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    Edland, Steven

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentFamily Medicine and Public Health
    Address9500 Gilman Drive #0725
    CA La Jolla 92093
    Phone858-246-1250
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      Collapse Overview
      Dr. Edland’s primary research interest is the epidemiology, treatment, and prevention of chronic disease. Prior to joining UCSD, Dr. Edland provided statistical support to a number of nationally recognized epidemiologic investigations of Alzheimer’s disease, including the Consortium the Establish a Registry of Alzheimer’s Disease, the first nationwide longitudinal cohort study of Alzheimer’s disease, the Mayo Clinic medical records-based Olmsted County Rochester Epidemiology Project, the “Kame study” of the prevalence, incidence, and risk factors for dementia and Alzheimer’s disease in the Japanese-American residents of King County, WA, and other NIA program project Alzheimer’s disease model patient registries. Dr. Edland’s expertise in longitudinal analysis is now brought to bear in support of cohort studies and clinical trials administered by the UCSD Department of Neurosciences, where he has a joint appointment.

      Dr. Edland enjoys the collaborative research process and bridging the gap between mathematical statistics and research application, with substantial experience supporting both clinical and bench research, including 25 years of continuous involvement in Alzheimer’s Disease Research Centers (ADRCs), as founding director of the Mayo Clinic ADRC Biostatistics Core, and currently as director of the UCSD ADRC Biostatistics Core. Dr. Edland’s collaborations often evolve into ancillary publication of context-specific statistical methods.

      Dr. Edland’s current active independent research is on the improved design, implementation, and analysis of clinical trials of chronic progressive disease. For example, Dr. Edland is Principal Investigator of an NIA grant titled Optimizing Outcome Measures for Clinical Trials in Pre-Clinical Alzheimer's Disease, which will explore statistical methods of constructing outcome measures more sensitive to Alzheimer’s disease progression and drug treatment effects at the earliest stages of this disease. Dr. Edland serves on Data Safety Monitoring Boards for several multinational clinical trials, is an ad hoc member of the NIH Special Emphasis Panel Alzheimer’s Disease Pilot Clinical Trials (PAR 11-100), and is a standing member of the NIH Neurological, Aging and Musculoskeletal Epidemiology (NAME) Study Section.


      Collapse Research 
      Collapse Research Activities and Funding
      Re-visiting Methods for MCI Diagnosis to Improve Biomarker and Trial Findings
      NIH/NIA R01AG049810Mar 15, 2016 - Feb 28, 2021
      Role: Principal Investigator
      Optimizing Outcome Measures for Clin. Trials in Pre-Clinical Alzheimer's Disease
      NIH/NIA R03AG047580Apr 15, 2015 - Mar 31, 2017
      Role: Principal Investigator
      Optimal design and analysis of AD treatment
      NIH/NIA R03AG034439Aug 15, 2009 - Jul 31, 2012
      Role: Principal Investigator
      Mayo Alzheimer's Disease Research Center
      NIH P50AG016574May 1, 1999 - Apr 30, 2019
      Role: Co-Investigator
      UCSD Alzheimer's Disease Research Center P50
      NIH/NIA P50AG005131Sep 28, 1984 - Mar 31, 2019
      Role: Co-Investigator

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. SD Edland, MC Ard, W Li, L Jiang. Design of pilot studies to inform the construction of composite outcome measures. Alzheimer's & Dementia: Translational Research & Clinical Interventions. 2017; 3(2):213-218.
      2. Edland S, Ard MC, Li W, Jiang L. Design of pilot studies to inform the construction of composite outcome measures. Alzheimers Dement (N Y). 2017 Jun; 3(2):213-218. PMID: 28920073.
        View in: PubMed
      3. Kelley KD, Peavy G, Edland S, Rogers W, Riley DE, Bordelon Y, Standaert D, Reich SG, Litvan I. The Role of Stress as a Risk Factor for Progressive Supranuclear Palsy. J Parkinsons Dis. 2017; 7(2):377-383. PMID: 28409749.
        View in: PubMed
      4. Edland S, Ard MC, Sridhar J, Cobia D, Martersteck A, Mesulam MM, Rogalski EJ. Proof of concept demonstration of optimal composite MRI endpoints for clinical trials. Alzheimers Dement (N Y). 2016 Sep; 2(3):177-181. PMID: 28345017.
