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David Janowsky

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentPsychiatry
Address9500 Gilman Drive #0603
La Jolla CA 92093
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    Biography

    David S. Janowsky M.D. received his B.S. and M.D. degrees from the University of California, San Francisco and completed his psychiatry residency at the University of California, Los Angeles and at the intramural program at the National Institutes of Mental Health in Bethesda, Maryland, where he was a US Public Health Service officer. He has held faculty positions at UCSD, UCLA, Vanderbilt University, and the University of North Carolina (UNC), Chapel Hill. He is a past Chair of of the Department of Psychiatry at UNC and a past Director of the Center for Alcohol Studies at that institution. Dr Janowsky is currently a Clinical Professor of Psychiatry at UCSD and the Associate Director of Outpatient Psychiatric Services (OPS). He is known for his expertise in the study and pharmacological and psychological treatment of bipolar and related affective disorders. Dr. Janowsky was previously the director of the UCSD Affective Disorders Mental Health Clinical Research Center. His research has focused primarily on the psychobiology of affective disorders and schizophrenia, the psychobiology of ovarian hormone linked emotional disorders, the relationship of core personality and temperament to psychiatric diagnosis and outcome, and the development of anti-craving drugs using animal models of alcoholism.


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    Collapse Research Activities and Funding
    PHYSICIAN DEVELOPMENT IN ALCOHOL AND OTHER DRUG ABUSE
    NIH/NIAAA T01AA007482Sep 29, 1989 - Aug 31, 1994
    Role: Principal Investigator
    ASIP--UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    NIH/NIMH S15MH045866Sep 1, 1989 - Aug 31, 1990
    Role: Principal Investigator
    PSYCHOBIOLOGICAL STUDY OF PSYCHIATRIC DISORDERS
    NIH/NIMH P50MH030914Sep 29, 1977 - Feb 28, 1997
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. van Enkhuizen J, Janowsky D, Olivier B, Minassian A, Perry W, Young JW, Geyer MA. The catecholaminergic-cholinergic balance hypothesis of bipolar disorder revisited. Eur J Pharmacol. 2015 Apr 15; 753:114-26. PMID: 25107282; PMCID: PMC4318788.
    2. Janowsky D, Buneviciute J, Hu Q, Davis JM. Lithium-induced renal insufficiency: a longitudinal study of creatinine increases in intellectually disabled adults. J Clin Psychopharmacol. 2011 Dec; 31(6):769-73. PMID: 22020353.
      View in: PubMed
    3. Janowsky D. Serendipity strikes again: scopolamine as an antidepressant agent in bipolar depressed patients. Curr Psychiatry Rep. 2011 Dec; 13(6):443-5. PMID: 21976067.
      View in: PubMed
    4. Janowsky D, Hu Q, Buneviciute J, Davis JM. Minimum effective and relapse-associated doses of risperidone and olanzapine in aggressive, intellectually disabled adults. J Clin Psychopharmacol. 2011 Apr; 31(2):238-40. PMID: 21364333.
      View in: PubMed
    5. Janowsky D. Bipolar disorder- and major depression-relevant abstracts from the 2009 9th World Congress of Biological Psychiatry Meeting. Curr Psychiatry Rep. 2009 Dec; 11(6):509-11. PMID: 19909675.
      View in: PubMed
    6. Janowsky D, Soares J, Hatch JP, Zunta-Soares G, Hu Q, Davis JM. Lithium effect on renal glomerular function in individuals with intellectual disability. J Clin Psychopharmacol. 2009 Jun; 29(3):296-9. PMID: 19440087.
      View in: PubMed
    7. Janowsky D, Davis JM. Antipsychotic properties of muscarinic drugs. Am J Psychiatry. 2009 Jan; 166(1):110; author reply 110-1. PMID: 19122017.
      View in: PubMed
    8. Janowsky D. Bipolar disorder-relevant abstracts of posters from the 2008 CINP congress. Curr Psychiatry Rep. 2008 Dec; 10(6):525-7. PMID: 18980737.
      View in: PubMed
    9. Janowsky D, Barnhill LJ, Khalid AS, Davis JM. Antipsychotic withdrawal-induced relapse predicts future relapses in institutionalized adults with severe intellectual disability. J Clin Psychopharmacol. 2008 Aug; 28(4):401-5. PMID: 18626266.
      View in: PubMed
    10. Janowsky D. Scopolamine as an antidepressant agent: theoretical and treatment considerations. Curr Psychiatry Rep. 2007 Dec; 9(6):447-8. PMID: 18221623.
      View in: PubMed
    11. Janowsky D. Recent depression updates: relevant presentations. Curr Psychiatry Rep. 2006 Dec; 8(6):470-2. PMID: 17094926.
      View in: PubMed
    12. Janowsky D, Barnhill LJ, Khalid AS, Davis JM. Relapse of aggressive and disruptive behavior in mentally retarded adults following antipsychotic drug withdrawal predicts psychotropic drug use a decade later. J Clin Psychiatry. 2006 Aug; 67(8):1272-7. PMID: 16965207.
      View in: PubMed
    13. Janowsky D. Current issues in the treatment of depression in bipolar disorder patients. Curr Psychiatry Rep. 2005 Dec; 7(6):485-6. PMID: 16318828.
      View in: PubMed
    14. Janowsky D, Davis JM. Diagnosis and treatment of depression in patients with mental retardation. Curr Psychiatry Rep. 2005 Dec; 7(6):421-8. PMID: 16318819.
