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Todd Costantini

TitleAssociate Professor In Residence
InstitutionUniversity of California San Diego
DepartmentSurgery
Address200 W. Arbor Drive #8896
San Diego CA 92103
Phone619-543-7107
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    Collapse Overview
    Todd W. Costantini, MD is currently an Associate Professor of Surgery in the Division of Trauma, Surgical Critical Care, and Burns at the University of California, San Diego and the Trauma Medical Director at UC San Diego. Dr. Costantini is a graduate of the University of Minnesota Medical School. He completed his General Surgery residency at UC-San Diego and went on to complete a fellowship in Trauma and Surgical Critical Care at UC-San Diego under the direction of Dr. Raul Coimbra.
    Dr. Costantini is an investigator in the UC San Diego Laboratories of Trauma, Surgical Critical Care and Burn Research. Dr. Costantini’s basic science research focuses on the neural control of inflammation after severe injury. Dr. Costantini was previously awarded research fellowships by the American Association for the Surgery of Trauma (AAST), the American College of Surgeons, and the American Surgical Association. Dr. Costantini is the principal investigator on an NIH R01 research program focused on the ability of the uniquely human gene CHRFAM7A to contribute to human variability in the anti-inflammatory response to inflammation and injury. His clinical research interests include improving DVT prophylaxis in Trauma and Surgery patients and the study of complex pelvic fracture management. Dr. Costantini currently serves as the Chair of the Multi-institutional Trials Committee for the AAST. He also serves on the research council of the Coalition for National Trauma Research (CNTR) and the research committee of the American College of Surgeons Committee on Trauma.


    Collapse Research 
    Collapse Research Activities and Funding
    The Human-Specific Gene CHRFAM7A in Leukocytes
    NIH/NIGMS R01GM121530Apr 1, 2017 - Mar 31, 2022
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yuen L, Costantini TW, Coimbra R, Godat LN. Impact of the Affordable Care Act on elective general surgery clinical practice. Am J Surg. 2018 Nov 09. PMID: 30448210.
      View in: PubMed
    2. Chan T, Williams E, Cohen O, Eliceiri BP, Baird A, Costantini TW. CHRFAM7A alters Binding to the Neuronal alpha-7 Nicotinic Acetylcholine Receptor. Neurosci Lett. 2018 Oct 08. PMID: 30308236.
      View in: PubMed
    3. Bulger EM, Rasmussen TE, Jurkovich GJ, Fabian TC, Kozar RA, Coimbra R, Costantini TW, Ficke J, Malhotra AK, Price MA, Smith SL, Cioffi WG, Stewart RM. Implementation of a National Trauma Research Action Plan (NTRAP). J Trauma Acute Care Surg. 2018 Jun; 84(6):1012-1016. PMID: 29370052.
      View in: PubMed
    4. Nguyen V, Marmor RA, Ramamoorthy SL, Costantini TW, Baumgartner JM, Berumen J, Jacobsen GR, Sicklick JK. The Use of Solicited Publishing by Academic Surgeons. Surgery. 2018 Apr 30. PMID: 29724409.
      View in: PubMed
    5. Kojima M, Costantini TW, Eliceiri BP, Chan TW, Baird A, Coimbra R. Gut epithelial cell-derived exosomes trigger posttrauma immune dysfunction. J Trauma Acute Care Surg. 2018 Feb; 84(2):257-264. PMID: 29194317.
      View in: PubMed
    6. Baumgartner JM, McKenzie S, Block S, Costantini TW, Lowy AM. Prophylactic enoxaparin doses may be inadequate in patients undergoing abdominal cancer surgery. J Surg Res. 2018 Jan; 221:183-189. PMID: 29229126.
      View in: PubMed
    7. Kojima M, Gimenes-Junior JA, Chan TW, Eliceiri BP, Baird A, Costantini TW, Coimbra R. Exosomes in postshock mesenteric lymph are key mediators of acute lung injury triggering the macrophage activation via Toll-like receptor 4. FASEB J. 2018 Jan; 32(1):97-110. PMID: 28855278.
