Todd Costantini

Title(s)Professor, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Todd W. Costantini, MD is currently an Associate Professor of Surgery in the Division of Trauma, Surgical Critical Care, and Burns at the University of California, San Diego and the Trauma Medical Director at UC San Diego. Dr. Costantini is a graduate of the University of Minnesota Medical School. He completed his General Surgery residency at UC-San Diego and went on to complete a fellowship in Trauma and Surgical Critical Care at UC-San Diego under the direction of Dr. Raul Coimbra.
    Dr. Costantini is an investigator in the UC San Diego Laboratories of Trauma, Surgical Critical Care and Burn Research. Dr. Costantini’s basic science research focuses on the neural control of inflammation after severe injury. Dr. Costantini was previously awarded research fellowships by the American Association for the Surgery of Trauma (AAST), the American College of Surgeons, and the American Surgical Association. Dr. Costantini is the principal investigator on an NIH R01 research program focused on the ability of the uniquely human gene CHRFAM7A to contribute to human variability in the anti-inflammatory response to inflammation and injury. His clinical research interests include improving DVT prophylaxis in Trauma and Surgery patients and the study of complex pelvic fracture management. Dr. Costantini currently serves as the Chair of the Multi-institutional Trials Committee for the AAST. He also serves on the research council of the Coalition for National Trauma Research (CNTR) and the research committee of the American College of Surgeons Committee on Trauma.

    Collapse Research 
    Collapse Research Activities and Funding
    2021 Consensus Conference to Implement Optimal VTE Prophylaxis in Trauma
    NIH R13HL158206Jun 22, 2021 - May 31, 2022
    Role: Principal Investigator
    The Human-Specific Gene CHRFAM7A in Leukocytes
    NIH R01GM121530Apr 1, 2017 - Mar 31, 2022
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Excluding Hollow Viscus Injury for Abdominal Seat Belt Sign Using Computed Tomography. JAMA Surg. 2022 09 01; 157(9):771-778. Delaplain PT, Tay-Lasso E, Biffl WL, Schaffer KB, Sundel M, Behdin S, Ghneim M, Costantini TW, Santorelli JE, Switzer E, Schellenberg M, Keeley JA, Kim DY, Wang A, Dhillon NK, Patel D, Campion EM, Robinson CK, Kartiko S, Quintana MT, Estroff JM, Kirby KA, Nahmias J. PMID: 35830194; PMCID: PMC9280606.
      View in: PubMed   Mentions:    Fields:    
    2. One Size Does Not Fit All - Sex Bias in Pharmacologic Venous Thromboembolism Prophylaxis. J Trauma Acute Care Surg. 2022 Jul 05. Modi RN, Borst JM, Kirchberg TN, Box K, Smith AM, Godat LN, Doucet JJ, Costantini TW, Berndtson AE. PMID: 35787601.
      View in: PubMed   Mentions:    Fields:    
    3. Association of 30-ft US-Mexico Border Wall in San Diego With Increased Migrant Deaths, Trauma Center Admissions, and Injury Severity. JAMA Surg. 2022 07 01; 157(7):633-635. Liepert AE, Berndtson AE, Hill LL, Weaver JL, Godat LN, Costantini TW, Doucet JJ. PMID: 35486395; PMCID: PMC9055512.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Adolescent Trauma During the COVID Pandemic: Just Like Adults, Children, or Someone Else? Am Surg. 2022 May 18; 31348221101475. Ruhi-Williams P, Yeates EO, Grigorian A, Schellenberg M, Owattanapanich N, Barmparas G, Margulies D, Juillard C, Garber K, Cryer H, Tillou A, Burruss S, Penaloza-Villalobos L, Lin A, Figueras RA, Coimbra R, Brenner M, Costantini T, Santorelli J, Curry T, Wintz D, Biffl WL, Schaffer KB, Duncan TK, Barbaro C, Diaz G, Johnson A, Chinn J, Naaseh A, Leung A, Grabar C, Nahmias J. PMID: 35583103; PMCID: PMC9127450.
      View in: PubMed   Mentions: 1     Fields:    
    5. Predictors of Readmission Following Treatment for Traumatic Hemothorax. J Surg Res. 2022 09; 277:365-371. Kirchberg TN, Costantini TW, Santorelli J, Doucet JJ, Godat LN. PMID: 35569214.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Developing a National Trauma Research Action Plan: Results from the acute resuscitation, initial patient evaluation, imaging, and management research gap Delphi survey. J Trauma Acute Care Surg. 2022 08 01; 93(2):200-208. Costantini TW, Galante JM, Braverman MA, Phuong J, Price MA, Cuschieri J, Godat LN, Holcomb JB, Coimbra R, Bulger EM, NTRAP Acute Resuscitation Panel. PMID: 35444148.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Fluoxetine reduces organ injury and improves motor function after traumatic brain injury in mice. J Trauma Acute Care Surg. 2022 07 01; 93(1):38-42. Weaver JL, Eliceiri B, Costantini TW. PMID: 35727591.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    8. Author reply: Not so FAST-chest ultrasound underdiagnoses traumatic pneumothorax. J Trauma Acute Care Surg. 2022 07 01; 93(1):e43. Santorelli JE, Chau H, Godat L, Casola G, Doucet JJ, Costantini TW. PMID: 35358105.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Response to Letter to the Editor: Not so FAST-chest ultrasound underdiagnoses traumatic pneumothorax. J Trauma Acute Care Surg. 2022 07 01; 93(1):e41. Santorelli JE, Chau H, Godat L, Casola G, Doucet JJ, Costantini TW. PMID: 35358155.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Youth violence prevention can be enhanced by geospatial analysis of trauma registry data. J Trauma Acute Care Surg. 2022 Oct 01; 93(4):482-487. Doucet JJ, Godat LN, Berndtson AE, Liepert AE, Weaver JL, Smith AM, Kobayashi LM, Biffl WL, Costantini TW. PMID: 35343924.
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    11. Validating the Brain Injury Guidelines: Results of an American Association for the Surgery of Trauma prospective multi-institutional trial. J Trauma Acute Care Surg. 2022 08 01; 93(2):157-165. Joseph B, Obaid O, Dultz L, Black G, Campbell M, Berndtson AE, Costantini T, Kerwin A, Skarupa D, Burruss S, Delgado L, Gomez M, Mederos DR, Winfield R, Cullinane D, AAST BIG Multi-institutional Study Group. PMID: 35343931.
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    12. Response to letter to the editor. J Trauma Acute Care Surg. 2022 07 01; 93(1):e44-e45. Santorelli JE, Chau H, Godat L, Casola G, Doucet JJ, Costantini TW. PMID: 35293372.
