Jair Lage De Siqueira Neto

Title(s)Associate Adjunct Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-9574-8174 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Institut Pasteur KoreaPost-doctorate2009
    Unicamp, SP - BrazilPh.D. Genetics and Molecular Biology2007Dept. Genetics, Microbiology & Immunology
    Unicamp, SP - BrazilBS Biology2003Institute of Biology

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining. NPJ Drug Discov. 2025; 2(1):3. Godinez-Macias KP, Chen D, Wallis JL, Siegel MG, Adam A, Bopp S, Carolino K, Coulson LB, Durst G, Thathy V, Esherick L, Farringer MA, Flannery EL, Forte B, Liu T, Godoy Magalhaes L, Gupta AK, Istvan ES, Jiang T, Kumpornsin K, Lobb K, McLean KJ, Moura IMR, Okombo J, Payne NC, Plater A, Rao SPS, Siqueira-Neto JL, Somsen BA, Summers RL, Zhang R, Gilson MK, Gamo FJ, Campo B, Baragaña B, Duffy J, Gilbert IH, Lukens AK, Dechering KJ, Niles JC, McNamara CW, Cheng X, Birkholtz LM, Bronkhorst AW, Fidock DA, Wirth DF, Goldberg DE, Lee MCS, Winzeler EA. PMID: 40066064; PMCID: PMC11892419.
      View in: PubMed   Mentions:
    2. Identification of Substituted 4-Aminocinnolines as Broad-Spectrum Antiparasitic Agents. ACS Infect Dis. 2025 Feb 12. Spaulding A, Sharma A, Giardini MA, Hoffman B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Millard CC, Devine WG, Singh B, Silva EM, Leed SE, Roncal NE, Penn EC, Erath J, Kumar G, Sepulveda Y, Garcia A, Rodriguez A, El-Sakkary N, Sciotti RJ, Campbell RF, Momper JD, McKerrow JH, Caffrey CR, Siqueira-Neto JL, Pollastri MP, Mensa-Wilmot K, Ferrins L. PMID: 39936822.
      View in: PubMed   Mentions:    Fields:    
    3. Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance. Science. 2024 Nov 29; 386(6725):eadk9893. Luth MR, Godinez-Macias KP, Chen D, Okombo J, Thathy V, Cheng X, Daggupati S, Davies H, Dhingra SK, Economy JM, Edgar RCS, Gomez-Lorenzo MG, Istvan ES, Jado JC, LaMonte GM, Melillo B, Mok S, Narwal SK, Ndiaye T, Ottilie S, Palomo Diaz S, Park H, Peña S, Rocamora F, Sakata-Kato T, Small-Saunders JL, Summers RL, Tumwebaze PK, Vanaerschot M, Xia G, Yeo T, You A, Gamo FJ, Goldberg DE, Lee MCS, McNamara CW, Ndiaye D, Rosenthal PJ, Schreiber SL, Serra G, De Siqueira-Neto JL, Skinner-Adams TS, Uhlemann AC, Kato N, Lukens AK, Wirth DF, Fidock DA, Winzeler EA. PMID: 39607932; PMCID: PMC11809290.
      View in: PubMed   Mentions:    Fields:    
    4. Nanomolar activity of coumarin-3-thiosemicarbazones targeting Trypanosoma cruzi cruzain and the T. brucei cathepsin L-like protease. Eur J Med Chem. 2025 Feb 05; 283:117109. Nunes JA, Santos-Júnior PFDS, Gomes MC, Ferreira LAS, Padilha EKA, Teixeira TR, Stanger EJ, Kaur Y, Silva EBD, Costa CACB, Freitas JD, Araújo-Júnior JX, Mendonça-Junior FJB, Giardini MA, Siqueira-Neto JL, Caffrey CR, Zhan P, Cardoso SH, Silva-Júnior EFD. PMID: 39653622.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining. Res Sq. 2024 Nov 26. Godinez-Macias KP, Chen D, Wallis JL, Siegel MG, Adam A, Bopp S, Carolino K, Coulson LB, Durst G, Thathy V, Esherick L, Farringer MA, Flannery EL, Forte B, Liu T, Magalhaes LG, Gupta AK, Istvan ES, Jiang T, Kumpornsin K, Lobb K, McLean K, Moura IMR, Okombo J, Payne NC, Plater A, Rao SPS, Siqueira-Neto JL, Somsen BA, Summers RL, Zhang R, Gilson MK, Gamo FJ, Campo B, Baragaña B, Duffy J, Gilbert IH, Lukens AK, Dechering KJ, Niles JC, McNamara CW, Cheng X, Birkholtz LM, Bronkhorst AW, Fidock DA, Wirth DF, Goldberg DE, Lee MCS, Winzeler EA. PMID: 39649165; PMCID: PMC11623766.
