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    John Kelsoe

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPsychiatry
    Address9500 Gilman Drive #0689
    CA La Jolla 92093
    Phone858-534-5927
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      Biography

      Dr. Kelsoe graduated from medical school at the University of Alabama, Birmingham in 1981. He completed internship training at Washington University in St. Louis and psychiatry residency at UC San Diego. He then went to the National Institute of Mental Health in Bethesda, Maryland for 4 years and returned to San Diego to join the Department of Psychiatry faculty in 1989.

      Research Interests

      Dr. Kelsoe’s longstanding research focus has been the genetics of psychiatric illness, bipolar disorder in particular. Over the past 20 years, his work has been focused on using a variety of molecular genetic methods to identify the specific genes that predispose to bipolar disorder. He has pursued this primarily by using positional cloning methods such as linkage and association in families in which the illness is genetically transmitted. He has also employed animal models of bipolar disorder in order to identify possible candidate genes that can then be tested in clinical populations. This approach has led to the recent identification of the gene for G protein receptor kinase 3 (GRK3) as a likely gene for bipolar disorder on chromosome 22. Dr. Kelsoe is currently actively engaged in genome wide association studies of bipolar disorder. He directs the Bipolar Genome Study (BiGS) which is a 13-site consortium focused on identifying genes for bipolar disorder and their relationship to clinical symptoms. He also co-directs the Psychiatric GWAS Consortium for Bipolar Disorder (PGC-BD) which is an international collaborative effort designed to identify genes for bipolar disorder in a sample of over 10,000 patients. These large exciting new technological approaches promise great advances in understanding the causes of bipolar disorder.

      Clinical Information

      Dr. Kelsoe’s primary clinical focus is the treatment of refractory mood disorders. He is the Medical Director of the STEP Clinic at the VA Hospital where they specialize in the treatment of chronic and refractory mood disorders. Patients at this clinic receive a thorough diagnostic evaluation and are eligible to participate in longitudinal research studies of the ability of genes to predict course, outcome, and treatment response.


      Collapse Research 
      Collapse Research Activities and Funding
      The Bipolar Genome Study
      NIH/NIMH R01MH094483Jul 1, 2012 - Apr 30, 2015
      Role: Principal Investigator
      Genetic Predictors of Lithium Response in Bipolar Disorder
      VA I01CX000363Oct 1, 2010 - Sep 30, 2015
      Role: Principal Investigator
      Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder
      NIH/NIMH U01MH092758Sep 10, 2010 - May 31, 2015
      Role: Principal Investigator
      Analysis of Whole Genome Association Data for Bipolar Disorder
      NIH/NIMH R01MH081804Sep 27, 2007 - Sep 26, 2009
      Role: Principal Investigator
      Genomic Association Study of Bipolar Disorder
      NIH/NIMH R01MH078151Aug 1, 2007 - May 31, 2011
      Role: Principal Investigator
      Genomic studies of bipolar disorder and chromosome 22
      NIH/NIMH R01MH068503Apr 1, 2004 - Jan 31, 2010
      Role: Principal Investigator
      Microarray studies of amphetamine models of psychosis
      NIH/NIDA R01DA013769Sep 30, 2001 - Jun 30, 2004
      Role: Principal Investigator
      Collaborative Genomic Study of Bipolar Disorder
      NIH/NIMH R01MH059567Sep 30, 1998 - Nov 30, 2008
      Role: Principal Investigator
      GENETIC LINKAGE STUDIES OF BIPOLAR AFFECTIVE DISORDER
      NIH/NIMH R29MH047612Mar 1, 1992 - Feb 28, 1997
      Role: Principal Investigator
      Fellowship on Biological Psychiatry and Neuroscience
      NIH/NIMH T32MH018399Jul 15, 1986 - Jun 30, 2022
      Role: Principal Investigator
      PSYCHOBIOLOGICAL STUDY OF PSYCHIATRIC DISORDERS
      NIH/NIMH P30MH030914Sep 29, 1977 - Dec 31, 2003
      Role: Principal Investigator
      General Clinical Research Center
      NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Qiu F, Akiskal HS, Kelsoe J, Greenwood TA. Factor analysis of temperament and personality traits in bipolar patients: Correlates with comorbidity and disorder severity. J Affect Disord. 2016 Oct 2; 207:282-290. PMID: 27741464.
