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Disparate expression specificities coded by a shared Hox-C enhancer. Elife. 2020 04 28; 9.
Miller SW, Posakony JW. PMID: 32342858; PMCID: PMC7188484.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway. Elife. 2019 09 23; 8.
Miller SW, Movsesyan A, Zhang S, Fernández R, Posakony JW. PMID: 31545167; PMCID: PMC6777938.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized. PLoS Genet. 2018 07; 14(7):e1007528.
Miller SW, Posakony JW. PMID: 30028887; PMCID: PMC6070291.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Automated tools for comparative sequence analysis of genic regions using the GenePalette application. Dev Biol. 2017 09 01; 429(1):158-164.
Smith AF, Posakony JW, Rebeiz M. PMID: 28673819; PMCID: PMC5623810.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Neural precursor-specific expression of multiple Drosophila genes is driven by dual enhancer modules with overlapping function. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17194-9.
Miller SW, Rebeiz M, Atanasov JE, Posakony JW. PMID: 25404315; PMCID: PMC4260543.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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An enhancer composed of interlocking submodules controls transcriptional autoregulation of suppressor of hairless. Dev Cell. 2014 Apr 14; 29(1):88-101.
Liu F, Posakony JW. PMID: 24735880; PMCID: PMC4013524.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Role of architecture in the function and specificity of two Notch-regulated transcriptional enhancer modules. PLoS Genet. 2012 Jul; 8(7):e1002796.
Liu F, Posakony JW. PMID: 22792075; PMCID: PMC3390367.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Ancestral and conserved cis-regulatory architectures in developmental control genes. Dev Biol. 2012 Feb 15; 362(2):282-94.
Rebeiz M, Castro B, Liu F, Yue F, Posakony JW. PMID: 22185795; PMCID: PMC3265639.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Identification of hunchback cis-regulatory DNA conferring temporal expression in neuroblasts and neurons. Gene Expr Patterns. 2012 Jan-Feb; 12(1-2):11-7.
Hirono K, Margolis JS, Posakony JW, Doe CQ. PMID: 22033538; PMCID: PMC3272097.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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A cis-regulatory map of the Drosophila genome. Nature. 2011 Mar 24; 471(7339):527-31.
Nègre N, Brown CD, Ma L, Bristow CA, Miller SW, Wagner U, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony RF, Chen J, Hwang L, Cheng C, Auburn RP, Davis MB, Domanus M, Shah PK, Morrison CA, Zieba J, Suchy S, Senderowicz L, Victorsen A, Bild NA, Grundstad AJ, Hanley D, MacAlpine DM, Mannervik M, Venken K, Bellen H, White R, Gerstein M, Russell S, Grossman RL, Ren B, Posakony JW, Kellis M, White KP. PMID: 21430782; PMCID: PMC3179250.
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PubMed Mentions:
315 Fields:
Translation:
AnimalsCells
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Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2349-54.
Zhou D, Udpa N, Gersten M, Visk DW, Bashir A, Xue J, Frazer KA, Posakony JW, Subramaniam S, Bafna V, Haddad GG. PMID: 21262834; PMCID: PMC3038716.
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PubMed Mentions:
67 Fields:
Translation:
AnimalsCells
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Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science. 2010 Dec 24; 330(6012):1787-97.
modENCODE Consortium, Roy S, Ernst J, Kharchenko PV, Kheradpour P, Negre N, Eaton ML, Landolin JM, Bristow CA, Ma L, Lin MF, Washietl S, Arshinoff BI, Ay F, Meyer PE, Robine N, Washington NL, Di Stefano L, Berezikov E, Brown CD, Candeias R, Carlson JW, Carr A, Jungreis I, Marbach D, Sealfon R, Tolstorukov MY, Will S, Alekseyenko AA, Artieri C, Booth BW, Brooks AN, Dai Q, Davis CA, Duff MO, Feng X, Gorchakov AA, Gu T, Henikoff JG, Kapranov P, Li R, MacAlpine HK, Malone J, Minoda A, Nordman J, Okamura K, Perry M, Powell SK, Riddle NC, Sakai A, Samsonova A, Sandler JE, Schwartz YB, Sher N, Spokony R, Sturgill D, van Baren M, Wan KH, Yang L, Yu C, Feingold E, Good P, Guyer M, Lowdon R, Ahmad K, Andrews J, Berger B, Brenner SE, Brent MR, Cherbas L, Elgin SC, Gingeras TR, Grossman R, Hoskins RA, Kaufman TC, Kent W, Kuroda MI, Orr-Weaver T, Perrimon N, Pirrotta V, Posakony JW, Ren B, Russell S, Cherbas P, Graveley BR, Lewis S, Micklem G, Oliver B, Park PJ, Celniker SE, Henikoff S, Karpen GH, Lai EC, MacAlpine DM, Stein LD, White KP, Kellis M. PMID: 21177974; PMCID: PMC3192495.
