracid-1, part 1: intelligence gathering and tentative proposal. Angew Chem Int Ed Engl. 2004 Aug 20; 43(33):4312-8.
Nicolaou KC, Vyskocil S, Koftis TV, Yamada YM, Ling T, Chen DY, Tang W, Petrovic G, Frederick MO, Li Y, Satake M. PMID: 15368380.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
-
Structural revision and total synthesis of azaspiracid-1, part 2: definition of the ABCD domain and total synthesis. Angew Chem Int Ed Engl. 2004 Aug 20; 43(33):4318-24.
Nicolaou KC, Koftis TV, Vyskocil S, Petrovic G, Ling T, Yamada YM, Tang W, Frederick MO. PMID: 15368381.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Studies toward diazonamide A: initial synthetic forays directed toward the originally proposed structure. J Am Chem Soc. 2004 Aug 18; 126(32):10162-73.
Nicolaou KC, Snyder SA, Huang X, Simonsen KB, Koumbis AE, Bigot A. PMID: 15303892.
View in:
PubMed Mentions:
10 Fields:
-
Studies toward diazonamide A: development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure. J Am Chem Soc. 2004 Aug 18; 126(32):10174-82.
Nicolaou KC, Snyder SA, Giuseppone N, Huang X, Bella M, Reddy MV, Rao PB, Koumbis AE, O'Brate A, Giannakakou P. PMID: 15303893.
View in:
PubMed Mentions:
7 Fields:
Translation:
Cells
-
A new method for the stereoselective synthesis of alpha- and beta-glycosylamines using the Burgess reagent. J Am Chem Soc. 2004 May 26; 126(20):6234-5.
Nicolaou KC, Snyder SA, Nalbandian AZ, Longbottom DA. PMID: 15149212.
View in:
PubMed Mentions:
3 Fields:
-
Biomimetically inspired total synthesis and structure activity relationships of 1-O-methyllateriflorone. 6 pi electrocyclizations in organic synthesis. J Am Chem Soc. 2004 May 05; 126(17):5493-501.
Nicolaou KC, Sasmal PK, Xu H. PMID: 15113221.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
o-Iodoxybenzoic acid (IBX) as a viable reagent in the manipulation of nitrogen- and sulfur-containing substrates: scope, generality, and mechanism of IBX-mediated amine oxidations and dithiane deprotections. J Am Chem Soc. 2004 Apr 28; 126(16):5192-201.
Nicolaou KC, Mathison CJ, Montagnon T. PMID: 15099102.
View in:
PubMed Mentions:
27 Fields:
Translation:
Cells
-
Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity. Chem Biol. 2004 Feb; 11(2):225-36.
Buey RM, Díaz JF, Andreu JM, O'Brate A, Giannakakou P, Nicolaou KC, Sasmal PK, Ritzén A, Namoto K. PMID: 15123284.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansCells
-
Total synthesis of hamigerans and analogues thereof. Photochemical generation and Diels-Alder trapping of hydroxy-o-quinodimethanes. J Am Chem Soc. 2004 Jan 21; 126(2):613-27.
Nicolaou KC, Gray DL, Tae J. PMID: 14719961.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
-
Total synthesis of hybocarpone and analogues thereof. A facile dimerization of naphthazarins to pentacyclic systems. J Am Chem Soc. 2004 Jan 21; 126(2):607-12.
Nicolaou KC, Gray DL. PMID: 14719960.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
-
Total synthesis of apoptolidin: completion of the synthesis and analogue synthesis and evaluation. J Am Chem Soc. 2003 Dec 17; 125(50):15443-54.
Nicolaou KC, Li Y, Sugita K, Monenschein H, Guntupalli P, Mitchell HJ, Fylaktakidou KC, Vourloumis D, Giannakakou P, O'Brate A. PMID: 14664590.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
-
Total synthesis of apoptolidin: construction of enantiomerically pure fragments. J Am Chem Soc. 2003 Dec 17; 125(50):15433-42.
Nicolaou KC, Fylaktakidou KC, Monenschein H, Li Y, Weyershausen B, Mitchell HJ, Wei HX, Guntupalli P, Hepworth D, Sugita K. PMID: 14664589.
View in:
PubMed Mentions:
14 Fields:
-
Total synthesis and biological evaluation of (-)apicularen A and analogues thereof. Chemistry. 2003 Dec 15; 9(24):6177-91.
Nicolaou KC, Kim DW, Baati R, O'Brate A, Giannakakou P. PMID: 14679529.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Total synthesis of 1-O-methyllateriflorone. Angew Chem Int Ed Engl. 2003 Sep 15; 42(35):4225-9.
Nicolaou KC, Sasmal PK, Xu H, Namoto K, Ritzén A. PMID: 14502742.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
New reactions of IBX: oxidation of nitrogen- and sulfur-containing substrates to afford useful synthetic intermediates. Angew Chem Int Ed Engl. 2003 Sep 05; 42(34):4077-82.
Nicolaou KC, Mathison CJ, Montagnon T. PMID: 12973775.
View in:
PubMed Mentions:
17 Fields:
Translation:
Cells
-
Total synthesis of the proposed azaspiracid-1 structure, part 1: construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments. Angew Chem Int Ed Engl. 2003 Aug 11; 42(31):3643-8.
Nicolaou KC, Li Y, Uesaka N, Koftis TV, Vyskocil S, Ling T, Govindasamy M, Qian W, Bernal F, Chen DY. PMID: 12916036.
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13 Fields:
Translation:
Cells
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Total synthesis of the proposed azaspiracid-1 structure, part 2: coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis. Angew Chem Int Ed Engl. 2003 Aug 11; 42(31):3649-53.
Nicolaou KC, Chen DY, Li Y, Qian W, Ling T, Vyskocil S, Koftis TV, Govindasamy M, Uesaka N. PMID: 12916037.
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12 Fields:
Translation:
Cells
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Studies towards the synthesis of azadirachtin: enantioselective entry into the azadirachtin framework through cascade reactions. Angew Chem Int Ed Engl. 2003 Aug 11; 42(31):3637-42.
Nicolaou KC, Roecker AJ, Monenschein H, Guntupalli P, Follmann M. PMID: 12916035.
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Cells
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Design, synthesis, and biological properties of highly potent epothilone B analogues. Angew Chem Int Ed Engl. 2003 Aug 04; 42(30):3515-20.
Nicolaou KC, Sasmal PK, Rassias G, Reddy MV, Altmann KH, Wartmann M, O'Brate A, Giannakakou P. PMID: 12900969.
