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    Chi-Hua Chen

    TitleAssistant Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentRadiology
    Address9500 Gilman Drive #0841
    CA La Jolla 92093
    Phone858-822-3865
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of CambridgePhDDepartment of Psychiatry
      Imperial College LondonMScDepartment of Neuroscience
      National Taiwan UniversityBScDepartment of Pharmacy

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Identifying the Polygenic Basis of the Human Brain and Psychiatric Disorders
      NIH R01MH100351Jul 1, 2013 - Jun 30, 2018
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lo MT, Hinds DA, Tung JY, Franz C, Fan CC, Wang Y, Smeland OB, Schork A, Holland D, Kauppi K, Sanyal N, Escott-Price V, Smith DJ, O'Donovan M, Stefansson H, Bjornsdottir G, Thorgeirsson TE, Stefansson K, McEvoy LK, Dale AM, Andreassen OA, Chen C . Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nature Genetics. 2016.
      2. Peng Q, Schork A, Bartsch H, Lo MT, Panizzon MS, Pediatric Imaging, Neurocognition and Genetics Study, Alzheimer’s Disease Neuroimaging Initiative, Westlye LT, Kremen WS, Jernigan TL, Hellard SL, Steen VM, Espeseth T, Huentelman M, Håberg AK, Agartz I, Djurovic S, Andreassen OA, Dale AM, Schork NJ, and Chen CH. Conservation of Distinct Genetically-Mediated Human Cortical Pattern. PLoS Genet. 2016; 12(7).
      3. Braddick O, Atkinson J, Newman E, Akshoomoff N, Kuperman JM, Bartsch H, Chen C, Dale AM, Jernigan TL. Global Visual Motion Sensitivity: Associations with Parietal Area and Children's Mathematical Cognition. J Cogn Neurosci. 2016 Jul 26; 1-12. PMID: 27458748.
        View in: PubMed
      4. Cui J, Chen C, Lo MT, Schork N, Bettencourt R, Gonzalez MP, Bhatt A, Hooker J, Shaffer K, Nelson KE, Long MT, Brenner DA, Sirlin CB, Loomba R. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Hepatology. 2016 Jun 17. PMID: 27315352.
        View in: PubMed
      5. Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen C, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH, Andreassen OA, Dale AM, Desikan RS. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. JAMA Neurol. 2016 Jun 1; 73(6):691-7. PMID: 27088644.
        View in: PubMed
      6. Holland D, Wang Y, Thompson WK, Schork A, Chen C, Lo MT, Witoelar A. Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics. Front Genet. 2016; 7:15. PMID: 26909100.
        View in: PubMed
      7. Vuoksimaa E, Panizzon MS, Chen C, Fiecas M, Eyler LT, Fennema-Notestine C, Hagler DJ, Franz CE, Jak AJ, Lyons MJ, Neale MC, Rinker DA, Thompson WK, Tsuang MT, Dale AM, Kremen WS. Is bigger always better? The importance of cortical configuration with respect to cognitive ability. Neuroimage. 2016 Apr 1; 129:356-66. PMID: 26827810.
        View in: PubMed
      8. Wang Y, Thompson WK, Schork AJ, Holland D, Chen C, Bettella F, Desikan RS, Li W, Witoelar A, Zuber V, Devor A. Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS. PLoS Genet. 2016 Jan; 12(1):e1005803. PMID: 26808560.
        View in: PubMed
      9. Chen C, Chen YC, Chiang MC, Fung HC, Chang KH, Lee-Chen GJ, Wu YR. Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan. Neurobiol Aging. 2016 Mar; 39:221.e1-5. PMID: 26804608.
        View in: PubMed
      10. Román FJ, Lewis LB, Chen C, Karama S, Burgaleta M, Martínez K, Lepage C, Jaeggi SM, Evans AC, Kremen WS, Colom R. Gray matter responsiveness to adaptive working memory training: a surface-based morphometry study. Brain Struct Funct. 2015 Dec 23. PMID: 26701168.