        View in: PubMed
      2. Voegeli G, Ramoz N, Shekhtman T, Courtet P, Gorwood P, Kelsoe J. Neurotrophin Genes and Antidepressant-Worsening Suicidal Ideation: A Prospective Case-Control Study. Int J Neuropsychopharmacol. 2016 Jul 4. PMID: 27378793.
        View in: PubMed
      3. Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH, Bhattacharjee A, Brennand KJ, Burdick KE, Calabrese JR, Calkin CV, Claasen A, Coryell WH, Craig D, DeModena A, Frye M, Gage FH, Gao K, Garnham J, Gershon E, Jakobsen P, Leckband SG, McCarthy MJ, McInnis MG, Maihofer AX, Mertens J, Morken G, Nievergelt CM, Nurnberger J, Pham S, Schoeyen H, Shekhtman T, Shilling PD, Szelinger S, Tarwater B, Yao J, Zandi PP, Kelsoe J. The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry. 2016; 16(1):129. PMID: 27150464.
        View in: PubMed
      4. Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Oedegaard KJ, McCarthy MJ, Zandi PP, Alda M, Nievergelt CM. Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2016 Feb 11; 530(7589):242. PMID: 26605530.
        View in: PubMed
      5. Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Ødegaard KJ, McCarthy MJ, Zandi PP, Alba M, Nievergelt CM. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2015 Nov 5; 527(7576):95-9. PMID: 26524527.
        View in: PubMed
      6. McCarthy MJ, Le Roux MJ, Wei H, Beesley S, Kelsoe J, Welsh DK. Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms. Neuropharmacology. 2016 Feb; 101:439-48. PMID: 26476274.
        View in: PubMed
      7. Liu X. A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region. J Affect Disord. 2016 Jan 1; 189:141-9. PMID: 26433762.
        View in: PubMed
      8. Ji B, Higa KK, Kelsoe J, Zhou X. Over-expression of XIST, the Master Gene for X Chromosome Inactivation, in Females With Major Affective Disorders. EBioMedicine. 2015 Aug; 2(8):907-16. PMID: 26425698.
        View in: PubMed
      9. Burton CZ, Vella L, Kelsoe J, Bilder RM, Twamley EW. Catechol-O-methyltransferase genotype and response to Compensatory Cognitive Training in outpatients with schizophrenia. Psychiatr Genet. 2015 Jun; 25(3):131-4. PMID: 25748092.
        View in: PubMed
      10. Ament SA, Szelinger S, Glusman G, Ashworth J, Hou L, Akula N, Shekhtman T, Badner JA, Brunkow ME, Mauldin DE, Stittrich AB, Rouleau K, Detera-Wadleigh SD, Nurnberger JI, Edenberg HJ, Gershon ES, Schork N. Rare variants in neuronal excitability genes influence risk for bipolar disorder. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3576-81. PMID: 25730879.
        View in: PubMed
      11. Kripke DF, Klimecki WT, Nievergelt CM, Rex KM, Murray SS, Shekhtman T, Tranah GJ, Loving RT, Lee HJ, Rhee MK, Shadan FF, Poceta JS, Jamil SM, Kline LE, Kelsoe J. Circadian polymorphisms in night owls, in bipolars, and in non-24-hour sleep cycles. Psychiatry Investig. 2014 Oct; 11(4):345-62. PMID: 25395965.
        View in: PubMed
      12. Jacobsen KK, Nievergelt CM, Zayats T, Greenwood TA, Anttila V, Akiskal HS. Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder. J Affect Disord. 2015 Feb 1; 172:453-61. PMID: 25451450.
