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    Todd Costantini

    Address200 W. Arbor Drive #8896
    CA San Diego 92103
    Phone619-543-7107
    vCardDownload vCard

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      Todd W. Costantini, MD is currently an Assistant Professor of Surgery in the Division of Trauma, Surgical Critical Care, Burns and Acute Care Surgery at UC San Diego. Dr. Costantini is a graduate of the University of Minnesota Medical School. He completed his General Surgery residency at UC-San Diego where he served as the Administrative Chief Resident during his final year of training. He went on to complete a fellowship in Trauma and Surgical Critical Care at UC-San Diego under the direction of Dr. Raul Coimbra. Dr. Costantini’s practice is focused on General Surgery, Trauma, and Surgical Critical Care.

      In addition to his clinical practice, Dr. Costantini has several active clinical and translational research projects ongoing. He is an investigator in the UC-San Diego Laboratories of Trauma, Surgical Critical Care, and Burn Research. In 2011, Dr. Costantini was awarded the American Association for the Surgery of Trauma (AAST) Research and Education Scholarship Award to fund his basic science research in preventing intestinal barrier failure after severe injury. His clinical research interests include improving DVT prophylaxis in Trauma and Surgery patients. He is also leading a multi-center study sponsored by the AAST to define management strategies for patients with hemorrhage from severe pelvic fractures.


      Collapse Research 
      Collapse Research Activities and Funding
      The Human-Specific Gene CHRFAM7A in Leukocytes
      NIH/NIGMS R01GM121530Apr 1, 2017 - Mar 31, 2022
      Role: Principal Investigator

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kojima M, Gimenes-Junior JA, Chan TW, Eliceiri BP, Baird A, Costantini T, Coimbra R. Exosomes in postshock mesenteric lymph are key mediators of acute lung injury triggering the macrophage activation via Toll-like receptor 4. FASEB J. 2017 Aug 29. PMID: 28855278.
        View in: PubMed
      2. Costantini T, Coimbra R, Holcomb JB, Podbielski JM, Catalano RD, Blackburn A, Scalea TM, Stein DM, Williams L, Conflitti J, Keeney S, Hoey C, Zhou T, Sperry J, Skiada D, Inaba K, Williams BH, Minei JP, Privette A, Mackersie RC, Robinson BR, Moore FO. Pelvic fracture pattern predicts the need for hemorrhage control intervention-Results of an AAST multi-institutional study. J Trauma Acute Care Surg. 2017 Jun; 82(6):1030-1038. PMID: 28520685.
        View in: PubMed
      3. Jubbal KT, Chen C, Costantini T, Herrera F, Dobke M, Suliman A. Analysis of Surfing Injuries Presenting in the Acute Trauma Setting. Ann Plast Surg. 2017 May; 78(5 Suppl 4):S233-S237. PMID: 28301362.
        View in: PubMed
      4. Costantini T, Coimbra R, Holcomb JB, Podbielski JM, Catalano R, Blackburn A, Scalea TM, Stein DM, Williams L, Conflitti J, Keeney S, Hoey C, Zhou T, Sperry J, Skiada D, Inaba K, Williams BH, Minei JP, Privette A, Mackersie RC, Robinson BR, Moore FO. Pelvic fracture pattern predicts the need for hemorrhage control intervention -- results of a AAST multi-institutional study. J Trauma Acute Care Surg. 2017 Mar 23. PMID: 28338600.
        View in: PubMed
      5. Langness S, Kojima M, Coimbra R, Eliceiri BP, Costantini T. Enteric Glia Cells are Critical to Limiting the Intestinal Inflammatory Response After Injury. Am J Physiol Gastrointest Liver Physiol. 2017 Jan 12; ajpgi.00371.2016. PMID: 28082286.
        View in: PubMed
      6. Kojima M, Gimenes-Junior JA, Langness S, Morishita K, Lavoie-Gagne O, Eliceiri B, Costantini T, Coimbra R. Exosomes, not protein or lipids, in mesenteric lymph activate inflammation: Unlocking the mystery of post-shock multiple organ failure. J Trauma Acute Care Surg. 2017 Jan; 82(1):42-50. PMID: 27779585.
