Fotios Asimakopoulos
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Title(s) | Associate Professor In Residence, Medicine |
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School | Health Sciences |
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Address | 9500 Gilman Drive #0960 La Jolla CA 92093
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vCard | Download vCard |
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Biography University of Cambridge, Cambridge UK | MD PhD | 01/1997 | Medicine, Hematology | Hebrew University of Jerusalem, Jerusalem Israel | Golda Meir Fellow | 06/1999 | Hematology | BWH, Harvard Medical School, Boston MA | Residency | 06/2001 | Internal Medicine | Memorial Sloan-Kettering Cancer Center, New York, NY | Fellowship | 06/2009 | Medical Oncology | ABIM Board Certification | | | Medical Oncology |
Overview Our lab focuses on multiple myeloma, the second most common blood cancer. Myeloma is a growing problem in the ageing population and despite great advances in therapy in the last 15-20 years, it remains incurable for the vast majority of patients. Despite effective modern and more traditional treatment approaches, almost all patients will see their disease come back at some point in their course. For many of our patients myeloma can become a “chronic condition”: unfortunately however, the myeloma cancer cells tend to evolve more aggressive and drug-resistant with time, and when they come back, they often come back with vengeance. We are working towards the goal of making myeloma a problem that most patients can overcome and conquer for good.
Research ORNG Applications Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Expression of NrasQ61R and MYC transgene in germinal center B cells induces a highly malignant multiple myeloma in mice. Blood. 2020 Jul 08.
Wen Z, Rajagopalan A, Flietner E, Yun G, Chesi M, Furumo Q, Burns RT, Papadas A, Ranheim EA, Pagenkopf AC, Morrow ZT, Finn R, Zhou Y, Li S, You X, Jensen JL, Yu M, Cicala A, Menting J, Mitsiades CS, Callander NS, Bergsagel PL, Wang D, Asimakopoulos F, Zhang J. PMID: 32640012.
View in: PubMed Mentions: 1 Fields:
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Versican and Versican-matrikines in Cancer Progression, Inflammation, and Immunity. J Histochem Cytochem. 2020 Jul 06; 22155420937098.
Papadas A, Arauz G, Cicala A, Wiesner J, Asimakopoulos F. PMID: 32623942.
View in: PubMed Mentions: Fields:
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Versican in the Tumor Microenvironment. Adv Exp Med Biol. 2020; 1272:55-72.
Papadas A, Asimakopoulos F. PMID: 32845502.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Versican proteolysis predicts immune effector infiltration and post-transplant survival in myeloma. Leuk Lymphoma. 2019 10; 60(10):2558-2562.
Dhakal B, Pagenkopf A, Mushtaq MU, Cunningham AM, Flietner E, Morrow Z, Papadas A, Hope C, Leith C, Hematti P, Hari P, Callander NS, Asimakopoulos F. PMID: 30845856.
View in: PubMed Mentions: 3 Fields: Translation: HumansCells
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TIGIT checkpoint inhibition for myeloma. Blood. 2018 10 18; 132(16):1629-1630.
Asimakopoulos F. PMID: 30337318.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Tumor matrix remodeling and novel immunotherapies: the promise of matrix-derived immune biomarkers. J Immunother Cancer. 2018 07 03; 6(1):65.
Mushtaq MU, Papadas A, Pagenkopf A, Flietner E, Morrow Z, Chaudhary SG, Asimakopoulos F. PMID: 29970158.
View in: PubMed Mentions: 18 Fields: Translation: HumansCells
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Autologous Transplantation for Newly Diagnosed Multiple Myeloma in the Era of Novel Agent Induction: A Systematic Review and Meta-analysis. JAMA Oncol. 2018 Mar 01; 4(3):343-350.
Dhakal B, Szabo A, Chhabra S, Hamadani M, D'Souza A, Usmani SZ, Sieracki R, Gyawali B, Jackson JL, Asimakopoulos F, Hari PN. PMID: 29302684.
View in: PubMed Mentions: 10 Fields: Translation: Humans
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Mechanisms of Resistance in Multiple Myeloma. Handb Exp Pharmacol. 2018; 249:251-288.
Papadas A, Asimakopoulos F. PMID: 28315070.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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Hyaluronan and proteoglycan link protein 1 (HAPLN1) activates bortezomib-resistant NF-κB activity and increases drug resistance in multiple myeloma. J Biol Chem. 2018 02 16; 293(7):2452-2465.
Huynh M, Pak C, Markovina S, Callander NS, Chng KS, Wuerzberger-Davis SM, Bakshi DD, Kink JA, Hematti P, Hope C, Asimakopoulos F, Rui L, Miyamoto S. PMID: 29279332.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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Extracellular matrix and the myeloid-in-myeloma compartment: balancing tolerogenic and immunogenic inflammation in the myeloma niche. J Leukoc Biol. 2017 08; 102(2):265-275.
