Andrea Spadoni

Title(s)Associate Adjunct Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Overview 
    Collapse Overview
    The overall goal of my work is to understand neural mechanisms of psychopathology, in particular trauma and alcohol use disorders and their common comorbidities, and to utilize this understanding to improve diagnosis and treatments. My background is firmly rooted in understanding neural patterns that relate to the risk for and consequences of PTSD and alcohol use utilizing state-of-the-art neuroimaging techniques. I am highly involved in an active program of multimodal imaging research investigating the neurocognitive, neurofunctional, and structural correlates of psychopathology and its empirically supported treatments. For the past two decades I have provided clinical services for or conducted research with individuals with drug use disorders and or posttraumatic stress symptoms. During this time, I developed a deep commitment to this populations’ mental health and an invaluable perspective on their phenotypic presentation and clinical needs. My strong background in MRI research of alcohol use disorders, comorbid substance use and traumatic stress, proficiency in the theory and application of first line treatments these disorders, expertise in conducting interdisciplinary longitudinal neuroimaging work within the context of randomized controlled trials, and my role in the VASDHS Center for Excellence in Stress and Mental Health, positions me to make a lasting contribution to the field that translates neurobiological mechanisms into improved diagnosis and treatment.

    I am a member of the VA San Diego Institutional Review Board, and the VASDHS Center for Excellence in Stress and Mental Health (Neuroscience Unit) where I am Co-Chair of the Platform Strategies Workgroup - whose goal is to foster collaborations between researchers interested in integrating clinical trial and biological methodologies to understand treatment predictors and mechanisms in Veterans. I regularly serve as an ad-hoc member of the VA Mental Health and Behavioral Sciences-P (MHBP) review group.

    I am fully committed to training the next leaders in our field, as my service and teaching activities demonstrate. I am Co-Director of the NIAAA T32 “Alcohol Research in the Science/Practitioner Model,” and am also faculty on the VA Interprofessional and the VA San Diego Center for Stress and Mental Illness Fellowships, and am a member of the UCSD Psychiatry and Education Training Council, as well as the UCSD Graduate Programs Evaluation Committee.

    Collapse Research 
    Collapse Research Activities and Funding
    Neuromarkers of Treatment for Comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder
    NIH I01CX001762Oct 1, 2018 - Sep 30, 2022
    Role: Principal Investigator
    Neural Mechanisms of a Novel Psychotherapy in Veterans with PTSD and Alcoholism
    NIH IK2CX000864Oct 1, 2013 - Sep 30, 2018
    Role: Principal Investigator
    Functional Connectivity in Youth at Risk for Alcoholism
    NIH F31AA016727Sep 21, 2006 - Sep 20, 2008
    Role: Principal Investigator
    Alcohol Research in the Science/Practitioner Model
    NIH T32AA013525Aug 1, 2002 - Jul 31, 2022
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Learning from addiction: Craving of prescription opioids in chronic pain sufferers. Neurosci Biobehav Rev. 2022 11; 142:104904. Strigo IA, Murphy E, Mitchell JM, Spadoni AD. PMID: 36202255; PMCID: PMC10917419.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Contribution of early-life unpredictability to neuropsychiatric symptom patterns in adulthood. Depress Anxiety. 2022 10; 39(10-11):706-717. Spadoni AD, Vinograd M, Cuccurazzu B, Torres K, Glynn LM, Davis EP, Baram TZ, Baker DG, Nievergelt CM, Risbrough VB. PMID: 35833573; PMCID: PMC9881456.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    3. Understanding Pain and Trauma Symptoms in Veterans From Resting-State Connectivity: Unsupervised Modeling. Front Pain Res (Lausanne). 2022; 3:871961. Strigo IA, Spadoni AD, Simmons AN. PMID: 35620636; PMCID: PMC9127988.
      View in: PubMed   Mentions: 2  
    4. Effects of Noninvasive Cervical Vagal Nerve Stimulation on Cognitive Performance But Not Brain Activation in Healthy Adults. Neuromodulation. 2022 Apr; 25(3):424-432. Klaming R, Simmons AN, Spadoni AD, Lerman I. PMID: 35396072; PMCID: PMC8144242.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    5. Resting-state connectivity subtype of comorbid PTSD and alcohol use disorder moderates improvement from integrated prolonged exposure therapy in Veterans. Psychol Med. 2023 01; 53(2):332-341. Stout DM, Harlé KM, Norman SB, Simmons AN, Spadoni AD. PMID: 33926595; PMCID: PMC10880798.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    6. Higher affective congruency in the approach-avoidance task is associated with insular deactivation to dynamic facial expressions. Neuropsychologia. 2021 01 22; 151:107734. Harlé KM, Simmons AN, Bomyea J, Spadoni AD, Taylor CT. PMID: 33358774; PMCID: PMC7856231.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Effects of Noninvasive Cervical Vagal Nerve Stimulation on Cognitive Performance But Not Brain Activation in Healthy Adults. Neuromodulation. 2020 Nov 25. Klaming R, Simmons AN, Spadoni AD, Lerman I. PMID: 33236815; PMCID: PMC8144242.