        View in: PubMed
      7. Berndtson AE, Costantini T, Lane J, Box K, Coimbra R. If some is good, more is better: An enoxaparin dosing strategy to improve pharmacologic venous thromboembolism prophylaxis. J Trauma Acute Care Surg. 2016 Dec; 81(6):1095-1100. PMID: 27244575.
        View in: PubMed
      8. Baird A, Deng C, Eliceiri MH, Haghi F, Dang X, Coimbra R, Costantini T, Torbett BE, Eliceiri BP. Mice engrafted with human hematopoietic stem cells support a human myeloid cell inflammatory response in vivo. Wound Repair Regen. 2016 Sep 24. PMID: 27663454.
        View in: PubMed
      9. Berndtson AE, Costantini T, Smith AM, Kobayashi L, Coimbra R. Does sex matter? Effects on venous thromboembolism risk in screened trauma patients. J Trauma Acute Care Surg. 2016 Sep; 81(3):493-9. PMID: 27280942.
        View in: PubMed
      10. Langness S, Costantini T, Smith A, Bansal V, Coimbra R. Isolated traumatic brain injury in patients with cirrhosis: do different treatment paradigms result in increased mortality? Am J Surg. 2017 Jan; 213(1):80-86. PMID: 27421188.
        View in: PubMed
      11. Costantini T, Coimbra R, Holcomb JB, Podbielski JM, Catalano R, Blackburn A, Scalea TM, Stein DM, Williams L, Conflitti J, Keeney S, Suleiman G, Zhou T, Sperry J, Skiada D, Inaba K, Williams BH, Minei JP, Privette A, Mackersie RC, Robinson BR, Moore FO. Current management of hemorrhage from severe pelvic fractures: Results of an American Association for the Surgery of Trauma multi-institutional trial. J Trauma Acute Care Surg. 2016 May; 80(5):717-25. PMID: 26958799.
        View in: PubMed
      12. Baird A, Costantini T, Coimbra R, Eliceiri BP. Injury, inflammation and the emergence of human-specific genes. Wound Repair Regen. 2016 May; 24(3):602-6. PMID: 26874655.
        View in: PubMed
      13. Baird A, Coimbra R, Dang X, Eliceiri BP, Costantini T. Up-regulation of the human-specific CHRFAM7A gene in inflammatory bowel disease. BBA Clin. 2016 Jun; 5:66-71. PMID: 27051591.
        View in: PubMed
      14. Costantini T, Meads M, Dang X, Coimbra R, Torbett BE, Baird A, Eliceiri BP. The Response to Burn Injury in Mice With Human Hematolymphoid Systems. Ann Surg. 2016 Jan; 263(1):199-204. PMID: 25575256.
        View in: PubMed
      15. Costantini T, Coimbra R, Lopez NE, Lee JG, Potenza B, Smith A, Baird A, Eliceiri BP. Monitoring Neutrophil-Expressed Cell Surface Esophageal Cancer Related Gene-4 after Severe Burn Injury. Surg Infect (Larchmt). 2015 Dec; 16(6):669-74. PMID: 26460850.
        View in: PubMed
      16. Langness S, Coimbra R, Eliceiri BP, Costantini T. Vagus Nerve Mediates the Neural Stem Cell Response to Intestinal Injury. J Am Coll Surg. 2015 Oct; 221(4):871-9. PMID: 26209457.
        View in: PubMed
      17. Morishita K, Coimbra R, Langness S, Eliceiri BP, Costantini T. Neuroenteric axis modulates the balance of regulatory T cells and T-helper 17 cells in the mesenteric lymph node following trauma/hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 1; 309(3):G202-8. PMID: 26045612.
        View in: PubMed
      18. Costantini T, Dang X, Yurchyshyna MV, Coimbra R, Eliceiri BP, Baird A. A Human-Specific a7-Nicotinic Acetylcholine Receptor Gene in Human Leukocytes: Identification, Regulation and the Consequences of CHRFAM7A Expression. Mol Med. 2015; 21(1):323-36. PMID: 25860877.
