Todd Costantini

Title(s)Associate Professor, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Todd W. Costantini, MD is currently an Associate Professor of Surgery in the Division of Trauma, Surgical Critical Care, and Burns at the University of California, San Diego and the Trauma Medical Director at UC San Diego. Dr. Costantini is a graduate of the University of Minnesota Medical School. He completed his General Surgery residency at UC-San Diego and went on to complete a fellowship in Trauma and Surgical Critical Care at UC-San Diego under the direction of Dr. Raul Coimbra.
    Dr. Costantini is an investigator in the UC San Diego Laboratories of Trauma, Surgical Critical Care and Burn Research. Dr. Costantini’s basic science research focuses on the neural control of inflammation after severe injury. Dr. Costantini was previously awarded research fellowships by the American Association for the Surgery of Trauma (AAST), the American College of Surgeons, and the American Surgical Association. Dr. Costantini is the principal investigator on an NIH R01 research program focused on the ability of the uniquely human gene CHRFAM7A to contribute to human variability in the anti-inflammatory response to inflammation and injury. His clinical research interests include improving DVT prophylaxis in Trauma and Surgery patients and the study of complex pelvic fracture management. Dr. Costantini currently serves as the Chair of the Multi-institutional Trials Committee for the AAST. He also serves on the research council of the Coalition for National Trauma Research (CNTR) and the research committee of the American College of Surgeons Committee on Trauma.

    Collapse Research 
    Collapse Research Activities and Funding
    2021 Consensus Conference to Implement Optimal VTE Prophylaxis in Trauma
    NIH R13HL158206Jun 22, 2021 - May 31, 2022
    Role: Principal Investigator
    The Human-Specific Gene CHRFAM7A in Leukocytes
    NIH R01GM121530Apr 1, 2017 - Mar 31, 2022
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Does Gender Matter: A Multi-Institutional Analysis of Viscoelastic Profiles for 1565 Trauma Patients With Severe Hemorrhage. Am Surg. 2021 Jul 15; 31348211033542. Smith A, Duchesne J, Marturano M, Lawicki S, Sexton K, Taylor JR, Richards J, Harris C, Moreno-Ponte O, Cannon JW, Guzman JF, Pickett ML, Cripps MW, Curry T, Costantini T, Guidry C. PMID: 34266290.
      View in: PubMed   Mentions:    Fields:    
    2. Methamphetamine Use is Associated with Increased Surgical Site Infections after Trauma Laparotomy. J Surg Res. 2021 Jul 11; 267:563-567. Weaver JL, Berndtson AE, Lee J, Kobayashi L, Doucet J, Godat L, Costantini TW, Higginson S. PMID: 34261007.
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    3. Pelvic Fracture-Related Hypotension: A Review of Contemporary Adjuncts for Hemorrhage Control. J Trauma Acute Care Surg. 2021 Jul 06. DuBose JJ, Burlew CC, Joseph B, Keville M, Harfouche M, Morrison J, Fox CJ, Mooney J, O'Toole R, Slobogean G, Marchand LS, Demetriades D, Werner NL, Benjamin E, Costantini T. PMID: 34238857.
      View in: PubMed   Mentions:    Fields:    
    4. Drug and alcohol positivity of traumatically injured patients related to COVID-19 stay-at-home orders. Am J Drug Alcohol Abuse. 2021 Jun 04; 1-7. Young KN, Yeates EO, Grigorian A, Schellenberg M, Owattanapanich N, Barmparas G, Margulies D, Juillard C, Garber K, Cryer H, Tillou A, Burruss S, Penaloza-Villalobos L, Lin A, Figueras RA, Brenner M, Firek C, Costantini T, Santorelli J, Curry T, Wintz D, Biffl WL, Schaffer KB, Duncan TK, Barbaro C, Diaz G, Johnson A, Chinn J, Naaseh A, Leung A, Grabar C, Nahmias J. PMID: 34087086.
      View in: PubMed   Mentions: 1     Fields:    
    5. COVID-19 in trauma: a propensity-matched analysis of COVID and non-COVID trauma patients. Eur J Trauma Emerg Surg. 2021 May 25. Yeates EO, Grigorian A, Schellenberg M, Owattanapanich N, Barmparas G, Margulies D, Juillard C, Garber K, Cryer H, Tillou A, Burruss S, Figueras RA, Mladenov G, Brenner M, Firek C, Costantini T, Santorelli J, Curry T, Wintz D, Biffl WL, Schaffer KB, Duncan TK, Barbaro C, Diaz G, Johnson A, Chinn J, Naaseh A, Leung A, Grabar C, Nahmias J. PMID: 34031703.
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    6. A Tale of Two Centers: Is Low-Molecular-Weight Heparin Really Superior for Prevention of Post-Traumatic Venous Thromboembolism? J Trauma Acute Care Surg. 2021 Apr 24. Checchi KD, Costantini TW, Badiee J, Berndtson AE, Calvo RY, Rooney AS, Wessels LE, Prieto JM, Sise CB, Sise MJ, Martin MJ, Bansal V. PMID: 33901051.
