Karen Tonsfeldt

Title(s)	Assistant Project Scientist, Ob/Gyn & Reproductive sciences
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
ORCID	0000-0001-8044-8857
vCard	Download vCard

Biography

Education and Training

Oregon State University, Corvallis, OR	BS	06/2008	Zoology
Oregon State University, Corvallis, OR	BS	06/2008	Psychology
Oregon Health and Science University, Portland, OR	PhD	09/2014	Neuroscience

Research

Research Activities and Funding

Regulation of the preovulatory surge by the suprachiasmatic nucleus
NIH/NICHD F32HD090837Jul 1, 2017 - Jun 30, 2019
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms. JCI Insight. 2023 02 08; 8(3). Cassin J, Stamou MI, Keefe KW, Sung KE, Bojo CC, Tonsfeldt KJ, Rojas RA, Ferreira Lopes V, Plummer L, Salnikov KB, Keefe DL, Ozata M, Genel M, Georgopoulos NA, Hall JE, Crowley WF, Seminara SB, Mellon PL, Balasubramanian R. PMID: 36602867; PMCID: PMC9977424.

View in: PubMed Mentions: Fields:
Med Medicine (General)
Translation:Humans Animals
Physiological Responses and Training Satisfaction During National Rollout of a Neurosurgical Intraoperative Catastrophe Simulator for Resident Training. Oper Neurosurg (Hagerstown). 2023 Jan 01; 24(1):80-87. Siler DA, Cleary DR, Tonsfeldt KJ, Wali AR, Hinson HE, Khalessi AA, Selden NR. PMID: 36519881.

View in: PubMed Mentions: 1 Fields:
Neu Neurosurgery
Female fertility does not require Bmal1 in suprachiasmatic nucleus neurons expressing arginine vasopressin, vasoactive intestinal peptide, or neuromedin-S. Front Endocrinol (Lausanne). 2022; 13:956169. Tonsfeldt KJ, Cui LJ, Lee J, Walbeek TJ, Brusman LE, Jin Y, Mieda M, Gorman MR, Mellon PL. PMID: 35992114; PMCID: PMC9389073.

View in: PubMed Mentions: 1 Fields:
End Endocrinology
Translation:Animals Cells
Scalable Thousand Channel Penetrating Microneedle Arrays on Flex for Multimodal and Large Area Coverage BrainMachine Interfaces. Adv Funct Mater. 2022 Jun 17; 32(25). Lee SH, Thunemann M, Lee K, Cleary DR, Tonsfeldt KJ, Oh H, Azzazy F, Tchoe Y, Bourhis AM, Hossain L, Ro YG, Tanaka A, Kiliç K, Devor A, Dayeh SA. PMID: 36381629; PMCID: PMC9648634.

View in: PubMed Mentions: 8
Deletion of the homeodomain gene Six3 from kisspeptin neurons causes subfertility in female mice. Mol Cell Endocrinol. 2022 04 15; 546:111577. Lavalle SN, Chou T, Hernandez J, Naing NCP, He MY, Tonsfeldt KJ, Mellon PL. PMID: 35121076; PMCID: PMC8934285.

View in: PubMed Mentions: Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Circadian Rhythms in the Neuronal Network Timing the Luteinizing Hormone Surge. Endocrinology. 2022 02 01; 163(2). Tonsfeldt KJ, Mellon PL, Hoffmann HM. PMID: 34967900; PMCID: PMC8782605.

View in: PubMed Mentions: 5 Fields:
End Endocrinology
Translation:Animals Cells
Human brain mapping with multithousand-channel PtNRGrids resolves spatiotemporal dynamics. Sci Transl Med. 2022 01 19; 14(628):eabj1441. Tchoe Y, Bourhis AM, Cleary DR, Stedelin B, Lee J, Tonsfeldt KJ, Brown EC, Siler DA, Paulk AC, Yang JC, Oh H, Ro YG, Lee K, Russman SM, Ganji M, Galton I, Ben-Haim S, Raslan AM, Dayeh SA. PMID: 35044788; PMCID: PMC9650779.

