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    Willis Li

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0716
    CA La Jolla 92093
    Phone858-534-7824
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Harvard Medical School, BostonPostdoctoral FellowGenetics
      Columbia University, New YorkPh.D.Biological Sciences
      Peking University, BeijingB.S.Biochemistry
      Collapse Awards and Honors
      Glenn Foundation for Medical Research2011Glenn Award for Research in Biological Mechanisms of Aging
      University of Rochester2008Davey Memorial Award for Outstanding Cancer Research
      Leukemia & Lymphoma Society2007  - 2012Research Scholar Award
      American Cancer Society2006  - 2010Research Scholar Award
      Columbia University1995Peter Sajovic Memorial Prize for Outstanding Graduate Student

      Collapse Overview 

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Tsurumi A, Zhao C, Li W. Canonical and non-canonical JAK/STAT transcriptional targets may be involved in distinct and overlapping cellular processes. BMC Genomics. 2017 Sep 11; 18(1):718. PMID: 28893190.
        View in: PubMed
      2. Dutta P, Li W. The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression. PLoS One. 2017; 12(6):e0180026. PMID: 28665982.
        View in: PubMed
      3. Xing Y, Li W. Heterochromatin components in germline stem cell maintenance. Sci Rep. 2015 Dec 02; 5:17463. PMID: 26626305; PMCID: PMC4667240.
      4. Li J, Li W, Bai C, Song Y. Particulate matter-induced epigenetic changes and lung cancer. Clin Respir J. 2017 Sep; 11(5):539-546. PMID: 26403658.
        View in: PubMed
      5. Dutta P, Sabri N, Li J, Li W. Role of STAT3 in lung cancer. JAKSTAT. 2014; 3(4):e999503. PMID: 26413424; PMCID: PMC4580090.
      6. Lim SJ, Scott A, Xiong XP, Vahidpour S, Karijolich J, Guo D, Pei S, Yu YT, Zhou R, Li W. Requirement for CRIF1 in RNA interference and Dicer-2 stability. RNA Biol. 2014; 11(9):1171-9. PMID: 25483042; PMCID: PMC4615304.
      7. Tsurumi A, Dutta P, Dutta P, Shang R, Yan SJ, Sheng R, Li W. Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling. Sci Rep. 2013 Oct 08; 3:2894. PMID: 24100631; PMCID: PMC3792421.
      8. Silver-Morse L, Li W. JAK-STAT in heterochromatin and genome stability. JAKSTAT. 2013 Jul 01; 2(3):e26090. PMID: 24069569; PMCID: PMC3772121.
      9. Hu X, Dutta P, Tsurumi A, Li J, Wang J, Land H, Li W. Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):10213-8. PMID: 23733954; PMCID: PMC3690839.
      10. Gaur K, Li J, Wang D, Dutta P, Yan SJ, Tsurumi A, Land H, Wu G, Li W. The Birt-Hogg-Dubé tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis. Hum Mol Genet. 2013 Jan 15; 22(2):284-99. PMID: 23077212; PMCID: PMC3526160.
      11. Tsurumi A, Li W. Global heterochromatin loss: a unifying theory of aging? Epigenetics. 2012 Jul; 7(7):680-8. PMID: 22647267; PMCID: PMC3414389.
      12. Larson K, Yan SJ, Tsurumi A, Liu J, Zhou J, Gaur K, Guo D, Eickbush TH, Li W. Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. PLoS Genet. 2012 Jan; 8(1):e1002473. PMID: 22291607; PMCID: PMC3266895.
      13. Ting HJ, Yasmin-Karim S, Yan SJ, Hsu JW, Lin TH, Zeng W, Messing J, Sheu TJ, Bao BY, Li W, Messing E, Lee YF. A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D. Cancer Res. 2012 Feb 15; 72(4):958-68. PMID: 22207345.
        View in: PubMed
      14. Tsurumi A, Xia F, Li J, Larson K, LaFrance R, Li W. STAT is an essential activator of the zygotic genome in the early Drosophila embryo. PLoS Genet. 2011 May; 7(5):e1002086. PMID: 21637778; PMCID: PMC3102735.
      15. Yan SJ, Li W. Using Drosophila larval imaginal discs to study low-dose radiation-induced cell cycle arrest. Methods Mol Biol. 2011; 782:93-103. PMID: 21870287; PMCID: PMC3486928.
      16. Silver-Morse L, Li W. The role of receptor tyrosine kinases in primordial germ cell migration. Methods Mol Biol. 2011; 750:291-306. PMID: 21618099.
        View in: PubMed
      17. Yan SJ, Lim SJ, Shi S, Dutta P, Li W. Unphosphorylated STAT and heterochromatin protect genome stability. FASEB J. 2011 Jan; 25(1):232-41. PMID: 20847228; PMCID: PMC3005427.
      18. Yan SJ, Zartman JJ, Zhang M, Scott A, Shvartsman SY, Li W. Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation. Mol Syst Biol. 2009; 5:278. PMID: 19536201; PMCID: PMC2710866.
