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    Mahadevan Rajasekaran

    TitleAssociate Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentSurgery
    Address9500 Gilman Drive #9151
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Rajasekaran M, Kanoo S, Fu J, Nguyen ML, Bhargava V, Mittal RK. Age Related External Anal Sphincter Muscle Dysfunction & Fibrosis: Possible Role of Wnt-ß Catenin Signaling Pathways. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 24; ajpgi.00209.2017. PMID: 28838987.
        View in: PubMed
      2. Mittal RK, Sheean G, Padda BS, Rajasekaran M. Length tension function of puborectalis muscle: implications for the treatment of fecal incontinence and pelvic floor disorders. J Neurogastroenterol Motil. 2014 Oct 30; 20(4):539-46. PMID: 25273124.
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      3. Raj Rajasekaran M, Sinha S, Seo Y, Salehi M, Bhargava V, Mittal RK. Myoarchitectural and functional alterations in rabbit external anal sphincter muscle following experimental surgical trauma. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 15; 307(4):G445-51. PMID: 24994856.
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      4. Kim YS, Weinstein M, Raizada V, Jiang Y, Bhargava V, Rajasekaran M, Mittal RK. Anatomical disruption and length-tension dysfunction of anal sphincter complex muscles in women with fecal incontinence. Dis Colon Rectum. 2013 Nov; 56(11):1282-9. PMID: 24105004.
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      5. Rajasekaran M, Sohn D, Salehi M, Bhargava V, Fritsch H, Mittal RK. Role of puborectalis muscle in the genesis of urethral pressure. J Urol. 2012 Oct; 188(4):1382-8. PMID: 22906663.
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      6. Rajasekaran M, Jiang Y, Bhargava V, Ramamoorthy S, Lieber RL, Mittal RK. Sustained improvement in the anal sphincter function following surgical plication of rabbit external anal sphincter muscle. Dis Colon Rectum. 2011 Nov; 54(11):1373-80. PMID: 21979181.
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      7. Rajasekaran M, Jiang Y, Bhargava V, Lieber RL, Mittal RK. Novel applications of external anal sphincter muscle sarcomere length to enhance the anal canal function. Neurogastroenterol Motil. 2011 Jan; 23(1):70-5, e7. PMID: 20939857.
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      8. Aldridge N, Kim HW, Motamedi A, Rajasekaran M. Chronic partial bladder outlet obstruction does not impair erectile function in male rats. BJU Int. 2010 Aug; 106(4):572-7. PMID: 20002673.
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      9. Song Y, Mehta N, Sheh B, Saljooque F, U HS, Rajasekaran M. Transdifferentiation of rat fetal brain stem cells into penile smooth muscle cells. BJU Int. 2009 Jul; 104(2):257-62. PMID: 19220248.
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      10. Rajasekaran M, Jiang Y, Bhargava V, Littlefield R, Lee A, Lieber RL, Mittal RK. Length-tension relationship of the external anal sphincter muscle: implications for the anal canal function. Am J Physiol Gastrointest Liver Physiol. 2008 Aug; 295(2):G367-73. PMID: 18599590.
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      11. Mehta N, Sikka S, Rajasekaran M. Rat as an animal model for male erectile function evaluation in sexual medicine research. J Sex Med. 2008 Jun; 5(6):1278-83. PMID: 18558990.
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      12. Rajasekaran M, Mehta N, Baquir A, Kuntz S. Rho-kinase inhibition suppresses potassium chloride-induced bladder hyperactivity in a rat model. Urology. 2007 Apr; 69(4):791-4. PMID: 17445683.
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      13. Parsons CL, Rajasekaran M, Arsanjani AH, Chenoweth M, Stein P. Role of sialic acid in urinary cytoprotective activity of Tamm-Horsfall protein. Urology. 2007 Mar; 69(3):577-81. PMID: 17382182.
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      14. Sakamoto K, Suri D, Rajasekaran M. Characterization of muscarinic receptor subtypes in human ureter. J Endourol. 2006 Nov; 20(11):939-42. PMID: 17144868.
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      15. Rajasekaran M, Locke KW, Parsons CL. MN-001, a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model. BJU Int. 2006 Aug; 98(2):430-4. PMID: 16879690.
