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    Shelley Halpain

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentNeurobiology
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    Phone858-822-7793
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      Collapse Research 
      Collapse Research Activities and Funding
      Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana)
      NIH/NIMH U19MH107367Sep 21, 2015 - Jun 30, 2020
      Role: Co-Investigator
      Mechanisms of Dendritic Spine Stability
      NIH/NIMH R01MH087823Dec 4, 2009 - Nov 30, 2015
      Role: Principal Investigator
      High Content Screens of Neuronal Development for Autism Research
      NIH/NINDS R21NS070297Sep 30, 2009 - Aug 31, 2011
      Role: Principal Investigator
      "Cell Biology of the Neuron" Gordon Conference
      NIH/NIMH R13MH065972Jul 1, 2002 - Jun 30, 2007
      Role: Principal Investigator
      REGULATION OF DENDRITIC SPINES
      NIH/NINDS R01NS037311Feb 3, 1999 - Jan 31, 2004
      Role: Principal Investigator
      AGING AND THE NEURONAL CYTOSKELETON
      NIH/NIA R03AG014549Mar 1, 1997 - Feb 28, 1999
      Role: Principal Investigator
      Comprehensive Biology: Exploiting the Yeast Genome
      NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
      Role: Co-Investigator
      Cytoskeletal Targets of Neuronal Signaling
      NIH/NIMH R01MH050861Feb 1, 1994 - Oct 1, 2007
      Role: Principal Investigator
      CYTOSKELETAL TARGETS OF NEURONAL SIGNALING
      NIH/NIMH R29MH050861Feb 1, 1994 - Jan 31, 1999
      Role: Principal Investigator
      Administrative Core
      NIH/NIMH U19MH-01
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Tobe BTD, Crain AM, Winquist AM, Calabrese B, Makihara H, Zhao WN, Lalonde J, Nakamura H, Konopaske G, Sidor M, Pernia CD, Yamashita N, Wada M, Inoue Y, Nakamura F, Sheridan SD, Logan RW, Brandel M, Wu D, Hunsberger J, Dorsett L, Duerr C, Basa RCB, McCarthy MJ, Udeshi ND, Mertins P, Carr SA, Rouleau GA, Mastrangelo L, Li J, Gutierrez GJ, Brill LM, Venizelos N, Chen G, Nye JS, Manji H, Price JH, McClung CA, Akiskal HS, Alda M, Chuang DM, Coyle JT, Liu Y, Teng YD, Ohshima T, Mikoshiba K, Sidman RL, Halpain S, Haggarty SJ, Goshima Y, Snyder EY. Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. Proc Natl Acad Sci U S A. 2017 May 30; 114(22):E4462-E4471. PMID: 28500272.
        View in: PubMed
      2. Calabrese B, Halpain S. Differential targeting of dynamin-1 and dynamin-3 to nerve terminals during chronic suppression of neuronal activity. Mol Cell Neurosci. 2015 Sep; 68:36-45. PMID: 25827095; PMCID: PMC4584186.
      3. Calabrese B, Halpain S. Lithium prevents aberrant NMDA-induced F-actin reorganization in neurons. Neuroreport. 2014 Dec 03; 25(17):1331-7. PMID: 25304495; PMCID: PMC4213241.
      4. Platholi J, Herold KF, Hemmings HC, Halpain S. Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism. PLoS One. 2014; 9(7):e102978. PMID: 25068870; PMCID: PMC4113311.
      5. Sinnar SA, Antoku S, Saffin JM, Cooper JA, Halpain S. Capping protein is essential for cell migration in vivo and for filopodial morphology and dynamics. Mol Biol Cell. 2014 Jul 15; 25(14):2152-60. PMID: 24829386; PMCID: PMC4091828.
      6. Calabrese B, Saffin JM, Halpain S. Activity-dependent dendritic spine shrinkage and growth involve downregulation of cofilin via distinct mechanisms. PLoS One. 2014; 9(4):e94787. PMID: 24740405; PMCID: PMC3989342.
      7. Sontag JM, Nunbhakdi-Craig V, White CL, Halpain S, Sontag E. The protein phosphatase PP2A/Ba binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. J Biol Chem. 2012 Apr 27; 287(18):14984-93. PMID: 22403409; PMCID: PMC3340226.
      8. Dehmelt L, Poplawski G, Hwang E, Halpain S. NeuriteQuant: an open source toolkit for high content screens of neuronal morphogenesis. BMC Neurosci. 2011 Oct 11; 12:100. PMID: 21989414; PMCID: PMC3208608.
      9. Fath T, Fischer RS, Dehmelt L, Halpain S, Fowler VM. Tropomodulins are negative regulators of neurite outgrowth. Eur J Cell Biol. 2011 Apr; 90(4):291-300. PMID: 21146252; PMCID: PMC3042488.
      10. Barros CS, Calabrese B, Chamero P, Roberts AJ, Korzus E, Lloyd K, Stowers L, Mayford M, Halpain S, Müller U. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4507-12. PMID: 19240213; PMCID: PMC2657442.