        View in: PubMed
      5. Peavy GM, Edland S, Toole BM, Hansen LA, Galasko DR, Mayo AM. Phenotypic differences based on staging of Alzheimer's neuropathology in autopsy-confirmed dementia with Lewy bodies. Parkinsonism Relat Disord. 2016 Oct; 31:72-78. PMID: 27475955.
        View in: PubMed
      6. White LR, Edland S, Hemmy LS, Montine KS, Zarow C, Sonnen JA, Uyehara-Lock JH, Gelber RP, Ross GW, Petrovitch H, Masaki KH, Lim KO, Launer LJ, Montine TJ. Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies. Neurology. 2016 Mar 15; 86(11):1000-8. PMID: 26888993; PMCID: PMC4799714 [Available on 03/15/17].
      7. Liu L, Edland S, Myers MG, Hofstetter CR, Al-Delaimy WK. Smoking prevalence in urban and rural populations: findings from California between 2001 and 2012. Am J Drug Alcohol Abuse. 2016 Mar; 42(2):152-61. PMID: 26821213.
        View in: PubMed
      8. Calvo RY, Lindsay SP, Edland S, Macera CA, Wingard DL, Ohno-Machado L, Sise MJ. The differential associations of preexisting conditions with trauma-related outcomes in the presence of competing risks. Injury. 2016 Mar; 47(3):677-84. PMID: 26684173.
        View in: PubMed
      9. Ard MC, Raghavan N, Edland S. Optimal composite scores for longitudinal clinical trials under the linear mixed effects model. Pharm Stat. 2015 Sep-Oct; 14(5):418-26. PMID: 26223663.
        View in: PubMed
      10. Strong DR, Myers M, Linke S, Leas E, Hofstetter R, Edland S, Al-Delaimy WK. Gender differences influence overweight smokers' experimentation with electronic nicotine delivery systems. Addict Behav. 2015 Oct; 49:20-5. PMID: 26036665; PMCID: PMC4478105.
      11. Nation DA, Edmonds EC, Bangen KJ, Delano-Wood L, Scanlon BK, Han SD, Edland S, Salmon DP, Galasko DR, Bondi MW. Pulse pressure in relation to tau-mediated neurodegeneration, cerebral amyloidosis, and progression to dementia in very old adults. JAMA Neurol. 2015 May; 72(5):546-53. PMID: 25822631; PMCID: PMC4428938.
      12. Young JE, Boulanger-Weill J, Williams DA, Woodruff G, Buen F, Revilla AC, Herrera C, Israel MA, Yuan SH, Edland S, Goldstein LS. Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells. Cell Stem Cell. 2015 Apr 02; 16(4):373-85. PMID: 25772071; PMCID: PMC4388804.
      13. Donohue MC, Moghadam SH, Roe AD, Sun CK, Edland S, Thomas RG, Petersen RC, Sano M, Galasko D, Aisen PS, Rissman RA. Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials. Alzheimers Dement. 2015 Sep; 11(9):1069-79. PMID: 25301682; PMCID: PMC4387108.
      14. Smith SD, Marrone L, Gomez A, Johnson ML, Edland S, Beck E. Clinical outcomes of diabetic patients at a student-run free clinic project. Fam Med. 2014 Mar; 46(3):198-203. PMID: 24652638.
        View in: PubMed
      15. Leas EC, Zablocki RW, Edland S, Al-Delaimy WK. Smokers who report smoking but do not consider themselves smokers: a phenomenon in need of further attention. Tob Control. 2015 Jul; 24(4):400-3. PMID: 24500273.
        View in: PubMed
      16. Zablocki RW, Edland S, Myers MG, Strong DR, Hofstetter CR, Al-Delaimy WK. Smoking ban policies and their influence on smoking behaviors among current California smokers: a population-based study. Prev Med. 2014 Feb; 59:73-8. PMID: 24291748.
        View in: PubMed
      17. Nation DA, Edland S, Bondi MW, Salmon DP, Delano-Wood L, Peskind ER, Quinn JF, Galasko DR. Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults. Neurology. 2013 Dec 03; 81(23):2024-7. PMID: 24225352; PMCID: PMC3854831.
      18. Myers MG, Doran NM, Edland S, Schweizer CA, Wall TL. Cigarette smoking initiation during college predicts future alcohol involvement: a matched-samples study. J Stud Alcohol Drugs. 2013 Nov; 74(6):909-16. PMID: 24172118.
        View in: PubMed
      19. Campos M, Edland S, Peavy GM. Exploratory study of apolipoprotein E e4 genotype and risk of Alzheimer's disease in Mexican Hispanics. J Am Geriatr Soc. 2013 Jun; 61(6):1038-40. PMID: 23772735; PMCID: PMC3694500.