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    13. American Association for the Surgery of Trauma/American College of Surgeons-Committee on Trauma Clinical Protocol for inpatient venous thromboembolism prophylaxis after trauma. J Trauma Acute Care Surg. 2022 03 01; 92(3):597-604. Yorkgitis BK, Berndtson AE, Cross A, Kennedy R, Kochuba MP, Tignanelli C, Tominaga GT, Jacobs DG, Marx WH, Ashley DW, Ley EJ, Napolitano L, Costantini TW. PMID: 34797813.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Decreased hospital length of stay and intensive care unit admissions for non-COVID blunt trauma patients during the COVID-19 pandemic. Am J Surg. 2022 07; 224(1 Pt A):90-95. Yeates EO, Grigorian A, Schellenberg M, Owattanapanich N, Barmparas G, Margulies D, Juillard C, Garber K, Cryer H, Tillou A, Burruss S, Penaloza-Villalobos L, Lin A, Figueras RA, Coimbra R, Brenner M, Costantini T, Santorelli J, Curry T, Wintz D, Biffl WL, Schaffer KB, Duncan TK, Barbaro C, Diaz G, Johnson A, Chinn J, Naaseh A, Leung A, Grabar C, Nahmias J. PMID: 35219493; PMCID: PMC8863305.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    15. Challenging Traditional Paradigms in Posttraumatic Pulmonary Thromboembolism. JAMA Surg. 2022 02 01; 157(2):e216356. Knudson MM, Moore EE, Kornblith LZ, Shui AM, Brakenridge S, Bruns BR, Cipolle MD, Costantini TW, Crookes BA, Haut ER, Kerwin AJ, Kiraly LN, Knowlton LM, Martin MJ, McNutt MK, Milia DJ, Mohr A, Nirula R, Rogers FB, Scalea TM, Sixta SL, Spain DA, Wade CE, Velmahos GC. PMID: 34910098; PMCID: PMC8674801.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Precision targeting of the vagal anti-inflammatory pathway attenuates the systemic inflammatory response to burn injury. J Trauma Acute Care Surg. 2022 02 01; 92(2):323-329. Costantini TW, Coimbra R, Weaver JL, Eliceiri BP. PMID: 34789702; PMCID: PMC8792272.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. Impact of time to surgery on mortality in hypotensive patients with noncompressible torso hemorrhage: An AAST multicenter, prospective study. J Trauma Acute Care Surg. 2022 05 01; 92(5):801-811. Duchesne J, Slaughter K, Puente I, Berne JD, Yorkgitis B, Mull J, Sperry J, Tessmer M, Costantini T, Berndtson AE, Kai T, Rokvic G, Norwood S, Meadows K, Chang G, Lemon BM, Jacome T, Van Sant L, Paul J, Maher Z, Goldberg AJ, Madayag RM, Pinson G, Lieser MJ, Haan J, Marshall G, Carrick M, Tatum D. PMID: 35468112.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. AAST multicenter prospective analysis of prehospital tourniquet use for extremity trauma. J Trauma Acute Care Surg. 2022 06 01; 92(6):997-1004. Schroll R, Smith A, Alabaster K, Schroeppel TJ, Stillman ZE, Teicher EJ, Lita E, Ferrada P, Han J, Fullerton RD, McNickle AG, Fraser DR, Truitt MS, Grossman Verner HM, Todd SR, Turay D, Pop A, Godat LN, Costantini TW, Khor D, Inaba K, Bardes J, Wilson A, Myers JG, Haan JM, Lightwine KL, Berdel HO, Bottiggi AJ, Dorlac W, Zier L, Chang G, Lindner M, Martinez B, Tatum D, Fischer PE, Lieser M, Mabe RC, Lottenberg L, Velopoulos CG, Urban S, Duke M, Brown A, Peckham M, Gongola A, Enniss TM, Teixeira P, Kim DY, Singer G, Ekeh P, Hardman C, Askari R, Okafor B, Duchesne J. PMID: 35609289.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Not so FAST-Chest ultrasound underdiagnoses traumatic pneumothorax. J Trauma Acute Care Surg. 2022 01 01; 92(1):44-48. Santorelli JE, Chau H, Godat L, Casola G, Doucet JJ, Costantini TW. PMID: 34932040.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    20. Electronic health record machine learning model predicts trauma inpatient mortality in real time: A validation study. J Trauma Acute Care Surg. 2022 01 01; 92(1):74-80. Mou Z, Godat LN, El-Kareh R, Berndtson AE, Doucet JJ, Costantini TW. PMID: 34932043; PMCID: PMC9032917.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Effects of the COVID-19 pandemic on pediatric trauma in Southern California. Pediatr Surg Int. 2022 Feb; 38(2):307-315. Yeates EO, Grigorian A, Schellenberg M, Owattanapanich N, Barmparas G, Margulies D, Juillard C, Garber K, Cryer H, Tillou A, Burruss S, Penaloza-Villalobos L, Lin A, Figueras RA, Coimbra R, Brenner M, Costantini T, Santorelli J, Curry T, Wintz D, Biffl WL, Schaffer KB, Duncan TK, Barbaro C, Diaz G, Johnson A, Chinn J, Naaseh A, Leung A, Grabar C, Nahmias J. PMID: 34853885; PMCID: PMC8635318.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    22. Readmission after splenic salvage: How real is the risk? Surgery. 2022 05; 171(5):1417-1421. Santorelli JE, Costantini TW, Berndtson AE, Kobayashi L, Doucet JJ, Godat LN. PMID: 34857387.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. CHRFAM7A expression in mice increases resiliency after injury. Inflamm Res. 2022 Jan; 71(1):9-11. Costantini TW, Coimbra R, Weaver JL, Eliceiri BP. PMID: 34792616; PMCID: PMC8758545.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    24. Driving under the influence: a multi-center evaluation of vehicular crashes in the era of cannabis legalization. Trauma Surg Acute Care Open. 2021; 6(1):e000736. Borst JM, Costantini TW, Reilly L, Smith AM, Stabley R, Steele J, Wintz D, Bansal V, Biffl WL, Godat LN. PMID: 34786487; PMCID: PMC8587622.