      View in: PubMed
    8. Costantini TW, Coimbra R, Holcomb JB, Podbielski JM, Catalano RD, Blackburn A, Scalea TM, Stein DM, Williams L, Conflitti J, Keeney S, Hoey C, Zhou T, Sperry J, Skiada D, Inaba K, Williams BH, Minei JP, Privette A, Mackersie RC, Robinson BR, Moore FO. Pelvic fracture pattern predicts the need for hemorrhage control intervention-Results of an AAST multi-institutional study. J Trauma Acute Care Surg. 2017 06; 82(6):1030-1038. PMID: 28520685.
      View in: PubMed
    9. Jubbal KT, Chen C, Costantini T, Herrera F, Dobke M, Suliman A. Analysis of Surfing Injuries Presenting in the Acute Trauma Setting. Ann Plast Surg. 2017 May; 78(5 Suppl 4):S233-S237. PMID: 28301362.
      View in: PubMed
    10. Langness S, Kojima M, Coimbra R, Eliceiri BP, Costantini TW. Enteric glia cells are critical to limiting the intestinal inflammatory response after injury. Am J Physiol Gastrointest Liver Physiol. 2017 Mar 01; 312(3):G274-G282. PMID: 28082286.
      View in: PubMed
    11. Kojima M, Gimenes-Junior JA, Langness S, Morishita K, Lavoie-Gagne O, Eliceiri B, Costantini TW, Coimbra R. Exosomes, not protein or lipids, in mesenteric lymph activate inflammation: Unlocking the mystery of post-shock multiple organ failure. J Trauma Acute Care Surg. 2017 Jan; 82(1):42-50. PMID: 27779585.
      View in: PubMed
    12. Langness S, Costantini TW, Morishita K, Eliceiri BP, Coimbra R. Modulating the Biologic Activity of Mesenteric Lymph after Traumatic Shock Decreases Systemic Inflammation and End Organ Injury. PLoS One. 2016; 11(12):e0168322. PMID: 27977787.
      View in: PubMed
    13. Berndtson AE, Costantini TW, Lane J, Box K, Coimbra R. If some is good, more is better: An enoxaparin dosing strategy to improve pharmacologic venous thromboembolism prophylaxis. J Trauma Acute Care Surg. 2016 12; 81(6):1095-1100. PMID: 27244575.
      View in: PubMed
    14. Baird A, Deng C, Eliceiri MH, Haghi F, Dang X, Coimbra R, Costantini TW, Torbett BE, Eliceiri BP. Mice engrafted with human hematopoietic stem cells support a human myeloid cell inflammatory response in vivo. Wound Repair Regen. 2016 11; 24(6):1004-1014. PMID: 27663454.
      View in: PubMed
    15. Berndtson AE, Costantini TW, Smith AM, Kobayashi L, Coimbra R. Does sex matter? Effects on venous thromboembolism risk in screened trauma patients. J Trauma Acute Care Surg. 2016 09; 81(3):493-9. PMID: 27280942.
      View in: PubMed
    16. Costantini TW, Baird A. Lost your nerve? Modulating the parasympathetic nervous system to treat inflammatory bowel disease. J Physiol. 2016 08 01; 594(15):4097-8. PMID: 27477606; PMCID: PMC4967743 [Available on 08/01/17].
    17. Kobayashi LM, Costantini TW, Hamel MG, Dierksheide JE, Coimbra R. Abdominal vascular trauma. Trauma Surg Acute Care Open. 2016; 1(1):e000015. PMID: 29766059.
      View in: PubMed
    18. Langness S, Costantini TW, Smith A, Bansal V, Coimbra R. Isolated traumatic brain injury in patients with cirrhosis: do different treatment paradigms result in increased mortality? Am J Surg. 2017 Jan; 213(1):80-86. PMID: 27421188.
