Sergey Kryazhimskiy

Title(s)Associate Professor, Ecology, Behavior, and Evolution
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Characterizing variation in the local structure of fitness landscapes to assess the predictability of evolution
    NIH R01GM137112Apr 1, 2020 - Jan 31, 2024
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Environment-independent distribution of mutational effects emerges from microscopic epistasis. Science. 2024 Oct 04; 386(6717):87-92. Ardell SM, Martsul A, Johnson MS, Kryazhimskiy S. PMID: 39361740.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    2. Environment-independent distribution of mutational effects emerges from microscopic epistasis. bioRxiv. 2024 Jul 09. Ardell S, Martsul A, Johnson MS, Kryazhimskiy S. PMID: 38014325; PMCID: PMC10680819.
      View in: PubMed   Mentions:
    3. A simple rule for predicting function of microbial communities. Cell. 2024 Jun 06; 187(12):2905-2906. Kryazhimskiy S. PMID: 38848675.
      View in: PubMed   Mentions:    Fields:    Translation:CellsPHPublic Health
    4. Upper Bound on the Mutational Burden Imposed by a CRISPR-Cas9 Gene-Drive Element. bioRxiv. 2023 Nov 29. Overton MS, Guy SE, Chen X, Martsul A, Carolino K, Akbari OS, Meyer JR, Kryazhimskiy S. PMID: 38076841; PMCID: PMC10705488.
      View in: PubMed   Mentions:
    5. Evolutionary repeatability of emergent properties of ecological communities. Philos Trans R Soc Lond B Biol Sci. 2023 05 22; 378(1877):20220047. Venkataram S, Kryazhimskiy S. PMID: 37004728; PMCID: PMC10067272.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. What do you most want to understand about how collective features emerge in microbial communities? Cell Syst. 2023 02 15; 14(2):91-97. Segrè D, Mitri S, Shou W, Süel GM, Mizrahi I, Kelly L, Rebolleda-Gómez M, Ratzke C, Ogbunugafor CB, Schwartzman JA, Kryazhimskiy S, Leventhal GE, Kost C, Bell T. PMID: 36796334.
      View in: PubMed   Mentions: 2     Fields:    
    7. Best Practices in Designing, Sequencing, and Identifying Random DNA Barcodes. J Mol Evol. 2023 06; 91(3):263-280. Johnson MS, Venkataram S, Kryazhimskiy S. PMID: 36651964; PMCID: PMC10276077.
      View in: PubMed   Mentions: 12     Fields:    
    8. Mutualism-enhancing mutations dominate early adaptation in a two-species microbial community. Nat Ecol Evol. 2023 01; 7(1):143-154. Venkataram S, Kuo HY, Hom EFY, Kryazhimskiy S. PMID: 36593292.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    9. The population genetics of collateral resistance and sensitivity. Elife. 2021 12 10; 10. Ardell SM, Kryazhimskiy S. PMID: 34889185; PMCID: PMC8765753.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    10. Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster. Nat Commun. 2021 02 12; 12(1):997. Iranmehr A, Stobdan T, Zhou D, Zhao H, Kryazhimskiy S, Bafna V, Haddad GG. PMID: 33579965; PMCID: PMC7881140.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    11. Emergence and propagation of epistasis in metabolic networks. Elife. 2021 02 02; 10. Kryazhimskiy S. PMID: 33527897; PMCID: PMC7924954.
      View in: PubMed   Mentions: 13     Fields:    
    12. Evolutionary stalling and a limit on the power of natural selection to improve a cellular module. Proc Natl Acad Sci U S A. 2020 08 04; 117(31):18582-18590. Venkataram S, Monasky R, Sikaroodi SH, Kryazhimskiy S, Kacar B. PMID: 32680961; PMCID: PMC7414050.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    13. Chance and necessity in the pleiotropic consequences of adaptation for budding yeast. Nat Ecol Evol. 2020 04; 4(4):601-611. Jerison ER, Nguyen Ba AN, Desai MM, Kryazhimskiy S. PMID: 32152531; PMCID: PMC8063891.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    14. Higher-fitness yeast genotypes are less robust to deleterious mutations. Science. 2019 10 25; 366(6464):490-493. Johnson MS, Martsul A, Kryazhimskiy S, Desai MM. PMID: 31649199; PMCID: PMC7204892.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    15. Detecting genetic interactions using parallel evolution in experimental populations. Philos Trans R Soc Lond B Biol Sci. 2019 07 22; 374(1777):20180237. Fisher KJ, Kryazhimskiy S, Lang GI. PMID: 31154981; PMCID: PMC6560277.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    16. Modular epistasis and the compensatory evolution of gene deletion mutants. PLoS Genet. 2019 02; 15(2):e1007958. Rojas Echenique JI, Kryazhimskiy S, Nguyen Ba AN, Desai MM. PMID: 30768593; PMCID: PMC6395002.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    17. Genetic variation in adaptability and pleiotropy in budding yeast. Elife. 2017 08 17; 6. Jerison ER, Kryazhimskiy S, Mitchell JK, Bloom JS, Kruglyak L, Desai MM. PMID: 28826486; PMCID: PMC5580887.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    18. Coordinated Evolution of Influenza A Surface Proteins. PLoS Genet. 2015 Aug; 11(8):e1005404. Neverov AD, Kryazhimskiy S, Plotkin JB, Bazykin GA. PMID: 26247472; PMCID: PMC4527594.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    19. Inexpensive multiplexed library preparation for megabase-sized genomes. PLoS One. 2015; 10(5):e0128036. Baym M, Kryazhimskiy S, Lieberman TD, Chung H, Desai MM, Kishony R. PMID: 26000737; PMCID: PMC4441430.