      View in: PubMed   Mentions:
    6. Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (S, Se) and Their Azole Derivatives against Chagas Disease. J Med Chem. 2024 Nov 14; 67(21):19038-19056. Rubio-Hernández M, Alcolea V, Barbosa da Silva E, Giardini MA, M Fernandes TH, Martínez-Sáez N, O'Donoghue AJ, Siqueira-Neto JL, Pérez-Silanes S. PMID: 39485736.
      View in: PubMed   Mentions:    Fields:    
    7. Author Correction: Antimalarial drug discovery: progress and approaches. Nat Rev Drug Discov. 2024 Nov; 23(11):880. Siqueira-Neto JL, Wicht KJ, Chibale K, Burrows JN, Fidock DA, Winzeler EA. PMID: 39271962.
      View in: PubMed   Mentions:    Fields:    
    8. Oral Pyronaridine Tetraphosphate Reduces Tissue Presence of Parasites in a Mouse Model of Chagas Disease. ACS Omega. 2024 Sep 03; 9(35):37288-37298. Siqueira-Neto JL, Lane TR, Bernatchez JA, Calvet Alvarez CM, Barbosa da Silva E, Giardini MA, Ekins S. PMID: 39246496; PMCID: PMC11375811.
      View in: PubMed   Mentions:
    9. Pirfenidone Prevents Heart Fibrosis during Chronic Chagas Disease Cardiomyopathy. Int J Mol Sci. 2024 Jul 03; 25(13). Silva TA, Thomas D, Siqueira-Neto JL, Calvet CM. PMID: 39000409; PMCID: PMC11242150.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun. 2024 Jan 31; 15(1):937. Xie SC, Wang Y, Morton CJ, Metcalfe RD, Dogovski C, Pasaje CFA, Dunn E, Luth MR, Kumpornsin K, Istvan ES, Park JS, Fairhurst KJ, Ketprasit N, Yeo T, Yildirim O, Bhebhe MN, Klug DM, Rutledge PJ, Godoy LC, Dey S, De Souza ML, Siqueira-Neto JL, Du Y, Puhalovich T, Amini M, Shami G, Loesbanluechai D, Nie S, Williamson N, Jana GP, Maity BC, Thomson P, Foley T, Tan DS, Niles JC, Han BW, Goldberg DE, Burrows J, Fidock DA, Lee MCS, Winzeler EA, Griffin MDW, Todd MH, Tilley L. PMID: 38297033; PMCID: PMC10831071.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    11. Antimalarial drug discovery: progress and approaches. Nat Rev Drug Discov. 2023 10; 22(10):807-826. Siqueira-Neto JL, Wicht KJ, Chibale K, Burrows JN, Fidock DA, Winzeler EA. PMID: 37652975; PMCID: PMC10543600.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    12. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Res Sq. 2023 Jul 27. Xie SC, Wang Y, Morton CJ, Metcalfe RD, Dogovski C, Pasaje CFA, Dunn E, Luth MR, Kumpornsin K, Istvan ES, Park JS, Fairhurst KJ, Ketprasit N, Yeo T, Yildirim O, Bhebhe MN, Klug DM, Rutledge PJ, Godoy LC, Dey S, De Souza ML, Siqueira-Neto JL, Du Y, Puhalovich T, Amini M, Shami G, Loesbanluechai D, Nie S, Williamson N, Jana GP, Maity BC, Thomson P, Foley T, Tan DS, Niles JC, Han BW, Goldberg DE, Burrows J, Fidock DA, Lee MCS, Winzeler EA, Griffin MDW, Todd MH, Tilley L. PMID: 37546892; PMCID: PMC10402266.