      View in: PubMed
    19. Costantini TW, Coimbra R, Holcomb JB, Podbielski JM, Catalano R, Blackburn A, Scalea TM, Stein DM, Williams L, Conflitti J, Keeney S, Suleiman G, Zhou T, Sperry J, Skiada D, Inaba K, Williams BH, Minei JP, Privette A, Mackersie RC, Robinson BR, Moore FO. Current management of hemorrhage from severe pelvic fractures: Results of an American Association for the Surgery of Trauma multi-institutional trial. J Trauma Acute Care Surg. 2016 May; 80(5):717-23; discussion 723-5. PMID: 26958799.
      View in: PubMed
    20. Baird A, Costantini T, Coimbra R, Eliceiri BP. Injury, inflammation and the emergence of human-specific genes. Wound Repair Regen. 2016 05; 24(3):602-6. PMID: 26874655.
      View in: PubMed
    21. Baird A, Coimbra R, Dang X, Eliceiri BP, Costantini TW. Up-regulation of the human-specific CHRFAM7A gene in inflammatory bowel disease. BBA Clin. 2016 Jun; 5:66-71. PMID: 27051591; PMCID: PMC4802402.
    22. Costantini TW, Meads M, Dang X, Coimbra R, Torbett BE, Baird A, Eliceiri BP. The Response to Burn Injury in Mice With Human Hematolymphoid Systems. Ann Surg. 2016 Jan; 263(1):199-204. PMID: 25575256.
      View in: PubMed
    23. Langness S, Coimbra R, Costantini T. Complexities of the Enteric Nervous System: In Reply to Fujita. J Am Coll Surg. 2016 Jan; 222(1):105-6. PMID: 26721758.
      View in: PubMed
    24. Costantini TW, Coimbra R, Lopez NE, Lee JG, Potenza B, Smith A, Baird A, Eliceiri BP. Monitoring Neutrophil-Expressed Cell Surface Esophageal Cancer Related Gene-4 after Severe Burn Injury. Surg Infect (Larchmt). 2015 Dec; 16(6):669-74. PMID: 26460850; PMCID: PMC4663648 [Available on 12/01/16].
    25. Langness S, Coimbra R, Eliceiri BP, Costantini TW. Vagus Nerve Mediates the Neural Stem Cell Response to Intestinal Injury. J Am Coll Surg. 2015 Oct; 221(4):871-9. PMID: 26209457.
      View in: PubMed
    26. Morishita K, Coimbra R, Langness S, Eliceiri BP, Costantini TW. Neuroenteric axis modulates the balance of regulatory T cells and T-helper 17 cells in the mesenteric lymph node following trauma/hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 01; 309(3):G202-8. PMID: 26045612.
      View in: PubMed
    27. Costantini TW, Dang X, Yurchyshyna MV, Coimbra R, Eliceiri BP, Baird A. A Human-Specific a7-Nicotinic Acetylcholine Receptor Gene in Human Leukocytes: Identification, Regulation and the Consequences of CHRFAM7A Expression. Mol Med. 2015 Apr 03; 21:323-36. PMID: 25860877; PMCID: PMC4534468.
    28. Dang X, Eliceiri BP, Baird A, Costantini TW. CHRFAM7A: a human-specific a7-nicotinic acetylcholine receptor gene shows differential responsiveness of human intestinal epithelial cells to LPS. FASEB J. 2015 Jun; 29(6):2292-302. PMID: 25681457; PMCID: PMC4763870.
    29. Morishita K, Costantini TW, Ueno A, Bansal V, Eliceiri B, Coimbra R. A pharmacologic approach to vagal nerve stimulation prevents mesenteric lymph toxicity after hemorrhagic shock. J Trauma Acute Care Surg. 2015 Jan; 78(1):52-8; discussion 58-9. PMID: 25539203.
      View in: PubMed
    30. Kao S, Shaterian A, Cauvi DM, Dang X, Chun HB, De Maio A, Costantini TW, Coimbra R, Eliceiri BP, Baird A. Pulmonary preconditioning, injury, and inflammation modulate expression of the candidate tumor suppressor gene ECRG4 in lung. Exp Lung Res. 2015 Apr; 41(3):162-72. PMID: 25513848; PMCID: PMC4524537.