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8 Fields:
Translation:
HumansCells
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Synthetic studies on thiostrepton: construction of thiostrepton analogues with the thiazoline-containing macrocycle. Angew Chem Int Ed Engl. 2003 Jul 28; 42(29):3418-24.
Nicolaou KC, Nevalainen M, Zak M, Bulat S, Bella M, Safina BS. PMID: 12888975.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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The second total synthesis of diazonamide A. Angew Chem Int Ed Engl. 2003 Apr 17; 42(15):1753-8.
Nicolaou KC, Bheema Rao P, Hao J, Reddy MV, Rassias G, Huang X, Chen DY, Snyder SA. PMID: 12707898.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr; 11(4):1079-92.
Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM. PMID: 12718892; PMCID: PMC6179153.
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131 Fields:
Translation:
HumansAnimalsCells
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Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org Biomol Chem. 2003 Mar 21; 1(6):908-20.
Nicolaou KC, Evans RM, Roecker AJ, Hughes R, Downes M, Pfefferkorn JA. PMID: 12929628.
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14 Fields:
Translation:
Cells
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Profile. K. C. Nicolaou. Org Biomol Chem. 2003 Mar 21; 1(6):x-xi.
Nicolaou KC. PMID: 12929625.
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Tandem reactions, cascade sequences, and biomimetic strategies in total synthesis. Chem Commun (Camb). 2003 Mar 07; (5):551-64.
Nicolaou KC, Montagnon T, Snyder SA. PMID: 12669826.
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48 Fields:
Translation:
Cells
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Novel strategies for the solid phase synthesis of substituted indolines and indoles. Bioorg Med Chem. 2003 Feb 06; 11(3):465-76.
Nicolaou KC, Roecker AJ, Hughes R, van Summeren R, Pfefferkorn JA, Winssinger N. PMID: 12517442.
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1 Fields:
Translation:
Cells
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Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. Cancer Res. 2002 Dec 01; 62(23):6938-43.
Bocci G, Nicolaou KC, Kerbel RS. PMID: 12460910.
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128 Fields:
Translation:
HumansCells
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A new method for the synthesis of nonsymmetrical sulfamides using burgess-type reagents. Angew Chem Int Ed Engl. 2002 Oct 18; 41(20):3866-70.
Nicolaou KC, Longbottom DA, Snyder SA, Nalbanadian AZ, Huang X. PMID: 12386873.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Stereocontrolled total synthesis of apicularen A and its delta(17,18) Z isomer. Angew Chem Int Ed Engl. 2002 Oct 04; 41(19):3701-4; 3523.
Nicolaou KC, Kim DW, Baati R. PMID: 12370936.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Total synthesis of diazonamide A. Angew Chem Int Ed Engl. 2002 Sep 16; 41(18):3495-9.
Nicolaou KC, Bella M, Chen DY, Huang X, Ling T, Snyder SA. PMID: 12298077.
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20 Fields:
Translation:
AnimalsCells
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Atropselective macrocyclization of diaryl ether ring systems: application to the synthesis of vancomycin model systems. J Am Chem Soc. 2002 Sep 04; 124(35):10451-5.
Nicolaou KC, Boddy CN. PMID: 12197747.
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10 Fields:
Translation:
Cells
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Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase. Bioorg Med Chem Lett. 2002 Sep 02; 12(17):2487-90.
Nicholas GM, Eckman LL, Ray S, Hughes RO, Pfefferkorn JA, Barluenga S, Nicolaou KC, Bewley CA. PMID: 12161164.
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15 Fields:
Translation:
Cells
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The total synthesis of coleophomones B and C. Angew Chem Int Ed Engl. 2002 Sep 02; 41(17):3276-81.
Nicolaou KC, Vassilikogiannakis G, Montagnon T. PMID: 12207414.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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A novel 2'-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models. Bioconjug Chem. 2002 Sep-Oct; 13(5):1093-9.
Wrasidlo W, Gaedicke G, Guy RK, Renaud J, Pitsinos E, Nicolaou KC, Reisfeld RA, Lode HN. PMID: 12236791.
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12 Fields:
Translation:
HumansAnimalsCells
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The CP molecule labyrinth: a paradigm of how endeavors in total synthesis lead to discoveries and inventions in organic synthesis. Angew Chem Int Ed Engl. 2002 Aug 02; 41(15):2678-720.
Nicolaou KC, Baran PS. PMID: 12203464.
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5 Fields:
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Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10855-60.
Giannakakou P, Nakano M, Nicolaou KC, O'Brate A, Yu J, Blagosklonny MV, Greber UF, Fojo T. PMID: 12145320; PMCID: PMC125062.
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75 Fields:
Translation:
HumansCells
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Model studies towards azadirachtin: part 2. Construction of the crowded C8-C14 bond by transition metal chemistry. Angew Chem Int Ed Engl. 2002 Jun 17; 41(12):2107-10.
Nicolaou KC, Roecker AJ, Follmann M, Baati R. PMID: 19746611.
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3 Fields:
Translation:
Cells
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Model studies towards azadirachtin: part 1. Construction of the crowded C8-C14 bond by radical chemistry. Angew Chem Int Ed Engl. 2002 Jun 17; 41(12):2103-6.
Nicolaou KC, Follmann M, Roecker AJ, Hunt KW. PMID: 19746610.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Stereocontrolled synthesis of the quinaldic acid macrocyclic system of thiostrepton. Angew Chem Int Ed Engl. 2002 Jun 03; 41(11):1937-40.
Nicolaou KC, Safina BS, Funke C, Zak M, Zécri FJ. PMID: 19750639.
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PubMed Mentions:
4 Fields:
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A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton. Angew Chem Int Ed Engl. 2002 Jun 03; 41(11):1941-5.
Nicolaou KC, Nevalainen M, Safina BS, Zak M, Bulat S. PMID: 19750640.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Novel chemistry of alpha-tosyloxy ketones: applications to the solution- and solid-phase synthesis of privileged heterocycle and enediyne libraries. J Am Chem Soc. 2002 May 22; 124(20):5718-28.
Nicolaou KC, Montagnon T, Ulven T, Baran PS, Zhong YL, Sarabia F. PMID: 12010045.
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4 Fields:
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The Diels--Alder reaction in total synthesis. Angew Chem Int Ed Engl. 2002 May 17; 41(10):1668-98.
Nicolaou KC, Snyder SA, Montagnon T, Vassilikogiannakis G. PMID: 19750686.
