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Scott Thomson

TitleProfessor In Residence
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #9151
La Jolla CA 92093
Phone858-552-7528
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    Collapse Research 
    Collapse Research Activities and Funding
    Glomerular and Tubular Function in the Diabetic Kidney
    NIH/NIDDK R01DK112042Jul 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Homeostasis and Tubuloglomerular Feedback
    VA I01BX000180Apr 1, 2009 - Dec 31, 2017
    Role: Principal Investigator
    Glomerular and Tubular Function in the Diabetic Kidney
    NIH/NIDDK R01DK056248Sep 15, 1999 - Jun 30, 2015
    Role: Principal Investigator
    Nephrology Training Grant
    NIH/NIDDK T32DK007671Sep 30, 1992 - Jun 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Thomson S, Vallon V. Renal Effects of Incretin-Based Diabetes Therapies: Pre-clinical Predictions and Clinical Trial Outcomes. Curr Diab Rep. 2018 Apr 13; 18(5):28. PMID: 29654381.
      View in: PubMed
    2. Vallon V, Thomson S. Diabetes mellitus: Cardiovascular and renal benefits of SGLT2 inhibition: insights from CANVAS. Nat Rev Nephrol. 2017 Sep; 13(9):517-518. PMID: 28781373.
      View in: PubMed
    3. Thomson S, Kashkouli A, Liu ZZ, Singh P. Renal hemodynamic effects of glucagon-like peptide-1 agonist are mediated by nitric oxide but not prostaglandin. Am J Physiol Renal Physiol. 2017 Oct 01; 313(4):F854-F858. PMID: 28724607.
      View in: PubMed
    4. Vallon V, Thomson S. Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition. Diabetologia. 2017 02; 60(2):215-225. PMID: 27878313.
      View in: PubMed
    5. Singh P, Thomson S. Salt sensitivity of tubuloglomerular feedback in the early remnant kidney. Am J Physiol Renal Physiol. 2014 Jan; 306(2):F172-80. PMID: 24259514; PMCID: PMC3920016.
    6. Vallon V, Gerasimova M, Rose MA, Masuda T, Satriano J, Mayoux E, Koepsell H, Thomson S, Rieg T. SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice. Am J Physiol Renal Physiol. 2014 Jan; 306(2):F194-204. PMID: 24226524; PMCID: PMC3920018.
    7. Rieg T, Masuda T, Gerasimova M, Mayoux E, Platt K, Powell DR, Thomson S, Koepsell H, Vallon V. Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia. Am J Physiol Renal Physiol. 2014 Jan; 306(2):F188-93. PMID: 24226519; PMCID: PMC3920019.
    8. Vallon V, Rose M, Gerasimova M, Satriano J, Platt KA, Koepsell H, Cunard R, Sharma K, Thomson S, Rieg T. Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol. 2013 Jan 15; 304(2):F156-67. PMID: 23152292.
      View in: PubMed
    9. Thomson S, Kashkouli A, Singh P. Glucagon-like peptide-1 receptor stimulation increases GFR and suppresses proximal reabsorption in the rat. Am J Physiol Renal Physiol. 2013 Jan 15; 304(2):F137-44. PMID: 23019232; PMCID: PMC3543628.
    10. Bell HJ, Syed NI. Control of breathing in invertebrate model systems. Compr Physiol. 2012 Jul; 2(3):1745-66. PMID: 23723022.
      View in: PubMed
    11. Thomson S, Blantz RC. Biophysics of glomerular filtration. Compr Physiol. 2012 Jul; 2(3):1671-99. PMID: 23723020.
      View in: PubMed
    12. Blantz RC, Singh P, Deng A, Thomson S, Vallon V. Acute saline expansion increases nephron filtration and distal flow rate but maintains tubuloglomerular feedback responsiveness: role of adenosine A(1) receptors. Am J Physiol Renal Physiol. 2012 Aug 01; 303(3):F405-11. PMID: 22622464; PMCID: PMC3433865.
    13. Teerlink JR, Iragui VJ, Mohr JP, Carson PE, Hauptman PJ, Lovett DH, Miller AB, PiƱa IL, Thomson S, Varosy PD, Zile MR, Cleland JG, Givertz MM, Metra M, Ponikowski P, Voors AA, Davison BA, Cotter G, Wolko D, Delucca P, Salerno CM, Mansoor GA, Dittrich H, O'Connor CM, Massie BM. The safety of an adenosine A(1)-receptor antagonist, rolofylline, in patients with acute heart failure and renal impairment: findings from PROTECT. Drug Saf. 2012 Mar 01; 35(3):233-44. PMID: 22339573.
