Enfu Hui

Title(s)	Associate Professor, Cell and Developmental Biology
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

Awards and Honors

National Cancer Institute	2019	R37 MERIT Award for ESI
The Pew Charitable Trust	2018	Pew Biomedical Scholar
Searle Scholar Program	2018	Searle Scholar
Leukemia & Lymphoma Society	2011	Postdoctoral Fellowship

Overview

Websites

	Hui Lab at UCSD
	Searle Scholar Profile
	Pew Scholar Profile

In The News

	T Cells Can Activate Themselves to Fight Tumors (05/08/2023)
	Enfu Hui Named 2018 Searle Scholar (04/06/2018)
	Clues Uncovered to Determine Patient's Response to Immunotherapy
	UCSD Biologists discover process that neutralizes tumors against invading cancer cells
	37 Investigators Transforming the Landscape of Biomedical Science
	UC faculty named 2018 Pew biomedical scholars and fellows
	Pew Selects 22 Scientists to Investigate Fundamental Biomedical Questions
	Newly Discovered Process May Lead Cancer Tumors to Neutralize Themselves

Research

Research Activities and Funding

Regulation of PD-L1/PD-1 immune checkpoints by cis-interactions
NIH R37CA239072Mar 1, 2019 - Feb 29, 2024
Role: Principal Investigator

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Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity. Nat Immunol. 2023 Dec; 24(12):2032-2041. Tang Z, Zhong MC, Qian J, Galindo CC, Davidson D, Li J, Zhao Y, Hui E, Veillette A. PMID: 37945822.

View in: PubMed Mentions: 5 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Cis Interactions of Membrane Receptors and Ligands. Annu Rev Cell Dev Biol. 2023 10 16; 39:391-408. Hui E. PMID: 37339682.

View in: PubMed Mentions: Fields:
Bio Biology Cel Cell Biology
Translation:Cells
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity. Immunity. 2023 06 13; 56(6):1187-1203.e12. Zhao Y, Caron C, Chan YY, Lee CK, Xu X, Zhang J, Masubuchi T, Wu C, Bui JD, Hui E. PMID: 37160118; PMCID: PMC10330546.

View in: PubMed Mentions: 17 Fields:
All Allergy and Immunology
Translation:Animals Cells
CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis. J Exp Med. 2023 07 03; 220(7). Xu X, Dennett P, Zhang J, Sherrard A, Zhao Y, Masubuchi T, Bui JD, Chen X, Hui E. PMID: 37042938; PMCID: PMC10103642.

View in: PubMed Mentions: 4 Fields:
All Allergy and Immunology Med Medicine (General)
Translation:Humans
In Situ Assembly of Transmembrane Proteins from Expressed and Synthetic Components in Giant Unilamellar Vesicles. ACS Chem Biol. 2022 05 20; 17(5):1015-1021. Podolsky KA, Masubuchi T, Debelouchina GT, Hui E, Devaraj NK. PMID: 35482050; PMCID: PMC9255206.

View in: PubMed Mentions: Fields:
Bio Biochemistry Bio Biology
Translation:Animals
Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses. Immunity. 2022 03 08; 55(3):512-526.e9. Banta KL, Xu X, Chitre AS, Au-Yeung A, Takahashi C, O'Gorman WE, Wu TD, Mittman S, Cubas R, Comps-Agrar L, Fulzele A, Bennett EJ, Grogan JL, Hui E, Chiang EY, Mellman I. PMID: 35263569; PMCID: PMC9287124.

View in: PubMed Mentions: 94 Fields:
All Allergy and Immunology
Translation:Humans Cells
Enhancing the therapeutic efficacy of programmed death ligand 1 antibody for metastasized liver cancer by overcoming hepatic immunotolerance in mice. Hepatology. 2022 09; 76(3):630-645. Xin B, Yang M, Wu P, Du L, Deng X, Hui E, Feng GS. PMID: 34860431; PMCID: PMC9163212.

View in: PubMed Mentions: 7 Fields:
Gas Gastroenterology
Translation:Animals Cells
Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors. Elife. 2021 11 04; 10. Xu X, Masubuchi T, Cai Q, Zhao Y, Hui E. PMID: 34734802; PMCID: PMC8631942.

View in: PubMed Mentions: 27 Fields:
Bio Biology
Translation:Humans Cells
Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy. Cell. 2020 08 20; 182(4):855-871.e23. Wu W, Zhou Q, Masubuchi T, Shi X, Li H, Xu X, Huang M, Meng L, He X, Zhu H, Gao S, Zhang N, Jing R, Sun J, Wang H, Hui E, Wong CC, Xu C. PMID: 32730808.

View in: PubMed Mentions: 60 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2. J Cell Biol. 2020 06 01; 219(6). Xu X, Hou B, Fulzele A, Masubuchi T, Zhao Y, Wu Z, Hu Y, Jiang Y, Ma Y, Wang H, Bennett EJ, Fu G, Hui E. PMID: 32437509; PMCID: PMC7265324.

View in: PubMed Mentions: 48 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways. Immunity. 2019 12 17; 51(6):1059-1073.e9. Zhao Y, Lee CK, Lin CH, Gassen RB, Xu X, Huang Z, Xiao C, Bonorino C, Lu LF, Bui JD, Hui E. PMID: 31757674; PMCID: PMC6935268.

View in: PubMed Mentions: 163 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
TCR-pMHC bond conformation controls TCR ligand discrimination. Cell Mol Immunol. 2020 03; 17(3):203-217. Sasmal DK, Feng W, Roy S, Leung P, He Y, Cai C, Cao G, Lian H, Qin J, Hui E, Schreiber H, Adams EJ, Huang J. PMID: 31530899; PMCID: PMC7052167.