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PubMed Mentions:
251 Fields:
Translation:
Cells
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HIO3 and I2O5: mild and selective alternative reagents to IBX for the dehydrogenation of aldehydes and ketones. Angew Chem Int Ed Engl. 2002 Apr 15; 41(8):1386-9.
Nicolaou KC, Montagnon T, Baran PS. PMID: 19750773.
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5 Fields:
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Modulation of the reactivity profile of IBX by ligand complexation: ambient temperature dehydrogenation of aldehydes and ketones to alpha,beta-unsaturated carbonyl compounds. Angew Chem Int Ed Engl. 2002 Mar 15; 41(6):993-6.
Nicolaou KC, Montagnon T, Baran PS. PMID: 12491291.
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23 Fields:
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Oxidation of silyl enol ethers by using IBX and IBX.N-oxide complexes: a mild and selective reaction for the synthesis of enones. Angew Chem Int Ed Engl. 2002 Mar 15; 41(6):996-1000.
Nicolaou KC, Gray DL, Montagnon T, Harrison ST. PMID: 12491292.
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31 Fields:
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Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 2. Model studies for the construction of key structural elements and first-generation strategy. J Am Chem Soc. 2002 Mar 13; 124(10):2190-201.
Nicolaou KC, Baran PS, Zhong YL, Fong KC, Choi HS. PMID: 11878973.
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PubMed Mentions:
5 Fields:
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Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 3. Completion and synthesis of advanced analogues. J Am Chem Soc. 2002 Mar 13; 124(10):2202-11.
Nicolaou KC, Zhong YL, Baran PS, Jung J, Choi HS, Yoon WH. PMID: 11878974.
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3 Fields:
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Iodine(V) reagents in organic synthesis. Part 1. Synthesis of polycyclic heterocycles via Dess-Martin periodinane-mediated cascade cyclization: generality, scope, and mechanism of the reaction. J Am Chem Soc. 2002 Mar 13; 124(10):2212-20.
Nicolaou KC, Baran PS, Zhong YL, Sugita K. PMID: 11878975.
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PubMed Mentions:
10 Fields:
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Iodine(V) reagents in organic synthesis. Part 2. Access to complex molecular architectures via Dess-Martin periodinane-generated o-imidoquinones. J Am Chem Soc. 2002 Mar 13; 124(10):2221-32.
Nicolaou KC, Sugita K, Baran PS, Zhong YL. PMID: 11878976.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 1. Racemic and asymmetric synthesis of bicyclo[4.3.1] key building blocks. J Am Chem Soc. 2002 Mar 13; 124(10):2183-9.
Nicolaou KC, Jung J, Yoon WH, Fong KC, Choi HS, He Y, Zhong YL, Baran PS. PMID: 11878972.
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3 Fields:
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Iodine(V) reagents in organic synthesis. Part 3. New routes to heterocyclic compounds via o-iodoxybenzoic acid-mediated cyclizations: generality, scope, and mechanism. J Am Chem Soc. 2002 Mar 13; 124(10):2233-44.
Nicolaou KC, Baran PS, Zhong YL, Barluenga S, Hunt KW, Kranich R, Vega JA. PMID: 11878977.
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31 Fields:
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Iodine(V) reagents in organic synthesis. Part 4. o-Iodoxybenzoic acid as a chemospecific tool for single electron transfer-based oxidation processes. J Am Chem Soc. 2002 Mar 13; 124(10):2245-58.
Nicolaou KC, Montagnon T, Baran PS, Zhong YL. PMID: 11878978.
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PubMed Mentions:
43 Fields:
Translation:
Cells
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A novel regio- and stereoselective synthesis of sulfamidates from 1,2-diols using Burgess and related reagents: a facile entry into beta-amino alcohols. Angew Chem Int Ed Engl. 2002 Mar 01; 41(5):834-8.
Nicolaou KC, Huang X, Snyder SA, Bheema Rao P, Bella M, Reddy MV. PMID: 12491352.
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4 Fields:
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Diversity-oriented organic synthesis and proteomics. New frontiers for chemistry & biology. Chem Biol. 2002 Jan; 9(1):1-2.
Schreiber SL, Nicolaou KC, Davies K. PMID: 11841933.
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7 Fields:
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Total synthesis of colombiasin A and determination of its absolute configuration. Chemistry. 2001 Dec 17; 7(24):5359-71.
Nicolaou KC, Vassilikogiannakis G, Mägerlein W, Kranich R. PMID: 11822436.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Construction of the Complete Aromatic Core of Diazonamide A by a Novel Hetero Pinacol Macrocyclization Cascade Reaction We thank Drs. D. H. Huang and G. Suizdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), American Biosciences, a predoctoral fellowship from the National Science Foundation (S.A.S.), a postdoctoral fellowship from the Association pour la Recherche sur le Cancer (N.G.), and grants from Abbott, Amgen, Array Biopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Dec 17; 40(24):4705-4709.
Nicolaou KC, Huang X, Giuseppone N, Bheema Rao P, Bella M, Reddy MV, Snyder SA. PMID: 12404390.
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6 Fields:
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cis-3,4-Dichlorocyclobutene as a Versatile Synthon in Organic Synthesis. Rapid Entry into Complex Polycyclic Systems with Remarkably Stereospecific Reactions We thank Drs. D. H. Huang and G. Siuzdak for their assistance with NMR spectroscopy and mass spectrometry, respectively. This work was financially supported by the National Institutes of Health (USA) and The Skaggs Institute for Chemical Biology, a postdoctoral fellowship from the Skaggs Institute for Research (to V.G.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Dec 03; 40(23):4441-4445.
Nicolaou KC, Vega JA, Vassilikogiannakis G. PMID: 12404439.
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4 Fields:
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"Biomimetic" Cascade Reactions in Organic Synthesis: Construction of 4-Oxatricyclo[4.3.1.0]decan-2-one Systems and Total Synthesis of 1-O-Methylforbesione via Tandem Claisen Rearrangement/Diels-Alder Reactions. Angew Chem Int Ed Engl. 2001 Nov 19; 40(22):4264-4268.
Nicolaou KC, Li J. PMID: 29712093.
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12 Fields:
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Synthesis of the ABCD Ring System of Azaspiracid. Angew Chem Int Ed Engl. 2001 Nov 05; 40(21):4068-4071.
Nicolaou KC, Qian W, Bernal F, Uesaka N, Pihko PM, Hinrichs J. PMID: 29712267.