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PubMed Mentions:
705 Fields:
Translation:
AnimalsCells
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Notch regulates numb: integration of conditional and autonomous cell fate specification. Development. 2011 Jan; 138(2):215-25.
Rebeiz M, Miller SW, Posakony JW. PMID: 21148185; PMCID: PMC3005598.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta. Dev Biol. 2009 Sep 15; 333(2):373-85.
Fontana JR, Posakony JW. PMID: 19580805; PMCID: PMC2793682.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Complex interplay of three transcription factors in controlling the tormogen differentiation program of Drosophila mechanoreceptors. Dev Biol. 2009 May 15; 329(2):386-99.
Miller SW, Avidor-Reiss T, Polyanovsky A, Posakony JW. PMID: 19232522; PMCID: PMC2762865.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Upd/Jak/STAT signaling represses wg transcription to allow initiation of morphogenetic furrow in Drosophila eye development. Dev Biol. 2007 Jun 15; 306(2):760-71.
Tsai YC, Yao JG, Chen PH, Posakony JW, Barolo S, Kim J, Sun YH. PMID: 17498684.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3943-8.
Ocorr K, Reeves NL, Wessells RJ, Fink M, Chen HS, Akasaka T, Yasuda S, Metzger JM, Giles W, Posakony JW, Bodmer R. PMID: 17360457; PMCID: PMC1820688.
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PubMed Mentions:
140 Fields:
Translation:
HumansAnimals
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Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless. Development. 2005 Aug; 132(15):3333-44.
Castro B, Barolo S, Bailey AM, Posakony JW. PMID: 15975935.
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PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
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An ancient transcriptional regulatory linkage. Dev Biol. 2005 May 15; 281(2):299-308.
Rebeiz M, Stone T, Posakony JW. PMID: 15893980.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Genetic programs activated by proneural proteins in the developing Drosophila PNS. Dev Cell. 2005 Mar; 8(3):413-25.
Reeves N, Posakony JW. PMID: 15737936.
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PubMed Mentions:
57 Fields:
Translation:
Animals
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GenePalette: a universal software tool for genome sequence visualization and analysis. Dev Biol. 2004 Jul 15; 271(2):431-8.
Rebeiz M, Posakony JW. PMID: 15223345.
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PubMed Mentions:
51 Fields:
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New Drosophila transgenic reporters: insulated P-element vectors expressing fast-maturing RFP. Biotechniques. 2004 Mar; 36(3):436-40, 442.
Barolo S, Castro B, Posakony JW. PMID: 15038159.
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PubMed Mentions:
108 Fields:
Translation:
AnimalsCells
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Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. Genes Dev. 2002 Aug 01; 16(15):1964-76.
Barolo S, Stone T, Bang AG, Posakony JW. PMID: 12154126; PMCID: PMC186408.
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PubMed Mentions:
96 Fields:
Translation:
AnimalsCells
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SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Site clustering over random expectation. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9888-93.
Rebeiz M, Reeves NL, Posakony JW. PMID: 12107285; PMCID: PMC125053.
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PubMed Mentions:
75 Fields:
Translation:
AnimalsCells
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Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling. Genes Dev. 2002 May 15; 16(10):1167-81.
Barolo S, Posakony JW. PMID: 12023297.
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PubMed Mentions:
185 Fields:
Translation:
HumansAnimalsCells
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A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology. Cell. 2000 Dec 08; 103(6):957-69.
Barolo S, Walker RG, Polyanovsky AD, Freschi G, Keil T, Posakony JW. PMID: 11136980.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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GFP and beta-galactosidase transformation vectors for promoter/enhancer analysis in Drosophila. Biotechniques. 2000 Oct; 29(4):726, 728, 730, 732.
Barolo S, Carver LA, Posakony JW. PMID: 11056799.
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PubMed Mentions:
197 Fields:
Translation:
AnimalsCells
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The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family. Development. 2000 Aug; 127(16):3441-55.
Lai EC, Bodner R, Posakony JW. PMID: 10903170.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes. Development. 2000 Jan; 127(2):291-306.
Lai EC, Bodner R, Kavaler J, Freschi G, Posakony JW. PMID: 10603347.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Dev Biol. 1999 Sep 01; 213(1):33-53.
Nellesen DT, Lai EC, Posakony JW. PMID: 10452845.
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PubMed Mentions:
82 Fields:
Translation:
AnimalsCells
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An essential role for the Drosophila Pax2 homolog in the differentiation of adult sensory organs. Development. 1999 May; 126(10):2261-72.