      View in: PubMed
    15. Janowsky D, Davis JM, Overstreet DH. Anticholinesterase (DFP) toxicity antagonism by chronic donepezil: a potential nerve agent treatment. Pharmacol Biochem Behav. 2005 Aug; 81(4):917-22. PMID: 16054679.
      View in: PubMed
    16. Janowsky D, Barnhill LJ, Shetty M, Davis JM. Minimally effective doses of conventional antipsychotic medications used to treat aggression, self-injurious and destructive behaviors in mentally retarded adults. J Clin Psychopharmacol. 2005 Feb; 25(1):19-25. PMID: 15643096.
      View in: PubMed
    17. Janowsky D. Issues of functionality in bipolar disorders. Curr Psychiatry Rep. 2004 Dec; 6(6):449-50. PMID: 15538993.
      View in: PubMed
    18. Janowsky D, Shetty M, Barnhill J, Elamir B, Davis JM. Serotonergic antidepressant effects on aggressive, self-injurious and destructive/disruptive behaviours in intellectually disabled adults: a retrospective, open-label, naturalistic trial. Int J Neuropsychopharmacol. 2005 Mar; 8(1):37-48. PMID: 15482629.
      View in: PubMed
    19. Janowsky D, Davis JM, Overstreet DH. Antagonism of anticholinesterase (DFP) toxicity by donepezil plus scopolamine: a preliminary study. Pharmacol Biochem Behav. 2004 Feb; 77(2):337-43. PMID: 14751462.
      View in: PubMed
    20. Janowsky D. Depression and dysphoria effects on the interpersonal perception of negative and positive moods and caring relationships: effects of antidepressants, amphetamine, and methylphenidate. Curr Psychiatry Rep. 2003 Dec; 5(6):451-9. PMID: 14609500.
      View in: PubMed
    21. Janowsky D, Kraus JE, Barnhill J, Elamir B, Davis JM. Effects of topiramate on aggressive, self-injurious, and disruptive/destructive behaviors in the intellectually disabled: an open-label retrospective study. J Clin Psychopharmacol. 2003 Oct; 23(5):500-4. PMID: 14520128.
      View in: PubMed
    22. Janowsky D, Barnhill LJ, Davis JM. Olanzapine for self-injurious, aggressive, and disruptive behaviors in intellectually disabled adults: a retrospective, open-label, naturalistic trial. J Clin Psychiatry. 2003 Oct; 64(10):1258-65. PMID: 14658977.
      View in: PubMed
    23. Overstreet DH, Daws LC, Yadid G, Friedman E, Mathé AA, Janowsky D. Comment on "preclinical models: status of basic research in depression". Biol Psychiatry. 2003 Feb 01; 53(3):268-70; author reply 270. PMID: 12559663.
      View in: PubMed
    24. Janowsky D, Pucilowski O, Buyinza M. Preference for higher sucrose concentrations in cocaine abusing-dependent patients. J Psychiatr Res. 2003 Jan-Feb; 37(1):35-41. PMID: 12482468.
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    25. Janowsky D, Rausch JL, Davis JM. Historical studies of premenstrual tension up to 30 years ago: implications for future research. Curr Psychiatry Rep. 2002 Dec; 4(6):411-8. PMID: 12441020.
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    26. Janowsky D, Hong E, Morter S, Howe L. Myers Briggs Type indicator personality profiles in unipolar depressed patients. World J Biol Psychiatry. 2002 Oct; 3(4):207-15. PMID: 12516312.
      View in: PubMed
    27. Janowsky D. Central anticholinergics to treat nerve-agent poisoning. Lancet. 2002 Jan 19; 359(9302):265-6. PMID: 11812600.
      View in: PubMed
    28. Janowsky D, Morter S, Hong L. Relationship of Myers Briggs type indicator personality characteristics to suicidality in affective disorder patients. J Psychiatr Res. 2002 Jan-Feb; 36(1):33-9. PMID: 11755459.
      View in: PubMed
    29. Janowsky D. Introversion and extroversion: implications for depression and suicidality. Curr Psychiatry Rep. 2001 Dec; 3(6):444-50. PMID: 11707157.
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    30. Glick ID, Janowsky D, Zisook S. On Using the ASCP Model Curriculum for Psychopharmacology:Comments and an Update. Acad Psychiatry. 2001 Dec; 25(4):237-238. PMID: 11744542.
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    31. Janowsky D, Fawcett J, Meszaros K, Verheul R. Core heritable personality characteristics and relapse in alcoholics. Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):94S-98S. PMID: 11391056.
      View in: PubMed
    32. Janowsky D, Morter S, Tancer M. Over-representation of Myers Briggs Type Indicator introversion in social phobia patients. Depress Anxiety. 2000; 11(3):121-5. PMID: 10875053.
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    33. Rezvani AH, Overstreet DH, Mason GA, Janowsky D, Hamedi M, Clark E, Yang Y. Combination pharmacotherapy: a mixture of small doses of naltrexone, fluoxetine, and a thyrotropin-releasing hormone analogue reduces alcohol intake in three strains of alcohol-preferring rats. Alcohol Alcohol. 2000 Jan; 35(1):76-83. PMID: 10684782.
      View in: PubMed
    34. Janowsky D, Morter S, Hong L, Howe L. Myers Briggs Type Indicator and Tridimensional Personality Questionnaire differences between bipolar patients and unipolar depressed patients. Bipolar Disord. 1999 Dec; 1(2):98-108. PMID: 11252666.