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6 Fields:
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Synthesis of the ABCD Ring System of Azaspiracid We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, a predoctoral fellowship from Bristol-Myers Squibb (to F.B.), postdoctoral fellowships from The Skaggs Institute for Research (to W.Q.), the Academy of Finland, the Ella and Georg Ehrnrooth Foundation and the Tauno Tönning Foundation (all to P.M.P.), and Bayer AG (to J.H.), as well as grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Nov 05; 40(21):4068-4071.
Nicolaou KC, Qian W, Bernal F, Uesaka N, Pihko PM, Hinrichs J. PMID: 12404495.
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PubMed Mentions:
2 Fields:
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Total Synthesis of Apoptolidin: Part 1. Retrosynthetic Analysis and Construction of Building Blocks. Angew Chem Int Ed Engl. 2001 Oct 15; 40(20):3849-3854.
Nicolaou KC, Li Y, Fylaktakidou KC, Mitchell HJ, Wei HX, Weyershausen B. PMID: 29712121.
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PubMed Mentions:
1 Fields:
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Total Synthesis of Apoptolidin: Part 2. Coupling of Key Building Blocks and Completion of the Synthesis. Angew Chem Int Ed Engl. 2001 Oct 15; 40(20):3854-3857.
Nicolaou KC, Li Y, Fylaktakidou KC, Mitchell HJ, Sugita K. PMID: 29712136.
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2 Fields:
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Total Synthesis of Apoptolidin: Part 1. Retrosynthetic Analysis and Construction of Building Blocks We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, American Biosciences, a pre-doctoral fellowship from Boehringer Ingelheim (Y.L.), a postdoctoral fellowship the George Hewitt Foundation (K.C.F.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Oct 15; 40(20):3849-3854.
Nicolaou KC, Li Y, Fylaktakidou KC, Mitchell HJ, Wei HX, Weyershausen B. PMID: 11668553.
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PubMed Mentions:
3 Fields:
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Total Synthesis of Apoptolidin: Part 2. Coupling of Key Building Blocks and Completion of the Synthesis We thank Dr. C. Khosla and Dr. Y. Hayakawa for generous gifts of apoptolidin, and Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, American Biosciences, a predoctoral fellowship from Boehringer Ingelheim (to Y.L.), a postdoctoral fellowship the George Hewitt Foundation (to K.C.F.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Oct 15; 40(20):3854-3857.
Nicolaou KC, Li Y, Fylaktakidou KC, Mitchell HJ, Sugita K. PMID: 11668554.
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Total Synthesis of Hamigerans: Part 2. Implementation of the Intramolecular Diels-Alder Trapping of Photochemically Generated Hydroxy-o-quinodimethanes; Strategy and Completion of the Synthesis This work was financially supported by the National Institutes of Health (USA) and The Skaggs Institute for Chemical Biology, and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Oct 01; 40(19):3679-3683.
Nicolaou KC, Gray D, Tae J. PMID: 11592220.
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PubMed Mentions:
12 Fields:
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Total Synthesis of Hamigerans: Part 1. Development of Synthetic Technology for the Construction of Benzannulated Polycyclic Systems by the Intramolecular Trapping of Photogenerated Hydroxy-o-quinodimethanes and Synthesis of Key Building Blocks This work was financially supported by the National Institutes of Health (USA) and The Skaggs Institute for Chemical Biology, and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Oct 01; 40(19):3675-3678.
Nicolaou KC, Gray D, Tae J. PMID: 11592219.
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16 Fields:
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Antitumor efficacy of 26-fluoroepothilone B against human prostate cancer xenografts. Cancer Chemother Pharmacol. 2001 Oct; 48(4):319-26.
Newman RA, Yang J, Raymond M, Finlay V, Cabral F, Vourloumis D, Stephens LC, Troncoso P, Wu X, Logothetis CJ, Nicolaou KC, Navone NM. PMID: 11710633.
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7 Fields:
Translation:
HumansAnimalsCells
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Optimization and mechanistic studies of psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA). Chemistry. 2001 Oct 01; 7(19):4296-310.
Nicolaou KC, Hughes R, Pfefferkorn JA, Barluenga S. PMID: 11686610.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA). Chemistry. 2001 Oct 01; 7(19):4280-95.
Nicolaou KC, Hughes R, Pfefferkorn JA, Barluenga S, Roecker AJ. PMID: 11686609.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues. J Am Chem Soc. 2001 Sep 26; 123(38):9313-23.
Nicolaou KC, Namoto K, Ritzén A, Ulven T, Shoji M, Li J, D'Amico G, Liotta D, French CT, Wartmann M, Altmann KH, Giannakakou P. PMID: 11562214.
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11 Fields:
Translation:
HumansCells
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Recent developments in the chemistry, biology and medicine of the epothilones. Chem Commun (Camb). 2001 Sep 07; (17):1523-35.
Nicolaou KC, Ritzén A, Namoto K. PMID: 12240368.
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17 Fields:
Translation:
HumansAnimalsCells
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Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: target-accelerated combinatorial synthesis. Chemistry. 2001 Sep 03; 7(17):3824-43.
Nicolaou KC, Hughes R, Cho SY, Winssinger N, Labischinski H, Endermann R. PMID: 11575783.
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PubMed Mentions:
21 Fields:
Translation:
Cells
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Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria. Chemistry. 2001 Sep 03; 7(17):3798-823.
Nicolaou KC, Cho SY, Hughes R, Winssinger N, Smethurst C, Labischinski H, Endermann R. PMID: 11575782.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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Total Synthesis of Colombiasin A This work was financially supported by the National Institutes of Health (USA) and The Skaggs Institute for Chemical Biology, postdoctoral fellowships from Bayer AG (to R.K. and W.M.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Jul 02; 40(13):2482-2486.
Nicolaou KC, Vassilikogiannakis G, Mägerlein W, Kranich R. PMID: 11443672.
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Total Synthesis of Colombiasin A. Angew Chem Int Ed Engl. 2001 Jul 02; 40(13):2482-2486.
Nicolaou KC, Vassilikogiannakis G, Mägerlein W, Kranich R. PMID: 29712275.
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13 Fields:
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Rapid Access to Complex Molecular Architectures via o-Azaquinones. Angew Chem Int Ed Engl. 2001 Jun 01; 40(11):2145-2149.
Nicolaou KC, Zhong YL, Baran PS, Sugita K. PMID: 29712189.
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PubMed Mentions: Fields:
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Rapid Access to Complex Molecular Architectures via o-Azaquinones We thank Dr. D. H. Huang, G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. This work was supported financially by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.S.B), and grants from ArrayBiopharma, Pfizer, Glaxo, Merck, Schering Plough, Hoffmann-La Roche, Boehringer Ingelheim, DuPont, and Abbott Laboratories. Angew Chem Int Ed Engl. 2001 Jun 01; 40(11):2145-2149.