      View in: PubMed   Mentions: 365     Fields:    
    20. Microbial evolution. Global epistasis makes adaptation predictable despite sequence-level stochasticity. Science. 2014 Jun 27; 344(6191):1519-1522. Kryazhimskiy S, Rice DP, Jerison ER, Desai MM. PMID: 24970088; PMCID: PMC4314286.
      View in: PubMed   Mentions: 228     Fields:    Translation:AnimalsCells
    21. Refining a key metabolic innovation in Escherichia coli. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2056-7. Kryazhimskiy S, Desai MM. PMID: 24459186; PMCID: PMC3926052.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    22. Loss and recovery of genetic diversity in adapting populations of HIV. PLoS Genet. 2014 Jan; 10(1):e1004000. Pennings PS, Kryazhimskiy S, Wakeley J. PMID: 24465214; PMCID: PMC3900388.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    23. Identifying signatures of selection in genetic time series. Genetics. 2014 Feb; 196(2):509-22. Feder AF, Kryazhimskiy S, Plotkin JB. PMID: 24318534; PMCID: PMC3914623.
      View in: PubMed   Mentions: 52     Fields:    
    24. Multidrug therapy and evolution of antibiotic resistance: when order matters. Appl Environ Microbiol. 2012 Sep; 78(17):6137-42. Perron GG, Kryazhimskiy S, Rice DP, Buckling A. PMID: 22729549; PMCID: PMC3416609.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    25. Population subdivision and adaptation in asexual populations of Saccharomyces cerevisiae. Evolution. 2012 Jun; 66(6):1931-41. Kryazhimskiy S, Rice DP, Desai MM. PMID: 22671557.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    26. The dynamics of social networks among female Asian elephants. BMC Ecol. 2011 Jul 27; 11:17. de Silva S, Ranjeewa AD, Kryazhimskiy S. PMID: 21794147; PMCID: PMC3199741.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    27. Evolution. In evolution, the sum is less than its parts. Science. 2011 Jun 03; 332(6034):1160-1. Kryazhimskiy S, Draghi JA, Plotkin JB. PMID: 21636764.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    28. Prevalence of epistasis in the evolution of influenza A surface proteins. PLoS Genet. 2011 Feb; 7(2):e1001301. Kryazhimskiy S, Dushoff J, Bazykin GA, Plotkin JB. PMID: 21390205; PMCID: PMC3040651.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    29. Young proteins experience more variable selection pressures than old proteins. Genome Res. 2010 Nov; 20(11):1574-81. Vishnoi A, Kryazhimskiy S, Bazykin GA, Hannenhalli S, Plotkin JB. PMID: 20921233; PMCID: PMC2963820.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    30. The dynamics of adaptation on correlated fitness landscapes. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18638-43. Kryazhimskiy S, Tkacik G, Plotkin JB. PMID: 19858497; PMCID: PMC2767361.
      View in: PubMed   Mentions: 59     Fields:    
    31. Isolation and characterization of adenoviruses persistently shed from the gastrointestinal tract of non-human primates. PLoS Pathog. 2009 Jul; 5(7):e1000503. Roy S, Vandenberghe LH, Kryazhimskiy S, Grant R, Calcedo R, Yuan X, Keough M, Sandhu A, Wang Q, Medina-Jaszek CA, Plotkin JB, Wilson JM. PMID: 19578438; PMCID: PMC2698151.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    32. The population genetics of dN/dS. PLoS Genet. 2008 Dec; 4(12):e1000304. Kryazhimskiy S, Plotkin JB. PMID: 19081788; PMCID: PMC2596312.
      View in: PubMed   Mentions: 466     Fields:    
    33. Directionality in the evolution of influenza A haemagglutinin. Proc Biol Sci. 2008 Nov 07; 275(1650):2455-64. Kryazhimskiy S, Bazykin GA, Plotkin JB, Plotkin J, Dushoff J. PMID: 18647721; PMCID: PMC2603193.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    34. Natural selection for nucleotide usage at synonymous and nonsynonymous sites in influenza A virus genes. J Virol. 2008 May; 82(10):4938-45. Kryazhimskiy S, Bazykin GA, Dushoff J. PMID: 18321967; PMCID: PMC2346729.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    35. On state-space reduction in multi-strain pathogen models, with an application to antigenic drift in influenza A. PLoS Comput Biol. 2007 Aug; 3(8):e159. Kryazhimskiy S, Dieckmann U, Levin SA, Dushoff J. PMID: 17708677; PMCID: PMC1949840.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
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