      View in: PubMed
    35. Janowsky D. New treatments of bipolar disorder. Curr Psychiatry Rep. 1999 Dec; 1(2):111-3. PMID: 11122912.
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    36. Janowsky D, Hong L, Morter S, Howe L. Underlying personality differences between alcohol/substance-use disorder patients with and without an affective disorder. Alcohol Alcohol. 1999 May-Jun; 34(3):370-7. PMID: 10414613.
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    37. Kampov-Polevoy AB, Garbutt JC, Janowsky D. Association between preference for sweets and excessive alcohol intake: a review of animal and human studies. Alcohol Alcohol. 1999 May-Jun; 34(3):386-95. PMID: 10414615.
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    38. Janowsky D, Boone A, Morter S, Howe L. Personality and alcohol/substance-use disorder patient relapse and attendance at self-help group meetings. Alcohol Alcohol. 1999 May-Jun; 34(3):359-69. PMID: 10414612.
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    39. Janowsky D. Introduction to personality-biological interactions in alcoholism: 'The Markku Linnoila Memorial Symposium'. Alcohol Alcohol. 1999 May-Jun; 34(3):357-8. PMID: 10414611.
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    40. Tizabi Y, Overstreet DH, Rezvani AH, Louis VA, Clark E, Janowsky D, Kling MA. Antidepressant effects of nicotine in an animal model of depression. Psychopharmacology (Berl). 1999 Feb; 142(2):193-9. PMID: 10102772.
      View in: PubMed
    41. Kampov-Polevoy AB, Garbutt JC, Davis CE, Janowsky D. Preference for higher sugar concentrations and Tridimensional Personality Questionnaire scores in alcoholic and nonalcoholic men. Alcohol Clin Exp Res. 1998 May; 22(3):610-4. PMID: 9622439.
      View in: PubMed
    42. Overstreet DH, Daws LC, Schiller GD, Orbach J, Janowsky D. Cholinergic/serotonergic interactions in hypothermia: implications for rat models of depression. Pharmacol Biochem Behav. 1998 Apr; 59(4):777-85. PMID: 9586831.
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    43. Kampov-Polevoy A, Garbutt JC, Janowsky D. Evidence of preference for a high-concentration sucrose solution in alcoholic men. Am J Psychiatry. 1997 Feb; 154(2):269-70. PMID: 9016281.
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    44. Overstreet DH, Miller CS, Janowsky D, Russell RW. Potential animal model of multiple chemical sensitivity with cholinergic supersensitivity. Toxicology. 1996 Jul 17; 111(1-3):119-34. PMID: 8711728.
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    45. Overstreet DH, Lee YW, Rezvani AH, Pei YH, Criswell HE, Janowsky D. Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives. Alcohol Clin Exp Res. 1996 Apr; 20(2):221-7. PMID: 8730211.
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    46. Overstreet DH, Rezvani AH, Knapp DJ, Crews FT, Janowsky D. Further selection of rat lines differing in 5-HT-1A receptor sensitivity: behavioral and functional correlates. Psychiatr Genet. 1996; 6(3):107-17. PMID: 8902886.
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    47. Kampov-Polevoy AB, Overstreet DH, Rezvani AH, Janowsky D. Suppression of ethanol intake in alcohol-preferring rats by prior voluntary saccharin consumption. Pharmacol Biochem Behav. 1995 Sep; 52(1):59-64. PMID: 7501679.
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    48. Overstreet DH, Pucilowski O, Rezvani AH, Janowsky D. Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression. Psychopharmacology (Berl). 1995 Sep; 121(1):27-37. PMID: 8539339.
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    49. Kampov-Polevoy AB, Overstreet DH, Rezvani AH, Janowsky D. Saccharin-induced increase in daily fluid intake as a predictor of voluntary alcohol intake in alcohol-preferring rats. Physiol Behav. 1995 Apr; 57(4):791-5. PMID: 7777619.
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    50. Ayensu WK, Pucilowski O, Mason GA, Overstreet DH, Rezvani AH, Janowsky D. Effects of chronic mild stress on serum complement activity, saccharin preference, and corticosterone levels in Flinders lines of rats. Physiol Behav. 1995 Jan; 57(1):165-9. PMID: 7878112.
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    51. Janowsky D, Overstreet DH, Nurnberger JI. Is cholinergic sensitivity a genetic marker for the affective disorders? Am J Med Genet. 1994 Dec 15; 54(4):335-44. PMID: 7726206.
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    52. Pucilowski O, Rezvani AH, Overstreet DH, Janowsky D. Calcium channel inhibitors attenuate consumption of ethanol, sucrose and saccharin solutions in rats. Behav Pharmacol. 1994 Aug; 5(4 And 5):494-501. PMID: 11224301.
      View in: PubMed
    53. Overstreet DH, Rezvani AH, Pucilowski O, Gause L, Janowsky D. Rapid selection for serotonin-1A sensitivity in rats. Psychiatr Genet. 1994; 4(1):57-62. PMID: 8049904.
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    54. Overstreet DH, Janowsky D, Pucilowski O, Rezvani AH. Swim test immobility co-segregates with serotonergic but not cholinergic sensitivity in cross-breeds of Flinders Line rats. Psychiatr Genet. 1994; 4(2):101-7. PMID: 8055248.
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    55. Overstreet DH, Rezvani AH, Pucilowski O, Janowsky D. 5-HT receptors: implications for the neuropharmacology of alcohol and alcoholism. Alcohol Alcohol Suppl. 1994; 2:205-10. PMID: 8974337.
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    56. Pucilowski O, Overstreet DH, Rezvani AH, Janowsky D. Chronic mild stress-induced anhedonia: greater effect in a genetic rat model of depression. Physiol Behav. 1993 Dec; 54(6):1215-20. PMID: 8295967.
