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    Kyriacos Nicolaou

    Address9500 Gilman Drive #0358
    CA La Jolla 92093
    Phone858-784-2400
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Nicolaou K, Rhoades D, Wang Y, Bai R, Hamel E, Aujay M, Sandoval J, Gavrilyuk J. 12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents. J Am Chem Soc. 2017 May 31; 139(21):7318-7334. PMID: 28513142.
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      2. Nicolaou K, Liu G, Beabout K, McCurry MD, Shamoo Y. Asymmetric Alkylation of Anthrones, Enantioselective Total Synthesis of (-)- and (+)-Viridicatumtoxins B and Analogues Thereof: Absolute Configuration and Potent Antibacterial Agents. J Am Chem Soc. 2017 Mar 15; 139(10):3736-3746. PMID: 28256128.
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      3. Nicolaou K, Wang Y, Lu M, Mandal D, Pattanayak MR, Yu R, Shah AA, Chen JS, Zhang H, Crawford JJ, Pasunoori L, Poudel YB, Chowdari NS, Pan C, Nazeer A, Gangwar S, Vite G, Pitsinos EN. Streamlined Total Synthesis of Uncialamycin and Its Application to the Synthesis of Designed Analogues for Biological Investigations. J Am Chem Soc. 2016 Jul 6; 138(26):8235-46. PMID: 27266267.
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      4. Nicolaou K, Rhoades D, Lamani M, Pattanayak MR, Kumar SM. Total Synthesis of Thailanstatin A. J Am Chem Soc. 2016 Jun 22; 138(24):7532-5. PMID: 27266914.
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      5. Nicolaou K, Pulukuri KK, Yu R, Rigol S, Heretsch P, Grove CI, Hale CR, ElMarrouni A. Total Synthesis of ?(12) -Prostaglandin J3 : Evolution of Synthetic Strategies to a Streamlined Process. Chemistry. 2016 Jun 13; 22(25):8559-70. PMID: 27187634.
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      6. Nicolaou K, Pulukuri KK, Rigol S, Heretsch P, Yu R, Grove CI, Hale CR, ElMarrouni A, Fetz V, Brönstrup M, Aujay M, Sandoval J, Gavrilyuk J. Synthesis and Biological Investigation of ?(12)-Prostaglandin J3 (?(12)-PGJ3) Analogues and Related Compounds. J Am Chem Soc. 2016 May 25; 138(20):6550-60. PMID: 27171618.
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      7. He Y, Agarwal PK, Kiran IN, Yu R, Cao B, Zou C, Zhou X, Xu H, Xu B, Zhu L, Lan Y, Nicolaou K. Efficient Synthesis of Dimeric Oxazoles, Piperidines and Tetrahydroisoquinolines from N-Substituted 2-Oxazolones. Chemistry. 2016 Jun 1; 22(23):7696-701. PMID: 27113382.
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      8. Nicolaou K, Cai Q, Sun H, Qin B, Zhu S. Total Synthesis of Trioxacarcins DC-45-A1, A, D, C, and C7?-epi-C and Full Structural Assignment of Trioxacarcin C. J Am Chem Soc. 2016 Mar 9; 138(9):3118-24. PMID: 26910506.
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      9. Nicolaou K, Yin J, Mandal D, Erande RD, Klahn P, Jin M, Aujay M, Sandoval J, Gavrilyuk J, Vourloumis D. Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins. J Am Chem Soc. 2016 Feb 10; 138(5):1698-708. PMID: 26829208.
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      10. Nicolaou K, Vourloumis D, Totokotsopoulos S, Papakyriakou A, Karsunky H, Fernando H, Gavrilyuk J, Webb D, Stepan AF. Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs. ChemMedChem. 2016 Jan; 11(1):31-7. PMID: 26585829.
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      11. Nicolaou K, Rhoades D, Wang Y, Totokotsopoulos S, Bai R, Hamel E. Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues. ChemMedChem. 2015 Dec; 10(12):1974-9. PMID: 26447977.
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      12. Nicolaou K, Lu M, Chen P, Shah AA. Practical Synthesis of p- and o-Amino- and Methoxyphenolic Anthraquinones. Angew Chem Int Ed Engl. 2015 Oct 19; 54(43):12687-91. PMID: 26332286.
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      13. Nicolaou K, Lu Z, Li R, Woods JR, Sohn TI. Total Synthesis of Shishijimicin A. J Am Chem Soc. 2015 Jul 15; 137(27):8716-9. PMID: 26133230.
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      14. Nicolaou K, Shah AA, Korman H, Khan T, Shi L, Worawalai W, Theodorakis EA. Total Synthesis and Structural Revision of Antibiotic CJ-16,264. Angew Chem Int Ed Engl. 2015 Aug 3; 54(32):9203-8. PMID: 26096055.
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      15. Nicolaou K, Nilewski C, Hale CR, Ahles CF, Chiu CA, Ebner C, ElMarrouni A, Yang L, Stiles K, Nagrath D. Synthesis and biological evaluation of dimeric furanoid macroheterocycles: discovery of new anticancer agents. J Am Chem Soc. 2015 Apr 15; 137(14):4766-70. PMID: 25827338.
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      16. Nicolaou K, Cai Q, Qin B, Petersen MT, Mikkelsen RJ, Heretsch P. Total Synthesis of Trioxacarcin DC-45-A2. Angew Chem Int Ed Engl. 2015 Mar 2; 54(10):3074-8. PMID: 25583408.
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      17. Nicolaou K, Heretsch P, Nakamura T, Rudo A, Murata M, Konoki K. Synthesis and Biological Evaluation of QRSTUVWXYZA' Domains of Maitotoxin. J Am Chem Soc. 2014 Nov 19; 136(46):16444-51. PMID: 25374117.
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      18. Ferreiro SF, Vilariño N, Louzao MC, Nicolaou K, Frederick MO, Botana LM. In vitro chronic effects on hERG channel caused by the marine biotoxin azaspiracid-2. Toxicon. 2014 Dec; 91:69-75. PMID: 25286396.
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      19. Nicolaou K. The chemistry-biology-medicine continuum and the drug discovery and development process in academia. Chem Biol. 2014 Sep 18; 21(9):1039-45. PMID: 25237851.
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      20. Nicolaou K, Shi L, Lu M, Pattanayak MR, Shah AA, Ioannidou HA, Lamani M. Total synthesis of myceliothermophins c, d, and e. Angew Chem Int Ed Engl. 2014 Oct 6; 53(41):10970-4. PMID: 25163463.
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      21. Nicolaou K, Hale CR, Nilewski C, Ioannidou HA, ElMarrouni A, Nilewski LG, Beabout K, Wang TT, Shamoo Y. Total synthesis of viridicatumtoxin B and analogues thereof: strategy evolution, structural revision, and biological evaluation. J Am Chem Soc. 2014 Aug 27; 136(34):12137-60. PMID: 25317739.
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      22. Nicolaou K, Heretsch P, ElMarrouni A, Hale CR, Pulukuri KK, Kudva AK, Narayan V, Prabhu KS. Total synthesis of d(12) -prostaglandin j3 , a highly potent and selective antileukemic agent. Angew Chem Int Ed Engl. 2014 Sep 22; 53(39):10443-7. PMID: 25098181.
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      23. Nicolaou K. Advancing the drug discovery and development process. Angew Chem Int Ed Engl. 2014 Aug 25; 53(35):9128-40. PMID: 25045053.
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      24. Nicolaou K. Academic-industrial partnerships in drug discovery and development. Angew Chem Int Ed Engl. 2014 May 5; 53(19):0. PMID: 24706618.
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      25. Nicolaou K. Organic synthesis: the art and science of replicating the molecules of living nature and creating others like them in the laboratory. Proc Math Phys Eng Sci. 2014 Mar 8; 470(2163):20130690. PMID: 24611027.
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      26. Cheng C, Liu Y, Balasis ME, Simmons NL, Li J, Song H, Pan L, Qin Y, Nicolaou K, Sebti SM, Li R. Cyclic Marinopyrrole Derivatives as Disruptors of Mcl-1 and Bcl-xL Binding to Bim. Mar Drugs. 2014; 12(3):1335-48. PMID: 24608970.
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      27. Rodríguez LP, Vilariño N, Louzao MC, Dickerson TJ, Nicolaou K, Frederick MO, Botana LM. Microsphere-based immunoassay for the detection of azaspiracids. Anal Biochem. 2014 Feb 15; 447:58-63. PMID: 24215909.
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      28. Ferreiro SF, Vilariño N, Carrera C, Louzao MC, Santamarina G, Cantalapiedra AG, Rodríguez LP, Cifuentes JM, Vieira AC, Nicolaou K, Frederick MO, Botana LM. In vivo arrhythmogenicity of the marine biotoxin azaspiracid-2 in rats. Arch Toxicol. 2014 Feb; 88(2):425-34. PMID: 23934164.
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      29. Mishra OP, Simmons N, Tyagi S, Pietrofesa R, Shuvaev VV, Valiulin RA, Heretsch P, Nicolaou K, Christofidou-Solomidou M. Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorg Med Chem Lett. 2013 Oct 1; 23(19):5325-8. PMID: 23978651.
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      30. Nicolaou K, Valiulin RA. Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents. Org Biomol Chem. 2013 Jul 7; 11(25):4154-63. PMID: 23685867.
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      31. Nicolaou K. The emergence of the structure of the molecule and the art of its synthesis. Angew Chem Int Ed Engl. 2013 Jan 2; 52(1):131-46. PMID: 23203813.