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    25. Pelvic fracture-related hypotension: A review of contemporary adjuncts for hemorrhage control. J Trauma Acute Care Surg. 2021 10 01; 91(4):e93-e103. DuBose JJ, Burlew CC, Joseph B, Keville M, Harfouche M, Morrison J, Fox CJ, Mooney J, O'Toole R, Slobogean G, Marchand LS, Demetriades D, Werner NL, Benjamin E, Costantini T. PMID: 34238857.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. A tale of two centers: Is low-molecular-weight heparin really superior for prevention of posttraumatic venous thromboembolism? J Trauma Acute Care Surg. 2021 09 01; 91(3):537-541. Checchi KD, Costantini TW, Badiee J, Berndtson AE, Calvo RY, Rooney AS, Wessels LE, Prieto JM, Sise CB, Sise MJ, Martin MJ, Bansal V. PMID: 33901051.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26; 385(9):790-802. ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, Aday AW, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Costantini TW, de Brouwer S, Derde LPG, Detry MA, Duggal A, Džavík V, Effron MB, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Galanaud JP, Galen BT, Gandotra S, García-Madrona S, Girard TD, Godoy LC, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Hamburg NM, Haniffa R, Hanna G, Hanna N, Hegde SM, Hendrickson CM, Hite RD, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Hudock K, Hunt BJ, Husain M, Hyzy RC, Iyer VN, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski AL, King AJ, Knudson MM, Kornblith AE, Krishnan V, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Lima FG, Linstrum K, Litton E, Lopez-Sendon J, Lopez-Sendon Moreno JL, Lother SA, Malhotra S, Marcos M, Saud Marinez A, Marshall JC, Marten N, Matthay MA, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Moore SC, Morillo Guerrero R, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nunez-Garcia B, Pandey A, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pérez González YS, Pompilio M, Prekker ME, Quigley JG, Rost NS, Rowan K, Santos FO, Santos M, Olombrada Santos M, Satterwhite L, Saunders CT, Schutgens REG, Seymour CW, Siegal DM, Silva DG, Shankar-Hari M, Sheehan JP, Singhal AB, Solvason D, Stanworth SJ, Tritschler T, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Wells BJ, Widmer RJ, Wilson JG, Yuriditsky E, Zampieri FG, Angus DC, McArthur CJ, Webb SA, Farkouh ME, Hochman JS, Zarychanski R. PMID: 34351721; PMCID: PMC8362594.
      View in: PubMed   Mentions: 187     Fields:    Translation:Humans
    28. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26; 385(9):777-789. REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Džavík V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Gallego Lima F, Linstrum K, Litton E, Lopez-Sendon J, Lother SA, Marten N, Saud Marinez A, Martinez M, Mateos Garcia E, Mavromichalis S, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nicolau JC, Nunez-Garcia B, Park JJ, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pompilio M, Quigley JG, Rosenson RS, Rost NS, Rowan K, Santos FO, Santos M, Santos MO, Satterwhite L, Saunders CT, Schreiber J, Schutgens REG, Seymour CW, Siegal DM, Silva DG, Singhal AB, Slutsky AS, Solvason D, Stanworth SJ, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Widmer RJ, Wilson JG, Yuriditsky E, Zhong Y, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R. PMID: 34351722; PMCID: PMC8362592.
      View in: PubMed   Mentions: 198     Fields:    Translation:Humans
    29. Does Gender Matter: A Multi-Institutional Analysis of Viscoelastic Profiles for 1565 Trauma Patients With Severe Hemorrhage. Am Surg. 2022 Mar; 88(3):512-518. Smith A, Duchesne J, Marturano M, Lawicki S, Sexton K, Taylor JR, Richards J, Harris C, Moreno-Ponte O, Cannon JW, Guzman JF, Pickett ML, Cripps MW, Curry T, Costantini T, Guidry C. PMID: 34266290.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Methamphetamine Use is Associated with Increased Surgical Site Infections after Trauma Laparotomy. J Surg Res. 2021 11; 267:563-567. Weaver JL, Berndtson AE, Lee J, Kobayashi L, Doucet J, Godat L, Costantini TW, Higginson S. PMID: 34261007.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Drug and alcohol positivity of traumatically injured patients related to COVID-19 stay-at-home orders. Am J Drug Alcohol Abuse. 2021 09 03; 47(5):605-611. Young KN, Yeates EO, Grigorian A, Schellenberg M, Owattanapanich N, Barmparas G, Margulies D, Juillard C, Garber K, Cryer H, Tillou A, Burruss S, Penaloza-Villalobos L, Lin A, Figueras RA, Brenner M, Firek C, Costantini T, Santorelli J, Curry T, Wintz D, Biffl WL, Schaffer KB, Duncan TK, Barbaro C, Diaz G, Johnson A, Chinn J, Naaseh A, Leung A, Grabar C, Nahmias J. PMID: 34087086.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsPHPublic Health
    32. COVID-19 in trauma: a propensity-matched analysis of COVID and non-COVID trauma patients. Eur J Trauma Emerg Surg. 2021 Oct; 47(5):1335-1342. Yeates EO, Grigorian A, Schellenberg M, Owattanapanich N, Barmparas G, Margulies D, Juillard C, Garber K, Cryer H, Tillou A, Burruss S, Figueras RA, Mladenov G, Brenner M, Firek C, Costantini T, Santorelli J, Curry T, Wintz D, Biffl WL, Schaffer KB, Duncan TK, Barbaro C, Diaz G, Johnson A, Chinn J, Naaseh A, Leung A, Grabar C, Nahmias J. PMID: 34031703; PMCID: PMC8143988.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    33. Restart TICrH: An Adaptive Randomized Trial of Time Intervals to Restart Direct Oral Anticoagulants after Traumatic Intracranial Hemorrhage. J Neurotrauma. 2021 06 01; 38(13):1791-1798. Milling TJ, Warach S, Johnston SC, Gajewski B, Costantini T, Price M, Wick J, Roward S, Mudaranthakam D, Dula AN, King B, Muddiman A, Lip GYH. PMID: 33470152; PMCID: PMC8219199.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Changes in traumatic mechanisms of injury in Southern California related to COVID-19: Penetrating trauma as a second pandemic. J Trauma Acute Care Surg. 2021 04 01; 90(4):714-721. Yeates EO, Grigorian A, Barrios C, Schellenberg M, Owattanapanich N, Barmparas G, Margulies D, Juillard C, Garber K, Cryer H, Tillou A, Burruss S, Penaloza-Villalobos L, Lin A, Figueras RA, Brenner M, Firek C, Costantini T, Santorelli J, Curry T, Wintz D, Biffl WL, Schaffer KB, Duncan TK, Barbaro C, Diaz G, Johnson A, Chinn J, Naaseh A, Leung A, Grabar C, Nahmias J. PMID: 33395031; PMCID: PMC7996056.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCellsPHPublic Health
    35. Enhancing trauma registries by integrating traffic records and geospatial analysis to improve bicyclist safety. J Trauma Acute Care Surg. 2021 04 01; 90(4):631-640. Doucet JJ, Godat LN, Kobayashi L, Berndtson AE, Liepert AE, Raschke E, Denny JW, Weaver J, Smith A, Costantini T. PMID: 33443983.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Repeat head computed tomography for anticoagulated patients with an initial negative scan is not cost-effective. Surgery. 2021 08; 170(2):623-627. Borst J, Godat LN, Berndtson AE, Kobayashi L, Doucet JJ, Costantini TW. PMID: 33781587.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. The coronavirus disease 2019 (COVID-19) stay-at-home order's unequal effects on trauma volume by insurance status in Southern California. Surgery. 2021 09; 170(3):962-968. Yeates EO, Juillard C, Grigorian A, Schellenberg M, Owattanapanich N, Barmparas G, Margulies D, Garber K, Cryer H, Tillou A, Burruss S, Penaloza-Villalobos L, Lin A, Figueras RA, Brenner M, Firek C, Costantini T, Santorelli J, Curry T, Wintz D, Biffl WL, Schaffer KB, Duncan TK, Barbaro C, Diaz G, Johnson A, Chinn J, Naaseh A, Leung A, Grabar C, Yeates TO, Nahmias J. PMID: 33849732.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    38. Restarting and timing of oral anticoagulation after traumatic intracranial hemorrhage: a review and summary of ongoing and planned prospective randomized clinical trials. Trauma Surg Acute Care Open. 2020; 5(1):e000605. King B, Milling T, Gajewski B, Costantini TW, Wick J, Price MA, Mudaranthakam D, Stein DM, Connolly S, Valadka A, Warach S. PMID: 33313417; PMCID: PMC7716676.
