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    Pamela Mellon

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentReproductive Medicine
    Address9500 Gilman Drive #0674
    CA La Jolla 92093
    Phone858-534-1312
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      Other Positions
      TitleProfessor of Neurosciences
      InstitutionUniversity of California, San Diego


      Collapse Research 
      Collapse Research Activities and Funding
      Neuroendocrine Actions of Androgens in Female Reproduction
      NIH/NICHD R01HD082567Apr 1, 2015 - Jan 31, 2020
      Role: Principal Investigator
      Endocrine and Growth Factor Regulation in the Pituitary
      NIH/NIDDK R01DK068121Mar 1, 2005 - Mar 31, 2005
      Role: Principal Investigator
      Diabetes Research Center (DRC)
      NIH/NIDDK P30DK063491Dec 1, 2002 - Apr 30, 2018
      Role: Co-Investigator
      DETECTION AND MODELS OF TOXICANT EXPOSURE
      NIH/NIEHS P42ES010337Jul 1, 2000 - Mar 31, 2022
      Role: Co-Investigator
      GORDON CONFERENCE ON HORMONE ACTION
      NIH/NIDDK R13DK050196Jul 28, 1995 - Jul 27, 1996
      Role: Principal Investigator
      DIVISION OF PHYSIOLOGY AND PATHOLOGY
      NIH/CSR U09RG000146Jul 1, 1994 - Sep 29, 2006
      Role: Principal Investigator
      Neurosecretory Gene Expression in the Hypothalamus
      NIH/NICHD R01HD072754Jan 1, 1992 - Jun 30, 2017
      Role: Principal Investigator
      CELL LINEAGE IN THE ANTERIOR PITUITARY
      NIH/NICHD R37HD020377Jan 1, 1992 - Jul 31, 2006
      Role: Principal Investigator
      Neurosecretory Gene Expression in the Hypothalamus
      NIH/NIDDK R01DK044838Jul 1, 1991 - Aug 31, 2012
      Role: Principal Investigator
      GLYCOPROTEIN HORMONE ALPHA SUBUNIT &GENE TRANSCRIPTION
      NIH/NICHD R01HD023818Feb 1, 1988 - Jul 31, 1993
      Role: Principal Investigator
      LUTEINIZING HORMONE IN ENDOCRINE &REPRODUCTIVE DISEASES
      NIH/NIDDK R03DK039798Sep 1, 1987 - Aug 31, 1988
      Role: Principal Investigator
      Molecular Mechanisms of Gonadotrope Differentiation
      NIH/NICHD R01HD020377Jul 1, 1985 - Jun 30, 2012
      Role: Principal Investigator
      Training in Reproductive Sciences
      NIH/NICHD T32HD007203Jul 1, 1979 - Apr 30, 2018
      Role: Principal Investigator
      Center for Reproductive Science and Medicine
      NIH/NICHD P50HD012303Dec 1, 1978 - Mar 31, 2021
      Role: Principal Investigator
      Center for Reproductive Science and Medicine
      NIH/NICHD U54HD012303Dec 1, 1978 - Mar 31, 2014
      Role: Principal Investigator
      Specialized Cancer Center Support Grant
      NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2019
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hoffmann HM, Mellon P. A small population of hypothalamic neurons govern fertility: the critical role of VAX1 in GnRH neuron development and fertility maintenance. Neurosci Commun (Houst). 2016; 2. PMID: 28164172.
        View in: PubMed
      2. Hoffmann HM, Trang C, Gong P, Kimura I, Pandolfi EC, Mellon P. Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. J Neurosci. 2016 Mar 23; 36(12):3506-18. PMID: 27013679.
        View in: PubMed
      3. Skowronska-Krawczyk D, Zhao L, Zhu J, Weinreb RN, Cao G, Luo J, Flagg K, Patel S, Wen C, Krupa M, Luo H, Ouyang H, Lin D, Wang W, Li G, Xu Y, Li O, Chung C, Yeh E, Jafari M, Ai M, Zhong Z, Shi W, Zheng L, Krawczyk M, Chen D, Shi C, Zin C, Zhu J, Mellon P, Gao W, Abagyan R, Zhang L, Sun X, Zhong S, Zhuo Y, Rosenfeld MG, Liu Y, Zhang K. P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma. Mol Cell. 2015 Sep 17; 59(6):931-40. PMID: 26365380.