        View in: PubMed
      11. Fjell AM, Grydeland H, Krogsrud SK, Amlien I, Rohani DA, Ferschmann L, Storsve AB, Tamnes CK, Sala-Llonch R, Due-Tønnessen P, Bjørnerud A, Sølsnes AE, Håberg AK, Skranes J, Bartsch H, Chen C, Thompson WK, Panizzon MS, Kremen WS, Dale AM, Walhovd KB. Development and aging of cortical thickness correspond to genetic organization patterns. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15462-7. PMID: 26575625.
        View in: PubMed
      12. Newman E, Jernigan TL, Lisdahl KM, Tamm L, Tapert SF, Potkin SG, Mathalon D, Molina B, Bjork J, Castellanos FX, Swanson J, Kuperman JM, Bartsch H, Chen C, Dale AM, Epstein JN, Group MN. Go/No Go task performance predicts cortical thickness in the caudal inferior frontal gyrus in young adults with and without ADHD. Brain Imaging Behav. 2015 Sep 24. PMID: 26404018.
        View in: PubMed
      13. Loomba R, Schork N, Chen C, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin CB, Brenner D. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology. 2015 Aug 20. PMID: 26299412.
        View in: PubMed
      14. Docherty AR, Sawyers CK, Panizzon MS, Neale MC, Eyler LT, Fennema-Notestine C, Franz CE, Chen C, McEvoy LK, Verhulst B, Tsuang MT, Kremen WS. Genetic network properties of the human cortex based on regional thickness and surface area measures. Front Hum Neurosci. 2015; 9:440. PMID: 26347632.
        View in: PubMed
      15. Chen C, Peng Q, Schork AJ, Lo MT, Fan CC, Wang Y, Desikan RS, Bettella F, Hagler DJ. Large-scale genomics unveil polygenic architecture of human cortical surface area. Nat Commun. 2015; 6:7549. PMID: 26189703.
        View in: PubMed
      16. Newman E, Thompson WK, Bartsch H, Hagler DJ, Chen C, Brown TT, Kuperman JM, McCabe C, Chung Y, Libiger O, Akshoomoff N, Bloss CS, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Kennedy DN, Murray SS, Sowell ER, Schork N, Kenet T, Kaufmann WE, Mostofsky S, Amaral DG, Dale AM, Jernigan TL. Anxiety is related to indices of cortical maturation in typically developing children and adolescents. Brain Struct Funct. 2015 Jul 17. PMID: 26183468.
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      17. Fan CC, Bartsch H, Schork AJ, Chen C, Wang Y, Lo MT, Brown TT, Kuperman JM, Hagler DJ, Schork NJ, Jernigan TL, Dale AM. Modeling the 3D Geometry of the Cortical Surface with Genetic Ancestry. Curr Biol. 2015 Aug 3; 25(15):1988-92. PMID: 26166778.
        View in: PubMed
      18. Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen C, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 2015 Jun 9; 131(23):2061-9. PMID: 25862742.
        View in: PubMed
      19. Desikan RS, Schork AJ, Wang Y, Witoelar A, Sharma M, McEvoy LK, Holland D, Brewer JB, Chen C, Thompson WK, Harold D, Williams J, Owen MJ, O'Donovan MC, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Schellenberg GD, Heutink P, Singleton AB, Brice A, Wood NW, Hardy J, Martinez M, Choi SH, DeStefano A, Ikram MA, Bis JC, Smith A, Fitzpatrick AL, Launer L, van Duijn C, Seshadri S, Ulstein ID, Aarsland D, Fladby T, Djurovic S, Hyman BT, Snaedal J, Stefansson H, Stefansson K, Gasser T, Andreassen OA, Dale AM. Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Mol Psychiatry. 2015 Feb 17. PMID: 25687773.
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      20. Lewis GJ, Panizzon MS, Eyler L, Fennema-Notestine C, Chen C, Neale MC, Jernigan TL, Lyons MJ, Dale AM, Kremen WS, Franz CE. Heritable influences on amygdala and orbitofrontal cortex contribute to genetic variation in core dimensions of personality. Neuroimage. 2014 Dec; 103:309-15. PMID: 25263286.
        View in: PubMed
      21. Vuoksimaa E, Panizzon MS, Chen C, Fiecas M, Eyler LT, Fennema-Notestine C, Hagler DJ, Fischl B, Franz CE, Jak A, Lyons MJ, Neale MC, Rinker DA, Thompson WK, Tsuang MT, Dale AM, Kremen WS. The Genetic Association Between Neocortical Volume and General Cognitive Ability Is Driven by Global Surface Area Rather Than Thickness. Cereb Cortex. 2014 Feb 18. PMID: 24554725.