Nicolaou KC, Zhong YL, Baran PS, Sugita K. PMID: 11433472.
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PubMed Mentions:
1 Fields:
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Discovery of novel antibacterial agents active against methicillin-resistant Staphylococcus aureus from combinatorial benzopyran libraries. Chembiochem. 2001 Jun 01; 2(6):460-5.
Nicolaou KC, Roecker AJ, Barluenga S, Pfefferkorn JA, Cao GQ. PMID: 11828478.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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New Synthetic Technology for the Construction of N-Containing Quinones and Derivatives Thereof: Total Synthesis of Epoxyquinomycin B We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 May 04; 40(9):1573.
Nicolaou KC, Sugita K, Baran PS, Zhong YL. PMID: 11353465.
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PubMed Mentions: Fields:
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Synthesis of the FGHI Ring System of Azaspiracid We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from Bristol-Myers Squibb (F.B.), postdoctoral fellowships from the Academy of Finland, the Ella and Georg Ehrnrooth Foundation, and the Tauno Tönning Foundation (all to P.M.P.), ArrayBiopharma (N.Z.), and Bayer AG (N.D.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 May 04; 40(9):1573.
Nicolaou KC, Pihko PM, Diedrichs N, Zou N, Bernal F. PMID: 11353466.
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2 Fields:
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Adventures in Carbohydrate Chemistry: New Synthetic Technologies, Chemical Synthesis, Molecular Design, and Chemical Biology A list of abbreviations can be found at the end of this article. Telemachos Charalambous was an inspiring teacher at the Pancyprian Gymnasium, Nicosia, Cyprus. Angew Chem Int Ed Engl. 2001 May 04; 40(9):1576-1624.
Nicolaou KC, Mitchell HJ. PMID: 11353467.
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40 Fields:
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Behind enemy lines. Sci Am. 2001 May; 284(5):54-61.
Nicolaou KC, Boddy CN. PMID: 11341163.
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2 Fields:
Translation:
Cells
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Selective oxidation at carbon adjacent to aromatic systems with IBX. J Am Chem Soc. 2001 Apr 04; 123(13):3183-5.
Nicolaou KC, Baran PS, Zhong YL. PMID: 11457049.
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19 Fields:
Translation:
Cells
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Synthesis of the FGHI Ring System of Azaspiracid We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from Bristol-Myers Squibb (F.B.), postdoctoral fellowships from the Academy of Finland, the Ella and Georg Ehrnrooth Foundation, and the Tauno Tönning Foundation (all to P.M.P.), ArrayBiopharma (N.Z.), and Bayer AG (N.D.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Apr 01; 40(7):1262-1265.
Nicolaou KC, Pihko PM, Diedrichs N, Zou N, Bernal F. PMID: 11301444.
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6 Fields:
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Does CIP Nomenclature Adequately Handle Molecules with Multiple Stereoelements? A Case Study of Vancomycin and Cognates We would like to thank Professor Dieter Hellwinkel for pointing out to us the stereochemical discrepancies in our review6 and elsewhere in the literature, and Kurt Mislow for stimulating and useful discussions. Angew Chem Int Ed Engl. 2001 Feb 16; 40(4):701-704.
Nicolaou KC, Boddy CN, Siegel JS. PMID: 11241596.
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1 Fields:
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Total Synthesis of Hybocarpone We thank Dr. D. H. Huang, Dr. G. Siuzdak and Dr. I. Ioannou for NMR spectroscopic, mass spectrometric and computational assistance, respectively. Financial support for this work was provided by the Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, CaPCURE, and Schering Plough. Angew Chem Int Ed Engl. 2001 Feb 16; 40(4):761-763.
Nicolaou KC, Gray D. PMID: 11241615.
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9 Fields:
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Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones. Chembiochem. 2001 Jan 08; 2(1):69-75.
Nicolaou KC, Namoto K, Li J, Ritzén A, Ulven T, Shoji M, Zaharevitz D, Gussio R, Sackett DL, Ward RD, Hensler A, Fojo T, Giannakakou P. PMID: 11828429.
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4 Fields:
Translation:
HumansCells
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New Synthetic Technology for the Construction of N-Containing Quinones and Derivatives Thereof: Total Synthesis of Epoxyquinomycin B We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Jan 05; 40(1):207-210.
Nicolaou KC, Sugita K, Baran PS, Zhong YL. PMID: 11169714.
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Mechanistic Studies of Periodinane-Mediated Reactions of Anilides and Related Systems Professors M. G. Finn, A. Eschenmoser, and M. E. Newcomb are gratefully acknowledged for valuable discussions and suggestions. We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. We would also like to thank Dr. G. Vasilikogiannakis for helpful discussions and an anonymous referee for critical suggestions. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), postdoctoral fellowships from ArrayBiopharma (N.Z.) and Bayer AG (R.K.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Jan 05; 40(1):202-206.
Nicolaou KC, Baran PS, Kranich R, Zhong YL, Sugita K, Zou N. PMID: 11169713.
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New Synthetic Technology for the Construction of N-Containing Quinones and Derivatives Thereof: Total Synthesis of Epoxyquinomycin B. Angew Chem Int Ed Engl. 2001 Jan 05; 40(1):207-210.
Nicolaou KC, Sugita K, Baran PS, Zhong YL. PMID: 29711950.
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PubMed Mentions:
5 Fields:
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Mechanistic Studies of Periodinane-Mediated Reactions of Anilides and Related Systems. Angew Chem Int Ed Engl. 2001 Jan 05; 40(1):202-206.
Nicolaou KC, Baran PS, Kranich R, Zhong YL, Sugita K, Zou N. PMID: 29711956.
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PubMed Mentions:
5 Fields:
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Solid phase synthesis of complex natural products and libraries thereof. Biopolymers. 2001; 60(3):171-93.
Nicolaou KC, Pfefferkorn JA. PMID: 11774224.
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2 Fields:
Translation:
Cells
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Combinatorial synthesis of novel and potent inhibitors of NADH:ubiquinone oxidoreductase. Chem Biol. 2000 Dec; 7(12):979-92.
Nicolaou K, Pfefferkorn J, Schuler F, Roecker A, Cao G, Casida J. PMID: 11137820.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria. Angew Chem Int Ed Engl. 2000 Nov 03; 39(21):3823-3828.
