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James Posakony

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentCell and Developmental Biology
Address9500 Gilman Drive #0349
La Jolla CA 92093
Phone858-534-6300
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    Collapse Research 
    Collapse Research Activities and Funding
    Functional Architecture of Developmental Cis-Regulatory Modules
    NIH/NIGMS R01GM120377May 15, 2017 - Feb 28, 2021
    Role: Principal Investigator
    THE NOTCH SIGNALING PATHWAY: STRUCTURE AND MECHANISM
    NIH/NIGMS R01GM075270Aug 1, 2005 - Jul 31, 2010
    Role: Principal Investigator
    Cell Fate--The Specification/Differentiation Interface
    NIH/NIGMS R01GM062279Jul 1, 2001 - Jun 30, 2005
    Role: Principal Investigator
    Molecular Genetics of Sensory Organ Development
    NIH/NIGMS R01GM046993Feb 1, 1992 - Jun 30, 2016
    Role: Principal Investigator
    TRANSCRIPTIONAL CONTROL IN EMBRYONIC PATTERN FORMATION
    NIH/NIGMS R01GM041100Aug 1, 1988 - Jul 31, 1994
    Role: Principal Investigator
    THE REGULATED EXPRESSION OF THE DROSOPHILA ADH GENE
    NIH/NIGMS R01GM035246Aug 1, 1985 - Jul 31, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Miller SW, Posakony JW. Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized. PLoS Genet. 2018 Jul 20; 14(7):e1007528. PMID: 30028887.
      View in: PubMed
    2. Smith AF, Posakony JW, Rebeiz M. Automated tools for comparative sequence analysis of genic regions using the GenePalette application. Dev Biol. 2017 09 01; 429(1):158-164. PMID: 28673819.
      View in: PubMed
    3. Miller SW, Rebeiz M, Atanasov JE, Posakony JW. Neural precursor-specific expression of multiple Drosophila genes is driven by dual enhancer modules with overlapping function. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17194-9. PMID: 25404315; PMCID: PMC4260543.
    4. Liu F, Posakony JW. An enhancer composed of interlocking submodules controls transcriptional autoregulation of suppressor of hairless. Dev Cell. 2014 Apr 14; 29(1):88-101. PMID: 24735880; PMCID: PMC4013524.
    5. Liu F, Posakony JW. Role of architecture in the function and specificity of two Notch-regulated transcriptional enhancer modules. PLoS Genet. 2012 Jul; 8(7):e1002796. PMID: 22792075; PMCID: PMC3390367.
    6. Rebeiz M, Castro B, Liu F, Yue F, Posakony JW. Ancestral and conserved cis-regulatory architectures in developmental control genes. Dev Biol. 2012 Feb 15; 362(2):282-94. PMID: 22185795; PMCID: PMC3265639.
    7. Hirono K, Margolis JS, Posakony JW, Doe CQ. Identification of hunchback cis-regulatory DNA conferring temporal expression in neuroblasts and neurons. Gene Expr Patterns. 2012 Jan-Feb; 12(1-2):11-7. PMID: 22033538; PMCID: PMC3272097.
    8. Nègre N, Brown CD, Ma L, Bristow CA, Miller SW, Wagner U, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony RF, Chen J, Hwang L, Cheng C, Auburn RP, Davis MB, Domanus M, Shah PK, Morrison CA, Zieba J, Suchy S, Senderowicz L, Victorsen A, Bild NA, Grundstad AJ, Hanley D, MacAlpine DM, Mannervik M, Venken K, Bellen H, White R, Gerstein M, Russell S, Grossman RL, Ren B, Posakony JW, Kellis M, White KP. A cis-regulatory map of the Drosophila genome. Nature. 2011 Mar 24; 471(7339):527-31. PMID: 21430782; PMCID: PMC3179250.
    9. Zhou D, Udpa N, Gersten M, Visk DW, Bashir A, Xue J, Frazer KA, Posakony JW, Subramaniam S, Bafna V, Haddad GG. Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2349-54. PMID: 21262834; PMCID: PMC3038716.
    10. Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science. 2010 Dec 24; 330(6012):1787-97. PMID: 21177974.
      View in: PubMed
    11. Rebeiz M, Miller SW, Posakony JW. Notch regulates numb: integration of conditional and autonomous cell fate specification. Development. 2011 Jan; 138(2):215-25. PMID: 21148185; PMCID: PMC3005598.
    12. Fontana JR, Posakony JW. Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta. Dev Biol. 2009 Sep 15; 333(2):373-85. PMID: 19580805; PMCID: PMC2793682.
    13. Miller SW, Avidor-Reiss T, Polyanovsky A, Posakony JW. Complex interplay of three transcription factors in controlling the tormogen differentiation program of Drosophila mechanoreceptors. Dev Biol. 2009 May 15; 329(2):386-99. PMID: 19232522; PMCID: PMC2762865.
    14. Tsai YC, Yao JG, Chen PH, Posakony JW, Barolo S, Kim J, Sun YH. Upd/Jak/STAT signaling represses wg transcription to allow initiation of morphogenetic furrow in Drosophila eye development. Dev Biol. 2007 Jun 15; 306(2):760-71. PMID: 17498684.
      View in: PubMed
    15. Ocorr K, Reeves NL, Wessells RJ, Fink M, Chen HS, Akasaka T, Yasuda S, Metzger JM, Giles W, Posakony JW, Bodmer R. KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3943-8. PMID: 17360457; PMCID: PMC1820688.
    16. Castro B, Barolo S, Bailey AM, Posakony JW. Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless. Development. 2005 Aug; 132(15):3333-44. PMID: 15975935.
      View in: PubMed
    17. Rebeiz M, Stone T, Posakony JW. An ancient transcriptional regulatory linkage. Dev Biol. 2005 May 15; 281(2):299-308. PMID: 15893980.
      View in: PubMed
    18. Reeves N, Posakony JW. Genetic programs activated by proneural proteins in the developing Drosophila PNS. Dev Cell. 2005 Mar; 8(3):413-25. PMID: 15737936.
      View in: PubMed
    19. Rebeiz M, Posakony JW. GenePalette: a universal software tool for genome sequence visualization and analysis. Dev Biol. 2004 Jul 15; 271(2):431-8. PMID: 15223345.
      View in: PubMed
    20. Barolo S, Castro B, Posakony JW. New Drosophila transgenic reporters: insulated P-element vectors expressing fast-maturing RFP. Biotechniques. 2004 Mar; 36(3):436-40, 442. PMID: 15038159.
      View in: PubMed
    21. Barolo S, Stone T, Bang AG, Posakony JW. Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. Genes Dev. 2002 Aug 01; 16(15):1964-76. PMID: 12154126; PMCID: PMC186408.
    22. Rebeiz M, Reeves NL, Posakony JW. SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Site clustering over random expectation. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9888-93. PMID: 12107285; PMCID: PMC125053.
    23. Barolo S, Posakony JW. Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling. Genes Dev. 2002 May 15; 16(10):1167-81. PMID: 12023297.
      View in: PubMed