      20. Nagle BJ, Usita PM, Edland S. United States medical students' knowledge of Alzheimer disease. J Educ Eval Health Prof. 2013; 10:4. PMID: 23750313; PMCID: PMC3674970.
      21. Sherzai A, Edland S, Masliah E, Hansen L, Pizzo DP, Sherzai A, Corey-Bloom J. Spongiform change in dementia with Lewy bodies and Alzheimer disease. Alzheimer Dis Assoc Disord. 2013 Apr-Jun; 27(2):157-61. PMID: 22546782.
        View in: PubMed
      22. Ard MC, Galasko DR, Edland S. Improved statistical power of Alzheimer clinical trials by item-response theory: proof of concept by application to the activities of daily living scale. Alzheimer Dis Assoc Disord. 2013 Apr-Jun; 27(2):187-91. PMID: 22874658; PMCID: PMC4362713.
      23. Peavy GM, Salmon DP, Edland S, Tam S, Hansen LA, Masliah E, Galasko D, Hamilton JM. Neuropsychiatric features of frontal lobe dysfunction in autopsy-confirmed patients with lewy bodies and "pure" Alzheimer disease. Am J Geriatr Psychiatry. 2013 Jun; 21(6):509-19. PMID: 23567425; PMCID: PMC3664517.
      24. Peavy GM, Santiago DP, Edland S. Subjective memory complaints are associated with diurnal measures of salivary cortisol in cognitively intact older adults. Am J Geriatr Psychiatry. 2013 Sep; 21(9):925-8. PMID: 23567387; PMCID: PMC3516632.
      25. Myers MG, Edland S, Hofstetter CR, Al-Delaimy WK. Perceived price sensitivity by ethnicity and smoking frequency among California Hispanic and non-Hispanic white smokers. Nicotine Tob Res. 2013 Jun; 15(6):1069-74. PMID: 23136268.
        View in: PubMed
      26. Brody BL, Field LC, Roch-Levecq AC, Depp C, Edland S, Minasyan L, Brown SI. Computer use among patients with age-related macular degeneration. Ophthalmic Epidemiol. 2012 Aug; 19(4):190-5. PMID: 22775273.
        View in: PubMed
      27. Pillai JA, Hansen LA, Masliah E, Goldstein JL, Edland S, Corey-Bloom J. Clinical severity of Huntington's disease does not always correlate with neuropathologic stage. Mov Disord. 2012 Aug; 27(9):1099-103. PMID: 22674458; PMCID: PMC3412903.
      28. Tang Y, Scott DA, Das U, Edland S, Radomski K, Koo EH, Roy S. Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid ß-protein oligomers. Traffic. 2012 May; 13(5):681-93. PMID: 22309053; PMCID: PMC3593673.
      29. Brody BL, Field LC, Roch-Levecq AC, Moutier CY, Edland S, Brown SI. Treatment of depression associated with age-related macular degeneration: a double-blind, randomized, controlled study. Ann Clin Psychiatry. 2011 Nov; 23(4):277-84. PMID: 22073385.
        View in: PubMed
      30. Edland S, Galasko DR. Fractional synthesis and clearance rates for amyloid ß. Nat Med. 2011 Oct 11; 17(10):1178-9; author reply 1179-80. PMID: 21988985.
        View in: PubMed
      31. Smith JR, Edland S, Novotny TE, Hofstetter CR, White MM, Lindsay SP, Al-Delaimy WK. Increasing hookah use in California. Am J Public Health. 2011 Oct; 101(10):1876-9. PMID: 21852640; PMCID: PMC3222344.
      32. Smith JR, Novotny TE, Edland S, Hofstetter CR, Lindsay SP, Al-Delaimy WK. Determinants of hookah use among high school students. Nicotine Tob Res. 2011 Jul; 13(7):565-72. PMID: 21454909.
        View in: PubMed
      33. Ard MC, Edland S. Power calculations for clinical trials in Alzheimer's disease. J Alzheimers Dis. 2011; 26 Suppl 3:369-77. PMID: 21971476; PMCID: PMC3568927.
      34. Ashford JW, Salehi A, Furst A, Bayley P, Frisoni GB, Jack CR, Sabri O, Adamson MM, Coburn KL, Olichney J, Schuff N, Spielman D, Edland S, Black S, Rosen A, Kennedy D, Weiner M, Perry G. Imaging the Alzheimer brain. J Alzheimers Dis. 2011; 26 Suppl 3:1-27. PMID: 21971448; PMCID: PMC3760773.