Nicolaou KC, Hughes R, Cho SY, Winssinger N, Smethurst C, Labischinski H, Endermann R. PMID: 29711708.
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22 Fields:
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Total synthesis of everninomicin 13,384-1--Part 4: explorations of methodology; stereocontrolled synthesis of 1,1'-disaccharides, 1,2-seleno migrations in carbohydrates, and solution- and solid-phase synthesis of 2-deoxy glycosides and orthoesters. Chemistry. 2000 Sep 01; 6(17):3166-85.
Nicolaou KC, Fylaktakidou KC, Mitchell HJ, van Delft FL, Rodríguez RM, Conley SR, Jin Z. PMID: 11002995.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Total synthesis of everninomicin 13,384-1--Part 3: synthesis of the DE fragment and completion of the total synthesis. Chemistry. 2000 Sep 01; 6(17):3149-65.
Nicolaou KC, Mitchell HJ, Rodríguez RM, Fylaktakidou KC, Suzuki H, Conley SR. PMID: 11002994.
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6 Fields:
Translation:
Cells
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Total synthesis of everninomicin 13,384-1--Part 1: retrosynthetic analysis and synthesis of the A1B(A)C fragment. Chemistry. 2000 Sep 01; 6(17):3095-115.
Nicolaou KC, Rodríguez RM, Mitchell HJ, Suzuki H, Fylaktakidou KC, Baudoin O, van Delft FL. PMID: 11002992.
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9 Fields:
Translation:
Cells
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Total synthesis of everninomicin 13,384-1--Part 2: synthesis of the FGHA2 fragment. Chemistry. 2000 Sep 01; 6(17):3116-48.
Nicolaou KC, Mitchell HJ, Fylaktakidou KC, Rodríguez RM, Suzuki H. PMID: 11002993.
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3 Fields:
Translation:
Cells
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Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues. Chemistry. 2000 Aug 04; 6(15):2783-800.
Nicolaou KC, Hepworth D, King NP, Finlay MR, Scarpelli R, Pereira MM, Bollbuck B, Bigot A, Werschkun B, Winssinger N. PMID: 10985727.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Chemical synthesis and biological properties of pyridine epothilones. Chem Biol. 2000 Aug; 7(8):593-9.
Nicolaou KC, Scarpelli R, Bollbuck B, Werschkun B, Pereira MM, Wartmann M, Altmann KH, Zaharevitz D, Gussio R, Giannakakou P. PMID: 11048950.
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16 Fields:
Translation:
HumansCells
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A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. Proc Natl Acad Sci U S A. 2000 Mar 14; 97(6):2904-9.
Giannakakou P, Gussio R, Nogales E, Downing KH, Zaharevitz D, Bollbuck B, Poy G, Sackett D, Nicolaou KC, Fojo T. PMID: 10688884; PMCID: PMC16028.
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PubMed Mentions:
100 Fields:
Translation:
HumansCells
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Solid-phase combinatorial synthesis using MicroKan reactors, Rf tagging, and directed sorting. Biotechnol Bioeng. 2000; 71(1):44-50.
Xiao XY, Li R, Zhuang H, Ewing B, Karunaratne K, Lillig J, Brown R, Nicolaou KC. PMID: 10629535.
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PubMed Mentions:
5 Fields:
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New synthetic technology for the synthesis of hindered alpha-diazoketones via acyl mesylates. Org Lett. 1999 Sep 23; 1(6):883-6.
Nicolaou KC, Baran PS, Zhong YL, Choi HS, Fong KC, He Y, Yoon WH. PMID: 10823217.
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PubMed Mentions:
4 Fields:
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A facile method for the solution and solid-phase synthesis of substituted [3.3.1] bicycles. Org Lett. 1999 Sep 09; 1(5):807-10.
Nicolaou KC, Pfefferkorn JA, Cao GQ, Kim S, Kessabi J. PMID: 10823208.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Total synthesis and chemical biology of the sarcodictyins. Chem Pharm Bull (Tokyo). 1999 Sep; 47(9):1199-213.
Nicolaou KC, Pfefferkorn J, Xu J, Winssinger N, Ohshima T, Kim S, Hosokawa S, Vourloumis D, van Delft F, Li T. PMID: 10517002.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Inhibition of protein kinases by balanol: specificity within the serine/threonine protein kinase subfamily. Mol Pharmacol. 1999 Aug; 56(2):370-6.
Setyawan J, Koide K, Diller TC, Bunnage ME, Taylor SS, Nicolaou KC, Brunton LL. PMID: 10419556.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Novel strategies to construct the gamma-hydroxy lactone moiety of the CP molecules. Synthesis of the CP-225,917 core skeleton. Org Lett. 1999 Jul 15; 1(1):63-6.
Nicolaou KC, He Y, Fong KC, Yoon WH, Choi HS, Zhong YL, Baran PS. PMID: 10822534.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Total Synthesis of the CP Molecules CP-225,917 and CP-263,114- Part 2: Evolution of the Final Strategy. Angew Chem Int Ed Engl. 1999 Jun 01; 38(11):1676-1678.
Nicolaou KC, Baran PS, Zhong YL, Fong KC, He Y, Yoon WH, Choi HS. PMID: 29710974.
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PubMed Mentions:
4 Fields:
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Total Synthesis of the CP Molecules CP-263,114 and CP-225,917- Part 1: Synthesis of Key Intermediates and Intelligence Gathering. Angew Chem Int Ed Engl. 1999 Jun 01; 38(11):1669-1675.
Nicolaou KC, Baran PS, Zhong YL, Choi HS, Yoon WH, He Y, Fong KC. PMID: 29710978.
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PubMed Mentions:
8 Fields:
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Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy. Bioorg Med Chem. 1999 May; 7(5):665-97.
Nicolaou KC, King NP, Finlay MR, He Y, Roschangar F, Vourloumis D, Vallberg H, Sarabia F, Ninkovic S, Hepworth D. PMID: 10400321.
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PubMed Mentions:
9 Fields:
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The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. Biochemistry. 1999 Apr 27; 38(17):5490-8.
Hamel E, Sackett DL, Vourloumis D, Nicolaou KC. PMID: 10220336.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry. 1999 Feb 23; 38(8):2367-76.
Narayana N, Diller TC, Koide K, Bunnage ME, Nicolaou KC, Brunton LL, Xuong NH, Ten Eyck LF, Taylor SS. PMID: 10029530.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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A Novel Route to the Fused Maleic Anhydride Moiety of CP Molecules. Angew Chem Int Ed Engl. 1999 Feb 15; 38(4):549-552.