      19. Li W. Canonical and non-canonical JAK-STAT signaling. Trends Cell Biol. 2008 Nov; 18(11):545-51. PMID: 18848449; PMCID: PMC3082280.
      20. Xia F, Li J, Hickey GW, Tsurumi A, Larson K, Guo D, Yan SJ, Silver-Morse L, Li W. Raf activation is regulated by tyrosine 510 phosphorylation in Drosophila. PLoS Biol. 2008 May 20; 6(5):e128. PMID: 18494562; PMCID: PMC2386837.
      21. Shi S, Larson K, Guo D, Lim SJ, Dutta P, Yan SJ, Li W. Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability. Nat Cell Biol. 2008 Apr; 10(4):489-96. PMID: 18344984; PMCID: PMC3083919.
      22. Xing Y, Shi S, Le L, Lee CA, Silver-Morse L, Li W. Evidence for transgenerational transmission of epigenetic tumor susceptibility in Drosophila. PLoS Genet. 2007 Sep; 3(9):1598-606. PMID: 17845077; PMCID: PMC1971119.
      23. Li J, Li W. A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradation. Nat Cell Biol. 2006 Dec; 8(12):1407-14. PMID: 17115029; PMCID: PMC3090258.
      24. Mogila V, Xia F, Li W. An intrinsic cell cycle checkpoint pathway mediated by MEK and ERK in Drosophila. Dev Cell. 2006 Oct; 11(4):575-82. PMID: 17011495; PMCID: PMC3095892.
      25. Shi S, Calhoun HC, Xia F, Li J, Le L, Li W. JAK signaling globally counteracts heterochromatic gene silencing. Nat Genet. 2006 Sep; 38(9):1071-6. PMID: 16892059; PMCID: PMC3092431.
      26. Li J, Li W, Gelbart WM. A genetic screen for maternal-effect suppressors of decapentaplegic identifies the eukaryotic translation initiation factor 4A in Drosophila. Genetics. 2005 Dec; 171(4):1629-41. PMID: 15972466; PMCID: PMC1456090.
      27. Li W. Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development. Dev Dyn. 2005 Mar; 232(3):656-72. PMID: 15704136; PMCID: PMC3092428.
      28. Li W. Receptor tyrosine kinase signaling and primordial germ cell development. Cell Cycle. 2004 Mar; 3(3):249-51. PMID: 14726648; PMCID: PMC3090257.
      29. Yan SJ, Gu Y, Li W, Fleming RJ. Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development. Development. 2004 Jan; 131(2):285-98. PMID: 14701680.
        View in: PubMed
      30. Li J, Li W, Calhoun HC, Xia F, Gao FB, Li W. Patterns and functions of STAT activation during Drosophila embryogenesis. Mech Dev. 2003 Dec; 120(12):1455-68. PMID: 14654218; PMCID: PMC3090291.
      31. Li J, Xia F, Li W. Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila. Dev Cell. 2003 Nov; 5(5):787-98. PMID: 14602078; PMCID: PMC3092433.
      32. Li J, Li W. Drosophila gain-of-function mutant RTK torso triggers ectopic Dpp and STAT signaling. Genetics. 2003 May; 164(1):247-58. PMID: 12750336; PMCID: PMC1462547.
      33. Li W, Agaisse H, Mathey-Prevot B, Perrimon N. Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila. Development. 2002 Sep; 129(18):4241-8. PMID: 12183376; PMCID: PMC3090254.
      34. Li W, Noll E, Perrimon N. Identification of autosomal regions involved in Drosophila Raf function. Genetics. 2000 Oct; 156(2):763-74. PMID: 11014822; PMCID: PMC1461272.
      35. Baum B, Li W, Perrimon N. A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. Curr Biol. 2000 Aug 24; 10(16):964-73. PMID: 10985383.
        View in: PubMed
      36. Li W, Melnick M, Perrimon N. Dual function of Ras in Raf activation. Development. 1998 Dec; 125(24):4999-5008. PMID: 9811584.
        View in: PubMed
      37. Li W, Skoulakis EM, Davis RL, Perrimon N. The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras 1-dependent manner. Development. 1997 Oct; 124(20):4163-71. PMID: 9374412.
        View in: PubMed
      38. Li W, Perrimon N. Specificity of receptor tyrosine kinase signaling pathways: lessons from Drosophila. Genet Eng (N Y). 1997; 19:167-82. PMID: 9193108.
        View in: PubMed
      39. Li W, Tully T, Kalderon D. Effects of a conditional Drosophila PKA mutant on olfactory learning and memory. Learn Mem. 1996 Jan-Feb; 2(6):320-33. PMID: 10467582.
        View in: PubMed
      40. Meléndez A, Li W, Kalderon D. Activity, expression and function of a second Drosophila protein kinase A catalytic subunit gene. Genetics. 1995 Dec; 141(4):1507-20. PMID: 8601490; PMCID: PMC1206883.
      41. Li W, Ohlmeyer JT, Lane ME, Kalderon D. Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell. 1995 Feb 24; 80(4):553-62. PMID: 7867063.
        View in: PubMed