Daniel Kripke

Title(s)Senate Emeritus, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Biography

    Educated at Harvard College, P&S, the US Air Force 6571st Aeromedical Research Lab and an Albert Einstein residency, Dr. Kripke has spent over 30 years at UCSD. He developed the first sleep clinic in the region and new technologies for home sleep monitoring and wrist actigraphy. He did the first controlled trial of bright light treatment at the San Diego VA Medical Center in 1981. He has been concerned with the community prevalence of sleep apnea, particularly with aging, and the excess mortality associated with sleep >= 8 hours and with sleeping pills. With development of the Circadian Pacemaker Laboratory in the Sam and Rose Stein Clinical Research Building, they have been doing studies in basic and applied human chronobiology with a view towards understanding affective disorders.

    Research Interests

    Current studies focus on bright light treatment of depression, the clinical efficacy and the underlying mechanisms. They are also interested in the circadian phase-response to bright light and exercise stimuli and the consequences for melatonin regulation. Light’s roll in photoperiodic regulation in humans is a long-term theme. Preliminary studies are examining how genetic variations in circadian clocks may influence clinical pathology.

    Collapse Research 
    Collapse Research Activities and Funding
    Light Stimulation of Luteinizing Hormone
    NIH R01MH068545Sep 1, 2004 - Aug 31, 2008
    Role: Principal Investigator
    GENETIC VARIANTS IN CIRCADIAN RHYTHM SLEEP DISORDERS
    NIH R01HL071123Apr 1, 2004 - Jun 30, 2007
    Role: Principal Investigator
    GENETIC VARIANTS IN CIRCADIAN RHYTHM SLEEP DISORDERS
    NIH R56HL071123Jul 1, 2002 - Jun 30, 2009
    Role: Principal Investigator
    PHASE RESPONSE CURVES FOR EXERCISE AND BRIGHT LIGHT
    NIH R01HL061280Aug 1, 1999 - Jul 31, 2004
    Role: Principal Investigator
    VERIFICATION OF CIRCADIAN ABNORMALITIES IN AGING
    NIH R01AG015763Sep 1, 1998 - Aug 31, 2004
    Role: Principal Investigator
    EMF EFFECTS ON MELATONIN AMONG AGING VOLUNTEERS
    NIH R03ES008930Jan 15, 1997 - Jun 30, 1999
    Role: Principal Investigator
    VALIDATION AND EXPLORATION OF SLEEP AND MOOD PREDICTORS
    NIH R01HL055983Aug 1, 1995 - Jul 31, 2000
    Role: Principal Investigator
    ILLUMINATION IN HUMAN AGING: SLEEP AND MOOD EFFECTS
    NIH R01AG012364Sep 30, 1994 - Apr 30, 2006
    Role: Principal Investigator
    BEHAVIORAL/LIGHT EFFECTS ON MENSTRUAL CYCLE REGULATION
    NIH R03MH051820May 1, 1994 - Apr 30, 1997
    Role: Principal Investigator
    AGE RELATED PREVALENCE OF SLEEP RESPIRATORY DISTURBANCES
    NIH R01HL040930Apr 1, 1990 - Mar 31, 1996
    Role: Principal Investigator
    PHOTOPERIODIC TREATMENT OF DEPRESSION
    NIH R01MH038822Mar 1, 1984 - Jun 30, 1988
    Role: Principal Investigator
    PREVALENCE OF SLEEP APNEA IN AN AGED POPULATION
    NIH R01AG002711Apr 1, 1981 - Mar 31, 2001
    Role: Co-Principal Investigator
    BIO-OSCILLATOR EFFECTS ON MENTAL FUNCTION
    NIH K05MH000117Jan 1, 1977 - Dec 31, 1996
    Role: Principal Investigator
    BIO-OSCILLATOR EFFECTS ON MENTAL FUNCTION
    NIH K02MH000117Jan 1, 1977 - Dec 31, 1986
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Human circadian phase-response curves for exercise. J Physiol. 2019 04; 597(8):2253-2268. Youngstedt SD, Elliott JA, Kripke DF. PMID: 30784068.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    2. Early versus late wake therapy improves mood more in antepartum versus postpartum depression by differentially altering melatonin-sleep timing disturbances. J Affect Disord. 2019 02 15; 245:608-616. Parry BL, Meliska CJ, Lopez AM, Sorenson DL, Martinez LF, Orff HJ, Hauger RL, Kripke DF. PMID: 30445386.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. What do hypnotics cost hospitals and healthcare? F1000Res. 2017; 6:542. Kripke DF. PMID: 28781755.