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    57. Rezvani AH, Pucilowski O, Grady DR, Janowsky D, O'Brien RA. Reduction of spontaneous alcohol drinking and physical withdrawal by levemopamil, a novel Ca2+ channel antagonist, in rats. Pharmacol Biochem Behav. 1993 Oct; 46(2):365-71. PMID: 8265691.
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    58. Pucilowski O, Garges PL, Rezvani AH, Hutheson S, Janowsky D. Verapamil suppresses d-amphetamine-induced place preference conditioning. Eur J Pharmacol. 1993 Aug 10; 240(1):89-92. PMID: 8405127.
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    59. Overstreet DH, Kampov-Polevoy AB, Rezvani AH, Murrelle L, Halikas JA, Janowsky D. Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains. Alcohol Clin Exp Res. 1993 Apr; 17(2):366-9. PMID: 8488981.
      View in: PubMed
    60. Glick ID, Janowsky D, Salzman C, Shader RI. A proposal for a model psychopharmacology curriculum for psychiatric residents. Neuropsychopharmacology. 1993 Jan; 8(1):1-5. PMID: 8424844.
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    61. Overstreet DH, Rezvani AH, Janowsky D. Maudsley reactive and nonreactive rats differ only in some tasks reflecting emotionality. Physiol Behav. 1992 Jul; 52(1):149-52. PMID: 1528998.
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    62. Overstreet DH, Rezvani AH, Janowsky D. Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism. Biol Psychiatry. 1992 May 01; 31(9):919-36. PMID: 1386257.
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    63. Rezvani AH, Garbutt JC, Shimoda K, Garges PL, Janowsky D, Mason GA. Attenuation of alcohol preference in alcohol-preferring rats by a novel TRH analogue, TA-0910. Alcohol Clin Exp Res. 1992 Apr; 16(2):326-30. PMID: 1590553.
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    64. Pucilowski O, Rezvani AH, Janowsky D. Suppression of alcohol and saccharin preference in rats by a novel Ca2+ channel inhibitor, Goe 5438. Psychopharmacology (Berl). 1992; 107(2-3):447-52. PMID: 1615142.
      View in: PubMed
    65. Ayensu WK, Rezvani AH, Overstreet DH, Pucilowski O, Janowsky D. Ethanol and complement hemolytic activity of selectively bred hypercholinergic rats. Alcohol Alcohol. 1992 Jan; 27(1):47-54. PMID: 1580928.
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    66. Caldecott-Hazard S, Morgan DG, DeLeon-Jones F, Overstreet DH, Janowsky D. Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories. Synapse. 1991 Dec; 9(4):251-301. PMID: 1685032.
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    67. Gillin JC, Sutton L, Ruiz C, Darko D, Golshan S, Risch SC, Janowsky D. The effects of scopolamine on sleep and mood in depressed patients with a history of alcoholism and a normal comparison group. Biol Psychiatry. 1991 Jul 15; 30(2):157-69. PMID: 1655072.
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    68. Pucilowski O, Overstreet DH, Rezvani AH, Janowsky D. Effects of calcium channel inhibitors on the hypothermic response to oxotremorine in normo and hypercholinergic rats. J Pharm Pharmacol. 1991 Jun; 43(6):436-9. PMID: 1681059.
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    69. Rapaport MH, Risch SC, Gillin JC, Golshan S, Janowsky D. The effects of physostigmine infusion on patients with panic disorder. Biol Psychiatry. 1991 Apr 01; 29(7):658-64. PMID: 2054436.
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    70. Pucilowski O, Danysz W, Overstreet DH, Rezvani AH, Eichelman B, Janowsky D. Decreased hyperthermic effect of MK-801 in selectively bred hypercholinergic rats. Brain Res Bull. 1991 Apr; 26(4):621-5. PMID: 1868361.
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    71. Gillin JC, Sutton L, Ruiz C, Kelsoe J, Dupont RM, Darko D, Risch SC, Golshan S, Janowsky D. The cholinergic rapid eye movement induction test with arecoline in depression. Arch Gen Psychiatry. 1991 Mar; 48(3):264-70. PMID: 1996921.
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    72. Owens MJ, Overstreet DH, Knight DL, Rezvani AH, Ritchie JC, Bissette G, Janowsky D, Nemeroff CB. Alterations in the hypothalamic-pituitary-adrenal axis in a proposed animal model of depression with genetic muscarinic supersensitivity. Neuropsychopharmacology. 1991 Feb; 4(2):87-93. PMID: 1851013.
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    73. Rezvani AH, Overstreet DH, Janowsky D. Drug-induced reductions in ethanol intake in alcohol preferring and Fawn-Hooded rats. Alcohol Alcohol Suppl. 1991; 1:433-7. PMID: 1845573.
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    74. Pucilowski O, Overstreet DH, Rezvani AH, Janowsky D. Effect of verapamil on submissive behavior in genetically bred hypercholinergic rats in a water competition test. Eur J Pharmacol. 1990 Oct 23; 187(3):507-11. PMID: 2073924.
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    75. Overstreet DH, Dilsaver SC, Janowsky D, Rezvani AH. Effects of bright light on responsiveness to a muscarinic agonist in rats selectively bred for endogenously increased cholinergic function. Psychiatry Res. 1990 Aug; 33(2):139-50. PMID: 2243891.
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    76. Overstreet DH, Rezvani AH, Janowsky D. Impaired active avoidance responding in rats selectively bred for increased cholinergic function. Physiol Behav. 1990 Apr; 47(4):787-8. PMID: 2385654.
