Karen Tonsfeldt

Title(s)Assistant Project Scientist, Ob/Gyn & Reproductive sciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-8044-8857 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Oregon State University, Corvallis, ORBS06/2008Zoology
    Oregon State University, Corvallis, ORBS06/2008Psychology
    Oregon Health and Science University, Portland, ORPhD09/2014Neuroscience

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of the preovulatory surge by the suprachiasmatic nucleus
    NIH/NICHD F32HD090837Jul 1, 2017 - Jun 30, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms. JCI Insight. 2023 02 08; 8(3). Cassin J, Stamou MI, Keefe KW, Sung KE, Bojo CC, Tonsfeldt KJ, Rojas RA, Ferreira Lopes V, Plummer L, Salnikov KB, Keefe DL, Ozata M, Genel M, Georgopoulos NA, Hall JE, Crowley WF, Seminara SB, Mellon PL, Balasubramanian R. PMID: 36602867; PMCID: PMC9977424.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Physiological Responses and Training Satisfaction During National Rollout of a Neurosurgical Intraoperative Catastrophe Simulator for Resident Training. Oper Neurosurg (Hagerstown). 2023 Jan 01; 24(1):80-87. Siler DA, Cleary DR, Tonsfeldt KJ, Wali AR, Hinson HE, Khalessi AA, Selden NR. PMID: 36519881.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Female fertility does not require Bmal1 in suprachiasmatic nucleus neurons expressing arginine vasopressin, vasoactive intestinal peptide, or neuromedin-S. Front Endocrinol (Lausanne). 2022; 13:956169. Tonsfeldt KJ, Cui LJ, Lee J, Walbeek TJ, Brusman LE, Jin Y, Mieda M, Gorman MR, Mellon PL. PMID: 35992114; PMCID: PMC9389073.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Scalable Thousand Channel Penetrating Microneedle Arrays on Flex for Multimodal and Large Area Coverage BrainMachine Interfaces. Adv Funct Mater. 2022 Jun 17; 32(25). Lee SH, Thunemann M, Lee K, Cleary DR, Tonsfeldt KJ, Oh H, Azzazy F, Tchoe Y, Bourhis AM, Hossain L, Ro YG, Tanaka A, Kiliç K, Devor A, Dayeh SA. PMID: 36381629; PMCID: PMC9648634.
      View in: PubMed   Mentions: 12  
    5. Deletion of the homeodomain gene Six3 from kisspeptin neurons causes subfertility in female mice. Mol Cell Endocrinol. 2022 04 15; 546:111577. Lavalle SN, Chou T, Hernandez J, Naing NCP, He MY, Tonsfeldt KJ, Mellon PL. PMID: 35121076; PMCID: PMC8934285.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Circadian Rhythms in the Neuronal Network Timing the Luteinizing Hormone Surge. Endocrinology. 2022 02 01; 163(2). Tonsfeldt KJ, Mellon PL, Hoffmann HM. PMID: 34967900; PMCID: PMC8782605.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    7. Human brain mapping with multithousand-channel PtNRGrids resolves spatiotemporal dynamics. Sci Transl Med. 2022 01 19; 14(628):eabj1441. Tchoe Y, Bourhis AM, Cleary DR, Stedelin B, Lee J, Tonsfeldt KJ, Brown EC, Siler DA, Paulk AC, Yang JC, Oh H, Ro YG, Lee K, Russman SM, Ganji M, Galton I, Ben-Haim S, Raslan AM, Dayeh SA. PMID: 35044788; PMCID: PMC9650779.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    8. Considerations and recent advances in nanoscale interfaces with neuronal and cardiac networks. Appl Phys Rev. 2021 Dec; 8(4):041317. Tchoe Y, Lee J, Liu R, Bourhis AM, Vatsyayan R, Tonsfeldt KJ, Dayeh SA. PMID: 34868443; PMCID: PMC8596389.
      View in: PubMed   Mentions: 2  
    9. Reproductive Deficits Induced by Prenatal Antimüllerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells. Endocrinology. 2021 12 01; 162(12). Ho EV, Shi C, Cassin J, He MY, Nguyen RD, Ryan GE, Tonsfeldt KJ, Mellon PL. PMID: 34529765; PMCID: PMC8507963.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    10. Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks. Adv Funct Mater. 2022 Feb 16; 32(8). Liu R, Lee J, Tchoe Y, Pre D, Bourhis AM, D'Antonio-Chronowska A, Robin G, Lee SH, Ro YG, Vatsyayan R, Tonsfeldt KJ, Hossain LA, Phipps ML, Yoo J, Nogan J, Martinez JS, Frazer KA, Bang AG, Dayeh SA. PMID: 35603230; PMCID: PMC9122115.