        View in: PubMed
      13. Twamley EW, Hua JP, Burton CZ, Vella L, Chinh K, Bilder RM, Kelsoe J. Effects of COMT genotype on cognitive ability and functional capacity in individuals with schizophrenia. Schizophr Res. 2014 Oct; 159(1):114-7. PMID: 25139113.
        View in: PubMed
      14. McCarthy MJ, Liang S, Spadoni AD, Kelsoe J, Simmons AN. Whole brain expression of bipolar disorder associated genes: structural and genetic analyses. PLoS One. 2014; 9(6):e100204. PMID: 24941232.
        View in: PubMed
      15. Greenwood TA, Badner JA, Byerley W, Keck PE, McElroy SL, Remick RA, Dessa Sadovnick A, Kelsoe J. Heritability and linkage analysis of personality in bipolar disorder. J Affect Disord. 2013 Nov; 151(2):748-55. PMID: 23972719.
        View in: PubMed
      16. Greenwood TA, Badner JA, Byerley W, Keck PE, McElroy SL, Remick RA, Sadovnick AD, Akiskal HS, Kelsoe J. Heritability and genome-wide SNP linkage analysis of temperament in bipolar disorder. J Affect Disord. 2013 Sep 25; 150(3):1031-40. PMID: 23759419.
        View in: PubMed
      17. Schork AJ, Thompson WK, Pham P, Torkamani A, Roddey JC, Sullivan PF, Kelsoe J, O'Donovan MC, Furberg H. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genet. 2013 Apr; 9(4):e1003449. PMID: 23637621.
        View in: PubMed
      18. Kripke DF, Nievergelt CM, Tranah GJ, Murray SS, Rex KM, Grizas AP, Hahn EK, Lee HJ, Kelsoe J, Kline LE. FMR1, circadian genes and depression: suggestive associations or false discovery? J Circadian Rhythms. 2013; 11(1):3. PMID: 23521777.
        View in: PubMed
      19. Greenwood TA. Genome-wide association study of irritable vs. elated mania suggests genetic differences between clinical subtypes of bipolar disorder. PLoS One. 2013; 8(1):e53804. PMID: 23326512.
        View in: PubMed
      20. Greenwood TA, Joo EJ, Shekhtman T, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Kelsoe J. Association of dopamine transporter gene variants with childhood ADHD features in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2013 Mar; 162B(2):137-45. PMID: 23255304.
        View in: PubMed
      21. Nissen S, Liang S, Shehktman T, Kelsoe J. Evidence for association of bipolar disorder to haplotypes in the 22q12.3 region near the genes stargazin, IFT27 and parvalbumin. Am J Med Genet B Neuropsychiatr Genet. 2012 Dec; 159B(8):941-50. PMID: 23038240.
        View in: PubMed
      22. Lee HJ, Woo HG, Greenwood TA, Kripke DF, Kelsoe J. A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder. J Affect Disord. 2013 Feb 20; 145(2):200-7. PMID: 22925353.
        View in: PubMed
      23. Greenwood TA, Akiskal HS, Akiskal KK. Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. Biol Psychiatry. 2012 Aug 15; 72(4):303-10. PMID: 22365631.
        View in: PubMed
      24. McCarthy MJ, Nievergelt CM, Kelsoe J, Welsh DK. A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response. PLoS One. 2012; 7(2):e32091. PMID: 22384149.
        View in: PubMed
      25. Greenwood TA, Nievergelt CM, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Shekhtman T, McKinney R, Kelsoe J. Further evidence for linkage of bipolar disorder to chromosomes 6 and 17 in a new independent pedigree series. Bipolar Disord. 2012 Feb; 14(1):71-9. PMID: 22329474.