        View in: PubMed
      22. Eyler LT, Vuoksimaa E, Panizzon MS, Fennema-Notestine C, Neale MC, Chen C, Jak A, Franz CE, Lyons MJ, Thompson WK, Spoon KM, Fischl B, Dale AM, Kremen WS. Conceptual and Data-based Investigation of Genetic Influences and Brain Asymmetry: A Twin Study of Multiple Structural Phenotypes. J Cogn Neurosci. 2014 May; 26(5):1100-17. PMID: 24283492.
        View in: PubMed
      23. Kremen WS, Fennema-Notestine C, Eyler LT, Panizzon MS, Chen C, Franz CE, Lyons MJ, Thompson WK, Dale AM. Genetics of brain structure: contributions from the Vietnam Era Twin Study of Aging. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):751-61. PMID: 24132907.
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      24. Chen C, Fiecas M, Gutiérrez ED, Panizzon MS, Eyler LT, Vuoksimaa E, Thompson WK, Fennema-Notestine C, Hagler DJ, Jernigan TL, Neale MC, Franz CE, Lyons MJ, Fischl B, Tsuang MT, Dale AM, Kremen WS. Genetic topography of brain morphology. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):17089-94. PMID: 24082094.
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      25. Andreassen OA, Thompson WK, Schork AJ, Ripke S, Mattingsdal M, Kelsoe JR, Kendler KS, O'Donovan MC, Rujescu D, Werge T, Sklar P. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genet. 2013 Apr; 9(4):e1003455. PMID: 23637625.
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      26. Vuoksimaa E, Panizzon MS, Chen C, Eyler LT, Fennema-Notestine C, Fiecas MJ, Fischl B, Franz CE, Grant MD, Jak AJ, Lyons MJ, Neale MC, Thompson WK, Tsuang MT, Xian H, Dale AM, Kremen WS. Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age. Neuropsychologia. 2013 May; 51(6):1124-31. PMID: 23499725.
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      27. Eyler LT, Chen C, Panizzon MS, Fennema-Notestine C, Neale MC, Jak A, Jernigan TL, Fischl B, Franz CE, Lyons MJ, Grant M, Prom-Wormley E, Seidman LJ, Tsuang MT, Fiecas MJ, Dale AM, Kremen WS. A comparison of heritability maps of cortical surface area and thickness and the influence of adjustment for whole brain measures: a magnetic resonance imaging twin study. Twin Res Hum Genet. 2012 Jun; 15(3):304-14. PMID: 22856366.
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      28. Chen C, Gutierrez ED, Thompson W, Panizzon MS, Jernigan TL, Eyler LT, Fennema-Notestine C, Jak AJ, Neale MC, Franz CE, Lyons MJ, Grant MD, Fischl B, Seidman LJ, Tsuang MT, Kremen WS, Dale AM. Hierarchical genetic organization of human cortical surface area. Science. 2012 Mar 30; 335(6076):1634-6. PMID: 22461613.
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      29. Panizzon MS, Fennema-Notestine C, Kubarych TS, Chen C, Eyler LT, Fischl B, Franz CE, Grant MD, Hamza S, Jak A, Jernigan TL, Lyons MJ, Neale MC, Prom-Wormley EC, Seidman L, Tsuang MT, Wu H, Xian H, Dale AM, Kremen WS. Genetic and environmental influences of white and gray matter signal contrast: a new phenotype for imaging genetics? Neuroimage. 2012 Apr 15; 60(3):1686-95. PMID: 22500923.
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      30. Chen C, Panizzon MS, Eyler LT, Jernigan TL, Thompson W, Fennema-Notestine C, Jak AJ, Neale MC, Franz CE, Hamza S, Lyons MJ, Grant MD, Fischl B, Seidman LJ, Tsuang MT, Kremen WS, Dale AM. Genetic influences on cortical regionalization in the human brain. Neuron. 2011 Nov 17; 72(4):537-44. PMID: 22099457.
