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Hatim Husain

Title(s)Associate Clinical Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0987
La Jolla CA 92093
Phone858-822-6135
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    Johns Hopkins University, Baltimore, MDMedical Oncology
    University of Southern California, Los Angeles, CAInternal Medicine
    Northwestern University, Chicago, ILDoctor of Medicine

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    Role Description: I am a lung cancer medical oncologist at UCSD Moores Cancer Center pursuing a translational career in cancer therapeutic strategies in solid tumor malignancies. My passion is be involved in early drug development and my goal is to develop a translational laboratory for biomarker validation and drug testing in in vitro and in in vivo models that can form the basis for early phase clinical trials. I work very closely to characterize technology development in the circulating tumor DNA space and applications about its utility. Recent work has also involved in understanding mechanisms of resistance to anti-EGFR directed therapies and further understanding the mechanisms of immunogenic cell death in cancer cells.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Applications of cell-free circulating tumor DNA detection in EGFR mutant lung cancer. J Thorac Dis. 2020 May; 12(5):2877-2882. Bulbul A, Leal A, Husain H. PMID: 32642200.
      View in: PubMed   Mentions:
    2. Assessing tumor heterogeneity using ctDNA to predict and monitor therapeutic response in metastatic breast cancer. Int J Cancer. 2020 03 01; 146(5):1359-1368. Ma F, Guan Y, Yi Z, Chang L, Li Q, Chen S, Zhu W, Guan X, Li C, Qian H, Xia X, Yang L, Zhang J, Husain H, Liao Z, Futreal A, Huang J, Yi X, Xu B. PMID: 31241775.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    3. Genome-wide cell-free DNA fragmentation in patients with cancer. Nature. 2019 06; 570(7761):385-389. Cristiano S, Leal A, Phallen J, Fiksel J, Adleff V, Bruhm DC, Jensen SØ, Medina JE, Hruban C, White JR, Palsgrove DN, Niknafs N, Anagnostou V, Forde P, Naidoo J, Marrone K, Brahmer J, Woodward BD, Husain H, van Rooijen KL, Ørntoft MW, Madsen AH, van de Velde CJH, Verheij M, Cats A, Punt CJA, Vink GR, van Grieken NCT, Koopman M, Fijneman RJA, Johansen JS, Nielsen HJ, Meijer GA, Andersen CL, Scharpf RB, Velculescu VE. PMID: 31142840.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    4. Circulating tumor DNA analyses predict progressive disease and indicate trastuzumab-resistant mechanism in advanced gastric cancer. EBioMedicine. 2019 May; 43:261-269. Wang Y, Zhao C, Chang L, Jia R, Liu R, Zhang Y, Gao X, Li J, Chen R, Xia X, Bulbul A, Husain H, Guan Y, Yi X, Xu J. PMID: 31031019.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Novel Third-Generation EGFR Tyrosine Kinase Inhibitors and Strategies to Overcome Therapeutic Resistance in Lung Cancer. Cancer Res. 2019 02 15; 79(4):689-698. Murtuza A, Bulbul A, Shen JP, Keshavarzian P, Woodward BD, Lopez-Diaz FJ, Lippman SM, Husain H. PMID: 30718357.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    6. Early Noninvasive Detection of Response to Targeted Therapy in Non-Small Cell Lung Cancer. Cancer Res. 2019 03 15; 79(6):1204-1213. Phallen J, Leal A, Woodward BD, Forde PM, Naidoo J, Marrone KA, Brahmer JR, Fiksel J, Medina JE, Cristiano S, Palsgrove DN, Gocke CD, Bruhm DC, Keshavarzian P, Adleff V, Weihe E, Anagnostou V, Scharpf RB, Velculescu VE, Husain H. PMID: 30573519.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    7. EGFR-Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes. J Clin Oncol. 2019 02 01; 37(4):278-285. Marcoux N, Gettinger SN, O'Kane G, Arbour KC, Neal JW, Husain H, Evans TL, Brahmer JR, Muzikansky A, Bonomi PD, Del Prete S, Wurtz A, Farago AF, Dias-Santagata D, Mino-Kenudson M, Reckamp KL, Yu HA, Wakelee HA, Shepherd FA, Piotrowska Z, Sequist LV. PMID: 30550363.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    8. Assessment of Resistance Mechanisms and Clinical Implications in Patients With EGFR T790M-Positive Lung Cancer and Acquired Resistance to Osimertinib. JAMA Oncol. 2018 11 01; 4(11):1527-1534. Oxnard GR, Hu Y, Mileham KF, Husain H, Costa DB, Tracy P, Feeney N, Sholl LM, Dahlberg SE, Redig AJ, Kwiatkowski DJ, Rabin MS, Paweletz CP, Thress KS, Jänne PA. PMID: 30073261.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    9. Systemic Treatment Options for Brain Metastases from Non-Small-Cell Lung Cancer. Oncology (Williston Park). 2018 04 15; 32(4):156-63. Bulbul A, Forde PM, Murtuza A, Woodward B, Yang H, Bastian I, Ferguson PK, Lopez-Diaz F, Ettinger DS, Husain H. PMID: 29684234.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. First-Line Treatment in EGFR Mutant Non-Small Cell Lung Cancer: Is There a Best Option? Front Oncol. 2018; 8:94. Bulbul A, Husain H. PMID: 29755953.
