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Samuel Barnes

Title(s)Associate Adjunct Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Neural Circuitry of Repetitive Behavior
    NIH/NIMH RF1MH122838Apr 1, 2020 - Mar 31, 2022
    Role: Co-Principal Investigator
    Cortical modulation of monoaminergic neurotransmission during feedback-driven decision-making and goal-directed behavior
    NIH/NIMH R21MH117518Feb 15, 2019 - Dec 31, 2020
    Role: Principal Investigator
    Early postnatal disruptions to glutamate and GABA systems and their contribution to reward deficits
    NIH R01MH108653Jul 15, 2016 - Apr 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Identification of conserved frontal neurophysiological markers of cognitive flexibility in humans and rats. Commun Biol. 2025 Aug 23; 8(1):1268. Der-Avakian A, Barnes SA, Lees T, Schroder HS, Kangas BD, Linton SR, Nickels S, Robble MA, Breiger M, Iturra-Mena AM, Lobien R, Perlo S, Cárdenas EF, Nowicki GP, Wu Z, Pan H, Dillon DG, Kesby JP, Bergman J, Carlezon WA, Risbrough VB, Mukamel E, Leutgeb S, Pizzagalli DA. PMID: 40849367; PMCID: PMC12375130.
      View in: PubMed   Mentions: Translation:HumansAnimals
    2. Dynamically Adjusting Intertemporal Choice Task in Rodents. Eur J Neurosci. 2025 Apr; 61(7):e70104. Salimi M, Nazari M, Koloski MF, Barnes SA, Mishler J, Jomehpour S, Ramanathan DS. PMID: 40219999.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix. J Neurochem. 2025 Jan; 169(1):e16243. Dexter TD, Roberts BZ, Ayoub SM, Noback M, Barnes SA, Young JW. PMID: 39463161; PMCID: PMC11996045.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    4. Author Correction: Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models. EMBO J. 2024 Sep; 43(17):3807-3811. Rueda-Carrasco J, Sokolova D, Lee SE, Childs T, Jurcáková N, Crowley G, De Schepper S, Ge JZ, Lachica JI, Toomey CE, Freeman OJ, Hardy J, Barnes SJ, Lashley T, Stevens B, Chang S, Hong S. PMID: 39085649; PMCID: PMC11377753.
      View in: PubMed   Mentions:    Fields:    
    5. Sex differences in risk-based decision-making and the modulation of risk preference by dopamine-2 like receptors in rats. Neuropharmacology. 2024 May 01; 248:109851. Ayoub SM, Libster AM, Barnes SA, Dulawa SC, Young JW. PMID: 38325772; PMCID: PMC11227321.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. Age-related dysregulation of homeostatic control in neuronal microcircuits. Nat Neurosci. 2023 12; 26(12):2158-2170. Radulescu CI, Doostdar N, Zabouri N, Melgosa-Ecenarro L, Wang X, Sadeh S, Pavlidi P, Airey J, Kopanitsa M, Clopath C, Barnes SJ. PMID: 37919424; PMCID: PMC10689243.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    7. Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases. Nat Commun. 2023 08 28; 14(1):5247. Nutma E, Fancy N, Weinert M, Tsartsalis S, Marzin MC, Muirhead RCJ, Falk I, Breur M, de Bruin J, Hollaus D, Pieterman R, Anink J, Story D, Chandran S, Tang J, Trolese MC, Saito T, Saido TC, Wiltshire KH, Beltran-Lobo P, Phillips A, Antel J, Healy L, Dorion MF, Galloway DA, Benoit RY, Amossé Q, Ceyzériat K, Badina AM, Kövari E, Bendotti C, Aronica E, Radulescu CI, Wong JH, Barron AM, Smith AM, Barnes SJ, Hampton DW, van der Valk P, Jacobson S, Howell OW, Baker D, Kipp M, Kaddatz H, Tournier BB, Millet P, Matthews PM, Moore CS, Amor S, Owen DR. PMID: 37640701; PMCID: PMC10462763.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    8. Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models. EMBO J. 2023 10 04; 42(19):e113246. Rueda-Carrasco J, Sokolova D, Lee SE, Childs T, Jurcáková N, Crowley G, De Schepper S, Ge JZ, Lachica JI, Toomey CE, Freeman OJ, Hardy J, Barnes SJ, Lashley T, Stevens B, Chang S, Hong S. PMID: 37575021; PMCID: PMC10548173.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    9. Postnatal Phencyclidine-Induced Deficits in Decision Making Are Ameliorated by Optogenetic Inhibition of Ventromedial Orbitofrontal Cortical Glutamate Neurons. Biol Psychiatry Glob Open Sci. 2024 Jan; 4(1):264-274. Tranter MM, Faget L, Hnasko TS, Powell SB, Dillon DG, Barnes SA. PMID: 38298783; PMCID: PMC10829674.