      View in: PubMed   Mentions:
    13. Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors. Future Med Chem. 2023 06; 15(11):959-985. Maltarollo VG, da Silva EB, Kronenberger T, Sena Andrade MM, de Lima Marques GV, Cândido Oliveira NJ, Santos LH, Oliveira Rezende Júnior C, Cassiano Martinho AC, Skinner D, Fajtová P, M Fernandes TH, Silveira Dos Santos ED, Rodrigues Gazolla PA, Martins de Souza AP, da Silva ML, Dos Santos FS, Lavorato SN, Oliveira Bretas AC, Carvalho DT, Franco LL, Luedtke S, Giardini MA, Poso A, Dias LC, Podust LM, Alves RJ, McKerrow J, Andrade SF, Teixeira RR, Siqueira-Neto JL, O'Donoghue A, de Oliveira RB, Ferreira RS. PMID: 37435731.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of Leishmania infection. Front Trop Dis. 2023; 3. Kavouris JA, McCall LI, Giardini MA, De Muylder G, Thomas D, Garcia-Pérez A, Cantizani J, Cotillo I, Fiandor JM, McKerrow JH, De Oliveira CI, Siqueira-Neto JL, González S, Brown LE, Schaus SE. PMID: 36818551; PMCID: PMC9937549.
      View in: PubMed   Mentions: 1  
    15. Enantioselective inhibition of the SARS-CoV-2 main protease with rhenium(i) picolinic acid complexes. Chem Sci. 2023 Jan 18; 14(3):711-720. Karges J, Giardini MA, Blacque O, Woodworth B, Siqueira-Neto JL, Cohen SM. PMID: 36741526; PMCID: PMC9848156.
      View in: PubMed   Mentions: 8  
    16. A Broad Spectrum Antiparasitic Activity of Organotin (IV) Derivatives and Its Untargeted Proteomic Profiling Using Leishmania donovani. Pathogens. 2022 Nov 26; 11(12). Hayat O, Ullah N, Sirajuddin M, Giardini MA, Nguyen JV, Francisco KR, Liu LJ, Sun YU, Maurya S, McGrosso D, Gonzalez DJ, Caffrey CR, Debnath A, Siqueira-Neto JL. PMID: 36558759; PMCID: PMC9785441.
      View in: PubMed   Mentions:
    17. From rational design to serendipity: Discovery of novel thiosemicarbazones as potent trypanocidal compounds. Eur J Med Chem. 2022 Dec 15; 244:114876. Braga SFP, Santos VC, Vieira RP, Silva EBD, Monti L, Krake SH, Martinez PDG, Dias LC, Caffrey CR, Siqueira-Neto JL, de Oliveira RB, Ferreira RS. PMID: 36343429.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    18. Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika. J Chem Inf Model. 2022 12 26; 62(24):6825-6843. Mottin M, de Paula Sousa BK, de Moraes Roso Mesquita NC, de Oliveira KIZ, Noske GD, Sartori GR, de Oliveira Albuquerque A, Urbina F, Puhl AC, Moreira-Filho JT, Souza GE, Guido RVC, Muratov E, Neves BJ, Martins da Silva JH, Clark AE, Siqueira-Neto JL, Perryman AL, Oliva G, Ekins S, Andrade CH. PMID: 36239304; PMCID: PMC9923514.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV-2. J Chem Inf Model. 2022 12 26; 62(24):6553-6573. Santos LH, Kronenberger T, Almeida RG, Silva EB, Rocha REO, Oliveira JC, Barreto LV, Skinner D, Fajtová P, Giardini MA, Woodworth B, Bardine C, Lourenço AL, Craik CS, Poso A, Podust LM, McKerrow JH, Siqueira-Neto JL, O'Donoghue AJ, da Silva Júnior EN, Ferreira RS. PMID: 35960688.
      View in: PubMed   Mentions: 16     Fields:    
    20. Identification of Leucinostatins from Ophiocordyceps sp. as Antiparasitic Agents against Trypanosoma cruzi. ACS Omega. 2022 Mar 08; 7(9):7675-7682. Bernatchez JA, Kil YS, Barbosa da Silva E, Thomas D, McCall LI, Wendt KL, Souza JM, Ackermann J, McKerrow JH, Cichewicz RH, Siqueira-Neto JL. PMID: 35284725; PMCID: PMC8908367.