Kavaler J, Fu W, Duan H, Noll M, Posakony JW. PMID: 10207150.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Birds on a wire and tiling the inner ear. Nat Genet. 1999 Mar; 21(3):253-4.
Posakony JW. PMID: 10080171.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts. Development. 1998 Oct; 125(20):4077-88.
Lai EC, Burks C, Posakony JW. PMID: 9735368.
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PubMed Mentions:
75 Fields:
Translation:
AnimalsCells
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Regulation of Drosophila neurogenesis by RNA:RNA duplexes? Cell. 1998 Jun 26; 93(7):1103-4.
Lai EC, Posakony JW. PMID: 9657143.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression. Development. 1997 Dec; 124(23):4847-56.
Lai EC, Posakony JW. PMID: 9428421.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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The Drosophila gene Bearded encodes a novel small protein and shares 3' UTR sequence motifs with multiple Enhancer of split complex genes. Development. 1997 Oct; 124(20):4039-51.
Leviten MW, Lai EC, Posakony JW. PMID: 9374401.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Gain-of-function alleles of Bearded interfere with alternative cell fate decisions in Drosophila adult sensory organ development. Dev Biol. 1996 Jun 15; 176(2):264-83.
Leviten MW, Posakony JW. PMID: 8660866.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling. Development. 1996 Jun; 122(6):1673-82.
Gho M, Lecourtois M, Géraud G, Posakony JW, Schweisguth F. PMID: 8674407.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway. Dev Biol. 1995 Dec; 172(2):479-94.
Bang AG, Bailey AM, Posakony JW. PMID: 8612965.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev. 1995 Nov 01; 9(21):2609-22.
Bailey AM, Posakony JW. PMID: 7590239.
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PubMed Mentions:
207 Fields:
Translation:
AnimalsCells
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Posterior stripe expression of hunchback is driven from two promoters by a common enhancer element. Development. 1995 Sep; 121(9):3067-77.
Margolis JS, Borowsky ML, Steingrímsson E, Shim CW, Lengyel JA, Posakony JW. PMID: 7555732.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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The sequence similarity of the Drosophila suppressor of hairless protein to the integrase domain has no functional significance in vivo. Dev Biol. 1994 Dec; 166(2):812-4.
Schweisguth F, Nero P, Posakony JW. PMID: 7813798.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete. Genes Dev. 1994 Nov 15; 8(22):2729-42.
Van Doren M, Bailey AM, Esnayra J, Ede K, Posakony JW. PMID: 7958929.
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PubMed Mentions:
71 Fields:
Translation:
AnimalsCells
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Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling. Genes Dev. 1994 Sep 01; 8(17):2058-71.
Singson A, Leviten MW, Bang AG, Hua XH, Posakony JW. PMID: 7958878.
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PubMed Mentions:
48 Fields:
Translation:
AnimalsCells
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Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis. Development. 1994 Jun; 120(6):1433-41.
Schweisguth F, Posakony JW. PMID: 8050354.
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PubMed Mentions:
47 Fields:
Translation:
Animals
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A small region surrounding the distal promoter of the hunchback gene directs maternal expression. Dev Biol. 1994 Jun; 163(2):381-8.
Margolis JS, Borowsky M, Shim CW, Posakony JW. PMID: 8200478.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Nature versus nurture: asymmetric cell divisions in Drosophila bristle development. Cell. 1994 Feb 11; 76(3):415-8.
Posakony JW. PMID: 8313463.
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PubMed Mentions:
38 Fields:
Translation:
Animals
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Dpbx, a new homeobox gene closely related to the human proto-oncogene pbx1 molecular structure and developmental expression. Mech Dev. 1993 May; 41(2-3):155-61.
Flegel WA, Singson AW, Margolis JS, Bang AG, Posakony JW, Murre C. PMID: 8100142; PMCID: PMC7724736.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae. Genes Dev. 1992 Dec; 6(12B):2592-605.
Van Doren M, Powell PA, Pasternak D, Singson A, Posakony JW. PMID: 1340471.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development. Genes Dev. 1992 Sep; 6(9):1752-69.
Bang AG, Posakony JW. PMID: 1516831.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. Cell. 1992 Jun 26; 69(7):1199-212.
Schweisguth F, Posakony JW. PMID: 1617730.
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PubMed Mentions:
90 Fields:
Translation:
AnimalsCells
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The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes. Development. 1991 Sep; 113(1):245-55.
Van Doren M, Ellis HM, Posakony JW. PMID: 1764999.
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PubMed Mentions:
77 Fields:
Translation:
AnimalsCells
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Hairless is required for the development of adult sensory organ precursor cells in Drosophila. Development. 1991 Jan; 111(1):89-104.