      View in: PubMed   Mentions: 4  
    10. CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. Transl Psychiatry. 2023 05 12; 13(1):167. Sanchez-Roige S, Jennings MV, Thorpe HHA, Mallari JE, van der Werf LC, Bianchi SB, Huang Y, Lee C, Mallard TT, Barnes SA, Wu JY, Barkley-Levenson AM, Boussaty EC, Snethlage CE, Schafer D, Babic Z, Winters BD, Watters KE, Biederer T, 23andMe Research Team, Mackillop J, Stephens DN, Elson SL, Fontanillas P, Khokhar JY, Young JW, Palmer AA. PMID: 37173343; PMCID: PMC10182097.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    11. Modulation of ventromedial orbitofrontal cortical glutamatergic activity affects the explore-exploit balance and influences value-based decision-making. Cereb Cortex. 2023 05 09; 33(10):5783-5796. Barnes SA, Dillon DG, Young JW, Thomas ML, Faget L, Yoo JH, Der-Avakian A, Hnasko TS, Geyer MA, Ramanathan DS. PMID: 36472411; PMCID: PMC10183731.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    12. Short-active gestational photoperiod reduces effortful choice behavior in mice, partial normalization by d-amphetamine. Psychopharmacology (Berl). 2023 Nov; 240(11):2303-2315. Roberts BZ, O'Connor MA, Kenton JA, Barnes SA, Young JW. PMID: 36806900.
      View in: PubMed   Mentions: 1     Fields:    
    13. Homeostatic regulation through strengthening of neuronal network-correlated synaptic inputs. Elife. 2022 12 14; 11. Barnes SJ, Keller GB, Keck T. PMID: 36515269; PMCID: PMC9803349.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    14. Reinforcement learning deficits exhibited by postnatal PCP-treated rats enable deep neural network classification. Neuropsychopharmacology. 2023 08; 48(9):1377-1385. Tranter MM, Aggarwal S, Young JW, Dillon DG, Barnes SA. PMID: 36509858; PMCID: PMC10354061.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    15. Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease. Proc Natl Acad Sci U S A. 2022 10 25; 119(43):e2206083119. Dehghan A, Pinto RC, Karaman I, Huang J, Durainayagam BR, Ghanbari M, Nazeer A, Zhong Q, Liggi S, Whiley L, Mustafa R, Kivipelto M, Solomon A, Ngandu T, Kanekiyo T, Aikawa T, Radulescu CI, Barnes SJ, Graça G, Chekmeneva E, Camuzeaux S, Lewis MR, Kaluarachchi MR, Ikram MA, Holmes E, Tzoulaki I, Matthews PM, Griffin JL, Elliott P. PMID: 36269859; PMCID: PMC9618092.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    16. Seasonal changes in day length induce multisynaptic neurotransmitter switching to regulate hypothalamic network activity and behavior. Sci Adv. 2022 Sep 02; 8(35):eabn9867. Porcu A, Nilsson A, Booreddy S, Barnes SA, Welsh DK, Dulcis D. PMID: 36054362; PMCID: PMC10848959.