View in: PubMed Mentions: 17 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals
Reproductive Deficits Induced by Prenatal Antimüllerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells. Endocrinology. 2021 12 01; 162(12). Ho EV, Shi C, Cassin J, He MY, Nguyen RD, Ryan GE, Tonsfeldt KJ, Mellon PL. PMID: 34529765; PMCID: PMC8507963.

View in: PubMed Mentions: 5 Fields:
End Endocrinology
Translation:Animals
Considerations and recent advances in nanoscale interfaces with neuronal and cardiac networks. Appl Phys Rev. 2021 Dec; 8(4):041317. Tchoe Y, Lee J, Liu R, Bourhis AM, Vatsyayan R, Tonsfeldt KJ, Dayeh SA. PMID: 34868443; PMCID: PMC8596389.

View in: PubMed Mentions: 2
Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks. Adv Funct Mater. 2022 Feb 16; 32(8). Liu R, Lee J, Tchoe Y, Pre D, Bourhis AM, D'Antonio-Chronowska A, Robin G, Lee SH, Ro YG, Vatsyayan R, Tonsfeldt KJ, Hossain LA, Phipps ML, Yoo J, Nogan J, Martinez JS, Frazer KA, Bang AG, Dayeh SA. PMID: 35603230; PMCID: PMC9122115.

View in: PubMed Mentions: 7
The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice. J Neurosci Res. 2021 10; 99(10):2625-2645. Hoffmann HM, Meadows JD, Breuer JA, Yaw AM, Nguyen D, Tonsfeldt KJ, Chin AY, Devries BM, Trang C, Oosterhouse HJ, Lee JS, Doser JW, Gorman MR, Welsh DK, Mellon PL. PMID: 34212416; PMCID: PMC8577618.

View in: PubMed Mentions: 7 Fields:
Neu Neurology
Translation:Animals Cells
Kiss1 is differentially regulated in male and female mice by the homeodomain transcription factor VAX1. Mol Cell Endocrinol. 2021 08 20; 534:111358. Lavalle SN, Chou T, Hernandez J, Naing NCP, Tonsfeldt KJ, Hoffmann HM, Mellon PL. PMID: 34098016; PMCID: PMC8319105.

View in: PubMed Mentions: 4 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Humans Animals Cells
Growth Hormone Pulses and Liver Gene Expression Are Differentially Regulated by the Circadian Clock Gene Bmal1. Endocrinology. 2021 04 01; 162(4). Schoeller EL, Tonsfeldt KJ, Sinkovich M, Shi R, Mellon PL. PMID: 33539533; PMCID: PMC7901660.

View in: PubMed Mentions: 4 Fields:
End Endocrinology
Translation:Animals
GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes. Sci Rep. 2020 08 03; 10(1):13063. Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SBZ, Trejo J, Kauffman AS, Mellon PL, Lawson MA. PMID: 32747664; PMCID: PMC7400764.

View in: PubMed Mentions: 2 Fields:
Sci Science
Translation:Animals Cells
Deletion of the Homeodomain Protein Six6 From GnRH Neurons Decreases GnRH Gene Expression, Resulting in Infertility. Endocrinology. 2019 09 01; 160(9):2151-2164. Pandolfi EC, Tonsfeldt KJ, Hoffmann HM, Mellon PL. PMID: 31211355; PMCID: PMC6821215.

View in: PubMed Mentions: 6 Fields:
End Endocrinology
Translation:Animals
The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge. J Endocr Soc. 2019 Apr 01; 3(4):716-733. Tonsfeldt KJ, Schoeller EL, Brusman LE, Cui LJ, Lee J, Mellon PL. PMID: 30906911; PMCID: PMC6425515.