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      32. Nicolaou K. How thiostrepton was made in the laboratory. Angew Chem Int Ed Engl. 2012 Dec 7; 51(50):12414-36. PMID: 23208736.
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      33. Nicolaou K, Lu M, Totokotsopoulos S, Heretsch P, Giguère D, Sun YP, Sarlah D, Nguyen TH, Wolf IC, Smee DF, Day CW, Bopp S, Winzeler EA. Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematocin and discovery of new antiviral and antimalarial agents. J Am Chem Soc. 2012 Oct 17; 134(41):17320-32. PMID: 22978674.
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      34. Yin S, Kaluz S, Devi NS, Jabbar AA, de Noronha RG, Mun J, Zhang Z, Boreddy PR, Wang W, Wang Z, Abbruscato T, Chen Z, Olson JJ, Zhang R, Goodman MM, Nicolaou K, Van Meir EG. Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1a interaction with cofactors p300/CBP. Clin Cancer Res. 2012 Dec 15; 18(24):6623-33. PMID: 22923450.
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      35. Bian M, Wang Z, Xiong X, Sun Y, Matera C, Nicolaou K, Li A. Total syntheses of anominine and tubingensin A. J Am Chem Soc. 2012 May 16; 134(19):8078-81. PMID: 22537293.
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      36. Koppaka V, Thompson DC, Chen Y, Ellermann M, Nicolaou K, Juvonen RO, Petersen D, Deitrich RA, Hurley TD, Vasiliou V. Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application. Pharmacol Rev. 2012 Jul; 64(3):520-39. PMID: 22544865.
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      37. Nicolaou K, Valiulin RA, Pokorski JK, Chang V, Chen JS. Bio-inspired synthesis and biological evaluation of a colchicine-related compound library. Bioorg Med Chem Lett. 2012 Jun 1; 22(11):3776-80. PMID: 22542017.
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      38. Nicolaou K, Hale CR, Ebner C, Nilewski C, Ahles CF, Rhoades D. Synthesis of macroheterocycles through intramolecular oxidative coupling of furanoid ß-ketoesters. Angew Chem Int Ed Engl. 2012 May 7; 51(19):4726-30. PMID: 22489095.
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      39. Nicolaou K, Giguère D, Totokotsopoulos S, Sun YP. A practical sulfenylation of 2,5-diketopiperazines. Angew Chem Int Ed Engl. 2012 Jan 16; 51(3):728-32. PMID: 22162254.
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      40. Nicolaou K, Ellery SP, Rivas F, Saye K, Rogers E, Workinger TJ, Schallenberger M, Tawatao R, Montero A, Hessell A, Romesberg F, Carson D, Burton D. Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues. Bioorg Med Chem. 2011 Sep 15; 19(18):5648-69. PMID: 21840722.
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      41. Tan C, de Noronha RG, Devi NS, Jabbar AA, Kaluz S, Liu Y, Mooring SR, Nicolaou K, Wang B, Van Meir EG. Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors. Bioorg Med Chem Lett. 2011 Sep 15; 21(18):5528-32. PMID: 21831638.
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      42. Nicolaou K, Totokotsopoulos S, Giguère D, Sun YP, Sarlah D. Total synthesis of epicoccin G. J Am Chem Soc. 2011 Jun 1; 133(21):8150-3. PMID: 21548595.
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      43. Nicolaou K, Simmons NL, Ying Y, Heretsch PM, Chen JS. Enantioselective dichlorination of allylic alcohols. J Am Chem Soc. 2011 Jun 1; 133(21):8134-7. PMID: 21542622.
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      44. Nicolaou K, Simmons NL, Chen JS, Haste NM, Nizet V. Total synthesis and biological evaluation of marinopyrrole A and analogues. Tetrahedron Lett. 2011 Apr 27; 52(17):2041-2043. PMID: 21499535.
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      45. Nicolaou K, Aversa RJ. Maitotoxin: An Inspiration for Synthesis. Isr J Chem. 2011 Apr; 51(3-4):359-377. PMID: 21709816.
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      46. Saielli G, Nicolaou K, Ortiz A, Zhang H, Bagno A. Addressing the stereochemistry of complex organic molecules by density functional theory-NMR: vannusal B in retrospective. J Am Chem Soc. 2011 Apr 20; 133(15):6072-7. PMID: 21438587.
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      47. Wenzel M, Patra M, Albrecht D, Chen DY, Nicolaou K, Metzler-Nolte N, Bandow JE. Proteomic signature of fatty acid biosynthesis inhibition available for in vivo mechanism-of-action studies. Antimicrob Agents Chemother. 2011 Jun; 55(6):2590-6. PMID: 21383089.
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      48. Nicolaou K, Seo JH, Nakamura T, Aversa RJ. Synthesis of the C'D'E'F' domain of maitotoxin. J Am Chem Soc. 2011 Jan 19; 133(2):214-9. PMID: 21166429.
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      49. Nicolaou K, Baker TM, Nakamura T. Synthesis of the WXYZA' domain of maitotoxin. J Am Chem Soc. 2011 Jan 19; 133(2):220-6. PMID: 21166430.
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      50. Nicolaou K, Wang J, Tang Y, Botta L. Total synthesis of sporolide B and 9-epi-sporolide B. J Am Chem Soc. 2010 Aug 18; 132(32):11350-63. PMID: 20698702.
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      51. Nicolaou K, Gelin CF, Seo JH, Huang Z, Umezawa T. Synthesis of the QRSTU domain of maitotoxin and its 85-epi- and 86-epi-diastereoisomers. J Am Chem Soc. 2010 Jul 21; 132(28):9900-7. PMID: 20666400.
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      52. Nicolaou K, Sanchini S, Wu TR, Sarlah D. Total synthesis and structural revision of biyouyanagin B. Chemistry. 2010 Jul 12; 16(26):7678-82. PMID: 20572192.
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      53. Nicolaou K, Kang Q, Ng SY, Chen DY. Total synthesis of englerin A. J Am Chem Soc. 2010 Jun 16; 132(23):8219-22. PMID: 20496885.
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      54. Nicolaou K, Kang Q, Wu TR, Lim CS, Chen DY. Total synthesis and biological evaluation of the resveratrol-derived polyphenol natural products hopeanol and hopeahainol A. J Am Chem Soc. 2010 Jun 2; 132(21):7540-8. PMID: 20462209.
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      55. Nicolaou K, Ortiz A, Zhang H, Guella G. Total synthesis and structural revision of vannusals A and B: synthesis of the true structures of vannusals A and B. J Am Chem Soc. 2010 May 26; 132(20):7153-76. PMID: 20443558.
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      56. Nicolaou K, Ortiz A, Zhang H, Dagneau P, Lanver A, Jennings MP, Arseniyadis S, Faraoni R, Lizos DE. Total synthesis and structural revision of vannusals A and B: synthesis of the originally assigned structure of vannusal B. J Am Chem Soc. 2010 May 26; 132(20):7138-52. PMID: 20443561.
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      57. Nicolaou K, Aversa RJ, Jin J, Rivas F. Synthesis of the ABCDEFG ring system of maitotoxin. J Am Chem Soc. 2010 May 19; 132(19):6855-61. PMID: 20415445.
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      58. Nicolaou K, Adsool VA, Hale CR. An expedient procedure for the oxidative cleavage of olefinic bonds with PhI(OAc)2, NMO, and catalytic OsO4. Org Lett. 2010 Apr 2; 12(7):1552-5. PMID: 20192259.
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      59. Nicolaou K, Ding H, Richard JA, Chen DY. Total synthesis of echinopines A and B. J Am Chem Soc. 2010 Mar 24; 132(11):3815-8. PMID: 20184316.
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      60. Hayden AE, Paton RS, Becker J, Lim YH, Nicolaou K, Houk KN. Origins of regioselectivity of Diels-Alder reactions for the synthesis of bisanthraquinone antibiotic BE-43472B. J Org Chem. 2010 Feb 5; 75(3):922-8. PMID: 20027998.
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      61. Cao Z, LePage KT, Frederick MO, Nicolaou K, Murray TF. Involvement of caspase activation in azaspiracid-induced neurotoxicity in neocortical neurons. Toxicol Sci. 2010 Apr; 114(2):323-34. PMID: 20047973.
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      62. Nicolaou K, Li A, Edmonds DJ, Tria GS, Ellery SP. Total synthesis of platensimycin and related natural products. J Am Chem Soc. 2009 Nov 25; 131(46):16905-18. PMID: 19874023.
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      63. Nicolaou K, Tria GS, Edmonds DJ, Kar M. Total syntheses of (+/-)-platencin and (-)-platencin. J Am Chem Soc. 2009 Nov 4; 131(43):15909-17. PMID: 19824676.
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      64. Starosta AL, Qin H, Mikolajka A, Leung GY, Schwinghammer K, Nicolaou K, Chen DY, Cooperman BS, Wilson DN. Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays. Chem Biol. 2009 Oct 30; 16(10):1087-96. PMID: 19875082.
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      65. Nicolaou K, Dong L, Deng L, Talbot AC, Chen DY. Synthesis of functionalized maoecrystal V core structures. Chem Commun (Camb). 2010 Jan 7; 46(1):70-2. PMID: 20024296.
