Jair Lage De Siqueira Neto
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| Title(s) | Associate Adjunct Professor, School of Pharmacy and Pharmaceutical Science |
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| School | Vc-health Sciences-schools |
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| Address | 9500 Gilman Drive #
La Jolla CA 92093
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| vCard | Download vCard |
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Biography
| Institut Pasteur Korea | Post-doctorate | 2009 | |
| Unicamp, SP - Brazil | Ph.D. Genetics and Molecular Biology | 2007 | Dept. Genetics, Microbiology & Immunology |
| Unicamp, SP - Brazil | BS Biology | 2003 | Institute of Biology |
Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. ACS Med Chem Lett. 2016 Jan 14; 7(1):77-82.
Jones BD, Tochowicz A, Tang Y, Cameron MD, McCall LI, Hirata K, Siqueira-Neto JL, Reed SL, McKerrow JH, Roush WR. PMID: 26819670; PMCID: PMC4716606.
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PubMed Mentions:
7
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Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. ACS Chem Biol. 2015 Oct 16; 10(10):2373-81.
Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach MA, Linington RG. PMID: 26270237; PMCID: PMC7505085.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. PLoS Negl Trop Dis. 2015; 9(6):e0003878.
Ekins S, de Siqueira-Neto JL, McCall LI, Sarker M, Yadav M, Ponder EL, Kallel EA, Kellar D, Chen S, Arkin M, Bunin BA, McKerrow JH, Talcott C. PMID: 26114876; PMCID: PMC4482694.
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PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003588.
McCall LI, El Aroussi A, Choi JY, Vieira DF, De Muylder G, Johnston JB, Chen S, Kellar D, Siqueira-Neto JL, Roush WR, Podust LM, McKerrow JH. PMID: 25768284; PMCID: PMC4359151.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrob Agents Chemother. 2015 May; 59(5):2666-77.
Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, de Oliveira RB, Ferreira RS. PMID: 25712353; PMCID: PMC4394791.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Proteomic-based approach to gain insight into reprogramming of THP-1 cells exposed to Leishmania donovani over an early temporal window. Infect Immun. 2015 May; 83(5):1853-68.
Singh AK, Pandey RK, Siqueira-Neto JL, Kwon YJ, Freitas-Junior LH, Shaha C, Madhubala R. PMID: 25690103; PMCID: PMC4399049.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Synthesis and Evaluation of DNA Based Quantum Dot Fluorescence In Situ Hybridization (FISH) Probe for Telomere Detection. J Nanosci Nanotechnol. 2015 Feb; 15(2):1708-13.
Choi Y, De Siqueira Neto JL, Moraes C, Freitas L, Song R. PMID: 26353719.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Current and Future Chemotherapy for Chagas Disease. Curr Med Chem. 2015; 22(37):4293-312.
Gaspar L, Moraes CB, Freitas-Junior LH, Ferrari S, Costantino L, Costi MP, Coron RP, Smith TK, Siqueira-Neto JL, McKerrow JH, Cordeiro-da-Silva A. PMID: 26477622.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimals
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Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51. J Med Chem. 2014 Dec 11; 57(23):10162-75.
Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM. PMID: 25393646; PMCID: PMC4266343.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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RPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain. FEBS Lett. 2014 Dec 20; 588(24):4740-8.
Pavani RS, Fernandes C, Perez AM, Vasconcelos EJ, Siqueira-Neto JL, Fontes MR, Cano MI. PMID: 25451229.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Drug discovery for human African trypanosomiasis: identification of novel scaffolds by the newly developed HTS SYBR Green assay for Trypanosoma brucei. J Biomol Screen. 2015 Jan; 20(1):70-81.
Faria J, Moraes CB, Song R, Pascoalino BS, Lee N, Siqueira-Neto JL, Cruz DJ, Parkinson T, Ioset JR, Cordeiro-da-Silva A, Freitas-Junior LH. PMID: 25342146.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Lead identification to clinical candidate selection: drugs for Chagas disease. J Biomol Screen. 2015 Jan; 20(1):101-11.
Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. PMID: 25281737.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency. J Med Chem. 2014 Aug 28; 57(16):6989-7005.
Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM. PMID: 25101801; PMCID: PMC4148169.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimals
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Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a]benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi. Eur J Med Chem. 2014 Sep 12; 84:395-403.
Oh S, Kim S, Kong S, Yang G, Lee N, Han D, Goo J, Siqueira-Neto JL, Freitas-Junior LH, Song R. PMID: 25036797.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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An image-based algorithm for precise and accurate high throughput assessment of drug activity against the human parasite Trypanosoma cruzi. PLoS One. 2014; 9(2):e87188.
Moon S, Siqueira-Neto JL, Moraes CB, Yang G, Kang M, Freitas-Junior LH, Hansen MA. PMID: 24503652; PMCID: PMC3913590.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease. ACS Med Chem Lett. 2014 Feb 13; 5(2):149-53.
Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, Rodriguez A, Palmer MA, Foley M, Schreiber SL, Munoz B. PMID: 24900788; PMCID: PMC4027639.
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PubMed Mentions:
13
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An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages. PLoS Negl Trop Dis. 2012; 6(6):e1671.
Siqueira-Neto JL, Moon S, Jang J, Yang G, Lee C, Moon HK, Chatelain E, Genovesio A, Cechetto J, Freitas-Junior LH. PMID: 22720099; PMCID: PMC3373640.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it? Int J Parasitol Drugs Drug Resist. 2012 Dec; 2:11-9.
Freitas-Junior LH, Chatelain E, Kim HA, Siqueira-Neto JL. PMID: 24533267; PMCID: PMC3862432.
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PubMed Mentions:
87 Fields:
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The Leishmania amazonensis TRF (TTAGGG repeat-binding factor) homologue binds and co-localizes with telomeres. BMC Microbiol. 2010 May 07; 10:136.
da Silva MS, Perez AM, da Silveira Rde C, de Moraes CE, Siqueira-Neto JL, Freitas Lde H, Cano MI. PMID: 20459667; PMCID: PMC2896790.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds. PLoS Negl Trop Dis. 2010 May 04; 4(5):e675.
Siqueira-Neto JL, Song OR, Oh H, Sohn JH, Yang G, Nam J, Jang J, Cechetto J, Lee CB, Moon S, Genovesio A, Chatelain E, Christophe T, Freitas-Junior LH. PMID: 20454559; PMCID: PMC2864270.
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PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCells
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Automated nuclear analysis of Leishmania major telomeric clusters reveals changes in their organization during the parasite's life cycle. PLoS One. 2008 Jun 11; 3(6):e2313.
Dossin Fde M, Dufour A, Dusch E, Siqueira-Neto JL, Moraes CB, Yang GS, Cano MI, Genovesio A, Freitas-Junior LH. PMID: 18545650; PMCID: PMC2396463.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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LaTBP1: a Leishmania amazonensis DNA-binding protein that associates in vivo with telomeres and GT-rich DNA using a Myb-like domain. Arch Biochem Biophys. 2007 Sep 15; 465(2):399-409.
Lira CB, de Siqueira Neto JL, Khater L, Cagliari TC, Peroni LA, dos Reis JR, Ramos CH, Cano MI. PMID: 17678615.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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LaRbp38: a Leishmania amazonensis protein that binds nuclear and kinetoplast DNAs. Biochem Biophys Res Commun. 2007 Jul 06; 358(3):854-60.
Lira CB, Siqueira Neto JL, Giardini MA, Winck FV, Ramos CH, Cano MI. PMID: 17506988.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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The putative telomerase reverse transcriptase component of Leishmania amazonensis: gene cloning and characterization. Parasitol Res. 2006 Apr; 98(5):447-54.
Giardini MA, Lira CB, Conte FF, Camillo LR, de Siqueira Neto JL, Ramos CH, Cano MI. PMID: 16416120.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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| Year | Publications |
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| 2006 | 1 |
| 2007 | 2 |
| 2008 | 1 |
| 2010 | 2 |
| 2012 | 2 |
| 2013 | 1 |
| 2014 | 7 |
| 2015 | 8 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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