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    7. Restart TICrH: An Adaptive Randomized Trial of Time Intervals to Restart Direct Oral Anticoagulants after Traumatic Intracranial Hemorrhage. J Neurotrauma. 2021 Jun 01; 38(13):1791-1798. Milling TJ, Warach S, Johnston SC, Gajewski B, Costantini T, Price M, Wick J, Roward S, Mudaranthakam D, Dula AN, King B, Muddiman A, Lip GYH. PMID: 33470152.
      View in: PubMed   Mentions:    Fields:    
    8. Changes in traumatic mechanisms of injury in Southern California related to COVID-19: Penetrating trauma as a second pandemic. J Trauma Acute Care Surg. 2021 04 01; 90(4):714-721. Yeates EO, Grigorian A, Barrios C, Schellenberg M, Owattanapanich N, Barmparas G, Margulies D, Juillard C, Garber K, Cryer H, Tillou A, Burruss S, Penaloza-Villalobos L, Lin A, Figueras RA, Brenner M, Firek C, Costantini T, Santorelli J, Curry T, Wintz D, Biffl WL, Schaffer KB, Duncan TK, Barbaro C, Diaz G, Johnson A, Chinn J, Naaseh A, Leung A, Grabar C, Nahmias J. PMID: 33395031.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    9. Enhancing trauma registries by integrating traffic records and geospatial analysis to improve bicyclist safety. J Trauma Acute Care Surg. 2021 04 01; 90(4):631-640. Doucet JJ, Godat LN, Kobayashi L, Berndtson AE, Liepert AE, Raschke E, Denny JW, Weaver J, Smith A, Costantini T. PMID: 33443983.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Repeat head computed tomography for anticoagulated patients with an initial negative scan is not cost-effective. Surgery. 2021 Mar 26. Borst J, Godat LN, Berndtson AE, Kobayashi L, Doucet JJ, Costantini TW. PMID: 33781587.
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    11. The coronavirus disease 2019 (COVID-19) stay-at-home order's unequal effects on trauma volume by insurance status in Southern California. Surgery. 2021 Mar 05. Yeates EO, Juillard C, Grigorian A, Schellenberg M, Owattanapanich N, Barmparas G, Margulies D, Garber K, Cryer H, Tillou A, Burruss S, Penaloza-Villalobos L, Lin A, Figueras RA, Brenner M, Firek C, Costantini T, Santorelli J, Curry T, Wintz D, Biffl WL, Schaffer KB, Duncan TK, Barbaro C, Diaz G, Johnson A, Chinn J, Naaseh A, Leung A, Grabar C, Yeates TO, Nahmias J. PMID: 33849732.
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    12. Restarting and timing of oral anticoagulation after traumatic intracranial hemorrhage: a review and summary of ongoing and planned prospective randomized clinical trials. Trauma Surg Acute Care Open. 2020; 5(1):e000605. King B, Milling T, Gajewski B, Costantini TW, Wick J, Price MA, Mudaranthakam D, Stein DM, Connolly S, Valadka A, Warach S. PMID: 33313417.
      View in: PubMed   Mentions:
    13. Emergency General Surgery and the Gallbladder: The Affordable Care Act's Impact on Practice Patterns. J Surg Res. 2021 01; 257:356-362. Godat LN, Costantini TW, Doucet JJ. PMID: 32892131.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. CHRFAM7A reduces monocyte/macrophage migration and colony formation in vitro. Inflamm Res. 2020 Jul; 69(7):631-633. Chan TW, Langness S, Cohen O, Eliceiri BP, Baird A, Costantini TW. PMID: 32303780.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. ECRG4 regulates neutrophil recruitment and CD44 expression during the inflammatory response to injury. Sci Adv. 2020 03; 6(11):eaay0518. Dorschner RA, Lee J, Cohen O, Costantini T, Baird A, Eliceiri BP. PMID: 32195341.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    16. The Effects of Cross-Border Transport on Patients With Tibia Fractures. J Surg Res. 2020 05; 249:91-98. Brito A, Godat LN, Costantini TW, Smith AM, Doucet JJ, Berndtson AE. PMID: 31926401.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Electrical stimulation of the vagus nerve improves intestinal blood flow after trauma and hemorrhagic shock. Surgery. 2020 03; 167(3):638-645. Yagi M, Morishita K, Ueno A, Nakamura H, Akabori H, Senda A, Kojima M, Aiboshi J, Costantini T, Coimbra R, Otomo Y. PMID: 31759624.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    18. Outcomes in patients with gunshot wounds to the brain. Trauma Surg Acute Care Open. 2019; 4(1):e000351. Robinson LA, Turco LM, Robinson B, Corsa JG, Mount M, Hamrick AV, Berne J, Mederos DR, McNickle AG, Chestovich PJ, Weinberger J, Grigorian A, Nahmias J, Lee JK, Chow KL, Olson EJ, Pascual JL, Solomon R, Pigneri DA, Ladhani HA, Fraifogl J, Claridge J, Curry T, Costantini TW, Kongwibulwut M, Kaafarani H, San Roman J, Schreiber C, Goldenberg-Sandau A, Hu P, Bosarge P, Uhlich R, Lunardi N, Usmani F, Sakran JV, Babcock JM, Quispe JC, Lottenberg L, Cabral D, Chang G, Gulmatico J, Parks JJ, Rattan R, Massetti J, Gurney O, Bruns B, Smith AA, Guidry C, Kutcher ME, Logan MS, Kincaid MY, Spalding C, Noorbaksh M, Philp FH, Cragun B, Winfield RD. PMID: 31799416.
