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William Wachsman

Title(s)Professor Of Clinical, Medicine
SchoolHealth Sciences
Phone858-552-8585
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    AIDS-RELATED MALIGNANCIES CONSORTIUM--UC SAN DIEGO
    NIH/NCI U01CA083035Sep 22, 1999 - Aug 31, 2006
    Role: Principal Investigator
    TAX RESPONSE COMPLEX-1 AND HTLV PATHOGENESIS
    NIH/NCI R01CA059713Feb 18, 1994 - Jan 31, 1998
    Role: Principal Investigator
    MOLECULAR STUDIES ON HTLV X GENE PRODUCT/LTR INTERACTION
    NIH/NCI K08CA001113Jul 1, 1986 - Nov 30, 1989
    Role: Principal Investigator
    HUMAN RETROVIRUSES AND HAIRY-CELL LEUKEMIA
    NIH/NCI R01CA043370Jul 1, 1986 - Jun 30, 1989
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Reid EG, Looney D, Maldarelli F, Noy A, Henry D, Aboulafia D, Ramos JC, Sparano J, Ambinder RF, Lee J, Cesarman E, Yahyaei S, Mitsuyasu R, Wachsman W. Safety and efficacy of an oncolytic viral strategy using bortezomib with ICE/R in relapsed/refractory HIV-positive lymphomas. Blood Adv. 2018 Dec 26; 2(24):3618-3626. PMID: 30573564.
      View in: PubMed
    2. Sparano JA, Lee JY, Palefsky J, Henry DH, Wachsman W, Rajdev L, Aboulafia D, Ratner L, Fitzgerald TJ, Kachnic L, Mitsuyasu R. Cetuximab Plus Chemoradiotherapy for HIV-Associated Anal Carcinoma: A Phase II AIDS Malignancy Consortium Trial. J Clin Oncol. 2017 Mar; 35(7):727-733. PMID: 27937092.
      View in: PubMed
    3. Noy A, Lensing SY, Moore PC, Gupta N, Aboulafia D, Ambinder R, Baiocchi R, Dezube BJ, Henry D, Kaplan L, Levine AM, Mitsuyasu R, Ratner L, Reid E, Remick S, Sparano J, Tzachanis D, Wachsman W, Chadburn A. Plasmablastic lymphoma is treatable in the HAART era. A 10 year retrospective by the AIDS Malignancy Consortium. Leuk Lymphoma. 2016 07; 57(7):1731-4. PMID: 26674561.
      View in: PubMed
    4. Wachsman W, Morhenn V, Palmer T, Walls L, Hata T, Zalla J, Scheinberg R, Sofen H, Mraz S, Gross K, Rabinovitz H, Polsky D, Chang S. Noninvasive genomic detection of melanoma. Br J Dermatol. 2011 Apr; 164(4):797-806. PMID: 21294715; PMCID: PMC3118279.
      View in: PubMed, PubMed Central
    5. Chiao EY, Dezube BJ, Krown SE, Wachsman W, Brock MV, Giordano TP, Mitsuyasu R, Pantanowitz L. Time for oncologists to opt in for routine opt-out HIV testing? JAMA. 2010 Jul 21; 304(3):334-9. PMID: 20639567; PMCID: PMC3160789.
      View in: PubMed, PubMed Central
    6. Sparano JA, Lee JY, Kaplan LD, Levine AM, Ramos JC, Ambinder RF, Wachsman W, Aboulafia D, Noy A, Henry DH, Von Roenn J, Dezube BJ, Remick SC, Shah MH, Leichman L, Ratner L, Cesarman E, Chadburn A, Mitsuyasu R. Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated B-cell non-Hodgkin lymphoma. Blood. 2010 Apr 15; 115(15):3008-16. PMID: 20023215; PMCID: PMC2858478.
      View in: PubMed, PubMed Central
    7. Lechowicz M, Dittmer DP, Lee JY, Krown SE, Wachsman W, Aboulafia D, Dezube BJ, Ratner L, Said J, Ambinder RF. Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid. Clin Infect Dis. 2009 Dec 15; 49(12):1946-9. PMID: 19911999; PMCID: PMC2952388.