Asimakopoulos F, Hope C, Johnson MG, Pagenkopf A, Gromek K, Nagel B. PMID: 28254840.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Immunoregulatory roles of versican proteolysis in the myeloma microenvironment. Blood. 2016 08 04; 128(5):680-5.
Hope C, Foulcer S, Jagodinsky J, Chen SX, Jensen JL, Patel S, Leith C, Maroulakou I, Callander N, Miyamoto S, Hematti P, Apte SS, Asimakopoulos F. PMID: 27259980.
View in: PubMed Mentions: 36 Fields: Translation: HumansAnimalsCells
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Deploying myeloid cells against myeloma. Oncoimmunology. 2016 Mar; 5(3):e1090076.
Jensen JL, Hope C, Asimakopoulos F. PMID: 27141348.
View in: PubMed Mentions:
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Single-molecule analysis reveals widespread structural variation in multiple myeloma. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7689-94.
Gupta A, Place M, Goldstein S, Sarkar D, Zhou S, Potamousis K, Kim J, Flanagan C, Li Y, Newton MA, Callander NS, Hematti P, Bresnick EH, Ma J, Asimakopoulos F, Schwartz DC. PMID: 26056298.
View in: PubMed Mentions: 14 Fields: Translation: Humans
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MicroC(3): an ex vivo microfluidic cis-coculture assay to test chemosensitivity and resistance of patient multiple myeloma cells. Integr Biol (Camb). 2015 Jun; 7(6):643-54.
Pak C, Callander NS, Young EW, Titz B, Kim K, Saha S, Chng K, Asimakopoulos F, Beebe DJ, Miyamoto S. PMID: 25998180.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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Tumoricidal Effects of Macrophage-Activating Immunotherapy in a Murine Model of Relapsed/Refractory Multiple Myeloma. Cancer Immunol Res. 2015 Aug; 3(8):881-90.
Jensen JL, Rakhmilevich A, Heninger E, Broman AT, Hope C, Phan F, Miyamoto S, Maroulakou I, Callander N, Hematti P, Chesi M, Bergsagel PL, Sondel P, Asimakopoulos F. PMID: 25941352.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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Acetyl-L-carnitine (ALCAR) for the prevention of chemotherapy-induced peripheral neuropathy in patients with relapsed or refractory multiple myeloma treated with bortezomib, doxorubicin and low-dose dexamethasone: a study from the Wisconsin Oncology Network. Cancer Chemother Pharmacol. 2014 Oct; 74(4):875-82.
Callander N, Markovina S, Eickhoff J, Hutson P, Campbell T, Hematti P, Go R, Hegeman R, Longo W, Williams E, Asimakopoulos F, Miyamoto S. PMID: 25168296.
View in: PubMed Mentions: 12 Fields: Translation: HumansCTClinical Trials
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TPL2 kinase regulates the inflammatory milieu of the myeloma niche. Blood. 2014 May 22; 123(21):3305-15.
Hope C, Ollar SJ, Heninger E, Hebron E, Jensen JL, Kim J, Maroulakou I, Miyamoto S, Leith C, Yang DT, Callander N, Hematti P, Chesi M, Bergsagel PL, Asimakopoulos F. PMID: 24723682.
View in: PubMed Mentions: 27 Fields: Translation: HumansAnimalsCells
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Macrophages in multiple myeloma: emerging concepts and therapeutic implications. Leuk Lymphoma. 2013 Oct; 54(10):2112-21.
Asimakopoulos F, Kim J, Denu RA, Hope C, Jensen JL, Ollar SJ, Hebron E, Flanagan C, Callander N, Hematti P. PMID: 23432691.
View in: PubMed Mentions: 21 Fields: Translation: HumansAnimalsCells
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MAP3K8 kinase regulates myeloma growth by cell-autonomous and non-autonomous mechanisms involving myeloma-associated monocytes/macrophages. Br J Haematol. 2013 Mar; 160(6):779-84.
Hebron E, Hope C, Kim J, Jensen JL, Flanagan C, Bhatia N, Maroulakou I, Mitsiades C, Miyamoto S, Callander N, Hematti P, Asimakopoulos F. PMID: 23252623.
View in: PubMed Mentions: 4 Fields: Translation: HumansCells
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Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells. Br J Haematol. 2012 Aug; 158(3):336-46.
Kim J, Denu RA, Dollar BA, Escalante LE, Kuether JP, Callander NS, Asimakopoulos F, Hematti P. PMID: 22583117.
View in: PubMed Mentions: 43 Fields: Translation: HumansCells
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Year | Publications |
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2012 | 2 | 2013 | 1 | 2014 | 2 | 2015 | 4 | 2016 | 1 | 2017 | 2 | 2018 | 4 | 2019 | 1 | 2020 | 3 |
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This graph shows the number and percent of publications by field.
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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