        View in: PubMed
      26. Malhotra D, McCarthy S, Michaelson JJ, Vacic V, Burdick KE, Yoon S, Cichon S, Corvin A, Gary S, Gershon ES, Gill M, Karayiorgou M, Kelsoe J, Krastoshevsky O, Krause V, Leibenluft E, Levy DL, Makarov V, Bhandari A, Malhotra AK, McMahon FJ, Nöthen MM, Potash JB, Rietschel M, Schulze TG, Sebat J. High frequencies of de novo CNVs in bipolar disorder and schizophrenia. Neuron. 2011 Dec 22; 72(6):951-63. PMID: 22196331.
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      27. Kripke DF, Nievergelt CM, Tranah GJ, Murray SS, McCarthy MJ, Rex KM, Parimi N, Kelsoe J. Polymorphisms in melatonin synthesis pathways: possible influences on depression. J Circadian Rhythms. 2011; 9:8. PMID: 21827647.
        View in: PubMed
      28. Smith EN, Koller DL, Panganiban C, Szelinger S, Zhang P, Badner JA, Barrett TB, Berrettini WH, Bloss CS, Byerley W, Coryell W, Edenberg HJ, Foroud T, Gershon ES, Greenwood TA, Guo Y, Hipolito M, Keating BJ, Lawson WB, Liu C, Mahon PB, McInnis MG, McMahon FJ, McKinney R, Murray SS, Nievergelt CM, Nurnberger JI, Nwulia EA, Potash JB, Rice J, Schulze TG, Scheftner WA, Shilling PD, Zandi PP, Zöllner S, Craig DW, Schork NJ, Kelsoe J. Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. PLoS Genet. 2011 Jun; 7(6):e1002134. PMID: 21738484.
        View in: PubMed
      29. Fountoulakis KN, Kelsoe J, Akiskal H. Receptor targets for antidepressant therapy in bipolar disorder: an overview. J Affect Disord. 2012 May; 138(3):222-38. PMID: 21601292.
        View in: PubMed
      30. Lee HJ, Rex KM, Nievergelt CM, Kelsoe J, Kripke DF. Delayed sleep phase syndrome is related to seasonal affective disorder. J Affect Disord. 2011 Oct; 133(3):573-9. PMID: 21601293.
        View in: PubMed
      31. Greenwood TA, Lazzeroni LC, Murray SS, Cadenhead KS, Calkins ME, Dobie DJ, Green MF, Gur RE, Gur RC, Hardiman G, Kelsoe J, Leonard S, Light GA, Nuechterlein KH, Olincy A, Radant AD, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Freedman R, Braff DL. Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia. Am J Psychiatry. 2011 Sep; 168(9):930-46. PMID: 21498463.
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      32. McCarthy MJ, Leckband SG, Kelsoe J. Pharmacogenetics of lithium response in bipolar disorder. Pharmacogenomics. 2010 Oct; 11(10):1439-65. PMID: 21047205.
        View in: PubMed
      33. Zhou X, Nie Z, Roberts A, Zhang D, Sebat J, Malhotra D, Kelsoe J, Geyer MA. Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders. Hum Mol Genet. 2010 Oct 1; 19(19):3797-805. PMID: 20634195.
        View in: PubMed
      34. Joo EJ, Greenwood TA, Schork N, McKinney RA, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Kelsoe J. Suggestive evidence for linkage of ADHD features in bipolar disorder to chromosome 10p14. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5; 153B(1):260-8. PMID: 19603423.
        View in: PubMed
      35. McCarthy MJ, Barrett TB, Nissen S, Kelsoe J, Turner EE. Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients. J Psychiatr Res. 2010 Mar; 44(4):201-8. PMID: 19766236.
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      36. Wu JC, Kelsoe J, Schachat C, Bunney BG, DeModena A, Golshan S, Gillin JC, Potkin SG, Bunney WE. Rapid and sustained antidepressant response with sleep deprivation and chronotherapy in bipolar disorder. Biol Psychiatry. 2009 Aug 1; 66(3):298-301. PMID: 19358978.