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      66. Nicolaou K, Becker J, Lim YH, Lemire A, Neubauer T, Montero A. Total synthesis and biological evaluation of (+)- and (-)-bisanthraquinone antibiotic BE-43472B and related compounds. J Am Chem Soc. 2009 Oct 21; 131(41):14812-26. PMID: 19778008.
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      67. Hirschmann RF, Nicolaou K, Angeles AR, Chen JS, Smith AB. The beta-D-glucose scaffold as a beta-turn mimetic. Acc Chem Res. 2009 Oct 20; 42(10):1511-20. PMID: 19624154.
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      68. Vale C, Nicolaou K, Frederick MO, Vieytes MR, Botana LM. Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons. Toxicol Sci. 2010 Jan; 113(1):158-68. PMID: 19815690.
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      69. Narita T, Yin S, Gelin CF, Moreno CS, Yepes M, Nicolaou K, Van Meir EG. Identification of a novel small molecule HIF-1alpha translation inhibitor. Clin Cancer Res. 2009 Oct 1; 15(19):6128-36. PMID: 19789328.
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      70. Nicolaou K, Peng XS, Sun YP, Polet D, Zou B, Lim CS, Chen DY. Total synthesis and biological evaluation of cortistatins A and J and analogues thereof. J Am Chem Soc. 2009 Aug 5; 131(30):10587-97. PMID: 19722632.
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      71. Frederick MO, De Lamo Marin S, Janda KD, Nicolaou K, Dickerson TJ. Monoclonal antibodies with orthogonal azaspiracid epitopes. Chembiochem. 2009 Jul 6; 10(10):1625-9. PMID: 19492388.
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      72. Nicolaou K, Chen JS. The art of total synthesis through cascade reactions. Chem Soc Rev. 2009 Nov; 38(11):2993-3009. PMID: 19847336.
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      73. Nicolaou K, Krasovskiy A, Majumder U, Trépanier VE, Chen DY. New synthetic technologies for the construction of heterocycles and tryptamines. J Am Chem Soc. 2009 Mar 18; 131(10):3690-9. PMID: 19243142.
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      74. Jeso V, Nicolaou K. Total Synthesis of Tovophyllin B. Tetrahedron Lett. 2009 Mar 18; 50(11):1161-1163. PMID: 20161287.
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      75. Nicolaou K, Reingruber R, Sarlah D, Bräse S. Enantioselective intramolecular Friedel-Crafts-type alpha-arylation of aldehydes. J Am Chem Soc. 2009 Feb 18; 131(6):2086-7. PMID: 19173649.
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      76. Nicolaou K. Inspirations, discoveries, and future perspectives in total synthesis. J Org Chem. 2009 Feb 6; 74(3):951-72. PMID: 19152273.
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      77. Nicolaou K, Dalby SM, Li S, Suzuki T, Chen DY. Total synthesis of (+)-haplophytine. Angew Chem Int Ed Engl. 2009; 48(41):7616-20. PMID: 19746386.
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      78. Nicolaou K, Ellery SP, Chen JS. Samarium diiodide mediated reactions in total synthesis. Angew Chem Int Ed Engl. 2009; 48(39):7140-65. PMID: 19714695.
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      79. Nicolaou K, Chen JS, Edmonds DJ, Estrada AA. Recent advances in the chemistry and biology of naturally occurring antibiotics. Angew Chem Int Ed Engl. 2009; 48(4):660-719. PMID: 19130444.
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      80. Nicolaou K, Wu TR, Kang Q, Chen DY. Total synthesis of hopeahainol A and hopeanol. Angew Chem Int Ed Engl. 2009; 48(19):3440-3. PMID: 19280619.
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      81. Cee VJ, Chen DY, Lee MR, Nicolaou K. Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11. Angew Chem Int Ed Engl. 2009; 48(47):8952-7. PMID: 19844931.
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      82. Nicolaou K, Harrison ST, Chen JS. Discoveries from the Abyss: The Abyssomicins and Their Total Synthesis. Synthesis (Stuttg). 2009 Jan 1; 2009(1):33-42. PMID: 20047014.
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      83. Nicolaou K, Chen JS, Dalby SM. From nature to the laboratory and into the clinic. Bioorg Med Chem. 2009 Mar 15; 17(6):2290-303. PMID: 19028103.
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      84. Nicolaou K, Dalby SM, Majumder U. A concise asymmetric total synthesis of aspidophytine. J Am Chem Soc. 2008 Nov 12; 130(45):14942-3. PMID: 18855359.
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      85. Vale C, Wandscheer C, Nicolaou K, Frederick MO, Alfonso C, Vieytes MR, Botana LM. Cytotoxic effect of azaspiracid-2 and azaspiracid-2-methyl ester in cultured neurons: involvement of the c-Jun N-terminal kinase. J Neurosci Res. 2008 Oct; 86(13):2952-62. PMID: 18500761.
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      86. Nicolaou K, Stepan AF, Lister T, Li A, Montero A, Tria GS, Turner CI, Tang Y, Wang J, Denton RM, Edmonds DJ. Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity. J Am Chem Soc. 2008 Oct 1; 130(39):13110-9. PMID: 18771264.
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      87. Vilariño N, Nicolaou K, Frederick MO, Cagide E, Alfonso C, Alonso E, Vieytes MR, Botana LM. Azaspiracid substituent at C1 is relevant to in vitro toxicity. Chem Res Toxicol. 2008 Sep; 21(9):1823-31. PMID: 18707138.
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      88. Nicolaou K, Toh QY, Chen DY. An expedient asymmetric synthesis of platencin. J Am Chem Soc. 2008 Aug 27; 130(34):11292-3. PMID: 18665593.
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      89. Nicolaou K, Wu TR, Sarlah D, Shaw DM, Rowcliffe E, Burton DR. Total synthesis, revised structure, and biological evaluation of biyouyanagin A and analogues thereof. J Am Chem Soc. 2008 Aug 20; 130(33):11114-21. PMID: 18646750.
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      90. Nicolaou K, Leung GY, Dethe DH, Guduru R, Sun YP, Lim CS, Chen DY. Chemical synthesis and biological evaluation of palmerolide A analogues. J Am Chem Soc. 2008 Jul 30; 130(30):10019-23. PMID: 18598030.
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      91. Nicolaou K, Lister T, Denton RM, Gelin CF. Total synthesis of atrochamins F, H, I, and J through cascade reactions. Tetrahedron. 2008 May 19; 64(21):4736-4757. PMID: 19461992.
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      92. Nicolaou K, Frederick MO, Burtoloso AC, Denton RM, Rivas F, Cole KP, Aversa RJ, Gibe R, Umezawa T, Suzuki T. Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin. J Am Chem Soc. 2008 Jun 11; 130(23):7466-76. PMID: 18481856.
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      93. Nicolaou K, Dethe DH, Chen DY. Total syntheses of amythiamicins A, B and C. Chem Commun (Camb). 2008 Jun 21; (23):2632-4. PMID: 18535690.
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      94. Nicolaou K, Sun YP, Guduru R, Banerji B, Chen DY. Total synthesis of the originally proposed and revised structures of palmerolide A and isomers thereof. J Am Chem Soc. 2008 Mar 19; 130(11):3633-44. PMID: 18298117.
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      95. Nicolaou K, Dethe DH, Leung GY, Zou B, Chen DY. Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1. Chem Asian J. 2008 Feb 1; 3(2):413-29. PMID: 18188863.
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      96. Nicolaou K, Sun YP, Peng XS, Polet D, Chen DY. Total synthesis of (+)-cortistatin A. Angew Chem Int Ed Engl. 2008; 47(38):7310-3. PMID: 18704899.
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      97. Nicolaou K, Chen JS, Zhang H, Montero A. Asymmetric synthesis and biological properties of uncialamycin and 26-epi-uncialamycin. Angew Chem Int Ed Engl. 2008; 47(1):185-9. PMID: 18058881.
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      98. Nicolaou K, Pappo D, Tsang KY, Gibe R, Chen DY. A chiral pool based synthesis of platensimycin. Angew Chem Int Ed Engl. 2008; 47(5):944-6. PMID: 18176919.
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      99. Nicolaou K, Frederick MO, Aversa RJ. The continuing saga of the marine polyether biotoxins. Angew Chem Int Ed Engl. 2008; 47(38):7182-225. PMID: 18763702.
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      100. Nicolaou K, Krasovskiy A, Trépanier VE, Chen DY. An expedient strategy for the synthesis of tryptamines and other heterocycles. Angew Chem Int Ed Engl. 2008; 47(22):4217-20. PMID: 18404758.
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      101. Nicolaou K, Tang Y, Wang J, Stepan AF, Li A, Montero A. Total synthesis and antibacterial properties of carbaplatensimycin. J Am Chem Soc. 2007 Dec 5; 129(48):14850-1. PMID: 17988130.
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      102. Nicolaou K, Li H, Nold AL, Pappo D, Lenzen A. Total synthesis of kinamycins C, F, and J. J Am Chem Soc. 2007 Aug 29; 129(34):10356-7. PMID: 17676854.
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      103. Nicolaou K, Estrada AA, Freestone GC, Lee SH, Alvarez-Mico X. New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems. Tetrahedron. 2007 Jul 2; 63(27):6088-6114. PMID: 20606766.
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      104. Vilariño N, Nicolaou K, Frederick MO, Vieytes MR, Botana LM. Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells. Biochem Pharmacol. 2007 Jul 15; 74(2):327-35. PMID: 17485074.