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    77. Morrisett RA, Rezvani AH, Overstreet D, Janowsky D, Wilson WA, Swartzwelder HS. MK-801 potently inhibits alcohol withdrawal seizures in rats. Eur J Pharmacol. 1990 Jan 25; 176(1):103-5. PMID: 2155795.
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    78. Overstreet DH, Dilsaver SC, Rezvani AH, Janowsky D. Selective antagonistic effects of exposure to bright light on the hypothermic action of ethanol. Alcohol Alcohol. 1990; 25(6):661-5. PMID: 2085349.
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    79. Rezvani AH, Overstreet DH, Janowsky D. Reduction in ethanol preference following injection of centrally and peripherally acting antimuscarinic agents. Alcohol Alcohol. 1990; 25(1):3-7. PMID: 2334493.
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    80. Overstreet DH, Rezvani AH, Janowsky D. Increased hypothermic responses to ethanol in rats selectively bred for cholinergic supersensitivity. Alcohol Alcohol. 1990; 25(1):59-65. PMID: 2334497.
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    81. Rezvani AH, Mack CM, De Lacy PA, Janowsky D. Verapamil effects on physiological and behavioral responses to ethanol in the rat. Alcohol Alcohol. 1990; 25(1):51-8. PMID: 2334496.
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    82. Rezvani AH, Overstreet DH, Janowsky D. Genetic serotonin deficiency and alcohol preference in the fawn hooded rats. Alcohol Alcohol. 1990; 25(5):573-5. PMID: 2088356.
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    83. Janowsky D, Overstreet DH. Cholinergic dysfunction in depression. Pharmacol Toxicol. 1990; 66 Suppl 3:100-11. PMID: 2179926.
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    84. Pucilowski O, Eichelman B, Overstreet DH, Rezvani AH, Janowsky D. Enhanced affective aggression in genetically bred hypercholinergic rats. Neuropsychobiology. 1990-1991; 24(1):37-41. PMID: 2132639.
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    85. Overstreet DH, Janowsky D, Rezvani AH. Alcoholism and depressive disorders: is cholinergic sensitivity a biological marker? Alcohol Alcohol. 1989; 24(3):253-5. PMID: 2757700.
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    86. Byerley WF, Risch SC, Gillin JC, Janowsky D, Parker D, Rossman LG, Kripke DF. Biological effect of bright light. Prog Neuropsychopharmacol Biol Psychiatry. 1989; 13(5):683-6. PMID: 2550996.
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    87. Rapaport MH, Risch SC, Gillin JC, Golshan S, Janowsky D. Blunted growth hormone response to peripheral infusion of human growth hormone-releasing factor in patients with panic disorder. Am J Psychiatry. 1989 Jan; 146(1):92-5. PMID: 2492166.
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    88. Rausch JL, Janowsky D, Golshan S, Kuhn K, Risch SC. Atenolol treatment of late luteal phase dysphoric disorder. J Affect Disord. 1988 Sep-Oct; 15(2):141-7. PMID: 2975684.
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    89. Overstreet DH, Russell RW, Crocker AD, Gillin JC, Janowsky D. Genetic and pharmacological models of cholinergic supersensitivity and affective disorders. Experientia. 1988 Jun 15; 44(6):465-72. PMID: 3288493.
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    90. Risch SC, Golshan S, Rapaport MH, Dupont R, Outenreath R, Gillin JC, Janowsky D. Neuroendocrine effects of intravenous ovine corticotropin-releasing factor in affective disorder patients and normal controls. Biol Psychiatry. 1988 Apr 01; 23(7):755-8. PMID: 2835998.
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    91. Haggerty JJ, Golden RN, Evans DL, Janowsky D. Differential diagnosis of pseudodementia in the elderly. Geriatrics. 1988 Mar; 43(3):61-9, 72, 74. PMID: 3277890.
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    92. Risch SC, Ehlers C, Janowsky D, Judd L, Gillin JC, Dana R, McAdams LA. Human growth hormone releasing factor infusion effects on plasma growth hormone in affective disorder patients and normal controls. Peptides. 1988; 9 Suppl 1:45-8. PMID: 2856651.
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    93. Janowsky D, Risch SC, Ziegler M, Gillin JC. Antagonistic effects of scopolamine and atropine on the physostigmine response in man. Mil Med. 1987 Nov; 152(11):579-81. PMID: 3122083.
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    94. Risch SC, Janowsky D, Judd LL, Gillin JC, Mott MA, Rausch JL, Huey L. Measurement of ACTH and prolactin in the dexamethasone suppression test. Acta Psychiatr Scand. 1987 Nov; 76(5):535-40. PMID: 2829509.
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    95. Zisook S, Mendels J, Janowsky D, Feighner J, Lee JC, Fritz A. Efficacy and safety of fezolamine in depressed patients. Neuropsychobiology. 1987; 17(3):133-8. PMID: 3683802.
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    96. Rausch JL, Janowsky D, Risch SC, Huey LY. A kinetic analysis and replication of decreased platelet serotonin uptake in depressed patients. Psychiatry Res. 1986 Oct; 19(2):105-12. PMID: 3786602.
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    97. Janowsky D, Risch SC, Ziegler MG, Gillin JC, Huey L, Rausch J. Physostigmine-induced epinephrine release in patients with affective disorder. Am J Psychiatry. 1986 Jul; 143(7):919-21. PMID: 3717437.
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    98. Overstreet DH, Janowsky D, Gillin JC, Shiromani PJ, Sutin EL. Stress-induced immobility in rats with cholinergic supersensitivity. Biol Psychiatry. 1986 Jun; 21(7):657-64. PMID: 3708037.
