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    James Lohr

    TitleSenate Emeritus
    SchoolUniversity of California, San Diego
    DepartmentPsychiatry
    Address9500 Gilman Drive #9116-A
    CA La Jolla 92093
    Phone858-552-8585
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      Biography

      Dr. Lohr received his BA from the University of Chicago and MD from the Pritzker School of Medicine at the University of Chicago. From there, he went to the University of Pittsburgh where he completed his residency in General Psychiatry at the Western Psychiatric Institute and Clinics, and then completed a Neuropsychiatry Fellowship at the National Institute of Mental Health in Washington DC. He joined the Department of Psychiatry faculty at UCSD in 1987, and for 12 years was the Chief of Psychiatry at the VA San Diego Healthcare System. For the last three years he has been Vice Chair for Clinical Affairs in the Department of Psychiatry at UCSD, and Clinical Service Chief for the Department as well. He oversees the clinical operations for all mental health services at UCSD. He is also the Director of the Psychopharmacology Research Initiatives Center of Excellence (PRICE) in the Department of Psychiatry, which coordinates studies of psychotropic medications.

      Research Interests

      Dr. Lohr’s primary research interest has been neuropsychiatric movement disorders and the major psychotic illnesses of schizophrenia and bipolar disorder. He has been involved in studies of motor function, brain imaging, oxidative metabolism, and lateralized hemispheric functioning in these disorders, as well as studies of psychopharmacology and of healthcare systems and delivery.

      Clinical Focus

      Dr. Lohr’s primary clinical focus is on serious mental disorders, predominantly the major psychotic disorders of schizophrenia, schizoaffective disorder, and bipolar disorder.


