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Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster. Nat Commun. 2021 02 12; 12(1):997.
Iranmehr A, Stobdan T, Zhou D, Zhao H, Kryazhimskiy S, Bafna V, Haddad GG. PMID: 33579965.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Genetic interactions regulate hypoxia tolerance conferred by activating Notch in excitatory amino acid transporter 1-positive glial cells in Drosophila melanogaster. G3 (Bethesda). 2021 Feb 09; 11(2).
Zhou D, Stobdan T, Visk D, Xue J, Haddad GG. PMID: 33576765.
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AnimalsCells
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Commentary: Novel Insight into the Genetic Basis of High Altitude Pulmonary Hypertension in Kyrgyz Highlanders. J Lung Health Dis. 2019; 3(2):29-30.
Stobdan T, Haddad GG. PMID: 31304480.
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High fat diet induces sex-specific differential gene expression in Drosophila melanogaster. PLoS One. 2019; 14(3):e0213474.
Stobdan T, Sahoo D, Azad P, Hartley I, Heinrichsen E, Zhou D, Haddad GG. PMID: 30861021.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders. Eur J Hum Genet. 2019 01; 27(1):150-159.
Iranmehr A, Stobdan T, Zhou D, Poulsen O, Strohl KP, Aldashev A, Telenti A, Wong EHM, Kirkness EF, Venter JC, Bafna V, Haddad GG. PMID: 30254217.
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PubMed Mentions:
2 Fields:
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Humans
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Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia. J Mol Med (Berl). 2018 09; 96(9):975-982.
Stobdan T, Zhou D, Williams AT, Cabrales P, Haddad GG. PMID: 30069745.
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PubMed Mentions:
4 Fields:
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AnimalsCells
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The 2018 Lake Louise Acute Mountain Sickness Score. High Alt Med Biol. 2018 03; 19(1):4-6.
Roach RC, Hackett PH, Oelz O, Bärtsch P, Luks AM, MacInnis MJ, Baillie JK, Lake Louise AMS Score Consensus Committee . PMID: 29583031.
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PubMed Mentions:
44 Fields:
Translation:
Humans
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New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude. Mol Biol Evol. 2017 Dec 01; 34(12):3154-3168.
Stobdan T, Akbari A, Azad P, Zhou D, Poulsen O, Appenzeller O, Gonzales GF, Telenti A, Wong EHM, Saini S, Kirkness EF, Venter JC, Bafna V, Haddad GG. PMID: 29029226.
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PubMed Mentions:
7 Fields:
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HumansAnimals
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High-altitude adaptation in humans: from genomics to integrative physiology. J Mol Med (Berl). 2017 Dec; 95(12):1269-1282.
Azad P, Stobdan T, Zhou D, Hartley I, Akbari A, Bafna V, Haddad GG. PMID: 28951950.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10425-30.
Stobdan T, Zhou D, Ao-Ieong E, Ortiz D, Ronen R, Hartley I, Gan Z, McCulloch AD, Bafna V, Cabrales P, Haddad GG. PMID: 26240367.
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20 Fields:
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HumansAnimals
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Prevalence of hypertension at high altitude: cross-sectional survey in Ladakh, Northern India 2007-2011. BMJ Open. 2015 Apr 20; 5(4):e007026.
Norboo T, Stobdan T, Tsering N, Angchuk N, Tsering P, Ahmed I, Chorol T, Kumar Sharma V, Reddy P, Singh SB, Kimura Y, Sakamoto R, Fukutomi E, Ishikawa M, Suwa K, Kosaka Y, Nose M, Yamaguchi T, Tsukihara T, Matsubayashi K, Otsuka K, Okumiya K. PMID: 25897026.
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PubMed Mentions:
13 Fields:
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HumansPHPublic Health
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Interactions between the genes of vasodilatation pathways influence blood pressure and nitric oxide level in hypertension. Am J Hypertens. 2015 Feb; 28(2):239-47.
Kumar R, Kohli S, Mishra A, Garg R, Alam P, Stobdan T, Nejatizadeh A, Gupta M, Tyagi S, Pasha MA. PMID: 25159081.
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PubMed Mentions:
7 Fields:
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Humans
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Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biol. 2014 Feb 20; 15(2):R36.
Udpa N, Ronen R, Zhou D, Liang J, Stobdan T, Appenzeller O, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Claydon VE, Hainsworth R, Gamboa JL, Zibenigus M, Zenebe G, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG. PMID: 24555826.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders. Am J Hum Genet. 2013 Sep 05; 93(3):452-62.
Zhou D, Udpa N, Ronen R, Stobdan T, Liang J, Appenzeller O, Zhao HW, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Gamboa JL, Villafuerte F, Callacondo D, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG. PMID: 23954164.
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PubMed Mentions:
41 Fields:
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HumansAnimalsCells
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Association of GNB3 C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension. Genet Mol Biol. 2011 Oct; 34(4):553-6.
Nejatizadeh A, Kumar R, Stobdan T, Pasha MQ. PMID: 22215956.