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      105. Altmann KH, Pfeiffer B, Arseniyadis S, Pratt BA, Nicolaou K. The chemistry and biology of epothilones--the wheel keeps turning. ChemMedChem. 2007 Apr; 2(4):396-423. PMID: 17340668.
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      106. Nicolaou K, Lim YH, Piper JL, Papageorgiou CD. Total syntheses of 2,2'-epi-cytoskyrin A, rugulosin, and the alleged structure of rugulin. J Am Chem Soc. 2007 Apr 4; 129(13):4001-13. PMID: 17355133.
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      107. Vale C, Nicolaou K, Frederick MO, Gómez-Limia B, Alfonso A, Vieytes MR, Botana LM. Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study. J Med Chem. 2007 Jan 25; 50(2):356-63. PMID: 17228878.
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      108. Nicolaou K, Nold AL, Milburn RR, Schindler CS, Cole KP, Yamaguchi J. Total synthesis of marinomycins A-C and of their monomeric counterparts monomarinomycin A and iso-monomarinomycin A. J Am Chem Soc. 2007 Feb 14; 129(6):1760-8. PMID: 17249678.
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      109. Nicolaou K, Harrison ST. Total synthesis of abyssomicin C, atrop-abyssomicin C, and abyssomicin D: implications for natural origins of atrop-abyssomicin C. J Am Chem Soc. 2007 Jan 17; 129(2):429-40. PMID: 17212423.
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      110. Nicolaou K, Frederick MO. On the structure of maitotoxin. Angew Chem Int Ed Engl. 2007; 46(28):5278-82. PMID: 17469088.
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      111. Nicolaou K, Zhang H, Chen JS, Crawford JJ, Pasunoori L. Total synthesis and stereochemistry of uncialamycin. Angew Chem Int Ed Engl. 2007; 46(25):4704-7. PMID: 17497617.
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      112. Vale C, Gómez-Limia B, Nicolaou K, Frederick MO, Vieytes MR, Botana LM. The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1. Cell Physiol Biochem. 2007; 20(6):957-66. PMID: 17982278.
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      113. Nicolaou K, Guduru R, Sun YP, Banerji B, Chen DY. Total synthesis of the originally proposed and revised structures of palmerolide A. Angew Chem Int Ed Engl. 2007; 46(31):5896-900. PMID: 17600809.
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      114. Nicolaou K, Majumder U, Roche SP, Chen DY. Construction of the "left domain" of haplophytine. Angew Chem Int Ed Engl. 2007; 46(25):4715-8. PMID: 17559182.
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      115. Nicolaou K, Cole KP, Frederick MO, Aversa RJ, Denton RM. Chemical synthesis of the GHIJK ring system and further experimental support for the originally assigned structure of maitotoxin. Angew Chem Int Ed Engl. 2007; 46(46):8875-9. PMID: 17943950.
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      116. Nicolaou K, Zou B, Dethe DH, Li DB, Chen DY. Total synthesis of antibiotics GE2270A and GE2270T. Angew Chem Int Ed Engl. 2006 Nov 27; 45(46):7786-92. PMID: 17061302.
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      117. Vilariño N, Nicolaou K, Frederick MO, Cagide E, Ares IR, Louzao MC, Vieytes MR, Botana LM. Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies. Chem Res Toxicol. 2006 Nov; 19(11):1459-66. PMID: 17112233.
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      118. Nicolaou K, Estrada AA, Lee SH, Freestone GC. Synthesis of highly substituted N-hydroxyindoles through 1,5-addition of carbon nucleophiles to in situ generated unsaturated nitrones. Angew Chem Int Ed Engl. 2006 Aug 11; 45(32):5364-8. PMID: 16847981.
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      119. Hamel E, Day BW, Miller JH, Jung MK, Northcote PT, Ghosh AK, Curran DP, Cushman M, Nicolaou K, Paterson I, Sorensen EJ. Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. Mol Pharmacol. 2006 Nov; 70(5):1555-64. PMID: 16887932.
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      120. Nicolaou K, Frederick MO, Loizidou EZ, Petrovic G, Cole KP, Koftis TV, Yamada YM. Second-generation total synthesis of azaspiracids-1, -2, and -3. Chem Asian J. 2006 Jul 17; 1(1-2):245-63. PMID: 17441061.
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      121. Alfonso A, Vieytes MR, Ofuji K, Satake M, Nicolaou K, Frederick MO, Botana LM. Azaspiracids modulate intracellular pH levels in human lymphocytes. Biochem Biophys Res Commun. 2006 Aug 4; 346(3):1091-9. PMID: 16793022.
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      122. Nicolaou K, Harrison ST. Total synthesis of abyssomicin C and atrop-abyssomicin C. Angew Chem Int Ed Engl. 2006 May 12; 45(20):3256-60. PMID: 16634106.
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      123. Nicolaou K, Bulger PG, Brenzovich WE. Synthesis of iso-epoxy-amphidinolide N and des-epoxy-caribenolide I structures. Revised strategy and final stages. Org Biomol Chem. 2006 Jun 7; 4(11):2158-83. PMID: 16729127.
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      124. Nicolaou K, Brenzovich WE, Bulger PG, Francis TM. Synthesis of iso-epoxy-amphidinolide N and des-epoxy-caribenolide I structures. Initial forays. Org Biomol Chem. 2006 Jun 7; 4(11):2119-57. PMID: 16729126.
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      125. Nicolaou K, Frederick MO, Petrovic G, Cole KP, Loizidou EZ. Total synthesis and confirmation of the revised structures of azaspiracid-2 and azaspiracid-3. Angew Chem Int Ed Engl. 2006 Apr 10; 45(16):2609-15. PMID: 16548033.
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      126. Nicolaou K, Lizos DE, Kim DW, Schlawe D, de Noronha RG, Longbottom DA, Rodriquez M, Bucci M, Cirino G. Total synthesis and biological evaluation of halipeptins A and D and analogues. J Am Chem Soc. 2006 Apr 5; 128(13):4460-70. PMID: 16569024.
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      127. Nicolaou K, Denton RM, Lenzen A, Edmonds DJ, Li A, Milburn RR, Harrison ST. Stereocontrolled synthesis of model core systems of lomaiviticins A and B. Angew Chem Int Ed Engl. 2006 Mar 20; 45(13):2076-81. PMID: 16496276.
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      128. Nicolaou K, Koftis TV, Vyskocil S, Petrovic G, Tang W, Frederick MO, Chen DY, Li Y, Ling T, Yamada YM. Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1. J Am Chem Soc. 2006 Mar 8; 128(9):2859-72. PMID: 16506764.
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      129. Nicolaou K, Chen DY, Li Y, Uesaka N, Petrovic G, Koftis TV, Bernal F, Frederick MO, Govindasamy M, Ling T, Pihko PM, Tang W, Vyskocil S. Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product. J Am Chem Soc. 2006 Feb 22; 128(7):2258-67. PMID: 16478179.
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      130. Nicolaou K, Pihko PM, Bernal F, Frederick MO, Qian W, Uesaka N, Diedrichs N, Hinrichs J, Koftis TV, Loizidou E, Petrovic G, Rodriquez M, Sarlah D, Zou N. Total synthesis and structural elucidation of azaspiracid-1. Construction of key building blocks for originally proposed structure. J Am Chem Soc. 2006 Feb 22; 128(7):2244-57. PMID: 16478178.
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      131. Nicolaou K, Pratt BA, Arseniyadis S, Wartmann M, O'Brate A, Giannakakou P. Molecular design and chemical synthesis of a highly potent epothilone. ChemMedChem. 2006 Jan; 1(1):41-4. PMID: 16892332.
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      132. Nicolaou K, Zak M, Rahimipour S, Estrada AA, Lee SH, O'Brate A, Giannakakou P, Ghadiri MR. Discovery of a biologically active thiostrepton fragment. J Am Chem Soc. 2005 Nov 2; 127(43):15042-4. PMID: 16248640.
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      133. Nicolaou K, Schlawe D, Kim DW, Longbottom DA, de Noronha RG, Lizos DE, Manam RR, Faulkner DJ. Total synthesis of halipeptins: isolation of halipeptin D and synthesis of oxazoline halipeptin analogues. Chemistry. 2005 Oct 21; 11(21):6197-211. PMID: 16075448.
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      134. Nicolaou K, Mathison CJ. Synthesis of imides, N-acyl vinylogous carbamates and ureas, and nitriles by oxidation of amides and amines with Dess-Martin periodinane. Angew Chem Int Ed Engl. 2005 Sep 19; 44(37):5992-7. PMID: 16124020.
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      135. Nicolaou K. Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. J Med Chem. 2005 Sep 8; 48(18):5613-38. PMID: 16134928.
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      136. Nicolaou K, Zak M, Safina BS, Estrada AA, Lee SH, Nevalainen M. Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis. J Am Chem Soc. 2005 Aug 10; 127(31):11176-83. PMID: 16076225.
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      137. Nicolaou K, Safina BS, Zak M, Lee SH, Nevalainen M, Bella M, Estrada AA, Funke C, Zécri FJ, Bulat S. Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks. J Am Chem Soc. 2005 Aug 10; 127(31):11159-75. PMID: 16076224.
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      138. Nicolaou K, Montagnon T, Vassilikogiannakis G, Mathison CJ. The total synthesis of coleophomones B, C, and D. J Am Chem Soc. 2005 Jun 22; 127(24):8872-88. PMID: 15954796.