        View in: PubMed
      4. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon P. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. PMID: 26203175.
        View in: PubMed
      5. Stephens SB, Tolson KP, Rouse ML, Poling MC, Hashimoto-Partyka MK, Mellon P, Kauffman AS. Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice. Endocrinology. 2015 Sep; 156(9):3091-7. PMID: 26076042.
        View in: PubMed
      6. Xie H, Hoffmann HM, Meadows JD, Mayo SL, Trang C, Leming SS, Maruggi C, Davis SW, Larder R, Mellon P. Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development. Mol Endocrinol. 2015 Jun; 29(6):842-55. PMID: 25915183.
        View in: PubMed
      7. Ahow M, Min L, Pampillo M, Nash C, Wen J, Soltis K, Carroll RS, Glidewell-Kenney CA, Mellon P, Bhattacharya M, Tobet SA, Kaiser UB, Babwah AV. KISS1R signals independently of Gaq/11 and triggers LH secretion via the ß-arrestin pathway in the male mouse. Endocrinology. 2014 Nov; 155(11):4433-46. PMID: 25147978.
        View in: PubMed
      8. Roybal LL, Hambarchyan A, Meadows JD, Barakat NH, Pepa PA, Breen KM, Mellon P, Coss D. Roles of Binding Elements, FOXL2 Domains, and Interactions With cJUN and SMADs in Regulation of FSHß. Mol Endocrinol. 2014 Oct; 28(10):1640-55. PMID: 25105693.
        View in: PubMed
      9. Hoffmann HM, Tamrazian A, Xie H, Pérez-Millán MI, Kauffman AS, Mellon P. Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology. 2014 Oct; 155(10):4043-53. PMID: 25060364.
        View in: PubMed
      10. Glidewell-Kenney CA, Trang C, Shao PP, Gutierrez-Reed N, Uzo-Okereke AM, Coss D, Mellon P. Neurokinin B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons. Endocrinology. 2014 Oct; 155(10):3909-19. PMID: 25057795.
        View in: PubMed
      11. Breen KM, Mellon P. Influence of stress-induced intermediates on gonadotropin gene expression in gonadotrope cells. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):71-7. PMID: 24012628.
        View in: PubMed
      12. Larder R, Kimura I, Meadows J, Clark DD, Mayo S, Mellon P. Gene dosage of Otx2 is important for fertility in male mice. Mol Cell Endocrinol. 2013 Sep 5; 377(1-2):16-22. PMID: 23811236.
        View in: PubMed
      13. Witham EA, Meadows JD, Hoffmann HM, Shojaei S, Coss D, Kauffman AS, Mellon P. Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol Endocrinol. 2013 Aug; 27(8):1283-94. PMID: 23770611.
        View in: PubMed
      14. Glidewell-Kenney CA, Shao PP, Iyer AK, Grove AM, Meadows JD, Mellon P. Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol Endocrinol. 2013 Mar; 27(3):437-54. PMID: 23393128.
        View in: PubMed
      15. Clark DD, Gorman MR, Hatori M, Meadows JD, Panda S, Mellon P. Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6. J Biol Rhythms. 2013 Feb; 28(1):15-25. PMID: 23382588.
        View in: PubMed
      16. Xie H, Cherrington BD, Meadows JD, Witham EA, Mellon P. Msx1 homeodomain protein represses the aGSU and GnRH receptor genes during gonadotrope development. Mol Endocrinol. 2013 Mar; 27(3):422-36. PMID: 23371388.
        View in: PubMed
      17. Brayman MJ, Pepa PA, Mellon P. Androgen receptor repression of gonadotropin-releasing hormone gene transcription via enhancer 1. Mol Cell Endocrinol. 2012 Nov 5; 363(1-2):92-9. PMID: 22877652.