      View in: PubMed   Mentions:
    19. Risk Factors for Urinary Tract Infection or Pneumonia After Admission for Traumatic Subdural Hematoma at a Level I Trauma Center: Large Single-Institution Series. World Neurosurg. 2020 Feb; 134:e754-e760. Pham TB, Srinivas S, Martin JR, Brandel MG, Wali AR, Rennert RC, Steinberg JA, Santiago-Dieppa DR, Costantini TW, Khalessi AA. PMID: 31712113.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Ultrasound-guided percutaneous intercostal nerve cryoneurolysis for analgesia following traumatic rib fracture -a case series. Korean J Anesthesiol. 2020 10; 73(5):455-459. Finneran Iv JJ, Gabriel RA, Swisher MW, Berndtson AE, Godat LN, Costantini TW, Ilfeld BM. PMID: 31684715.
      View in: PubMed   Mentions: 2     Fields:    
    21. Who's being left behind? Uninsured emergency general surgery admissions after the ACA. Am J Surg. 2019 12; 218(6):1102-1109. Albini PT, Cochran-Yu MR, Godat LN, Costantini TW, Doucet JJ. PMID: 31607385.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. A Platform to Study the Effects of Electrical Stimulation on Immune Cell Activation During Wound Healing. Adv Biosyst. 2019 10; 3(10):e1900106. Wang K, Parekh U, Ting JK, Yamamoto NAD, Zhu J, Costantini T, Arias AC, Eliceiri BP, Ng TN. PMID: 32648726.
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    23. Readmissions After Acute Hospitalization for Traumatic Brain Injury. J Surg Res. 2019 12; 244:332-337. Brito A, Costantini TW, Berndtson AE, Smith A, Doucet JJ, Godat LN. PMID: 31306890.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. The effect of hemorrhage control adjuncts on outcome in severe pelvic fracture: A multi-institutional study. J Trauma Acute Care Surg. 2019 Jul; 87(1):117-124. Duchesne J, Costantini TW, Khan M, Taub E, Rhee P, Morse B, Namias N, Schwarz A, Graves J, Kim DY, Howell E, Sperry J, Anto V, Winfield RD, Schreiber M, Behrens B, Martinez B, Raza S, Seamon M, Tatum D. PMID: 31260426.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    25. Respect your elders: effects of ageing on intracranial pressure monitor use in traumatic brain injury. Trauma Surg Acute Care Open. 2019; 4(1):e000306. Schupper AJ, Berndtson AE, Smith A, Godat L, Costantini TW. PMID: 31321312.
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    26. Open reading frame mining identifies a TLR4 binding domain in the primary sequence of ECRG4. Cell Mol Life Sci. 2019 Dec; 76(24):5027-5039. Dang X, Coimbra R, Mao L, Podvin S, Li X, Yu H, Costantini TW, Zeng X, Larocca D, Eliceiri BP, Baird A. PMID: 31190084.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    27. Cross-border antibiotic resistance patterns in trauma patients. Surgery. 2019 07; 166(1):109-115. Berndtson AE, Bricker-Ford R, Box K, Madsen GZ, Malany L, Smith AM, Costantini TW, Coimbra R. PMID: 31072667.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response. Proc Natl Acad Sci U S A. 2019 04 16; 116(16):7932-7940. Costantini TW, Chan TW, Cohen O, Langness S, Treadwell S, Williams E, Eliceiri BP, Baird A. PMID: 30944217.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    29. Anti-Xa guided enoxaparin dose adjustment improves pharmacologic deep venous thrombosis prophylaxis in burn patients. Burns. 2019 06; 45(4):818-824. Cronin BJ, Godat LN, Berndtson AE, Pham A, Kolan S, Box K, Lee JG, Costantini TW. PMID: 30827851.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. TBC1D3 regulates the payload and biological activity of extracellular vesicles that mediate tissue repair. FASEB J. 2019 05; 33(5):6129-6139. Qin S, Dorschner RA, Masini I, Lavoie-Gagne O, Stahl PD, Costantini TW, Baird A, Eliceiri BP. PMID: 30715917.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    31. Precious cargo: Modulation of the mesenteric lymph exosome payload after hemorrhagic shock. J Trauma Acute Care Surg. 2019 01; 86(1):52-61. Williams EC, Coimbra R, Chan TW, Baird A, Eliceiri BP, Costantini TW. PMID: 30576304.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    32. Impact of the Affordable Care Act on elective general surgery clinical practice. Am J Surg. 2019 06; 217(6):1055-1059. Yuen L, Costantini TW, Coimbra R, Godat LN. PMID: 30448210.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. Risk Factors for Venous Thromboembolism After Admission for Traumatic Subdural Hematoma at Level I Trauma Center: Large Single-Institution Series. World Neurosurg. 2019 02; 122:e619-e626. Rennert RC, Martin JR, Brandel MG, Steinberg JA, Santiago-Dieppa DR, Wali AR, Costantini TW, Khalessi AA. PMID: 31108078.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. CHRFAM7A alters binding to the neuronal alpha-7 nicotinic acetylcholine receptor. Neurosci Lett. 2019 01 18; 690:126-131. Chan T, Williams E, Cohen O, Eliceiri BP, Baird A, Costantini TW. PMID: 30308236.