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      139. Nicolaou K, Carenzi GE, Jeso V. Construction of highly functionalized medium-sized rings: synthesis of hyperforin and perforatumone model systems. Angew Chem Int Ed Engl. 2005 Jun 20; 44(25):3895-9. PMID: 15892032.
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      140. Nicolaou K, Lee SH, Estrada AA, Zak M. Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system. Angew Chem Int Ed Engl. 2005 Jun 13; 44(24):3736-40. PMID: 15892095.
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      141. Nicolaou K, Sasmal PK, Roecker AJ, Sun XW, Mandal S, Converso A. Studies toward the synthesis of azadirachtin, part 1: total synthesis of a fully functionalized ABC ring framework and coupling with a norbornene domain. Angew Chem Int Ed Engl. 2005 May 30; 44(22):3443-7. PMID: 15846829.
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      142. Nicolaou K, Sasmal PK, Koftis TV, Converso A, Loizidou E, Kaiser F, Roecker AJ, Dellios CC, Sun XW, Petrovic G. Studies toward the synthesis of azadirachtin, part 2: construction of fully functionalized ABCD ring frameworks and unusual intramolecular reactions induced by close-proximity effects. Angew Chem Int Ed Engl. 2005 May 30; 44(22):3447-52. PMID: 15849805.
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      143. Nicolaou K, Estrada AA, Zak M, Lee SH, Safina BS. A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide. Angew Chem Int Ed Engl. 2005 Feb 18; 44(9):1378-82. PMID: 15674985.
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      144. Nicolaou K, Snyder SA. Chasing molecules that were never there: misassigned natural products and the role of chemical synthesis in modern structure elucidation. Angew Chem Int Ed Engl. 2005 Feb 4; 44(7):1012-44. PMID: 15688428.
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      145. Tan C, de Noronha RG, Roecker AJ, Pyrzynska B, Khwaja F, Zhang Z, Zhang H, Teng Q, Nicholson AC, Giannakakou P, Zhou W, Olson JJ, Pereira MM, Nicolaou K, Van Meir EG. Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway. Cancer Res. 2005 Jan 15; 65(2):605-12. PMID: 15695405.
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      146. Nicolaou K, Snyder SA, Longbottom DA, Nalbandian AZ, Huang X. New uses for the Burgess reagent in chemical synthesis: methods for the facile and stereoselective formation of sulfamidates, glycosylamines, and sulfamides. Chemistry. 2004 Nov 5; 10(22):5581-606. PMID: 15470695.
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      147. Nicolaou K, Hao J, Reddy MV, Rao PB, Rassias G, Snyder SA, Huang X, Chen DY, Brenzovich WE, Giuseppone N, O'Brate A, Giannakakou P. Chemistry and biology of diazonamide A: second total synthesis and biological investigations. J Am Chem Soc. 2004 Oct 13; 126(40):12897-906. PMID: 15469287.
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      148. Nicolaou K, Chen DY, Huang X, Ling T, Bella M, Snyder SA. Chemistry and biology of diazonamide A: first total synthesis and confirmation of the true structure. J Am Chem Soc. 2004 Oct 13; 126(40):12888-96. PMID: 15469286.
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      149. Nicolaou K, Zak M, Safina BS, Lee SH, Estrada AA. Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis. Angew Chem Int Ed Engl. 2004 Sep 27; 43(38):5092-7. PMID: 15372630.
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      150. Nicolaou K, Safina BS, Zak M, Estrada AA, Lee SH. Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle. Angew Chem Int Ed Engl. 2004 Sep 27; 43(38):5087-92. PMID: 15372631.
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      151. Nicolaou K, Vyskocil S, Koftis TV, Yamada YM, Ling T, Chen DY, Tang W, Petrovic G, Frederick MO, Li Y, Satake M. Structural revision and total synthesis of azaspiracid-1, part 1: intelligence gathering and tentative proposal. Angew Chem Int Ed Engl. 2004 Aug 20; 43(33):4312-8. PMID: 15368380.
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      152. Nicolaou K, Koftis TV, Vyskocil S, Petrovic G, Ling T, Yamada YM, Tang W, Frederick MO. Structural revision and total synthesis of azaspiracid-1, part 2: definition of the ABCD domain and total synthesis. Angew Chem Int Ed Engl. 2004 Aug 20; 43(33):4318-24. PMID: 15368381.
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      153. Nicolaou K, Snyder SA, Huang X, Simonsen KB, Koumbis AE, Bigot A. Studies toward diazonamide A: initial synthetic forays directed toward the originally proposed structure. J Am Chem Soc. 2004 Aug 18; 126(32):10162-73. PMID: 15303892.
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      154. Nicolaou K, Snyder SA, Giuseppone N, Huang X, Bella M, Reddy MV, Rao PB, Koumbis AE, O'Brate A, Giannakakou P. Studies toward diazonamide A: development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure. J Am Chem Soc. 2004 Aug 18; 126(32):10174-82. PMID: 15303893.
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      155. Nicolaou K, Snyder SA, Nalbandian AZ, Longbottom DA. A new method for the stereoselective synthesis of alpha- and beta-glycosylamines using the Burgess reagent. J Am Chem Soc. 2004 May 26; 126(20):6234-5. PMID: 15149212.
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      156. Nicolaou K, Sasmal PK, Xu H. Biomimetically inspired total synthesis and structure activity relationships of 1-O-methyllateriflorone. 6 pi electrocyclizations in organic synthesis. J Am Chem Soc. 2004 May 5; 126(17):5493-501. PMID: 15113221.
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      157. Nicolaou K, Mathison CJ, Montagnon T. o-Iodoxybenzoic acid (IBX) as a viable reagent in the manipulation of nitrogen- and sulfur-containing substrates: scope, generality, and mechanism of IBX-mediated amine oxidations and dithiane deprotections. J Am Chem Soc. 2004 Apr 28; 126(16):5192-201. PMID: 15099102.
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      158. Buey RM, Díaz JF, Andreu JM, O'Brate A, Giannakakou P, Nicolaou K, Sasmal PK, Ritzén A, Namoto K. Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity. Chem Biol. 2004 Feb; 11(2):225-36. PMID: 15123284.
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      159. Nicolaou K, Gray DL, Tae J. Total synthesis of hamigerans and analogues thereof. Photochemical generation and Diels-Alder trapping of hydroxy-o-quinodimethanes. J Am Chem Soc. 2004 Jan 21; 126(2):613-27. PMID: 14719961.
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      160. Nicolaou K, Gray DL. Total synthesis of hybocarpone and analogues thereof. A facile dimerization of naphthazarins to pentacyclic systems. J Am Chem Soc. 2004 Jan 21; 126(2):607-12. PMID: 14719960.
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      161. Nicolaou K, Li Y, Sugita K, Monenschein H, Guntupalli P, Mitchell HJ, Fylaktakidou KC, Vourloumis D, Giannakakou P, O'Brate A. Total synthesis of apoptolidin: completion of the synthesis and analogue synthesis and evaluation. J Am Chem Soc. 2003 Dec 17; 125(50):15443-54. PMID: 14664590.
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      162. Nicolaou K, Fylaktakidou KC, Monenschein H, Li Y, Weyershausen B, Mitchell HJ, Wei HX, Guntupalli P, Hepworth D, Sugita K. Total synthesis of apoptolidin: construction of enantiomerically pure fragments. J Am Chem Soc. 2003 Dec 17; 125(50):15433-42. PMID: 14664589.
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      163. Nicolaou K, Kim DW, Baati R, O'Brate A, Giannakakou P. Total synthesis and biological evaluation of (-)apicularen A and analogues thereof. Chemistry. 2003 Dec 15; 9(24):6177-91. PMID: 14679529.
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      164. Nicolaou K, Sasmal PK, Xu H, Namoto K, Ritzén A. Total synthesis of 1-O-methyllateriflorone. Angew Chem Int Ed Engl. 2003 Sep 15; 42(35):4225-9. PMID: 14502742.
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      165. Nicolaou K, Mathison CJ, Montagnon T. New reactions of IBX: oxidation of nitrogen- and sulfur-containing substrates to afford useful synthetic intermediates. Angew Chem Int Ed Engl. 2003 Sep 5; 42(34):4077-82. PMID: 12973775.
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      166. Nicolaou K, Chen DY, Li Y, Qian W, Ling T, Vyskocil S, Koftis TV, Govindasamy M, Uesaka N. Total synthesis of the proposed azaspiracid-1 structure, part 2: coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis. Angew Chem Int Ed Engl. 2003 Aug 11; 42(31):3649-53. PMID: 12916037.
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      167. Nicolaou K, Roecker AJ, Monenschein H, Guntupalli P, Follmann M. Studies towards the synthesis of azadirachtin: enantioselective entry into the azadirachtin framework through cascade reactions. Angew Chem Int Ed Engl. 2003 Aug 11; 42(31):3637-42. PMID: 12916035.
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      168. Nicolaou K, Li Y, Uesaka N, Koftis TV, Vyskocil S, Ling T, Govindasamy M, Qian W, Bernal F, Chen DY. Total synthesis of the proposed azaspiracid-1 structure, part 1: construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments. Angew Chem Int Ed Engl. 2003 Aug 11; 42(31):3643-8. PMID: 12916036.
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      169. Nicolaou K, Sasmal PK, Rassias G, Reddy MV, Altmann KH, Wartmann M, O'Brate A, Giannakakou P. Design, synthesis, and biological properties of highly potent epothilone B analogues. Angew Chem Int Ed Engl. 2003 Aug 4; 42(30):3515-20. PMID: 12900969.