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Polymorphisms of renin--angiotensin system genes as a risk factor for high-altitude pulmonary oedema. J Renin Angiotensin Aldosterone Syst. 2011 Jun; 12(2):93-101.
Stobdan T, Ali Z, Khan AP, Nejatizadeh A, Ram R, Thinlas T, Mohammad G, Norboo T, Himashree G, Qadar Pasha M. PMID: 21393362.
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PubMed Mentions:
4 Fields:
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Humans
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Population based study to assess prevalence and risk factors of gastroesophageal reflux disease in a high altitude area. Indian J Gastroenterol. 2011 May; 30(3):135-43.
Kumar S, Sharma S, Norboo T, Dolma D, Norboo A, Stobdan T, Rohatgi S, Munot K, Ahuja V, Saraya A. PMID: 21181325.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):18961-6.
Aggarwal S, Negi S, Jha P, Singh PK, Stobdan T, Pasha MA, Ghosh S, Agrawal A, Indian Genome Variation Consortium , Prasher B, Mukerji M. PMID: 20956315.
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PubMed Mentions:
54 Fields:
Translation:
Humans
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Probable role of beta2-adrenergic receptor gene haplotype in high-altitude pulmonary oedema. Respirology. 2010 May; 15(4):651-8.
Stobdan T, Kumar R, Mohammad G, Thinlas T, Norboo T, Iqbal M, Pasha MA. PMID: 20546540.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Differences in the control of breathing between Himalayan and sea-level residents. J Physiol. 2010 May 01; 588(Pt 9):1591-606.
Slessarev M, Prisman E, Ito S, Watson RR, Jensen D, Preiss D, Greene R, Norboo T, Stobdan T, Diskit D, Norboo A, Kunzang M, Appenzeller O, Duffin J, Fisher JA. PMID: 20194122.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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CYP11B2 gene haplotypes independently and in concurrence with aldosterone and aldosterone to renin ratio increase the risk of hypertension. Clin Biochem. 2010 Jan; 43(1-2):136-41.
Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Gupta M, Tyagi S, Jain SK, Pasha MA. PMID: 19786005.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Adaptation and mal-adaptation to ambient hypoxia; Andean, Ethiopian and Himalayan patterns. PLoS One. 2008 Jun 04; 3(6):e2342.
Xing G, Qualls C, Huicho L, Rivera-Ch M, River-Ch M, Stobdan T, Slessarev M, Prisman E, Ito S, Ito S, Wu H, Norboo A, Dolma D, Kunzang M, Norboo T, Gamboa JL, Claydon VE, Fisher J, Zenebe G, Gebremedhin A, Hainsworth R, Verma A, Appenzeller O. PMID: 18523639.
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PubMed Mentions:
27 Fields:
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Significance of angiotensinogen gene haplotypes and genotypes combinations in hypertension. J Hypertens. 2008 Jun; 26(6):1094-101.
Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Gupta M, Javed S, Pasha MQ. PMID: 18475146.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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The genetic aspects of pre-eclampsia: achievements and limitations. Biochem Genet. 2008 Aug; 46(7-8):451-79.
Nejatizadeh A, Stobdan T, Malhotra N, Pasha MA. PMID: 18437552.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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Genetic landscape of the people of India: a canvas for disease gene exploration. J Genet. 2008 Apr; 87(1):3-20.
Indian Genome Variation Consortium . PMID: 18560169.
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PubMed Mentions:
116 Fields:
Translation:
HumansCells
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Endothelial nitric oxide synthase gene haplotypes and circulating nitric oxide levels significantly associate with risk of essential hypertension. Free Radic Biol Med. 2008 Jun 01; 44(11):1912-8.
Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Sikdar S, Gupta M, Javed S, Pasha MA. PMID: 18325347.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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High altitude adaptation: genetic perspectives. High Alt Med Biol. 2008; 9(2):140-7.
Stobdan T, Karar J, Pasha MA. PMID: 18578645.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Life on the Qinghai-Tibetan Plateau. Proceedings of the 6th World Congress on Mountain Medicine and High Altitude Physiology. Genomics of high altitude adaptation and maladaptation. 2007; 374-386.
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Susceptibility to high altitude pulmonary oedema: role of ACE and ET-1 polymorphisms. Thorax. 2006 Nov; 61(11):1011-2.
Charu R, Stobdan T, Ram RB, Khan AP, Qadar Pasha MA, Norboo T, Afrin F. PMID: 17071838.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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Predominance of interaction among wild-type alleles of CYP11B2 in Himalayan natives associates with high-altitude adaptation. Biochem Biophys Res Commun. 2006 Sep 22; 348(2):735-40.
Rajput C, Arif E, Vibhuti A, Stobdan T, Khan AP, Norboo T, Afrin F, Qadar Pasha MA. PMID: 16893516.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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The Indian Genome Variation database (IGVdb): a project overview. Hum Genet. 2005 Oct; 118(1):1-11.
Indian Genome Variation Consortium . PMID: 16133172.
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PubMed Mentions:
43 Fields:
Translation:
Humans