Enfu Hui

Title(s)Assistant Researcher, Cell and Developmental Biology
SchoolAcademic Aff
vCardDownload vCard

    Collapse Biography 
    Collapse Awards and Honors
    National Cancer Institute2019R37 MERIT Award for ESI
    The Pew Charitable Trust2018Pew Biomedical Scholar
    Searle Scholar Program2018Searle Scholar
    Leukemia & Lymphoma Society2011Postdoctoral Fellowship

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Hui E. Understanding T cell signaling using membrane reconstitution. Immunol Rev. 2019 Sep; 291(1):44-56. PMID: 31402497.
      View in: PubMed
    2. Hui E. Immune checkpoint inhibitors. J Cell Biol. 2019 Mar 04; 218(3):740-741. PMID: 30760493.
      View in: PubMed
    3. Zhao Y, Harrison DL, Song Y, Ji J, Huang J, Hui E. Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells. Cell Rep. 2018 Jul 10; 24(2):379-390.e6. PMID: 29996099.
      View in: PubMed
    4. Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD. In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase. Proc Natl Acad Sci U S A. 2017 10 31; 114(44):E9338-E9345. PMID: 29042512.
      View in: PubMed
    5. Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017 03 31; 355(6332):1428-1433. PMID: 28280247.
      View in: PubMed
    6. Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD. Phase separation of signaling molecules promotes T cell receptor signal transduction. Science. 2016 Apr 29; 352(6285):595-9. PMID: 27056844; PMCID: PMC4892427 [Available on 10/29/16].
    7. Chang CW, Hui E, Bai J, Bruns D, Chapman ER, Jackson MB. A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores. J Neurosci. 2015 Apr 08; 35(14):5772-80. PMID: 25855187.
      View in: PubMed
    8. Liu H, Bai H, Hui E, Yang L, Evans CS, Wang Z, Kwon SE, Chapman ER. Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. Elife. 2014 Feb 25; 3:e01524. PMID: 24569478; PMCID: PMC3930910.
    9. Hui E, Vale RD. In vitro membrane reconstitution of the T-cell receptor proximal signaling network. Nat Struct Mol Biol. 2014 Feb; 21(2):133-42. PMID: 24463463; PMCID: PMC4062301.
    10. Hui E, Gaffaney JD, Wang Z, Johnson CP, Evans CS, Chapman ER. Mechanism and function of synaptotagmin-mediated membrane apposition. Nat Struct Mol Biol. 2011 Jun 05; 18(7):813-21. PMID: 21642967; PMCID: PMC3130839.
    11. Zhang Z, Hui E, Chapman ER, Jackson MB. Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions. Mol Biol Cell. 2010 Aug 15; 21(16):2821-31. PMID: 20573977; PMCID: PMC2921110.
    12. Zhang Z, Hui E, Chapman ER, Jackson MB. Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells. Mol Biol Cell. 2009 Dec; 20(24):5086-95. PMID: 19828732.
      View in: PubMed
    13. Hui E, Johnson CP, Yao J, Dunning FM, Chapman ER. Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion. Cell. 2009 Aug 21; 138(4):709-21. PMID: 19703397; PMCID: PMC2758036.
    14. Gaffaney JD, Dunning FM, Wang Z, Hui E, Chapman ER. Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis. J Biol Chem. 2008 Nov 14; 283(46):31763-75. PMID: 18784080; PMCID: PMC2581593.
    15. Paddock BE, Striegel AR, Hui E, Chapman ER, Reist NE. Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo. J Neurosci. 2008 Jul 23; 28(30):7458-66. PMID: 18650324; PMCID: PMC2949296.
    16. Chicka MC, Hui E, Liu H, Chapman ER. Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+. Nat Struct Mol Biol. 2008 Aug; 15(8):827-35. PMID: 18622390; PMCID: PMC2570314.
    17. Shahin V, Datta D, Hui E, Henderson RM, Chapman ER, Edwardson JM. Synaptotagmin perturbs the structure of phospholipid bilayers. Biochemistry. 2008 Feb 19; 47(7):2143-52. PMID: 18205405; PMCID: PMC3095487.
    18. Hui E, Bai J, Chapman ER. Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I. Biophys J. 2006 Sep 01; 91(5):1767-77. PMID: 16782782; PMCID: PMC1544279.
    19. Hui E, Bai J, Wang P, Sugimori M, Llinas RR, Chapman ER. Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5210-4. PMID: 15793006; PMCID: PMC556003.