      View in: PubMed   Mentions:
    39. Emergency General Surgery and the Gallbladder: The Affordable Care Act's Impact on Practice Patterns. J Surg Res. 2021 01; 257:356-362. Godat LN, Costantini TW, Doucet JJ. PMID: 32892131.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    40. CHRFAM7A reduces monocyte/macrophage migration and colony formation in vitro. Inflamm Res. 2020 Jul; 69(7):631-633. Chan TW, Langness S, Cohen O, Eliceiri BP, Baird A, Costantini TW. PMID: 32303780; PMCID: PMC7263946.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    41. ECRG4 regulates neutrophil recruitment and CD44 expression during the inflammatory response to injury. Sci Adv. 2020 03; 6(11):eaay0518. Dorschner RA, Lee J, Cohen O, Costantini T, Baird A, Eliceiri BP. PMID: 32195341; PMCID: PMC7065879.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    42. The Effects of Cross-Border Transport on Patients With Tibia Fractures. J Surg Res. 2020 05; 249:91-98. Brito A, Godat LN, Costantini TW, Smith AM, Doucet JJ, Berndtson AE. PMID: 31926401.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Electrical stimulation of the vagus nerve improves intestinal blood flow after trauma and hemorrhagic shock. Surgery. 2020 03; 167(3):638-645. Yagi M, Morishita K, Ueno A, Nakamura H, Akabori H, Senda A, Kojima M, Aiboshi J, Costantini T, Coimbra R, Otomo Y. PMID: 31759624.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    44. Outcomes in patients with gunshot wounds to the brain. Trauma Surg Acute Care Open. 2019; 4(1):e000351. Robinson LA, Turco LM, Robinson B, Corsa JG, Mount M, Hamrick AV, Berne J, Mederos DR, McNickle AG, Chestovich PJ, Weinberger J, Grigorian A, Nahmias J, Lee JK, Chow KL, Olson EJ, Pascual JL, Solomon R, Pigneri DA, Ladhani HA, Fraifogl J, Claridge J, Curry T, Costantini TW, Kongwibulwut M, Kaafarani H, San Roman J, Schreiber C, Goldenberg-Sandau A, Hu P, Bosarge P, Uhlich R, Lunardi N, Usmani F, Sakran JV, Babcock JM, Quispe JC, Lottenberg L, Cabral D, Chang G, Gulmatico J, Parks JJ, Rattan R, Massetti J, Gurney O, Bruns B, Smith AA, Guidry C, Kutcher ME, Logan MS, Kincaid MY, Spalding C, Noorbaksh M, Philp FH, Cragun B, Winfield RD. PMID: 31799416; PMCID: PMC6861103.
      View in: PubMed   Mentions: 1  
    45. Risk Factors for Urinary Tract Infection or Pneumonia After Admission for Traumatic Subdural Hematoma at a Level I Trauma Center: Large Single-Institution Series. World Neurosurg. 2020 Feb; 134:e754-e760. Pham TB, Srinivas S, Martin JR, Brandel MG, Wali AR, Rennert RC, Steinberg JA, Santiago-Dieppa DR, Costantini TW, Khalessi AA. PMID: 31712113.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    46. Ultrasound-guided percutaneous intercostal nerve cryoneurolysis for analgesia following traumatic rib fracture -a case series. Korean J Anesthesiol. 2020 10; 73(5):455-459. Finneran Iv JJ, Gabriel RA, Swisher MW, Berndtson AE, Godat LN, Costantini TW, Ilfeld BM. PMID: 31684715; PMCID: PMC7533180.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    47. Who's being left behind? Uninsured emergency general surgery admissions after the ACA. Am J Surg. 2019 12; 218(6):1102-1109. Albini PT, Cochran-Yu MR, Godat LN, Costantini TW, Doucet JJ. PMID: 31607385.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    48. A Platform to Study the Effects of Electrical Stimulation on Immune Cell Activation During Wound Healing. Adv Biosyst. 2019 10; 3(10):e1900106. Wang K, Parekh U, Ting JK, Yamamoto NAD, Zhu J, Costantini T, Arias AC, Eliceiri BP, Ng TN. PMID: 32648726.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    49. Readmissions After Acute Hospitalization for Traumatic Brain Injury. J Surg Res. 2019 12; 244:332-337. Brito A, Costantini TW, Berndtson AE, Smith A, Doucet JJ, Godat LN. PMID: 31306890.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    50. The effect of hemorrhage control adjuncts on outcome in severe pelvic fracture: A multi-institutional study. J Trauma Acute Care Surg. 2019 Jul; 87(1):117-124. Duchesne J, Costantini TW, Khan M, Taub E, Rhee P, Morse B, Namias N, Schwarz A, Graves J, Kim DY, Howell E, Sperry J, Anto V, Winfield RD, Schreiber M, Behrens B, Martinez B, Raza S, Seamon M, Tatum D. PMID: 31260426.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    51. Respect your elders: effects of ageing on intracranial pressure monitor use in traumatic brain injury. Trauma Surg Acute Care Open. 2019; 4(1):e000306. Schupper AJ, Berndtson AE, Smith A, Godat L, Costantini TW. PMID: 31321312; PMCID: PMC6598557.
