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Sergey Kryazhimskiy

Title(s)Assistant Professor, Ecology, Behavior, and Evolution
SchoolVc-academic Affairs
Address9500 Gilman Drive #0116
La Jolla CA 92093
Phone8/8-22--3796
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    Collapse Research 
    Collapse Research Activities and Funding
    Characterizing variation in the local structure of fitness landscapes to assess the predictability of evolution
    NIH/NIGMS R01GM137112Apr 1, 2020 - Jan 31, 2024
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Evolutionary stalling and a limit on the power of natural selection to improve a cellular module. Proc Natl Acad Sci U S A. 2020 Jul 17. Venkataram S, Monasky R, Sikaroodi SH, Kryazhimskiy S, Kacar B. PMID: 32680961.
      View in: PubMed   Mentions:    Fields:    
    2. Chance and necessity in the pleiotropic consequences of adaptation for budding yeast. Nat Ecol Evol. 2020 04; 4(4):601-611. Jerison ER, Nguyen Ba AN, Desai MM, Kryazhimskiy S. PMID: 32152531.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    3. Higher-fitness yeast genotypes are less robust to deleterious mutations. Science. 2019 10 25; 366(6464):490-493. Johnson MS, Martsul A, Kryazhimskiy S, Desai MM. PMID: 31649199.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Detecting genetic interactions using parallel evolution in experimental populations. Philos Trans R Soc Lond B Biol Sci. 2019 07 22; 374(1777):20180237. Fisher KJ, Kryazhimskiy S, Lang GI. PMID: 31154981.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. Modular epistasis and the compensatory evolution of gene deletion mutants. PLoS Genet. 2019 02; 15(2):e1007958. Rojas Echenique JI, Kryazhimskiy S, Nguyen Ba AN, Desai MM. PMID: 30768593.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    6. Genetic variation in adaptability and pleiotropy in budding yeast. Elife. 2017 08 17; 6. Jerison ER, Kryazhimskiy S, Mitchell JK, Bloom JS, Kruglyak L, Desai MM. PMID: 28826486.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    7. Coordinated Evolution of Influenza A Surface Proteins. PLoS Genet. 2015 Aug; 11(8):e1005404. Neverov AD, Kryazhimskiy S, Plotkin JB, Bazykin GA. PMID: 26247472.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    8. Inexpensive multiplexed library preparation for megabase-sized genomes. PLoS One. 2015; 10(5):e0128036. Baym M, Kryazhimskiy S, Lieberman TD, Chung H, Desai MM, Kishony R. PMID: 26000737.
      View in: PubMed   Mentions: 95     Fields:    
    9. Microbial evolution. Global epistasis makes adaptation predictable despite sequence-level stochasticity. Science. 2014 Jun 27; 344(6191):1519-1522. Kryazhimskiy S, Rice DP, Jerison ER, Desai MM. PMID: 24970088.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    10. Refining a key metabolic innovation in Escherichia coli. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2056-7. Kryazhimskiy S, Desai MM. PMID: 24459186.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    11. Loss and recovery of genetic diversity in adapting populations of HIV. PLoS Genet. 2014 Jan; 10(1):e1004000. Pennings PS, Kryazhimskiy S, Wakeley J. PMID: 24465214.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    12. Identifying signatures of selection in genetic time series. Genetics. 2014 Feb; 196(2):509-22. Feder AF, Kryazhimskiy S, Plotkin JB. PMID: 24318534.
      View in: PubMed   Mentions: 26     Fields:    
    13. Multidrug therapy and evolution of antibiotic resistance: when order matters. Appl Environ Microbiol. 2012 Sep; 78(17):6137-42. Perron GG, Kryazhimskiy S, Rice DP, Buckling A. PMID: 22729549.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    14. Population subdivision and adaptation in asexual populations of Saccharomyces cerevisiae. Evolution. 2012 Jun; 66(6):1931-41. Kryazhimskiy S, Rice DP, Desai MM. PMID: 22671557.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    15. The dynamics of social networks among female Asian elephants. BMC Ecol. 2011 Jul 27; 11:17. de Silva S, Ranjeewa AD, Kryazhimskiy S. PMID: 21794147.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    16. Evolution. In evolution, the sum is less than its parts. Science. 2011 Jun 03; 332(6034):1160-1. Kryazhimskiy S, Draghi JA, Plotkin JB. PMID: 21636764.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    17. Prevalence of epistasis in the evolution of influenza A surface proteins. PLoS Genet. 2011 Feb; 7(2):e1001301. Kryazhimskiy S, Dushoff J, Bazykin GA, Plotkin JB. PMID: 21390205.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    18. Young proteins experience more variable selection pressures than old proteins. Genome Res. 2010 Nov; 20(11):1574-81. Vishnoi A, Kryazhimskiy S, Bazykin GA, Hannenhalli S, Plotkin JB. PMID: 20921233.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    19. The dynamics of adaptation on correlated fitness landscapes. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18638-43. Kryazhimskiy S, Tkacik G, Plotkin JB. PMID: 19858497.
      View in: PubMed   Mentions: 43     Fields:    
    20. Isolation and characterization of adenoviruses persistently shed from the gastrointestinal tract of non-human primates. PLoS Pathog. 2009 Jul; 5(7):e1000503. Roy S, Vandenberghe LH, Kryazhimskiy S, Grant R, Calcedo R, Yuan X, Keough M, Sandhu A, Wang Q, Medina-Jaszek CA, Plotkin JB, Wilson JM. PMID: 19578438.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    21. The population genetics of dN/dS. PLoS Genet. 2008 Dec; 4(12):e1000304. Kryazhimskiy S, Plotkin JB. PMID: 19081788.
      View in: PubMed   Mentions: 245     Fields:    
    22. Directionality in the evolution of influenza A haemagglutinin. Proc Biol Sci. 2008 Nov 07; 275(1650):2455-64. Kryazhimskiy S, Bazykin GA, Plotkin JB, Plotkin J, Dushoff J. PMID: 18647721.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    23. Natural selection for nucleotide usage at synonymous and nonsynonymous sites in influenza A virus genes. J Virol. 2008 May; 82(10):4938-45. Kryazhimskiy S, Bazykin GA, Dushoff J. PMID: 18321967.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    24. On state-space reduction in multi-strain pathogen models, with an application to antigenic drift in influenza A. PLoS Comput Biol. 2007 Aug; 3(8):e159. Kryazhimskiy S, Dieckmann U, Levin SA, Dushoff J. PMID: 17708677.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
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