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Nathan Shaner

Title(s)Associate Adjunct Professor, Neurosciences
SchoolHealth Sciences
Phone858-534-8182
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    Collapse Research 
    Collapse Research Activities and Funding
    Highly specific control of neurons with photoswitchable bioluminescent optogenetics.
    NIH/NEI R21EY030716Aug 1, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Probes for Luminescence-based Superresolution Microscopy
    NIH/NIGMS R01GM121944Feb 16, 2017 - Jan 31, 2021
    Role: Principal Investigator
    BioLuminescent OptoGenetics (BL-OG): A Novel and Versatile Strategy for Neuromodulation
    NIH/NINDS U01NS099709Sep 30, 2016 - Jun 30, 2019
    Role: Co-Principal Investigator
    Fluorescent proteins for superresolution imaging
    NIH/NIGMS R01GM109984Sep 30, 2014 - Aug 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. de Heuvel E, Singh AK, Boronat P, Kooistra AJ, van der Meer T, Sadek P, Blaazer AR, Shaner NC, Bindels DS, Caljon G, Maes L, Sterk GJ, Siderius M, Oberholzer M, de Esch IJP, Brown DG, Leurs R. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2). Bioorg Med Chem. 2019 Sep 15; 27(18):4013-4029. PMID: 31378593.
      View in: PubMed
    2. Tewson P, Martinka S, Shaner N, Berlot C, Quinn AM, Hughes T. Assay for Detecting Gai-Mediated Decreases in cAMP in Living Cells. SLAS Discov. 2018 10; 23(9):898-906. PMID: 29991302.
      View in: PubMed
    3. Hong SR, Wang CL, Huang YS, Chang YC, Chang YC, Pusapati GV, Lin CY, Hsu N, Cheng HC, Chiang YC, Huang WE, Shaner NC, Rohatgi R, Inoue T, Lin YC. Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling. Nat Commun. 2018 04 30; 9(1):1732. PMID: 29712905.
      View in: PubMed
    4. Mastop M, Bindels DS, Shaner NC, Postma M, Gadella TWJ, Goedhart J. Characterization of a spectrally diverse set of fluorescent proteins as FRET acceptors for mTurquoise2. Sci Rep. 2017 09 20; 7(1):11999. PMID: 28931898.
      View in: PubMed
    5. Molina RS, Tran TM, Campbell RE, Lambert GG, Salih A, Shaner NC, Hughes TE, Drobizhev M. Blue-Shifted Green Fluorescent Protein Homologues Are Brighter than Enhanced Green Fluorescent Protein under Two-Photon Excitation. J Phys Chem Lett. 2017 Jun 15; 8(12):2548-2554. PMID: 28530831.
      View in: PubMed
    6. Shen Y, Chen Y, Wu J, Shaner NC, Campbell RE. Engineering of mCherry variants with long Stokes shift, red-shifted fluorescence, and low cytotoxicity. PLoS One. 2017; 12(2):e0171257. PMID: 28241009.
      View in: PubMed
    7. Clavel D, Gotthard G, von Stetten D, De Sanctis D, Pasquier H, Lambert GG, Shaner NC, Royant A. Structural analysis of the bright monomeric yellow-green fluorescent protein mNeonGreen obtained by directed evolution. Acta Crystallogr D Struct Biol. 2016 12 01; 72(Pt 12):1298-1307. PMID: 27917830.
      View in: PubMed
    8. Tewson PH, Martinka S, Shaner NC, Hughes TE, Quinn AM. New DAG and cAMP Sensors Optimized for Live-Cell Assays in Automated Laboratories. J Biomol Screen. 2016 Mar; 21(3):298-305. PMID: 26657040.
      View in: PubMed
    9. Fujita K, Nagai T, Shaner N, Egner A. Special Section Guest Editorial: Protein Photonics for Imaging, Sensing, and Manipulation: Honoring Prof. Osamu Shimomura, a Pioneer of Photonics for Biomedical Research. J Biomed Opt. 2015 Oct; 20(10):101201. PMID: 26527157.
      View in: PubMed
    10. Francis WR, Shaner NC, Christianson LM, Powers ML, Haddock SH. Occurrence of Isopenicillin-N-Synthase Homologs in Bioluminescent Ctenophores and Implications for Coelenterazine Biosynthesis. PLoS One. 2015; 10(6):e0128742. PMID: 26125183.
      View in: PubMed
    11. Shaner NC. Fluorescent proteins for quantitative microscopy: important properties and practical evaluation. Methods Cell Biol. 2014; 123:95-111. PMID: 24974024.
      View in: PubMed
    12. Shaner NC, Lambert GG, Chammas A, Ni Y, Cranfill PJ, Baird MA, Sell BR, Allen JR, Day RN, Israelsson M, Davidson MW, Wang J. A bright monomeric green fluorescent protein derived from Branchiostoma lanceolatum. Nat Methods. 2013 May; 10(5):407-9. PMID: 23524392.
      View in: PubMed
    13. Francis WR, Christianson LM, Kiko R, Powers ML, Shaner NC, Haddock SH. A comparison across non-model animals suggests an optimal sequencing depth for de novo transcriptome assembly. BMC Genomics. 2013 Mar 12; 14:167. PMID: 23496952.