      View in: PubMed   Mentions:    Fields:    
    4. Advanced Circadian Phase in Mania and Delayed Circadian Phase in Mixed Mania and Depression Returned to Normal after Treatment of Bipolar Disorder. EBioMedicine. 2016 Sep; 11:285-295. Moon JH, Cho CH, Son GH, Geum D, Chung S, Kim H, Kang SG, Park YM, Yoon HK, Kim L, Jee HJ, An H, Kripke DF, Lee HJ. PMID: 27543154.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    5. Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit. F1000Res. 2016; 5:918. Kripke DF. PMID: 27303633.
      View in: PubMed   Mentions: 22     Fields:    
    6. When our body clocks run late: does it make us depressed? Ann Transl Med. 2016 May; 4(9):178. Kripke DF. PMID: 27275491.
      View in: PubMed   Mentions:
    7. Mortality Risk of Hypnotics: Strengths and Limits of Evidence. Drug Saf. 2016 Feb; 39(2):93-107. Kripke DF. PMID: 26563222.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    8. I petitioned the FDA to restrict hypnotics: here is why. Sleep Med. 2016 07; 23:119-120. Kripke DF. PMID: 26924532.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Has adult sleep duration declined over the last 50+ years? Sleep Med Rev. 2016 08; 28:69-85. Youngstedt SD, Goff EE, Reynolds AM, Kripke DF, Irwin MR, Bootzin RR, Khan N, Jean-Louis G. PMID: 26478985.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    10. Is suvorexant a better choice than alternative hypnotics? F1000Res. 2015; 4:456. Kripke DF. PMID: 26594338.
      View in: PubMed   Mentions: 4     Fields:    
    11. Type III home sleep testing versus pulse oximetry: is the respiratory disturbance index better than the oxygen desaturation index to predict the apnoea-hypopnoea index measured during laboratory polysomnography? BMJ Open. 2015 Jun 30; 5(6):e007956. Dawson A, Loving RT, Gordon RM, Abel SL, Loewy D, Kripke DF, Kline LE. PMID: 26129636.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    12. Do hypnotic drugs cause cancer, like cigarettes? Sleep Med. 2015 Dec; 16(12):1550-1. Kripke DF. PMID: 26210392.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Photoperiodic and circadian bifurcation theories of depression and mania. F1000Res. 2015; 4:107. Kripke DF, Elliott JA, Welsh DK, Youngstedt SD. PMID: 26180634.
      View in: PubMed   Mentions: 10     Fields:    
    14. A breakthrough treatment for major depression. J Clin Psychiatry. 2015 May; 76(5):e660-1. Kripke DF. PMID: 26035202.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Wake up time, light, and mood in a population sample age 40-64 years. Psychiatry Investig. 2015 Apr; 12(2):177-82. Endo T, Kripke DF, Ancoli-Israel S. PMID: 25866517.
      View in: PubMed   Mentions:
    16. Genetic variants associated with sleep disorders. Sleep Med. 2015 Feb; 16(2):217-24. Kripke DF, Kline LE, Nievergelt CM, Murray SS, Shadan FF, Dawson A, Poceta JS, Cronin J, Jamil SM, Tranah GJ, Loving RT, Grizas AP, Hahn EK. PMID: 25660813.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    17. Circadian polymorphisms in night owls, in bipolars, and in non-24-hour sleep cycles. Psychiatry Investig. 2014 Oct; 11(4):345-62. Kripke DF, Klimecki WT, Nievergelt CM, Rex KM, Murray SS, Shekhtman T, Tranah GJ, Loving RT, Lee HJ, Rhee MK, Shadan FF, Poceta JS, Jamil SM, Kline LE, Kelsoe JR. PMID: 25395965.