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    99. Janowsky D, Glick ID, Lash L, Mitnick L, Klein DF, Goodwin FK, Hanin I, Nemeroff C, Robins L. Psychobiology and psychopharmacology: issues in clinical research training. J Clin Psychopharmacol. 1986 Feb; 6(1):1-7. PMID: 3950064.
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    100. Risch SC, Janowsky D, Judd LL, Gillin C, Mott M, Rausch JL, Huey LY. Multiendocrine assessment in the dexamethasone suppression test. Psychopharmacol Bull. 1986; 22(3):913-6. PMID: 3025914.
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    101. Overstreet DH, Booth RA, Dana R, Risch SC, Janowsky D. Enhanced elevation of corticosterone following arecoline administration to rats selectively bred for increased cholinergic function. Psychopharmacology (Berl). 1986; 88(1):129-30. PMID: 3080772.
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    102. Zisook S, Janowsky D, Overall JE, Risch SC. The dexamethasone suppression test and unipolar/bipolar distinctions. J Clin Psychiatry. 1985 Nov; 46(11):461-5. PMID: 4055705.
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    103. Janowsky D, Risch SC, Huey LY, Kennedy B, Ziegler M. Effects of physostigmine on pulse, blood pressure, and serum epinephrine levels. Am J Psychiatry. 1985 Jun; 142(6):738-40. PMID: 4003595.
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    104. Rausch JL, Janowsky D, Risch SC, Huey LY. Physostigmine effects on serotonin uptake in human blood platelets. Eur J Pharmacol. 1985 Feb 12; 109(1):91-6. PMID: 3996470.
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    105. Janowsky D, Berkowitz A, Turken A, Risch SC. Antagonism of physostigmine induced lethality by a combination of scopolamine and methscopolamine. Acta Pharmacol Toxicol (Copenh). 1985 Feb; 56(2):154-7. PMID: 3993383.
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    106. Janowsky D, Rausch J. Biochemical hypotheses of premenstrual tension syndrome. Psychol Med. 1985 Feb; 15(1):3-8. PMID: 2859626.
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    107. Moss DE, Koob GF, McMaster SB, Janowsky D. Comparative effects of tetrahydrocannabinol on psychostimulant-induced behaviors. Pharmacol Biochem Behav. 1984 Oct; 21(4):641-4. PMID: 6150497.
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    108. Janowsky D, Drennan M, Berkowitz A, Turken A, Risch SC. Anticholinergic antagonism of cholinesterase inhibitor lethality. Lancet. 1984 Sep 29; 2(8405):747. PMID: 6148492.
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    109. Risch SC, Janowsky D, Lisansky J, Strassman RJ, Rausch JL, Gillin JC, Judd LL, Huey LY. Dexamethasone effects on self-rated mood in depressed inpatients. Am J Psychiatry. 1984 Jan; 141(1):147-8. PMID: 6691443.
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    110. Janowsky D, Curtis G, Zisook S, Kuhn K, Resovsky K, Le Winter M. Trazodone-aggravated ventricular arrhythmias. J Clin Psychopharmacol. 1983 Dec; 3(6):372-6. PMID: 6196381.
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    111. Janowsky D, Risch SC, Huey LY, Judd LL, Rausch JL. Hypothalamic-pituitary-adrenal regulation, neurotransmitters and affective disorders. Peptides. 1983 Sep-Oct; 4(5):775-84. PMID: 6140674.
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    112. Janowsky D, Curtis G, Zisook S, Kuhn K, Resovsky K, Le Winter M. Ventricular arrhythmias possibly aggravated by trazodone. Am J Psychiatry. 1983 Jun; 140(6):796-7. PMID: 6189410.
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    113. Risch SC, Janowsky D, Gillin JC, Rausch JL, Loevinger BL, Huey LY. Muscarinic supersensitivity of anterior pituitary ACTH release in major depressive illness, adrenal cortical dissociation. Psychopharmacol Bull. 1983; 19(3):343-6. PMID: 6314421.
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    114. Risch SC, Janowsky D, Siever LJ, Judd LL, Rausch JL, Huey LY, Beckman KA, Cohen RM, Murphy DL. Cholinomimetic-induced co-release of prolactin and beta-endorphin in man. Psychopharmacol Bull. 1982 Oct; 18(4):21-5. PMID: 6296908.
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    115. Rausch JL, Janowsky D, Risch SC, Judd LL, Huey LY. Hormonal and neurotransmitter hypotheses of premenstrual tension. Psychopharmacol Bull. 1982 Oct; 18(4):26-34. PMID: 6130564.
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    116. Janowsky D. Pseudodementia in the elderly: differential diagnosis and treatment. J Clin Psychiatry. 1982 Sep; 43(9 Pt 2):19-25. PMID: 7130140.
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    117. Risch SC, Groom GP, Janowsky D. The effects of psychotropic drugs on the cardiovascular system. J Clin Psychiatry. 1982 May; 43(5 Pt 2):16-31. PMID: 6122680.
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    118. Risch SC, Janowsky D, Siever LJ, Judd LJ, Rausch JL, Huey LY, Beckman KA, Cohen RM, Murphy DL. Correlated cholinomimetic-stimulated beta-endorphin and prolactin release in humans. Peptides. 1982 May-Jun; 3(3):319-22. PMID: 6289276.
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    119. Gomez RL, Janowsky D, Zetin M, Huey L, Clopton PL. Adult psychiatric diagnosis and symptoms compatible with the hyperactive child syndrome: a retrospective study. J Clin Psychiatry. 1981 Oct; 42(10):389-94. PMID: 7287634.
