Xu Chen

Title(s)Assistant Professor In Residence, Neurosciences
SchoolVc-health Sciences-schools
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    Collapse Biography 
    Collapse Awards and Honors
    Alzheimer’s Association2016Awards for Excellence in Alzheimer’s Research
    Genetic Society of America 2010DeLill Nasser Award for Professional Development in Genetics

    Collapse Overview 
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Role of Testosterone in Modulating Tau Pathogenesis in Females
    NIH R01AG078185Sep 1, 2022 - May 31, 2027
    Role: Principal Investigator
    Mechanisms by which the ketone body ß-hydroxybutyrate counteracts tau pathogenesis
    NIH R01AG074273May 1, 2022 - Feb 28, 2027
    Role: Principal Investigator
    The Role of Chromogranin A in Tauopathy
    NIH R21AG072487May 1, 2021 - Apr 30, 2023
    Role: Co-Principal Investigator
    UCSD Alzheimer's Disease Research Centers P30
    NIH P30AG062429May 1, 2019 - Mar 31, 2024
    Role: Co-Investigator
    Metabolic Regulation of Neurodegeneration in Tauopathy
    NIH K99AG053439Aug 1, 2016 - May 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus. Neurobiol Dis. 2022 10 01; 172:105834. Ojeda-Juárez D, Lawrence JA, Soldau K, Pizzo DP, Wheeler E, Aguilar-Calvo P, Khuu H, Chen J, Malik A, Funk G, Nam P, Sanchez H, Geschwind MD, Wu C, Yeo GW, Chen X, Patrick GN, Sigurdson CJ. PMID: 35905927.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms. Cell Metab. 2022 05 03; 34(5):651-653. Chen X, Calandrelli R, Girardini J, Yan Z, Tan Z, Xu X, Hiniker A, Zhong S. PMID: 35508105; PMCID: PMC9531314.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell. 2022 02 17; 185(4):712-728.e14. Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, Telpoukhovskaia M, Min SW, Wang C, Sohn PD, Martin J, Zhou Y, Luo W, Trojanowski JQ, Lee VMY, Gong S, Manfredi G, Coppola G, Krogan NJ, Geschwind DH, Gan L. PMID: 35063084; PMCID: PMC8857049.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    4. Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nat Commun. 2021 04 14; 12(1):2238. Caballero B, Bourdenx M, Luengo E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegmann S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, Karch CM, Goate AM, Gestwicki JE, Hyman BT, Gan L, Cuervo AM. PMID: 33854069; PMCID: PMC8047017.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    5. Sex differences in Alzheimer's-related Tau biomarkers and a mediating effect of testosterone. Biol Sex Differ. 2020 06 19; 11(1):33. Sundermann EE, Panizzon MS, Chen X, Andrews M, Galasko D, Banks SJ, Alzheimer’s Disease Neuroimaging Initiative. PMID: 32560743; PMCID: PMC7304096.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    6. Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):8154-8165. Chakraborty A, Tapryal N, Venkova T, Mitra J, Vasquez V, Sarker AH, Duarte-Silva S, Huai W, Ashizawa T, Ghosh G, Maciel P, Sarkar PS, Hegde ML, Chen X, Hazra TK. PMID: 32205441; PMCID: PMC7148577.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    7. Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. Mol Neurodegener. 2020 01 06; 15(1):2. Chen X, Li Y, Wang C, Tang Y, Mok SA, Tsai RM, Rojas JC, Karydas A, Miller BL, Boxer AL, Gestwicki JE, Arkin M, Cuervo AM, Gan L. PMID: 31906970; PMCID: PMC6945522.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    8. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models. Nat Med. 2019 01; 25(1):165-175. Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gonçalves RA, Clarke JR, Beckman D, Staniszewski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Wilcock DM, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Abisambra JF, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG. PMID: 30617325; PMCID: PMC6327967.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansAnimalsCells
    9. Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases. Curr Opin Neurobiol. 2018 02; 48:52-58. Wang C, Telpoukhovskaia MA, Bahr BA, Chen X, Gan L. PMID: 29028540.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    10. Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem Cell Reports. 2017 10 10; 9(4):1221-1233. Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L. PMID: 28966121; PMCID: PMC5639430.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    11. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med. 2015 Oct; 21(10):1154-62. Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. PMID: 26390242; PMCID: PMC4598295.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansAnimalsCells
    12. Drosulfakinin activates CCKLR-17D1 and promotes larval locomotion and escape response in Drosophila. Fly (Austin). 2012 Oct-Dec; 6(4):290-7. Chen X, Peterson J, Nachman RJ, Ganetzky B. PMID: 22885328; PMCID: PMC3519664.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    13. A neuropeptide signaling pathway regulates synaptic growth in Drosophila. J Cell Biol. 2012 Feb 20; 196(4):529-43. Chen X, Ganetzky B. PMID: 22331845; PMCID: PMC3283997.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
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