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      170. Nicolaou K, Nevalainen M, Zak M, Bulat S, Bella M, Safina BS. Synthetic studies on thiostrepton: construction of thiostrepton analogues with the thiazoline-containing macrocycle. Angew Chem Int Ed Engl. 2003 Jul 28; 42(29):3418-24. PMID: 12888975.
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      171. Nicolaou K, Bheema Rao P, Hao J, Reddy MV, Rassias G, Huang X, Chen DY, Snyder SA. The second total synthesis of diazonamide A. Angew Chem Int Ed Engl. 2003 Apr 17; 42(15):1753-8. PMID: 12707898.
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      172. Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou K, Evans RM. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr; 11(4):1079-92. PMID: 12718892.
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      173. Nicolaou K, Evans RM, Roecker AJ, Hughes R, Downes M, Pfefferkorn JA. Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org Biomol Chem. 2003 Mar 21; 1(6):908-20. PMID: 12929628.
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      174. Nicolaou K. Profile. K. C. Nicolaou. Org Biomol Chem. 2003 Mar 21; 1(6):x-xi. PMID: 12929625.
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      175. Nicolaou K, Montagnon T, Snyder SA. Tandem reactions, cascade sequences, and biomimetic strategies in total synthesis. Chem Commun (Camb). 2003 Mar 7; (5):551-64. PMID: 12669826.
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      176. Nicolaou K, Roecker AJ, Hughes R, van Summeren R, Pfefferkorn JA, Winssinger N. Novel strategies for the solid phase synthesis of substituted indolines and indoles. Bioorg Med Chem. 2003 Feb 6; 11(3):465-76. PMID: 12517442.
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      177. Bocci G, Nicolaou K, Kerbel RS. Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. Cancer Res. 2002 Dec 1; 62(23):6938-43. PMID: 12460910.
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      178. Nicolaou K, Bella M, Chen DY, Huang X, Ling T, Snyder SA. Total synthesis of diazonamide A. Angew Chem Int Ed Engl. 2002 Sep 16; 41(18):3495-9. PMID: 12298077.
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      179. Nicolaou K, Boddy CN. Atropselective macrocyclization of diaryl ether ring systems: application to the synthesis of vancomycin model systems. J Am Chem Soc. 2002 Sep 4; 124(35):10451-5. PMID: 12197747.
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      180. Nicolaou K, Vassilikogiannakis G, Montagnon T. The total synthesis of coleophomones B and C. Angew Chem Int Ed Engl. 2002 Sep 2; 41(17):3276-81. PMID: 12207414.
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      181. Nicholas GM, Eckman LL, Ray S, Hughes RO, Pfefferkorn JA, Barluenga S, Nicolaou K, Bewley CA. Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase. Bioorg Med Chem Lett. 2002 Sep 2; 12(17):2487-90. PMID: 12161164.
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      182. Wrasidlo W, Gaedicke G, Guy RK, Renaud J, Pitsinos E, Nicolaou K, Reisfeld RA, Lode HN. A novel 2'-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models. Bioconjug Chem. 2002 Sep-Oct; 13(5):1093-9. PMID: 12236791.
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      183. Nicolaou K, Baran PS. The CP molecule labyrinth: a paradigm of how endeavors in total synthesis lead to discoveries and inventions in organic synthesis. Angew Chem Int Ed Engl. 2002 Aug 2; 41(15):2678-720. PMID: 12203464.
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      184. Giannakakou P, Nakano M, Nicolaou K, O'Brate A, Yu J, Blagosklonny MV, Greber UF, Fojo T. Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. Proc Natl Acad Sci U S A. 2002 Aug 6; 99(16):10855-60. PMID: 12145320.
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      185. Nicolaou K, Follmann M, Roecker AJ, Hunt KW. Model studies towards azadirachtin: part 1. Construction of the crowded C8-C14 bond by radical chemistry. Angew Chem Int Ed Engl. 2002 Jun 17; 41(12):2103-6. PMID: 19746610.
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      186. Nicolaou K, Roecker AJ, Follmann M, Baati R. Model studies towards azadirachtin: part 2. Construction of the crowded C8-C14 bond by transition metal chemistry. Angew Chem Int Ed Engl. 2002 Jun 17; 41(12):2107-10. PMID: 19746611.
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      187. Nicolaou K, Nevalainen M, Safina BS, Zak M, Bulat S. A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton. Angew Chem Int Ed Engl. 2002 Jun 3; 41(11):1941-5. PMID: 19750640.
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      188. Nicolaou K, Montagnon T, Ulven T, Baran PS, Zhong YL, Sarabia F. Novel chemistry of alpha-tosyloxy ketones: applications to the solution- and solid-phase synthesis of privileged heterocycle and enediyne libraries. J Am Chem Soc. 2002 May 22; 124(20):5718-28. PMID: 12010045.
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      189. Nicolaou K, Snyder SA, Montagnon T, Vassilikogiannakis G. The Diels--Alder reaction in total synthesis. Angew Chem Int Ed Engl. 2002 May 17; 41(10):1668-98. PMID: 19750686.
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      190. Nicolaou K, Montagnon T, Baran PS. HIO3 and I2O5: mild and selective alternative reagents to IBX for the dehydrogenation of aldehydes and ketones. Angew Chem Int Ed Engl. 2002 Apr 15; 41(8):1386-9. PMID: 19750773.
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      191. Nicolaou K, Montagnon T, Baran PS. Modulation of the reactivity profile of IBX by ligand complexation: ambient temperature dehydrogenation of aldehydes and ketones to alpha,beta-unsaturated carbonyl compounds. Angew Chem Int Ed Engl. 2002 Mar 15; 41(6):993-6. PMID: 12491291.
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      192. Nicolaou K, Gray DL, Montagnon T, Harrison ST. Oxidation of silyl enol ethers by using IBX and IBX.N-oxide complexes: a mild and selective reaction for the synthesis of enones. Angew Chem Int Ed Engl. 2002 Mar 15; 41(6):996-1000. PMID: 12491292.
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      193. Nicolaou K, Baran PS, Zhong YL, Fong KC, Choi HS. Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 2. Model studies for the construction of key structural elements and first-generation strategy. J Am Chem Soc. 2002 Mar 13; 124(10):2190-201. PMID: 11878973.
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      194. Nicolaou K, Jung J, Yoon WH, Fong KC, Choi HS, He Y, Zhong YL, Baran PS. Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 1. Racemic and asymmetric synthesis of bicyclo[4.3.1] key building blocks. J Am Chem Soc. 2002 Mar 13; 124(10):2183-9. PMID: 11878972.
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      195. Nicolaou K, Zhong YL, Baran PS, Jung J, Choi HS, Yoon WH. Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 3. Completion and synthesis of advanced analogues. J Am Chem Soc. 2002 Mar 13; 124(10):2202-11. PMID: 11878974.
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      196. Nicolaou K, Baran PS, Zhong YL, Sugita K. Iodine(V) reagents in organic synthesis. Part 1. Synthesis of polycyclic heterocycles via Dess-Martin periodinane-mediated cascade cyclization: generality, scope, and mechanism of the reaction. J Am Chem Soc. 2002 Mar 13; 124(10):2212-20. PMID: 11878975.
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      197. Nicolaou K, Sugita K, Baran PS, Zhong YL. Iodine(V) reagents in organic synthesis. Part 2. Access to complex molecular architectures via Dess-Martin periodinane-generated o-imidoquinones. J Am Chem Soc. 2002 Mar 13; 124(10):2221-32. PMID: 11878976.
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      198. Nicolaou K, Baran PS, Zhong YL, Barluenga S, Hunt KW, Kranich R, Vega JA. Iodine(V) reagents in organic synthesis. Part 3. New routes to heterocyclic compounds via o-iodoxybenzoic acid-mediated cyclizations: generality, scope, and mechanism. J Am Chem Soc. 2002 Mar 13; 124(10):2233-44. PMID: 11878977.
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      199. Nicolaou K, Montagnon T, Baran PS, Zhong YL. Iodine(V) reagents in organic synthesis. Part 4. o-Iodoxybenzoic acid as a chemospecific tool for single electron transfer-based oxidation processes. J Am Chem Soc. 2002 Mar 13; 124(10):2245-58. PMID: 11878978.
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      200. Schreiber SL, Nicolaou K, Davies K. Diversity-oriented organic synthesis and proteomics. New frontiers for chemistry & biology. Chem Biol. 2002 Jan; 9(1):1-2. PMID: 11841933.
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      201. Nicolaou K, Vassilikogiannakis G, Mägerlein W, Kranich R. Total synthesis of colombiasin A and determination of its absolute configuration. Chemistry. 2001 Dec 17; 7(24):5359-71. PMID: 11822436.
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      202. Nicolaou K, Qian W, Bernal F, Uesaka N, Pihko PM, Hinrichs J. Synthesis of the ABCD Ring System of Azaspiracid We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, a predoctoral fellowship from Bristol-Myers Squibb (to F.B.), postdoctoral fellowships from The Skaggs Institute for Research (to W.Q.), the Academy of Finland, the Ella and Georg Ehrnrooth Foundation and the Tauno Tönning Foundation (all to P.M.P.), and Bayer AG (to J.H.), as well as grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Nov 05; 40(21):4068-4071. PMID: 12404495.