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    120. Risch SC, Kalin NH, Janowsky D. Cholinergic challenges in affective illness: behavioral and neuroendocrine correlates. J Clin Psychopharmacol. 1981 Jul; 1(4):186-92. PMID: 7028800.
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    121. Judd LL, Janowsky D, Zettner A, Huey LY, Takahashi KI. Effects of naloxone-HCl on cortisol levels in patients with affective disorder and normal controls. Psychiatry Res. 1981 Jun; 4(3):277-83. PMID: 6943595.
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    122. Risch SC, Groom GP, Janowsky D. Interfaces of psychopharmacology and cardiology--Part two. J Clin Psychiatry. 1981 Feb; 42(2):47-59. PMID: 6109718.
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    123. Janowsky EC, Risch C, Janowsky D. Effects of anesthesia on patients taking psychotropic drugs. J Clin Psychopharmacol. 1981 Jan; 1(1):14-20. PMID: 6117578.
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    124. Janowsky D, Davis JM, Huey L, Judd LL. Adrenergic and cholinergic drugs as episode and vulnerability markers of affective disorders and schizophrenia. Psychopharmacol Bull. 1979 Jan; 15(1):33-4. PMID: 419245.
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    125. Janowsky D, Davis JM. Adrenergic-cholinergic balance in affective disorders. Psychopharmacol Bull. 1978 Oct; 14(4):58-60. PMID: 704763.
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    126. Janowsky D, Davis JM, Huey L, Judd LL. Methylphenidate and physostigmine as diagnostic tools. Psychopharmacol Bull. 1978 Oct; 14(4):83-5. PMID: 704770.
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    127. Janowsky D, Davis JM. Methylphenidate, dextroamphetamine, and levamfetamine. Effects on schizophrenic symptoms. Arch Gen Psychiatry. 1976 Mar; 33(3):304-8. PMID: 769722.
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    128. Shopsin B, Janowsky D, Davis J, Gershon S. Rebound phenomena in manic patients following physostigmine. Preliminary observations. Neuropsychobiology. 1975; 1(3):180-7. PMID: 8744.
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    129. Shopsin B, Janowsky D, Davis J, Gershon S. Proceedings: Rebound phenomenon in manic patients following physostigmine: towards an understanding of aminergic mechanisms underlying affective disorders. Psychopharmacol Bull. 1974 Jul; 10(3):50-1. PMID: 4419431.
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    130. Davis JM, Janowsky D. Proceedings: Cholinergic and adrenergic balance in mania and schizophrenia. Psychopharmacol Bull. 1974 Jul; 10(3):49-50. PMID: 4419332.
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    131. Fann WE, Davis JM, Janowsky D, Kaufmann JS, Cavanaugh JH, Oates JA. Effect of antidepressant and antimanic drugs on amine uptake in man. J Nerv Ment Dis. 1974 May; 158(5):361-8. PMID: 4596092.
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    132. Janowsky D, el-Yousef MK, Davis JM. Acetylcholine and depression. Psychosom Med. 1974 May-Jun; 36(3):248-57. PMID: 4829619.
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    133. Janowsky D, el-Yousef MK, Davis JM. Interpersonal maneuvers of manic patients. Am J Psychiatry. 1974 Mar; 131(3):250-5. PMID: 4812683.
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    134. Nixon RL, Janowsky D, Davis JM. Effects of progesterone, beta-estradiol, and testosterone on the uptake and metabolism of 3H-norepinephrine, 3H-dopamine and 3H-serotonin in rat brain synaptosomes. Res Commun Chem Pathol Pharmacol. 1974 Jan; 7(1):233-6. PMID: 4811456.
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    135. Davis JM, Janowsky D, Sekerke HJ, Manier H, el-Yousef MK. The pharmacokinetics of butaperazine in serum. Adv Biochem Psychopharmacol. 1974; 9(0):433-43. PMID: 4151767.
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    136. Janowsky D, Davis JM. Dopamine, psychomotor stimulants, and schizophrenia: effects of methylphenidate and the stereoisomers of amphetamine in schizophrenics. Adv Biochem Psychopharmacol. 1974; 12(0):317-23. PMID: 4608582.
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    137. Janowsky D, el-Yousef MK, Davis JM, Sekerke HJ. Antagonistic effects of physostigmine and methylphenidate in man. Am J Psychiatry. 1973 Dec; 130(12):1370-6. PMID: 4754682.
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    138. El-Yousef MK, Janowsky D, Davis JM, Rosenblatt JE. Induction of severe depression by physostigmine in marihuana intoxicated individuals. Br J Addict Alcohol Other Drugs. 1973 Dec; 68(4):321-5. PMID: 4528602.
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    139. Fann WE, Davis JM, Janowsky D, Sekerke HJ, Schmidt DM. Chlorpromazine: effects of antacids on its gastrointestinal absorption. J Clin Pharmacol. 1973 Oct; 13(10):388-90. PMID: 4355737.
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    140. Janowsky D, el-Yousef MK, Davis JM, Fann WE. Antagonism of guanethidine by chlorpromazine. Am J Psychiatry. 1973 Jul; 130(7):808-12. PMID: 4712739.
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    141. Janowsky D, el-Yousef K, Davis JM, Sekerke HJ. Parasympathetic suppression of manic symptoms by physostigmine. Arch Gen Psychiatry. 1973 Apr; 28(4):542-7. PMID: 4692153.
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    142. Janowsky D, Berens SC, Davis JM. Correlations between mood, weight, and electrolytes during the menstrual cycle: a renin-angiotensin-aldosterone hypothesis of premenstrual tension. Psychosom Med. 1973 Mar-Apr; 35(2):143-54. PMID: 4350142.