      View in: PubMed   Mentions:
    18. "Rebound" is not an appropriate criterion for withdrawal insomnia. Sleep Med. 2014 Dec; 15(12):1594. Kripke DF. PMID: 25441753.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Hypnotics cause insomnia: evidence from clinical trials. Sleep Med. 2014 Sep; 15(9):1168-9. Kripke DF. PMID: 25152199.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. Evidence for harm, comment on ‘Use of benzodiazepines or benzodiazepine related drugs and the risk of cancer: a population-based case-control study’. Br J Clin Pharmacol. 2014 Jul; 78(1):186-7. Kripke DF, Langer RD. PMID: 25083532.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Antepartum depression severity is increased during seasonally longer nights: relationship to melatonin and cortisol timing and quantity. Chronobiol Int. 2013 Nov; 30(9):1160-73. Meliska CJ, Martínez LF, López AM, Sorenson DL, Nowakowski S, Kripke DF, Elliott J, Parry BL. PMID: 23998286.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    22. Surprising view of insomnia and sleeping pills. Sleep. 2013 Aug 01; 36(8):1127-8. Kripke DF. PMID: 23904671.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Chronic moderate sleep restriction in older long sleepers and older average duration sleepers: a randomized controlled trial. Contemp Clin Trials. 2013 Sep; 36(1):175-86. Youngstedt SD, Jean-Louis G, Bootzin RR, Kripke DF, Cooper J, Dean LR, Catao F, James S, Vining C, Williams NJ, Irwin MR. PMID: 23811325.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. FMR1, circadian genes and depression: suggestive associations or false discovery? J Circadian Rhythms. 2013 Mar 23; 11(1):3. Kripke DF, Nievergelt CM, Tranah GJ, Murray SS, Rex KM, Grizas AP, Hahn EK, Lee HJ, Kelsoe JR, Kline LE. PMID: 23521777.
      View in: PubMed   Mentions:
    25. Insomnia: More trials needed to assess sleeping pills. Nature. 2013 Jan 17; 493(7432):305. Moser M, Kripke DF. PMID: 23325202.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Evaluation of two circadian rhythm questionnaires for screening for the delayed sleep phase disorder. Psychiatry Investig. 2012 Sep; 9(3):236-44. Rhee MK, Lee HJ, Rex KM, Kripke DF. PMID: 22993522.
      View in: PubMed   Mentions:
    27. A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder. J Affect Disord. 2013 Feb 20; 145(2):200-7. Lee HJ, Woo HG, Greenwood TA, Kripke DF, Kelsoe JR. PMID: 22925353.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    28. Do no harm: not even to some degree. J Clin Sleep Med. 2012 Aug 15; 8(4):353-4. Kripke DF, Langer RD, Kline LE. PMID: 22893763.
      View in: PubMed   Mentions: 3     Fields:    
    29. Hypnotics' association with mortality or cancer: a matched cohort study. BMJ Open. 2012; 2(1):e000850. Kripke DF, Langer RD, Kline LE. PMID: 22371848.
      View in: PubMed   Mentions: 108     Fields:    
    30. Short wavelength light administered just prior to waking: a pilot study. Biol Rhythm Res. 2013 Jan 01; 44(1):13-32. Grandner MA, Kripke DF, Elliott J, Cole R. PMID: 23275686.
      View in: PubMed   Mentions: 1     Fields:    
    31. Polymorphisms in melatonin synthesis pathways: possible influences on depression. J Circadian Rhythms. 2011 Aug 09; 9:8. Kripke DF, Nievergelt CM, Tranah GJ, Murray SS, McCarthy MJ, Rex KM, Parimi N, Kelsoe JR. PMID: 21827647.
      View in: PubMed   Mentions:
    32. Bright light treatment reduces symptoms in older adults with non-seasonal major depression. Evid Based Ment Health. 2011 Aug; 14(3):75. Kripke DF. PMID: 21764874.
