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Willis Li

Title(s)Professor, Medicine
SchoolHealth Sciences
Phone858-534-7824
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    Collapse Biography 
    Collapse Education and Training
    Harvard Medical School, BostonPostdoctoral FellowGenetics
    Columbia University, New YorkPh.D.Biological Sciences
    Peking University, BeijingB.S.Biochemistry
    Collapse Awards and Honors
    Glenn Foundation for Medical Research2011Glenn Award for Research in Biological Mechanisms of Aging
    University of Rochester2008Davey Memorial Award for Outstanding Cancer Research
    Leukemia & Lymphoma Society2007  - 2012Research Scholar Award
    American Cancer Society2006  - 2010Research Scholar Award
    Columbia University1995Peter Sajovic Memorial Prize for Outstanding Graduate Student

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanism of heterochromatin regulation by STAT
    NIH/NIGMS R01GM131044Sep 20, 2018 - Aug 31, 2022
    Role: Principal Investigator
    Unphosphorylated STAT recruits HP1 for gene repression
    NIH/NCI R03CA212727Feb 1, 2017 - Jan 31, 2019
    Role: Principal Investigator
    Request for a Zeiss LSM 710 Confocal Microscope
    NIH/NCRR S10RR026616Jun 24, 2010 - Jun 23, 2011
    Role: Principal Investigator
    Epigenetic tumor induction by heterochromatin instability
    NIH/NCI R01CA131326Jul 1, 2009 - Nov 30, 2014
    Role: Principal Investigator
    Network Interaction between EGFR and TGFbeta Pathways
    NIH/NIGMS R01GM077046Feb 1, 2006 - Jan 31, 2011
    Role: Principal Investigator
    Genetic Analysis of Intracellular Signaling Crosstalk
    NIH/NIGMS R01GM065774Apr 1, 2002 - Mar 31, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Magat JM, Thomas JL, Dumouchel JP, Murray F, Li WX, Li J. Endogenous IL-33 and Its Autoamplification of IL-33/ST2 Pathway Play an Important Role in Asthma. J Immunol. 2020 Jan 27. PMID: 31988179.
      View in: PubMed
    2. Loyola AC, Zhang L, Shang R, Dutta P, Li J, Li WX. Identification of methotrexate as a heterochromatin-promoting drug. Sci Rep. 2019 Aug 12; 9(1):11673. PMID: 31406262.
      View in: PubMed
    3. Tsurumi A, Xue S, Zhang L, Li J, Li WX. Genome-wide Kdm4 histone demethylase transcriptional regulation in Drosophila. Mol Genet Genomics. 2019 Oct; 294(5):1107-1121. PMID: 31020413.
      View in: PubMed
    4. Zhang H, Dutta P, Liu J, Sabri N, Song Y, Li WX, Li J. Tumour cell-intrinsic CTLA4 regulates PD-L1 expression in non-small cell lung cancer. J Cell Mol Med. 2019 01; 23(1):535-542. PMID: 30378264.
      View in: PubMed
    5. Tsurumi A, Zhao C, Li WX. Canonical and non-canonical JAK/STAT transcriptional targets may be involved in distinct and overlapping cellular processes. BMC Genomics. 2017 Sep 11; 18(1):718. PMID: 28893190.
      View in: PubMed
    6. Dutta P, Li WX. The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression. PLoS One. 2017; 12(6):e0180026. PMID: 28665982.
      View in: PubMed
    7. Xing Y, Li WX. Heterochromatin components in germline stem cell maintenance. Sci Rep. 2015 Dec 02; 5:17463. PMID: 26626305.
      View in: PubMed
    8. Li J, Li WX, Bai C, Song Y. Particulate matter-induced epigenetic changes and lung cancer. Clin Respir J. 2017 Sep; 11(5):539-546. PMID: 26403658.
      View in: PubMed
    9. Dutta P, Sabri N, Li J, Li WX. Role of STAT3 in lung cancer. JAKSTAT. 2014; 3(4):e999503. PMID: 26413424.
      View in: PubMed
    10. Lim SJ, Scott A, Xiong XP, Vahidpour S, Karijolich J, Guo D, Pei S, Yu YT, Zhou R, Li WX. Requirement for CRIF1 in RNA interference and Dicer-2 stability. RNA Biol. 2014; 11(9):1171-9. PMID: 25483042.