View in: PubMed Mentions: 18 Fields:
All Allergy and Immunology
Translation:Animals Cells
Understanding T cell signaling using membrane reconstitution. Immunol Rev. 2019 09; 291(1):44-56. Hui E. PMID: 31402497.

View in: PubMed Mentions: 6 Fields:
All Allergy and Immunology Tra Transplantation
Translation:Humans Animals Cells
Immune checkpoint inhibitors. J Cell Biol. 2019 03 04; 218(3):740-741. Hui E. PMID: 30760493; PMCID: PMC6400575.

View in: PubMed Mentions: 25 Fields:
Cel Cell Biology
Translation:Humans
Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells. Cell Rep. 2018 07 10; 24(2):379-390.e6. Zhao Y, Harrison DL, Song Y, Ji J, Huang J, Hui E. PMID: 29996099; PMCID: PMC6093302.

View in: PubMed Mentions: 94 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase. Proc Natl Acad Sci U S A. 2017 10 31; 114(44):E9338-E9345. Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD. PMID: 29042512; PMCID: PMC5676914.

View in: PubMed Mentions: 45 Fields:
Sci Science
Translation:Humans Animals Cells
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017 03 31; 355(6332):1428-1433. Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD. PMID: 28280247; PMCID: PMC6286077.

View in: PubMed Mentions: 754 Fields:
Sci Science
Translation:Humans Animals Cells
Phase separation of signaling molecules promotes T cell receptor signal transduction. Science. 2016 Apr 29; 352(6285):595-9. Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD. PMID: 27056844; PMCID: PMC4892427.

View in: PubMed Mentions: 505 Fields:
Sci Science
Translation:Humans Cells
A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores. J Neurosci. 2015 Apr 08; 35(14):5772-80. Chang CW, Hui E, Bai J, Bruns D, Chapman ER, Jackson MB. PMID: 25855187; PMCID: PMC4388931.

View in: PubMed Mentions: 37 Fields:
Neu Neurology
Translation:Humans Animals Cells
Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. Elife. 2014 Feb 25; 3:e01524. Liu H, Bai H, Hui E, Yang L, Evans CS, Wang Z, Kwon SE, Chapman ER. PMID: 24569478; PMCID: PMC3930910.

View in: PubMed Mentions: 68 Fields:
Bio Biology
Translation:Animals Cells
In vitro membrane reconstitution of the T-cell receptor proximal signaling network. Nat Struct Mol Biol. 2014 Feb; 21(2):133-42. Hui E, Vale RD. PMID: 24463463; PMCID: PMC4062301.

View in: PubMed Mentions: 82 Fields:
Mol Molecular Biology
Translation:Cells
Mechanism and function of synaptotagmin-mediated membrane apposition. Nat Struct Mol Biol. 2011 Jun 05; 18(7):813-21. Hui E, Gaffaney JD, Wang Z, Johnson CP, Evans CS, Chapman ER. PMID: 21642967; PMCID: PMC3130839.

View in: PubMed Mentions: 53 Fields:
Mol Molecular Biology
Translation:Animals Cells
Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells. Mol Biol Cell. 2009 Dec; 20(24):5086-95. Zhang Z, Hui E, Chapman ER, Jackson MB. PMID: 19828732; PMCID: PMC2793286.

View in: PubMed Mentions: 27 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion. Cell. 2009 Aug 21; 138(4):709-21. Hui E, Johnson CP, Yao J, Dunning FM, Chapman ER. PMID: 19703397; PMCID: PMC2758036.

View in: PubMed Mentions: 180 Fields:
Cel Cell Biology
Translation:Animals Cells
Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis. J Biol Chem. 2008 Nov 14; 283(46):31763-75. Gaffaney JD, Dunning FM, Wang Z, Hui E, Chapman ER. PMID: 18784080; PMCID: PMC2581593.

View in: PubMed Mentions: 49 Fields:
Bio Biochemistry
Translation:Animals Cells
Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo. J Neurosci. 2008 Jul 23; 28(30):7458-66. Paddock BE, Striegel AR, Hui E, Chapman ER, Reist NE. PMID: 18650324; PMCID: PMC2949296.

View in: PubMed Mentions: 27 Fields:
Neu Neurology
Translation:Animals Cells
Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+. Nat Struct Mol Biol. 2008 Aug; 15(8):827-35. Chicka MC, Hui E, Liu H, Chapman ER. PMID: 18622390; PMCID: PMC2570314.

View in: PubMed Mentions: 116 Fields:
Mol Molecular Biology
Translation:Animals Cells
Synaptotagmin perturbs the structure of phospholipid bilayers. Biochemistry. 2008 Feb 19; 47(7):2143-52. Shahin V, Datta D, Hui E, Henderson RM, Chapman ER, Edwardson JM. PMID: 18205405; PMCID: PMC3095487.

View in: PubMed Mentions: 12 Fields:
Bio Biochemistry
Translation:Cells
Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I. Biophys J. 2006 Sep 01; 91(5):1767-77. Hui E, Bai J, Chapman ER. PMID: 16782782; PMCID: PMC1544279.

View in: PubMed Mentions: 66 Fields:
Bio Biophysics
Translation:Cells
Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5210-4. Hui E, Bai J, Wang P, Sugimori M, Llinas RR, Chapman ER. PMID: 15793006; PMCID: PMC556003.

View in: PubMed Mentions: 98 Fields:
Sci Science
Translation:Animals Cells