      Collapse Research 
      Collapse Research Activities and Funding
      Accelerated Aging among Veterans with PTSD
      VA I01CX001351Apr 1, 2017 - Mar 31, 2021
      Role: Principal Investigator
      MOTOR/COGNITIVE ASYMMETRY IN OLDER PSYCHOTIC PATIENTS
      NIH/NIMH R01MH057140Sep 1, 1998 - May 31, 2003
      Role: Principal Investigator
      TARDIVE DYSKINESIA: FREE RADICAL MECHANISMS &VITAMIN E
      NIH/NIMH R29MH045142Aug 1, 1989 - Jul 31, 1994
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Pittman JO, Floto E, Lindamer L, Baker DG, Lohr J, Afari N. VA eScreening program: Technology to improve care for post-9/11 veterans. Psychol Serv. 2017 Feb; 14(1):23-33. PMID: 28134554.
        View in: PubMed
      2. Lohr J, Eidt CA, Abdulrazzaq Alfaraj A, Soliman MA. The clinical challenges of akathisia. CNS Spectr. 2015 Dec; 20 Suppl 1:1-16. PMID: 26683525.
        View in: PubMed
      3. Twamley EW, Thomas KR, Gregory AM, Jak AJ, Bondi MW, Delis DC, Lohr J. CogSMART Compensatory Cognitive Training for Traumatic Brain Injury: Effects Over 1 Year. J Head Trauma Rehabil. 2015 Nov-Dec; 30(6):391-401. PMID: 25033034.
        View in: PubMed
      4. McAllister TW, Zafonte R, Jain S, Flashman LA, George MS, Grant GA, He F, Lohr J, Andaluz N, Summerall L, Paulus MP, Raman R, Stein MB. Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury. Neuropsychopharmacology. 2016 Apr; 41(5):1191-8. PMID: 26361060.
        View in: PubMed
      5. Lohr J, Palmer BW, Eidt CA, Aailaboyina S, Mausbach BT, Wolkowitz OM, Thorp SR, Jeste DV. Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature. Am J Geriatr Psychiatry. 2015 Jul; 23(7):709-25. PMID: 25959921.
        View in: PubMed
      6. Caligiuri MP, Teulings HL, Dean CE, Lohr J. A quantitative measure of handwriting dysfluency for assessing tardive dyskinesia. J Clin Psychopharmacol. 2015 Apr; 35(2):168-74. PMID: 25679121.
        View in: PubMed
      7. Tylee DS, Chandler SD, Nievergelt CM, Liu X, Pazol J, Woelk CH, Lohr J, Kremen WS. Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: A pilot study. Psychoneuroendocrinology. 2015 Jan; 51:472-94. PMID: 25311155.
        View in: PubMed
      8. Agorastos A, Hauger RL, Barkauskas DA, Moeller-Bertram T, Clopton PL, Haji U, Lohr J, Geracioti TD, Patel PM, Chrousos GP, Baker DG. Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men. Psychoneuroendocrinology. 2014 Jun; 44:71-82. PMID: 24767621.
        View in: PubMed
      9. Franz CE, Lyons MJ, Spoon KM, Hauger RL, Jacobson KC, Lohr J, McKenzie R, Panizzon MS, Thompson WK, Tsuang MT, Vasilopoulos T, Vuoksimaa E, Xian H, Kremen WS. Post-traumatic Stress Symptoms and Adult Attachment: A 24-year Longitudinal Study. Am J Geriatr Psychiatry. 2014 Feb 19. PMID: 24636844.
        View in: PubMed
      10. Sorg SF, Delano-Wood L, Luc N, Schiehser DM, Hanson KL, Nation DA, Lanni E, Jak AJ, Lu K, Meloy MJ, Frank LR, Lohr J, Bondi MW. White matter integrity in veterans with mild traumatic brain injury: associations with executive function and loss of consciousness. J Head Trauma Rehabil. 2014 Jan-Feb; 29(1):21-32. PMID: 23640539.
        View in: PubMed
      11. Lohr J, Liu L, Caligiuri MP, Kash TP, May TA, Murphy JD, Ancoli-Israel S. Modafinil improves antipsychotic-induced parkinsonism but not excessive daytime sleepiness, psychiatric symptoms or cognition in schizophrenia and schizoaffective disorder: a randomized, double-blind, placebo-controlled study. Schizophr Res. 2013 Oct; 150(1):289-96. PMID: 23938173.
        View in: PubMed
      12. Twamley EW, Baker DG, Norman SB, Pittman JO, Lohr J, Resnick SG. Veterans Health Administration vocational services for Operation Iraqi Freedom/Operation Enduring Freedom Veterans with mental health conditions. J Rehabil Res Dev. 2013 Aug; 50(5):663-70. PMID: 24013914.
        View in: PubMed
      13. Acheson D, Feifel D, de Wilde S, McKinney R, Lohr J, Risbrough V. The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample. Psychopharmacology (Berl). 2013 Sep; 229(1):199-208. PMID: 23644911.
        View in: PubMed
      14. Schuitevoerder S, Rosen JW, Twamley EW, Ayers CR, Sones H, Lohr J, Goetter EM, Fonzo GA, Holloway KJ, Thorp SR. A meta-analysis of cognitive functioning in older adults with PTSD. J Anxiety Disord. 2013 Aug; 27(6):550-8. PMID: 23422492.