Nicolaou KC, Baran PS, Jautelat R, He Y, Fong KC, Choi HS, Yoon WH, Zhong YL. PMID: 29711784.
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PubMed Mentions:
1 Fields:
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The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products. Angew Chem Int Ed Engl. 1999 Feb 01; 38(3):270-301.
Papageorgiou VP, Assimopoulou AN, Couladouros EA, Hepworth D, Nicolaou KC. PMID: 29711637.
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PubMed Mentions:
128 Fields:
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Total Synthesis of Vancomycin Aglycon-Part 1: Synthesis of Amino Acids 4-7 and Construction of the AB-COD Ring Skeleton. Angew Chem Int Ed Engl. 1998 Oct 16; 37(19):2708-2714.
Nicolaou KC, Natarajan S, Li H, Jain NF, Hughes R, Solomon ME, Ramanjulu JM, Boddy CNC, Takayanagi M. PMID: 29711605.
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PubMed Mentions:
21 Fields:
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Total Synthesis of Vancomycin Aglycon-Part 2: Synthesis of Amino Acids 1-3 and Construction of the AB-COD-DOE Ring Skeleton. Angew Chem Int Ed Engl. 1998 Oct 16; 37(19):2714-2716.
Nicolaou KC, Jain NF, Natarajan S, Hughes R, Solomon ME, Li H, Ramanjulu JM, Takayanagi M, Koumbis AE, Bando T. PMID: 29711613.
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PubMed Mentions:
14 Fields:
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Total Synthesis of Vancomycin Aglycon-Part 3: Final Stages. Angew Chem Int Ed Engl. 1998 Oct 16; 37(19):2717-2719.
Nicolaou KC, Takayanagi M, Jain NF, Natarajan S, Koumbis AE, Bando T, Ramanjulu JM. PMID: 29711623.
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PubMed Mentions:
18 Fields:
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Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone. Angew Chem Int Ed Engl. 1998 Oct 02; 37(18):2534-2537.
Nicolaou KC, Winssinger N, Pastor J, Murphy F. PMID: 29711345.
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PubMed Mentions:
3 Fields:
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Chemical Biology of Epothilones. Angew Chem Int Ed Engl. 1998 Aug 17; 37(15):2014-2045.
Nicolaou KC, Roschangar F, Vourloumis D. PMID: 29711063.
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PubMed Mentions:
26 Fields:
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Design, synthesis and biological evaluation of nonpeptide integrin antagonists. Bioorg Med Chem. 1998 Aug; 6(8):1185-208.
Nicolaou KC, Trujillo JI, Jandeleit B, Chibale K, Rosenfeld M, Diefenbach B, Cheresh DA, Goodman SL. PMID: 9784861.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Targeted therapy with a novel enediyene antibiotic calicheamicin theta(I)1 effectively suppresses growth and dissemination of liver metastases in a syngeneic model of murine neuroblastoma. Cancer Res. 1998 Jul 15; 58(14):2925-8.
Lode HN, Reisfeld RA, Handgretinger R, Nicolaou KC, Gaedicke G, Wrasidlo W. PMID: 9679947.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones. Chem Biol. 1998 Jul; 5(7):365-72.
Nicolaou KC, Finlay MR, Ninkovic S, King NP, He Y, Li T, Sarabia F, Vourloumis D. PMID: 9662505.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Solid-Phase Synthesis of Oligosaccharides: Construction of a Dodecasaccharide. Angew Chem Int Ed Engl. 1998 Jun 19; 37(11):1559-1561.
Nicolaou KC, Watanabe N, Li J, Pastor J, Winssinger N. PMID: 29710918.
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PubMed Mentions:
2 Fields:
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Synthesis and Biological Activity of Sarcodictyins. Angew Chem Int Ed Engl. 1998 Jun 05; 37(10):1418-1421.
Nicolaou KC, Kim S, Pfefferkorn J, Xu J, Ohshima T, Hosokawa S, Vourloumis D, Li T. PMID: 29710898.
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PubMed Mentions:
10 Fields:
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Concise and Efficient Total Syntheses of Alkannin and Shikonin. Angew Chem Int Ed Engl. 1998 Apr 03; 37(6):839-841.
Nicolaou KC, Hepworth D. PMID: 29711400.
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5 Fields:
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Total synthesis of brevetoxin A. Nature. 1998 Mar 19; 392(6673):264-9.
Nicolaou KC, Yang Z, Shi G, Gunzner JL, Agrios KA, Gärtner P. PMID: 9521320.
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17 Fields:
Translation:
Animals
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Synthesis of epothilones A and B in solid and solution phase. Nature. 1997 May 15; 387(6630):268-72.
Nicolaou KC, Winssinger N, Pastor J, Ninkovic S, Sarabia F, He Y, Vourloumis D, Yang Z, Li T, Giannakakou P, Hamel E. PMID: 9153390.
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35 Fields:
Translation:
HumansCells
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The chemical end-ligation of homopyrimidine oligodeoxyribonucleotides within a DNA triple helix. Chem Biol. 1997 Mar; 4(3):209-14.
Li T, Weinstein DS, Nicolaou K. PMID: 9115413.
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5 Fields:
Translation:
Cells
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The oxide anion accelerated retro-diels-alder reaction. Chemistry. 1997 Feb; 3(2):187-92.
Bunnage ME, Nicolaou KC. PMID: 24022946.
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2 Fields:
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Fluorescent taxoids. Chem Biol. 1996 Dec; 3(12):1021-31.
Guy R, Scott Z, Sloboda R, Nicolaou K. PMID: 9000007.
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19 Fields:
Translation:
HumansAnimalsCells
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Taxoids: new weapons against cancer. Sci Am. 1996 Jun; 274(6):94-8.
Nicolaou KC, Guy RK, Potier P. PMID: 8643952.
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10 Fields:
Translation:
HumansAnimalsCells
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The enediyne antibiotics. J Med Chem. 1996 May 24; 39(11):2103-17.
Smith AL, Nicolaou KC. PMID: 8667354.
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47 Fields:
Translation:
HumansAnimalsCells
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Sequence-selective carbohydrate-DNA interaction: dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function. Proc Natl Acad Sci U S A. 1996 Jan 23; 93(2):940-4.
Liu C, Smith BM, Ajito K, Komatsu H, Gomez-Paloma L, Li T, Theodorakis EA, Nicolaou KC, Vogt PK. PMID: 8570664; PMCID: PMC40163.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. Chem Biol. 1995 Sep; 2(9):601-8.