    31. Podvin S, Dang X, Meads M, Kurabi A, Costantini T, Eliceiri BP, Baird A, Coimbra R. Esophageal cancer-related gene-4 (ECRG4) interactions with the innate immunity receptor complex. Inflamm Res. 2015 Feb; 64(2):107-18. PMID: 25511108; PMCID: PMC4301958.
    32. Costantini TW, Dang X, Coimbra R, Eliceiri BP, Baird A. CHRFAM7A, a human-specific and partially duplicated a7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury. J Leukoc Biol. 2015 Feb; 97(2):247-57. PMID: 25473097; PMCID: PMC4304420.
    33. Lee J, Costantini TW, D'Mello R, Eliceiri BP, Coimbra R, Bansal V. Altering leukocyte recruitment following traumatic brain injury with ghrelin therapy. J Trauma Acute Care Surg. 2014 Nov; 77(5):709-715. PMID: 25494422.
      View in: PubMed
    34. Lowry DM, Morishita K, Eliceiri BP, Bansal V, Coimbra R, Costantini TW. The vagus nerve alters the pulmonary dendritic cell response to injury. J Surg Res. 2014 Nov; 192(1):12-8. PMID: 25005822.
      View in: PubMed
    35. Cheadle GA, Costantini TW, Bansal V, Eliceiri BP, Coimbra R. Cholinergic signaling in the gut: a novel mechanism of barrier protection through activation of enteric glia cells. Surg Infect (Larchmt). 2014 Aug; 15(4):387-93. PMID: 24828283.
      View in: PubMed
    36. Morishita K, Costantini TW, Eliceiri B, Bansal V, Coimbra R. Vagal nerve stimulation modulates the dendritic cell profile in posthemorrhagic shock mesenteric lymph. J Trauma Acute Care Surg. 2014 Mar; 76(3):610-7; discussion 617-8. PMID: 24553526.
      View in: PubMed
    37. Baird A, Lee J, Podvin S, Kurabi A, Dang X, Coimbra R, Costantini T, Bansal V, Eliceiri BP. Esophageal cancer-related gene 4 at the interface of injury, inflammation, infection, and malignancy. Gastrointest Cancer. 2014; 2014(4):131-142. PMID: 25580077.
      View in: PubMed
    38. Godat L, Kobayashi L, Costantini T, Coimbra R. Abdominal damage control surgery and reconstruction: world society of emergency surgery position paper. World J Emerg Surg. 2013 Dec 17; 8(1):53. PMID: 24341602; PMCID: PMC3878509.
    39. Cheadle GA, Costantini TW, Lopez N, Bansal V, Eliceiri BP, Coimbra R. Enteric glia cells attenuate cytomix-induced intestinal epithelial barrier breakdown. PLoS One. 2013; 8(7):e69042. PMID: 23840906; PMCID: PMC3698076.
    40. Lu X, Costantini T, Lopez NE, Wolf PL, Hageny AM, Putnam J, Eliceiri B, Coimbra R. Vagal nerve stimulation protects cardiac injury by attenuating mitochondrial dysfunction in a murine burn injury model. J Cell Mol Med. 2013 May; 17(5):664-71. PMID: 23577721; PMCID: PMC3822819.
    41. Shackford SR, Kahl JE, Calvo RY, Shackford MC, Danos LA, Davis JW, Vercruysse GA, Feliciano DV, Moore EE, Moore HB, Knudson MM, Howard BM, Sise MJ, Coimbra RS, Costantini TW, Brakenridge SC, Tominaga GT, Schaffer KB, Steele JT, Kennedy FR, Cogbill TH. Limb salvage after complex repairs of extremity arterial injuries is independent of surgical specialty training. J Trauma Acute Care Surg. 2013 Mar; 74(3):716-23; discussion 723-4. PMID: 23425727.