View in: PubMed Mentions: 16
A possible neural mechanism for photosensitivity in chronic pain. Pain. 2016 Apr; 157(4):868-878. Martenson ME, Halawa OI, Tonsfeldt KJ, Maxwell CA, Hammack N, Mist SD, Pennesi ME, Bennett RM, Mauer KM, Jones KD, Heinricher MM. PMID: 26785323; PMCID: PMC4794405.

View in: PubMed Mentions: 25 Fields:
Neu Neurology Psy Psychophysiology
Translation:Humans Cells
Sex Differences in GABAA Signaling in the Periaqueductal Gray Induced by Persistent Inflammation. J Neurosci. 2016 Feb 03; 36(5):1669-81. Tonsfeldt KJ, Suchland KL, Beeson KA, Lowe JD, Li MH, Ingram SL. PMID: 26843648; PMCID: PMC4737776.

View in: PubMed Mentions: 29 Fields:
Neu Neurology
Translation:Animals Cells
Molecular mechanisms that drive estradiol-dependent burst firing of Kiss1 neurons in the rostral periventricular preoptic area. Am J Physiol Endocrinol Metab. 2013 Dec 01; 305(11):E1384-97. Zhang C, Tonsfeldt KJ, Qiu J, Bosch MA, Kobayashi K, Steiner RA, Kelly MJ, Rønnekleiv OK. PMID: 24105416; PMCID: PMC3882370.

View in: PubMed Mentions: 39 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals Cells
mRNA expression of ion channels in GnRH neurons: subtype-specific regulation by 17β-estradiol. Mol Cell Endocrinol. 2013 Mar 10; 367(1-2):85-97. Bosch MA, Tonsfeldt KJ, Rønnekleiv OK. PMID: 23305677; PMCID: PMC3570747.

View in: PubMed Mentions: 58 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinology. 2011 Nov; 152(11):4298-309. Gottsch ML, Popa SM, Lawhorn JK, Qiu J, Tonsfeldt KJ, Bosch MA, Kelly MJ, Rønnekleiv OK, Sanz E, McKnight GS, Clifton DK, Palmiter RD, Steiner RA. PMID: 21933870; PMCID: PMC3199004.

View in: PubMed Mentions: 75 Fields:
End Endocrinology
Translation:Animals Cells
Oestrogen induces rhythmic expression of the Kisspeptin-1 receptor GPR54 in hypothalamic gonadotrophin-releasing hormone-secreting GT1-7 cells. J Neuroendocrinol. 2011 Sep; 23(9):823-30. Tonsfeldt KJ, Goodall CP, Latham KL, Chappell PE. PMID: 21756268; PMCID: PMC3243730.

View in: PubMed Mentions: 22 Fields:
End Endocrinology Neu Neurology
Translation:Animals Cells
Clocks on top: the role of the circadian clock in the hypothalamic and pituitary regulation of endocrine physiology. Mol Cell Endocrinol. 2012 Feb 05; 349(1):3-12. Tonsfeldt KJ, Chappell PE. PMID: 21787834; PMCID: PMC3242828.

View in: PubMed Mentions: 20 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Humans Animals
Differential localization of vesicular glutamate transporters and peptides in corneal afferents to trigeminal nucleus caudalis. J Comp Neurol. 2010 Sep 01; 518(17):3557-69. Hegarty DM, Tonsfeldt K, Hermes SM, Helfand H, Aicher SA. PMID: 20593358; PMCID: PMC2933108.

View in: PubMed Mentions: 29 Fields:
Neu Neurology
Translation:Animals Cells
Modulation of gonadotrophin-releasing hormone secretion by an endogenous circadian clock. J Neuroendocrinol. 2009 Mar; 21(4):339-45. Chappell PE, Goodall CP, Tonsfeldt KJ, White RS, Bredeweg E, Latham KL. PMID: 19187466.

View in: PubMed Mentions: 10 Fields:
End Endocrinology Neu Neurology
Translation:Animals Cells