      View in: PubMed   Mentions: 7  
    11. The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice. J Neurosci Res. 2021 10; 99(10):2625-2645. Hoffmann HM, Meadows JD, Breuer JA, Yaw AM, Nguyen D, Tonsfeldt KJ, Chin AY, Devries BM, Trang C, Oosterhouse HJ, Lee JS, Doser JW, Gorman MR, Welsh DK, Mellon PL. PMID: 34212416; PMCID: PMC8577618.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Kiss1 is differentially regulated in male and female mice by the homeodomain transcription factor VAX1. Mol Cell Endocrinol. 2021 08 20; 534:111358. Lavalle SN, Chou T, Hernandez J, Naing NCP, Tonsfeldt KJ, Hoffmann HM, Mellon PL. PMID: 34098016; PMCID: PMC8319105.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. Growth Hormone Pulses and Liver Gene Expression Are Differentially Regulated by the Circadian Clock Gene Bmal1. Endocrinology. 2021 04 01; 162(4). Schoeller EL, Tonsfeldt KJ, Sinkovich M, Shi R, Mellon PL. PMID: 33539533; PMCID: PMC7901660.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    14. GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes. Sci Rep. 2020 08 03; 10(1):13063. Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SBZ, Trejo J, Kauffman AS, Mellon PL, Lawson MA. PMID: 32747664; PMCID: PMC7400764.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. Deletion of the Homeodomain Protein Six6 From GnRH Neurons Decreases GnRH Gene Expression, Resulting in Infertility. Endocrinology. 2019 09 01; 160(9):2151-2164. Pandolfi EC, Tonsfeldt KJ, Hoffmann HM, Mellon PL. PMID: 31211355; PMCID: PMC6821215.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    16. The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge. J Endocr Soc. 2019 Apr 01; 3(4):716-733. Tonsfeldt KJ, Schoeller EL, Brusman LE, Cui LJ, Lee J, Mellon PL. PMID: 30906911; PMCID: PMC6425515.
      View in: PubMed   Mentions: 17  
    17. A possible neural mechanism for photosensitivity in chronic pain. Pain. 2016 Apr; 157(4):868-878. Martenson ME, Halawa OI, Tonsfeldt KJ, Maxwell CA, Hammack N, Mist SD, Pennesi ME, Bennett RM, Mauer KM, Jones KD, Heinricher MM. PMID: 26785323; PMCID: PMC4794405.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    18. Sex Differences in GABAA Signaling in the Periaqueductal Gray Induced by Persistent Inflammation. J Neurosci. 2016 Feb 03; 36(5):1669-81. Tonsfeldt KJ, Suchland KL, Beeson KA, Lowe JD, Li MH, Ingram SL. PMID: 26843648; PMCID: PMC4737776.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    19. Molecular mechanisms that drive estradiol-dependent burst firing of Kiss1 neurons in the rostral periventricular preoptic area. Am J Physiol Endocrinol Metab. 2013 Dec 01; 305(11):E1384-97. Zhang C, Tonsfeldt KJ, Qiu J, Bosch MA, Kobayashi K, Steiner RA, Kelly MJ, Rønnekleiv OK. PMID: 24105416; PMCID: PMC3882370.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    20. mRNA expression of ion channels in GnRH neurons: subtype-specific regulation by 17β-estradiol. Mol Cell Endocrinol. 2013 Mar 10; 367(1-2):85-97. Bosch MA, Tonsfeldt KJ, Rønnekleiv OK. PMID: 23305677; PMCID: PMC3570747.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    21. Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinology. 2011 Nov; 152(11):4298-309. Gottsch ML, Popa SM, Lawhorn JK, Qiu J, Tonsfeldt KJ, Bosch MA, Kelly MJ, Rønnekleiv OK, Sanz E, McKnight GS, Clifton DK, Palmiter RD, Steiner RA. PMID: 21933870; PMCID: PMC3199004.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    22. Oestrogen induces rhythmic expression of the Kisspeptin-1 receptor GPR54 in hypothalamic gonadotrophin-releasing hormone-secreting GT1-7 cells. J Neuroendocrinol. 2011 Sep; 23(9):823-30. Tonsfeldt KJ, Goodall CP, Latham KL, Chappell PE. PMID: 21756268; PMCID: PMC3243730.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    23. Clocks on top: the role of the circadian clock in the hypothalamic and pituitary regulation of endocrine physiology. Mol Cell Endocrinol. 2012 Feb 05; 349(1):3-12. Tonsfeldt KJ, Chappell PE. PMID: 21787834; PMCID: PMC3242828.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    24. Differential localization of vesicular glutamate transporters and peptides in corneal afferents to trigeminal nucleus caudalis. J Comp Neurol. 2010 Sep 01; 518(17):3557-69. Hegarty DM, Tonsfeldt K, Hermes SM, Helfand H, Aicher SA. PMID: 20593358; PMCID: PMC2933108.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    25. Modulation of gonadotrophin-releasing hormone secretion by an endogenous circadian clock. J Neuroendocrinol. 2009 Mar; 21(4):339-45. Chappell PE, Goodall CP, Tonsfeldt KJ, White RS, Bredeweg E, Latham KL. PMID: 19187466.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
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