      View in: PubMed
    42. Reys LG, Ortiz-Pomales YT, Lopez N, Cheadle G, de Oliveira PG, Eliceiri B, Bansal V, Costantini TW, Coimbra R. Uncovering the neuroenteric-pulmonary axis: vagal nerve stimulation prevents acute lung injury following hemorrhagic shock. Life Sci. 2013 Apr 19; 92(13):783-92. PMID: 23439327.
      View in: PubMed
    43. Costantini TW, Min E, Box K, Tran V, Winfield RD, Fortlage D, Doucet J, Bansal V, Coimbra R. Dose adjusting enoxaparin is necessary to achieve adequate venous thromboembolism prophylaxis in trauma patients. J Trauma Acute Care Surg. 2013 Jan; 74(1):128-33; discussion 134-5. PMID: 23271087; PMCID: PMC4010946.
    44. Kobayashi L, Costantini TW, Coimbra R. Hypovolemic shock resuscitation. Surg Clin North Am. 2012 Dec; 92(6):1403-23. PMID: 23153876.
      View in: PubMed
    45. Costantini TW, Eliceiri BP, Putnam JG, Bansal V, Baird A, Coimbra R. Intravenous phage display identifies peptide sequences that target the burn-injured intestine. Peptides. 2012 Nov; 38(1):94-9. PMID: 22960048; PMCID: PMC4524536.
    46. Lopez NE, Krzyzaniak M, Costantini TW, De Maio A, Baird A, Eliceiri BP, Coimbra R. Vagal nerve stimulation blocks peritoneal macrophage inflammatory responsiveness after severe burn injury. Shock. 2012 Aug; 38(3):294-300. PMID: 22683732; PMCID: PMC3422402.
    47. Peng Z, Ban K, Sen A, Grill R, Park P, Costantini TW, Kozar R. Syndecan 1 plays a novel role in enteral glutamine's gut-protective effects of the postischemic gut. Shock. 2012 Jul; 38(1):57-62. PMID: 22706022; PMCID: PMC3391586.
    48. Costantini TW, Krzyzaniak M, Cheadle GA, Putnam JG, Hageny AM, Lopez N, Eliceiri BP, Bansal V, Coimbra R. Targeting a-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury. Am J Pathol. 2012 Aug; 181(2):478-86. PMID: 22688057.
      View in: PubMed
    49. Lopez NE, Krzyzaniak MJ, Costantini TW, Putnam J, Hageny AM, Eliceiri B, Coimbra R, Bansal V. Vagal nerve stimulation decreases blood-brain barrier disruption after traumatic brain injury. J Trauma Acute Care Surg. 2012 Jun; 72(6):1562-6. PMID: 22695423.
      View in: PubMed
    50. Kim DY, Kobayashi L, Costantini TW, Chang D, Fortlage D, Curry T, Wynn S, Doucet J, Bansal V, Coimbra R. Is contrast exposure safe among the highest risk trauma patients? J Trauma Acute Care Surg. 2012 Jan; 72(1):61-6; discussion 66-7. PMID: 22310117.
      View in: PubMed
    51. Costantini TW, Bosarge PL, Fortlage D, Bansal V, Coimbra R. Arterial embolization for pelvic fractures after blunt trauma: are we all talk? Am J Surg. 2010 Dec; 200(6):752-7; discussion 757-8. PMID: 21146016.
      View in: PubMed
    52. Bansal V, Ryu SY, Blow C, Costantini T, Loomis W, Eliceiri B, Baird A, Wolf P, Coimbra R. The hormone ghrelin prevents traumatic brain injury induced intestinal dysfunction. J Neurotrauma. 2010 Dec; 27(12):2255-60. PMID: 20858122; PMCID: PMC3304249.
    53. Grabowski J, Vazquez DE, Costantini T, Cauvi DM, Charles W, Bickler S, Talamini MA, Vega VL, Coimbra R, De Maio A. Tumor necrosis factor expression is ameliorated after exposure to an acidic environment. J Surg Res. 2012 Mar; 173(1):127-34. PMID: 20888586; PMCID: PMC3017641.