        View in: PubMed
      19. Dang X, Eliceiri BP, Baird A, Costantini T. CHRFAM7A: a human-specific a7-nicotinic acetylcholine receptor gene shows differential responsiveness of human intestinal epithelial cells to LPS. FASEB J. 2015 Jun; 29(6):2292-302. PMID: 25681457.
        View in: PubMed
      20. Morishita K, Costantini T, Ueno A, Bansal V, Eliceiri B, Coimbra R. A pharmacologic approach to vagal nerve stimulation prevents mesenteric lymph toxicity after hemorrhagic shock. J Trauma Acute Care Surg. 2015 Jan; 78(1):52-9. PMID: 25539203.
        View in: PubMed
      21. Podvin S, Dang X, Meads M, Kurabi A, Costantini T, Eliceiri BP, Baird A, Coimbra R. Esophageal cancer-related gene-4 (ECRG4) interactions with the innate immunity receptor complex. Inflamm Res. 2015 Feb; 64(2):107-18. PMID: 25511108.
        View in: PubMed
      22. Kao S, Shaterian A, Cauvi DM, Dang X, Chun HB, De Maio A, Costantini T, Coimbra R, Eliceiri BP, Baird A. Pulmonary preconditioning, injury, and inflammation modulate expression of the candidate tumor suppressor gene ECRG4 in lung. Exp Lung Res. 2015 Apr; 41(3):162-72. PMID: 25513848.
        View in: PubMed
      23. Costantini T, Dang X, Coimbra R, Eliceiri BP, Baird A. CHRFAM7A, a human-specific and partially duplicated a7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury. J Leukoc Biol. 2015 Feb; 97(2):247-57. PMID: 25473097.
        View in: PubMed
      24. Lee J, Costantini T, D'Mello R, Eliceiri BP, Coimbra R, Bansal V. Altering leukocyte recruitment following traumatic brain injury with ghrelin therapy. J Trauma Acute Care Surg. 2014 Nov; 77(5):709-715. PMID: 25494422.
        View in: PubMed
      25. Lowry DM, Morishita K, Eliceiri BP, Bansal V, Coimbra R, Costantini T. The vagus nerve alters the pulmonary dendritic cell response to injury. J Surg Res. 2014 Nov; 192(1):12-8. PMID: 25005822.
        View in: PubMed
      26. Cheadle GA, Costantini T, Bansal V, Eliceiri BP, Coimbra R. Cholinergic Signaling in the Gut: A Novel Mechanism of Barrier Protection through Activation of Enteric Glia Cells. Surg Infect (Larchmt). 2014 Aug; 15(4):387-93. PMID: 24828283.
        View in: PubMed
      27. Morishita K, Costantini T, Eliceiri B, Bansal V, Coimbra R. Vagal nerve stimulation modulates the dendritic cell profile in posthemorrhagic shock mesenteric lymph. J Trauma Acute Care Surg. 2014 Mar; 76(3):610-8. PMID: 24553526.
        View in: PubMed
      28. Baird A, Lee J, Podvin S, Kurabi A, Dang X, Coimbra R, Costantini T, Bansal V, Eliceiri BP. Esophageal cancer-related gene 4 at the interface of injury, inflammation, infection, and malignancy. Gastrointest Cancer. 2014; 2014(4):131-142. PMID: 25580077.
        View in: PubMed
      29. Cheadle GA, Costantini T, Lopez N, Bansal V, Eliceiri BP, Coimbra R. Enteric glia cells attenuate cytomix-induced intestinal epithelial barrier breakdown. PLoS One. 2013; 8(7):e69042. PMID: 23840906.
        View in: PubMed
      30. Lu X, Costantini T, Lopez NE, Wolf PL, Hageny AM, Putnam J, Eliceiri B, Coimbra R. Vagal nerve stimulation protects cardiac injury by attenuating mitochondrial dysfunction in a murine burn injury model. J Cell Mol Med. 2013 May; 17(5):664-71. PMID: 23577721.