      View in: PubMed   Mentions: 28     Fields:    
    17. Effects of modafinil on electroencephalographic microstates in healthy adults. Psychopharmacology (Berl). 2022 Aug; 239(8):2573-2584. Linton SR, Murphy M, Schroder HS, Breiger M, Iturra-Mena AM, Kangas BD, Bergman J, Carlezon WA, Risbrough VB, Barnes SA, Der-Avakian A, Pizzagalli DA. PMID: 35471613; PMCID: PMC9296596.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. Error-related Alpha Suppression: Scalp Topography and (Lack of) Modulation by Modafinil. J Cogn Neurosci. 2022 03 31; 34(5):864-876. Schroder HS, Iturra-Mena AM, Breiger M, Linton SR, Robble MA, Kangas BD, Bergman J, Nickels S, Vitaliano G, Der-Avakian A, Barnes SA, Carlezon WA, Pizzagalli DA. PMID: 35195725.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting. Genes Brain Behav. 2022 04; 21(4):e12800. Sanchez-Roige S, Barnes SA, Mallari J, Wood R, Polesskaya O, Palmer AA. PMID: 35243767; PMCID: PMC9211103.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    20. Concordant neurophysiological signatures of cognitive control in humans and rats. Neuropsychopharmacology. 2021 06; 46(7):1252-1262. Robble MA, Schroder HS, Kangas BD, Nickels S, Breiger M, Iturra-Mena AM, Perlo S, Cardenas E, Der-Avakian A, Barnes SA, Leutgeb S, Risbrough VB, Vitaliano G, Bergman J, Carlezon WA, Pizzagalli DA. PMID: 33746206; PMCID: PMC8134486.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    21. Multi-scale network imaging in a mouse model of amyloidosis. Cell Calcium. 2021 05; 95:102365. Doostdar N, Airey J, Radulescu CI, Melgosa-Ecenarro L, Zabouri N, Pavlidi P, Kopanitsa M, Saito T, Saido T, Barnes SJ. PMID: 33610083.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    22. Convergent observations of MK-801-induced impairment in rat 5C-CPT performance across laboratories: reversal with a D1 but not nicotinic agonist. Psychopharmacology (Berl). 2021 Apr; 238(4):979-990. Grottick AJ, MacQueen DL, Barnes SA, Carroll C, Sanabria EK, Bobba V, Young JW. PMID: 33404734.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    23. Reward motivation and cognitive flexibility in tau null-mutation mice. Neurobiol Aging. 2021 04; 100:106-117. Oberrauch S, Metha JA, Brian ML, Barnes SA, Featherby TJ, Lawrence AJ, Hoyer D, Murawski C, Jacobson LH. PMID: 33524848.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    24. Separating Probability and Reversal Learning in a Novel Probabilistic Reversal Learning Task for Mice. Front Behav Neurosci. 2019; 13:270. Metha JA, Brian ML, Oberrauch S, Barnes SA, Featherby TJ, Bossaerts P, Murawski C, Hoyer D, Jacobson LH. PMID: 31998088; PMCID: PMC6962304.
      View in: PubMed   Mentions: 16  
    25. Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex. Nat Commun. 2019 12 12; 10(1):5684. Knöpfel T, Sweeney Y, Radulescu CI, Zabouri N, Doostdar N, Clopath C, Barnes SJ. PMID: 31831751; PMCID: PMC6908602.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    26. In vivo modeling of human neuron dynamics and Down syndrome. Science. 2018 11 16; 362(6416). Real R, Peter M, Trabalza A, Khan S, Smith MA, Dopp J, Barnes SJ, Momoh A, Strano A, Volpi E, Knott G, Livesey FJ, De Paola V. PMID: 30309905; PMCID: PMC6570619.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    27. Correction to: The Effects of Cariprazine and Aripiprazole on PCP-Induced Deficits on Attention Assessed in the 5-Choice Serial Reaction Time Task. Psychopharmacology (Berl). 2018 05; 235(5):1621. Barnes SA, Young JW, Markou A, Adham N, Gyertyán I, Kiss B. PMID: 29564481; PMCID: PMC6713673.
      View in: PubMed   Mentions: 1     Fields:    
    28. Metabotropic Glutamate Receptor 5 as a Target for the Treatment of Depression and Smoking: Robust Preclinical Data but Inconclusive Clinical Efficacy. Biol Psychiatry. 2018 06 01; 83(11):955-962. Barnes SA, Sheffler DJ, Semenova S, Cosford NDP, Bespalov A. PMID: 29628194; PMCID: PMC5953810.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    29. Overview of the Biography and Legacy of Professor Athina Markou. Biol Psychiatry. 2018 06 01; 83(11):910-912. Geyer MA, Semenova S, Li X, Der-Avakian A, Barnes SA, Grant I. PMID: 29501205.