        View in: PubMed
      37. Zhou X, Tang W, Greenwood TA, Guo S, He L, Geyer MA, Kelsoe J. Transcription factor SP4 is a susceptibility gene for bipolar disorder. PLoS One. 2009; 4(4):e5196. PMID: 19401786.
        View in: PubMed
      38. Kripke DF, Nievergelt CM, Joo E, Shekhtman T, Kelsoe J. Circadian polymorphisms associated with affective disorders. J Circadian Rhythms. 2009; 7:2. PMID: 19166596.
        View in: PubMed
      39. Liu L, Foroud T, Xuei X, Berrettini W, Byerley W, Coryell W, El-Mallakh R, Gershon ES, Kelsoe J, Lawson WB, MacKinnon DF, McInnis M, McMahon FJ, Murphy DL, Rice J, Scheftner W, Zandi PP, Lohoff FW, Niculescu AB, Meyer ET, Edenberg HJ, Nurnberger JI. Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder. Psychiatr Genet. 2008 Dec; 18(6):267-74. PMID: 19018231.
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      40. Ross J, Berrettini W, Coryell W, Gershon ES, Badner JA, Kelsoe J, McInnis MG, McMahon FJ, Murphy DL, Nurnberger JI, Foroud T, Rice JP, Scheftner WB, Zandi P, Edenberg H, Byerley W. Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20. Psychiatr Genet. 2008 Aug; 18(4):191-8. PMID: 18628681.
        View in: PubMed
      41. Kripke DF, Rex KM, Ancoli-Israel S, Nievergelt CM, Klimecki W, Kelsoe J. Delayed sleep phase cases and controls. J Circadian Rhythms. 2008; 6:6. PMID: 18445295.
        View in: PubMed
      42. Zhou X, Barrett TB, Kelsoe J. Promoter variant in the GRK3 gene associated with bipolar disorder alters gene expression. Biol Psychiatry. 2008 Jul 15; 64(2):104-10. PMID: 18359007.
        View in: PubMed
      43. Barrett TB, Emberton JE, Nievergelt CM, Liang SG, Hauger RL, Eskin E, Schork NJ, Kelsoe J. Further evidence for association of GRK3 to bipolar disorder suggests a second disease mutation. Psychiatr Genet. 2007 Dec; 17(6):315-22. PMID: 18075471.
        View in: PubMed
      44. Shilling PD, Kuczenski R, Segal DS, Barrett TB, Kelsoe J. Differential regulation of immediate-early gene expression in the prefrontal cortex of rats with a high vs low behavioral response to methamphetamine. Neuropsychopharmacology. 2006 Nov; 31(11):2359-67. PMID: 16855532.
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      45. Nievergelt CM, Kripke DF, Barrett TB, Burg E, Remick RA, Sadovnick AD, McElroy SL, Keck PE, Schork NJ, Kelsoe J. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2006 Apr 5; 141B(3):234-41. PMID: 16528748.
        View in: PubMed
      46. Kimmel RJ, Kovacs I, Vrabel C, Wood B, Schalling M, Kelsoe J. Cosegregation of bipolar disorder and autosomal-dominant medullary cystic kidney disease in a large family. Am J Psychiatry. 2005 Oct; 162(10):1972-4. PMID: 16199849.
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      47. Nievergelt CM, Kripke DF, Remick RA, Sadovnick AD, McElroy SL, Keck PE, Kelsoe J. Examination of the clock gene Cryptochrome 1 in bipolar disorder: mutational analysis and absence of evidence for linkage or association. Psychiatr Genet. 2005 Mar; 15(1):45-52. PMID: 15722957.
        View in: PubMed
      48. Akiskal HS, Mendlowicz MV, Jean-Louis G, Rapaport MH, Kelsoe J, Gillin JC, Smith TL. TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperament. J Affect Disord. 2005 Mar; 85(1-2):45-52. PMID: 15780675.