        View in: PubMed
      15. Agorastos A, Nash WP, Nunnink S, Yurgil KA, Goldsmith A, Litz BT, Johnson H, Lohr J, Baker DG. The Peritraumatic Behavior Questionnaire: development and initial validation of a new measure for combat-related peritraumatic reactions. BMC Psychiatry. 2013; 13:9. PMID: 23289606.
        View in: PubMed
      16. Smith RC, Jin H, Li C, Bark N, Shekhar A, Dwivedi S, Mortiere C, Lohr J, Hu Q, Davis JM. Effects of pioglitazone on metabolic abnormalities, psychopathology, and cognitive function in schizophrenic patients treated with antipsychotic medication: a randomized double-blind study. Schizophr Res. 2013 Jan; 143(1):18-24. PMID: 23200554.
        View in: PubMed
      17. Matthews SC, Spadoni AD, Lohr J, Strigo IA, Simmons AN. Diffusion tensor imaging evidence of white matter disruption associated with loss versus alteration of consciousness in warfighters exposed to combat in Operations Enduring and Iraqi Freedom. Psychiatry Res. 2012 Nov 30; 204(2-3):149-54. PMID: 23149025.
        View in: PubMed
      18. Heppner PS, Lohr J, Kash TP, Jin H, Wang H, Baker DG. Metabolic syndrome: relative risk associated with post-traumatic stress disorder (PTSD) severity and antipsychotic medication use. Psychosomatics. 2012 Nov-Dec; 53(6):550-8. PMID: 23157993.
        View in: PubMed
      19. Lohr J, May T, Caligiuri MP. Quantitative assessment of motor abnormalities in untreated patients with major depressive disorder. J Affect Disord. 2013 Mar 20; 146(1):84-90. PMID: 22985485.
        View in: PubMed
      20. Simmons AN, Flagan TM, Wittmann M, Strigo IA, Matthews SC, Donovan H, Lohr J, Paulus MP. The effects of temporal unpredictability in anticipation of negative events in combat veterans with PTSD. J Affect Disord. 2013 Apr 25; 146(3):426-32. PMID: 22910447.
        View in: PubMed
      21. Acheson DT, Stein MB, Paulus MP, Ravindran L, Simmons AN, Lohr J, Risbrough VB. Effects of anxiolytic treatment on potentiated startle during aversive image anticipation. Hum Psychopharmacol. 2012 Jul; 27(4):419-27. PMID: 22782542.
        View in: PubMed
      22. Backhaus A, Agha Z, Maglione ML, Repp A, Ross B, Zuest D, Rice-Thorp NM, Lohr J, Thorp SR. Videoconferencing psychotherapy: a systematic review. Psychol Serv. 2012 May; 9(2):111-31. PMID: 22662727.
        View in: PubMed
      23. Brown GG, Lee JS, Strigo IA, Caligiuri MP, Meloy MJ, Lohr J. Voxel-based morphometry of patients with schizophrenia or bipolar I disorder: a matched control study. Psychiatry Res. 2011 Nov 30; 194(2):149-56. PMID: 21924872.
        View in: PubMed
      24. Wang H, Jin H, Nunnink SE, Guo W, Sun J, Shi J, Zhao B, Bi Y, Yan T, Yu H, Wang G, Gao Z, Zhao H, Ou Y, Song Z, Chen F, Lohr J, Baker DG. Identification of post traumatic stress disorder and risk factors in military first responders 6 months after Wen Chuan earthquake in China. J Affect Disord. 2011 Apr; 130(1-2):213-9. PMID: 20950864.
        View in: PubMed
      25. Bousman CA, Chana G, Glatt SJ, Chandler SD, May T, Lohr J, Kremen WS, Tsuang MT, Everall IP. Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood. Am J Med Genet B Neuropsychiatr Genet. 2010 Oct 5; 153B(7):1336-41. PMID: 20552680.
        View in: PubMed
      26. Caligiuri MP, Teulings HL, Dean CE, Niculescu AB, Lohr J. Handwriting movement kinematics for quantifying extrapyramidal side effects in patients treated with atypical antipsychotics. Psychiatry Res. 2010 May 15; 177(1-2):77-83. PMID: 20381875.
        View in: PubMed
      27. Bousman CA, Chana G, Glatt SJ, Chandler SD, Lucero GR, Tatro E, May T, Lohr J, Kremen WS, Tsuang MT, Everall IP. Preliminary evidence of ubiquitin proteasome system dysregulation in schizophrenia and bipolar disorder: convergent pathway analysis findings from two independent samples. Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5; 153B(2):494-502. PMID: 19582768.
        View in: PubMed
      28. Hawthorne WB, Green EE, Folsom D, Lohr J. A randomized study comparing the treatment environment in alternative and hospital-based acute psychiatric care. Psychiatr Serv. 2009 Sep; 60(9):1239-44. PMID: 19723739.
        View in: PubMed