      View in: PubMed   Mentions:    Fields:    
    30. The Effects of Cariprazine and Aripiprazole on PCP-Induced Deficits on Attention Assessed in the 5-Choice Serial Reaction Time Task. Psychopharmacology (Berl). 2018 05; 235(5):1403-1414. Barnes SA, Young JW, Markou A, Adham N, Gyertyán I, Kiss B. PMID: 29473089; PMCID: PMC5920008.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    31. Size-Dependent Axonal Bouton Dynamics following Visual Deprivation In Vivo. Cell Rep. 2018 01 16; 22(3):576-584. Sammons RP, Clopath C, Barnes SJ. PMID: 29346758; PMCID: PMC5792425.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    32. Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss. Neuron. 2017 Nov 15; 96(4):871-882.e5. Barnes SJ, Franzoni E, Jacobsen RI, Erdelyi F, Szabo G, Clopath C, Keller GB, Keck T. PMID: 29107520; PMCID: PMC5697914.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    33. Preclinical Models to Investigate Mechanisms of Negative Symptoms in Schizophrenia. Schizophr Bull. 2017 07 01; 43(4):706-711. Barnes SA, Der-Avakian A, Young JW. PMID: 28586462; PMCID: PMC5472160.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    34. Translational Assessment of Reward and Motivational Deficits in Psychiatric Disorders. Curr Top Behav Neurosci. 2016; 28:231-62. Der-Avakian A, Barnes SA, Markou A, Pizzagalli DA. PMID: 26873017; PMCID: PMC4983255.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimals
    35. Dopamine D1 receptor activation improves PCP-induced performance disruption in the 5C-CPT by reducing inappropriate responding. Behav Brain Res. 2016 Mar 01; 300:45-55. Barnes SA, Young JW, Bate ST, Neill JC. PMID: 26658514; PMCID: PMC4767402.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    36. Subnetwork-Specific Homeostatic Plasticity in Mouse Visual Cortex In Vivo. Neuron. 2015 Jun 03; 86(5):1290-303. Barnes SJ, Sammons RP, Jacobsen RI, Mackie J, Keller GB, Keck T. PMID: 26050045; PMCID: PMC4460189.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
    37. Impaired limbic cortico-striatal structure and sustained visual attention in a rodent model of schizophrenia. Int J Neuropsychopharmacol. 2014 Oct 31; 18(2). Barnes SA, Sawiak SJ, Caprioli D, Jupp B, Buonincontri G, Mar AC, Harte MK, Fletcher PC, Robbins TW, Neill JC, Dalley JW. PMID: 25552430; PMCID: PMC4368881.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    38. Rapid Bidirectional Reorganization of Cortical Microcircuits. Cereb Cortex. 2015 Sep; 25(9):3025-35. Albieri G, Barnes SJ, de Celis Alonso B, Cheetham CE, Edwards CE, Lowe AS, Karunaratne H, Dear JP, Lee KC, Finnerty GT. PMID: 24836895; PMCID: PMC4537443.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    39. Pay attention to impulsivity: modelling low attentive and high impulsive subtypes of adult ADHD in the 5-choice continuous performance task (5C-CPT) in female rats. Eur Neuropsychopharmacol. 2014 Aug; 24(8):1371-80. Tomlinson A, Grayson B, Marsh S, Harte MK, Barnes SA, Marshall KM, Neill JC. PMID: 24882551.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    40. Anhedonia, avolition, and anticipatory deficits: assessments in animals with relevance to the negative symptoms of schizophrenia. Eur Neuropsychopharmacol. 2014 May; 24(5):744-58. Barnes SA, Der-Avakian A, Markou A. PMID: 24183826; PMCID: PMC3986268.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    41. Pansynaptic enlargement at adult cortical connections strengthened by experience. Cereb Cortex. 2014 Feb; 24(2):521-31. Cheetham CE, Barnes SJ, Albieri G, Knott GW, Finnerty GT. PMID: 23118196; PMCID: PMC3888373.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    42. D₁ receptor activation improves vigilance in rats as measured by the 5-choice continuous performance test. Psychopharmacology (Berl). 2012 Mar; 220(1):129-41. Barnes SA, Young JW, Neill JC. PMID: 21901319; PMCID: PMC5870138.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    43. Rats tested after a washout period from sub-chronic PCP administration exhibited impaired performance in the 5-Choice Continuous Performance Test (5C-CPT) when the attentional load was increased. Neuropharmacology. 2012 Mar; 62(3):1432-41. Barnes SA, Young JW, Neill JC. PMID: 21569782; PMCID: PMC5870141.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
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