      View in: PubMed   Mentions: 1     Fields:    
    33. Delayed sleep phase syndrome is related to seasonal affective disorder. J Affect Disord. 2011 Oct; 133(3):573-9. Lee HJ, Rex KM, Nievergelt CM, Kelsoe JR, Kripke DF. PMID: 21601293.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    34. Is insomnia associated with mortality? Sleep. 2011 May 01; 34(5):555; author reply 557-8. Kripke DF. PMID: 21532944.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. Wrist actigraphic scoring for sleep laboratory patients: algorithm development. J Sleep Res. 2010 Dec; 19(4):612-9. Kripke DF, Hahn EK, Grizas AP, Wadiak KH, Loving RT, Poceta JS, Shadan FF, Cronin JW, Kline LE. PMID: 20408923.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    36. Illumination and mood. Psychopharmacology (Berl). 2011 Feb; 213(4):833. Kripke D. PMID: 20953587.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. PER2 variation is associated with diurnal preference in a Korean young population. Behav Genet. 2011 Mar; 41(2):273-7. Lee HJ, Kim L, Kang SG, Yoon HK, Choi JE, Park YM, Kim SJ, Kripke DF. PMID: 20931356.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    38. Mortality related to actigraphic long and short sleep. Sleep Med. 2011 Jan; 12(1):28-33. Kripke DF, Langer RD, Elliott JA, Klauber MR, Rex KM. PMID: 20870457.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    39. Weak evidence of bright light effects on human LH and FSH. J Circadian Rhythms. 2010 May 11; 8:5. Kripke DF, Elliott JA, Youngstedt SD, Parry BL, Hauger RL, Rex KM. PMID: 20459826.
      View in: PubMed   Mentions:
    40. Lack of impairment in glucose tolerance: support for further investigation of sleep restriction in older long sleepers. J Sleep Res. 2010 Mar; 19(1 Pt 1):116-7. Youngstedt SD, Kripke DF, Kline CE, Zielinski MR, Bogan RK. PMID: 20470263.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    41. Genotyping sleep disorders patients. Psychiatry Investig. 2010 Mar; 7(1):36-42. Kripke DF, Shadan FF, Dawson A, Cronin JW, Jamil SM, Grizas AP, Koziol JA, Kline LE. PMID: 20396431.
      View in: PubMed   Mentions:
    42. Self-reported long sleep in older adults is closely related to objective time in bed. Sleep Biol Rhythms. 2010 Jan; 8(1):42-51. Kline CE, Zielinski MR, Devlin TM, Kripke DF, Bogan RK, Youngstedt SD. PMID: 25210491.
      View in: PubMed   Mentions:
    43. Relationships among dietary nutrients and subjective sleep, objective sleep, and napping in women. Sleep Med. 2010 Feb; 11(2):180-4. Grandner MA, Kripke DF, Naidoo N, Langer RD. PMID: 20005774.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimals
    44. Tolerance of chronic 90-minute time-in-bed restriction in older long sleepers. Sleep. 2009 Nov; 32(11):1467-79. Youngstedt SD, Kline CE, Zielinski MR, Kripke DF, Devlin TM, Bogan RK, Wilcox S, Hardin JW. PMID: 19928386.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    45. Meta-analyses of hypnotics and infections: eszopiclone, ramelteon, zaleplon, and zolpidem. J Clin Sleep Med. 2009 Aug 15; 5(4):377-83. Joya FL, Kripke DF, Loving RT, Dawson A, Kline LE. PMID: 19968019.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    46. Accentuation of suicides but not homicides with rising latitudes of Greenland in the sunny months. BMC Psychiatry. 2009 May 08; 9:20. Björkstén KS, Kripke DF, Bjerregaard P. PMID: 19422728.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansPHPublic Health
    47. Do hypnotics cause death and cancer? The burden of proof. Sleep Med. 2009 Mar; 10(3):275-6. Kripke DF. PMID: 19269891.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    48. Circadian polymorphisms associated with affective disorders. J Circadian Rhythms. 2009 Jan 23; 7:2. Kripke DF, Nievergelt CM, Joo E, Shekhtman T, Kelsoe JR. PMID: 19166596.
