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Enfu Hui

Title(s)Assistant Professor, Cell and Developmental Biology
SchoolAcademic Aff
Address9500 Gilman Drive #0347
La Jolla CA 92093
Phone858-246-0832
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    Collapse Biography 
    Collapse Awards and Honors
    National Cancer Institute2019R37 MERIT Award for ESI
    The Pew Charitable Trust2018Pew Biomedical Scholar
    Searle Scholar Program2018Searle Scholar
    Leukemia & Lymphoma Society2011Postdoctoral Fellowship

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of PD-L1/PD-1 immune checkpoints by cis-interactions
    NIH/NCI R37CA239072Mar 1, 2019 - Feb 29, 2024
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2. J Cell Biol. 2020 Jun 01; 219(6). Xu X, Hou B, Fulzele A, Masubuchi T, Zhao Y, Wu Z, Hu Y, Jiang Y, Ma Y, Wang H, Bennett EJ, Fu G, Hui E. PMID: 32437509.
      View in: PubMed   Mentions:    Fields:    
    2. PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways. Immunity. 2019 12 17; 51(6):1059-1073.e9. Zhao Y, Lee CK, Lin CH, Gassen RB, Xu X, Huang Z, Xiao C, Bonorino C, Lu LF, Bui JD, Hui E. PMID: 31757674.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. TCR-pMHC bond conformation controls TCR ligand discrimination. Cell Mol Immunol. 2020 Mar; 17(3):203-217. Sasmal DK, Feng W, Roy S, Leung P, He Y, Cai C, Cao G, Lian H, Qin J, Hui E, Schreiber H, Adams EJ, Huang J. PMID: 31530899.
      View in: PubMed   Mentions: 1     Fields:    
    4. Understanding T cell signaling using membrane reconstitution. Immunol Rev. 2019 09; 291(1):44-56. Hui E. PMID: 31402497.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Immune checkpoint inhibitors. J Cell Biol. 2019 03 04; 218(3):740-741. Hui E. PMID: 30760493.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells. Cell Rep. 2018 07 10; 24(2):379-390.e6. Zhao Y, Harrison DL, Song Y, Ji J, Huang J, Hui E. PMID: 29996099.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    7. In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase. Proc Natl Acad Sci U S A. 2017 10 31; 114(44):E9338-E9345. Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD. PMID: 29042512.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    8. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017 03 31; 355(6332):1428-1433. Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD. PMID: 28280247.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    9. Phase separation of signaling molecules promotes T cell receptor signal transduction. Science. 2016 Apr 29; 352(6285):595-9. Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD. PMID: 27056844.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    10. A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores. J Neurosci. 2015 Apr 08; 35(14):5772-80. Chang CW, Hui E, Bai J, Bruns D, Chapman ER, Jackson MB. PMID: 25855187.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    11. Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. Elife. 2014 Feb 25; 3:e01524. Liu H, Bai H, Hui E, Yang L, Evans CS, Wang Z, Kwon SE, Chapman ER. PMID: 24569478.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    12. In vitro membrane reconstitution of the T-cell receptor proximal signaling network. Nat Struct Mol Biol. 2014 Feb; 21(2):133-42. Hui E, Vale RD. PMID: 24463463.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    13. Mechanism and function of synaptotagmin-mediated membrane apposition. Nat Struct Mol Biol. 2011 Jun 05; 18(7):813-21. Hui E, Gaffaney JD, Wang Z, Johnson CP, Evans CS, Chapman ER. PMID: 21642967.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    14. Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions. Mol Biol Cell. 2010 Aug 15; 21(16):2821-31. Zhang Z, Hui E, Chapman ER, Jackson MB. PMID: 20573977.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    15. Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells. Mol Biol Cell. 2009 Dec; 20(24):5086-95. Zhang Z, Hui E, Chapman ER, Jackson MB. PMID: 19828732.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    16. Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion. Cell. 2009 Aug 21; 138(4):709-21. Hui E, Johnson CP, Yao J, Dunning FM, Chapman ER. PMID: 19703397.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    17. Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis. J Biol Chem. 2008 Nov 14; 283(46):31763-75. Gaffaney JD, Dunning FM, Wang Z, Hui E, Chapman ER. PMID: 18784080.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    18. Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo. J Neurosci. 2008 Jul 23; 28(30):7458-66. Paddock BE, Striegel AR, Hui E, Chapman ER, Reist NE. PMID: 18650324.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    19. Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+. Nat Struct Mol Biol. 2008 Aug; 15(8):827-35. Chicka MC, Hui E, Liu H, Chapman ER. PMID: 18622390.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    20. Synaptotagmin perturbs the structure of phospholipid bilayers. Biochemistry. 2008 Feb 19; 47(7):2143-52. Shahin V, Datta D, Hui E, Henderson RM, Chapman ER, Edwardson JM. PMID: 18205405.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    21. Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I. Biophys J. 2006 Sep 01; 91(5):1767-77. Hui E, Bai J, Chapman ER. PMID: 16782782.
      View in: PubMed   Mentions: 53     Fields:    Translation:Cells
    22. Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5210-4. Hui E, Bai J, Wang P, Sugimori M, Llinas RR, Chapman ER. PMID: 15793006.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
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