      View in: PubMed, PubMed Central
    8. Spitzer TR, Ambinder RF, Lee JY, Kaplan LD, Wachsman W, Straus DJ, Aboulafia DM, Scadden DT. Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020. Biol Blood Marrow Transplant. 2008 Jan; 14(1):59-66. PMID: 18158962; PMCID: PMC4524737.
      View in: PubMed, PubMed Central
    9. Finnegan DP, Kettle P, Drake M, Matthews C, Alexander HD, Popat R, Cavanagh JD, Wachsman W, Morris TC. Bortezomib is effective in primary plasma cell leukemia. Leuk Lymphoma. 2006 Aug; 47(8):1670-3. PMID: 16966282.
      View in: PubMed
    10. Tsukasaki K, Tanosaki S, DeVos S, Hofmann WK, Wachsman W, Gombart AF, Krebs J, Jauch A, Bartram CR, Nagai K, Tomonaga M, Said JW, Koeffler HP. Identifying progression-associated genes in adult T-cell leukemia/lymphoma by using oligonucleotide microarrays. Int J Cancer. 2004 May 10; 109(6):875-81. PMID: 15027121.
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    11. Stuart RO, Wachsman W, Berry CC, Wang-Rodriguez J, Wasserman L, Klacansky I, Masys D, Arden K, Goodison S, McClelland M, Wang Y, Sawyers A, Kalcheva I, Tarin D, Mercola D. In silico dissection of cell-type-associated patterns of gene expression in prostate cancer. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):615-20. PMID: 14722351; PMCID: PMC327196.
      View in: PubMed, PubMed Central
    12. de Vos S, Krug U, Hofmann WK, Pinkus GS, Swerdlow SH, Wachsman W, Grogan TM, Said JW, Koeffler HP. Cell cycle alterations in the blastoid variant of mantle cell lymphoma (MCL-BV) as detected by gene expression profiling of mantle cell lymphoma (MCL) and MCL-BV. Diagn Mol Pathol. 2003 Mar; 12(1):35-43. PMID: 12605034.
      View in: PubMed
    13. de Vos S, Hofmann WK, Grogan TM, Krug U, Schrage M, Miller TP, Braun JG, Wachsman W, Koeffler HP, Said JW. Gene expression profile of serial samples of transformed B-cell lymphomas. Lab Invest. 2003 Feb; 83(2):271-85. PMID: 12594241.
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    14. Hofmann WK, de Vos S, Komor M, Hoelzer D, Wachsman W, Koeffler HP. Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow. Blood. 2002 Nov 15; 100(10):3553-60. PMID: 12411319.
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    15. Bower KE, Zeller RW, Wachsman W, Martinez T, McGuire KL. Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions. J Biol Chem. 2002 Sep 20; 277(38):34967-77. PMID: 12087103.
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    16. Qiao J, Bush KT, Steer DL, Stuart RO, Sakurai H, Wachsman W, Nigam SK. Multiple fibroblast growth factors support growth of the ureteric bud but have different effects on branching morphogenesis. Mech Dev. 2001 Dec; 109(2):123-35. PMID: 11731227.
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    17. Hofmann WK, de Vos S, Tsukasaki K, Wachsman W, Pinkus GS, Said JW, Koeffler HP. Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray. Blood. 2001 Aug 01; 98(3):787-94. PMID: 11468180.
      View in: PubMed
    18. Iacobelli M, Wachsman W, McGuire KL. Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein. J Immunol. 2000 Jul 15; 165(2):860-8. PMID: 10878360.
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    19. Palmer DL, Hjelle BL, Wiley CA, Allen S, Wachsman W, Mills RG, Davis LE, Merlin TL. HIV-1 infection despite immediate combination antiviral therapy after infusion of contaminated white cells. Am J Med. 1994 Sep; 97(3):289-95. PMID: 8092178.
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    20. Broor S, Kusari AB, Zhang B, Seth P, Richman DD, Carson DA, Wachsman W, Lotz M. Stimulation of HIV replication in mononuclear phagocytes by leukemia inhibitory factor. J Acquir Immune Defic Syndr. 1994 Jul; 7(7):647-54. PMID: 8207643.
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    21. Brandt DW, Wachsman W, Deftos LJ. Parathyroid hormone-like protein: alternative messenger RNA splicing pathways in human cancer cell lines. Cancer Res. 1994 Feb 01; 54(3):850-3. PMID: 8306349.