      View in: PubMed
    14. Singh P, Blantz RC, Rosenberger C, Gabbai FB, Schoeb TR, Thomson S. Aberrant tubuloglomerular feedback and HIF-1a confer resistance to ischemia after subtotal nephrectomy. J Am Soc Nephrol. 2012 Mar; 23(3):483-93. PMID: 22266667; PMCID: PMC3294306.
    15. Vallon V, Thomson S. Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney. Annu Rev Physiol. 2012; 74:351-75. PMID: 22335797; PMCID: PMC3807782.
    16. Thomson S, Rieg T, Miracle C, Mansoury H, Whaley J, Vallon V, Singh P. Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat. Am J Physiol Regul Integr Comp Physiol. 2012 Jan 01; 302(1):R75-83. PMID: 21940401; PMCID: PMC3349378.
    17. Vallon V, Thomson S. Anomalous role for dietary salt in diabetes mellitus? Nat Rev Endocrinol. 2011 May 31; 7(7):377-8. PMID: 21629234; PMCID: PMC3335262.
    18. Thomson S, Blantz RC. A new role for charge of the glomerular capillary membrane. J Am Soc Nephrol. 2010 Dec; 21(12):2011-3. PMID: 21051741.
      View in: PubMed
    19. Deng A, Arndt MA, Satriano J, Singh P, Rieg T, Thomson S, Tang T, Blantz RC. Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1365-73. PMID: 20881034; PMCID: PMC3006314.
    20. Vallon V, Platt KA, Cunard R, Schroth J, Whaley J, Thomson S, Koepsell H, Rieg T. SGLT2 mediates glucose reabsorption in the early proximal tubule. J Am Soc Nephrol. 2011 Jan; 22(1):104-12. PMID: 20616166; PMCID: PMC3014039.
    21. Satriano J, Mansoury H, Deng A, Sharma K, Vallon V, Blantz RC, Thomson S. Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes. Am J Physiol Cell Physiol. 2010 Aug; 299(2):C374-80. PMID: 20505038.
      View in: PubMed
    22. Singh P, Thomson S. Renal homeostasis and tubuloglomerular feedback. Curr Opin Nephrol Hypertens. 2010 Jan; 19(1):59-64. PMID: 19864948.
      View in: PubMed
    23. Deng A, Thomson S. Renal NMDA receptors independently stimulate proximal reabsorption and glomerular filtration. Am J Physiol Renal Physiol. 2009 May; 296(5):F976-82. PMID: 19279130; PMCID: PMC2681359.
    24. Vallon V, Schroth J, Satriano J, Blantz RC, Thomson S, Rieg T. Adenosine A(1) receptors determine glomerular hyperfiltration and the salt paradox in early streptozotocin diabetes mellitus. Nephron Physiol. 2009; 111(3):p30-8. PMID: 19276628; PMCID: PMC2904473.
    25. Singh P, Deng A, Blantz RC, Thomson S. Unexpected effect of angiotensin AT1 receptor blockade on tubuloglomerular feedback in early subtotal nephrectomy. Am J Physiol Renal Physiol. 2009 May; 296(5):F1158-65. PMID: 19211684; PMCID: PMC2681370.
    26. Deng A, Tang T, Singh P, Wang C, Satriano J, Thomson S, Blantz RC. Regulation of oxygen utilization by angiotensin II in chronic kidney disease. Kidney Int. 2009 Jan; 75(2):197-204. PMID: 18818681; PMCID: PMC3151651.
    27. Miracle CM, Rieg T, Mansoury H, Vallon V, Thomson S. Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt. Am J Physiol Renal Physiol. 2008 Oct; 295(4):F995-F1002. PMID: 18562630; PMCID: PMC2576161.
    28. Ruiz M, Singh P, Thomson S, Munger K, Blantz RC, Gabbai FB. L-arginine-induced glomerular hyperfiltration response: the roles of insulin and ANG II. Am J Physiol Regul Integr Comp Physiol. 2008 May; 294(5):R1744-51. PMID: 18353876.