      View in: PubMed   Mentions: 2  
    21. Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2. bioRxiv. 2022 Jan 05. Santos LH, Kronenberger T, Almeida RG, Silva EB, Rocha REO, Oliveira JC, Barreto LV, Skinner D, Fajtová P, Giardini MA, Woodworth B, Bardine C, Lourenço AL, Craik CS, Poso A, Podust LM, McKerrow JH, Siqueira-Neto JL, O'Donoghue AJ, da Silva Júnior EN, Ferreira RS. PMID: 35018373; PMCID: PMC8750648.
      View in: PubMed   Mentions:
    22. Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma. Cancer Res. 2022 02 01; 82(3):377-390. Sen A, Prager BC, Zhong C, Park D, Zhu Z, Gimple RC, Wu Q, Bernatchez JA, Beck S, Clark AE, Siqueira-Neto JL, Rich JN, McVicker G. PMID: 34903607; PMCID: PMC9122831.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells. Cancer Discov. 2022 02; 12(2):502-521. Qiu Z, Zhao L, Shen JZ, Liang Z, Wu Q, Yang K, Min L, Gimple RC, Yang Q, Bhargava S, Jin C, Kim C, Hinz D, Dixit D, Bernatchez JA, Prager BC, Zhang G, Dong Z, Lv D, Wang X, Kim LJY, Zhu Z, Jones KA, Zheng Y, Wang X, Siqueira-Neto JL, Chavez L, Fu XD, Spruck C, Rich JN. PMID: 34615656; PMCID: PMC8831451.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    24. Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas Disease. PLoS Negl Trop Dis. 2021 10; 15(10):e0009819. Dean DA, Gautham G, Siqueira-Neto JL, McKerrow JH, Dorrestein PC, McCall LI. PMID: 34606502; PMCID: PMC8516257.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    25. Structure-Based Optimization of Quinazolines as Cruzain and TbrCATL Inhibitors. J Med Chem. 2021 09 09; 64(17):13054-13071. Barbosa da Silva E, Rocha DA, Fortes IS, Yang W, Monti L, Siqueira-Neto JL, Caffrey CR, McKerrow J, Andrade SF, Ferreira RS. PMID: 34461718.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    26. Machine Learning Models Identify Inhibitors of SARS-CoV-2. J Chem Inf Model. 2021 Sep 27; 61(9):4224-4235. Gawriljuk VO, Zin PPK, Puhl AC, Zorn KM, Foil DH, Lane TR, Hurst B, Tavella TA, Costa FTM, Lakshmanane P, Bernatchez J, Godoy AS, Oliva G, Siqueira-Neto JL, Madrid PB, Ekins S. PMID: 34387990; PMCID: PMC8574161.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    27. Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases. J Med Chem. 2021 08 12; 64(15):11267-11287. Li L, Chenna BC, Yang KS, Cole TR, Goodall ZT, Giardini M, Moghadamchargari Z, Hernandez EA, Gomez J, Calvet CM, Bernatchez JA, Mellott DM, Zhu J, Rademacher A, Thomas D, Blankenship LR, Drelich A, Laganowsky A, Tseng CK, Liu WR, Wand AJ, Cruz-Reyes J, Siqueira-Neto JL, Meek TD. PMID: 34288674; PMCID: PMC10504874.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    28. In vitro anti-Trypanosoma cruzi activity enhancement of curcumin by its monoketone tetramethoxy analog diveratralacetone. Curr Res Parasitol Vector Borne Dis. 2021; 1:100031. Souza JM, Vieira TM, Candido ACBB, Tezuka DY, Rao GS, de Albuquerque S, Crotti AEM, Siqueira-Neto JL, Magalhães LG. PMID: 35284878; PMCID: PMC8906099.
      View in: PubMed   Mentions: 2  
    29. Dysregulation of Glycerophosphocholines in the Cutaneous Lesion Caused by Leishmania major in Experimental Murine Models. Pathogens. 2021 May 13; 10(5). Parab AR, Thomas D, Lostracco-Johnson S, Siqueira-Neto JL, McKerrow JH, Dorrestein PC, McCall LI. PMID: 34068119; PMCID: PMC8152770.
      View in: PubMed   Mentions: 5  
    30. A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells. ACS Chem Biol. 2021 04 16; 16(4):642-650. Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Kocurek KI, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Yoon MC, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Hook V, Frueh F, Hurst BL, Wang H, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH. PMID: 33787221.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    31. A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells. bioRxiv. 2020 Oct 30. Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Frueh F, Hurst BL, Wang H, Kocurek KI, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH. PMID: 33140046; PMCID: PMC7605553.