      View in: PubMed   Mentions:
    49. Evaluation of immobility time for sleep latency in actigraphy. Sleep Med. 2009 Jun; 10(6):621-5. Chae KY, Kripke DF, Poceta JS, Shadan F, Jamil SM, Cronin JW, Kline LE. PMID: 19103508.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    50. CPAP therapy of obstructive sleep apnea in type 2 diabetics improves glycemic control during sleep. J Clin Sleep Med. 2008 Dec 15; 4(6):538-42. Dawson A, Abel SL, Loving RT, Dailey G, Shadan FF, Cronin JW, Kripke DF, Kline LE. PMID: 19110882.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    51. Plasma melatonin circadian rhythm disturbances during pregnancy and postpartum in depressed women and women with personal or family histories of depression. Am J Psychiatry. 2008 Dec; 165(12):1551-8. Parry BL, Meliska CJ, Sorenson DL, Lopez AM, Martinez LF, Nowakowski S, Elliott JA, Hauger RL, Kripke DF. PMID: 18829869.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    52. Possibility that certain hypnotics might cause cancer in skin. J Sleep Res. 2008 Sep; 17(3):245-50. Kripke DF. PMID: 18844818.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    53. No effect of 8-week time in bed restriction on glucose tolerance in older long sleepers. J Sleep Res. 2008 Dec; 17(4):412-9. Zielinski MR, Kline CE, Kripke DF, Bogan RK, Youngstedt SD. PMID: 18691360.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansPHPublic Health
    54. Delayed sleep phase cases and controls. J Circadian Rhythms. 2008 Apr 29; 6:6. Kripke DF, Rex KM, Ancoli-Israel S, Nievergelt CM, Klimecki W, Kelsoe JR. PMID: 18445295.
      View in: PubMed   Mentions:
    55. Circadian rhythm of CSF monoamines and hypocretin-1 in restless legs syndrome and Parkinson's disease. Sleep Med. 2009 Jan; 10(1):129-33. Poceta JS, Parsons L, Engelland S, Kripke DF. PMID: 18207455.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    56. Who should sponsor sleep disorders pharmaceutical trials? J Clin Sleep Med. 2007 Dec 15; 3(7):671-3. Kripke DF. PMID: 18198797.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    57. Self-reported sleep latency in postmenopausal women. J Korean Med Sci. 2007 Dec; 22(6):1007-14. Park DH, Kripke DF, Louis GJ, Elliott JA, Klauber MR, Rex KM, Tuunainen A, Langer RD. PMID: 18162715.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    58. Does bright light have an anxiolytic effect? - an open trial. BMC Psychiatry. 2007 Oct 30; 7:62. Youngstedt SD, Kripke DF. PMID: 17971237.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    59. Greater incidence of depression with hypnotic use than with placebo. BMC Psychiatry. 2007 Aug 21; 7:42. Kripke DF. PMID: 17711589.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    60. Circadian phase response curves to light in older and young women and men. J Circadian Rhythms. 2007 Jul 10; 5:4. Kripke DF, Elliott JA, Youngstedt SD, Rex KM. PMID: 17623102.
      View in: PubMed   Mentions:
    61. More prominent reactivity in mood than activity and sleep induced by differential light exposure due to seasonal and local differences. Chronobiol Int. 2007; 24(5):905-20. Park DH, Kripke DF, Cole RJ. PMID: 17994345.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    62. Effect of laser trabeculoplasty on nocturnal intraocular pressure in medically treated glaucoma patients. Ophthalmology. 2007 Apr; 114(4):666-70. Lee AC, Mosaed S, Weinreb RN, Kripke DF, Liu JH. PMID: 17188360.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    63. Criterion validity of the Pittsburgh Sleep Quality Index: Investigation in a non-clinical sample. Sleep Biol Rhythms. 2006 Jun; 4(2):129-139. Grandner MA, Kripke DF, Yoon IY, Youngstedt SD. PMID: 22822303.
      View in: PubMed   Mentions:
    64. Sustained effect of travoprost on diurnal and nocturnal intraocular pressure. Am J Ophthalmol. 2006 Jun; 141(6):1131-3. Sit AJ, Weinreb RN, Crowston JG, Kripke DF, Liu JH. PMID: 16765686.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    65. Light exposure is related to social and emotional functioning and to quality of life in older women. Psychiatry Res. 2006 Jun 30; 143(1):35-42. Grandner MA, Kripke DF, Langer RD. PMID: 16725207.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    66. Melatonin effects on luteinizing hormone in postmenopausal women: a pilot clinical trial NCT00288262. BMC Womens Health. 2006 May 16; 6:8. Kripke DF, Kline LE, Shadan FF, Dawson A, Poceta JS, Elliott JA. PMID: 16704731.
      View in: PubMed   Mentions: 4     Fields:    
    67. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. . 2006 Apr 05; 141B(3):234-41. Nievergelt CM, Kripke DF, Barrett TB, Burg E, Remick RA, Sadovnick AD, McElroy SL, Keck PE, Schork NJ, Kelsoe JR. PMID: 16528748.