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    143. el-Yousef MK, Janowsky D, Davis JM, Sekerke HJ. Reversal of antiparkinsonian drug toxicity by physostigmine: a controlled study. Am J Psychiatry. 1973 Feb; 130(2):141-5. PMID: 4405503.
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    144. Janowsky D, el-Yousel MK, Davis JM, Sekerke HJ. Provocation of schizophrenic symptoms by intravenous administration of methylphenidate. Arch Gen Psychiatry. 1973 Feb; 28(2):185-91. PMID: 4630714.
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    145. Janowsky D, el-Yousef MK, Davis JM, Sekerke HJ. A cholinergic-adrenergic hypothesis of mania and depression. Lancet. 1972 Sep 23; 2(7778):632-5. PMID: 4116781.
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    146. el-Yousef MK, Davis JM, Janowsky D, Fann WE. Central atropine-like toxicity in combined psychotropic drug administration. J Tenn Med Assoc. 1972 Aug; 65(8):719. PMID: 4152620.
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    147. Janowsky D, el-Yousef MK, Davis JM, Fann WE, Oates JA. Guanethidine antagonism by antipsychotic drugs. J Tenn Med Assoc. 1972 Jul; 65(7):620-2. PMID: 4671681.
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    148. Janowsky D, el-Yousef MK, Davis JM, Hubbard B, Sekerke HJ. Cholinergic reversal of manic symptoms. Lancet. 1972 Jun 03; 1(7762):1236-7. PMID: 4113219.
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    149. Christoph GW, Schmidt DE, Davis JM, Janowsky D. A method for determination of chlorpromazine in human blood serum. Clin Chim Acta. 1972 May; 38(2):265-70. PMID: 5026350.
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    150. Rosenblatt JE, Janowsky D, Davis JM, el-Yousef MK. The augmentation of physostigmine toxicity in the rat by 9 -tetrahydrocannabinol. Res Commun Chem Pathol Pharmacol. 1972 May; 3(3):479-82. PMID: 5034509.
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    151. Janowsky D, el-Yousef MK, Davis JM, Sekerke HJ, Morris DR, Decker B. Effects of amantadine on tardive dyskinesia and pseudo-parkinsonism. N Engl J Med. 1972 Apr 06; 286(14):785. PMID: 4554521.
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    152. el-Yosef MK, Janowsky D, Davis JM, Sekerke HJ. Reversal of benztropine toxicity by physostigmine. JAMA. 1972 Apr 03; 220(1):125. PMID: 5066746.
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    153. Fann WE, Davis JM, Janowsky D. The prevalence of tardive dyskinesias in mental hospital patients. Dis Nerv Syst. 1972 Mar; 33(3):182-6. PMID: 5022453.
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    154. Fann WE, Davis JM, Janowsky D, Kaufmann JS, Griffith JD, Oates JA. Effect of iprindole on amine uptake in man. Arch Gen Psychiatry. 1972 Feb; 26(2):158-62. PMID: 5060401.
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    155. Fann WE, Davis JM, Janowsky D, Cavanaugh JH, Kaufmann JS, Griffith JD, Oates JA. Effects of lithium on adrenergic function in man. Clin Pharmacol Ther. 1972 Jan-Feb; 13(1):71-7. PMID: 5008194.
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    156. Janowsky D, Davis JM, Fann WE, Freeman J, Nixon R, Michelakis AA. Angiotensin effect on uptake of norepinephrine by synaptosomes. Life Sci I. 1972 Jan 01; 11(1):1-11. PMID: 4347214.
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    157. Janowsky D, Fann WE, Davis JM. Monoamines and ovarian hormone-linked sexual and emotional changes: A review. Arch Sex Behav. 1971 Sep; 1(3):205-18. PMID: 24179066.
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    158. Fann WE, Janowsky D, Davis JM, Oates JA. Chlorpromazine reversal of the antihypertensive action of guanethidine. Lancet. 1971 Aug 21; 2(7721):436-7. PMID: 4105208.
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    159. Fann WE, Cavanaugh JH, Kaufmann JS, Griffith JD, Davis JM, Janowsky D, Oates JA. Doxepin: effects on transport of biogenic amines in man. Psychopharmacologia. 1971; 22(2):111-25. PMID: 5124185.
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    160. Vogel SA, Janowsky D, Davis JM. Effect of estradiol on stimulus-induced release of 3 H-norepinephrine and 3 H-serotonin from rat brain slices. Res Commun Chem Pathol Pharmacol. 1970 Jul; 1(4):451-9. PMID: 5524256.
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    161. Janowsky D, Davis JM. Progesterone-estrogen effects on uptake and release of norepinephrine by synaptosomes. Life Sci. 1970 May 01; 9(9):525-31. PMID: 5452523.
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    162. Curry SH, Marshall JH, Davis JM, Janowsky D. Chlorpromazine plasma levels and effects. Arch Gen Psychiatry. 1970 Apr; 22(4):289-96. PMID: 5417623.
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    163. Curry SH, Davis JM, Janowsky D, Marshall JH. Factors affecting chlorpromazine plasma levels in psychiatric patients. Arch Gen Psychiatry. 1970 Mar; 22(3):209-15. PMID: 5413268.
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    164. Bunney WE, Janowsky D, Goodwin FK, Davis JM, Brodie HK, Murphy DL, Chase TN. Effect of L-DOPA on depression. Lancet. 1969 Apr 26; 1(7600):885-6. PMID: 4180540.
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