      View in: PubMed   Mentions: 1  
    32. Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi. PLoS Negl Trop Dis. 2020 10; 14(10):e0008728. Shiratsubaki IS, Fang X, Souza ROO, Palsson BO, Silber AM, Siqueira-Neto JL. PMID: 33021977; PMCID: PMC7567352.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    33. Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole. PLoS Negl Trop Dis. 2020 09; 14(9):e0008726. Calvet CM, Silva TA, Thomas D, Suzuki B, Hirata K, Siqueira-Neto JL, McKerrow JH. PMID: 32970692; PMCID: PMC7561097.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    34. The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies. Cancer Discov. 2020 11; 10(11):1722-1741. Prager BC, Vasudevan HN, Dixit D, Bernatchez JA, Wu Q, Wallace LC, Bhargava S, Lee D, King BH, Morton AR, Gimple RC, Pekmezci M, Zhu Z, Siqueira-Neto JL, Wang X, Xie Q, Chen C, Barnett GH, Vogelbaum MA, Mack SC, Chavez L, Perry A, Raleigh DR, Rich JN. PMID: 32703768; PMCID: PMC8194360.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    35. Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways. PLoS Negl Trop Dis. 2020 05; 14(5):e0007980. Wozniak JM, Silva TA, Thomas D, Siqueira-Neto JL, McKerrow JH, Gonzalez DJ, Calvet CM. PMID: 32433643; PMCID: PMC7279607.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    36. Palstimolide A: A Complex Polyhydroxy Macrolide with Antiparasitic Activity. Molecules. 2020 Mar 31; 25(7). Keller L, Siqueira-Neto JL, Souza JM, Eribez K, LaMonte GM, Smith JE, Gerwick WH. PMID: 32244512; PMCID: PMC7180531.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    37. High-Throughput Screening of the ReFRAME Library Identifies Potential Drug Repurposing Candidates for Trypanosoma cruzi. Microorganisms. 2020 Mar 26; 8(4). Bernatchez JA, Chen E, Hull MV, McNamara CW, McKerrow JH, Siqueira-Neto JL. PMID: 32224991; PMCID: PMC7232187.
      View in: PubMed   Mentions: 9  
    38. Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity. J Med Chem. 2020 03 26; 63(6):3298-3316. Chenna BC, Li L, Mellott DM, Zhai X, Siqueira-Neto JL, Calvet Alvarez C, Bernatchez JA, Desormeaux E, Alvarez Hernandez E, Gomez J, McKerrow JH, Cruz-Reyes J, Meek TD. PMID: 32125159; PMCID: PMC7261474.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    39. Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis. Cell Stem Cell. 2020 02 06; 26(2):187-204.e10. Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. PMID: 31956038; PMCID: PMC9628766.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    40. Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors. ACS Med Chem Lett. 2020 Mar 12; 11(3):249-257. Singh B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Silva EM, Bachovchin KA, Klug DM, Jalani HB, Bag S, Buskes MJ, Leed SE, Roncal NE, Penn EC, Erath J, Rodriguez A, Sciotti RJ, Campbell RF, McKerrow J, Siqueira-Neto JL, Ferrins L, Pollastri MP. PMID: 32184953; PMCID: PMC7073875.