      View in: PubMed   Mentions: 1     Fields:    
    8. Proactive engagement of cognitive control modulates implicit approach-avoidance bias. Cogn Affect Behav Neurosci. 2020 10; 20(5):998-1010. Harlé KM, Bomyea J, Spadoni AD, Simmons AN, Taylor CT. PMID: 32761312; PMCID: PMC8210886.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Neural affective mechanisms associated with treatment responsiveness in veterans with PTSD and comorbid alcohol use disorder. Psychiatry Res Neuroimaging. 2020 11 30; 305:111172. Harlé KM, Simmons AN, Norman SB, Spadoni AD. PMID: 32927371; PMCID: PMC8486287.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Neurocomputational Changes in Inhibitory Control Associated With Prolonged Exposure Therapy. J Trauma Stress. 2020 08; 33(4):500-510. Harlé KM, Spadoni AD, Norman SB, Simmons AN. PMID: 31765510; PMCID: PMC8567749.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Expansion of hippocampal and amygdala shape in posttraumatic stress and early life stress. Neuroimage Clin. 2019; 24:101982. Klaming R, Spadoni AD, Veltman DJ, Simmons AN. PMID: 31437724; PMCID: PMC6706650.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    12. Shared gray matter reductions across alcohol use disorder and posttraumatic stress disorder in the anterior cingulate cortex: A dual meta-analysis. Neurobiol Stress. 2019 Feb; 10:100132. Klaming R, Harlé KM, Infante MA, Bomyea J, Kim C, Spadoni AD. PMID: 30627600; PMCID: PMC6302237.
      View in: PubMed   Mentions: 11  
    13. Multimodal canonical correlation reveals converging neural circuitry across trauma-related disorders of affect and cognition. Neurobiol Stress. 2018 Nov; 9:241-250. Stout DM, Buchsbaum MS, Spadoni AD, Risbrough VB, Strigo IA, Matthews SC, Simmons AN. PMID: 30450388; PMCID: PMC6234282.
      View in: PubMed   Mentions: 10  
    14. Neural measures associated with configural threat acquisition. Neurobiol Learn Mem. 2018 04; 150:99-106. Stout DM, Glenn DE, Acheson DT, Spadoni AD, Risbrough VB, Simmons AN. PMID: 29544725.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    15. Emerging Approaches to Neurocircuits in PTSD and TBI: Imaging the Interplay of Neural and Emotional Trauma. Curr Top Behav Neurosci. 2018; 38:163-192. Spadoni AD, Huang M, Simmons AN. PMID: 29285732; PMCID: PMC8896198.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    16. Repeated Exposure to Experimental Pain Differentiates Combat Traumatic Brain Injury with and without Post-Traumatic Stress Disorder. J Neurotrauma. 2018 01 15; 35(2):297-307. Strigo IA, Spadoni AD, Inslicht SS, Simmons AN. PMID: 28931334.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Neural mechanisms of interference control in working memory capacity. Hum Brain Mapp. 2018 02; 39(2):772-782. Bomyea J, Taylor CT, Spadoni AD, Simmons AN. PMID: 29139174; PMCID: PMC6866570.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    18. Faking bad: The neural correlates of feigning memory impairment. Neuropsychology. 2016 Mar; 30(3):377-84. Kosheleva E, Spadoni AD, Strigo IA, Buchsbaum MS, Simmons AN. PMID: 26765340.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Neural correlates of malingering in mild traumatic brain injury: A positron emission tomography study. Psychiatry Res. 2015 Sep 30; 233(3):367-72. Spadoni AD, Kosheleva E, Buchsbaum MS, Simmons AN. PMID: 26184458.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. Maximizing the utility of a single site randomized controlled psychotherapy trial. Contemp Clin Trials. 2015 May; 42:244-51. Norman SB, Haller M, Spadoni AD, Drummond SP, Risbrough V, Hamblen JL, Trim RS, Blanes EX. PMID: 25933919; PMCID: PMC8876249.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    21. Whole brain expression of bipolar disorder associated genes: structural and genetic analyses. PLoS One. 2014; 9(6):e100204. McCarthy MJ, Liang S, Spadoni AD, Kelsoe JR, Simmons AN. PMID: 24941232; PMCID: PMC4062532.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    22. Family history of alcohol use disorders and neuromaturation: a functional connectivity study with adolescents. Am J Drug Alcohol Abuse. 2013 Nov; 39(6):356-64. Spadoni AD, Simmons AN, Yang TT, Tapert SF. PMID: 24200205; PMCID: PMC3959877.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    23. Neurosubstrates of remission following prolonged exposure therapy in veterans with posttraumatic stress disorder. Psychother Psychosom. 