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    35. Implementation of a National Trauma Research Action Plan (NTRAP). J Trauma Acute Care Surg. 2018 06; 84(6):1012-1016. Bulger EM, Rasmussen TE, Jurkovich GJ, Fabian TC, Kozar RA, Coimbra R, Costantini TW, Ficke J, Malhotra AK, Price MA, Smith SL, Cioffi WG, Stewart RM. PMID: 29370052.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. The Use of Solicited Publishing by Academic Surgeons. Surgery. 2018 08; 164(2):212-218. Nguyen V, Marmor RA, Ramamoorthy SL, Costantini TW, Baumgartner JM, Berumen J, Jacobsen GR, Sicklick JK. PMID: 29724409.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. Gut epithelial cell-derived exosomes trigger posttrauma immune dysfunction. J Trauma Acute Care Surg. 2018 02; 84(2):257-264. Kojima M, Costantini TW, Eliceiri BP, Chan TW, Baird A, Coimbra R. PMID: 29194317.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    38. Prophylactic enoxaparin doses may be inadequate in patients undergoing abdominal cancer surgery. J Surg Res. 2018 01; 221:183-189. Baumgartner JM, McKenzie S, Block S, Costantini TW, Lowy AM. PMID: 29229126.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    39. Exosomes in postshock mesenteric lymph are key mediators of acute lung injury triggering the macrophage activation via Toll-like receptor 4. FASEB J. 2018 01; 32(1):97-110. Kojima M, Gimenes-Junior JA, Chan TW, Eliceiri BP, Baird A, Costantini TW, Coimbra R. PMID: 28855278.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    40. Pelvic fracture pattern predicts the need for hemorrhage control intervention-Results of an AAST multi-institutional study. J Trauma Acute Care Surg. 2017 06; 82(6):1030-1038. Costantini TW, Coimbra R, Holcomb JB, Podbielski JM, Catalano RD, Blackburn A, Scalea TM, Stein DM, Williams L, Conflitti J, Keeney S, Hoey C, Zhou T, Sperry J, Skiada D, Inaba K, Williams BH, Minei JP, Privette A, Mackersie RC, Robinson BR, Moore FO, AAST Pelvic Fracture Study Group . PMID: 28520685.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    41. Analysis of Surfing Injuries Presenting in the Acute Trauma Setting. Ann Plast Surg. 2017 May; 78(5 Suppl 4):S233-S237. Jubbal KT, Chen C, Costantini T, Herrera F, Dobke M, Suliman A. PMID: 28301362.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    42. Enteric glia cells are critical to limiting the intestinal inflammatory response after injury. Am J Physiol Gastrointest Liver Physiol. 2017 Mar 01; 312(3):G274-G282. Langness S, Kojima M, Coimbra R, Eliceiri BP, Costantini TW. PMID: 28082286.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    43. Exosomes, not protein or lipids, in mesenteric lymph activate inflammation: Unlocking the mystery of post-shock multiple organ failure. J Trauma Acute Care Surg. 2017 01; 82(1):42-50. Kojima M, Gimenes-Junior JA, Langness S, Morishita K, Lavoie-Gagne O, Eliceiri B, Costantini TW, Coimbra R. PMID: 27779585.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    44. Modulating the Biologic Activity of Mesenteric Lymph after Traumatic Shock Decreases Systemic Inflammation and End Organ Injury. PLoS One. 2016; 11(12):e0168322. Langness S, Costantini TW, Morishita K, Eliceiri BP, Coimbra R. PMID: 27977787.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    45. If some is good, more is better: An enoxaparin dosing strategy to improve pharmacologic venous thromboembolism prophylaxis. J Trauma Acute Care Surg. 2016 12; 81(6):1095-1100. Berndtson AE, Costantini TW, Lane J, Box K, Coimbra R. PMID: 27244575.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    46. Mice engrafted with human hematopoietic stem cells support a human myeloid cell inflammatory response in vivo. Wound Repair Regen. 2016 11; 24(6):1004-1014. Baird A, Deng C, Eliceiri MH, Haghi F, Dang X, Coimbra R, Costantini TW, Torbett BE, Eliceiri BP. PMID: 27663454.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    47. Does sex matter? Effects on venous thromboembolism risk in screened trauma patients. J Trauma Acute Care Surg. 2016 09; 81(3):493-9. Berndtson AE, Costantini TW, Smith AM, Kobayashi L, Coimbra R. PMID: 27280942.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    48. Lost your nerve? Modulating the parasympathetic nervous system to treat inflammatory bowel disease. J Physiol. 2016 08 01; 594(15):4097-8. Costantini TW, Baird A. PMID: 27477606.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    49. Abdominal vascular trauma. Trauma Surg Acute Care Open. 2016; 1(1):e000015. Kobayashi LM, Costantini TW, Hamel MG, Dierksheide JE, Coimbra R. PMID: 29766059.