        View in: PubMed
      18. Breen KM, Thackray VG, Hsu T, Mak-McCully RA, Coss D, Mellon P. Stress levels of glucocorticoids inhibit LHß-subunit gene expression in gonadotrope cells. Mol Endocrinol. 2012 Oct; 26(10):1716-31. PMID: 22851703.
        View in: PubMed
      19. Witham EA, Meadows JD, Shojaei S, Kauffman AS, Mellon P. Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology. 2012 Sep; 153(9):4522-32. PMID: 22778229.
        View in: PubMed
      20. Ghochani Y, Saini JK, Mellon P, Thackray VG. FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone ß-subunit promoter. Endocrinology. 2012 Apr; 153(4):2023-33. PMID: 22294749.
        View in: PubMed
      21. Brayman MJ, Pepa PA, Berdy SE, Mellon P. Androgen receptor repression of GnRH gene transcription. Mol Endocrinol. 2012 Jan; 26(1):2-13. PMID: 22074952.
        View in: PubMed
      22. Lan D, Lu M, Sharma S, Mellon P, Olefsky JM, Webster NJ. Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHß gene expression by a SirT1-independent pathway in LßT2 gonadotrope cells. Reprod Toxicol. 2011 Jul; 32(1):85-92. PMID: 21679764.
        View in: PubMed
      23. Beneduzzi D, Iyer AK, Trarbach EB, Silveira-Neto AP, Silveira LG, Tusset C, Yip K, Mendonça BB, Mellon P, Latronico AC. Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism. Eur J Endocrinol. 2011 Jul; 165(1):145-50. PMID: 21543378.
        View in: PubMed
      24. Yueh MF, Mellon P, Tukey RH. Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor. Mol Pharmacol. 2011 Jun; 79(6):1053-60. PMID: 21415305.
        View in: PubMed
      25. Ely HA, Mellon P, Coss D. GnRH induces the c-Fos gene via phosphorylation of SRF by the calcium/calmodulin kinase II pathway. Mol Endocrinol. 2011 Apr; 25(4):669-80. PMID: 21292826.
        View in: PubMed
      26. Iyer AK, Brayman MJ, Mellon P. Dynamic chromatin modifications control GnRH gene expression during neuronal differentiation and protein kinase C signal transduction. Mol Endocrinol. 2011 Mar; 25(3):460-73. PMID: 21239613.
        View in: PubMed
      27. Larder R, Clark DD, Miller NL, Mellon P. Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6. J Neurosci. 2011 Jan 12; 31(2):426-38. PMID: 21228153.
        View in: PubMed
      28. Sharma S, Sharma PM, Mistry DS, Chang RJ, Olefsky JM, Mellon P, Webster NJ. PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice. Biol Reprod. 2011 Mar; 84(3):466-75. PMID: 21076077.
        View in: PubMed
      29. Iyer AK, Miller NL, Yip K, Tran BH, Mellon P. Enhancers of GnRH transcription embedded in an upstream gene use homeodomain proteins to specify hypothalamic expression. Mol Endocrinol. 2010 Oct; 24(10):1949-64. PMID: 20667983.
        View in: PubMed
      30. Coss D, Mellon P, Thackray VG. A FoxL in the Smad house: activin regulation of FSH. Trends Endocrinol Metab. 2010 Sep; 21(9):562-8. PMID: 20598900.
        View in: PubMed
      31. Breen KM, Thackray VG, Coss D, Mellon P. Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene. Endocrinology. 2010 Jun; 151(6):2669-80. PMID: 20357224.
        View in: PubMed
      32. Corpuz PS, Lindaman LL, Mellon P, Coss D. FoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone beta-subunit genes. Mol Endocrinol. 2010 May; 24(5):1037-51. PMID: 20233786.
        View in: PubMed
      33. Thackray VG, Mellon P, Coss D. Hormones in synergy: regulation of the pituitary gonadotropin genes. Mol Cell Endocrinol. 2010 Jan 27; 314(2):192-203. PMID: 19747958.