      View in: PubMed   Mentions:
    68. Benefits of light treatment for depression. Am J Psychiatry. 2006 Jan; 163(1):162-3; author reply 163. Kripke DF, Tuunainen A, Endo T. PMID: 16390913.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    69. Daily illumination exposure and melatonin: influence of ophthalmic dysfunction and sleep duration. J Circadian Rhythms. 2005 Dec 01; 3:13. Jean-Louis G, Kripke DF, Elliott JA, Zizi F, Wolintz AH, Lazzaro DR. PMID: 16321164.
      View in: PubMed   Mentions:
    70. Bright green light treatment of depression for older adults [ISRCTN69400161]. BMC Psychiatry. 2005 Nov 09; 5:42. Loving RT, Kripke DF, Knickerbocker NC, Grandner MA. PMID: 16283926.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    71. Bright light treatment of depression for older adults [ISRCTN55452501]. BMC Psychiatry. 2005 Nov 09; 5:41. Loving RT, Kripke DF, Elliott JA, Knickerbocker NC, Grandner MA. PMID: 16283925.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    72. Circadian phase-shifting effects of a laboratory environment: a clinical trial with bright and dim light. J Circadian Rhythms. 2005 Sep 09; 3:11. Youngstedt SD, Kripke DF, Elliott JA, Rex KM. PMID: 16153301.
      View in: PubMed   Mentions:
    73. Selective publication. Sleep. 2005 Mar; 28(3):370; author reply 371-2. Kripke DF. PMID: 16173660.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    74. Examination of the clock gene Cryptochrome 1 in bipolar disorder: mutational analysis and absence of evidence for linkage or association. Psychiatr Genet. 2005 Mar; 15(1):45-52. Nievergelt CM, Kripke DF, Remick RA, Sadovnick AD, McElroy SL, Keck PE, Kelsoe JR. PMID: 15722957.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    75. Suicides in the midnight sun--a study of seasonality in suicides in West Greenland. Psychiatry Res. 2005 Feb 28; 133(2-3):205-13. Björkstén KS, Bjerregaard P, Kripke DF. PMID: 15740996.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    76. Circadian phase in adults of contrasting ages. Chronobiol Int. 2005; 22(4):695-709. Kripke DF, Youngstedt SD, Elliott JA, Tuunainen A, Rex KM, Hauger RL, Marler MR. PMID: 16147900.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    77. Association of morning illumination and window covering with mood and sleep among post-menopausal women. Sleep Biol Rhythms. 2004 Oct; 2(3):174-183. Youngstedt SD, Leung A, Kripke DF, Langer RD. PMID: 25374475.
      View in: PubMed   Mentions:
    78. Comparison of the nocturnal effects of once-daily timolol and latanoprost on intraocular pressure. Am J Ophthalmol. 2004 Sep; 138(3):389-95. Liu JH, Kripke DF, Weinreb RN. PMID: 15364220.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCTClinical Trials
    79. Naps and circadian rhythms in postmenopausal women. J Gerontol A Biol Sci Med Sci. 2004 Aug; 59(8):844-8. Yoon IY, Kripke DF, Elliott JA, Langer RD. PMID: 15345736.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    80. Long sleep and mortality: rationale for sleep restriction. Sleep Med Rev. 2004 Jun; 8(3):159-74. Youngstedt SD, Kripke DF. PMID: 15144959.