      View in: PubMed
    14. Powers ML, McDermott AG, Shaner NC, Haddock SH. Expression and characterization of the calcium-activated photoprotein from the ctenophore Bathocyroe fosteri: insights into light-sensitive photoproteins. Biochem Biophys Res Commun. 2013 Feb 08; 431(2):360-6. PMID: 23262181.
      View in: PubMed
    15. Shaner NC. The mFruit collection of monomeric fluorescent proteins. Clin Chem. 2013 Feb; 59(2):440-1. PMID: 23213078.
      View in: PubMed
    16. Li H, Foss SM, Dobryy YL, Park CK, Hires SA, Shaner NC, Tsien RY, Osborne LC, Voglmaier SM. Concurrent imaging of synaptic vesicle recycling and calcium dynamics. Front Mol Neurosci. 2011; 4:34. PMID: 22065946.
      View in: PubMed
    17. Siebert S, Robinson MD, Tintori SC, Goetz F, Helm RR, Smith SA, Shaner N, Haddock SH, Dunn CW. Differential gene expression in the siphonophore Nanomia bijuga (Cnidaria) assessed with multiple next-generation sequencing workflows. PLoS One. 2011; 6(7):e22953. PMID: 21829563.
      View in: PubMed
    18. Ewen-Campen B, Shaner N, Panfilio KA, Suzuki Y, Roth S, Extavour CG. The maternal and early embryonic transcriptome of the milkweed bug Oncopeltus fasciatus. BMC Genomics. 2011 Jan 25; 12:61. PMID: 21266083.
      View in: PubMed
    19. Hoi H, Shaner NC, Davidson MW, Cairo CW, Wang J, Campbell RE. A monomeric photoconvertible fluorescent protein for imaging of dynamic protein localization. J Mol Biol. 2010 Sep 03; 401(5):776-91. PMID: 20603133.
      View in: PubMed
    20. Ouyang M, Huang H, Shaner NC, Remacle AG, Shiryaev SA, Strongin AY, Tsien RY, Wang Y. Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer. Cancer Res. 2010 Mar 15; 70(6):2204-12. PMID: 20197470.
      View in: PubMed
    21. Lin MZ, McKeown MR, Ng HL, Aguilera TA, Shaner NC, Campbell RE, Adams SR, Gross LA, Ma W, Alber T, Tsien RY. Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals. Chem Biol. 2009 Nov 25; 16(11):1169-79. PMID: 19942140.
      View in: PubMed
    22. Shaner NC, Lin MZ, McKeown MR, Steinbach PA, Hazelwood KL, Davidson MW, Tsien RY. Improving the photostability of bright monomeric orange and red fluorescent proteins. Nat Methods. 2008 Jun; 5(6):545-51. PMID: 18454154.
      View in: PubMed
    23. Shaner NC, Patterson GH, Davidson MW. Advances in fluorescent protein technology. J Cell Sci. 2007 Dec 15; 120(Pt 24):4247-60. PMID: 18057027.
      View in: PubMed
    24. Ai HW, Shaner NC, Cheng Z, Tsien RY, Campbell RE. Exploration of new chromophore structures leads to the identification of improved blue fluorescent proteins. Biochemistry. 2007 May 22; 46(20):5904-10. PMID: 17444659.
      View in: PubMed
    25. Shu X, Shaner NC, Yarbrough CA, Tsien RY, Remington SJ. Novel chromophores and buried charges control color in mFruits. Biochemistry. 2006 Aug 15; 45(32):9639-47. PMID: 16893165.
      View in: PubMed
    26. Shaner NC, Steinbach PA, Tsien RY. A guide to choosing fluorescent proteins. Nat Methods. 2005 Dec; 2(12):905-9. PMID: 16299475.
      View in: PubMed
    27. Wang J, Shaner N, Mittal B, Zhou Q, Chen J, Sanger JM, Sanger JW. Dynamics of Z-band based proteins in developing skeletal muscle cells. Cell Motil Cytoskeleton. 2005 May; 61(1):34-48. PMID: 15810059.
      View in: PubMed
    28. Shaner NC, Sanger JW, Sanger JM. Actin and alpha-actinin dynamics in the adhesion and motility of EPEC and EHEC on host cells. Cell Motil Cytoskeleton. 2005 Feb; 60(2):104-20. PMID: 15627283.
      View in: PubMed
    29. Shaner NC, Campbell RE, Steinbach PA, Giepmans BN, Palmer AE, Tsien RY. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol. 2004 Dec; 22(12):1567-72. PMID: 15558047.
      View in: PubMed
    30. Sanger JW, Chowrashi P, Shaner NC, Spalthoff S, Wang J, Freeman NL, Sanger JM. Myofibrillogenesis in skeletal muscle cells. Clin Orthop Relat Res. 2002 Oct; (403 Suppl):S153-62. PMID: 12394464.
      View in: PubMed
    31. Ayoob JC, Shaner NC, Sanger JW, Sanger JM. Expression of green or red fluorescent protein (GFP or DsRed) linked proteins in nonmuscle and muscle cells. Mol Biotechnol. 2001 Jan; 17(1):65-71. PMID: 11280932.
      View in: PubMed