        View in: PubMed
      34. Larder R, Mellon P. Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors. J Biol Chem. 2009 Jun 19; 284(25):16966-78. PMID: 19401468.
        View in: PubMed
      35. Thackray VG, Hunnicutt JL, Memon AK, Ghochani Y, Mellon P. Progesterone Inhibits basal and gonadotropin-releasing hormone induction of luteinizing hormone beta-subunit gene expression. Endocrinology. 2009 May; 150(5):2395-403. PMID: 19106225.
        View in: PubMed
      36. Miller NL, Wevrick R, Mellon P. Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development. Hum Mol Genet. 2009 Jan 15; 18(2):248-60. PMID: 18930956.
        View in: PubMed
      37. Avelino-Cruz JE, Flores A, Cebada J, Mellon P, Felix R, Monjaraz E. Leptin increases L-type Ca2+ channel expression and GnRH-stimulated LH release in LbetaT2 gonadotropes. Mol Cell Endocrinol. 2009 Jan 27; 298(1-2):57-65. PMID: 18834922.
        View in: PubMed
      38. Cherrington BD, Bailey JS, Diaz AL, Mellon P. NeuroD1 and Mash1 temporally regulate GnRH receptor gene expression in immortalized mouse gonadotrope cells. Mol Cell Endocrinol. 2008 Nov 25; 295(1-2):106-14. PMID: 18760324.
        View in: PubMed
      39. Sasson R, Luu SH, Thackray VG, Mellon P. Glucocorticoids induce human glycoprotein hormone alpha-subunit gene expression in the gonadotrope. Endocrinology. 2008 Jul; 149(7):3643-55. PMID: 18403486.
        View in: PubMed
      40. McMahon HE, Hashimoto O, Mellon P, Shimasaki S. Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology. 2008 Jun; 149(6):2807-15. PMID: 18308851.
        View in: PubMed
      41. Thackray VG, Mellon P. Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins. Endocrinology. 2008 Mar; 149(3):1091-102. PMID: 18079204.
        View in: PubMed
      42. Lu M, Tang Q, Olefsky JM, Mellon P, Webster NJ. Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol. 2008 Mar; 22(3):760-71. PMID: 18006641.
        View in: PubMed
      43. Pitteloud N, Zhang C, Pignatelli D, Li JD, Raivio T, Cole LW, Plummer L, Jacobson-Dickman EE, Mellon P, Zhou QY, Crowley WF. Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17447-52. PMID: 17959774.
        View in: PubMed
      44. Coss D, Hand CM, Yaphockun KK, Ely HA, Mellon P. p38 mitogen-activated protein kinase is critical for synergistic induction of the FSH(beta) gene by gonadotropin-releasing hormone and activin through augmentation of c-Fos induction and Smad phosphorylation. Mol Endocrinol. 2007 Dec; 21(12):3071-86. PMID: 17823303.
        View in: PubMed
      45. Lawson MA, Tsutsumi R, Zhang H, Talukdar I, Butler BK, Santos SJ, Mellon P, Webster NJ. Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol. 2007 May; 21(5):1175-91. PMID: 17299135.
        View in: PubMed
      46. Sasson R, Dearth RK, White RS, Chappell PE, Mellon P. Orexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons. Neuroendocrinology. 2006; 84(6):353-63. PMID: 17192702.
        View in: PubMed
      47. McGillivray SM, Thackray VG, Coss D, Mellon P. Activin and glucocorticoids synergistically activate follicle-stimulating hormone beta-subunit gene expression in the immortalized LbetaT2 gonadotrope cell line. Endocrinology. 2007 Feb; 148(2):762-73. PMID: 17082263.
        View in: PubMed
      48. Zhang H, Bailey JS, Coss D, Lin B, Tsutsumi R, Lawson MA, Mellon P, Webster NJ. Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol. 2006 Nov; 20(11):2909-30. PMID: 16772531.
