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Enfu Hui

Title(s)Assistant Professor, Cell and Developmental Biology
SchoolAcademic Aff
Phone858-246-0832
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    Collapse Biography 
    Collapse Awards and Honors
    National Cancer Institute2019R37 MERIT Award for ESI
    The Pew Charitable Trust2018Pew Biomedical Scholar
    Searle Scholar Program2018Searle Scholar
    Leukemia & Lymphoma Society2011Postdoctoral Fellowship

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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hui E. Immune checkpoint inhibitors. J Cell Biol. 2019 Feb 13. PMID: 30760493.
      View in: PubMed
    2. Zhao Y, Harrison DL, Song Y, Ji J, Huang J, Hui E. Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells. Cell Rep. 2018 Jul 10; 24(2):379-390.e6. PMID: 29996099.
      View in: PubMed
    3. Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD. In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase. Proc Natl Acad Sci U S A. 2017 10 31; 114(44):E9338-E9345. PMID: 29042512.
      View in: PubMed
    4. Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017 03 31; 355(6332):1428-1433. PMID: 28280247.
      View in: PubMed
    5. Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD. Phase separation of signaling molecules promotes T cell receptor signal transduction. Science. 2016 Apr 29; 352(6285):595-9. PMID: 27056844; PMCID: PMC4892427 [Available on 10/29/16].
    6. Chang CW, Hui E, Bai J, Bruns D, Chapman ER, Jackson MB. A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores. J Neurosci. 2015 Apr 08; 35(14):5772-80. PMID: 25855187; PMCID: PMC4388931.
    7. Liu H, Bai H, Hui E, Yang L, Evans CS, Wang Z, Kwon SE, Chapman ER. Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. Elife. 2014 Feb 25; 3:e01524. PMID: 24569478; PMCID: PMC3930910.
    8. Hui E, Vale RD. In vitro membrane reconstitution of the T-cell receptor proximal signaling network. Nat Struct Mol Biol. 2014 Feb; 21(2):133-42. PMID: 24463463; PMCID: PMC4062301.
    9. Hui E, Gaffaney JD, Wang Z, Johnson CP, Evans CS, Chapman ER. Mechanism and function of synaptotagmin-mediated membrane apposition. Nat Struct Mol Biol. 2011 Jun 05; 18(7):813-21. PMID: 21642967; PMCID: PMC3130839.
    10. Zhang Z, Hui E, Chapman ER, Jackson MB. Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions. Mol Biol Cell. 2010 Aug 15; 21(16):2821-31. PMID: 20573977; PMCID: PMC2921110.
    11. Zhang Z, Hui E, Chapman ER, Jackson MB. Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells. Mol Biol Cell. 2009 Dec; 20(24):5086-95. PMID: 19828732.
      View in: PubMed
    12. Hui E, Johnson CP, Yao J, Dunning FM, Chapman ER. Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion. Cell. 2009 Aug 21; 138(4):709-21. PMID: 19703397; PMCID: PMC2758036.
    13. Gaffaney JD, Dunning FM, Wang Z, Hui E, Chapman ER. Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis. J Biol Chem. 2008 Nov 14; 283(46):31763-75. PMID: 18784080; PMCID: PMC2581593.
    14. Paddock BE, Striegel AR, Hui E, Chapman ER, Reist NE. Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo. J Neurosci. 2008 Jul 23; 28(30):7458-66. PMID: 18650324; PMCID: PMC2949296.
    15. Chicka MC, Hui E, Liu H, Chapman ER. Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+. Nat Struct Mol Biol. 2008 Aug; 15(8):827-35. PMID: 18622390; PMCID: PMC2570314.
    16. Shahin V, Datta D, Hui E, Henderson RM, Chapman ER, Edwardson JM. Synaptotagmin perturbs the structure of phospholipid bilayers. Biochemistry. 2008 Feb 19; 47(7):2143-52. PMID: 18205405; PMCID: PMC3095487.
    17. Hui E, Bai J, Chapman ER. Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I. Biophys J. 2006 Sep 01; 91(5):1767-77. PMID: 16782782; PMCID: PMC1544279.
    18. Hui E, Bai J, Wang P, Sugimori M, Llinas RR, Chapman ER. Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5210-4. PMID: 15793006; PMCID: PMC556003.