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    50. Isolated traumatic brain injury in patients with cirrhosis: do different treatment paradigms result in increased mortality? Am J Surg. 2017 Jan; 213(1):80-86. Langness S, Costantini TW, Smith A, Bansal V, Coimbra R. PMID: 27421188.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    51. Current management of hemorrhage from severe pelvic fractures: Results of an American Association for the Surgery of Trauma multi-institutional trial. J Trauma Acute Care Surg. 2016 May; 80(5):717-23; discussion 723-5. Costantini TW, Coimbra R, Holcomb JB, Podbielski JM, Catalano R, Blackburn A, Scalea TM, Stein DM, Williams L, Conflitti J, Keeney S, Suleiman G, Zhou T, Sperry J, Skiada D, Inaba K, Williams BH, Minei JP, Privette A, Mackersie RC, Robinson BR, Moore FO, AAST Pelvic Fracture Study Group . PMID: 26958799.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    52. Injury, inflammation and the emergence of human-specific genes. Wound Repair Regen. 2016 05; 24(3):602-6. Baird A, Costantini T, Coimbra R, Eliceiri BP. PMID: 26874655.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    53. Up-regulation of the human-specific CHRFAM7A gene in inflammatory bowel disease. BBA Clin. 2016 Jun; 5:66-71. Baird A, Coimbra R, Dang X, Eliceiri BP, Costantini TW. PMID: 27051591.
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    54. The Response to Burn Injury in Mice With Human Hematolymphoid Systems. Ann Surg. 2016 Jan; 263(1):199-204. Costantini TW, Meads M, Dang X, Coimbra R, Torbett BE, Baird A, Eliceiri BP. PMID: 25575256.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    55. Complexities of the Enteric Nervous System: In Reply to Fujita. J Am Coll Surg. 2016 Jan; 222(1):105-6. Langness S, Coimbra R, Costantini T. PMID: 26721758.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    56. Monitoring Neutrophil-Expressed Cell Surface Esophageal Cancer Related Gene-4 after Severe Burn Injury. Surg Infect (Larchmt). 2015 Dec; 16(6):669-74. Costantini TW, Coimbra R, Lopez NE, Lee JG, Potenza B, Smith A, Baird A, Eliceiri BP. PMID: 26460850.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    57. Vagus Nerve Mediates the Neural Stem Cell Response to Intestinal Injury. J Am Coll Surg. 2015 Oct; 221(4):871-9. Langness S, Coimbra R, Eliceiri BP, Costantini TW. PMID: 26209457.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    58. Neuroenteric axis modulates the balance of regulatory T cells and T-helper 17 cells in the mesenteric lymph node following trauma/hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 01; 309(3):G202-8. Morishita K, Coimbra R, Langness S, Eliceiri BP, Costantini TW. PMID: 26045612.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    59. A Human-Specific a7-Nicotinic Acetylcholine Receptor Gene in Human Leukocytes: Identification, Regulation and the Consequences of CHRFAM7A Expression. Mol Med. 2015 Apr 03; 21:323-36. Costantini TW, Dang X, Yurchyshyna MV, Coimbra R, Eliceiri BP, Baird A. PMID: 25860877.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    60. CHRFAM7A: a human-specific a7-nicotinic acetylcholine receptor gene shows differential responsiveness of human intestinal epithelial cells to LPS. FASEB J. 2015 Jun; 29(6):2292-302. Dang X, Eliceiri BP, Baird A, Costantini TW. PMID: 25681457.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    61. A pharmacologic approach to vagal nerve stimulation prevents mesenteric lymph toxicity after hemorrhagic shock. J Trauma Acute Care Surg. 2015 Jan; 78(1):52-8; discussion 58-9. Morishita K, Costantini TW, Ueno A, Bansal V, Eliceiri B, Coimbra R. PMID: 25539203.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    62. Esophageal cancer-related gene-4 (ECRG4) interactions with the innate immunity receptor complex. Inflamm Res. 2015 Feb; 64(2):107-18. Podvin S, Dang X, Meads M, Kurabi A, Costantini T, Eliceiri BP, Baird A, Coimbra R. PMID: 25511108.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    63. Pulmonary preconditioning, injury, and inflammation modulate expression of the candidate tumor suppressor gene ECRG4 in lung. Exp Lung Res. 2015 Apr; 41(3):162-72. Kao S, Shaterian A, Cauvi DM, Dang X, Chun HB, De Maio A, Costantini TW, Coimbra R, Eliceiri BP, Baird A. PMID: 25513848.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    64. CHRFAM7A, a human-specific and partially duplicated a7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury. J Leukoc Biol. 2015 Feb; 97(2):247-57. Costantini TW, Dang X, Coimbra R, Eliceiri BP, Baird A. PMID: 25473097.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    65. Altering leukocyte recruitment following traumatic brain injury with ghrelin therapy. J Trauma Acute Care Surg. 2014 Nov; 77(5):709-715. Lee J, Costantini TW, D'Mello R, Eliceiri BP, Coimbra R, Bansal V. PMID: 25494422.