      View in: PubMed   Mentions: 2  
    52. Open reading frame mining identifies a TLR4 binding domain in the primary sequence of ECRG4. Cell Mol Life Sci. 2019 Dec; 76(24):5027-5039. Dang X, Coimbra R, Mao L, Podvin S, Li X, Yu H, Costantini TW, Zeng X, Larocca D, Eliceiri BP, Baird A. PMID: 31190084.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    53. Cross-border antibiotic resistance patterns in trauma patients. Surgery. 2019 07; 166(1):109-115. Berndtson AE, Bricker-Ford R, Box K, Madsen GZ, Malany L, Smith AM, Costantini TW, Coimbra R. PMID: 31072667.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    54. Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response. Proc Natl Acad Sci U S A. 2019 04 16; 116(16):7932-7940. Costantini TW, Chan TW, Cohen O, Langness S, Treadwell S, Williams E, Eliceiri BP, Baird A. PMID: 30944217; PMCID: PMC6475388.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    55. Anti-Xa guided enoxaparin dose adjustment improves pharmacologic deep venous thrombosis prophylaxis in burn patients. Burns. 2019 06; 45(4):818-824. Cronin BJ, Godat LN, Berndtson AE, Pham A, Kolan S, Box K, Lee JG, Costantini TW. PMID: 30827851.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    56. TBC1D3 regulates the payload and biological activity of extracellular vesicles that mediate tissue repair. FASEB J. 2019 05; 33(5):6129-6139. Qin S, Dorschner RA, Masini I, Lavoie-Gagne O, Stahl PD, Costantini TW, Baird A, Eliceiri BP. PMID: 30715917; PMCID: PMC6463925.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    57. Precious cargo: Modulation of the mesenteric lymph exosome payload after hemorrhagic shock. J Trauma Acute Care Surg. 2019 01; 86(1):52-61. Williams EC, Coimbra R, Chan TW, Baird A, Eliceiri BP, Costantini TW. PMID: 30576304; PMCID: PMC7265989.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    58. Impact of the Affordable Care Act on elective general surgery clinical practice. Am J Surg. 2019 06; 217(6):1055-1059. Yuen L, Costantini TW, Coimbra R, Godat LN. PMID: 30448210.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    59. Risk Factors for Venous Thromboembolism After Admission for Traumatic Subdural Hematoma at Level I Trauma Center: Large Single-Institution Series. World Neurosurg. 2019 02; 122:e619-e626. Rennert RC, Martin JR, Brandel MG, Steinberg JA, Santiago-Dieppa DR, Wali AR, Costantini TW, Khalessi AA. PMID: 31108078.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    60. CHRFAM7A alters binding to the neuronal alpha-7 nicotinic acetylcholine receptor. Neurosci Lett. 2019 01 18; 690:126-131. Chan T, Williams E, Cohen O, Eliceiri BP, Baird A, Costantini TW. PMID: 30308236; PMCID: PMC6320298.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    61. Implementation of a National Trauma Research Action Plan (NTRAP). J Trauma Acute Care Surg. 2018 06; 84(6):1012-1016. Bulger EM, Rasmussen TE, Jurkovich GJ, Fabian TC, Kozar RA, Coimbra R, Costantini TW, Ficke J, Malhotra AK, Price MA, Smith SL, Cioffi WG, Stewart RM. PMID: 29370052.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    62. The Use of Solicited Publishing by Academic Surgeons. Surgery. 2018 08; 164(2):212-218. Nguyen V, Marmor RA, Ramamoorthy SL, Costantini TW, Baumgartner JM, Berumen J, Jacobsen GR, Sicklick JK. PMID: 29724409; PMCID: PMC6074048.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    63. Gut epithelial cell-derived exosomes trigger posttrauma immune dysfunction. J Trauma Acute Care Surg. 2018 02; 84(2):257-264. Kojima M, Costantini TW, Eliceiri BP, Chan TW, Baird A, Coimbra R. PMID: 29194317.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    64. Prophylactic enoxaparin doses may be inadequate in patients undergoing abdominal cancer surgery. J Surg Res. 2018 01; 221:183-189. Baumgartner JM, McKenzie S, Block S, Costantini TW, Lowy AM. PMID: 29229126.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    65. Exosomes in postshock mesenteric lymph are key mediators of acute lung injury triggering the macrophage activation via Toll-like receptor 4. FASEB J. 2018 01; 32(1):97-110. Kojima M, Gimenes-Junior JA, Chan TW, Eliceiri BP, Baird A, Costantini TW, Coimbra R. PMID: 28855278.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    66. Pelvic fracture pattern predicts the need for hemorrhage control intervention-Results of an AAST multi-institutional study. J Trauma Acute Care Surg. 2017 06; 82(6):1030-1038. Costantini TW, Coimbra R, Holcomb JB, Podbielski JM, Catalano RD, Blackburn A, Scalea TM, Stein DM, Williams L, Conflitti J, Keeney S, Hoey C, Zhou T, Sperry J, Skiada D, Inaba K, Williams BH, Minei JP, Privette A, Mackersie RC, Robinson BR, Moore FO, AAST Pelvic Fracture Study Group. PMID: 28520685.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    67. Analysis of Surfing Injuries Presenting in the Acute Trauma Setting. Ann Plast Surg. 2017 May; 78(5 Suppl 4):S233-S237. Jubbal KT, Chen C, Costantini T, Herrera F, Dobke M, Suliman A. PMID: 28301362.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    68. Enteric glia cells are critical to limiting the intestinal inflammatory response after injury. Am J Physiol Gastrointest Liver Physiol. 2017 Mar 01; 312(3):G274-G282. Langness S, Kojima M, Coimbra R, Eliceiri BP, Costantini TW. PMID: 28082286.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    69. Exosomes, not protein or lipids, in mesenteric lymph activate inflammation: Unlocking the mystery of post-shock multiple organ failure. J Trauma Acute Care Surg. 2017 01; 82(1):42-50. Kojima M, Gimenes-Junior JA, Langness S, Morishita K, Lavoie-Gagne O, Eliceiri B, Costantini TW, Coimbra R. PMID: 27779585.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    70. Modulating the Biologic Activity of Mesenteric Lymph after Traumatic Shock Decreases Systemic Inflammation and End Organ Injury. PLoS One. 2016; 11(12):e0168322. Langness S, Costantini TW, Morishita K, Eliceiri BP, Coimbra R. PMID: 27977787; PMCID: PMC5158049.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    71. If some is good, more is better: An enoxaparin dosing strategy to improve pharmacologic venous thromboembolism prophylaxis. J Trauma Acute Care Surg. 2016 12; 81(6):1095-1100. Berndtson AE, Costantini TW, Lane J, Box K, Coimbra R. PMID: 27244575.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    72. Mice engrafted with human hematopoietic stem cells support a human myeloid cell inflammatory response in vivo. Wound Repair Regen. 2016 11; 24(6):1004-1014. Baird A, Deng C, Eliceiri MH, Haghi F, Dang X, Coimbra R, Costantini TW, Torbett BE, Eliceiri BP. PMID: 27663454; PMCID: PMC5161601.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    73. Does sex matter? Effects on venous thromboembolism risk in screened trauma patients. J Trauma Acute Care Surg. 2016 09; 81(3):493-9. Berndtson AE, Costantini TW, Smith AM, Kobayashi L, Coimbra R. PMID: 27280942.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    74. Lost your nerve? Modulating the parasympathetic nervous system to treat inflammatory bowel disease. J Physiol. 2016 08 01; 594(15):4097-8. Costantini TW, Baird A. PMID: 27477606; PMCID: PMC4967743.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    75. Abdominal vascular trauma. Trauma Surg Acute Care Open. 2016; 1(1):e000015. Kobayashi LM, Costantini TW, Hamel MG, Dierksheide JE, Coimbra R. PMID: 29766059; PMCID: PMC5891707.