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      203. Nicolaou K, Gray D, Tae J. Total Synthesis of Hamigerans: Part 1. Development of Synthetic Technology for the Construction of Benzannulated Polycyclic Systems by the Intramolecular Trapping of Photogenerated Hydroxy-o-quinodimethanes and Synthesis of Key Building Blocks This work was financially supported by the National Institutes of Health (USA) and The Skaggs Institute for Chemical Biology, and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Oct 01; 40(19):3675-3678. PMID: 11592219.
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      204. Nicolaou K, Gray D, Tae J. Total Synthesis of Hamigerans: Part 2. Implementation of the Intramolecular Diels-Alder Trapping of Photochemically Generated Hydroxy-o-quinodimethanes; Strategy and Completion of the Synthesis This work was financially supported by the National Institutes of Health (USA) and The Skaggs Institute for Chemical Biology, and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Oct 01; 40(19):3679-3683. PMID: 11592220.
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      205. Nicolaou K, Hughes R, Pfefferkorn JA, Barluenga S, Roecker AJ. Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA). Chemistry. 2001 Oct 1; 7(19):4280-95. PMID: 11686609.
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      206. Nicolaou K, Hughes R, Pfefferkorn JA, Barluenga S. Optimization and mechanistic studies of psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA). Chemistry. 2001 Oct 1; 7(19):4296-310. PMID: 11686610.
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      207. Newman RA, Yang J, Raymond M, Finlay V, Cabral F, Vourloumis D, Stephens LC, Troncoso P, Wu X, Logothetis CJ, Nicolaou K, Navone NM. Antitumor efficacy of 26-fluoroepothilone B against human prostate cancer xenografts. Cancer Chemother Pharmacol. 2001 Oct; 48(4):319-26. PMID: 11710633.
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      208. Nicolaou K, Namoto K, Ritzén A, Ulven T, Shoji M, Li J, D'Amico G, Liotta D, French CT, Wartmann M, Altmann KH, Giannakakou P. Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues. J Am Chem Soc. 2001 Sep 26; 123(38):9313-23. PMID: 11562214.
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      209. Nicolaou K, Ritzén A, Namoto K. Recent developments in the chemistry, biology and medicine of the epothilones. Chem Commun (Camb). 2001 Sep 7; (17):1523-35. PMID: 12240368.
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      210. Nicolaou K, Hughes R, Cho SY, Winssinger N, Labischinski H, Endermann R. Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: target-accelerated combinatorial synthesis. Chemistry. 2001 Sep 3; 7(17):3824-43. PMID: 11575783.
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      211. Nicolaou K, Cho SY, Hughes R, Winssinger N, Smethurst C, Labischinski H, Endermann R. Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria. Chemistry. 2001 Sep 3; 7(17):3798-823. PMID: 11575782.
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      212. Nicolaou K, Roecker AJ, Barluenga S, Pfefferkorn JA, Cao GQ. Discovery of novel antibacterial agents active against methicillin-resistant Staphylococcus aureus from combinatorial benzopyran libraries. Chembiochem. 2001 Jun 1; 2(6):460-5. PMID: 11828478.
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      213. Nicolaou K, Sugita K, Baran PS, Zhong YL. New Synthetic Technology for the Construction of N-Containing Quinones and Derivatives Thereof: Total Synthesis of Epoxyquinomycin B We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 May 04; 40(9):1573. PMID: 11353465.
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      214. Nicolaou K, Pihko PM, Diedrichs N, Zou N, Bernal F. Synthesis of the FGHI Ring System of Azaspiracid We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from Bristol-Myers Squibb (F.B.), postdoctoral fellowships from the Academy of Finland, the Ella and Georg Ehrnrooth Foundation, and the Tauno Tönning Foundation (all to P.M.P.), ArrayBiopharma (N.Z.), and Bayer AG (N.D.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 May 04; 40(9):1573. PMID: 11353466.
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      215. Nicolaou K, Boddy CN. Behind enemy lines. Sci Am. 2001 May; 284(5):54-61. PMID: 11341163.
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      216. Nicolaou K, Baran PS, Zhong YL. Selective oxidation at carbon adjacent to aromatic systems with IBX. J Am Chem Soc. 2001 Apr 4; 123(13):3183-5. PMID: 11457049.
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      217. Nicolaou K, Pihko PM, Diedrichs N, Zou N, Bernal F. Synthesis of the FGHI Ring System of Azaspiracid We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from Bristol-Myers Squibb (F.B.), postdoctoral fellowships from the Academy of Finland, the Ella and Georg Ehrnrooth Foundation, and the Tauno Tönning Foundation (all to P.M.P.), ArrayBiopharma (N.Z.), and Bayer AG (N.D.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Apr 01; 40(7):1262-1265. PMID: 11301444.
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      218. Nicolaou K, Namoto K, Li J, Ritzén A, Ulven T, Shoji M, Zaharevitz D, Gussio R, Sackett DL, Ward RD, Hensler A, Fojo T, Giannakakou P. Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones. Chembiochem. 2001 Jan 8; 2(1):69-75. PMID: 11828429.
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      219. Nicolaou K, Sugita K, Baran PS, Zhong YL. New Synthetic Technology for the Construction of N-Containing Quinones and Derivatives Thereof: Total Synthesis of Epoxyquinomycin B We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angew Chem Int Ed Engl. 2001 Jan 05; 40(1):207-210. PMID: 11169714.
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      220. Nicolaou K, Pfefferkorn JA. Solid phase synthesis of complex natural products and libraries thereof. Biopolymers. 2001; 60(3):171-93. PMID: 11774224.
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      221. Nicolaou K, Pfefferkorn J, Schuler F, Roecker A, Cao G, Casida J. Combinatorial synthesis of novel and potent inhibitors of NADH:ubiquinone oxidoreductase. Chem Biol. 2000 Dec; 7(12):979-92. PMID: 11137820.
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      222. Nicolaou K, Mitchell HJ, Fylaktakidou KC, Rodríguez RM, Suzuki H. Total synthesis of everninomicin 13,384-1--Part 2: synthesis of the FGHA2 fragment. Chemistry. 2000 Sep 1; 6(17):3116-48. PMID: 11002993.
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      223. Nicolaou K, Mitchell HJ, Rodríguez RM, Fylaktakidou KC, Suzuki H, Conley SR. Total synthesis of everninomicin 13,384-1--Part 3: synthesis of the DE fragment and completion of the total synthesis. Chemistry. 2000 Sep 1; 6(17):3149-65. PMID: 11002994.
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      224. Nicolaou K, Rodríguez RM, Mitchell HJ, Suzuki H, Fylaktakidou KC, Baudoin O, van Delft FL. Total synthesis of everninomicin 13,384-1--Part 1: retrosynthetic analysis and synthesis of the A1B(A)C fragment. Chemistry. 2000 Sep 1; 6(17):3095-115. PMID: 11002992.
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      225. Nicolaou K, Fylaktakidou KC, Mitchell HJ, van Delft FL, Rodríguez RM, Conley SR, Jin Z. Total synthesis of everninomicin 13,384-1--Part 4: explorations of methodology; stereocontrolled synthesis of 1,1'-disaccharides, 1,2-seleno migrations in carbohydrates, and solution- and solid-phase synthesis of 2-deoxy glycosides and orthoesters. Chemistry. 2000 Sep 1; 6(17):3166-85. PMID: 11002995.
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      226. Nicolaou K, Hepworth D, King NP, Finlay MR, Scarpelli R, Pereira MM, Bollbuck B, Bigot A, Werschkun B, Winssinger N. Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues. Chemistry. 2000 Aug 4; 6(15):2783-800. PMID: 10985727.
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      227. Nicolaou K, Scarpelli R, Bollbuck B, Werschkun B, Pereira MM, Wartmann M, Altmann KH, Zaharevitz D, Gussio R, Giannakakou P. Chemical synthesis and biological properties of pyridine epothilones. Chem Biol. 2000 Aug; 7(8):593-9. PMID: 11048950.
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      228. Giannakakou P, Gussio R, Nogales E, Downing KH, Zaharevitz D, Bollbuck B, Poy G, Sackett D, Nicolaou K, Fojo T. A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. Proc Natl Acad Sci U S A. 2000 Mar 14; 97(6):2904-9. PMID: 10688884.
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      229. Xiao XY, Li R, Zhuang H, Ewing B, Karunaratne K, Lillig J, Brown R, Nicolaou K. Solid-phase combinatorial synthesis using MicroKan reactors, Rf tagging, and directed sorting. Biotechnol Bioeng. 2000; 71(1):44-50. PMID: 10629535.
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      230. Nicolaou K, Baran PS, Zhong YL, Choi HS, Fong KC, He Y, Yoon WH. New synthetic technology for the synthesis of hindered alpha-diazoketones via acyl mesylates. Org Lett. 1999 Sep 23; 1(6):883-6. PMID: 10823217.
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      231. Nicolaou K, Pfefferkorn JA, Cao GQ, Kim S, Kessabi J. A facile method for the solution and solid-phase synthesis of substituted [3.3.1] bicycles. Org Lett. 1999 Sep 9; 1(5):807-10. PMID: 10823208.
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      232. Nicolaou K, Pfefferkorn J, Xu J, Winssinger N, Ohshima T, Kim S, Hosokawa S, Vourloumis D, van Delft F, Li T. Total synthesis and chemical biology of the sarcodictyins. Chem Pharm Bull (Tokyo). 1999 Sep; 47(9):1199-213. PMID: 10517002.