      View in: PubMed   Mentions: 6     Fields:    
    66. The vagus nerve alters the pulmonary dendritic cell response to injury. J Surg Res. 2014 Nov; 192(1):12-8. Lowry DM, Morishita K, Eliceiri BP, Bansal V, Coimbra R, Costantini TW. PMID: 25005822.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    67. Cholinergic signaling in the gut: a novel mechanism of barrier protection through activation of enteric glia cells. Surg Infect (Larchmt). 2014 Aug; 15(4):387-93. Cheadle GA, Costantini TW, Bansal V, Eliceiri BP, Coimbra R. PMID: 24828283.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    68. Vagal nerve stimulation modulates the dendritic cell profile in posthemorrhagic shock mesenteric lymph. J Trauma Acute Care Surg. 2014 Mar; 76(3):610-7; discussion 617-8. Morishita K, Costantini TW, Eliceiri B, Bansal V, Coimbra R. PMID: 24553526.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    69. Esophageal cancer-related gene 4 at the interface of injury, inflammation, infection, and malignancy. Gastrointest Cancer. 2014; 2014(4):131-142. Baird A, Lee J, Podvin S, Kurabi A, Dang X, Coimbra R, Costantini T, Bansal V, Eliceiri BP. PMID: 25580077.
      View in: PubMed   Mentions:
    70. Abdominal damage control surgery and reconstruction: world society of emergency surgery position paper. World J Emerg Surg. 2013 Dec 17; 8(1):53. Godat L, Kobayashi L, Costantini T, Coimbra R. PMID: 24341602.
      View in: PubMed   Mentions: 22     Fields:    
    71. Enteric glia cells attenuate cytomix-induced intestinal epithelial barrier breakdown. PLoS One. 2013; 8(7):e69042. Cheadle GA, Costantini TW, Lopez N, Bansal V, Eliceiri BP, Coimbra R. PMID: 23840906.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    72. Vagal nerve stimulation protects cardiac injury by attenuating mitochondrial dysfunction in a murine burn injury model. J Cell Mol Med. 2013 May; 17(5):664-71. Lu X, Costantini T, Lopez NE, Wolf PL, Hageny AM, Putnam J, Eliceiri B, Coimbra R. PMID: 23577721.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    73. Limb salvage after complex repairs of extremity arterial injuries is independent of surgical specialty training. J Trauma Acute Care Surg. 2013 Mar; 74(3):716-23; discussion 723-4. Shackford SR, Kahl JE, Calvo RY, Shackford MC, Danos LA, Davis JW, Vercruysse GA, Feliciano DV, Moore EE, Moore HB, Knudson MM, Howard BM, Sise MJ, Coimbra RS, Costantini TW, Brakenridge SC, Tominaga GT, Schaffer KB, Steele JT, Kennedy FR, Cogbill TH. PMID: 23425727.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    74. Uncovering the neuroenteric-pulmonary axis: vagal nerve stimulation prevents acute lung injury following hemorrhagic shock. Life Sci. 2013 Apr 19; 92(13):783-92. Reys LG, Ortiz-Pomales YT, Lopez N, Cheadle G, de Oliveira PG, Eliceiri B, Bansal V, Costantini TW, Coimbra R. PMID: 23439327.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    75. Dose adjusting enoxaparin is necessary to achieve adequate venous thromboembolism prophylaxis in trauma patients. J Trauma Acute Care Surg. 2013 Jan; 74(1):128-33; discussion 134-5. Costantini TW, Min E, Box K, Tran V, Winfield RD, Fortlage D, Doucet J, Bansal V, Coimbra R. PMID: 23271087.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    76. Hypovolemic shock resuscitation. Surg Clin North Am. 2012 Dec; 92(6):1403-23. Kobayashi L, Costantini TW, Coimbra R. PMID: 23153876.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    77. Intravenous phage display identifies peptide sequences that target the burn-injured intestine. Peptides. 2012 Nov; 38(1):94-9. Costantini TW, Eliceiri BP, Putnam JG, Bansal V, Baird A, Coimbra R. PMID: 22960048.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    78. Vagal nerve stimulation blocks peritoneal macrophage inflammatory responsiveness after severe burn injury. Shock. 2012 Aug; 38(3):294-300. Lopez NE, Krzyzaniak M, Costantini TW, De Maio A, Baird A, Eliceiri BP, Coimbra R. PMID: 22683732.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    79. Syndecan 1 plays a novel role in enteral glutamine's gut-protective effects of the postischemic gut. Shock. 2012 Jul; 38(1):57-62. Peng Z, Ban K, Sen A, Grill R, Park P, Costantini TW, Kozar R. PMID: 22706022.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    80. Targeting a-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury. Am J Pathol. 