      View in: PubMed   Mentions: 8  
    76. Isolated traumatic brain injury in patients with cirrhosis: do different treatment paradigms result in increased mortality? Am J Surg. 2017 Jan; 213(1):80-86. Langness S, Costantini TW, Smith A, Bansal V, Coimbra R. PMID: 27421188.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    77. Current management of hemorrhage from severe pelvic fractures: Results of an American Association for the Surgery of Trauma multi-institutional trial. J Trauma Acute Care Surg. 2016 May; 80(5):717-23; discussion 723-5. Costantini TW, Coimbra R, Holcomb JB, Podbielski JM, Catalano R, Blackburn A, Scalea TM, Stein DM, Williams L, Conflitti J, Keeney S, Suleiman G, Zhou T, Sperry J, Skiada D, Inaba K, Williams BH, Minei JP, Privette A, Mackersie RC, Robinson BR, Moore FO, AAST Pelvic Fracture Study Group. PMID: 26958799.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    78. Injury, inflammation and the emergence of human-specific genes. Wound Repair Regen. 2016 05; 24(3):602-6. Baird A, Costantini T, Coimbra R, Eliceiri BP. PMID: 26874655; PMCID: PMC5021143.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    79. Up-regulation of the human-specific CHRFAM7A gene in inflammatory bowel disease. BBA Clin. 2016 Jun; 5:66-71. Baird A, Coimbra R, Dang X, Eliceiri BP, Costantini TW. PMID: 27051591; PMCID: PMC4802402.
      View in: PubMed   Mentions: 8  
    80. The Response to Burn Injury in Mice With Human Hematolymphoid Systems. Ann Surg. 2016 Jan; 263(1):199-204. Costantini TW, Meads M, Dang X, Coimbra R, Torbett BE, Baird A, Eliceiri BP. PMID: 25575256; PMCID: PMC6550477.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    81. Complexities of the Enteric Nervous System: In Reply to Fujita. J Am Coll Surg. 2016 Jan; 222(1):105-6. Langness S, Coimbra R, Costantini T. PMID: 26721758.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    82. Monitoring Neutrophil-Expressed Cell Surface Esophageal Cancer Related Gene-4 after Severe Burn Injury. Surg Infect (Larchmt). 2015 Dec; 16(6):669-74. Costantini TW, Coimbra R, Lopez NE, Lee JG, Potenza B, Smith A, Baird A, Eliceiri BP. PMID: 26460850; PMCID: PMC4663648.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    83. Vagus Nerve Mediates the Neural Stem Cell Response to Intestinal Injury. J Am Coll Surg. 2015 Oct; 221(4):871-9. Langness S, Coimbra R, Eliceiri BP, Costantini TW. PMID: 26209457.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    84. Neuroenteric axis modulates the balance of regulatory T cells and T-helper 17 cells in the mesenteric lymph node following trauma/hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 01; 309(3):G202-8. Morishita K, Coimbra R, Langness S, Eliceiri BP, Costantini TW. PMID: 26045612.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    85. A Human-Specific α7-Nicotinic Acetylcholine Receptor Gene in Human Leukocytes: Identification, Regulation and the Consequences of CHRFAM7A Expression. Mol Med. 2015 Apr 03; 21:323-36. Costantini TW, Dang X, Yurchyshyna MV, Coimbra R, Eliceiri BP, Baird A. PMID: 25860877; PMCID: PMC4534468.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    86. CHRFAM7A: a human-specific α7-nicotinic acetylcholine receptor gene shows differential responsiveness of human intestinal epithelial cells to LPS. FASEB J. 2015 Jun; 29(6):2292-302. Dang X, Eliceiri BP, Baird A, Costantini TW. PMID: 25681457; PMCID: PMC4763870.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    87. A pharmacologic approach to vagal nerve stimulation prevents mesenteric lymph toxicity after hemorrhagic shock. J Trauma Acute Care Surg. 2015 Jan; 78(1):52-8; discussion 58-9. Morishita K, Costantini TW, Ueno A, Bansal V, Eliceiri B, Coimbra R. PMID: 25539203.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    88. Esophageal cancer-related gene-4 (ECRG4) interactions with the innate immunity receptor complex. Inflamm Res. 2015 Feb; 64(2):107-18. Podvin S, Dang X, Meads M, Kurabi A, Costantini T, Eliceiri BP, Baird A, Coimbra R. PMID: 25511108; PMCID: PMC4301958.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    89. Pulmonary preconditioning, injury, and inflammation modulate expression of the candidate tumor suppressor gene ECRG4 in lung. Exp Lung Res. 2015 Apr; 41(3):162-72. Kao S, Shaterian A, Cauvi DM, Dang X, Chun HB, De Maio A, Costantini TW, Coimbra R, Eliceiri BP, Baird A. PMID: 25513848; PMCID: PMC4524537.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    90. CHRFAM7A, a human-specific and partially duplicated α7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury. J Leukoc Biol. 2015 Feb; 97(2):247-57. Costantini TW, Dang X, Coimbra R, Eliceiri BP, Baird A. PMID: 25473097; PMCID: PMC4304420.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    91. Altering leukocyte recruitment following traumatic brain injury with ghrelin therapy. J Trauma Acute Care Surg. 2014 Nov; 77(5):709-715. Lee J, Costantini TW, D'Mello R, Eliceiri BP, Coimbra R, Bansal V. PMID: 25494422.
      View in: PubMed   Mentions: 10     Fields:    
    92. The vagus nerve alters the pulmonary dendritic cell response to injury. J Surg Res. 2014 Nov; 192(1):12-8. Lowry DM, Morishita K, Eliceiri BP, Bansal V, Coimbra R, Costantini TW. PMID: 25005822.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    93. Cholinergic signaling in the gut: a novel mechanism of barrier protection through activation of enteric glia cells. Surg Infect (Larchmt). 2014 Aug; 15(4):387-93. Cheadle GA, Costantini TW, Bansal V, Eliceiri BP, Coimbra R. PMID: 24828283.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    94. Vagal nerve stimulation modulates the dendritic cell profile in posthemorrhagic shock mesenteric lymph. J Trauma Acute Care Surg. 2014 Mar; 76(3):610-7; discussion 617-8. Morishita K, Costantini TW, Eliceiri B, Bansal V, Coimbra R. PMID: 24553526.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    95. Esophageal cancer-related gene 4 at the interface of injury, inflammation, infection, and malignancy. Gastrointest Cancer. 2014; 2014(4):131-142. Baird A, Lee J, Podvin S, Kurabi A, Dang X, Coimbra R, Costantini T, Bansal V, Eliceiri BP. PMID: 25580077; PMCID: PMC4287990.
