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Flossie Wong-Staal

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #9111E
La Jolla CA 92093
Phone858-552-8585
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    Collapse Research 
    Collapse Research Activities and Funding
    LENTIVIRAL VECTORS FOR HIV GENE THERAPY
    NIH/NIAID P01AI045992Aug 15, 1999 - Jul 31, 2004
    Role: Co-Principal Investigator
    CONFERENCE ON AIDS PATHOGENESIS
    NIH/NIAID R13AI043951Jan 1, 1999 - Dec 31, 1999
    Role: Principal Investigator
    RIBOZYME GENE THERAPY FOR CD4 AND CD34 CELLS
    NIH/NIDDK R01DK054675Sep 30, 1998 - Jul 31, 2003
    Role: Principal Investigator
    CELLULAR FACTORS INVOLVED IN NUCLEAR EXPORT OF VIRAL RNA
    NIH/NIGMS R01GM056089Jan 1, 1998 - Dec 31, 2001
    Role: Principal Investigator
    FACS VANTAGE CELL SORTER
    NIH/NCRR S10RR011852Feb 1, 1997 - Jun 30, 1998
    Role: Principal Investigator
    TRANSGENIC MICE MODEL FOR RIBOZYME EXPRESSION AND ACT
    NIH/FIC R03TW000678Apr 1, 1996 - Nov 30, 1999
    Role: Principal Investigator
    DEVELOPMENT OF GENE DELIVERY VECTOR
    NIH/NIAID U19AI036612Sep 1, 1994 - Feb 28, 2001
    Role: Principal Investigator
    RIBOZYME GENE THERAPY FOR CD4 AND CD34 CELLS
    NIH/NIDDK R01DK049618Aug 1, 1994 - Sep 30, 1998
    Role: Principal Investigator
    Center for AIDS Research
    NIH/NIAID P30AI036214Apr 1, 1994 - Mar 31, 2023
    Role: Co-Principal Investigator
    REV/REX TRANSACTIVATION PATHWAY OF HIV/HTLV
    NIH/NIAID R01AI031378Jul 1, 1991 - May 31, 1996
    Role: Principal Investigator
    HIV TAT PROTEIN AND KAPOSI'S SARCOMA PATHOGENESIS
    NIH/NCI R01CA052412Feb 1, 1991 - Jan 31, 1994
    Role: Principal Investigator
    IN VIVO AND IN VITRO PARAMETERS OF HIV-2 PATHOGENICITY
    NIH/NIAID R01AI029889Jul 1, 1990 - Jun 30, 1995
    Role: Principal Investigator
    STRATEGIES FOR HIV VACCINE DEVELOPMENT
    NIH/NIAID U01AI030238Jun 15, 1990 - Nov 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mittapalli GK, Zhao F, Jackson A, Gao H, Lee H, Chow S, Kaur MP, Nguyen N, Zamboni R, McKelvy J, Wong-Staal F, Macdonald JE. Discovery of ITX 4520: a highly potent orally bioavailable hepatitis C virus entry inhibitor. Bioorg Med Chem Lett. 2012 Aug 01; 22(15):4955-61. PMID: 22784640.
      View in: PubMed
    2. Mittapalli GK, Jackson A, Zhao F, Lee H, Chow S, McKelvy J, Wong-Staal F, Macdonald JE. Discovery of highly potent small molecule Hepatitis C Virus entry inhibitors. Bioorg Med Chem Lett. 2011 Nov 15; 21(22):6852-5. PMID: 21978675.
      View in: PubMed
    3. Syder AJ, Lee H, Zeisel MB, Grove J, Soulier E, Macdonald J, Chow S, Chang J, Baumert TF, McKeating JA, McKelvy J, Wong-Staal F. Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors. J Hepatol. 2011 Jan; 54(1):48-55. PMID: 20932595.
      View in: PubMed
    4. Fletcher NF, Yang JP, Farquhar MJ, Hu K, Davis C, He Q, Dowd K, Ray SC, Krieger SE, Neyts J, Baumert TF, Balfe P, McKeating JA, Wong-Staal F. Hepatitis C virus infection of neuroepithelioma cell lines. Gastroenterology. 2010 Oct; 139(4):1365-74. PMID: 20538002.
      View in: PubMed
    5. Zhou D, Zhang J, Wang C, Bliesath JR, He Q, Yu D, Li-He Z, Wong-Staal F. A method for detecting and preventing negative RNA interference in preparation of lentiviral vectors for siRNA delivery. RNA. 2009 Apr; 15(4):732-40. PMID: 19244361; PMCID: PMC2661825.