      View in: PubMed
    29. Thomson S, Blantz RC. Glomerulotubular balance, tubuloglomerular feedback, and salt homeostasis. J Am Soc Nephrol. 2008 Dec; 19(12):2272-5. PMID: 18322161.
      View in: PubMed
    30. Vallon V, Miracle C, Thomson S. Adenosine and kidney function: potential implications in patients with heart failure. Eur J Heart Fail. 2008 Feb; 10(2):176-87. PMID: 18242127; PMCID: PMC3151609.
    31. Dittrich HC, Gupta DK, Hack TC, Dowling T, Callahan J, Thomson S. The effect of KW-3902, an adenosine A1 receptor antagonist, on renal function and renal plasma flow in ambulatory patients with heart failure and renal impairment. J Card Fail. 2007 Oct; 13(8):609-17. PMID: 17923351.
      View in: PubMed
    32. Miracle CM, Rieg T, Blantz RC, Vallon V, Thomson S. Combined effects of carbonic anhydrase inhibitor and adenosine A1 receptor antagonist on hemodynamic and tubular function in the kidney. Kidney Blood Press Res. 2007; 30(6):388-99. PMID: 17890869; PMCID: PMC2814144.
    33. Blantz RC, Deng A, Miracle CM, Thomson S. Regulation of kidney function and metabolism: a question of supply and demand. Trans Am Clin Climatol Assoc. 2007; 118:23-43. PMID: 18528487; PMCID: PMC1863590.
    34. Satriano J, Wead L, Cardus A, Deng A, Boss GR, Thomson S, Blantz RC. Regulation of ecto-5'-nucleotidase by NaCl and nitric oxide: potential roles in tubuloglomerular feedback and adaptation. Am J Physiol Renal Physiol. 2006 Nov; 291(5):F1078-82. PMID: 16705150.
      View in: PubMed
    35. Thomson S, Deng A, Wead L, Richter K, Blantz RC, Vallon V. An unexpected role for angiotensin II in the link between dietary salt and proximal reabsorption. J Clin Invest. 2006 Apr; 116(4):1110-6. PMID: 16557296; PMCID: PMC1409739.
    36. Deng A, Miracle CM, Lortie M, Satriano J, Gabbai FB, Munger KA, Thomson S, Blantz RC. Kidney oxygen consumption, carbonic anhydrase, and proton secretion. Am J Physiol Renal Physiol. 2006 May; 290(5):F1009-15. PMID: 16352743.
      View in: PubMed
    37. Deng A, Miracle CM, Suarez JM, Lortie M, Satriano J, Thomson S, Munger KA, Blantz RC. Oxygen consumption in the kidney: effects of nitric oxide synthase isoforms and angiotensin II. Kidney Int. 2005 Aug; 68(2):723-30. PMID: 16014049.
      View in: PubMed
    38. Vallon V, Blantz R, Thomson S. The salt paradox and its possible implications in managing hypertensive diabetic patients. Curr Hypertens Rep. 2005 Apr; 7(2):141-7. PMID: 15748540.
      View in: PubMed
    39. Lortie MJ, Satriano J, Gabbai FB, Thareau S, Khang S, Deng A, Pizzo DP, Thomson S, Blantz RC, Munger KA. Production of arginine by the kidney is impaired in a model of sepsis: early events following LPS. Am J Physiol Regul Integr Comp Physiol. 2004 Dec; 287(6):R1434-40. PMID: 15308488.
      View in: PubMed
    40. Slomowitz LA, Gabbai FB, Khang SJ, Satriano J, Thareau S, Deng A, Thomson S, Blantz RC, Munger KA. Protein intake regulates the vasodilatory function of the kidney and NMDA receptor expression. Am J Physiol Regul Integr Comp Physiol. 2004 Nov; 287(5):R1184-9. PMID: 15242825.
      View in: PubMed
    41. Thomson S, Deng A, Komine N, Hammes JS, Blantz RC, Gabbai FB. Early diabetes as a model for testing the regulation of juxtaglomerular NOS I. Am J Physiol Renal Physiol. 2004 Oct; 287(4):F732-8. PMID: 15213066.
      View in: PubMed
    42. Thomson S, Vallon V, Blantz RC. Kidney function in early diabetes: the tubular hypothesis of glomerular filtration. Am J Physiol Renal Physiol. 2004 Jan; 286(1):F8-15. PMID: 14656757.