      View in: PubMed   Mentions: 109     Fields:    Translation:Humans
    81. Ethnicity, sleep, mood, and illumination in postmenopausal women. BMC Psychiatry. 2004 Apr 07; 4:8. Kripke DF, Jean-Louis G, Elliott JA, Klauber MR, Rex KM, Tuunainen A, Langer RD. PMID: 15070419.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    82. Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol. 2004 Mar; 55(3):335-46. Gorno-Tempini ML, Dronkers NF, Rankin KP, Ogar JM, Phengrasamy L, Rosen HJ, Johnson JK, Weiner MW, Miller BL. PMID: 14998231.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    83. Self-reported sleep complaints with long and short sleep: a nationally representative sample. Psychosom Med. 2004 Mar-Apr; 66(2):239-41. Grandner MA, Kripke DF. PMID: 15039509.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    84. Brightening depression. Science. 2004 Jan 23; 303(5657):467-9. Wirz-Justice A, Terman M, Oren DA, Goodwin FK, Kripke DF, Whybrow PC, Wisner KL, Wu JC, Lam RW, Berger M, Danilenko KV, Kasper S, Smeraldi E, Takahashi K, Thompson C, van den Hoofdakker RH. PMID: 14739440.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    85. Menopause: neuroendocrine changes and hormone replacement therapy. J Am Med Womens Assoc (1972). 2004; 59(2):135-45. Parry BL, Meliska CJ, Martinez LF, Basavaraj N, Zirpoli GG, Sorenson D, Maurer EL, Lopez A, Markova K, Gamst A, Wolfson T, Hauger R, Kripke DF. PMID: 15134429.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    86. PRC bisection tests. Chronobiol Int. 2003 Nov; 20(6):1117-23. Kripke DF, Clopton P, Marler MR, Youngstedt SD, Elliott JA. PMID: 14680147.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    87. Nocturnal elevation of intraocular pressure is detectable in the sitting position. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4439-42. Liu JH, Bouligny RP, Kripke DF, Weinreb RN. PMID: 14507890.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    88. Laboratory assessment of diurnal and nocturnal ocular perfusion pressures in humans. J Ocul Pharmacol Ther. 2003 Aug; 19(4):291-7. Liu JH, Gokhale PA, Loving RT, Kripke DF, Weinreb RN. PMID: 12964954.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    89. Age-related changes of circadian rhythms and sleep-wake cycles. J Am Geriatr Soc. 2003 Aug; 51(8):1085-91. Yoon IY, Kripke DF, Elliott JA, Youngstedt SD, Rex KM, Hauger RL. PMID: 12890070.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    90. Actigraphy suggests age-related differences in napping and nocturnal sleep. J Sleep Res. 2003 Jun; 12(2):87-93. Yoon IY, Kripke DF, Youngstedt SD, Elliott JA. PMID: 12753345.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    91. Reliability and validity of the Women's Health Initiative Insomnia Rating Scale. Psychol Assess. 2003 Jun; 15(2):137-48. Levine DW, Kripke DF, Kaplan RM, Lewis MA, Naughton MJ, Bowen DJ, Shumaker SA. PMID: 12847774.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansPHPublic Health
    92. Factor structure and measurement invariance of the Women's Health Initiative Insomnia Rating Scale. Psychol Assess. 2003 Jun; 15(2):123-36. Levine DW, Kaplan RM, Kripke DF, Bowen DJ, Naughton MJ, Shumaker SA. PMID: 12847773.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansPHPublic Health
    93. Measurement of illumination exposure in postpartum women. BMC Psychiatry. 2003 May 13; 3:5. Wang EJ, Kripke DF, Stein MT, Parry BL. PMID: 12744724.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    94. Melatonin excretion with affect disorders over age 60. Psychiatry Res. 2003 May 01; 118(1):47-54. Kripke DF, Youngstedt SD, Rex KM, Klauber MR, Elliott JA. PMID: 12759161.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    95. Luteinizing hormone following light exposure in healthy young men. Neurosci Lett. 2003 Apr 24; 341(1):25-8. Yoon IY, Kripke DF, Elliott JA, Youngstedt SD. PMID: 12676335.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    96. Twenty-four-hour intraocular pressure pattern associated with early glaucomatous changes. Invest Ophthalmol Vis Sci. 2003 Apr; 44(4):1586-90. Liu JH, Zhang X, Kripke DF, Weinreb RN. PMID: 12657596.