      View in: PubMed   Mentions:
    11. Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. Nat Genet. 2017 Dec; 49(12):1693-1704. Blakely CM, Watkins TBK, Wu W, Gini B, Chabon JJ, McCoach CE, McGranahan N, Wilson GA, Birkbak NJ, Olivas VR, Rotow J, Maynard A, Wang V, Gubens MA, Banks KC, Lanman RB, Caulin AF, St John J, Cordero AR, Giannikopoulos P, Simmons AD, Mack PC, Gandara DR, Husain H, Doebele RC, Riess JW, Diehn M, Swanton C, Bivona TG. PMID: 29106415.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    12. Desmoplastic Small Round Blue Cell Tumor: A Review of Treatment and Potential Therapeutic Genomic Alterations. Sarcoma. 2017; 2017:1278268. Bulbul A, Fahy BN, Xiu J, Rashad S, Mustafa A, Husain H, Hayes-Jordan A. PMID: 29225486.
      View in: PubMed   Mentions:
    13. Cancer DNA in the Circulation: The Liquid Biopsy. JAMA. 2017 10 03; 318(13):1272-1274. Husain H, Velculescu VE. PMID: 28973237.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    14. Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy. Oncotarget. 2017 Oct 27; 8(52):89848-89866. Hovelson DH, Liu CJ, Wang Y, Kang Q, Henderson J, Gursky A, Brockman S, Ramnath N, Krauss JC, Talpaz M, Kandarpa M, Chugh R, Tuck M, Herman K, Grasso CS, Quist MJ, Feng FY, Haakenson C, Langmore J, Kamberov E, Tesmer T, Husain H, Lonigro RJ, Robinson D, Smith DC, Alva AS, Hussain MH, Chinnaiyan AM, Tewari M, Mills RE, Morgan TM, Tomlins SA. PMID: 29163793.
      View in: PubMed   Mentions: 3     Fields:    
    15. Direct detection of early-stage cancers using circulating tumor DNA. Sci Transl Med. 2017 Aug 16; 9(403). Phallen J, Sausen M, Adleff V, Leal A, Hruban C, White J, Anagnostou V, Fiksel J, Cristiano S, Papp E, Speir S, Reinert T, Orntoft MW, Woodward BD, Murphy D, Parpart-Li S, Riley D, Nesselbush M, Sengamalay N, Georgiadis A, Li QK, Madsen MR, Mortensen FV, Huiskens J, Punt C, van Grieken N, Fijneman R, Meijer G, Husain H, Scharpf RB, Diaz LA, Jones S, Angiuoli S, Ørntoft T, Nielsen HJ, Andersen CL, Velculescu VE. PMID: 28814544.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    16. Circulating Tumor DNA for Mutation Detection and Identification of Mechanisms of Resistance in Non-Small Cell Lung Cancer. Mol Diagn Ther. 2017 08; 21(4):375-384. Yeung KT, More S, Woodward B, Velculescu V, Husain H. PMID: 28337711.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Utility of Genomic Assessment of Blood-Derived Circulating Tumor DNA (ctDNA) in Patients with Advanced Lung Adenocarcinoma. Clin Cancer Res. 2017 Sep 01; 23(17):5101-5111. Schwaederlé MC, Patel SP, Husain H, Ikeda M, Lanman RB, Banks KC, Talasaz A, Bazhenova L, Kurzrock R. PMID: 28539465.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    18. Cell-Free DNA from Ascites and Pleural Effusions: Molecular Insights into Genomic Aberrations and Disease Biology. Mol Cancer Ther. 2017 05; 16(5):948-955. Husain H, Nykin D, Bui N, Quan D, Gomez G, Woodward B, Venkatapathy S, Duttagupta R, Fung E, Lippman SM, Kurzrock R. PMID: 28468865.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. Monitoring Daily Dynamics of Early Tumor Response to Targeted Therapy by Detecting Circulating Tumor DNA in Urine. Clin Cancer Res. 2017 Aug 15; 23(16):4716-4723. Husain H, Melnikova VO, Kosco K, Woodward B, More S, Pingle SC, Weihe E, Park BH, Tewari M, Erlander MG, Cohen E, Lippman SM, Kurzrock R. PMID: 28420725.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    20. New Targets in Non-Small Cell Lung Cancer. Hematol Oncol Clin North Am. 2017 02; 31(1):113-129. Park SJ, More S, Murtuza A, Woodward BD, Husain H. PMID: 27912827.