2013; 82(6):382-9. Simmons AN, Norman SB, Spadoni AD, Strigo IA. PMID: 24061484.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    24. Diffusion tensor imaging evidence of white matter disruption associated with loss versus alteration of consciousness in warfighters exposed to combat in Operations Enduring and Iraqi Freedom. Psychiatry Res. 2012 Nov 30; 204(2-3):149-54. Matthews SC, Spadoni AD, Lohr JB, Strigo IA, Simmons AN. PMID: 23149025; PMCID: PMC3866101.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    25. A functional magnetic resonance imaging study of spatial working memory in children with prenatal alcohol exposure: contribution of familial history of alcohol use disorders. Alcohol Clin Exp Res. 2013 Jan; 37(1):132-40. Norman AL, O'Brien JW, Spadoni AD, Tapert SF, Jones KL, Riley EP, Mattson SN. PMID: 23072431; PMCID: PMC3694801.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    26. The parametric, psychological, neuropsychological, and neuroanatomical properties of self and world evaluation. PLoS One. 2012; 7(2):e31509. Simmons AN, Thayer RE, Spadoni AD, Matthews SC, Strigo IA, Tapert SF. PMID: 22348093; PMCID: PMC3278451.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Neural activation during inhibition predicts initiation of substance use in adolescence. Drug Alcohol Depend. 2011 Dec 15; 119(3):216-23. Norman AL, Pulido C, Squeglia LM, Spadoni AD, Paulus MP, Tapert SF. PMID: 21782354; PMCID: PMC3208054.
      View in: PubMed   Mentions: 140     Fields:    Translation:Humans
    28. Craving in response to stress induction in a human laboratory paradigm predicts treatment outcome in alcohol-dependent individuals. Psychopharmacology (Berl). 2011 Nov; 218(1):121-9. Higley AE, Crane NA, Spadoni AD, Quello SB, Goodell V, Mason BJ. PMID: 21607563; PMCID: PMC3191263.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    29. Hippocampal volumes in adolescents with and without a family history of alcoholism. Am J Drug Alcohol Abuse. 2010 May; 36(3):161-7. Hanson KL, Medina KL, Nagel BJ, Spadoni AD, Gorlick A, Tapert SF. PMID: 20465374; PMCID: PMC3891832.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    30. Initiating moderate to heavy alcohol use predicts changes in neuropsychological functioning for adolescent girls and boys. Psychol Addict Behav. 2009 Dec; 23(4):715-22. Squeglia LM, Spadoni AD, Infante MA, Myers MG, Tapert SF. PMID: 20025379; PMCID: PMC2802333.
      View in: PubMed   Mentions: 137     Fields:    Translation:Humans
    31. BOLD response during spatial working memory in youth with heavy prenatal alcohol exposure. Alcohol Clin Exp Res. 2009 Dec; 33(12):2067-76. Spadoni AD, Bazinet AD, Fryer SL, Tapert SF, Mattson SN, Riley EP. PMID: 19740135; PMCID: PMC2789890.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    32. Characterization of white matter microstructure in fetal alcohol spectrum disorders. Alcohol Clin Exp Res. 2009 Mar; 33(3):514-21. Fryer SL, Schweinsburg BC, Bjorkquist OA, Frank LR, Mattson SN, Spadoni AD, Riley EP. PMID: 19120066; PMCID: PMC2651988.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    33. Effects of family history of alcohol use disorders on spatial working memory BOLD response in adolescents. Alcohol Clin Exp Res. 2008 Jul; 32(7):1135-45. Spadoni AD, Norman AL, Schweinsburg AD, Tapert SF. PMID: 18540914; PMCID: PMC2532854.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    34. Microstructural integrity of the corpus callosum linked with neuropsychological performance in adolescents. Brain Cogn. 2008 Jul; 67(2):225-33. Fryer SL, Frank LR, Spadoni AD, Theilmann RJ, Nagel BJ, Schweinsburg AD, Tapert SF. PMID: 18346830; PMCID: PMC2491343.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    35. Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control. Alcohol Clin Exp Res. 2007 Aug; 31(8):1415-24. Fryer SL, Tapert SF, Mattson SN, Paulus MP, Spadoni AD, Riley EP. PMID: 17559542.
      View in: PubMed   Mentions: 77     Fields:    Translation:Humans
    36. Neuroimaging and fetal alcohol spectrum disorders. Neurosci Biobehav Rev. 2007; 31(2):239-45. Spadoni AD, McGee CL, Fryer SL, Riley EP. PMID: 17097730; PMCID: PMC1820628.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
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