        View in: PubMed
      49. Thackray VG, McGillivray SM, Mellon P. Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotrope. Mol Endocrinol. 2006 Sep; 20(9):2062-79. PMID: 16675544.
        View in: PubMed
      50. Rave-Harel N, Miller NL, Givens ML, Mellon P. The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. J Biol Chem. 2005 Sep 2; 280(35):30975-83. PMID: 16002402.
        View in: PubMed
      51. Tang Q, Mazur M, Mellon P. The protein kinase C pathway acts through multiple transcription factors to repress gonadotropin-releasing hormone gene expression in hypothalamic GT1-7 neuronal cells. Mol Endocrinol. 2005 Nov; 19(11):2769-79. PMID: 15994198.
        View in: PubMed
      52. Coss D, Thackray VG, Deng CX, Mellon P. Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements. Mol Endocrinol. 2005 Oct; 19(10):2610-23. PMID: 15961509.
        View in: PubMed
      53. Givens ML, Rave-Harel N, Goonewardena VD, Kurotani R, Berdy SE, Swan CH, Rubenstein JL, Robert B, Mellon P. Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem. 2005 May 13; 280(19):19156-65. PMID: 15743757.
        View in: PubMed
      54. McGillivray SM, Bailey JS, Ramezani R, Kirkwood BJ, Mellon P. Mouse GnRH receptor gene expression is mediated by the LHX3 homeodomain protein. Endocrinology. 2005 May; 146(5):2180-5. PMID: 15705775.
        View in: PubMed
      55. Givens ML, Kurotani R, Rave-Harel N, Miller NL, Mellon P. Phylogenetic footprinting reveals evolutionarily conserved regions of the gonadotropin-releasing hormone gene that enhance cell-specific expression. Mol Endocrinol. 2004 Dec; 18(12):2950-66. PMID: 15319450.
        View in: PubMed
      56. Rave-Harel N, Givens ML, Nelson SB, Duong HA, Coss D, Clark ME, Hall SB, Kamps MP, Mellon P. TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1. J Biol Chem. 2004 Jul 16; 279(29):30287-97. PMID: 15138251.
        View in: PubMed
      57. Bailey JS, Rave-Harel N, McGillivray SM, Coss D, Mellon P. Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol Endocrinol. 2004 May; 18(5):1158-70. PMID: 14764653.
        View in: PubMed
      58. Spady TJ, Shayya R, Thackray VG, Ehrensberger L, Bailey JS, Mellon P. Androgen regulates follicle-stimulating hormone beta gene expression in an activin-dependent manner in immortalized gonadotropes. Mol Endocrinol. 2004 Apr; 18(4):925-40. PMID: 14701939.
        View in: PubMed
      59. Chappell PE, White RS, Mellon P. Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line. J Neurosci. 2003 Dec 3; 23(35):11202-13. PMID: 14657179.
        View in: PubMed
      60. Coss D, Jacobs SB, Bender CE, Mellon P. A novel AP-1 site is critical for maximal induction of the follicle-stimulating hormone beta gene by gonadotropin-releasing hormone. J Biol Chem. 2004 Jan 2; 279(1):152-62. PMID: 14570911.
        View in: PubMed
      61. Pernasetti F, Spady TJ, Hall SB, Rosenberg SB, Givens ML, Anderson S, Paulus M, Miller WL, Mellon P. Pituitary tumorigenesis targeted by the ovine follicle-stimulating hormone beta-subunit gene regulatory region in transgenic mice. Mol Cell Endocrinol. 2003 May 30; 203(1-2):169-83. PMID: 12782413.
        View in: PubMed
      62. Jacobs SB, Coss D, McGillivray SM, Mellon P. Nuclear factor Y and steroidogenic factor 1 physically and functionally interact to contribute to cell-specific expression of the mouse Follicle-stimulating hormone-beta gene. Mol Endocrinol. 2003 Aug; 17(8):1470-83. PMID: 12730328.
        View in: PubMed
      63. Kelley CG, Givens ML, Rave-Harel N, Nelson SB, Anderson S, Mellon P. Neuron-restricted expression of the rat gonadotropin-releasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elements. Mol Endocrinol. 2002 Nov; 16(11):2413-25. PMID: 12403831.