      35. McEvoy LK, Edland S, Holland D, Hagler DJ, Roddey JC, Fennema-Notestine C, Salmon DP, Koyama AK, Aisen PS, Brewer JB, Dale AM. Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease. Alzheimer Dis Assoc Disord. 2010 Jul-Sep; 24(3):269-77. PMID: 20683184; PMCID: PMC2929320.
      36. Edland S, Emond JA, Aisen PS, Petersen RC. NIA-funded Alzheimer centers are more efficient than commercial clinical recruitment sites for conducting secondary prevention trials of dementia. Alzheimer Dis Assoc Disord. 2010 Apr-Jun; 24(2):159-64. PMID: 20505433; PMCID: PMC2922976.
      37. Vozdolska R, Sano M, Aisen P, Edland S. The net effect of alternative allocation ratios on recruitment time and trial cost. Clin Trials. 2009 Apr; 6(2):126-32. PMID: 19342464; PMCID: PMC2864093.
      38. Ma QL, Galasko DR, Ringman JM, Vinters HV, Edland S, Pomakian J, Ubeda OJ, Rosario ER, Teter B, Frautschy SA, Cole GM. Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid. Arch Neurol. 2009 Apr; 66(4):448-57. PMID: 19364929; PMCID: PMC2742778.
      39. Ferris SH, Aisen PS, Cummings J, Galasko D, Salmon DP, Schneider L, Sano M, Whitehouse PJ, Edland S, Thal LJ. ADCS Prevention Instrument Project: overview and initial results. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S109-23. PMID: 17135805.
        View in: PubMed
      40. Salmon DP, Cummings JL, Jin S, Sano M, Sperling RA, Zamrini E, Petersen RC, Edland S, Thal LJ, Ferris SH. ADCS Prevention Instrument Project: development of a brief verbal memory test for primary prevention clinical trials. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S139-46. PMID: 17135807.
        View in: PubMed
      41. Galasko D, Bennett DA, Sano M, Marson D, Kaye J, Edland S. ADCS Prevention Instrument Project: assessment of instrumental activities of daily living for community-dwelling elderly individuals in dementia prevention clinical trials. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S152-69. PMID: 17135809.
        View in: PubMed
      42. Patterson MB, Whitehouse PJ, Edland S, Sami SA, Sano M, Smyth K, Weiner MF. ADCS Prevention Instrument Project: quality of life assessment (QOL). Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S179-90. PMID: 17135811.
        View in: PubMed
      43. Sano M, Zhu CW, Whitehouse PJ, Edland S, Jin S, Ernstrom K, Thomas RG, Thal LJ, Ferris SH. ADCS Prevention Instrument Project: pharmacoeconomics: assessing health-related resource use among healthy elderly. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S191-202. PMID: 17135812; PMCID: PMC3229195.
      44. Whitehouse PJ, Rajcan JL, Sami SA, Patterson MB, Smyth KA, Edland S, George DR. ADCS Prevention Instrument Project: pilot testing of a book club as a psychosocial intervention and recruitment and retention strategy. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S203-8. PMID: 17135813.
        View in: PubMed
      45. Knopman DS, Petersen RC, Cha RH, Edland S, Rocca WA. Incidence and causes of nondegenerative nonvascular dementia: a population-based study. Arch Neurol. 2006 Feb; 63(2):218-21. PMID: 16476810.
        View in: PubMed
      46. Myllykangas L, Wavrant-De Vrièze F, Polvikoski T, Notkola IL, Sulkava R, Niinistö L, Edland S, Arepalli S, Adighibe O, Compton D, Hardy J, Haltia M, Tienari PJ. Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study. J Neurol Sci. 2005 Sep 15; 236(1-2):17-24. PMID: 16023140.
        View in: PubMed
      47. Tsuang D, Simpson KL, Li G, Barnhart RL, Edland S, Bowen J, McCormick W, Teri L, Nochlin D, Larson EB, Thompson ML, Leverenz JB. Evaluation of selection bias in an incident-based dementia autopsy case series. Alzheimer Dis Assoc Disord. 2005 Apr-Jun; 19(2):67-73. PMID: 15942323; PMCID: PMC1524825.
      48. Josephs KA, Tang-Wai DF, Edland S, Knopman DS, Dickson DW, Parisi JE, Petersen RC, Jack CR, Boeve BF. Correlation between antemortem magnetic resonance imaging findings and pathologically confirmed corticobasal degeneration. Arch Neurol. 2004 Dec; 61(12):1881-4. PMID: 15596608.