      View in: PubMed
    43. Thomson S. Commentary on...neuronal nitric oxide synthase: its role and regulation in macula densa cells. J Am Soc Nephrol. 2003 Oct; 14(10):2688-9. PMID: 14514751.
      View in: PubMed
    44. Deng A, Munger KA, Valdivielso JM, Satriano J, Lortie M, Blantz RC, Thomson S. Increased expression of ornithine decarboxylase in distal tubules of early diabetic rat kidneys: are polyamines paracrine hypertrophic factors? Diabetes. 2003 May; 52(5):1235-9. PMID: 12716758.
      View in: PubMed
    45. Vallon V, Blantz RC, Thomson S. Glomerular hyperfiltration and the salt paradox in early [corrected] type 1 diabetes mellitus: a tubulo-centric view. J Am Soc Nephrol. 2003 Feb; 14(2):530-7. PMID: 12538755.
      View in: PubMed
    46. Thomson S, Deng A. Cyclic GMP mediates influence of macula densa nitric oxide over tubuloglomerular feedback. Kidney Blood Press Res. 2003; 26(1):10-8. PMID: 12697972.
      View in: PubMed
    47. Deng A, Hammes JS, Thomson S. Hemodynamics of early tubuloglomerular feedback resetting during reduced proximal reabsorption. Kidney Int. 2002 Dec; 62(6):2136-43. PMID: 12427138.
      View in: PubMed
    48. Vallon V, Huang DY, Deng A, Richter K, Blantz RC, Thomson S. Salt-sensitivity of proximal reabsorption alters macula densa salt and explains the paradoxical effect of dietary salt on glomerular filtration rate in diabetes mellitus. J Am Soc Nephrol. 2002 Jul; 13(7):1865-71. PMID: 12089382.
      View in: PubMed
    49. Deng A, Valdivielso JM, Munger KA, Blantz RC, Thomson S. Vasodilatory N-methyl-D-aspartate receptors are constitutively expressed in rat kidney. J Am Soc Nephrol. 2002 May; 13(5):1381-4. PMID: 11961027.
      View in: PubMed
    50. Slomowitz LA, Deng A, Hammes JS, Gabbai F, Thomson S. Glomerulotubular balance, dietary protein, and the renal response to glycine in diabetic rats. Am J Physiol Regul Integr Comp Physiol. 2002 Apr; 282(4):R1096-103. PMID: 11893614.
      View in: PubMed
    51. Gabbai FB, Hammond TC, Thomson S, Khang S, Kelly CJ. Effect of acute iNOS inhibition on glomerular function in tubulointerstitial nephritis. Kidney Int. 2002 Mar; 61(3):851-4. PMID: 11849437.
      View in: PubMed
    52. Blantz RC, Deng A, Lortie M, Munger K, Vallon V, Gabbai FB, Thomson S. The complex role of nitric oxide in the regulation of glomerular ultrafiltration. Kidney Int. 2002 Mar; 61(3):782-5. PMID: 11849425.
      View in: PubMed
    53. Thomson S. Adenosine and purinergic mediators of tubuloglomerular feedback. Curr Opin Nephrol Hypertens. 2002 Jan; 11(1):81-6. PMID: 11753091.
      View in: PubMed
    54. Thomson S, Deng A, Bao D, Satriano J, Blantz RC, Vallon V. Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes. J Clin Invest. 2001 Jan; 107(2):217-24. PMID: 11160138; PMCID: PMC199175.
    55. Thomson S, Bao D, Deng A, Vallon V. Adenosine formed by 5'-nucleotidase mediates tubuloglomerular feedback. J Clin Invest. 2000 Jul; 106(2):289-98. PMID: 10903345; PMCID: PMC314305.
    56. Thomson S, Bachmann S, Bostanjoglo M, Ecelbarger CA, Peterson OW, Schwartz D, Bao D, Blantz RC. Temporal adjustment of the juxtaglomerular apparatus during sustained inhibition of proximal reabsorption. J Clin Invest. 1999 Oct; 104(8):1149-58. PMID: 10525054; PMCID: PMC408569.
    57. Thomson S, Vallon V, Blantz RC. Resetting protects efficiency of tubuloglomerular feedback. Kidney Int Suppl. 1998 Sep; 67:S65-70. PMID: 9736256.
      View in: PubMed