      View in: PubMed
    11. Tsurumi A, Dutta P, Dutta P, Shang R, Yan SJ, Sheng R, Li WX. Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling. Sci Rep. 2013 Oct 08; 3:2894. PMID: 24100631.
      View in: PubMed
    12. Silver-Morse L, Li WX. JAK-STAT in heterochromatin and genome stability. JAKSTAT. 2013 Jul 01; 2(3):e26090. PMID: 24069569.
      View in: PubMed
    13. Hu X, Dutta P, Tsurumi A, Li J, Wang J, Land H, Li WX. Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):10213-8. PMID: 23733954.
      View in: PubMed
    14. Gaur K, Li J, Wang D, Dutta P, Yan SJ, Tsurumi A, Land H, Wu G, Li WX. The Birt-Hogg-Dubé tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis. Hum Mol Genet. 2013 Jan 15; 22(2):284-99. PMID: 23077212.
      View in: PubMed
    15. Tsurumi A, Li WX. Global heterochromatin loss: a unifying theory of aging? Epigenetics. 2012 Jul; 7(7):680-8. PMID: 22647267.
      View in: PubMed
    16. Larson K, Yan SJ, Tsurumi A, Liu J, Zhou J, Gaur K, Guo D, Eickbush TH, Li WX. Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. PLoS Genet. 2012 Jan; 8(1):e1002473. PMID: 22291607.
      View in: PubMed
    17. Ting HJ, Yasmin-Karim S, Yan SJ, Hsu JW, Lin TH, Zeng W, Messing J, Sheu TJ, Bao BY, Li WX, Messing E, Lee YF. A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D. Cancer Res. 2012 Feb 15; 72(4):958-68. PMID: 22207345.
      View in: PubMed
    18. Tsurumi A, Xia F, Li J, Larson K, LaFrance R, Li WX. STAT is an essential activator of the zygotic genome in the early Drosophila embryo. PLoS Genet. 2011 May; 7(5):e1002086. PMID: 21637778.
      View in: PubMed
    19. Silver-Morse L, Li WX. The role of receptor tyrosine kinases in primordial germ cell migration. Methods Mol Biol. 2011; 750:291-306. PMID: 21618099.
      View in: PubMed
    20. Yan SJ, Li WX. Using Drosophila larval imaginal discs to study low-dose radiation-induced cell cycle arrest. Methods Mol Biol. 2011; 782:93-103. PMID: 21870287.
      View in: PubMed
    21. Yan SJ, Lim SJ, Shi S, Dutta P, Li WX. Unphosphorylated STAT and heterochromatin protect genome stability. FASEB J. 2011 Jan; 25(1):232-41. PMID: 20847228.
      View in: PubMed
    22. Yan SJ, Zartman JJ, Zhang M, Scott A, Shvartsman SY, Li WX. Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation. Mol Syst Biol. 2009; 5:278. PMID: 19536201.
      View in: PubMed
    23. Li WX. Canonical and non-canonical JAK-STAT signaling. Trends Cell Biol. 2008 Nov; 18(11):545-51. PMID: 18848449.
      View in: PubMed
    24. Xia F, Li J, Hickey GW, Tsurumi A, Larson K, Guo D, Yan SJ, Silver-Morse L, Li WX. Raf activation is regulated by tyrosine 510 phosphorylation in Drosophila. PLoS Biol. 2008 May 20; 6(5):e128. PMID: 18494562.
      View in: PubMed
    25. Shi S, Larson K, Guo D, Lim SJ, Dutta P, Yan SJ, Li WX. Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability. Nat Cell Biol. 2008 Apr; 10(4):489-96. PMID: 18344984.
      View in: PubMed
    26. Xing Y, Shi S, Le L, Lee CA, Silver-Morse L, Li WX. Evidence for transgenerational transmission of epigenetic tumor susceptibility in Drosophila. PLoS Genet. 2007 Sep; 3(9):1598-606. PMID: 17845077.