        View in: PubMed
      49. Ensenauer R, Vockley J, Willard JM, Huey JC, Sass JO, Edland S, Burton BK, Berry SA, Santer R, Grünert S, Koch HG, Marquardt I, Rinaldo P, Hahn S, Matern D. A common mutation is associated with a mild, potentially asymptomatic phenotype in patients with isovaleric acidemia diagnosed by newborn screening. Am J Hum Genet. 2004 Dec; 75(6):1136-42. PMID: 15486829; PMCID: PMC1182150.
      50. Geda YE, Smith GE, Knopman DS, Boeve BF, Tangalos EG, Ivnik RJ, Mrazek DA, Edland S, Petersen RC. De novo genesis of neuropsychiatric symptoms in mild cognitive impairment (MCI). Int Psychogeriatr. 2004 Mar; 16(1):51-60. PMID: 15190996.
        View in: PubMed
      51. Edland S, Slager S, Farrer M. Genetic association studies in Alzheimer's disease research: challenges and opportunities. Stat Med. 2004 Jan 30; 23(2):169-78. PMID: 14716719.
        View in: PubMed
      52. Edland S. Insulin-degrading enzyme, apolipoprotein E, and Alzheimer's disease. J Mol Neurosci. 2004; 23(3):213-7. PMID: 15181249.
        View in: PubMed
      53. Tang-Wai DF, Knopman DS, Geda YE, Edland S, Smith GE, Ivnik RJ, Tangalos EG, Boeve BF, Petersen RC. Comparison of the short test of mental status and the mini-mental state examination in mild cognitive impairment. Arch Neurol. 2003 Dec; 60(12):1777-81. PMID: 14676056.
        View in: PubMed
      54. Kantarci K, Reynolds G, Petersen RC, Boeve BF, Knopman DS, Edland S, Smith GE, Ivnik RJ, Tangalos EG, Jack CR. Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. AJNR Am J Neuroradiol. 2003 May; 24(5):843-9. PMID: 12748083.
        View in: PubMed
      55. Knopman DS, Parisi JE, Boeve BF, Cha RH, Apaydin H, Salviati A, Edland S, Rocca WA. Vascular dementia in a population-based autopsy study. Arch Neurol. 2003 Apr; 60(4):569-75. PMID: 12707071.
        View in: PubMed
      56. Knopman DS, Rocca WA, Cha RH, Edland S, Kokmen E. Survival study of vascular dementia in Rochester, Minnesota. Arch Neurol. 2003 Jan; 60(1):85-90. PMID: 12533093.
        View in: PubMed
      57. Edland S, Rocca WA, Petersen RC, Cha RH, Kokmen E. Dementia and Alzheimer disease incidence rates do not vary by sex in Rochester, Minn. Arch Neurol. 2002 Oct; 59(10):1589-93. PMID: 12374497.
        View in: PubMed
      58. Knopman DS, Rocca WA, Cha RH, Edland S, Kokmen E. Incidence of vascular dementia in Rochester, Minn, 1985-1989. Arch Neurol. 2002 Oct; 59(10):1605-10. PMID: 12374499.
        View in: PubMed
      59. Leverenz JB, Agustin CM, Tsuang D, Peskind ER, Edland S, Nochlin D, DiGiacomo L, Bowen JD, McCormick WC, Teri L, Raskind MA, Kukull WA, Larson EB. Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study. Arch Neurol. 2002 Jul; 59(7):1099-106. PMID: 12117357.
        View in: PubMed
      60. Kantarci K, Xu Y, Shiung MM, O'Brien PC, Cha RH, Smith GE, Ivnik RJ, Boeve BF, Edland S, Kokmen E, Tangalos EG, Petersen RC, Jack CR. Comparative diagnostic utility of different MR modalities in mild cognitive impairment and Alzheimer's disease. Dement Geriatr Cogn Disord. 2002; 14(4):198-207. PMID: 12411762; PMCID: PMC2796574.
      61. Edland S, Tobe VO, Rieder MJ, Bowen JD, McCormick W, Teri L, Schellenberg GD, Larson EB, Nickerson DA, Kukull WA. Mitochondrial genetic variants and Alzheimer disease: a case-control study of the T4336C and G5460A variants. Alzheimer Dis Assoc Disord. 2002 Jan-Mar; 16(1):1-7. PMID: 11882743.
        View in: PubMed
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