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    22. Feuer G, Zack JA, Harrington WJ, Valderama R, Rosenblatt JD, Wachsman W, Baird SM, Chen IS. Establishment of human T-cell leukemia virus type I T-cell lymphomas in severe combined immunodeficient mice. Blood. 1993 Aug 01; 82(3):722-31. PMID: 8338942.
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    23. Dickoff DJ, Simpson DM, Wiley CA, Mendelson SG, Farraye J, Wolfe DE, Wachsman W. HTLV-1 in acquired adult myopathy. Muscle Nerve. 1993 Feb; 16(2):162-5. PMID: 8429839.
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    24. Bhigjee AI, Bill PL, Wiley CA, Windsor IM, Matthias DA, Amenomori T, Wachsman W, Moorhouse D. Peripheral nerve lesions in HTLV-I associated myelopathy (HAM/TSP). Muscle Nerve. 1993 Jan; 16(1):21-6. PMID: 8380901.
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    25. Davis LE, Hjelle BL, Miller VE, Palmer DL, Llewellyn AL, Merlin TL, Young SA, Mills RG, Wachsman W, Wiley CA. Early viral brain invasion in iatrogenic human immunodeficiency virus infection. Neurology. 1992 Sep; 42(9):1736-9. PMID: 1513462.
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    26. Bhigjee AI, Wiley CA, Wachsman W, Amenomori T, Pirie D, Bill PL, Windsor I. HTLV-I-associated myelopathy: clinicopathologic correlation with localization of provirus to spinal cord. Neurology. 1991 Dec; 41(12):1990-2. PMID: 1745362.
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    27. Kekow J, Wachsman W, McCutchan JA, Gross WL, Zachariah M, Carson DA, Lotz M. Transforming growth factor-beta and suppression of humoral immune responses in HIV infection. J Clin Invest. 1991 Mar; 87(3):1010-6. PMID: 1999481.
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    28. Villiger PM, Cronin MT, Amenomori T, Wachsman W, Lotz M. IL-6 production by human T lymphocytes. Expression in HTLV-1-infected but not in normal T cells. J Immunol. 1991 Jan 15; 146(2):550-9. PMID: 1987276.
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    29. Kekow J, Wachsman W, McCutchan JA, Cronin M, Carson DA, Lotz M. Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8321-5. PMID: 1700428.
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    30. Nyborg JK, Matthews MA, Yucel J, Walls L, Golde WT, Dynan WS, Wachsman W. Interaction of host cell proteins with the human T-cell leukemia virus type I transcriptional control region. II. A comprehensive map of protein-binding sites facilitates construction of a simple chimeric promoter responsive to the viral tax2 gene product. J Biol Chem. 1990 May 15; 265(14):8237-42. PMID: 2186038.
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    31. Cann AJ, Rosenblatt JD, Wachsman W, Chen IS. In vitro mutagenesis of the human T-cell leukemia virus types I and II tax genes. J Virol. 1989 Mar; 63(3):1474-9. PMID: 2783740.
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    32. Rosenblatt JD, Chen IS, Wachsman W. Infection with HTLV-I and HTLV-II: evolving concepts. Semin Hematol. 1988 Jul; 25(3):230-46. PMID: 2900553.
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    33. Rosenblatt JD, Cann AJ, Slamon DJ, Smalberg IS, Shah NP, Fujii J, Wachsman W, Chen IS. HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes. Science. 1988 May 13; 240(4854):916-9. PMID: 2834826.
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    34. Nimer SD, Morita EA, Martis MJ, Wachsman W, Gasson JC. Characterization of the human granulocyte-macrophage colony-stimulating factor promoter region by genetic analysis: correlation with DNase I footprinting. Mol Cell Biol. 1988 May; 8(5):1979-84. PMID: 2838738.
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    35. Nyborg JK, Dynan WS, Chen IS, Wachsman W. Binding of host-cell factors to DNA sequences in the long terminal repeat of human T-cell leukemia virus type I: implications for viral gene expression. Proc Natl Acad Sci U S A. 1988 Mar; 85(5):1457-61. PMID: 2830620.
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    36. Rosenblatt JD, Giorgi JV, Golde DW, Ezra JB, Wu A, Winberg CD, Glaspy J, Wachsman W, Chen IS. Integrated human T-cell leukemia virus II genome in CD8 + T cells from a patient with "atypical" hairy cell leukemia: evidence for distinct T and B cell lymphoproliferative disorders. Blood. 1988 Feb; 71(2):363-9. PMID: 2827811.