    54. Costantini TW, Bansal V, Krzyzaniak M, Putnam JG, Peterson CY, Loomis WH, Wolf P, Baird A, Eliceiri BP, Coimbra R. Vagal nerve stimulation protects against burn-induced intestinal injury through activation of enteric glia cells. Am J Physiol Gastrointest Liver Physiol. 2010 Dec; 299(6):G1308-18. PMID: 20705905; PMCID: PMC3774266.
    55. Costantini TW, Bansal V, Peterson CY, Loomis WH, Putnam JG, Rankin F, Wolf P, Eliceiri BP, Baird A, Coimbra R. Efferent vagal nerve stimulation attenuates gut barrier injury after burn: modulation of intestinal occludin expression. J Trauma. 2010 Jun; 68(6):1349-54; discussion 1354-6. PMID: 20539179; PMCID: PMC4251593.
    56. Costantini TW, Deree J, Martins JO, Putnam JG, Campos Td, Coimbra R. A novel fluid resuscitation strategy modulates pulmonary transcription factor activation in a murine model of hemorrhagic shock. Clinics (Sao Paulo). 2010 Jun; 65(6):621-8. PMID: 20613939; PMCID: PMC2898548.
    57. Bansal V, Costantini T, Ryu SY, Peterson C, Loomis W, Putnam J, Elicieri B, Baird A, Coimbra R. Stimulating the central nervous system to prevent intestinal dysfunction after traumatic brain injury. J Trauma. 2010 May; 68(5):1059-64. PMID: 20453760; PMCID: PMC4251579.
    58. Moon SW, Choi SH, Cho HJ, Yun YH, Kim JY, Hong YS, Costantini T, Bansal V. Concentration of arginine and optimal time of hypertonic saline in restoration of T-cell dysfunction. J Surg Res. 2010 Sep; 163(1):e17-22. PMID: 20599217.
      View in: PubMed
    59. Peterson CY, Costantini TW, Loomis WH, Putnam JG, Wolf P, Bansal V, Eliceiri BP, Baird A, Coimbra R. Toll-like receptor-4 mediates intestinal barrier breakdown after thermal injury. Surg Infect (Larchmt). 2010 Apr; 11(2):137-44. PMID: 20374005; PMCID: PMC3304242.
    60. Costantini TW, Deree J, Peterson CY, Putnam JG, Woon T, Loomis WH, Bansal V, Coimbra R. Pentoxifylline modulates p47phox activation and downregulates neutrophil oxidative burst through PKA-dependent and -independent mechanisms. Immunopharmacol Immunotoxicol. 2010 Mar; 32(1):82-91. PMID: 19839729.
      View in: PubMed
    61. Fraga AM, Fraga GP, Stanley C, Costantini TW, Coimbra R. Children at danger: injury fatalities among children in San Diego County. Eur J Epidemiol. 2010 Mar; 25(3):211-7. PMID: 20084430; PMCID: PMC2836467.
    62. Costantini TW, Deree J, Martins JO, Loomis WH, Bansal V, Coimbra R. Pentoxifylline attenuates leukoreduced stored blood-induced neutrophil activation through inhibition of mitogen-activated protein kinases. Immunopharmacol Immunotoxicol. 2010 Mar; 32(1):74-81. PMID: 19697996.
      View in: PubMed
    63. Costantini TW, Eliceiri BP, Peterson CY, Loomis WH, Putnam JG, Baird A, Wolf P, Bansal V, Coimbra R. Quantitative assessment of intestinal injury using a novel in vivo, near-infrared imaging technique. Mol Imaging. 2010 Feb; 9(1):30-9. PMID: 20128996; PMCID: PMC4241240.
    64. Costantini TW, Peterson CY, Kroll L, Loomis WH, Putnam JG, Wolf P, Eliceiri BP, Baird A, Bansal V, Coimbra R. Burns, inflammation, and intestinal injury: protective effects of an anti-inflammatory resuscitation strategy. J Trauma. 2009 Dec; 67(6):1162-8. PMID: 20009662; PMCID: PMC4251580.