        View in: PubMed
      64. Vasilyev VV, Lawson MA, Dipaolo D, Webster NJ, Mellon P. Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology. 2002 Sep; 143(9):3414-26. PMID: 12193554.
        View in: PubMed
      65. Arroyo A, Pernasetti F, Vasilyev VV, Amato P, Yen SS, Mellon P. A unique case of combined pituitary hormone deficiency caused by a PROP1 gene mutation (R120C) associated with normal height and absent puberty. Clin Endocrinol (Oxf). 2002 Aug; 57(2):283-91. PMID: 12153609.
        View in: PubMed
      66. Liu F, Usui I, Evans LG, Austin DA, Mellon P, Olefsky JM, Webster NJ. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem. 2002 Aug 30; 277(35):32099-108. PMID: 12050161.
        View in: PubMed
      67. Rosenberg SB, Mellon P. An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation. Mol Endocrinol. 2002 Jun; 16(6):1280-98. PMID: 12040015.
        View in: PubMed
      68. Vasilyev VV, Pernasetti F, Rosenberg SB, Barsoum MJ, Austin DA, Webster NJ, Mellon P. Transcriptional activation of the ovine follicle-stimulating hormone-beta gene by gonadotropin-releasing hormone involves multiple signal transduction pathways. Endocrinology. 2002 May; 143(5):1651-9. PMID: 11956146.
        View in: PubMed
      69. Holley SJ, Hall SB, Mellon P. Complementary expression of IGF-II and IGFBP-5 during anterior pituitary development. Dev Biol. 2002 Apr 15; 244(2):319-28. PMID: 11944940.
        View in: PubMed
      70. Lawson MA, Macconell LA, Kim J, Powl BT, Nelson SB, Mellon P. Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH gene. Endocrinology. 2002 Apr; 143(4):1404-12. PMID: 11897697.
        View in: PubMed
      71. Amato P, Christophe S, Mellon P. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause. 2002 Mar-Apr; 9(2):145-50. PMID: 11875334.
        View in: PubMed
      72. Liu F, Austin DA, Mellon P, Olefsky JM, Webster NJ. GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol. 2002 Mar; 16(3):419-34. PMID: 11875099.
        View in: PubMed
      73. Pernasetti F, Vasilyev VV, Rosenberg SB, Bailey JS, Huang HJ, Miller WL, Mellon P. Cell-Specific Transcriptional Regulation of Follicle-Stimulating Hormone-ß by Activin and Gonadotropin-Releasing Hormone in the LßT2 Pituitary Gonadotrope Cell Model. Endocrinology. 2001 Jun 01; 142(6):2284-2295. PMID: 28201511.
        View in: PubMed
      74. Pernasetti F, Vasilyev VV, Rosenberg SB, Bailey JS, Huang HJ, Miller WL, Mellon P. Cell-specific transcriptional regulation of follicle-stimulating hormone-beta by activin and gonadotropin-releasing hormone in the LbetaT2 pituitary gonadotrope cell model. Endocrinology. 2001 Jun; 142(6):2284-95. PMID: 11356674.
        View in: PubMed
      75. Dardick I, Ho J, Paulus M, Mellon P, Mirels L. Submandibular gland adenocarcinoma of intercalated duct origin in Smgb-Tag mice. Lab Invest. 2000 Nov; 80(11):1657-70. PMID: 11092526.
        View in: PubMed
      76. Sosnowski R, Mellon P, Lawson MA. Activation of translation in pituitary gonadotrope cells by gonadotropin-releasing hormone. Mol Endocrinol. 2000 Nov; 14(11):1811-9. PMID: 11075814.
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      77. Nelson SB, Lawson MA, Kelley CG, Mellon P. Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells. Mol Endocrinol. 2000 Sep; 14(9):1509-22. PMID: 10976927.