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      31. Panizzon MS, Hauger RL, Eaves LJ, Chen C, Dale AM, Eyler LT, Fischl B, Fennema-Notestine C, Franz CE, Grant MD, Jacobson KC, Jak AJ, Lyons MJ, Mendoza SP, Neale MC, Prom-Wormley E, Seidman LJ, Tsuang MT, Xian H, Kremen WS. Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men. Neuroimage. 2012 Jan 16; 59(2):1123-31. PMID: 21983185.
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      32. Eyler LT, Prom-Wormley E, Panizzon MS, Kaup AR, Fennema-Notestine C, Neale MC, Jernigan TL, Fischl B, Franz CE, Lyons MJ, Grant M, Stevens A, Pacheco J, Perry ME, Schmitt JE, Seidman LJ, Thermenos HW, Tsuang MT, Chen C, Thompson WK, Jak A, Dale AM, Kremen WS. Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin study. Cereb Cortex. 2011 Oct; 21(10):2313-21. PMID: 21378112.
        View in: PubMed
      33. Chen C, Suckling J, Lennox BR, Ooi C, Bullmore ET. A quantitative meta-analysis of fMRI studies in bipolar disorder. Bipolar Disord. 2011 Feb; 13(1):1-15. PMID: 21320248.
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      34. Chen C, Zeki S. Frontoparietal activation distinguishes face and space from artifact concepts. J Cogn Neurosci. 2011 Sep; 23(9):2558-68. PMID: 21254806.
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      35. Fennema-Notestine C, Panizzon MS, Thompson WR, Chen C, Eyler LT, Fischl B, Franz CE, Grant MD, Jak AJ, Jernigan TL, Lyons MJ, Neale MC, Seidman LJ, Tsuang MT, Xian H, Dale AM, Kremen WS. Presence of ApoE e4 allele associated with thinner frontal cortex in middle age. J Alzheimers Dis. 2011; 26 Suppl 3:49-60. PMID: 21971450.
        View in: PubMed
      36. Chen C, Suckling J, Ooi C, Jacob R, Lupson V, Bullmore ET, Lennox BR. A longitudinal fMRI study of the manic and euthymic states of bipolar disorder. Bipolar Disord. 2010 May; 12(3):344-7. PMID: 20565443.
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      37. Suckling J, Ohlssen D, Andrew C, Johnson G, Williams SC, Graves M, Chen C, Spiegelhalter D, Bullmore E. Components of variance in a multicentre functional MRI study and implications for calculation of statistical power. Hum Brain Mapp. 2008 Oct; 29(10):1111-22. PMID: 17680602.
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      38. Chen C, Suckling J, Ooi C, Fu CH, Williams SC, Walsh ND, Mitterschiffthaler MT, Pich EM, Bullmore E. Functional coupling of the amygdala in depressed patients treated with antidepressant medication. Neuropsychopharmacology. 2008 Jul; 33(8):1909-18. PMID: 17987064.
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      39. Menzies L, Achard S, Chamberlain SR, Fineberg N, Chen C, del Campo N, Sahakian BJ, Robbins TW, Bullmore E. Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain. 2007 Dec; 130(Pt 12):3223-36. PMID: 17855376.
        View in: PubMed
      40. Chen C, Ridler K, Suckling J, Williams S, Fu CH, Merlo-Pich E, Bullmore E. Brain imaging correlates of depressive symptom severity and predictors of symptom improvement after antidepressant treatment. Biol Psychiatry. 2007 Sep 1; 62(5):407-14. PMID: 17217921.
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      41. Hammers A, Chen C, Lemieux L, Allom R, Vossos S, Free SL, Myers R, Brooks DJ, Duncan JS, Koepp MJ. Statistical neuroanatomy of the human inferior frontal gyrus and probabilistic atlas in a standard stereotaxic space. Hum Brain Mapp. 2007 Jan; 28(1):34-48. PMID: 16671082.
        View in: PubMed
      42. Chen C, Lennox B, Jacob R, Calder A, Lupson V, Bisbrown-Chippendale R, Suckling J, Bullmore E. Explicit and implicit facial affect recognition in manic and depressed States of bipolar disorder: a functional magnetic resonance imaging study. Biol Psychiatry. 2006 Jan 1; 59(1):31-9. PMID: 16112653.
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