      11. Dehmelt L, Halpain S. Neurite outgrowth: a flick of the wrist. Curr Biol. 2007 Aug 07; 17(15):R611-4. PMID: 17686437.
        View in: PubMed
      12. Al-Bassam J, Roger B, Halpain S, Milligan RA. Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c. Cell Motil Cytoskeleton. 2007 May; 64(5):377-89. PMID: 17326138.
        View in: PubMed
      13. Dehmelt L, Nalbant P, Steffen W, Halpain S. A microtubule-based, dynein-dependent force induces local cell protrusions: Implications for neurite initiation. Brain Cell Biol. 2006 Feb; 35(1):39-56. PMID: 17940912.
        View in: PubMed
      14. Calabrese B, Shaked GM, Tabarean IV, Braga J, Koo EH, Halpain S. Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein. Mol Cell Neurosci. 2007 Jun; 35(2):183-93. PMID: 17368908; PMCID: PMC2268524.
      15. Halpain S. They're plastic, but they recycle. Neuron. 2006 Dec 07; 52(5):746-8. PMID: 17145496.
        View in: PubMed
      16. Calabrese B, Wilson MS, Halpain S. Development and regulation of dendritic spine synapses. Physiology (Bethesda). 2006 Feb; 21:38-47. PMID: 16443821.
        View in: PubMed
      17. Halpain S, Dehmelt L. The MAP1 family of microtubule-associated proteins. Genome Biol. 2006; 7(6):224. PMID: 16938900; PMCID: PMC1779536.
      18. Calabrese B, Halpain S. Essential role for the PKC target MARCKS in maintaining dendritic spine morphology. Neuron. 2005 Oct 06; 48(1):77-90. PMID: 16202710.
        View in: PubMed
      19. Halpain S, Spencer K, Graber S. Dynamics and pathology of dendritic spines. Prog Brain Res. 2005; 147:29-37. PMID: 15581695.
        View in: PubMed
      20. Dehmelt L, Halpain S. The MAP2/Tau family of microtubule-associated proteins. Genome Biol. 2005; 6(1):204. PMID: 15642108; PMCID: PMC549057.
      21. Graber S, Maiti S, Halpain S. Cathepsin B-like proteolysis and MARCKS degradation in sub-lethal NMDA-induced collapse of dendritic spines. Neuropharmacology. 2004 Oct; 47(5):706-13. PMID: 15458842.
        View in: PubMed
      22. Roger B, Al-Bassam J, Dehmelt L, Milligan RA, Halpain S. MAP2c, but not tau, binds and bundles F-actin via its microtubule binding domain. Curr Biol. 2004 Mar 09; 14(5):363-71. PMID: 15028210.
        View in: PubMed
      23. Dehmelt L, Halpain S. Actin and microtubules in neurite initiation: are MAPs the missing link? J Neurobiol. 2004 Jan; 58(1):18-33. PMID: 14598367.
        View in: PubMed
      24. Dehmelt L, Smart FM, Ozer RS, Halpain S. The role of microtubule-associated protein 2c in the reorganization of microtubules and lamellipodia during neurite initiation. J Neurosci. 2003 Oct 22; 23(29):9479-90. PMID: 14573527.
        View in: PubMed
      25. Halpain S. Actin in a supporting role. Nat Neurosci. 2003 Feb; 6(2):101-2. PMID: 12555098.
        View in: PubMed
      26. Malmendal A, Halpain S, Chazin WJ. Nascent structure in the kinase anchoring domain of microtubule-associated protein 2. Biochem Biophys Res Commun. 2003 Jan 31; 301(1):136-42. PMID: 12535652.
        View in: PubMed
      27. Halpain S. Making new connections. Trends Cell Biol. 2002 Oct; 12(10):455-7. PMID: 12441241.
        View in: PubMed
      28. Al-Bassam J, Ozer RS, Safer D, Halpain S, Milligan RA. MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments. J Cell Biol. 2002 Jun 24; 157(7):1187-96. PMID: 12082079; PMCID: PMC2173547.
      29. Ozer RS, Halpain S. Phosphorylation-dependent localization of microtubule-associated protein MAP2c to the actin cytoskeleton. Mol Biol Cell. 2000 Oct; 11(10):3573-87. PMID: 11029056; PMCID: PMC15014.
      30. Lim RW, Halpain S. Regulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding protein. J Biol Chem. 2000 Jul 07; 275(27):20578-87. PMID: 10781592.
        View in: PubMed
      31. Krucker T, Siggins GR, Halpain S. Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6856-61. PMID: 10823894; PMCID: PMC18765.
      32. Halpain S. Actin and the agile spine: how and why do dendritic spines dance? Trends Neurosci. 2000 Apr; 23(4):141-6. PMID: 10717670.
        View in: PubMed
      33. Smart FM, Halpain S. Regulation of dendritic spine stability. Hippocampus. 2000; 10(5):542-54. PMID: 11075824.
        View in: PubMed
      34. Steward O, Halpain S. Lamina-specific synaptic activation causes domain-specific alterations in dendritic immunostaining for MAP2 and CAM kinase II. J Neurosci. 1999 Sep 15; 19(18):7834-45. PMID: 10479686.