      View in: PubMed   Mentions: 15  
    96. Abdominal damage control surgery and reconstruction: world society of emergency surgery position paper. World J Emerg Surg. 2013 Dec 17; 8(1):53. Godat L, Kobayashi L, Costantini T, Coimbra R. PMID: 24341602; PMCID: PMC3878509.
      View in: PubMed   Mentions: 34     Fields:    
    97. Enteric glia cells attenuate cytomix-induced intestinal epithelial barrier breakdown. PLoS One. 2013; 8(7):e69042. Cheadle GA, Costantini TW, Lopez N, Bansal V, Eliceiri BP, Coimbra R. PMID: 23840906; PMCID: PMC3698076.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    98. Vagal nerve stimulation protects cardiac injury by attenuating mitochondrial dysfunction in a murine burn injury model. J Cell Mol Med. 2013 May; 17(5):664-71. Lu X, Costantini T, Lopez NE, Wolf PL, Hageny AM, Putnam J, Eliceiri B, Coimbra R. PMID: 23577721; PMCID: PMC3822819.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    99. Limb salvage after complex repairs of extremity arterial injuries is independent of surgical specialty training. J Trauma Acute Care Surg. 2013 Mar; 74(3):716-23; discussion 723-4. Shackford SR, Kahl JE, Calvo RY, Shackford MC, Danos LA, Davis JW, Vercruysse GA, Feliciano DV, Moore EE, Moore HB, Knudson MM, Howard BM, Sise MJ, Coimbra RS, Costantini TW, Brakenridge SC, Tominaga GT, Schaffer KB, Steele JT, Kennedy FR, Cogbill TH. PMID: 23425727.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    100. Uncovering the neuroenteric-pulmonary axis: vagal nerve stimulation prevents acute lung injury following hemorrhagic shock. Life Sci. 2013 Apr 19; 92(13):783-92. Reys LG, Ortiz-Pomales YT, Lopez N, Cheadle G, de Oliveira PG, Eliceiri B, Bansal V, Costantini TW, Coimbra R. PMID: 23439327.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    101. Dose adjusting enoxaparin is necessary to achieve adequate venous thromboembolism prophylaxis in trauma patients. J Trauma Acute Care Surg. 2013 Jan; 74(1):128-33; discussion 134-5. Costantini TW, Min E, Box K, Tran V, Winfield RD, Fortlage D, Doucet J, Bansal V, Coimbra R. PMID: 23271087; PMCID: PMC4010946.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    102. Hypovolemic shock resuscitation. Surg Clin North Am. 2012 Dec; 92(6):1403-23. Kobayashi L, Costantini TW, Coimbra R. PMID: 23153876.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    103. Intravenous phage display identifies peptide sequences that target the burn-injured intestine. Peptides. 2012 Nov; 38(1):94-9. Costantini TW, Eliceiri BP, Putnam JG, Bansal V, Baird A, Coimbra R. PMID: 22960048; PMCID: PMC4524536.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    104. Vagal nerve stimulation blocks peritoneal macrophage inflammatory responsiveness after severe burn injury. Shock. 2012 Aug; 38(3):294-300. Lopez NE, Krzyzaniak M, Costantini TW, De Maio A, Baird A, Eliceiri BP, Coimbra R. PMID: 22683732; PMCID: PMC3422402.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    105. Syndecan 1 plays a novel role in enteral glutamine's gut-protective effects of the postischemic gut. Shock. 2012 Jul; 38(1):57-62. Peng Z, Ban K, Sen A, Grill R, Park P, Costantini TW, Kozar R. PMID: 22706022; PMCID: PMC3391586.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    106. Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury. Am J Pathol. 2012 Aug; 181(2):478-86. Costantini TW, Krzyzaniak M, Cheadle GA, Putnam JG, Hageny AM, Lopez N, Eliceiri BP, Bansal V, Coimbra R. PMID: 22688057.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    107. Vagal nerve stimulation decreases blood-brain barrier disruption after traumatic brain injury. J Trauma Acute Care Surg. 2012 Jun; 72(6):1562-6. Lopez NE, Krzyzaniak MJ, Costantini TW, Putnam J, Hageny AM, Eliceiri B, Coimbra R, Bansal V. PMID: 22695423.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    108. Is contrast exposure safe among the highest risk trauma patients? J Trauma Acute Care Surg. 2012 Jan; 72(1):61-6; discussion 66-7. Kim DY, Kobayashi L, Costantini TW, Chang D, Fortlage D, Curry T, Wynn S, Doucet J, Bansal V, Coimbra R. PMID: 22310117.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    109. Arterial embolization for pelvic fractures after blunt trauma: are we all talk? Am J Surg. 2010 Dec; 200(6):752-7; discussion 757-8. Costantini TW, Bosarge PL, Fortlage D, Bansal V, Coimbra R. PMID: 21146016.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    110. The hormone ghrelin prevents traumatic brain injury induced intestinal dysfunction. J Neurotrauma. 2010 Dec; 27(12):2255-60. Bansal V, Ryu SY, Blow C, Costantini T, Loomis W, Eliceiri B, Baird A, Wolf P, Coimbra R. PMID: 20858122; PMCID: PMC3304249.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    111. Tumor necrosis factor expression is ameliorated after exposure to an acidic environment. J Surg Res. 2012 Mar; 173(1):127-34. Grabowski J, Vazquez DE, Costantini T, Cauvi DM, Charles W, Bickler S, Talamini MA, Vega VL, Coimbra R, De Maio A. PMID: 20888586; PMCID: PMC3017641.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    112. Vagal nerve stimulation protects against burn-induced intestinal injury through activation of enteric glia cells. Am J Physiol Gastrointest Liver Physiol. 2010 Dec; 299(6):G1308-18. Costantini TW, Bansal V, Krzyzaniak M, Putnam JG, Peterson CY, Loomis WH, Wolf P, Baird A, Eliceiri BP, Coimbra R. PMID: 20705905; PMCID: PMC3774266.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    113. Efferent vagal nerve stimulation attenuates gut barrier injury after burn: modulation of intestinal occludin expression. J Trauma. 2010 Jun; 68(6):1349-54; discussion 1354-6. Costantini TW, Bansal V, Peterson CY, Loomis WH, Putnam JG, Rankin F, Wolf P, Eliceiri BP, Baird A, Coimbra R. PMID: 20539179; PMCID: PMC4251593.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    114. A novel fluid resuscitation strategy modulates pulmonary transcription factor activation in a murine model of hemorrhagic shock. Clinics (Sao Paulo). 2010 Jun; 65(6):621-8. Costantini TW, Deree J, Martins JO, Putnam JG, Campos Td, Coimbra R. PMID: 20613939; PMCID: PMC2898548.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    115. Stimulating the central nervous system to prevent intestinal dysfunction after traumatic brain injury. J Trauma. 