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Siqueira-Neto, Jair L.

Title(s)Assistant Professor, School of Pharmacy and Pharmaceutical Science
SchoolHealth Sciences
Address9500 Gilman Drive #0755
La Jolla CA 92093
Phone858-822-5595
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    Collapse Biography 
    Collapse Education and Training
    Institut Pasteur KoreaPost-doctorate2009
    Unicamp, SP - BrazilPh.D. Genetics and Molecular Biology2007Dept. Genetics, Microbiology & Immunology
    Unicamp, SP - BrazilBS Biology2003Institute of Biology

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. ACS Med Chem Lett. 2016 Jan 14; 7(1):77-82. Jones BD, Tochowicz A, Tang Y, Cameron MD, McCall LI, Hirata K, Siqueira-Neto JL, Reed SL, McKerrow JH, Roush WR. PMID: 26819670.
      View in: PubMed   Mentions:
    2. Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. ACS Chem Biol. 2015 Oct 16; 10(10):2373-81. Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach MA, Linington RG. PMID: 26270237.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    3. Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. PLoS Negl Trop Dis. 2015; 9(6):e0003878. Ekins S, de Siqueira-Neto JL, McCall LI, Sarker M, Yadav M, Ponder EL, Kallel EA, Kellar D, Chen S, Arkin M, Bunin BA, McKerrow JH, Talcott C. PMID: 26114876.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    4. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003588. McCall LI, El Aroussi A, Choi JY, Vieira DF, De Muylder G, Johnston JB, Chen S, Kellar D, Siqueira-Neto JL, Roush WR, Podust LM, McKerrow JH. PMID: 25768284.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    5. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrob Agents Chemother. 2015 May; 59(5):2666-77. Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales JĂșnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, de Oliveira RB, Ferreira RS. PMID: 25712353.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    6. Proteomic-based approach to gain insight into reprogramming of THP-1 cells exposed to Leishmania donovani over an early temporal window. Infect Immun. 2015 May; 83(5):1853-68. Singh AK, Pandey RK, Siqueira-Neto JL, Kwon YJ, Freitas-Junior LH, Shaha C, Madhubala R. PMID: 25690103.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    7. Synthesis and Evaluation of DNA Based Quantum Dot Fluorescence In Situ Hybridization (FISH) Probe for Telomere Detection. J Nanosci Nanotechnol. 2015 Feb; 15(2):1708-13. Choi Y, De Siqueira Neto JL, Moraes C, Freitas L, Song R. PMID: 26353719.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Current and Future Chemotherapy for Chagas Disease. Curr Med Chem. 2015; 22(37):4293-312. Gaspar L, Moraes CB, Freitas-Junior LH, Ferrari S, Costantino L, Costi MP, Coron RP, Smith TK, Siqueira-Neto JL, McKerrow JH, Cordeiro-da-Silva A. PMID: 26477622.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    9. Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51. J Med Chem. 2014 Dec 11; 57(23):10162-75. Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM. PMID: 25393646.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. RPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain. FEBS Lett. 2014 Dec 20; 588(24):4740-8. Pavani RS, Fernandes C, Perez AM, Vasconcelos EJ, Siqueira-Neto JL, Fontes MR, Cano MI. PMID: 25451229.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Drug discovery for human African trypanosomiasis: identification of novel scaffolds by the newly developed HTS SYBR Green assay for Trypanosoma brucei. J Biomol Screen. 2015 Jan; 20(1):70-81. Faria J, Moraes CB, Song R, Pascoalino BS, Lee N, Siqueira-Neto JL, Cruz DJ, Parkinson T, Ioset JR, Cordeiro-da-Silva A, Freitas-Junior LH. PMID: 25342146.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    12. Lead identification to clinical candidate selection: drugs for Chagas disease. J Biomol Screen. 2015 Jan; 20(1):101-11. Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. PMID: 25281737.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency. J Med Chem. 2014 Aug 28; 57(16):6989-7005. Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM. PMID: 25101801.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    14. Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a]benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi. Eur J Med Chem. 2014 Sep 12; 84:395-403. Oh S, Kim S, Kong S, Yang G, Lee N, Han D, Goo J, Siqueira-Neto JL, Freitas-Junior LH, Song R. PMID: 25036797.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. An image-based algorithm for precise and accurate high throughput assessment of drug activity against the human parasite Trypanosoma cruzi. PLoS One. 2014; 9(2):e87188. Moon S, Siqueira-Neto JL, Moraes CB, Yang G, Kang M, Freitas-Junior LH, Hansen MA. PMID: 24503652.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    16. Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease. ACS Med Chem Lett. 2014 Feb 13; 5(2):149-53. Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, Rodriguez A, Palmer MA, Foley M, Schreiber SL, Munoz B. PMID: 24900788.
      View in: PubMed   Mentions:
    17. An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages. PLoS Negl Trop Dis. 2012; 6(6):e1671. Siqueira-Neto JL, Moon S, Jang J, Yang G, Lee C, Moon HK, Chatelain E, Genovesio A, Cechetto J, Freitas-Junior LH. PMID: 22720099.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    18. Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it? Int J Parasitol Drugs Drug Resist. 2012 Dec; 2:11-9. Freitas-Junior LH, Chatelain E, Kim HA, Siqueira-Neto JL. PMID: 24533267.
      View in: PubMed   Mentions: 49     Fields:    
    19. The Leishmania amazonensis TRF (TTAGGG repeat-binding factor) homologue binds and co-localizes with telomeres. BMC Microbiol. 2010 May 07; 10:136. da Silva MS, Perez AM, da Silveira Rde C, de Moraes CE, Siqueira-Neto JL, Freitas Lde H, Cano MI. PMID: 20459667.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    20. Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds. PLoS Negl Trop Dis. 2010 May 04; 4(5):e675. Siqueira-Neto JL, Song OR, Oh H, Sohn JH, Yang G, Nam J, Jang J, Cechetto J, Lee CB, Moon S, Genovesio A, Chatelain E, Christophe T, Freitas-Junior LH. PMID: 20454559.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    21. Automated nuclear analysis of Leishmania major telomeric clusters reveals changes in their organization during the parasite's life cycle. PLoS One. 2008 Jun 11; 3(6):e2313. Dossin Fde M, Dufour A, Dusch E, Siqueira-Neto JL, Moraes CB, Yang GS, Cano MI, Genovesio A, Freitas-Junior LH. PMID: 18545650.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    22. LaTBP1: a Leishmania amazonensis DNA-binding protein that associates in vivo with telomeres and GT-rich DNA using a Myb-like domain. Arch Biochem Biophys. 2007 Sep 15; 465(2):399-409. Lira CB, de Siqueira Neto JL, Khater L, Cagliari TC, Peroni LA, dos Reis JR, Ramos CH, Cano MI. PMID: 17678615.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    23. LaRbp38: a Leishmania amazonensis protein that binds nuclear and kinetoplast DNAs. Biochem Biophys Res Commun. 2007 Jul 06; 358(3):854-60. Lira CB, Siqueira Neto JL, Giardini MA, Winck FV, Ramos CH, Cano MI. PMID: 17506988.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    24. The putative telomerase reverse transcriptase component of Leishmania amazonensis: gene cloning and characterization. Parasitol Res. 2006 Apr; 98(5):447-54. Giardini MA, Lira CB, Conte FF, Camillo LR, de Siqueira Neto JL, Ramos CH, Cano MI. PMID: 16416120.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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