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      16. Rajasekaran M, Stein P, Parsons CL. Toxic factors in human urine that injure urothelium. Int J Urol. 2006 Apr; 13(4):409-14. PMID: 16734860.
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      17. Stein P, Rajasekaran M, Parsons CL. Tamm-Horsfall protein protects urothelial permeability barrier. Urology. 2005 Oct; 66(4):903-7. PMID: 16230179.
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      18. Rajasekaran M, White S, Baquir A, Wilkes N. Rho-kinase inhibition improves erectile function in aging male Brown-Norway rats. J Androl. 2005 Mar-Apr; 26(2):182-8. PMID: 15713824.
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      19. Rajasekaran M, Wilkes N, Kuntz S, E Albo M. Rho-kinase inhibition suppresses bladder hyperactivity in spontaneously hypertensive rats. Neurourol Urodyn. 2005; 24(3):295-300. PMID: 15791631.
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      20. Song Y, Rajasekaran M. Effect of excitatory amino acid receptor agonists on penile erection after administration into the CA3 hippocampal region in the rat. Urology. 2004 Dec; 64(6):1250-4. PMID: 15596217.
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      21. Wilkes N, White S, Stein P, Bernie J, Rajasekaran M. Phosphodiesterase-5 inhibition synergizes rho-kinase antagonism and enhances erectile response in male hypertensive rats. Int J Impot Res. 2004 Apr; 16(2):187-94. PMID: 15073608.
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      22. Rithaporn T, Monga M, Rajasekaran M. Curcumin: a potential vaginal contraceptive. Contraception. 2003 Sep; 68(3):219-23. PMID: 14561543.
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      23. Rajasekaran M, Kasyan A, Allilain W, Monga M. Ex vivo expression of angiogenic growth factors and their receptors in human penile cavernosal cells. J Androl. 2003 Jan-Feb; 24(1):85-90. PMID: 12514088.
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      24. Monga M, Rajasekaran M. Erectile dysfunction: current concepts and future directions. Arch Androl. 2003 Jan-Feb; 49(1):7-17. PMID: 12647774.
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      25. Monga M, Cosgrove D, Zupkas P, Jain A, Kasyan A, Wilkes N, Rajasekaran M. Small intestinal submucosa as a tunica albuginea graft material. J Urol. 2002 Sep; 168(3):1215-21. PMID: 12187270.
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      26. Rajasekaran M, Kasyan A, Jain A, Kim SW, Monga M. Altered growth factor expression in the aging penis: the Brown-Norway rat model. J Androl. 2002 May-Jun; 23(3):393-9. PMID: 12002441.
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      27. Monga M, Rajasekaran M. [Male sexual dysfunction with spinal cord injury and other neurologic diseases]. Zhonghua Nan Ke Xue. 2002; 8(2):79-87. PMID: 12479015.
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      28. Monga M, Gordon Z, Rajasekaran M. Spinal cord injury and male infertility. Zhonghua Nan Ke Xue. 2002; 8(4):235-40. PMID: 12491681.
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      29. Rajasekaran M, Pagnon V, Monga M. Vasoactive agents induce cytotoxicity in cultured human penile smooth muscle cells. Urology. 2002 Jan; 59(1):155-8. PMID: 11796314.
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      30. Sikka SC, Champion HC, Bivalacqua TJ, Estrada LS, Wang R, Rajasekaran M, Aggarwal BB, Hellstrom WJ. Role of genitourinary inflammation in infertility: synergistic effect of lipopolysaccharide and interferon-gamma on human spermatozoa. Int J Androl. 2001 Jun; 24(3):136-41. PMID: 11380702.
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      31. Rajasekaran M, Hellstrom WJ, Sikka SC. Nitric oxide induces oxidative stress and mediates cytotoxicity to human cavernosal cells in culture. J Androl. 2001 Jan-Feb; 22(1):34-9. PMID: 11191085.
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      32. Monga M, Dunn K, Rajasekaran M. Characterization of ultrastructural and metabolic abnormalities in semen from men with spinal cord injury. J Spinal Cord Med. 2001; 24(1):41-6. PMID: 11587434.