2012 Aug; 181(2):478-86. Costantini TW, Krzyzaniak M, Cheadle GA, Putnam JG, Hageny AM, Lopez N, Eliceiri BP, Bansal V, Coimbra R. PMID: 22688057.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    81. Vagal nerve stimulation decreases blood-brain barrier disruption after traumatic brain injury. J Trauma Acute Care Surg. 2012 Jun; 72(6):1562-6. Lopez NE, Krzyzaniak MJ, Costantini TW, Putnam J, Hageny AM, Eliceiri B, Coimbra R, Bansal V. PMID: 22695423.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    82. Is contrast exposure safe among the highest risk trauma patients? J Trauma Acute Care Surg. 2012 Jan; 72(1):61-6; discussion 66-7. Kim DY, Kobayashi L, Costantini TW, Chang D, Fortlage D, Curry T, Wynn S, Doucet J, Bansal V, Coimbra R. PMID: 22310117.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    83. Arterial embolization for pelvic fractures after blunt trauma: are we all talk? Am J Surg. 2010 Dec; 200(6):752-7; discussion 757-8. Costantini TW, Bosarge PL, Fortlage D, Bansal V, Coimbra R. PMID: 21146016.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    84. The hormone ghrelin prevents traumatic brain injury induced intestinal dysfunction. J Neurotrauma. 2010 Dec; 27(12):2255-60. Bansal V, Ryu SY, Blow C, Costantini T, Loomis W, Eliceiri B, Baird A, Wolf P, Coimbra R. PMID: 20858122.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    85. Tumor necrosis factor expression is ameliorated after exposure to an acidic environment. J Surg Res. 2012 Mar; 173(1):127-34. Grabowski J, Vazquez DE, Costantini T, Cauvi DM, Charles W, Bickler S, Talamini MA, Vega VL, Coimbra R, De Maio A. PMID: 20888586.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    86. Vagal nerve stimulation protects against burn-induced intestinal injury through activation of enteric glia cells. Am J Physiol Gastrointest Liver Physiol. 2010 Dec; 299(6):G1308-18. Costantini TW, Bansal V, Krzyzaniak M, Putnam JG, Peterson CY, Loomis WH, Wolf P, Baird A, Eliceiri BP, Coimbra R. PMID: 20705905.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    87. Efferent vagal nerve stimulation attenuates gut barrier injury after burn: modulation of intestinal occludin expression. J Trauma. 2010 Jun; 68(6):1349-54; discussion 1354-6. Costantini TW, Bansal V, Peterson CY, Loomis WH, Putnam JG, Rankin F, Wolf P, Eliceiri BP, Baird A, Coimbra R. PMID: 20539179.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    88. A novel fluid resuscitation strategy modulates pulmonary transcription factor activation in a murine model of hemorrhagic shock. Clinics (Sao Paulo). 2010 Jun; 65(6):621-8. Costantini TW, Deree J, Martins JO, Putnam JG, Campos Td, Coimbra R. PMID: 20613939.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    89. Stimulating the central nervous system to prevent intestinal dysfunction after traumatic brain injury. J Trauma. 2010 May; 68(5):1059-64. Bansal V, Costantini T, Ryu SY, Peterson C, Loomis W, Putnam J, Elicieri B, Baird A, Coimbra R. PMID: 20453760.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    90. Concentration of arginine and optimal time of hypertonic saline in restoration of T-cell dysfunction. J Surg Res. 2010 Sep; 163(1):e17-22. Moon SW, Choi SH, Cho HJ, Yun YH, Kim JY, Hong YS, Costantini T, Bansal V. PMID: 20599217.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    91. Toll-like receptor-4 mediates intestinal barrier breakdown after thermal injury. Surg Infect (Larchmt). 2010 Apr; 11(2):137-44. Peterson CY, Costantini TW, Loomis WH, Putnam JG, Wolf P, Bansal V, Eliceiri BP, Baird A, Coimbra R. PMID: 20374005.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    92. Pentoxifylline modulates p47phox activation and downregulates neutrophil oxidative burst through PKA-dependent and -independent mechanisms. Immunopharmacol Immunotoxicol. 2010 Mar; 32(1):82-91. Costantini TW, Deree J, Peterson CY, Putnam JG, Woon T, Loomis WH, Bansal V, Coimbra R. PMID: 19839729.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    93. Children at danger: injury fatalities among children in San Diego County. Eur J Epidemiol. 2010 Mar; 25(3):211-7. Fraga AM, Fraga GP, Stanley C, Costantini TW, Coimbra R. PMID: 20084430.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    94. Pentoxifylline attenuates leukoreduced stored blood-induced neutrophil activation through inhibition of mitogen-activated protein kinases. Immunopharmacol Immunotoxicol. 