        View in: PubMed
      31. Costantini T, Min E, Box K, Tran V, Winfield RD, Fortlage D, Doucet J, Bansal V, Coimbra R. Dose adjusting enoxaparin is necessary to achieve adequate venous thromboembolism prophylaxis in trauma patients. J Trauma Acute Care Surg. 2013 Jan; 74(1):128-33; discussion 134-5. PMID: 23271087.
        View in: PubMed
      32. Kobayashi L, Costantini T, Coimbra R. Hypovolemic shock resuscitation. Surg Clin North Am. 2012 Dec; 92(6):1403-23. PMID: 23153876.
        View in: PubMed
      33. Costantini T, Eliceiri BP, Putnam JG, Bansal V, Baird A, Coimbra R. Intravenous phage display identifies peptide sequences that target the burn-injured intestine. Peptides. 2012 Nov; 38(1):94-9. PMID: 22960048.
        View in: PubMed
      34. Lopez NE, Krzyzaniak M, Costantini T, De Maio A, Baird A, Eliceiri BP, Coimbra R. Vagal nerve stimulation blocks peritoneal macrophage inflammatory responsiveness after severe burn injury. Shock. 2012 Aug; 38(3):294-300. PMID: 22683732.
        View in: PubMed
      35. Costantini T, Krzyzaniak M, Cheadle GA, Putnam JG, Hageny AM, Lopez N, Eliceiri BP, Bansal V, Coimbra R. Targeting a-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury. Am J Pathol. 2012 Aug; 181(2):478-86. PMID: 22688057.
        View in: PubMed
      36. Lopez NE, Krzyzaniak MJ, Costantini T, Putnam J, Hageny AM, Eliceiri B, Coimbra R, Bansal V. Vagal nerve stimulation decreases blood-brain barrier disruption after traumatic brain injury. J Trauma Acute Care Surg. 2012 Jun; 72(6):1562-6. PMID: 22695423.
        View in: PubMed
      37. Kim DY, Kobayashi L, Costantini T, Chang D, Fortlage D, Curry T, Wynn S, Doucet J, Bansal V, Coimbra R. Is contrast exposure safe among the highest risk trauma patients? J Trauma Acute Care Surg. 2012 Jan; 72(1):61-6; discussion 66-7. PMID: 22310117.
        View in: PubMed
      38. Costantini T, Bosarge PL, Fortlage D, Bansal V, Coimbra R. Arterial embolization for pelvic fractures after blunt trauma: are we all talk? Am J Surg. 2010 Dec; 200(6):752-7; discussion 757-8. PMID: 21146016.
        View in: PubMed
      39. Bansal V, Ryu SY, Blow C, Costantini T, Loomis W, Eliceiri B, Baird A, Wolf P, Coimbra R. The hormone ghrelin prevents traumatic brain injury induced intestinal dysfunction. J Neurotrauma. 2010 Dec; 27(12):2255-60. PMID: 20858122.
        View in: PubMed
      40. Grabowski J, Vazquez DE, Costantini T, Cauvi DM, Charles W, Bickler S, Talamini MA, Vega VL, Coimbra R, De Maio A. Tumor necrosis factor expression is ameliorated after exposure to an acidic environment. J Surg Res. 2012 Mar; 173(1):127-34. PMID: 20888586.
        View in: PubMed
      41. Costantini T, Bansal V, Krzyzaniak M, Putnam JG, Peterson CY, Loomis WH, Wolf P, Baird A, Eliceiri BP, Coimbra R. Vagal nerve stimulation protects against burn-induced intestinal injury through activation of enteric glia cells. Am J Physiol Gastrointest Liver Physiol. 2010 Dec; 299(6):G1308-18. PMID: 20705905.
        View in: PubMed
      42. Costantini T, Bansal V, Peterson CY, Loomis WH, Putnam JG, Rankin F, Wolf P, Eliceiri BP, Baird A, Coimbra R. Efferent vagal nerve stimulation attenuates gut barrier injury after burn: modulation of intestinal occludin expression. J Trauma. 2010 Jun; 68(6):1349-54; discussion 1354-6. PMID: 20539179.