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      233. Setyawan J, Koide K, Diller TC, Bunnage ME, Taylor SS, Nicolaou K, Brunton LL. Inhibition of protein kinases by balanol: specificity within the serine/threonine protein kinase subfamily. Mol Pharmacol. 1999 Aug; 56(2):370-6. PMID: 10419556.
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      234. Nicolaou K, He Y, Fong KC, Yoon WH, Choi HS, Zhong YL, Baran PS. Novel strategies to construct the gamma-hydroxy lactone moiety of the CP molecules. Synthesis of the CP-225,917 core skeleton. Org Lett. 1999 Jul 15; 1(1):63-6. PMID: 10822534.
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      235. Nicolaou K, King NP, Finlay MR, He Y, Roschangar F, Vourloumis D, Vallberg H, Sarabia F, Ninkovic S, Hepworth D. Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy. Bioorg Med Chem. 1999 May; 7(5):665-97. PMID: 10400321.
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      236. Hamel E, Sackett DL, Vourloumis D, Nicolaou K. The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. Biochemistry. 1999 Apr 27; 38(17):5490-8. PMID: 10220336.
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      237. Narayana N, Diller TC, Koide K, Bunnage ME, Nicolaou K, Brunton LL, Xuong NH, Ten Eyck LF, Taylor SS. Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry. 1999 Feb 23; 38(8):2367-76. PMID: 10029530.
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      238. Nicolaou K, Trujillo JI, Jandeleit B, Chibale K, Rosenfeld M, Diefenbach B, Cheresh DA, Goodman SL. Design, synthesis and biological evaluation of nonpeptide integrin antagonists. Bioorg Med Chem. 1998 Aug; 6(8):1185-208. PMID: 9784861.
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      239. Lode HN, Reisfeld RA, Handgretinger R, Nicolaou K, Gaedicke G, Wrasidlo W. Targeted therapy with a novel enediyene antibiotic calicheamicin theta(I)1 effectively suppresses growth and dissemination of liver metastases in a syngeneic model of murine neuroblastoma. Cancer Res. 1998 Jul 15; 58(14):2925-8. PMID: 9679947.
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      240. Nicolaou K, Finlay MR, Ninkovic S, King NP, He Y, Li T, Sarabia F, Vourloumis D. Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones. Chem Biol. 1998 Jul; 5(7):365-72. PMID: 9662505.
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      241. Nicolaou K, Yang Z, Shi G, Gunzner JL, Agrios KA, Gärtner P. Total synthesis of brevetoxin A. Nature. 1998 Mar 19; 392(6673):264-9. PMID: 9521320.
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      242. Nicolaou K, Winssinger N, Pastor J, Ninkovic S, Sarabia F, He Y, Vourloumis D, Yang Z, Li T, Giannakakou P, Hamel E. Synthesis of epothilones A and B in solid and solution phase. Nature. 1997 May 15; 387(6630):268-72. PMID: 9153390.
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      243. Li T, Weinstein DS, Nicolaou K. The chemical end-ligation of homopyrimidine oligodeoxyribonucleotides within a DNA triple helix. Chem Biol. 1997 Mar; 4(3):209-14. PMID: 9115413.
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      244. Bunnage ME, Nicolaou K. The oxide anion accelerated retro-diels-alder reaction. Chemistry. 1997 Feb; 3(2):187-92. PMID: 24022946.
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      245. Guy R, Scott Z, Sloboda R, Nicolaou K. Fluorescent taxoids. Chem Biol. 1996 Dec; 3(12):1021-31. PMID: 9000007.
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      246. Nicolaou K, Guy RK, Potier P. Taxoids: new weapons against cancer. Sci Am. 1996 Jun; 274(6):94-8. PMID: 8643952.
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      247. Smith AL, Nicolaou K. The enediyne antibiotics. J Med Chem. 1996 May 24; 39(11):2103-17. PMID: 8667354.
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      248. Liu C, Smith BM, Ajito K, Komatsu H, Gomez-Paloma L, Li T, Theodorakis EA, Nicolaou K, Vogt PK. Sequence-selective carbohydrate-DNA interaction: dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function. Proc Natl Acad Sci U S A. 1996 Jan 23; 93(2):940-4. PMID: 8570664.
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      249. Koide K, Bunnage ME, Gomez Paloma L, Kanter JR, Taylor SS, Brunton LL, Nicolaou K. Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. Chem Biol. 1995 Sep; 2(9):601-8. PMID: 9383464.
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      250. Gawley RE, Rein KS, Jeglitsch G, Adams DJ, Theodorakis EA, Tiebes J, Nicolaou K, Baden DG. The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels. Chem Biol. 1995 Aug; 2(8):533-41. PMID: 9383457.
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      251. Chakraborty TK, Weber HP, Nicolaou K. Design and synthesis of a rapamycin-based high affinity binding FKBP12 ligand. Chem Biol. 1995 Mar; 2(3):157-61. PMID: 9383417.
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      252. Wrasidlo W, Hiatt A, Mauch S, Merlock RA, Nicolaou K. In vivo efficacy of novel synthetic enediynes 1. Acta Oncol. 1995; 34(2):157-64. PMID: 7718252.
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      253. Gomez Paloma L, Guy RK, Wrasidlo W, Nicolaou K. Conformation of a water-soluble derivative of taxol in water by 2D-NMR spectroscopy. Chem Biol. 1994 Oct; 1(2):107-12. PMID: 9383378.
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      254. Nicolaou K, Pitsinos EN, Theodorakis EA, Saimoto H, Wrasidlo W. Synthetic calicheamicin mimics with novel initiation mechanisms: DNA cleavage, cytotoxicity, and apoptosis. Chem Biol. 1994 Sep; 1(1):57-66. PMID: 9383371.
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      255. Corbeil J, Richman DD, Wrasidlo W, Nicolaou K, Looney DJ. Antiproliferative effects of enediynes on AIDS-derived Kaposi's sarcoma cells. Cancer Res. 1994 Aug 15; 54(16):4270-3. PMID: 8044770.
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      256. Li T, Nicolaou K. Chemical self-replication of palindromic duplex DNA. Nature. 1994 May 19; 369(6477):218-21. PMID: 8183341.
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      257. Nicolaou K, Yang Z, Liu JJ, Ueno H, Nantermet PG, Guy RK, Claiborne CF, Renaud J, Couladouros EA, Paulvannan K. Total synthesis of taxol. Nature. 1994 Feb 17; 367(6464):630-4. PMID: 7906395.
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      258. Maryanoff BE, Qiu X, Padmanabhan KP, Tulinsky A, Almond HR, Andrade-Gordon P, Greco MN, Kauffman JA, Nicolaou K, Liu A. Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A. Proc Natl Acad Sci U S A. 1993 Sep 1; 90(17):8048-52. PMID: 8367461.
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      259. Nicolaou K, Riemer C, Kerr MA, Rideout D, Wrasidlo W. Design, synthesis and biological activity of protaxols. Nature. 1993 Jul 29; 364(6436):464-6. PMID: 8101355.
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      260. Nicolaou K, Smith AL, Yue EW. Chemistry and biology of natural and designed enediynes. Proc Natl Acad Sci U S A. 1993 Jul 1; 90(13):5881-8. PMID: 8327459.
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      261. Nicolaou K, Stabila P, Esmaeli-Azad B, Wrasidlo W, Hiatt A. Cell-specific regulation of apoptosis by designed enediynes. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3142-6. PMID: 8475052.
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      262. Nicolaou K, Dai WM, Tsay SC, Estevez VA, Wrasidlo W. Designed enediynes: a new class of DNA-cleaving molecules with potent and selective anticancer activity. Science. 1992 May 22; 256(5060):1172-8. PMID: 1589797.
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      263. Nicolaou K, Caulfield TJ, Katoaka H. Total synthesis of globotriaosylceramide (Gb3) and lysoglobotriaosylceramide (lysoGb3). Carbohydr Res. 1990 Jul 15; 202:177-91. PMID: 2224889.
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      264. Nicolaou K, Ladduwahetty T, Randall JL, Chucholowski A. Stereospecific 1,2-migrations in carbohydrates. Stereocontrolled synthesis of .alpha.- and .beta.-2-deoxyglycosides. J Am Chem Soc. 1986 Apr 1; 108(9):2466-7. PMID: 22175613.
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      265. Nicolaou K, Duggan ME, Hwang CK. New synthetic technology for the construction of oxocenes. J Am Chem Soc. 1986 Apr 1; 108(9):2468-9. PMID: 22175614.
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      266. Koshishara Y, Murota S, Petasis NA, Nicolaou K. Selective inhibition of 5-lipoxygenase by 5,6-methanoleukotriene A4, a stable analogue of leukotriene A4. FEBS Lett. 1982 Jun 21; 143(1):13-6. PMID: 6811315.
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      267. Nicolaou K, Barnette WE, Gasic GP, Magolda RL. 6,9-thiaprostacyclin. A stable and biologically potent analogue of prostacyclin (PGI2) J Am Chem Soc. 1977 Nov 9; 99(23):7736-8. PMID: 334822.
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      268. Corey EJ, Nicolaou K, Toru T. Letter: Total synthesis of (plus or minus)-vermiculine. J Am Chem Soc. 1975 Apr 16; 97(8):2287-8. PMID: 1133413.
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      269. Cory EJ, Nicolaou K, Melvin LS. Letter: Synthesis of novel macrocyclic lactones in the prostaglandin and polyether antibiotic series. J Am Chem Soc. 1975 Feb 5; 97(3):653-4. PMID: 1133366.
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