2010 Mar; 32(1):74-81. Costantini TW, Deree J, Martins JO, Loomis WH, Bansal V, Coimbra R. PMID: 19697996.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    95. Quantitative assessment of intestinal injury using a novel in vivo, near-infrared imaging technique. Mol Imaging. 2010 Feb; 9(1):30-9. Costantini TW, Eliceiri BP, Peterson CY, Loomis WH, Putnam JG, Baird A, Wolf P, Bansal V, Coimbra R. PMID: 20128996.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    96. Burns, inflammation, and intestinal injury: protective effects of an anti-inflammatory resuscitation strategy. J Trauma. 2009 Dec; 67(6):1162-8. Costantini TW, Peterson CY, Kroll L, Loomis WH, Putnam JG, Wolf P, Eliceiri BP, Baird A, Bansal V, Coimbra R. PMID: 20009662.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    97. Redefining renal dysfunction in trauma: implementation of the Acute Kidney Injury Network staging system. J Trauma. 2009 Aug; 67(2):283-7; discussion 287-8. Costantini TW, Fraga G, Fortlage D, Wynn S, Fraga A, Lee J, Doucet J, Bansal V, Coimbra R. PMID: 19667880.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    98. Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis. J Neurotrauma. 2009 Aug; 26(8):1353-9. Bansal V, Costantini T, Kroll L, Peterson C, Loomis W, Eliceiri B, Baird A, Wolf P, Coimbra R. PMID: 19344293.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    99. Targeting the gut barrier: identification of a homing peptide sequence for delivery into the injured intestinal epithelial cell. Surgery. 2009 Aug; 146(2):206-12. Costantini TW, Putnam JG, Sawada R, Baird A, Loomis WH, Eliceiri BP, Bansal V, Coimbra R. PMID: 19628075.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    100. Real-time analysis of the kinetics of angiogenesis and vascular permeability in an animal model of wound healing. Burns. 2009 Sep; 35(6):811-7. Shaterian A, Borboa A, Sawada R, Costantini T, Potenza B, Coimbra R, Baird A, Eliceiri BP. PMID: 19423227.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    101. Role of p38 MAPK in burn-induced intestinal barrier breakdown. J Surg Res. 2009 Sep; 156(1):64-9. Costantini TW, Peterson CY, Kroll L, Loomis WH, Eliceiri BP, Baird A, Bansal V, Coimbra R. PMID: 19577248.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    102. Arginine is essential in reversing prostaglandin E(2) T-cell suppression by hypertonic saline. J Surg Res. 2009 Sep; 156(1):83-9. Choi SH, Bansal V, Costantini T, Putnam J, Loomis W, Coimbra R. PMID: 19577247.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    103. Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins. Shock. 2009 Apr; 31(4):416-22. Costantini TW, Loomis WH, Putnam JG, Drusinsky D, Deree J, Choi S, Wolf P, Baird A, Eliceiri B, Bansal V, Coimbra R. PMID: 18791495.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    104. Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase. J Trauma. 2009 Jan; 66(1):17-24; discussion 24-5. Costantini TW, Loomis WH, Putnam JG, Kroll L, Eliceiri BP, Baird A, Bansal V, Coimbra R. PMID: 19131801.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    105. Hemorrhage is More Prevalent than Brain Injury in Early Trauma Deaths: The Golden Six Hours. Eur J Trauma Emerg Surg. 2009 Feb; 35(1):26-30. Bansal V, Fortlage D, Lee JG, Costantini T, Potenza B, Coimbra R. PMID: 26814527.
      View in: PubMed   Mentions: 17     Fields:    
    106. Phosphodiesterase inhibition attenuates alterations to the tight junction proteins occludin and ZO-1 in immunostimulated Caco-2 intestinal monolayers. Life Sci. 2009 Jan 02; 84(1-2):18-22. Costantini TW, Deree J, Loomis W, Putnam JG, Choi S, Baird A, Eliceiri BP, Bansal V, Coimbra R. PMID: 18992758.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    107. Surgical resident and attending physician attitudes toward glucose control in the surgical patient. Am Surg. 2008 Oct; 74(10):993-6. Costantini TW, Acosta JA, Hoyt DB, Ramamoorthy S. PMID: 18942630.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    108. Abdominal complications of ventricular assist device placement. Surg Infect (Larchmt). 2005; 6(4):409-18. Costantini TW, Taylor JH, Beilman GJ. PMID: 16433605.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
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