    6. Yang JP, Zhou D, Wong-Staal F. Screening of small-molecule compounds as inhibitors of HCV entry. Methods Mol Biol. 2009; 510:295-304. PMID: 19009270.
      View in: PubMed
    7. Yu DH, Macdonald J, Liu G, Lee AS, Ly M, Davis T, Ke N, Zhou D, Wong-Staal F, Li QX. Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy. PLoS One. 2008; 3(12):e3951. PMID: 19079611; PMCID: PMC2597738.
    8. He QS, Tang H, Zhang J, Truong K, Wong-Staal F, Zhou D. Comparisons of RNAi approaches for validation of human RNA helicase A as an essential factor in hepatitis C virus replication. J Virol Methods. 2008 Dec; 154(1-2):216-9. PMID: 18782589.
      View in: PubMed
    9. Li QX, Liu G, Wong-Staal F. Oncolytic virotherapy as a personalized cancer vaccine. Int J Cancer. 2008 Aug 01; 123(3):493-9. PMID: 18500742.
      View in: PubMed
    10. Falkenstein IA, Cheng L, Wong-Staal F, Tammewar AM, Barron EC, Silva GA, Li QX, Yu D, Hysell M, Liu G, Ke N, Macdonald JE, Freeman WR. Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186. Curr Eye Res. 2008 Jul; 33(7):599-609. PMID: 18600493; PMCID: PMC2664073.
    11. Zhou D, Wang C, Zhang J, Bliesath J, He QS, Ke N, Yu D, Li Q, Zhang LH, Wong-Staal F. Generation of shRNA pool library: a revision of the biological technique from the viewpoint of chemistry. Chembiochem. 2008 Jun 16; 9(9):1365-7. PMID: 18435449.
      View in: PubMed
    12. Ke N, Ma H, Diedrich G, Chionis J, Liu G, Yu DH, Wong-Staal F, Li QX. Biochemical characterization of genetic mutations of GPR56 in patients with bilateral frontoparietal polymicrogyria (BFPP). Biochem Biophys Res Commun. 2008 Feb 08; 366(2):314-20. PMID: 18042463.
      View in: PubMed
    13. Liu G, Grifman M, Macdonald J, Moller P, Wong-Staal F, Li QX. Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase. J Endocrinol. 2007 Sep; 194(3):569-78. PMID: 17761896.
      View in: PubMed
    14. Zhang J, Wang C, Ke N, Bliesath J, Chionis J, He QS, Li QX, Chatterton JE, Wong-Staal F, Zhou D. A more efficient RNAi inducible system for tight regulation of gene expression in mammalian cells and xenograft animals. RNA. 2007 Aug; 13(8):1375-83. PMID: 17616554; PMCID: PMC1924899.
    15. Ke N, Sundaram R, Liu G, Chionis J, Fan W, Rogers C, Awad T, Grifman M, Yu D, Wong-Staal F, Li QX. Orphan G protein-coupled receptor GPR56 plays a role in cell transformation and tumorigenesis involving the cell adhesion pathway. Mol Cancer Ther. 2007 Jun; 6(6):1840-50. PMID: 17575113.
      View in: PubMed
    16. Li QX, Tan P, Ke N, Wong-Staal F. Ribozyme technology for cancer gene target identification and validation. Adv Cancer Res. 2007; 96:103-43. PMID: 17161678.
      View in: PubMed
    17. Yu DH, Macdonald J, Josephs S, Liu Q, Nguy V, Tor Y, Wong-Staal F, Li QX. MDDD, a 4,9-diazapyrenium derivative, is selectively toxic to glioma cells by inducing growth arrest at G0/G1 independently of p53. Invest New Drugs. 2006 Nov; 24(6):489-98. PMID: 16633716.
      View in: PubMed
    18. Ke N, Zhou D, Chatterton JE, Liu G, Chionis J, Zhang J, Tsugawa L, Lynn R, Yu D, Meyhack B, Wong-Staal F, Li QX. A new inducible RNAi xenograft model for assessing the staged tumor response to mTOR silencing. Exp Cell Res. 2006 Sep 10; 312(15):2726-34. PMID: 16765945.
      View in: PubMed
    19. Yang JP, Fan W, Rogers C, Chatterton JE, Bliesath J, Liu G, Ke N, Wang CY, Rhoades K, Wong-Staal F, Li QX. A novel RNAi library based on partially randomized consensus sequences of nuclear receptors: identifying the receptors involved in amyloid beta degradation. Genomics. 2006 Sep; 88(3):282-92. PMID: 16631344.