      View in: PubMed   Mentions: 88     Fields:    Translation:Humans
    97. Ineffectiveness of intermittent zolpidem. Sleep Med Rev. 2003 Apr; 7(2):193; author reply 195-6. Kripke DF. PMID: 12628218.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    98. No association of sleep with total daily physical activity in normal sleepers. Physiol Behav. 2003 Mar; 78(3):395-401. Youngstedt SD, Perlis ML, O'Brien PM, Palmer CR, Smith MT, Orff HJ, Kripke DF. PMID: 12676274.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    99. Polysomnographic sleep state from wrist activity. Sleep. 2003 Feb 01; 26(1):13; author reply 13. Kripke DF. PMID: 12627726.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    100. Sleep and mortality. Psychosom Med. 2003 Jan-Feb; 65(1):74. Kripke DF. PMID: 12554817.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    101. Efficacy of enhanced evening light for advanced sleep phase syndrome. Behav Sleep Med. 2003; 1(4):213-26. Palmer CR, Kripke DF, Savage HC, Cindrich LA, Loving RT, Elliott JA. PMID: 15602801.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    102. Illumination of upper and middle visual fields produces equivalent suppression of melatonin in older volunteers. Chronobiol Int. 2002 Sep; 19(5):883-91. Smith JS, Kripke DF, Elliott JA, Youngstedt SD. PMID: 12405551.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    103. No association of 6-sulfatoxymelatonin with in-bed 60-Hz magnetic field exposure or illumination level among older adults. Environ Res. 2002 Jul; 89(3):201-9. Youngstedt SD, Kripke DF, Elliott JA, Assmus JD. PMID: 12176004.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    104. Twenty-four-hour pattern of intraocular pressure in young adults with moderate to severe myopia. Invest Ophthalmol Vis Sci. 2002 Jul; 43(7):2351-5. Liu JH, Kripke DF, Twa MD, Gokhale PA, Jones EI, Park EH, Meehan JE, Weinreb RN. PMID: 12091437.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    105. Long-term follow-up of periodic limb movements in sleep in older adults. Sleep. 2002 May 01; 25(3):340-3. Gehrman P, Stepnowsky C, Cohen-Zion M, Marler M, Kripke DF, Ancoli-Israel S. PMID: 12003165.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    106. Depression and endogenous melatonin in postmenopausal women. J Affect Disord. 2002 May; 69(1-3):149-58. Tuunainen A, Kripke DF, Elliott JA, Assmus JD, Rex KM, Klauber MR, Langer RD. PMID: 12103461.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    107. Evening light exposure: implications for sleep and depression. J Am Geriatr Soc. 2002 Apr; 50(4):738-9. Wallace-Guy GM, Kripke DF, Jean-Louis G, Langer RD, Elliott JA, Tuunainen A. PMID: 11982677.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    108. Effect of light treatment on sleep and circadian rhythms in demented nursing home patients. J Am Geriatr Soc. 2002 Feb; 50(2):282-9. Ancoli-Israel S, Martin JL, Kripke DF, Marler M, Klauber MR. PMID: 12028210.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCTClinical Trials
    109. Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry. 2002 Feb; 59(2):131-6. Kripke DF, Garfinkel L, Wingard DL, Klauber MR, Marler MR. PMID: 11825133.
      View in: PubMed   Mentions: 475     Fields:    Translation:Humans
    110. Bright-light mask treatment of delayed sleep phase syndrome. J Biol Rhythms. 2002 Feb; 17(1):89-101. Cole RJ, Smith JS, Alcalá YC, Elliott JA, Kripke DF. PMID: 11837952.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    111. Circadian phase-delaying effects of bright light alone and combined with exercise in humans. . 2002 Jan; 282(1):R259-66. Youngstedt SD, Kripke DF, Elliott JA. PMID: 11742846.
      View in: PubMed   Mentions:
    112. Delayed and advanced sleep phase symptoms. Isr J Psychiatry Relat Sci. 2002; 39(1):11-8. Ando K, Kripke DF, Ancoli-Israel S. PMID: 12013705.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    113. Bright light augments antidepressant effects of medication and wake therapy. Depress Anxiety. 2002; 16(1):1-3. Loving RT, Kripke DF, Shuchter SR. PMID: 12203667.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    114. Sleep Complaints of Postmenopausal Women. Clin J Womens Health. 2001 Dec 01; 1(5):244-252. Kripke DF, Brunner R, Freeman R, Hendrix SL, Jackson RD, Masaki K, Carter RA. PMID: 21461131.
      View in: PubMed   Mentions:
    115. Chronic hypnotic use: deadly risks, doubtful benefit. REVIEW ARTICLE. Sleep Med Rev. 2000 Feb; 4(1):5-20. Kripke DF. PMID: 12531158.
      View in: PubMed   Mentions: 29     Fields:    
    116. Light treatment for nonseasonal depression: speed, efficacy, and combined treatment. J Affect Disord. 1998 May; 49(2):109-17. Kripke DF. PMID: 9609674.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCTClinical Trials
    117. Melatonin: marvel or marker? Ann Med. 1998 Feb; 30(1):81-7. Kripke DF, Elliot JA, Youngstedt SD, Smith JS. PMID: 9556093.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
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