      View in: PubMed
    27. Li J, Li WX. A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradation. Nat Cell Biol. 2006 Dec; 8(12):1407-14. PMID: 17115029.
      View in: PubMed
    28. Mogila V, Xia F, Li WX. An intrinsic cell cycle checkpoint pathway mediated by MEK and ERK in Drosophila. Dev Cell. 2006 Oct; 11(4):575-82. PMID: 17011495.
      View in: PubMed
    29. Shi S, Calhoun HC, Xia F, Li J, Le L, Li WX. JAK signaling globally counteracts heterochromatic gene silencing. Nat Genet. 2006 Sep; 38(9):1071-6. PMID: 16892059.
      View in: PubMed
    30. Li J, Li WX, Gelbart WM. A genetic screen for maternal-effect suppressors of decapentaplegic identifies the eukaryotic translation initiation factor 4A in Drosophila. Genetics. 2005 Dec; 171(4):1629-41. PMID: 15972466.
      View in: PubMed
    31. Li WX. Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development. Dev Dyn. 2005 Mar; 232(3):656-72. PMID: 15704136.
      View in: PubMed
    32. Li WX. Receptor tyrosine kinase signaling and primordial germ cell development. Cell Cycle. 2004 Mar; 3(3):249-51. PMID: 14726648.
      View in: PubMed
    33. Yan SJ, Gu Y, Li WX, Fleming RJ. Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development. Development. 2004 Jan; 131(2):285-98. PMID: 14701680.
      View in: PubMed
    34. Li J, Li W, Calhoun HC, Xia F, Gao FB, Li WX. Patterns and functions of STAT activation during Drosophila embryogenesis. Mech Dev. 2003 Dec; 120(12):1455-68. PMID: 14654218.
      View in: PubMed
    35. Li J, Xia F, Li WX. Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila. Dev Cell. 2003 Nov; 5(5):787-98. PMID: 14602078.
      View in: PubMed
    36. Li J, Li WX. Drosophila gain-of-function mutant RTK torso triggers ectopic Dpp and STAT signaling. Genetics. 2003 May; 164(1):247-58. PMID: 12750336.
      View in: PubMed
    37. Li WX, Agaisse H, Mathey-Prevot B, Perrimon N. Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila. Development. 2002 Sep; 129(18):4241-8. PMID: 12183376.
      View in: PubMed
    38. Li W, Noll E, Perrimon N. Identification of autosomal regions involved in Drosophila Raf function. Genetics. 2000 Oct; 156(2):763-74. PMID: 11014822.
      View in: PubMed
    39. Baum B, Li W, Perrimon N. A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. Curr Biol. 2000 Aug 24; 10(16):964-73. PMID: 10985383.
      View in: PubMed
    40. Li W, Melnick M, Perrimon N. Dual function of Ras in Raf activation. Development. 1998 Dec; 125(24):4999-5008. PMID: 9811584.
      View in: PubMed
    41. Li W, Skoulakis EM, Davis RL, Perrimon N. The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras 1-dependent manner. Development. 1997 Oct; 124(20):4163-71. PMID: 9374412.
      View in: PubMed
    42. Li W, Perrimon N. Specificity of receptor tyrosine kinase signaling pathways: lessons from Drosophila. Genet Eng (N Y). 1997; 19:167-82. PMID: 9193108.
      View in: PubMed
    43. Li W, Tully T, Kalderon D. Effects of a conditional Drosophila PKA mutant on olfactory learning and memory. Learn Mem. 1996 Jan-Feb; 2(6):320-33. PMID: 10467582.
      View in: PubMed
    44. Meléndez A, Li W, Kalderon D. Activity, expression and function of a second Drosophila protein kinase A catalytic subunit gene. Genetics. 1995 Dec; 141(4):1507-20. PMID: 8601490.
      View in: PubMed
    45. Li W, Ohlmeyer JT, Lane ME, Kalderon D. Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell. 1995 Feb 24; 80(4):553-62. PMID: 7867063.
      View in: PubMed
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