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      35. Halpain S, Hipolito A, Saffer L. Regulation of F-actin stability in dendritic spines by glutamate receptors and calcineurin. J Neurosci. 1998 Dec 01; 18(23):9835-44. PMID: 9822742.
        View in: PubMed
      36. Norris CM, Halpain S, Foster TC. Alterations in the balance of protein kinase/phosphatase activities parallel reduced synaptic strength during aging. J Neurophysiol. 1998 Sep; 80(3):1567-70. PMID: 9744962.
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      37. Norris CM, Halpain S, Foster TC. Reversal of age-related alterations in synaptic plasticity by blockade of L-type Ca2+ channels. J Neurosci. 1998 May 01; 18(9):3171-9. PMID: 9547225.
        View in: PubMed
      38. Philpot BD, Lim JH, Halpain S, Brunjes PC. Experience-dependent modifications in MAP2 phosphorylation in rat olfactory bulb. J Neurosci. 1997 Dec 15; 17(24):9596-604. PMID: 9391014.
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      39. Quinlan EM, Halpain S. Emergence of activity-dependent, bidirectional control of microtubule-associated protein MAP2 phosphorylation during postnatal development. J Neurosci. 1996 Dec 01; 16(23):7627-37. PMID: 8922419.
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      40. Gamblin TC, Nachmanoff K, Halpain S, Williams RC. Recombinant microtubule-associated protein 2c reduces the dynamic instability of individual microtubules. Biochemistry. 1996 Sep 24; 35(38):12576-86. PMID: 8823195.
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      41. Burack MA, Halpain S. Site-specific regulation of Alzheimer-like tau phosphorylation in living neurons. Neuroscience. 1996 May; 72(1):167-84. PMID: 8730715.
        View in: PubMed
      42. Quinlan EM, Halpain S. Postsynaptic mechanisms for bidirectional control of MAP2 phosphorylation by glutamate receptors. Neuron. 1996 Feb; 16(2):357-68. PMID: 8789950.
        View in: PubMed
      43. Plautz JD, Day RN, Dailey GM, Welsh SB, Hall JC, Halpain S, Kay SA. Green fluorescent protein and its derivatives as versatile markers for gene expression in living Drosophila melanogaster, plant and mammalian cells. Gene. 1996; 173(1 Spec No):83-7. PMID: 8707061.
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      44. Halpain S, Greengard P. Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2. Neuron. 1990 Sep; 5(3):237-46. PMID: 2169265.
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      45. Girault JA, Halpain S, Greengard P. Excitatory amino acid antagonists and Parkinson's disease. Trends Neurosci. 1990 Aug; 13(8):325-7. PMID: 1699316.
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      46. Halpain S, Girault JA, Greengard P. Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices. Nature. 1990 Jan 25; 343(6256):369-72. PMID: 2153935.
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      47. Brose N, Halpain S, Suchanek C, Jahn R. Characterization and partial purification of a chloride- and calcium-dependent glutamate-binding protein from rat brain. J Biol Chem. 1989 Jun 05; 264(16):9619-25. PMID: 2566612.
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      48. Halpain S, McEwen BS. Corticosterone decreases 3H-glutamate binding in rat hippocampal formation. Neuroendocrinology. 1988 Sep; 48(3):235-41. PMID: 2903460.
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      49. Dohanich GP, Halpain S, Lambdin LT, McEwen BS. Features of ligand binding in homogenate and section preparations. Brain Res. 1986 Feb 26; 366(1-2):338-42. PMID: 3697689.
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      50. Halpain S, Spanier T, McEwen BS. Loss of 3H-corticosterone binding capacity in hippocampal slices maintained in vitro. Brain Res Bull. 1986 Feb; 16(2):167-70. PMID: 3697785.
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      51. Halpain S, Wieczorek CM, Rainbow TC. Localization of L-glutamate receptors in rat brain by quantitative autoradiography. J Neurosci. 1984 Sep; 4(9):2247-58. PMID: 6090612.
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      52. Rainbow TC, Wieczorek CM, Halpain S. Quantitative autoradiography of binding sites for [3H]AMPA, a structural analogue of glutamic acid. Brain Res. 1984 Aug 20; 309(1):173-7. PMID: 6091846.
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      53. Lynch G, Kessler M, Halpain S, Baudry M. Biochemical effects of high-frequency synaptic activity studied with in vitro slices. Fed Proc. 1983 Sep; 42(12):2886-90. PMID: 6136422.
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      54. Halpain S, Parsons B, Rainbow TC. Tritium-film autoradiography of sodium-independent glutamate binding sites in rat brain. Eur J Pharmacol. 1982 Dec 24; 86(2):313-4. PMID: 6297937.
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      55. Lynch G, Halpain S, Baudry M. Effects of high-frequency synaptic stimulation on glumate receptor binding studied with a modified in vitro hippocampal slice preparation. Brain Res. 1982 Jul 22; 244(1):101-11. PMID: 6126257.
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