        View in: PubMed
      43. Bansal V, Costantini T, Ryu SY, Peterson C, Loomis W, Putnam J, Elicieri B, Baird A, Coimbra R. Stimulating the central nervous system to prevent intestinal dysfunction after traumatic brain injury. J Trauma. 2010 May; 68(5):1059-64. PMID: 20453760.
        View in: PubMed
      44. Peterson CY, Costantini T, Loomis WH, Putnam JG, Wolf P, Bansal V, Eliceiri BP, Baird A, Coimbra R. Toll-like receptor-4 mediates intestinal barrier breakdown after thermal injury. Surg Infect (Larchmt). 2010 Apr; 11(2):137-44. PMID: 20374005.
        View in: PubMed
      45. Costantini T, Deree J, Martins JO, Loomis WH, Bansal V, Coimbra R. Pentoxifylline attenuates leukoreduced stored blood-induced neutrophil activation through inhibition of mitogen-activated protein kinases. Immunopharmacol Immunotoxicol. 2010 Mar; 32(1):74-81. PMID: 19697996.
        View in: PubMed
      46. Costantini T, Deree J, Peterson CY, Putnam JG, Woon T, Loomis WH, Bansal V, Coimbra R. Pentoxifylline modulates p47phox activation and downregulates neutrophil oxidative burst through PKA-dependent and -independent mechanisms. Immunopharmacol Immunotoxicol. 2010 Mar; 32(1):82-91. PMID: 19839729.
        View in: PubMed
      47. Costantini T, Peterson CY, Kroll L, Loomis WH, Putnam JG, Wolf P, Eliceiri BP, Baird A, Bansal V, Coimbra R. Burns, inflammation, and intestinal injury: protective effects of an anti-inflammatory resuscitation strategy. J Trauma. 2009 Dec; 67(6):1162-8. PMID: 20009662.
        View in: PubMed
      48. Costantini T, Fraga G, Fortlage D, Wynn S, Fraga A, Lee J, Doucet J, Bansal V, Coimbra R. Redefining renal dysfunction in trauma: implementation of the Acute Kidney Injury Network staging system. J Trauma. 2009 Aug; 67(2):283-7; discussion 287-8. PMID: 19667880.
        View in: PubMed
      49. Shaterian A, Borboa A, Sawada R, Costantini T, Potenza B, Coimbra R, Baird A, Eliceiri BP. Real-time analysis of the kinetics of angiogenesis and vascular permeability in an animal model of wound healing. Burns. 2009 Sep; 35(6):811-7. PMID: 19423227.
        View in: PubMed
      50. Costantini T, Peterson CY, Kroll L, Loomis WH, Eliceiri BP, Baird A, Bansal V, Coimbra R. Role of p38 MAPK in burn-induced intestinal barrier breakdown. J Surg Res. 2009 Sep; 156(1):64-9. PMID: 19577248.
        View in: PubMed
      51. Costantini T, Loomis WH, Putnam JG, Drusinsky D, Deree J, Choi S, Wolf P, Baird A, Eliceiri B, Bansal V, Coimbra R. Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins. Shock. 2009 Apr; 31(4):416-22. PMID: 18791495.
        View in: PubMed
      52. Costantini T, Loomis WH, Putnam JG, Kroll L, Eliceiri BP, Baird A, Bansal V, Coimbra R. Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase. J Trauma. 2009 Jan; 66(1):17-24; discussion 24-5. PMID: 19131801.
        View in: PubMed
      53. Costantini T, Deree J, Loomis W, Putnam JG, Choi S, Baird A, Eliceiri BP, Bansal V, Coimbra R. Phosphodiesterase inhibition attenuates alterations to the tight junction proteins occludin and ZO-1 in immunostimulated Caco-2 intestinal monolayers. Life Sci. 2009 Jan 2; 84(1-2):18-22. PMID: 18992758.
        View in: PubMed
      54. Costantini T, Acosta JA, Hoyt DB, Ramamoorthy S. Surgical resident and attending physician attitudes toward glucose control in the surgical patient. Am Surg. 2008 Oct; 74(10):993-6. PMID: 18942630.
        View in: PubMed
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