      View in: PubMed   Mentions: 14  
    41. Drugs for the Treatment of Zika Virus Infection. J Med Chem. 2020 01 23; 63(2):470-489. Bernatchez JA, Tran LT, Li J, Luan Y, Siqueira-Neto JL, Li R. PMID: 31549836.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    42. Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain. J Med Chem. 2019 10 24; 62(20):9026-9044. Boudreau PD, Miller BW, McCall LI, Almaliti J, Reher R, Hirata K, Le T, Siqueira-Neto JL, Hook V, Gerwick WH. PMID: 31539239; PMCID: PMC7240701.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    43. Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells. Viruses. 2019 04 20; 11(4). Bernatchez JA, Coste M, Beck S, Wells GA, Luna LA, Clark AE, Zhu Z, Hecht D, Rich JN, Sohl CD, Purse BW, Siqueira-Neto JL. PMID: 31010044; PMCID: PMC6521205.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    44. Mechanism of Action of Methotrexate Against Zika Virus. Viruses. 2019 04 10; 11(4). Beck S, Zhu Z, Oliveira MF, Smith DM, Rich JN, Bernatchez JA, Siqueira-Neto JL. PMID: 30974762; PMCID: PMC6521145.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    45. Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma. J Exp Med. 2019 05 06; 216(5):1071-1090. Mack SC, Singh I, Wang X, Hirsch R, Wu Q, Villagomez R, Bernatchez JA, Zhu Z, Gimple RC, Kim LJY, Morton A, Lai S, Qiu Z, Prager BC, Bertrand KC, Mah C, Zhou W, Lee C, Barnett GH, Vogelbaum MA, Sloan AE, Chavez L, Bao S, Scacheri PC, Siqueira-Neto JL, Lin CY, Rich JN. PMID: 30948495; PMCID: PMC6504206.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    46. High Throughput and Computational Repurposing for Neglected Diseases. Pharm Res. 2018 Dec 17; 36(2):27. Hernandez HW, Soeung M, Zorn KM, Ashoura N, Mottin M, Andrade CH, Caffrey CR, de Siqueira-Neto JL, Ekins S. PMID: 30560386; PMCID: PMC6792295.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    47. Development and Validation of a Phenotypic High-Content Imaging Assay for Assessing the Antiviral Activity of Small-Molecule Inhibitors Targeting Zika Virus. Antimicrob Agents Chemother. 2018 10; 62(10). Bernatchez JA, Yang Z, Coste M, Li J, Beck S, Liu Y, Clark AE, Zhu Z, Luna LA, Sohl CD, Purse BW, Li R, Siqueira-Neto JL. PMID: 30061280; PMCID: PMC6153842.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    48. Cysteine proteases in protozoan parasites. PLoS Negl Trop Dis. 2018 08; 12(8):e0006512. Siqueira-Neto JL, Debnath A, McCall LI, Bernatchez JA, Ndao M, Reed SL, Rosenthal PJ. PMID: 30138453; PMCID: PMC6107107.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    49. Author Correction: Blocking Zika virus vertical transmission. Sci Rep. 2018 Jun 05; 8(1):8794. Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR. PMID: 29867187; PMCID: PMC5986756.
      View in: PubMed   Mentions: 3     Fields:    
    50. Identification of Anti-Trypanosoma cruzi Lead Compounds with Putative Immunomodulatory Activity. Antimicrob Agents Chemother. 2018 Apr; 62(4). Otta DA, de Araújo FF, de Rezende VB, Souza-Fagundes EM, Elói-Santos SM, Costa-Silva MF, Santos RA, Costa HA, Siqueira-Neto JL, Martins-Filho OA, Teixeira-Carvalho A. PMID: 29437629; PMCID: PMC5913944.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    51. Experimental Chagas disease-induced perturbations of the fecal microbiome and metabolome. PLoS Negl Trop Dis. 2018 03; 12(3):e0006344. McCall LI, Tripathi A, Vargas F, Knight R, Dorrestein PC, Siqueira-Neto JL. PMID: 29529084; PMCID: PMC5864088.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    52. Blocking Zika virus vertical transmission. Sci Rep. 2018 01 19; 8(1):1218. Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR. PMID: 29352135; PMCID: PMC5775359.