Koide K, Bunnage ME, Gomez Paloma L, Kanter JR, Taylor SS, Brunton LL, Nicolaou KC. PMID: 9383464.
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11 Fields:
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The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels. Chem Biol. 1995 Aug; 2(8):533-41.
Gawley RE, Rein KS, Jeglitsch G, Adams DJ, Theodorakis EA, Tiebes J, Nicolaou KC, Baden DG. PMID: 9383457.
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17 Fields:
Translation:
AnimalsCells
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Design and synthesis of a rapamycin-based high affinity binding FKBP12 ligand. Chem Biol. 1995 Mar; 2(3):157-61.
Chakraborty TK, Weber HP, Nicolaou KC. PMID: 9383417.
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7 Fields:
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In vivo efficacy of novel synthetic enediynes 1. Acta Oncol. 1995; 34(2):157-64.
Wrasidlo W, Hiatt A, Mauch S, Merlock RA, Nicolaou KC. PMID: 7718252.
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AnimalsCells
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Conformation of a water-soluble derivative of taxol in water by 2D-NMR spectroscopy. Chem Biol. 1994 Oct; 1(2):107-12.
Gomez Paloma L, Guy RK, Wrasidlo W, Nicolaou KC. PMID: 9383378.
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15 Fields:
Translation:
Cells
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Synthetic calicheamicin mimics with novel initiation mechanisms: DNA cleavage, cytotoxicity, and apoptosis. Chem Biol. 1994 Sep; 1(1):57-66.
Nicolaou KC, Pitsinos EN, Theodorakis EA, Saimoto H, Wrasidlo W. PMID: 9383371.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Antiproliferative effects of enediynes on AIDS-derived Kaposi's sarcoma cells. Cancer Res. 1994 Aug 15; 54(16):4270-3.
Corbeil J, Richman DD, Wrasidlo W, Nicolaou KC, Looney DJ. PMID: 8044770.
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Translation:
HumansCells
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Chemical self-replication of palindromic duplex DNA. Nature. 1994 May 19; 369(6477):218-21.
Li T, Nicolaou KC. PMID: 8183341.
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33 Fields:
Translation:
Cells
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Total synthesis of taxol. Nature. 1994 Feb 17; 367(6464):630-4.
Nicolaou KC, Yang Z, Liu JJ, Ueno H, Nantermet PG, Guy RK, Claiborne CF, Renaud J, Couladouros EA, Paulvannan K, et al. PMID: 7906395.
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PubMed Mentions:
124 Fields:
Translation:
Cells
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Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A. Proc Natl Acad Sci U S A. 1993 Sep 01; 90(17):8048-52.
Maryanoff BE, Qiu X, Padmanabhan KP, Tulinsky A, Almond HR, Andrade-Gordon P, Greco MN, Kauffman JA, Nicolaou KC, Liu A, et al. PMID: 8367461; PMCID: PMC47285.
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15 Fields:
Translation:
HumansCells
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Design, synthesis and biological activity of protaxols. Nature. 1993 Jul 29; 364(6436):464-6.
Nicolaou KC, Riemer C, Kerr MA, Rideout D, Wrasidlo W. PMID: 8101355.
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15 Fields:
Translation:
HumansAnimalsCells
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Chemistry and biology of natural and designed enediynes. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):5881-8.
Nicolaou KC, Smith AL, Yue EW. PMID: 8327459; PMCID: PMC46830.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Cell-specific regulation of apoptosis by designed enediynes. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3142-6.
Nicolaou KC, Stabila P, Esmaeli-Azad B, Wrasidlo W, Hiatt A. PMID: 8475052; PMCID: PMC46255.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Designed enediynes: a new class of DNA-cleaving molecules with potent and selective anticancer activity. Science. 1992 May 22; 256(5060):1172-8.
Nicolaou KC, Dai WM, Tsay SC, Estevez VA, Wrasidlo W. PMID: 1589797.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Total synthesis of globotriaosylceramide (Gb3) and lysoglobotriaosylceramide (lysoGb3). Carbohydr Res. 1990 Jul 15; 202:177-91.
Nicolaou KC, Caulfield TJ, Katoaka H. PMID: 2224889.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Stereospecific 1,2-migrations in carbohydrates. Stereocontrolled synthesis of .alpha.- and .beta.-2-deoxyglycosides. J Am Chem Soc. 1986 Apr 01; 108(9):2466-7.
Nicolaou KC, Ladduwahetty T, Randall JL, Chucholowski A. PMID: 22175613.
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PubMed Mentions:
10 Fields:
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New synthetic technology for the construction of oxocenes. J Am Chem Soc. 1986 Apr 01; 108(9):2468-9.
Nicolaou KC, Duggan ME, Hwang CK. PMID: 22175614.
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PubMed Mentions:
6 Fields:
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Modulation of leukotriene synthesis and actions by synthetic derivatives of arachidonic acid. Prostaglandins. 1985 May; 29(5):765-71.
Smith JB, Roth DM, Lefer AM, Petasis NA, Nicolaou KC. PMID: 4011927.
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Translation:
Animals
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Selective inhibition of 5-lipoxygenase by 5,6-methanoleukotriene A4, a stable analogue of leukotriene A4. FEBS Lett. 1982 Jun 21; 143(1):13-6.
Koshishara Y, Murota S, Petasis NA, Nicolaou KC. PMID: 6811315.
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PubMed Mentions:
1 Fields:
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AnimalsCells
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Synthesis and biological properties of prostaglandin endoperoxides, thromboxanes and prostacyclins. Angew Chem Int Ed Engl. 1978 May; 17(5):293-312.
Nicolaou KC, Gasic GP, Barnette WE. PMID: 98074.
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2 Fields:
Translation:
Animals
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6,9-thiaprostacyclin. A stable and biologically potent analogue of prostacyclin (PGI2) J Am Chem Soc. 1977 Nov 09; 99(23):7736-8.
Nicolaou KC, Barnette WE, Gasic GP, Magolda RL. PMID: 334822.
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6 Fields:
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Letter: Total synthesis of (plus or minus)-vermiculine. J Am Chem Soc. 1975 Apr 16; 97(8):2287-8.
Corey EJ, Nicolaou KC, Toru T. PMID: 1133413.
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1 Fields:
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Letter: Synthesis of novel macrocyclic lactones in the prostaglandin and polyether antibiotic series. J Am Chem Soc. 1975 Feb 05; 97(3):653-4.
Cory EJ, Nicolaou KC, Melvin LS. PMID: 1133366.
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2 Fields: