Arthur Brody

TitleProfessor In Residence
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0603
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    UCLAResidency1994Department of Psychiatry
    Tufts UniversityM.D.1990School of Medicine
    Vassar CollegeB.A.1986
    Collapse Awards and Honors
    UCLA Department of Psychiatry2009  - 2012Richard Metzner Endowed Chair
    Neuropsychopharmacology2013  - 2015Reviewer Appreciation Award
    VA Clinical Science Research and Development Services  - 2009Certificate of Appreciation
    American Psychiatric Association  - 2008Distinguished Fellow
    Department of Veterans Affairs2003  - 2003Goal Sharing Award
    National Alliance for Research on Schizophrenia and Depression1995  - 1997Daniel X. Freeman Award
    Vassar College1982  - 1986Cum Laude

    Collapse Overview 
    Collapse Overview
    Research and Clinical Interests: Tobacco Use Disorder; Positron Emission Tomography; Treatment of Cigarette Smoking

    Collapse Research 
    Collapse Research Activities and Funding
    Cross-species studies of smoking effects on cognition and neuroinflammation in HIV
    NIH/NIDA R01DA044909Aug 1, 2017 - Jul 31, 2022
    Role: Co-Principal Investigator
    Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    VA I01CX000412Jan 1, 2013 - Dec 31, 2017
    Role: Principal Investigator
    Brain Nicotine Receptor Density &Response to Nicotine Patch
    NIH/NIDA R01DA020872Sep 30, 2005 - Jun 30, 2014
    Role: Principal Investigator
    Treatments for Nicotine Dependence: Brain Mechanisms
    NIH/NIDA R01DA015059Sep 30, 2002 - Aug 31, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Brody A, Hubert R, Enoki R, Garcia LY, Mamoun MS, Okita K, London ED, Nurmi EL, Seaman LC, Mandelkern MA. Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [11C]DAA1106 Positron Emission Tomography Study. Neuropsychopharmacology. 2018 Mar; 43(4):925. PMID: 29422498.
      View in: PubMed
    2. Brody A, Hubert R, Enoki R, Garcia LY, Mamoun MS, Okita K, London ED, Nurmi EL, Seaman LC, Mandelkern MA. Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [11C]DAA1106 Positron Emission Tomography Study. Neuropsychopharmacology. 2017 Jul; 42(8):1630-1639. PMID: 28262740.
      View in: PubMed
    3. Sultzer DL, Melrose RJ, Riskin-Jones H, Narvaez TA, Veliz J, Ando TK, Juarez KO, Harwood DG, Brody A, Mandelkern MA. Cholinergic Receptor Binding in Alzheimer Disease and Healthy Aging: Assessment In Vivo with Positron Emission Tomography Imaging. Am J Geriatr Psychiatry. 2017 Apr; 25(4):342-353. PMID: 28162919.
      View in: PubMed
    4. Brody A, Zorick T, Hubert R, Hellemann GS, Balali S, Kawasaki SS, Garcia LY, Enoki R, Abraham P, Young P, McCreary C. Combination Extended Smoking Cessation Treatment Plus Home Visits for Smokers With Schizophrenia: A Randomized Controlled Trial. Nicotine Tob Res. 2017 Jan; 19(1):68-76. PMID: 27613888.
      View in: PubMed
    5. Brody A, Hubert R, Mamoun MS, Enoki R, Garcia LY, Abraham P, Young P, Mandelkern MA. Nicotinic acetylcholine receptor availability in cigarette smokers: effect of heavy caffeine or marijuana use. Psychopharmacology (Berl). 2016 09; 233(17):3249-57. PMID: 27370018.
      View in: PubMed
    6. Dubroff JG, Doot RK, Falcone M, Schnoll RA, Ray R, Tyndale RF, Brody A, Hou C, Schmitz A, Lerman C. Decreased Nicotinic Receptor Availability in Smokers with Slow Rates of Nicotine Metabolism. J Nucl Med. 2015 Nov; 56(11):1724-9. PMID: 26272810; PMCID: PMC4646418.
    7. Brody A, McClernon FJ. Prediction of smoking cessation with treatment: the emerging contribution of brain imaging research. Neuropsychopharmacology. 2015 May; 40(6):1309-10. PMID: 25868069; PMCID: PMC4397413.
    8. Mamoun M, Bergen AW, Shieh J, Wiggins A, Brody A. Biomarkers of Response to Smoking Cessation Pharmacotherapies: Progress to Date. CNS Drugs. 2015 May; 29(5):359-69. PMID: 25895022; PMCID: PMC4470763.
    9. Zorick T, Mandelkern MA, Brody A. A naturalistic study of the association between antidepressant treatment and outcome of smoking cessation treatment. J Clin Psychiatry. 2014 Dec; 75(12):e1433-8. PMID: 25551240; PMCID: PMC4666295.
    10. Brody A, Okita K, Shieh J, Liang L, Hubert R, Mamoun M, Farahi J, Mandelkern MA. Radiation dosimetry and biodistribution of the translocator protein radiotracer [(11)C]DAA1106 determined with PET/CT in healthy human volunteers. Nucl Med Biol. 2014 Nov-Dec; 41(10):871-5. PMID: 25156039; PMCID: PMC4192057.
    11. Brody A, Mukhin AG, Mamoun MS, Luu T, Neary M, Liang L, Shieh J, Sugar CA, Rose JE, Mandelkern MA. Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment: a randomized trial. JAMA Psychiatry. 2014 Jul 01; 71(7):797-805. PMID: 24850280; PMCID: PMC4634637.
    12. Storage S, Mandelkern MA, Phuong J, Kozman M, Neary MK, Brody A. A positive relationship between harm avoidance and brain nicotinic acetylcholine receptor availability. Psychiatry Res. 2013 Dec 30; 214(3):415-21. PMID: 24148908; PMCID: PMC3851586.
    13. Jasinska AJ, Zorick T, Brody A, Stein EA. Dual role of nicotine in addiction and cognition: a review of neuroimaging studies in humans. Neuropharmacology. 2014 Sep; 84:111-22. PMID: 23474015.
      View in: PubMed
    14. Brody A, Mukhin AG. Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density. Neuropsychopharmacology. 2013 Jul; 38(8):1548-56. PMID: 23429692; PMCID: PMC3682149.
    15. Culbertson CS, Shulenberger S, De La Garza R, Newton TF, Brody A. VIRTUAL REALITY CUE EXPOSURE THERAPY FOR THE TREATMENT OF TOBACCO DEPENDENCE. J Cyber Ther Rehabil. 2012; 5(1):57-64. PMID: 25342999.
      View in: PubMed
    16. Anderson A, Bramen J, Douglas PK, Lenartowicz A, Cho A, Culbertson C, Brody A, Yuille AL, Cohen MS. Large Sample Group Independent Component Analysis of Functional Magnetic Resonance Imaging Using Anatomical Atlas-Based Reduction and Bootstrapped Clustering. Int J Imaging Syst Technol. 2011 Jun; 21(2):223-231. PMID: 22049263.
      View in: PubMed
    17. Culbertson CS, Bramen J, Cohen MS, London ED, Olmstead RE, Gan JJ, Costello MR, Shulenberger S, Mandelkern MA, Brody A. Effect of bupropion treatment on brain activation induced by cigarette-related cues in smokers. Arch Gen Psychiatry. 2011 May; 68(5):505-15. PMID: 21199957; PMCID: PMC3214639.
    18. Brody A, London ED, Olmstead RE, Allen-Martinez Z, Shulenberger S, Costello MR, Abrams AL, Scheibal D, Farahi J, Shoptaw S, Mandelkern MA. Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence. Psychiatry Res. 2010 Sep 30; 183(3):218-24. PMID: 20682457; PMCID: PMC2947623.
    19. Culbertson C, Nicolas S, Zaharovits I, London ED, De La Garza R, Brody A, Newton TF. Methamphetamine craving induced in an online virtual reality environment. Pharmacol Biochem Behav. 2010 Oct; 96(4):454-60. PMID: 20643158; PMCID: PMC2951480.
    20. Azizian A, Nestor LJ, Payer D, Monterosso JR, Brody A, London ED. Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task. Neuropsychopharmacology. 2010 Feb; 35(3):775-82. PMID: 19907418; PMCID: PMC2813980.
    21. Costello MR, Mandelkern MA, Shoptaw S, Shulenberger S, Baker SK, Abrams AL, Xia C, London ED, Brody A. Effects of treatment for tobacco dependence on resting cerebral glucose metabolism. Neuropsychopharmacology. 2010 Feb; 35(3):605-12. PMID: 19865076; PMCID: PMC2813904.
    22. Brody A, Olmstead RE, Abrams AL, Costello MR, Khan A, Kozman D, Saxena S, Farahi J, London ED, Mandelkern MA. Effect of a history of major depressive disorder on smoking-induced dopamine release. Biol Psychiatry. 2009 Nov 01; 66(9):898-901. PMID: 19640507; PMCID: PMC2763050.
    23. Sharma A, Brody A. In vivo brain imaging of human exposure to nicotine and tobacco. Handb Exp Pharmacol. 2009; (192):145-71. PMID: 19184649; PMCID: PMC2893588.
    24. Xu J, Azizian A, Monterosso J, Domier CP, Brody A, Fong TW, London ED. Gender effects on mood and cigarette craving during early abstinence and resumption of smoking. Nicotine Tob Res. 2008 Nov; 10(11):1653-61. PMID: 18988078; PMCID: PMC2774521.
    25. Brody A, Mandelkern MA, Costello MR, Abrams AL, Scheibal D, Farahi J, London ED, Olmstead RE, Rose JE, Mukhin AG. Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette. Int J Neuropsychopharmacol. 2009 Apr; 12(3):305-16. PMID: 18706128; PMCID: PMC2773668.
    26. Brody A, Mandelkern MA, Olmstead RE, Allen-Martinez Z, Scheibal D, Abrams AL, Costello MR, Farahi J, Saxena S, Monterosso J, London ED. Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette. Neuropsychopharmacology. 2009 Jan; 34(2):282-9. PMID: 18563061; PMCID: PMC2777990.
    27. Azizian A, Monterosso JR, Brody A, Simon SL, London ED. Severity of nicotine dependence moderates performance on perceptual-motor tests of attention. Nicotine Tob Res. 2008 Apr; 10(4):599-606. PMID: 18418782; PMCID: PMC2773663.
    28. Domier CP, Monterosso JR, Brody A, Simon SL, Mendrek A, Olmstead R, Jarvik ME, Cohen MS, London ED. Effects of cigarette smoking and abstinence on Stroop task performance. Psychopharmacology (Berl). 2007 Nov; 195(1):1-9. PMID: 17634928; PMCID: PMC2796691.
    29. Gershon Grand RB, Hwang S, Han J, George T, Brody A. Short-term naturalistic treatment outcomes in cigarette smokers with substance abuse and/or mental illness. J Clin Psychiatry. 2007 Jun; 68(6):892-8; quiz 980-1. PMID: 17592914; PMCID: PMC2893593.
    30. Brody A, Mandelkern MA, Olmstead RE, Jou J, Tiongson E, Allen V, Scheibal D, London ED, Monterosso JR, Tiffany ST, Korb A, Gan JJ, Cohen MS. Neural substrates of resisting craving during cigarette cue exposure. Biol Psychiatry. 2007 Sep 15; 62(6):642-51. PMID: 17217932; PMCID: PMC1992815.
    31. Xu J, Mendrek A, Cohen MS, Monterosso J, Simon S, Jarvik M, Olmstead R, Brody A, Ernst M, London ED. Effect of cigarette smoking on prefrontal cortical function in nondeprived smokers performing the Stroop Task. Neuropsychopharmacology. 2007 Jun; 32(6):1421-8. PMID: 17164821; PMCID: PMC2876092.
    32. Xu J, Mendrek A, Cohen MS, Monterosso J, Simon S, Brody A, Jarvik M, Rodriguez P, Ernst M, London ED. Effects of acute smoking on brain activity vary with abstinence in smokers performing the N-Back task: a preliminary study. Psychiatry Res. 2006 Dec 01; 148(2-3):103-9. PMID: 17088048; PMCID: PMC1817900.
    33. Brody A, Mandelkern MA, London ED, Olmstead RE, Farahi J, Scheibal D, Jou J, Allen V, Tiongson E, Chefer SI, Koren AO, Mukhin AG. Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. Arch Gen Psychiatry. 2006 Aug; 63(8):907-15. PMID: 16894067; PMCID: PMC2773659.
    34. Brody A, Mandelkern MA, Olmstead RE, Scheibal D, Hahn E, Shiraga S, Zamora-Paja E, Farahi J, Saxena S, London ED, McCracken JT. Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens. Arch Gen Psychiatry. 2006 Jul; 63(7):808-16. PMID: 16818870; PMCID: PMC2873693.
    35. Saxena S, Brody A, Maidment KM, Baxter LR. Paroxetine treatment of compulsive hoarding. J Psychiatr Res. 2007 Sep; 41(6):481-7. PMID: 16790250; PMCID: PMC2876089.
    36. Mendrek A, Monterosso J, Simon SL, Jarvik M, Brody A, Olmstead R, Domier CP, Cohen MS, Ernst M, London ED. Working memory in cigarette smokers: comparison to non-smokers and effects of abstinence. Addict Behav. 2006 May; 31(5):833-44. PMID: 16009504; PMCID: PMC2773651.
    37. Brody A. Functional brain imaging of tobacco use and dependence. J Psychiatr Res. 2006 Aug; 40(5):404-18. PMID: 15979645; PMCID: PMC2876087.
    38. Brody A, Olmstead RE, London ED, Farahi J, Meyer JH, Grossman P, Lee GS, Huang J, Hahn EL, Mandelkern MA. Smoking-induced ventral striatum dopamine release. Am J Psychiatry. 2004 Jul; 161(7):1211-8. PMID: 15229053.
      View in: PubMed
    39. Brody A, Mandelkern MA, Lee G, Smith E, Sadeghi M, Saxena S, Jarvik ME, London ED. Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study. Psychiatry Res. 2004 Apr 30; 130(3):269-81. PMID: 15135160; PMCID: PMC2773650.
    40. Brody A, Mandelkern MA, Jarvik ME, Lee GS, Smith EC, Huang JC, Bota RG, Bartzokis G, London ED. Differences between smokers and nonsmokers in regional gray matter volumes and densities. Biol Psychiatry. 2004 Jan 01; 55(1):77-84. PMID: 14706428.
      View in: PubMed
    41. Saxena S, Brody A, Ho ML, Zohrabi N, Maidment KM, Baxter LR. Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression. Am J Psychiatry. 2003 Mar; 160(3):522-32. PMID: 12611834.
      View in: PubMed
    42. Brody A, Mandelkern MA, London ED, Childress AR, Lee GS, Bota RG, Ho ML, Saxena S, Baxter LR, Madsen D, Jarvik ME. Brain metabolic changes during cigarette craving. Arch Gen Psychiatry. 2002 Dec; 59(12):1162-72. PMID: 12470133.
      View in: PubMed
    43. Saxena S, Brody A, Ho ML, Alborzian S, Maidment KM, Zohrabi N, Ho MK, Huang SC, Wu HM, Baxter LR. Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression. Arch Gen Psychiatry. 2002 Mar; 59(3):250-61. PMID: 11879163.
      View in: PubMed
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