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      33. Bivalacqua TJ, Champion HC, Rajasekaran M, Sikka SC, Kadowitz PJ, Doherty PC, Hellstrom WJ. Potentiation of erectile response and cAMP accumulation by combination of prostaglandin E1 and rolipram, a selective inhibitor of the type 4 phosphodiesterase (PDE 4). J Urol. 1999 Nov; 162(5):1848-55. PMID: 10524946.
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      34. Monga M, Bernie J, Rajasekaran M. Male infertility and erectile dysfunction in spinal cord injury: a review. Arch Phys Med Rehabil. 1999 Oct; 80(10):1331-9. PMID: 10527097.
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      35. Rajasekaran M, Monga M. Cellular and molecular causes of male infertility in spinal cord injury. J Androl. 1999 May-Jun; 20(3):326-30. PMID: 10386809.
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      36. Armstrong JS, Rajasekaran M, Chamulitrat W, Gatti P, Hellstrom WJ, Sikka SC. Characterization of reactive oxygen species induced effects on human spermatozoa movement and energy metabolism. Free Radic Biol Med. 1999 Apr; 26(7-8):869-80. PMID: 10232830.
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      37. Rajasekaran M, Mondal D, Agrawal K, Chen IL, Hellstrom W, Sikka S. Ex vivo expression of nitric oxide synthase isoforms (eNOS/iNOS) and calmodulin in human penile cavernosal cells. J Urol. 1998 Dec; 160(6 Pt 1):2210-5. PMID: 9817372.
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      38. Bivalacqua TJ, Rajasekaran M, Champion HC, Wang R, Sikka SC, Kadowitz PJ, Hellstrom WJ. The influence of castration on pharmacologically induced penile erection in the cat. J Androl. 1998 Sep-Oct; 19(5):551-7. PMID: 9796614.
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      39. Armstrong JS, Rajasekaran M, Hellstrom WJ, Sikka SC. Antioxidant potential of human serum albumin: role in the recovery of high quality human spermatozoa for assisted reproductive technology. J Androl. 1998 Jul-Aug; 19(4):412-9. PMID: 9733143.
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      40. Estrada LS, Champion HC, Wang R, Rajasekaran M, Hellstrom WJ, Aggarwal B, Sikka SC. Effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human sperm motility, viability and motion parameters. Int J Androl. 1997 Aug; 20(4):237-42. PMID: 9401827.
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      41. Rajasekaran M, Hellstrom W, Sikka S. Quantitative assessment of cytokines (GRO alpha and IL-10) in human seminal plasma during genitourinary inflammation. Am J Reprod Immunol. 1996 Aug; 36(2):90-5. PMID: 8862252.
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      42. Sikka SC, Rajasekaran M, Hellstrom WJ. Role of oxidative stress and antioxidants in male infertility. J Androl. 1995 Nov-Dec; 16(6):464-8. PMID: 8867595.
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      43. Rajasekaran M, Hellstrom WJ, Naz RK, Sikka SC. Oxidative stress and interleukins in seminal plasma during leukocytospermia. Fertil Steril. 1995 Jul; 64(1):166-71. PMID: 7789553.
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      44. Rajasekaran M, Hellstrom WJ, Sparks RL, Sikka SC. Sperm-damaging effects of electric current: possible role of free radicals. Reprod Toxicol. 1994 Sep-Oct; 8(5):427-32. PMID: 7841663.
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      45. Rajasekaran M, Nair AG, Hellstrom WJ, Sikka SC. Spermicidal activity of an antifungal saponin obtained from the tropical herb Mollugo pentaphylla. Contraception. 1993 Apr; 47(4):401-12. PMID: 8508669.
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      46. Bell M, Sikka S, Rajasekaran M, Hellstrom W. Time course of hydrogen peroxide induced changes in the lipid peroxidation of human sperm membranes. Adv Contracept Deliv Syst. 1992; 8(1-2):144-50. PMID: 12285560.
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      47. Rajasekaran M, Bapna JS, Lakshmanan S, Ramachandran Nair AG, Veliath AJ, Panchanadam M. Antifertility effect in male rats of oleanolic acid, a triterpene from Eugenia jambolana flowers. J Ethnopharmacol. 1988 Sep; 24(1):115-21. PMID: 3199836.
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