      View in: PubMed
    20. Kayikcioglu OR, Falkenstein I, Cheng L, Kozak I, La Bree L, Azen SP, Wong-Staal F, Paoni NF, Freeman WR. Therapy with ribozyme to the proliferating cell nuclear antigen-ribozyme and 5-fluorouracil of experimental choroidal neovascularization in rats. J Ocul Pharmacol Ther. 2006 Feb; 22(1):1-9. PMID: 16503769.
      View in: PubMed
    21. Yu DH, Fan W, Liu G, Nguy V, Chatterton JE, Long S, Ke N, Meyhack B, Bruengger A, Brachat A, Wong-Staal F, Li QX. PHTS, a novel putative tumor suppressor, is involved in the transformation reversion of HeLaHF cells independently of the p53 pathway. Exp Cell Res. 2006 Apr 01; 312(6):865-76. PMID: 16413018.
      View in: PubMed
    22. Liu G, Wong-Staal F, Li QX. Recent development of RNAi in drug target discovery and validation. Drug Discov Today Technol. 2006; 3(3):293-300. PMID: 24980531.
      View in: PubMed
    23. Yu DH, Chatterton JE, Bliesath JR, Sundaram R, Ke N, Nguy V, Meyhack B, Wong-Staal F, Li QX. A 96-well surrogate survival assay coupled with a special short interfering RNA vector for assessing cancer gene targets with enhanced signal/noise ratio and its utility in HTS for cancer therapeutic targets. Assay Drug Dev Technol. 2005 Aug; 3(4):401-11. PMID: 16180995.
      View in: PubMed
    24. Ke N, Claassen G, Yu DH, Albers A, Fan W, Tan P, Grifman M, Hu X, Defife K, Nguy V, Meyhack B, Brachat A, Wong-Staal F, Li QX. Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis. Cancer Res. 2004 Nov 15; 64(22):8208-12. PMID: 15548686.
      View in: PubMed
    25. Tetsuka T, Uranishi H, Sanda T, Asamitsu K, Yang JP, Wong-Staal F, Okamoto T. RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator. Eur J Biochem. 2004 Sep; 271(18):3741-51. PMID: 15355351.
      View in: PubMed
    26. Morris KV, Gilbert J, Wong-Staal F, Gasmi M, Looney DJ. Transduction of cell lines and primary cells by FIV-packaged HIV vectors. Mol Ther. 2004 Jul; 10(1):181-90. PMID: 15272479.
      View in: PubMed
    27. Kan-Mitchell J, Bisikirska B, Wong-Staal F, Schaubert KL, Bajcz M, Bereta M. The HIV-1 HLA-A2-SLYNTVATL is a help-independent CTL epitope. J Immunol. 2004 May 01; 172(9):5249-61. PMID: 15100263.
      View in: PubMed
    28. Ke N, Albers A, Claassen G, Yu DH, Chatterton JE, Hu X, Meyhack B, Wong-Staal F, Li QX. One-week 96-well soft agar growth assay for cancer target validation. Biotechniques. 2004 May; 36(5):826-8, 830, 832-3. PMID: 15152603.
      View in: PubMed
    29. Smith WA, Schurter BT, Wong-Staal F, David M. Arginine methylation of RNA helicase a determines its subcellular localization. J Biol Chem. 2004 May 28; 279(22):22795-8. PMID: 15084609.
      View in: PubMed
    30. Yang JP, Reddy TR, Truong KT, Suhasini M, Wong-Staal F. Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K. Oncogene. 2002 Oct 17; 21(47):7187-94. PMID: 12370808.
      View in: PubMed
    31. Cheng L, Chaidhawangul S, Wong-Staal F, Gilbert J, Poeschla E, Toyoguchi M, El-Bradey M, Bergeron-Lynn G, Soules KA, Freeman WR. Human immunodeficiency virus type 2 (HIV-2) vector-mediated in vivo gene transfer into adult rabbit retina. Curr Eye Res. 2002 Mar; 24(3):196-201. PMID: 12221527.
      View in: PubMed
    32. Reddy TR, Suhasini M, Xu W, Yeh LY, Yang JP, Wu J, Artzt K, Wong-Staal F. A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication. J Biol Chem. 2002 Feb 22; 277(8):5778-84. PMID: 11741900.
      View in: PubMed
    33. Cort├ęs MJ, Wong-Staal F, Lama J. Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells. J Biol Chem. 2002 Jan 18; 277(3):1770-9. PMID: 11704677.
      View in: PubMed
    34. Li X, Mukai T, Young D, Frankel S, Law P, Wong-Staal F. Transduction of CD34+ cells by a vesicular stomach virus protein G (VSV-G) pseudotyped HIV-1 vector. Stable gene expression in progeny cells, including dendritic cells. J Hum Virol. 1998 Jul-Aug; 1(5):346-52. PMID: 10195262.
      View in: PubMed