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    37. Wachsman W, Cann AJ, Williams JL, Slamon DJ, Souza L, Shah NP, Chen IS. HTLV x gene mutants exhibit novel transcriptional regulatory phenotypes. Science. 1987 Feb 06; 235(4789):674-7. PMID: 3027894.
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    38. Shah NP, Wachsman W, Cann AJ, Souza L, Slamon DJ, Chen IS. Comparison of the trans-activation capabilities of the human T-cell leukemia virus type I and II chi proteins. Mol Cell Biol. 1986 Nov; 6(11):3626-31. PMID: 3025604; PMCID: PMC367123.
      View in: PubMed, PubMed Central
    39. Wachsman W, Golde DW, Chen IS. HTLV and human leukemia: perspectives 1986. Semin Hematol. 1986 Oct; 23(4):245-56. PMID: 2877495.
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    40. Rosenblatt JD, Golde DW, Wachsman W, Giorgi JV, Jacobs A, Schmidt GM, Quan S, Gasson JC, Chen IS. A second isolate of HTLV-II associated with atypical hairy-cell leukemia. N Engl J Med. 1986 Aug 07; 315(6):372-7. PMID: 3016537.
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    41. Chen IS, Wachsman W, Rosenblatt JD, Cann AJ. The role of the x gene in HTLV associated malignancy. Cancer Surv. 1986; 5(2):329-42. PMID: 2877734.
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    42. Cann AJ, Rosenblatt JD, Wachsman W, Shah NP, Chen IS. Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation. Nature. 1985 Dec 12-18; 318(6046):571-4. PMID: 2999613.
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    43. Wachsman W, Slamon D, Shimotohno K, Golde DW, Chen IS. Human T-cell leukemia virus x gene. Cancer Res. 1985 Sep; 45(9 Suppl):4550s-4552s. PMID: 2990685.
      View in: PubMed
    44. Chen IS, Slamon DJ, Rosenblatt JD, Shah NP, Quan SG, Wachsman W. The x gene is essential for HTLV replication. Science. 1985 Jul 05; 229(4708):54-8. PMID: 2990037.
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    45. Wachsman W, Golde DW, Temple PA, Orr EC, Clark SC, Chen IS. HTLV x-gene product: requirement for the env methionine initiation codon. Science. 1985 Jun 28; 228(4707):1534-7. PMID: 2990032.
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    46. Wachsman W, Golde DW, Chen IS. Hairy cell leukemia and human T cell leukemia virus. Semin Oncol. 1984 Dec; 11(4):446-50. PMID: 6095456.
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    47. Shimotohno K, Wachsman W, Takahashi Y, Golde DW, Miwa M, Sugimura T, Chen IS. Nucleotide sequence of the 3' region of an infectious human T-cell leukemia virus type II genome. Proc Natl Acad Sci U S A. 1984 Nov; 81(21):6657-61. PMID: 6093110.
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    48. Wachsman W, Shimotohno K, Clark SC, Golde DW, Chen IS. Expression of the 3' terminal region of human T-cell leukemia viruses. Science. 1984 Oct 12; 226(4671):177-9. PMID: 6091270.
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    49. Rosenblatt J, Wachsman W, Shimotohno K, Slamon D, Chen IS. The comparative molecular biology of HTLV-I and HTLV-II. Princess Takamatsu Symp. 1984; 15:177-85. PMID: 6100637.
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    50. Ascensao JL, Flynn PJ, Slungaard A, Wachsman W, Zanjani ED, Jacob HS. Quinidine-induced neutropenia: report of a case with drug-dependent inhibition of granulocyte colony generation. Acta Haematol. 1984; 72(5):349-54. PMID: 6441417.
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    51. Miller WJ, Branda RF, Hurd DD, Wachsman W, Nelson NL, Jacob HS. Protein A adsorption of acute myelogenous leukemia serum induces in vitro blast lysis. Blood. 1982 Jun; 59(6):1344-7. PMID: 7044448.
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    52. Wachsman W, Anthony DD. Conformational changes in deoxyribonucleic acid during transcription. Biochemistry. 1980 Dec 23; 19(26):5981-6. PMID: 7193479.
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