      29. Caligiuri MP, Teulings HL, Dean CE, Niculescu AB, Lohr J. Handwriting movement analyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone. Hum Mov Sci. 2009 Oct; 28(5):633-42. PMID: 19692133.
        View in: PubMed
      30. Brown GG, Lohr J, Notestine R, Turner T, Gamst A, Eyler LT. Performance of schizophrenia and bipolar patients on verbal and figural working memory tasks. J Abnorm Psychol. 2007 Nov; 116(4):741-53. PMID: 18020720.
        View in: PubMed
      31. Ozdemir V, Williams-Jones B, Graham JE, Preskorn SH, Gripeos D, Glatt SJ, Friis RH, Reist C, Szabo S, Lohr J, Someya T. Asymmetry in scientific method and limits to cross-disciplinary dialogue: toward a shared language and science policy in pharmacogenomics and human disease genetics. J Investig Med. 2007 Apr; 55(3):130-41. PMID: 17481382.
        View in: PubMed
      32. Niculescu AB, Lulow LL, Ogden CA, Le-Niculescu H, Salomon DR, Schork NJ, Caligiuri MP, Lohr J. PhenoChipping of psychotic disorders: a novel approach for deconstructing and quantitating psychiatric phenotypes. Am J Med Genet B Neuropsychiatr Genet. 2006 Sep 5; 141B(6):653-62. PMID: 16838358.
        View in: PubMed
      33. Ozdemir V, Williams-Jones B, Glatt SJ, Tsuang MT, Lohr J, Reist C. Shifting emphasis from pharmacogenomics to theragnostics. Nat Biotechnol. 2006 Aug; 24(8):942-6. PMID: 16900136.
        View in: PubMed
      34. Lohr J, Hellige JB, Cherry BJ, Lulow L, Kwok W, Caligiuri MP. Impaired hemispheric communication in schizophrenia: a study using the consonant-vowel-consonant task. Schizophr Res. 2006 Oct; 87(1-3):279-88. PMID: 16822652.
        View in: PubMed
      35. Caligiuri MP, Teulings HL, Filoteo JV, Song D, Lohr J. Quantitative measurement of handwriting in the assessment of drug-induced parkinsonism. Hum Mov Sci. 2006 Oct; 25(4-5):510-22. PMID: 16647772.
        View in: PubMed
      36. Caligiuri MP, Brown GG, Meloy MJ, Eberson S, Niculescu AB, Lohr J. Striatopallidal regulation of affect in bipolar disorder. J Affect Disord. 2006 Apr; 91(2-3):235-42. PMID: 16503055.
        View in: PubMed
      37. Ozdemir V, Aklillu E, Mee S, Bertilsson L, Albers LJ, Graham JE, Caligiuri M, Lohr J, Reist C. Pharmacogenetics for off-patent antipsychotics: reframing the risk for tardive dyskinesia and access to essential medicines. Expert Opin Pharmacother. 2006 Feb; 7(2):119-33. PMID: 16433578.
        View in: PubMed
      38. Lohr J, Caligiuri MP. Abnormalities in motor physiology in bipolar disorder. J Neuropsychiatry Clin Neurosci. 2006; 18(3):342-9. PMID: 16963583.
        View in: PubMed
      39. Hawthorne WB, Green EE, Gilmer T, Garcia P, Hough RL, Lee M, Hammond L, Lohr J. A randomized trial of short-term acute residential treatment for veterans. Psychiatr Serv. 2005 Nov; 56(11):1379-86. PMID: 16282256.
        View in: PubMed
      40. Caligiuri MP, Hellige JB, Cherry BJ, Kwok W, Lulow LL, Lohr J. Lateralized cognitive dysfunction and psychotic symptoms in schizophrenia. Schizophr Res. 2005 Dec 15; 80(2-3):151-61. PMID: 16125374.
        View in: PubMed
      41. Caligiuri MP, Brown GG, Meloy MJ, Eyler LT, Kindermann SS, Eberson S, Frank LR, Lohr J. A functional magnetic resonance imaging study of cortical asymmetry in bipolar disorder. Bipolar Disord. 2004 Jun; 6(3):183-96. PMID: 15117397.
        View in: PubMed
      42. Brown GG, Caligiuri M, Meloy MJ, Eberson SC, Kindermann SS, Frank LR, Eyler Zorrilla LT, Lohr J. Functional brain asymmetries during visuomotor tracking. J Clin Exp Neuropsychol. 2004 May; 26(3):356-68. PMID: 15512926.
        View in: PubMed
      43. Caligiuri MP, Brown GG, Meloy MJ, Eberson SC, Kindermann SS, Frank LR, Zorrilla LE, Lohr J. An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder. Psychiatry Res. 2003 Jul 30; 123(3):171-82. PMID: 12928105.
        View in: PubMed
      44. Lohr J, Kuczenski R, Niculescu AB. Oxidative mechanisms and tardive dyskinesia. CNS Drugs. 2003; 17(1):47-62. PMID: 12467492.
        View in: PubMed
      45. Lohr J, Caligiuri MP, Edson R, Lavori P, Adler LA, Rotrosen J, Hitzemann R. Treatment predictors of extrapyramidal side effects in patients with tardive dyskinesia: results from Veterans Affairs Cooperative Study 394. J Clin Psychopharmacol. 2002 Apr; 22(2):196-200. PMID: 11910266.
        View in: PubMed
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