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    21. Strategies to Overcome Bypass Mechanisms Mediating Clinical Resistance to EGFR Tyrosine Kinase Inhibition in Lung Cancer. Mol Cancer Ther. 2017 02; 16(2):265-272. Husain H, Scur M, Murtuza A, Bui N, Woodward B, Kurzrock R. PMID: 28159915.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    22. Use of Liquid Biopsies in Clinical Oncology: Pilot Experience in 168 Patients. Clin Cancer Res. 2016 Nov 15; 22(22):5497-5505. Schwaederle M, Husain H, Fanta PT, Piccioni DE, Kesari S, Schwab RB, Patel SP, Harismendy O, Ikeda M, Parker BA, Kurzrock R. PMID: 27185373.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCTClinical Trials
    23. Novel Treatment Strategies for Brain Metastases in Non-small-cell Lung Cancer. Curr Treat Options Oncol. 2016 May; 17(5):25. Bui N, Woodward B, Johnson A, Husain H. PMID: 27085533.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    24. Detection rate of actionable mutations in diverse cancers using a biopsy-free (blood) circulating tumor cell DNA assay. Oncotarget. 2016 Mar 01; 7(9):9707-17. Schwaederle M, Husain H, Fanta PT, Piccioni DE, Kesari S, Schwab RB, Banks KC, Lanman RB, Talasaz A, Parker BA, Kurzrock R. PMID: 26848768.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    25. An integrin ß3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol. 2014 May; 16(5):457-68. Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, Elliott KC, Yebra M, Mielgo A, Lowy AM, Husain H, Cascone T, Diao L, Wang J, Wistuba II, Heymach JV, Lippman SM, Desgrosellier JS, Anand S, Weis SM, Cheresh DA. PMID: 24747441.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    26. Nuclear epidermal growth factor receptor and p16 expression in head and neck squamous cell carcinoma. Laryngoscope. 2012 Dec; 122(12):2762-8. Husain H, Psyrri A, Markovic A, Rampias T, Pectasides E, Wang H, Slebos R, Yarbrough WG, Burtness B, Chung CH. PMID: 23086695.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    27. Pre- and post-operative plasma glial fibrillary acidic protein levels in patients with newly diagnosed gliomas. J Neurooncol. 2012 Aug; 109(1):123-7. Husain H, Savage W, Grossman SA, Ye X, Burger PC, Everett A, Bettegowda C, Diaz LA, Blair C, Romans KE, Holdhoff M. PMID: 22492246.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    28. ALK-targeted therapy for lung cancer: ready for prime time. Oncology (Williston Park). 2011 Jun; 25(7):597-601. Husain H, Rudin CM. PMID: 21888258.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    29. Radiotherapy in small-cell lung cancer. Oncology (Williston Park). 2010 Oct; 24(11):1047, 1049. Husain H, Hann C, Hales R. PMID: 21155457.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Polymorphisms in interleukin 1 beta and interleukin 1 receptor antagonist associated with tumor recurrence in stage II colon cancer. Pharmacogenet Genomics. 2009 Feb; 19(2):95-102. Lurje G, Hendifar AE, Schultheis AM, Pohl A, Husain H, Yang D, Manegold PC, Ning Y, Zhang W, Lenz HJ. PMID: 18987561.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    31. Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab. Clin Cancer Res. 2008 Dec 01; 14(23):7884-95. Lurje G, Nagashima F, Zhang W, Yang D, Chang HM, Gordon MA, El-Khoueiry A, Husain H, Wilson PM, Ladner RD, Mauro DJ, Langer C, Rowinsky EK, Lenz HJ. PMID: 19047118.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    32. Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer. Pharmacogenet Genomics. 2008 Feb; 18(2):161-8. Lurje G, Zhang W, Yang D, Groshen S, Hendifar AE, Husain H, Nagashima F, Chang HM, Fazzone W, Ladner RD, Pohl A, Ning Y, Iqbal S, El-Khoueiry A, Lenz HJ. PMID: 18192902.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
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