Bang AG, Hartenstein V, Posakony JW. PMID: 2015800.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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A dual function of the Notch gene in Drosophila sensillum development. Dev Biol. 1990 Nov; 142(1):13-30.
Hartenstein V, Posakony JW. PMID: 2227090.
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PubMed Mentions:
79 Fields:
Translation:
AnimalsCells
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extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins. Cell. 1990 Apr 06; 61(1):27-38.
Ellis HM, Spann DR, Posakony JW. PMID: 1690604.
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PubMed Mentions:
112 Fields:
Translation:
AnimalsCells
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Sensillum development in the absence of cell division: the sensillum phenotype of the Drosophila mutant string. Dev Biol. 1990 Mar; 138(1):147-58.
Hartenstein V, Posakony JW. PMID: 2106460.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Development of adult sensilla on the wing and notum of Drosophila melanogaster. Development. 1989 Oct; 107(2):389-405.
Hartenstein V, Posakony JW. PMID: 2517255.
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PubMed Mentions:
123 Fields:
Translation:
Animals
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The Drosophila gene knirps-related is a member of the steroid-receptor gene superfamily. Nature. 1988 Dec 01; 336(6198):493-6.
Oro AE, Ong ES, Margolis JS, Posakony JW, McKeown M, Evans RM. PMID: 2848202.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Identification of DNA sequences required for the regulation of Drosophila alcohol dehydrogenase gene expression. Cold Spring Harb Symp Quant Biol. 1985; 50:515-20.
Posakony JW, Fischer JA, Maniatis T. PMID: 3007005.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Comparison of sea urchin and human mtDNA: evolutionary rearrangement. Proc Natl Acad Sci U S A. 1983 Aug; 80(15):4614-8.
Roberts JW, Grula JW, Posakony JW, Hudspeth R, Davidson EH, Britten RJ. PMID: 6308631; PMCID: PMC384094.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the Drosophila germ line. Cell. 1983 Aug; 34(1):59-73.
Goldberg DA, Posakony JW, Maniatis T. PMID: 6309412.
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PubMed Mentions:
85 Fields:
Translation:
AnimalsCells
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Interspersed sequence organization and developmental representation of cloned poly(A) RNAs from sea urchin eggs. J Mol Biol. 1983 Jun 25; 167(2):361-89.
Posakony JW, Flytzanis CN, Britten RJ, Davidson EH. PMID: 6191038.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Transcripts of three mitochondrial genes in the RNA of sea urchin eggs and embryos. Dev Biol. 1983 Jun; 97(2):500-5.
Cabrera CV, Jacobs HT, Posakony JW, Grula JW, Roberts JW, Britten RJ, Davidson EH. PMID: 6189753.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Mitochondrial DNA sequences in the nuclear genome of Strongylocentrotus purpuratus. J Mol Biol. 1983 Apr 25; 165(4):609-32.
Jacobs HT, Posakony JW, Grula JW, Roberts JW, Xin JH, Britten RJ, Davidson EH. PMID: 6687903.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Repetitive sequence transcripts in development. Nature. 1982 Jun 24; 297(5868):633-5.
Davidson EH, Posakony JW. PMID: 6178032.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Organization and expression of multiple actin genes in the sea urchin. Mol Cell Biol. 1981 Jul; 1(7):609-28.
Scheller RH, McAllister LB, Crain WR, Durica DS, Posakony JW, Thomas TL, Britten RJ, Davidson EH. PMID: 9279375; PMCID: PMC369709.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Molecular structure of maternal RNA. Chromosoma. 1981; 84(3):319-35.
Thomas TL, Posakony JW, Anderson DM, Britten RJ, Davidson EH. PMID: 6173173.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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The structure and evolution of the human beta-globin gene family. Cell. 1980 Oct; 21(3):653-68.
Efstratiadis A, Posakony JW, Maniatis T, Lawn RM, O'Connell C, Spritz RA, DeRiel JK, Forget BG, Weissman SM, Slightom JL, Blechl AE, Smithies O, Baralle FE, Shoulders CC, Proudfoot NJ. PMID: 6985477.
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PubMed Mentions:
530 Fields:
Translation:
HumansAnimalsCells
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Evolutionary conservation of repetitive sequence expression in sea urchin egg RNA's. Science. 1980 May 30; 208(4447):1046-8.
Moore GP, Costantini FD, Posakony JW, Davidson EH, Britten RJ. PMID: 6154974.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication. Nature. 1979 Jan 18; 277(5693):192-8.
Crews S, Ojala D, Posakony J, Nishiguchi J, Attardi G. PMID: 551247.
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PubMed Mentions:
57 Fields:
Translation:
HumansCells