        View in: PubMed
      78. Kelley CG, Lavorgna G, Clark ME, Boncinelli E, Mellon P. The Otx2 homeoprotein regulates expression from the gonadotropin-releasing hormone proximal promoter. Mol Endocrinol. 2000 Aug; 14(8):1246-56. PMID: 10935548.
        View in: PubMed
      79. LiCalsi C, Christophe S, Steger DJ, Buescher M, Fischer W, Mellon P. AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin. Nucleic Acids Res. 2000 Feb 15; 28(4):1036-43. PMID: 10648798.
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      80. Belsham DD, Mellon P. Transcription factors Oct-1 and C/EBPbeta (CCAAT/enhancer-binding protein-beta) are involved in the glutamate/nitric oxide/cyclic-guanosine 5'-monophosphate-mediated repression of mediated repression of gonadotropin-releasing hormone gene expression. Mol Endocrinol. 2000 Feb; 14(2):212-28. PMID: 10674395.
        View in: PubMed
      81. Pernasetti F, Toledo SP, Vasilyev VV, Hayashida CY, Cogan JD, Ferrari C, Lourenço DM, Mellon P. Impaired adrenocorticotropin-adrenal axis in combined pituitary hormone deficiency caused by a two-base pair deletion (301-302delAG) in the prophet of Pit-1 gene. J Clin Endocrinol Metab. 2000 Jan; 85(1):390-7. PMID: 10634415.
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      82. Anderson RA, Zwain IH, Arroyo A, Mellon P, Yen SS. The insulin-like growth factor system in the GT1-7 GnRH neuronal cell line. Neuroendocrinology. 1999 Nov; 70(5):353-9. PMID: 10567861.
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      83. MacConell LA, Lawson MA, Mellon P, Roberts VJ. Activin A regulation of gonadotropin-releasing hormone synthesis and release in vitro. Neuroendocrinology. 1999 Oct; 70(4):246-54. PMID: 10529619.
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      84. Kurotani R, Tahara S, Sanno N, Teramoto A, Mellon P, Inoue K, Yoshimura S, Osamura RY. Expression of Ptx1 in the adult rat pituitary glands and pituitary cell lines: hormone-secreting cells and folliculo-stellate cells. Cell Tissue Res. 1999 Oct; 298(1):55-61. PMID: 10555539.
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      85. Kurotani R, Tahara S, Sanno N, Teramoto A, Mellon P, Inoue K, Yoshimura S, Osamura RY. Expression of ptx1 in the adult rat pituitary glands and pituitary cell lines: hormone-secreting cells and folliculo-stellate cells Cell Tissue Res. 1999 Oct; 298(1):55-61. PMID: 10502117.
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      86. Yusta B, Alarid ET, Gordon DF, Ridgway EC, Mellon P. The Thyrotropin ß-Subunit Gene Is Repressed by Thyroid Hormone in a Novel Thyrotrope Cell Line, Mouse TaT1 Cells* *This work was supported by NIH Research Grants R01-HD-20377 and HD-12303 (to P.L.M.) and R01-DK-36843 (to E.C.R.); fellowships from the Spanish Ministry of Education and Science and Fundacion Jaime del Amo, Universidad Complutense de Madrid, Spain (to B.Y.); and a Ford Foundation Fellowship, the President's Fellowship of the University of California, and NIH National Research Scientist Award Fellowship DK-09145 (to E.T.A.). Endocrinology. 1998 Nov 01; 139(11):4476-4482. PMID: 28200393.
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      87. Yusta B, Alarid ET, Gordon DF, Ridgway EC, Mellon P. The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells. Endocrinology. 1998 Nov; 139(11):4476-82. PMID: 9794455.
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      88. Lawson MA, Mellon P. Expression of GATA-4 in migrating gonadotropin-releasing neurons of the developing mouse. Mol Cell Endocrinol. 1998 May 25; 140(1-2):157-61. PMID: 9722184.
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      89. Alarid ET, Holley S, Hayakawa M, Mellon P. Discrete stages of anterior pituitary differentiation recapitulated in immortalized cell lines. Mol Cell Endocrinol. 1998 May 25; 140(1-2):25-30. PMID: 9722164.