      View in: PubMed   Mentions: 25     Fields:    
    53. [Not Available]. Rev Soc Bras Med Trop. 2018; 51(2):123-124. Siqueira-Neto JL. PMID: 29768542.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    54. 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2017 12; 11(12):e0006132. Calvet CM, Choi JY, Thomas D, Suzuki B, Hirata K, Lostracco-Johnson S, de Mesquita LB, Nogueira A, Meuser-Batista M, Silva TA, Siqueira-Neto JL, Roush WR, de Souza Pereira MC, McKerrow JH, Podust LM. PMID: 29281643; PMCID: PMC5744913.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    55. Mass Spectrometry-Based Chemical Cartography of a Cardiac Parasitic Infection. Anal Chem. 2017 10 03; 89(19):10414-10421. McCall LI, Morton JT, Bernatchez JA, de Siqueira-Neto JL, Knight R, Dorrestein PC, McKerrow JH. PMID: 28892370; PMCID: PMC6298790.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    56. Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast. ACS Chem Biol. 2017 02 17; 12(2):422-434. Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, Amaro RE, Podust LM, Durrant JD, Winzeler EA. PMID: 27977118; PMCID: PMC5649375.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    57. Design, synthesis, molecular docking and biological evaluation of thiophen-2-iminothiazolidine derivatives for use against Trypanosoma cruzi. Bioorg Med Chem. 2016 Sep 15; 24(18):4228-4240. Silva-Júnior EF, Silva EPS, França PHB, Silva JPN, Barreto EO, Silva EB, Ferreira RS, Gatto CC, Moreira DRM, Siqueira-Neto JL, Mendonça-Júnior FJB, Lima MCA, Bortoluzzi JH, Scotti MT, Scotti L, Meneghetti MR, Aquino TM, Araújo-Júnior JX. PMID: 27475533.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    58. Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis. PLoS Pathog. 2016 05; 12(5):e1005519. McCall LI, Siqueira-Neto JL, McKerrow JH. PMID: 27227827; PMCID: PMC4881934.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    59. Shedding Light on Synergistic Chemical Genetic Connections with Machine Learning. Cell Syst. 2015 Dec 23; 1(6):377-9. Ekins S, Siqueira-Neto JL. PMID: 27136350.
      View in: PubMed   Mentions: 2     Fields:    
    60. Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. ACS Med Chem Lett. 2016 Jan 14; 7(1):77-82. Jones BD, Tochowicz A, Tang Y, Cameron MD, McCall LI, Hirata K, Siqueira-Neto JL, Reed SL, McKerrow JH, Roush WR. PMID: 26819670; PMCID: PMC4716606.
      View in: PubMed   Mentions: 7  
    61. Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. ACS Chem Biol. 2015 Oct 16; 10(10):2373-81. Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach MA, Linington RG. PMID: 26270237; PMCID: PMC7505085.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    62. Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. PLoS Negl Trop Dis. 2015; 9(6):e0003878. Ekins S, de Siqueira-Neto JL, McCall LI, Sarker M, Yadav M, Ponder EL, Kallel EA, Kellar D, Chen S, Arkin M, Bunin BA, McKerrow JH, Talcott C. PMID: 26114876; PMCID: PMC4482694.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    63. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003588. McCall LI, El Aroussi A, Choi JY, Vieira DF, De Muylder G, Johnston JB, Chen S, Kellar D, Siqueira-Neto JL, Roush WR, Podust LM, McKerrow JH. PMID: 25768284; PMCID: PMC4359151.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    64. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrob Agents Chemother. 2015 May; 59(5):2666-77. Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, de Oliveira RB, Ferreira RS. PMID: 25712353; PMCID: PMC4394791.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    65. Proteomic-based approach to gain insight into reprogramming of THP-1 cells exposed to Leishmania donovani over an early temporal window. Infect Immun. 2015 May; 83(5):1853-68. Singh AK, Pandey RK, Siqueira-Neto JL, Kwon YJ, Freitas-Junior LH, Shaha C, Madhubala R. PMID: 25690103; PMCID: PMC4399049.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    66. Synthesis and Evaluation of DNA Based Quantum Dot Fluorescence In Situ Hybridization (FISH) Probe for Telomere Detection. J Nanosci Nanotechnol. 2015 Feb; 15(2):1708-13. Choi Y, De Siqueira Neto JL, Moraes C, Freitas L, Song R. PMID: 26353719.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    67. Current and Future Chemotherapy for Chagas Disease. Curr Med Chem. 2015; 22(37):4293-312. Gaspar L, Moraes CB, Freitas-Junior LH, Ferrari S, Costantino L, Costi MP, Coron RP, Smith TK, Siqueira-Neto JL, McKerrow JH, Cordeiro-da-Silva A. PMID: 26477622.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    68. Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51. J Med Chem. 2014 Dec 11; 57(23):10162-75. Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM. PMID: 25393646; PMCID: PMC4266343.