    65. Bansal V, Costantini T, Kroll L, Peterson C, Loomis W, Eliceiri B, Baird A, Wolf P, Coimbra R. Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis. J Neurotrauma. 2009 Aug; 26(8):1353-9. PMID: 19344293; PMCID: PMC2989839.
    66. Costantini TW, Putnam JG, Sawada R, Baird A, Loomis WH, Eliceiri BP, Bansal V, Coimbra R. Targeting the gut barrier: identification of a homing peptide sequence for delivery into the injured intestinal epithelial cell. Surgery. 2009 Aug; 146(2):206-12. PMID: 19628075; PMCID: PMC4251594.
    67. Costantini TW, Fraga G, Fortlage D, Wynn S, Fraga A, Lee J, Doucet J, Bansal V, Coimbra R. Redefining renal dysfunction in trauma: implementation of the Acute Kidney Injury Network staging system. J Trauma. 2009 Aug; 67(2):283-7; discussion 287-8. PMID: 19667880.
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    68. Shaterian A, Borboa A, Sawada R, Costantini T, Potenza B, Coimbra R, Baird A, Eliceiri BP. Real-time analysis of the kinetics of angiogenesis and vascular permeability in an animal model of wound healing. Burns. 2009 Sep; 35(6):811-7. PMID: 19423227; PMCID: PMC2739287.
    69. Costantini TW, Peterson CY, Kroll L, Loomis WH, Eliceiri BP, Baird A, Bansal V, Coimbra R. Role of p38 MAPK in burn-induced intestinal barrier breakdown. J Surg Res. 2009 Sep; 156(1):64-9. PMID: 19577248; PMCID: PMC4251589.
    70. Choi SH, Bansal V, Costantini T, Putnam J, Loomis W, Coimbra R. Arginine is essential in reversing prostaglandin E(2) T-cell suppression by hypertonic saline. J Surg Res. 2009 Sep; 156(1):83-9. PMID: 19577247.
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    71. Costantini TW, Loomis WH, Putnam JG, Drusinsky D, Deree J, Choi S, Wolf P, Baird A, Eliceiri B, Bansal V, Coimbra R. Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins. Shock. 2009 Apr; 31(4):416-22. PMID: 18791495; PMCID: PMC3445035.
    72. Costantini TW, Loomis WH, Putnam JG, Kroll L, Eliceiri BP, Baird A, Bansal V, Coimbra R. Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase. J Trauma. 2009 Jan; 66(1):17-24; discussion 24-5. PMID: 19131801; PMCID: PMC4251583.
    73. Lee J, Costantini TW, Coimbra R. Acute lower GI bleeding for the acute care surgeon: current diagnosis and management. Scand J Surg. 2009; 98(3):135-42. PMID: 19919917.
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    74. Bansal V, Fortlage D, Lee JG, Costantini T, Potenza B, Coimbra R. Hemorrhage is More Prevalent than Brain Injury in Early Trauma Deaths: The Golden Six Hours. Eur J Trauma Emerg Surg. 2009 Feb; 35(1):26-30. PMID: 26814527.
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    75. Costantini TW, Deree J, Loomis W, Putnam JG, Choi S, Baird A, Eliceiri BP, Bansal V, Coimbra R. Phosphodiesterase inhibition attenuates alterations to the tight junction proteins occludin and ZO-1 in immunostimulated Caco-2 intestinal monolayers. Life Sci. 2009 Jan 02; 84(1-2):18-22. PMID: 18992758.
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    76. Costantini TW, Acosta JA, Hoyt DB, Ramamoorthy S. Surgical resident and attending physician attitudes toward glucose control in the surgical patient. Am Surg. 2008 Oct; 74(10):993-6. PMID: 18942630.
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    77. Costantini TW, Taylor JH, Beilman GJ. Abdominal complications of ventricular assist device placement. Surg Infect (Larchmt). 2005; 6(4):409-18. PMID: 16433605.
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