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      90. Nelson SB, Eraly SA, Mellon P. The GnRH promoter: target of transcription factors, hormones, and signaling pathways. Mol Cell Endocrinol. 1998 May 25; 140(1-2):151-5. PMID: 9722183.
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      91. Harris AN, Mellon P. The basic helix-loop-helix, leucine zipper transcription factor, USF (upstream stimulatory factor), is a key regulator of SF-1 (steroidogenic factor-1) gene expression in pituitary gonadotrope and steroidogenic cells. Mol Endocrinol. 1998 May; 12(5):714-26. PMID: 9605934.
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      92. Eraly SA, Nelson SB, Huang KM, Mellon P. Oct-1 binds promoter elements required for transcription of the GnRH gene. Mol Endocrinol. 1998 Apr; 12(4):469-81. PMID: 9544983.
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      93. Lawson MA, Buhain AR, Jovenal JC, Mellon P. Multiple factors interacting at the GATA sites of the gonadotropin-releasing hormone neuron-specific enhancer regulate gene expression. Mol Endocrinol. 1998 Mar; 12(3):364-77. PMID: 9514154.
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      94. Alarid ET, Windle JJ, Whyte DB, Mellon P. Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice. Development. 1996 Oct; 122(10):3319-29. PMID: 8898243.
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      95. Thomas P, Mellon P, Turgeon J, Waring DW. The L beta T2 clonal gonadotrope: a model for single cell studies of endocrine cell secretion. Endocrinology. 1996 Jul; 137(7):2979-89. PMID: 8770922.
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      96. Lawson MA, Whyte DB, Mellon P. GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene. Mol Cell Biol. 1996 Jul; 16(7):3596-605. PMID: 8668176.
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      97. Turgeon JL, Kimura Y, Waring DW, Mellon P. Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell line. Mol Endocrinol. 1996 Apr; 10(4):439-50. PMID: 8721988.
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      98. Belsham DD, Wetsel WC, Mellon P. NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. EMBO J. 1996 Feb 1; 15(3):538-47. PMID: 8599937.
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      99. Clark ME, Mellon P. The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer. Mol Cell Biol. 1995 Nov; 15(11):6169-77. PMID: 7565769.
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      100. Ben-Menahem D, Shraga-Levine Z, Mellon P, Naor Z. Mechanism of action of gonadotropin-releasing hormone upon gonadotropin alpha-subunit mRNA levels in the alpha T3-1 cell line: role of Ca2+ and protein kinase C. Biochem J. 1995 Jul 1; 309 ( Pt 1):325-9. PMID: 7542447.
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      101. Eraly SA, Mellon P. Regulation of gonadotropin-releasing hormone transcription by protein kinase C is mediated by evolutionarily conserved promoter-proximal elements. Mol Endocrinol. 1995 Jul; 9(7):848-59. PMID: 7476968.
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      102. Schechter J, Stauber C, Windle JJ, Mellon P. Basic fibroblast growth factor: the neurotrophic factor influencing the ingrowth of neural tissue into the anterior pituitary of alpha-T7 transgenic mice? Neuroendocrinology. 1995 Jun; 61(6):622-7. PMID: 7659188.
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      103. Alarid ET, Mellon P. Down-regulation of the gonadotropin-releasing hormone receptor messenger ribonucleic acid by activation of adenylyl cyclase in alpha T3-1 pituitary gonadotrope cells. Endocrinology. 1995 Apr; 136(4):1361-6. PMID: 7895646.
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      104. Whyte DB, Lawson MA, Belsham DD, Eraly SA, Bond CT, Adelman JP, Mellon P. A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons. Mol Endocrinol. 1995 Apr; 9(4):467-77. PMID: 7659090.
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      105. Lawson MA, Whyte DB, Eraly SA, Mellon P. Hypothalamus-specific regulation of gonadotropin-releasing hormone gene expression. Recent Prog Horm Res. 1995; 50:459-63. PMID: 7740182.
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