2010 May; 68(5):1059-64. Bansal V, Costantini T, Ryu SY, Peterson C, Loomis W, Putnam J, Elicieri B, Baird A, Coimbra R. PMID: 20453760; PMCID: PMC4251579.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    116. Concentration of arginine and optimal time of hypertonic saline in restoration of T-cell dysfunction. J Surg Res. 2010 Sep; 163(1):e17-22. Moon SW, Choi SH, Cho HJ, Yun YH, Kim JY, Hong YS, Costantini T, Bansal V. PMID: 20599217.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    117. Toll-like receptor-4 mediates intestinal barrier breakdown after thermal injury. Surg Infect (Larchmt). 2010 Apr; 11(2):137-44. Peterson CY, Costantini TW, Loomis WH, Putnam JG, Wolf P, Bansal V, Eliceiri BP, Baird A, Coimbra R. PMID: 20374005; PMCID: PMC3304242.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    118. Pentoxifylline modulates p47phox activation and downregulates neutrophil oxidative burst through PKA-dependent and -independent mechanisms. Immunopharmacol Immunotoxicol. 2010 Mar; 32(1):82-91. Costantini TW, Deree J, Peterson CY, Putnam JG, Woon T, Loomis WH, Bansal V, Coimbra R. PMID: 19839729.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    119. Children at danger: injury fatalities among children in San Diego County. Eur J Epidemiol. 2010 Mar; 25(3):211-7. Fraga AM, Fraga GP, Stanley C, Costantini TW, Coimbra R. PMID: 20084430; PMCID: PMC2836467.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    120. Pentoxifylline attenuates leukoreduced stored blood-induced neutrophil activation through inhibition of mitogen-activated protein kinases. Immunopharmacol Immunotoxicol. 2010 Mar; 32(1):74-81. Costantini TW, Deree J, Martins JO, Loomis WH, Bansal V, Coimbra R. PMID: 19697996.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    121. Quantitative assessment of intestinal injury using a novel in vivo, near-infrared imaging technique. Mol Imaging. 2010 Feb; 9(1):30-9. Costantini TW, Eliceiri BP, Peterson CY, Loomis WH, Putnam JG, Baird A, Wolf P, Bansal V, Coimbra R. PMID: 20128996; PMCID: PMC4241240.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    122. Burns, inflammation, and intestinal injury: protective effects of an anti-inflammatory resuscitation strategy. J Trauma. 2009 Dec; 67(6):1162-8. Costantini TW, Peterson CY, Kroll L, Loomis WH, Putnam JG, Wolf P, Eliceiri BP, Baird A, Bansal V, Coimbra R. PMID: 20009662; PMCID: PMC4251580.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    123. Redefining renal dysfunction in trauma: implementation of the Acute Kidney Injury Network staging system. J Trauma. 2009 Aug; 67(2):283-7; discussion 287-8. Costantini TW, Fraga G, Fortlage D, Wynn S, Fraga A, Lee J, Doucet J, Bansal V, Coimbra R. PMID: 19667880.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    124. Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis. J Neurotrauma. 2009 Aug; 26(8):1353-9. Bansal V, Costantini T, Kroll L, Peterson C, Loomis W, Eliceiri B, Baird A, Wolf P, Coimbra R. PMID: 19344293; PMCID: PMC2989839.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    125. Targeting the gut barrier: identification of a homing peptide sequence for delivery into the injured intestinal epithelial cell. Surgery. 2009 Aug; 146(2):206-12. Costantini TW, Putnam JG, Sawada R, Baird A, Loomis WH, Eliceiri BP, Bansal V, Coimbra R. PMID: 19628075; PMCID: PMC4251594.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    126. Real-time analysis of the kinetics of angiogenesis and vascular permeability in an animal model of wound healing. Burns. 2009 Sep; 35(6):811-7. Shaterian A, Borboa A, Sawada R, Costantini T, Potenza B, Coimbra R, Baird A, Eliceiri BP. PMID: 19423227; PMCID: PMC2739287.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    127. Role of p38 MAPK in burn-induced intestinal barrier breakdown. J Surg Res. 2009 Sep; 156(1):64-9. Costantini TW, Peterson CY, Kroll L, Loomis WH, Eliceiri BP, Baird A, Bansal V, Coimbra R. PMID: 19577248; PMCID: PMC4251589.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    128. Arginine is essential in reversing prostaglandin E(2) T-cell suppression by hypertonic saline. J Surg Res. 2009 Sep; 156(1):83-9. Choi SH, Bansal V, Costantini T, Putnam J, Loomis W, Coimbra R. PMID: 19577247.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    129. Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins. Shock. 2009 Apr; 31(4):416-22. Costantini TW, Loomis WH, Putnam JG, Drusinsky D, Deree J, Choi S, Wolf P, Baird A, Eliceiri B, Bansal V, Coimbra R. PMID: 18791495; PMCID: PMC3445035.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    130. Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase. J Trauma. 2009 Jan; 66(1):17-24; discussion 24-5. Costantini TW, Loomis WH, Putnam JG, Kroll L, Eliceiri BP, Baird A, Bansal V, Coimbra R. PMID: 19131801; PMCID: PMC4251583.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    131. Acute lower GI bleeding for the acute care surgeon: current diagnosis and management. Scand J Surg. 2009; 98(3):135-42. Lee J, Costantini TW, Coimbra R. PMID: 19919917.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    132. Hemorrhage is More Prevalent than Brain Injury in Early Trauma Deaths: The Golden Six Hours. Eur J Trauma Emerg Surg. 2009 Feb; 35(1):26-30. Bansal V, Fortlage D, Lee JG, Costantini T, Potenza B, Coimbra R. PMID: 26814527.
      View in: PubMed   Mentions: 21     Fields:    
    133. Phosphodiesterase inhibition attenuates alterations to the tight junction proteins occludin and ZO-1 in immunostimulated Caco-2 intestinal monolayers. Life Sci. 2009 Jan 02; 84(1-2):18-22. Costantini TW, Deree J, Loomis W, Putnam JG, Choi S, Baird A, Eliceiri BP, Bansal V, Coimbra R. PMID: 18992758.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    134. Surgical resident and attending physician attitudes toward glucose control in the surgical patient. Am Surg. 2008 Oct; 74(10):993-6. Costantini TW, Acosta JA, Hoyt DB, Ramamoorthy S. PMID: 18942630.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    135. Abdominal complications of ventricular assist device placement. Surg Infect (Larchmt). 2005; 6(4):409-18. Costantini TW, Taylor JH, Beilman GJ. PMID: 16433605.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
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