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    69. RPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain. FEBS Lett. 2014 Dec 20; 588(24):4740-8. Pavani RS, Fernandes C, Perez AM, Vasconcelos EJ, Siqueira-Neto JL, Fontes MR, Cano MI. PMID: 25451229.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    70. Drug discovery for human African trypanosomiasis: identification of novel scaffolds by the newly developed HTS SYBR Green assay for Trypanosoma brucei. J Biomol Screen. 2015 Jan; 20(1):70-81. Faria J, Moraes CB, Song R, Pascoalino BS, Lee N, Siqueira-Neto JL, Cruz DJ, Parkinson T, Ioset JR, Cordeiro-da-Silva A, Freitas-Junior LH. PMID: 25342146.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    71. Lead identification to clinical candidate selection: drugs for Chagas disease. J Biomol Screen. 2015 Jan; 20(1):101-11. Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. PMID: 25281737.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    72. 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency. J Med Chem. 2014 Aug 28; 57(16):6989-7005. Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM. PMID: 25101801; PMCID: PMC4148169.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    73. Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a]benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi. Eur J Med Chem. 2014 Sep 12; 84:395-403. Oh S, Kim S, Kong S, Yang G, Lee N, Han D, Goo J, Siqueira-Neto JL, Freitas-Junior LH, Song R. PMID: 25036797.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    74. An image-based algorithm for precise and accurate high throughput assessment of drug activity against the human parasite Trypanosoma cruzi. PLoS One. 2014; 9(2):e87188. Moon S, Siqueira-Neto JL, Moraes CB, Yang G, Kang M, Freitas-Junior LH, Hansen MA. PMID: 24503652; PMCID: PMC3913590.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    75. Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease. ACS Med Chem Lett. 2014 Feb 13; 5(2):149-53. Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, Rodriguez A, Palmer MA, Foley M, Schreiber SL, Munoz B. PMID: 24900788; PMCID: PMC4027639.
      View in: PubMed   Mentions: 13  
    76. An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages. PLoS Negl Trop Dis. 2012; 6(6):e1671. Siqueira-Neto JL, Moon S, Jang J, Yang G, Lee C, Moon HK, Chatelain E, Genovesio A, Cechetto J, Freitas-Junior LH. PMID: 22720099; PMCID: PMC3373640.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    77. Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it? Int J Parasitol Drugs Drug Resist. 2012 Dec; 2:11-9. Freitas-Junior LH, Chatelain E, Kim HA, Siqueira-Neto JL. PMID: 24533267; PMCID: PMC3862432.
      View in: PubMed   Mentions: 87     Fields:    
    78. The Leishmania amazonensis TRF (TTAGGG repeat-binding factor) homologue binds and co-localizes with telomeres. BMC Microbiol. 2010 May 07; 10:136. da Silva MS, Perez AM, da Silveira Rde C, de Moraes CE, Siqueira-Neto JL, Freitas Lde H, Cano MI. PMID: 20459667; PMCID: PMC2896790.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    79. Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds. PLoS Negl Trop Dis. 2010 May 04; 4(5):e675. Siqueira-Neto JL, Song OR, Oh H, Sohn JH, Yang G, Nam J, Jang J, Cechetto J, Lee CB, Moon S, Genovesio A, Chatelain E, Christophe T, Freitas-Junior LH. PMID: 20454559; PMCID: PMC2864270.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    80. Automated nuclear analysis of Leishmania major telomeric clusters reveals changes in their organization during the parasite's life cycle. PLoS One. 2008 Jun 11; 3(6):e2313. Dossin Fde M, Dufour A, Dusch E, Siqueira-Neto JL, Moraes CB, Yang GS, Cano MI, Genovesio A, Freitas-Junior LH. PMID: 18545650; PMCID: PMC2396463.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    81. LaTBP1: a Leishmania amazonensis DNA-binding protein that associates in vivo with telomeres and GT-rich DNA using a Myb-like domain. Arch Biochem Biophys. 2007 Sep 15; 465(2):399-409. Lira CB, de Siqueira Neto JL, Khater L, Cagliari TC, Peroni LA, dos Reis JR, Ramos CH, Cano MI. PMID: 17678615.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    82. LaRbp38: a Leishmania amazonensis protein that binds nuclear and kinetoplast DNAs. Biochem Biophys Res Commun. 2007 Jul 06; 358(3):854-60. Lira CB, Siqueira Neto JL, Giardini MA, Winck FV, Ramos CH, Cano MI. PMID: 17506988.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    83. The putative telomerase reverse transcriptase component of Leishmania amazonensis: gene cloning and characterization. Parasitol Res. 2006 Apr; 98(5):447-54. Giardini MA, Lira CB, Conte FF, Camillo LR, de Siqueira Neto JL, Ramos CH, Cano MI. PMID: 16416120.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
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