        View in: PubMed
      49. Mendlowicz MV, Jean-Louis G, Kelsoe J, Akiskal HS. A comparison of recovered bipolar patients, healthy relatives of bipolar probands, and normal controls using the short TEMPS-A. J Affect Disord. 2005 Mar; 85(1-2):147-51. PMID: 15780685.
        View in: PubMed
      50. Evans L, Akiskal HS, Keck PE, McElroy SL, Sadovnick AD, Remick RA, Kelsoe J. Familiality of temperament in bipolar disorder: support for a genetic spectrum. J Affect Disord. 2005 Mar; 85(1-2):153-68. PMID: 15780686.
        View in: PubMed
      51. Mendlowicz MV, Akiskal HS, Kelsoe J, Rapaport MH, Jean-Louis G, Gillin JC. Temperament in the clinical differentiation of depressed bipolar and unipolar major depressive patients. J Affect Disord. 2005 Feb; 84(2-3):219-23. PMID: 15708419.
        View in: PubMed
      52. Haynes PL, McQuaid JR, Kelsoe J, Rapaport M, Gillin JC. Affective state and EEG sleep profile in response to rapid tryptophan depletion in recently recovered nonmedicated depressed individuals. J Affect Disord. 2004 Dec; 83(2-3):253-62. PMID: 15555723.
        View in: PubMed
      53. Kelsoe J. Genomics and the Human Genome Project: implications for psychiatry. Int Rev Psychiatry. 2004 Nov; 16(4):294-300. PMID: 16194762.
        View in: PubMed
      54. Schulze TG, Buervenich S, Badner JA, Steele CJ, Detera-Wadleigh SD, Dick D, Foroud T, Cox NJ, MacKinnon DF, Potash JB, Berrettini WH, Byerley W, Coryell W, DePaulo JR, Gershon ES, Kelsoe J, McInnis MG, Murphy DL, Reich T, Scheftner W, Nurnberger JI, McMahon FJ. Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees. Biol Psychiatry. 2004 Jul 1; 56(1):18-23. PMID: 15219468.
        View in: PubMed
      55. Greenwood TA, Kelsoe J. Promoter and intronic variants affect the transcriptional regulation of the human dopamine transporter gene. Genomics. 2003 Nov; 82(5):511-20. PMID: 14559208.
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      56. Caligiuri MP, Gentili V, Eberson S, Kelsoe J, Rapaport M, Gillin JC. A quantitative neuromotor predictor of antidepressant non-response in patients with major depression. J Affect Disord. 2003 Nov; 77(2):135-41. PMID: 14607390.
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      57. Landolt HP, Kelsoe J, Rapaport MH, Gillin JC. Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep. J Sleep Res. 2003 Mar; 12(1):13-8. PMID: 12603782.
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      58. Kelsoe J. Arguments for the genetic basis of the bipolar spectrum. J Affect Disord. 2003 Jan; 73(1-2):183-97. PMID: 12507751.
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      59. Liang SG, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Kelsoe J. A linkage disequilibrium study of bipolar disorder and microsatellite markers on 22q13. Psychiatr Genet. 2002 Dec; 12(4):231-5. PMID: 12454528.
        View in: PubMed
      60. Evans L, Golshan S, Kelsoe J, Rapaport M, Resovsky K, Sutton L, Gillin JC. Effects of rapid tryptophan depletion on sleep electroencephalogram and mood in subjects with partially remitted depression on bupropion. Neuropsychopharmacology. 2002 Dec; 27(6):1016-26. PMID: 12464458.
        View in: PubMed
      61. Kelsoe J, Niculescu AB. Finding genes for bipolar disorder in the functional genomics era: from convergent functional genomics to phenomics and back. CNS Spectr. 2002 Mar; 7(3):215-6, 223-6. PMID: 15211285.
        View in: PubMed
      62. Shilling PD, Kelsoe J. Functional genomics approaches to understanding brain disorders. Pharmacogenomics. 2002 Jan; 3(1):31-45. PMID: 11966401.
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